<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0E2</accession>
    <name>A0A0D2U0E2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0E2"/>
    <dbReference type="FunCoup" id="A0A0D2U0E2">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0E2"/>
    <dbReference type="eggNOG" id="KOG4342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0E2"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0E2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10813">
        <property type="entry name" value="GH38N_AMII_Man2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="601"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125011" checksum="3E0E6914BCA1F7A3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1L2</accession>
    <name>A0A0D2U1L2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365499.2">
        <property type="nucleotide sequence ID" value="XM_004365442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1L2"/>
    <dbReference type="STRING" id="595528.A0A0D2U1L2"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1L2"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1L2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="173"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="45416" checksum="519E08B9D7CCA88C" modified="2015-04-29" version="1">MTRASTKRTAATASASDAAVDPAAAATTAAVAAPITKKTRVSKASASAAGGEDEQEAPTARRSSRAKTTTTNTATTTTTVTTTVTVASDTASAMEVDTPDDASVKGKGKKAKAPAKKAEKDDADDDAAETDAATEKTVVANVKFSAEALKTLTYTTSRAAPNGKPINFKIACWNVNGLKNAIKEGCLQYLEYEKPDVLCIQETKCGEGEIPADSAVPGYYGYWYSAQKRGYAGTGMYSKTQPIRVSFGLNVPEHDTEGRVITAEFADFYLVTAYVPNSGQKLETLPYRQTWDVAFRTYLLSLDAKKPVVLCGDLNVAHNEIDLKNPKTNKRSAGFTPQEREGFTTILGTEFVDSFRVLYPEESAYSFWSYRHNSRALNVGWRLDYFVVSQRFMQSVADSQIRSQVYGSDHCPIVLHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3A2</accession>
    <name>A0A0D2U3A2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gh regulated tbc protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365959.2">
        <property type="nucleotide sequence ID" value="XM_004365902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3A2"/>
    <dbReference type="STRING" id="595528.A0A0D2U3A2"/>
    <dbReference type="eggNOG" id="KOG2221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3A2"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3A2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="70"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="911" mass="99734" checksum="67C4BD33EDC436D3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U679</accession>
    <name>A0A0D2U679_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364779.2">
        <property type="nucleotide sequence ID" value="XM_004364722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U679"/>
    <dbReference type="FunCoup" id="A0A0D2U679">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U679"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U679"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U679"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="509" mass="57403" checksum="1FDB50E9958B33B8" modified="2015-04-29" version="1">MSGLFKSFGTKKDKKDDKKEDKKDDKTKTLKKDGSSSSKPETKEEDLDKPHGKLVVNVSSGRGFAPTSANVVCVVSFERNQTLSKTSDGATPKWDQSITFDVTDKGRDLTIECYSRGASGNELIGSVRIQPSYGDQASMTDQWYRLRNKDNTADTAAELHVVHTYKHTEATRSLTINDFDLLKVIGKGSFGKVMQVRKKDTNRIYAMKILKKSHLVERDEVGHTKSERIILAKNCSPFLVGLKFSFQTPEKIYLVLDYVNGGELFFHLQNEGKFSEQRSKFYTAQLLSALESLHAINVIYRDLKPENILVDFDGFIALTDFGLCKEEIKHDEKTNTFCGTPEYMAPEVLQQKGYGPSVDWWTLGILLYEMLTGLPPFYDENTNQMYHKILFGDLVFTDEISPKARSLIAGLLDRDPAKRLGAGPNGAKEIKQHAFFEDMNFADLEAKRVPVPWKPSLENQFDTSNFDPEFTEMQPQDSVVPDSHLSATVQNQFKGFTYVDHSEALQGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7A4</accession>
    <name>A0A0D2U7A4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SNF2 family DNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_002220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348970.2">
        <property type="nucleotide sequence ID" value="XM_004348920.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U7A4"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7A4"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7A4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="568"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1094"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1573"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1780"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1823"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1930"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2134"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2258"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1299"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1378"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1830"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1862"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1930"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2134"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2270"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="2282"/>
            <end position="2292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE91016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2352" mass="255396" checksum="23198037FEB90B1B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8D7</accession>
    <name>A0A0D2U8D7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 8"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8D7"/>
    <dbReference type="STRING" id="595528.A0A0D2U8D7"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8D7"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8D7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="10">
        <location>
            <begin position="179"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="52299" checksum="2796257F0C72860C" modified="2015-04-29" version="1">MDTSGSPFSSSSGDNAPSAATPGTAVPFPLSTGARLQARWQDGTWHRAEIIETRPTLGDYYVHYIDFNRRLDEWVSPDRLDFATVESAEAAASTPNELAGTGLERSAIIASSAAIAMTGGSSAMVTVSAAGTTIPAIAPERKMTRNMRKRFNEENHIPKALEEMDPTTRALEREYEEVTKVKFINKIHIGSYEVDTWYFSPYPDDYGKVDKLYICEWCLKYMKYARTLAKHQSECKCREPPGKQIYQFKTNSVFELDGKVSKIYCQNLCLLAKLFLDHKTLYFDVEPFLFYILTEDDEEGRHVVGYFSKASLEKISPEGNNVACILTLPPFQRKGYGKLLIEFSYELSKMEKKVGSPEKPLSDLGNLGYRSYWAFILLSKLKEHKGMLSIKELSRLTSITHDDIITTLQSLGLVRYWKGQHIISVSLRVIEEHFKSPHLKPPPLRVEPSCFRWTPPELSKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8X7</accession>
    <name>A0A0D2U8X7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349399.1">
        <property type="nucleotide sequence ID" value="XM_004349349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8X7"/>
    <dbReference type="STRING" id="595528.A0A0D2U8X7"/>
    <dbReference type="eggNOG" id="ENOG502QQII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8X7"/>
    <dbReference type="OMA" id="IWPATFC"/>
    <dbReference type="OrthoDB" id="10069455at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8X7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="108"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37329" checksum="8933467AB913BC5C" modified="2015-04-29" version="1">MATPHQASFCCSQTLPNEQLDVFNAMCLVCSLASASASVFSLLREDKFYLSRLRAAEERRFQPTIVAWLFLSDFMACIGVIVRSILSLSRTAGASEDDPQGRPPYPELCISVDVYITFFFIVTFFWTFSFALEQWLYTAGIKHRMWWFHVISWLAALALTAIGNGIVDASSGFACESSETMLRARYLAIFIPMLFVLLANPTLFCLAYVARRRNARAEGEVTAQTRDRARQVLLQMAEISFVFIVCWMPSIVNGVMEYADVTTTGNSLFALWVIQGITNPSQGLLNMFVYSRVPSSHVGVVYNRYSTDALEEHSRLVPAQSKPRNTTPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9F2</accession>
    <name>A0A0D2U9F2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349544.1">
        <property type="nucleotide sequence ID" value="XM_004349494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9F2"/>
    <dbReference type="InParanoid" id="A0A0D2U9F2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="151" mass="17381" checksum="3F816BA2F47CCB0F" modified="2015-04-29" version="1">MEYQEQQPPPPQYVSEVNLAALLPEAVVDLPTFLKLRMDPSDNTFLLETSYELLSKAPERLSLFRQGLATGDYIALKHLAHREKGSASTLGFNRLANAMLRFEYASYLVIYQFIQPDAQQFSTLYYTIEREYSVLRDYLQKLFASQAHPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBD0</accession>
    <name>A0A0D2UBD0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364179.2">
        <property type="nucleotide sequence ID" value="XM_004364122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBD0"/>
    <dbReference type="InParanoid" id="A0A0D2UBD0"/>
    <dbReference type="OrthoDB" id="161999at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBD0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17057">
        <property type="entry name" value="Ubl_TMUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040352">
        <property type="entry name" value="TMUB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF5">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19133" checksum="232446B846F4462E" modified="2015-04-29" version="1">MMDAANPAQSGSDIILLRLKVGEQDRSALATRDMTLAELCATHFRDALAQGNGVKFIHSGRLLQPDTATLEALGLQPGAVIHCQVYPLQPGQQANNASENSQPRSATGPSEAEWLASAGLGQSRQSSSPELDRFLTPLVWIIVAALWAIYYVYGRYAFDNVGFALLVMITGGALMATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDH7</accession>
    <name>A0A0D2UDH7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CCR4-NOT transcription complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003929</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363657.2">
        <property type="nucleotide sequence ID" value="XM_004363600.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDH7"/>
    <dbReference type="FunCoup" id="A0A0D2UDH7">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDH7"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDH7"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDH7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="568"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="463"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="697" mass="75093" checksum="0F33CC27A5DA70CA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF07</accession>
    <name>A0A0D2UF07_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348258.2">
        <property type="nucleotide sequence ID" value="XM_004348208.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF07"/>
    <dbReference type="InParanoid" id="A0A0D2UF07"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958">
        <property type="entry name" value="CONDITIONAL LOSS-OF-GROWTH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="968" mass="104192" checksum="01FEA30B29FA5B11" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGJ6</accession>
    <name>A0A0D2UGJ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SNF2 superfamily RAD5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004876</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347627.1">
        <property type="nucleotide sequence ID" value="XM_004347577.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UGJ6">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGJ6"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGJ6"/>
    <dbReference type="OMA" id="HTHRFED"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGJ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="596"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="1043"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1181"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="971"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE94196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1372" mass="146070" checksum="40EC160BC09A8243" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHG7</accession>
    <name>A0A0D2UHG7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHG7"/>
    <dbReference type="FunCoup" id="A0A0D2UHG7">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHG7"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHG7"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25403" checksum="02F8D73680C2D43E" modified="2015-04-29" version="1">MGGVFGKASSASTSSNGAKQQSRITPHDRAVLDLKKQRDNLKIYIHKIEAVLKREHELARTAVREGNKKKALLLLKRKRFQETLIERAEGQIQNVEELTASIEFAVVEQQVLAGIKAGTETLTELNNQMKLEDVERLMDDTQEAIAYQNEISEMLGTSLSEVDEAAVLAELEELEVASSAIQTAPDVPTHALPADSAASDAVQEAEEAGQPAGEMDGVLNSKTGDFALKGFLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ76</accession>
    <name>A0A0D2UJ76_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ76"/>
    <dbReference type="InParanoid" id="A0A0D2UJ76"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="508" mass="55199" checksum="394C18D5BB44548B" modified="2015-04-29" version="1">MAARAKQRLQYTHIVQRRLDTLSGMEDATVDVRVKVGARDAHFLFCSNEVDDGIVKRQRAANSDDDASPRMVDGDIEGRFENAVAKAHVRNVTVVQPRLLFERGQVARAAIVANIDVLGGRGPRGVSLGIRNVIACKLGLVAARGALAVAHVQAAQTGAQVHKEVERPAVDAQGQLTKVVHFRKVGRIDFGMQAKAARVSLRYLVVNPGGGPGARQERSGHAARGRLAVGSWVVRQRAGGGKPGRQRARIGAQLAAASRLCTIDAGGLANDASALFHTLPSAQNGQSGGNVGRDDIEVLEKAGQELRELHPNLPIAKRRLRGRAGGEIVRHTAEEASQLGRPRFGVRLGGAVLGARSWVGNRTHRIKHEPKGDELNPDQAPVCNNDGMQHIGDDVVEVLLAREAVLEEDFVDTPPRERQLEDAERKSSQEQAWDGFPCARVQDASLQRGPHNDELQNHHDAVQTETSEQVRLQHVKPVAFAVARRGVRINDSEARNPMMHFRLISKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJZ9</accession>
    <name>A0A0D2UJZ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345476.1">
        <property type="nucleotide sequence ID" value="XM_004345426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJZ9"/>
    <dbReference type="STRING" id="595528.A0A0D2UJZ9"/>
    <dbReference type="eggNOG" id="KOG1621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJZ9"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="48939" checksum="6313D55002E4C6F5" modified="2015-04-29" version="1">MASTGHAAAGPPGTVGPSQLTPAADNTVGASQTSLDAFDDRLAQLDNAKMAAILSRPTVKAVRSEPVLRAVQCSSTTSLDMVGKSLSNSDLSSCDEDDLREPTIGMRNGLSRAQSDRARRAWRKVISLAKILIHYSTRYSHQVAGHKDAFLHPQQGILCKRTTTLERDALMLLMSDCMREFVPRFDREITYGGETYVQMEDLLASFVRPSLMDIKMGKRTFLESEVTKLDKRSDLLEKMREIDPNEPTPEEIDSGGITKLRYMQFREQQSSSASLGFRVEGIKLADRKADTNFKTVKTEQDVADVFRHYLSLLPERHRSEFTARLELIRQRIESSEFFKMHEVVGSSLLFVYDHSGKVGLWLIDFAKTNRSRKPLTHRQPWNLGNQEDGYLCGLDTLIRVWREVDSSSHISASAAAPTTSIPPPSAATVAPVPATANGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNV5</accession>
    <name>A0A0D2UNV5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NCBP 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344551.1">
        <property type="nucleotide sequence ID" value="XM_004344501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNV5"/>
    <dbReference type="STRING" id="595528.A0A0D2UNV5"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNV5"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNV5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000538">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="359" mass="38217" checksum="1690D7C72E2B381C" modified="2015-04-29" version="1">MASVIPIDFTESQYRDQRFKGEKEEQSRKLANSTTLYVGNLSFTTTEPQMVELFSKCGPVRRVVMGLDRIKRTPCGFAFVEYYTRRDAEDCMKYVTGTRLDDRPIRTDWDVGFEEGRQFGRGMSGGQVRDEFRDDFDEGRGGFGKGTPTGGTGGVGVRPGGPFNAGYGGSGRHHHHHGGGGQGHQGYNGSQGSQGQGHGYNGSRGGYGGGGQQQRNNRNNHQSNNYQSNNSNAGGRYHHSSSSSSGWGNNYQQAPLYAQQPPPALGSAFAIAEAAAAAAAAASAKRPHEDANSPSDSANTVSTTAAADDSSEHASKRQRMGDDGESSATSQPIFDQATAAAAASADTGDDVEDMVQYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQD5</accession>
    <name>A0A0D2UQD5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343528.2">
        <property type="nucleotide sequence ID" value="XM_004343478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQD5"/>
    <dbReference type="eggNOG" id="KOG3241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQD5"/>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQD5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="378" mass="41187" checksum="DC5B1EB9456AEEBF" modified="2015-04-29" version="1">MSTSRSGNTKKQGQKYQNAFAYQHNKNSKLTKRIMALPVDGLCFRCKDIVDWRKRFRKYKPLTQPKVCTSCSKRTVTKAYHVICDGCAEIKKVCAKCLERTDIAPKENYTPTELFHEEQKRDNELRALRERDRRKVLRLAEAEAEDDSDAEGSDDDEDGAPAGKSEPAVHRSERVIGSMSRRPLAESAKPSNPAGASDDDDDDEDDEADEEDFDDEDFDDDDDDEQDFDEEDDEEDDNLPAKPATGKASAGRPSATSAGKGKSKSSNSALDALDQEIDELLALDGMELDDDDDDEELTAAEIAHARAVHRRLKEREALSGGSATRKPAASATFATAASTAPAVPAASTASAVRKPAGGRVVKTASGVKMRIGPTLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQH9</accession>
    <name>A0A0D2UQH9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007698</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343572.1">
        <property type="nucleotide sequence ID" value="XM_004343522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQH9"/>
    <dbReference type="FunCoup" id="A0A0D2UQH9">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQH9"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQH9"/>
    <dbReference type="OMA" id="AHSDVHR"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="13">
        <location>
            <begin position="77"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="548" mass="58119" checksum="4BA8DE6E9442E4C1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USL4</accession>
    <name>A0A0D2USL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USL4"/>
    <dbReference type="FunCoup" id="A0A0D2USL4">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2USL4"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USL4"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265709" description="40S ribosomal protein S26" evidence="6">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="176" mass="19750" checksum="A82CA29584B445F4" modified="2015-04-29" version="1">MLQWFFCIDFFDLYFAFRFCWRQKSFWIALSFPAVFMTQKRRNNGRAKHGRGHVKPIRCTNCGRSVPKDKAIKRFVVRNIIESAAVRDITDASVFEVYALPKMYLKQQYCVSCAIHSKVVRNRSAVDRRNRDPPPRIRRPAEGAKKPTGPRTPAAGAAAPAAAAAPAAATPAPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK88</accession>
    <name>A0A0D2VK88_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK88"/>
    <dbReference type="InParanoid" id="A0A0D2VK88"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="215" mass="24059" checksum="A11EF597E9BBEDDB" modified="2015-04-29" version="1">MSEPQQTPLQPIPIERPKRTLTEEQKKNLAAAREIARKKREAEFAPIDVDSEDDVEPPPVRHRTPRQKPQKPSLYDSVSESASDAATSAASFLTKAGMLLFAGFVLKKVLGAVAQSPSALAPVKEVVNVTPLVVDHTTETVKSAVGPVMFTNVKSQEIKAKAPLAYKPDANIDAMRFNCLKWRTAYLMRFSMYPVYRLHCLQELYEHLHLKNTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMK7</accession>
    <name>A0A0D2VMK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349294.1">
        <property type="nucleotide sequence ID" value="XM_004349244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMK7"/>
    <dbReference type="InParanoid" id="A0A0D2VMK7"/>
    <dbReference type="OrthoDB" id="745018at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="802" mass="85625" checksum="0BD36D2E7B50D6FB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMQ3</accession>
    <name>A0A0D2VMQ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMQ3"/>
    <dbReference type="InParanoid" id="A0A0D2VMQ3"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41193" checksum="F917BBE10EDC983E" modified="2015-04-29" version="1">MSESQRELHDIVKNANGWIWWDGKKIGNDGAQAVAEALKVNTTVTHLDVRENQIGDVGARAIAETLKVNKTVVEVALSWNQISDAGARAIAETFKVNTNLRWLILYHNQIGDAGAQAIAEALKVNTNLILLYLSVNRIGDIGALALAEALKVNKTLTDLTLENNCIGQVGIQALGEARKVNGILTKLDIQDQINPLAFSLLPRLATSEDWQSVFHLLTGRHEKENQPALLPALPAEVAELVMHEAEYLQGVQHIHQAWARNNQIAFLKLTMPRSSNGNSIRVKAIQVLREQSEAKSGRFDLIVRDELGAVRYKWAAEAPVVGSNIQLVTISPTDHPVIRQMREGWEVEVELGQYYSFVRLASLSVGYIERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP55</accession>
    <name>A0A0D2VP55_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003193</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364032.2">
        <property type="nucleotide sequence ID" value="XM_004363975.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP55"/>
    <dbReference type="STRING" id="595528.A0A0D2VP55"/>
    <dbReference type="eggNOG" id="ENOG502QTMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP55"/>
    <dbReference type="OrthoDB" id="10038011at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="528"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="667" mass="70673" checksum="7A6FA314DBFA38D8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQL3</accession>
    <name>A0A0D2VQL3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363568.1">
        <property type="nucleotide sequence ID" value="XM_004363511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQL3"/>
    <dbReference type="InParanoid" id="A0A0D2VQL3"/>
    <dbReference type="OrthoDB" id="10592505at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="275" mass="31369" checksum="B5D35940E03AC001" modified="2015-04-29" version="1">MPSQGQLLHKAFEQANLPLTITATAREFAWGARDSTSFLMDIRNTKGLGKNEFKQKFVAYLGDGTDLQVTNVDPALHQLVLTVQEPVREIVTVRREWMMMERRYIEHTDRQWTTGNLHCHLVGVDEGHLFFCELPNVVSTVHQAHQLLRPKQLVNKPKTAFKRQGEWFLVPVPVSECAKIQEAATPVAPAPFEPWGRAVPNVQTHYRNTALGVHIGRGPGRGHVADEIVVYGGREFARGKLQHPDHVPRHLKDWHEVLRNQEKTSNVLKHTNWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQW7</accession>
    <name>A0A0D2VQW7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347811.2">
        <property type="nucleotide sequence ID" value="XM_004347761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQW7"/>
    <dbReference type="STRING" id="595528.A0A0D2VQW7"/>
    <dbReference type="eggNOG" id="KOG2236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQW7"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="616" mass="64531" checksum="E274F271F11D3DC4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRW3</accession>
    <name>A0A0D2VRW3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="4">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_004431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="4"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348259.1">
        <property type="nucleotide sequence ID" value="XM_004348209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRW3"/>
    <dbReference type="FunCoup" id="A0A0D2VRW3">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRW3"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRW3"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRW3"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="267"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="664" mass="70786" checksum="4F49E1CAB867EFD1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS73</accession>
    <name>A0A0D2VS73_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyridoxal phosphate phosphatase PHOSPHO2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347362.1">
        <property type="nucleotide sequence ID" value="XM_004347312.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS73"/>
    <dbReference type="STRING" id="595528.A0A0D2VS73"/>
    <dbReference type="eggNOG" id="KOG3120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS73"/>
    <dbReference type="OMA" id="FHSHECQ"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35711" checksum="3F341BB95E0217F5" modified="2015-04-29" version="1">MSAPNSAAGNSSTRETFLSVDLAKAVQHLADRGTTDRVLCVFDFDWTIVDTNSDEYVIEQLAPDLHSRFEETRLSTPLFRQSWLAYMNYLMGQLHELGFSAADISRSLKATPLSLEMQEVLRTLTASGKVDVVVLSDANEFFIRETLQHYNLLEHVSLIISNPFLHDPRFTILPFSPTRHSDHICTLCNDNMCKGTVLDYILDKTEYHRVVYIGDGGNDFCPSTRLCSSDVVMARDGFHLVRLLRKYIAAERQKAVSTHGAHLHRRRRAKHTSHPEGLRGQRLNADKFDVDAEVQVWCSHADLLALFRSLLLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSR5</accession>
    <name>A0A0D2VSR5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ECSIT N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347610.1">
        <property type="nucleotide sequence ID" value="XM_004347560.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSR5"/>
    <dbReference type="STRING" id="595528.A0A0D2VSR5"/>
    <dbReference type="eggNOG" id="KOG3941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSR5"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSR5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECSIT N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="459" mass="49655" checksum="3525AFF706740BCF" modified="2015-04-29" version="1">MALSGIGRGIAAGQAWPSNLLALTRLTPLPTHSVTAIAAAAATAACFSPMVAHGRRGGASLARGEAAGAAETAALNAVAAAASASKQGNPLQASMNSTSMPLSEHGALASASLSSSSSSPSSSSSAPAISAGHLMRHMGAASNLAQIEAVVDAFRELKSVRGSVEFIEAAITRLDALDLDIPKRTYDKLLDVFPKNHTVTRSWLDVMWPRENAAVETALKLLQRMEDASICPDLETFKPVFYAFGKKSVPVRKCESMYYWMTLFGMNPKSKSYQIKALPEDLTLVTQLALNRLVGVSDAQIHQHGVFQRDGNGAVDVGHVDHVPPVVSYERPEALAQLDGSKSLVVTGPHLNWFRRTFQPYYTISPESEPSQILGYCMTTRHDDTTLMAWIRAVPKFATANIRFNFSPLAKTASTLHGQRFRRQLYGRVSRLPTIEEQHWQETPEAQKLIAASKNDFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU10</accession>
    <name>A0A0D2VU10_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346091.2">
        <property type="nucleotide sequence ID" value="XM_004346041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU10"/>
    <dbReference type="STRING" id="595528.A0A0D2VU10"/>
    <dbReference type="eggNOG" id="ENOG502QQKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU10"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253882" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="832" mass="89317" checksum="9A87E74E7D8BDD73" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU97</accession>
    <name>A0A0D2VU97_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tnf receptor-associated factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346151.2">
        <property type="nucleotide sequence ID" value="XM_004346101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU97"/>
    <dbReference type="STRING" id="595528.A0A0D2VU97"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU97"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU97"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16644">
        <property type="entry name" value="mRING-HC-C3HC3D_TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056454">
        <property type="entry name" value="Beta-prop_IP5PC_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF6">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23754">
        <property type="entry name" value="Beta-prop_IP5PC_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="555"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="716"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="756"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="6">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="830" mass="89576" checksum="E99B98ADB34D7912" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV05</accession>
    <name>A0A0D2VV05_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VV05"/>
    <dbReference type="eggNOG" id="ENOG502SAGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV05"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV05"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="13">
        <location>
            <begin position="1234"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1281" mass="142150" checksum="1C17E767783FF4EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWT0</accession>
    <name>A0A0D2VWT0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345165.2">
        <property type="nucleotide sequence ID" value="XM_004345115.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VWT0"/>
    <dbReference type="eggNOG" id="ENOG502QT0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWT0"/>
    <dbReference type="OrthoDB" id="17798at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2032"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2263" mass="250416" checksum="BDDFD92AFCF42C6C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY24</accession>
    <name>A0A0D2VY24_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY24"/>
    <dbReference type="InParanoid" id="A0A0D2VY24"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY24"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53138" checksum="40442C084A1FB2D7" modified="2015-04-29" version="1">MLDQILRDLTHNVKFASWELSLNHELIGDDEAKAIAEALKVNTTVTTLKMDENQIGAVGAHAIADALKVNTTLTWLNLQENQIGNAGAQAIAATLKVNTTLTELSLGQNQIGQVGAQAIAEGLRVNTTLTSLDLGESPIGVAGVNAIAEALKVNTTLKKFGLWRSQIDDAGAQAIAATLKVNKTLTTLFLEENQFSDAGAQAIAEALKVNTALTVLGLNVNRIGSRGAQALAEALKVNKRLSVLILSENLIGDAGAQAIAEALKVNTTLTALHLSYNCISDVAVQAIEEVRRANSTTSVYMLHQINPLSFSLPPRAAMATDLELVFSVLISGPELNHPSASLPMLPVELAERIMDEAHYWQGVQHTKRDYFEEDNLEVSVPLSTSGTSIRVKAIQVLRDWQTQPFVVGDVAFDVVVRDAQGAVQSEAAVRPTFVDTVQLVTIWPANLPIIRQMREGWQVQVRPSSSLSHRVRYESLYVGYEGILATNLQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYG9</accession>
    <name>A0A0D2VYG9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_010049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYG9"/>
    <dbReference type="STRING" id="595528.A0A0D2VYG9"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYG9"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269619" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="431"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="643" mass="68383" checksum="5C7A344DA4F8DF82" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYM5</accession>
    <name>A0A0D2VYM5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343823.2">
        <property type="nucleotide sequence ID" value="XM_004343773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYM5"/>
    <dbReference type="eggNOG" id="KOG4543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYM5"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="4">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="162" mass="17486" checksum="95BE0DF9205CD413" modified="2015-04-29" version="1">MMAGQSDASSSASAAPPSSSTLEQQPQQQQQRGERLSTQCSLCAHPVPYDYTGKTPPFAPRVVFLEDVFAIRDPFAVAAQTASLAAASLPKRCLAMGARCAECNRIVCMQATCSLFYQKRFCALCAKQWANCFPSQLKPDLERLREGHGSSSSTSTRSQAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZU0</accession>
    <name>A0A0D2VZU0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZU0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254643" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1590" mass="172494" checksum="682CF717A8853BF4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W059</accession>
    <name>A0A0D2W059_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343246.1">
        <property type="nucleotide sequence ID" value="XM_004343196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W059"/>
    <dbReference type="STRING" id="595528.A0A0D2W059"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W059"/>
    <dbReference type="OMA" id="SNTIAFW"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W059"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="392" mass="41566" checksum="2128B22C9F186312" modified="2015-04-29" version="1">MGDHTESEPLLSNPDYHATNAVRYHRTVTFTGDATAHHHQSHSHVHGHTHSHSSSGNGNGSGHAAAGQADLNRGLSINNHSQDAPLDAARQHATYKANPGRQAGPRASQARGLEAFDSDDDDDDDGNTNSPREYHRKRRVVAPFQPSLTADLLAETLGTFVMVLFALGSVAHLVVGTSNPLAVHIGNGLGVCIGVMVSHGGHLNASVTLALAVFKGFPWRKVPLFILAQFVGSFLAAALVYAIYYDGIEEFDGGSRHVTGTKATAGIFATYLAPGVSIGEGFADQILATALLLMGLFSITDKQNPSVGKHGLPPSAGVLVTAIGISFGFNCGYPLNPMRDFGPRLFTYMAGWGGEVFTAGDSWSWVPLVAPPLGGLLGSAMYQLMIERPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0J6</accession>
    <name>A0A0D2W0J6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342909.1">
        <property type="nucleotide sequence ID" value="XM_004342860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0J6"/>
    <dbReference type="STRING" id="595528.A0A0D2W0J6"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0J6"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0J6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="212" mass="24319" checksum="06598BB5FC5AC37B" modified="2015-04-29" version="1">MSIIYSLVSCGSTILAEYTDKTGNFTTITQTILDKIPPQNAKMTYVYDRHLFHYIAEDGFVYLCMADEAFGRRVPFAFLLDVKSRFESTYKARARTAFAYGLNRELAPILKQQMEYYSQNPNSDRINQVRNEIAQVKDVMVQNIEKVLERGERIDLLVDKADNLNQAAFQFKKSSTKLKRNFCWQNARLTIIIVIVVAVILTLIILLATGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1N0</accession>
    <name>A0A0D2W1N0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342483.1">
        <property type="nucleotide sequence ID" value="XM_004342434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1N0"/>
    <dbReference type="FunCoup" id="A0A0D2W1N0">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W1N0"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1N0"/>
    <dbReference type="OMA" id="PTWPIHE"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1N0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="50"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="45712" checksum="480522DE0231D9E9" modified="2015-04-29" version="1">MLSQQSLRITTKIAASPARFASLWAGVPEGPADPILGLTEAWRKDPSPAKINVGVGAYRDANGKAFVLPSVRKAEAIIAGKNLDKEYASIEGHADFRSAALKFALGKDLFKDVHAATVQSISGTGALRLGGEFLRRFHRKPEVALPDRTWPTHDKILNAAGVSTSSYRYYDASTISLNFKAMVEDLTQRAPGSAVLLHACAHNPTGIDPTQAQWEELAQVFKTQKLLPFFDMAYQGFASGDPSRDAFAVRHFVQQGLHPILTQSFAKNMGLYGERVGAFTVLCETAAEASAVLSQLKLIIRPMYSSPPINGARIATHILNTPELTAEWEGELKLMSGRIIEMRETLVKELKAAGSTKNWDFITKQIGMFCYSGMTAKHVQELREKHSIYMTSDGRISMVGLTHANVGALARAMHAVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGT9</accession>
    <name>A0A0D2WGT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGT9"/>
    <dbReference type="InParanoid" id="A0A0D2WGT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="162" mass="17506" checksum="579661364D7E986F" modified="2015-04-29" version="1">MRLGGRDGRRGQARLDAGRRSFLCSQDGGIDNRHVEGIHARFLEADGGGAVLDEAKIKQLLSVAPALVDIEVEAADKPVDRLLAHKAAAQREEQPRAIADFEATGAGVNQGGENAGNVVGHQGQTRHGIRPVVAVRDHRGGSRSRADWGTGRSRDGRWRCYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHU9</accession>
    <name>A0A0D2WHU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase ago61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHU9"/>
    <dbReference type="STRING" id="595528.A0A0D2WHU9"/>
    <dbReference type="InParanoid" id="A0A0D2WHU9"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254387" evidence="9">
        <location>
            <begin position="17"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="422"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="779" mass="86506" checksum="8F0692BF9BD2EDB5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHV3</accession>
    <name>A0A0D2WHV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364938.1">
        <property type="nucleotide sequence ID" value="XM_004364881.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHV3"/>
    <dbReference type="FunCoup" id="A0A0D2WHV3">
        <property type="interactions" value="685"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHV3"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHV3"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="94" mass="10263" checksum="AB92B38E0781B4AB" modified="2015-04-29" version="1">MSDVKPDIKPETSEHVNLKVSSSDGSEVNFKIKKTTKMSKLIDAYCQRVGINPASVRFLFDGARINGDQTAADVGLEDGDNIDVMQEQTGGLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI17</accession>
    <name>A0A0D2WI17_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365755.1">
        <property type="nucleotide sequence ID" value="XM_004365698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI17"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI17"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="676" mass="74228" checksum="EE8D55BC10D9899B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI45</accession>
    <name>A0A0D2WI45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI45"/>
    <dbReference type="eggNOG" id="KOG1044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI45"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI45"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF17">
        <property type="entry name" value="DEMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="34700" checksum="3C06558EE18940D5" modified="2015-04-29" version="1">MLATVREGRELSQWQDIPQCMPGLLGNMMDHEGQLYCLDDYNTLFGKKCGTCGEFLLGEFTSVGETYYHLTCMKCAGCKKPIEHGDSFGDCADGFVCDTCCDRVCPQCDRPTHDNDAFLCEGEVSGWYHKHCLRCASCDKTLTAQSYRPYNGNPYCEEHFKLVSKTTVNLSSTCAACNKRIDSSGIRALDKQWHVACFACAECKEVINGGFIEHNGKLYCSNDYEKKYAPKCFACSQALVGSFMEVDGQKFHPNCIVCVACHKGFGSGQNIRFRGKSPYHMDCLTCVQCRKPFAVGAAMYSVNGQLLCGNCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK25</accession>
    <name>A0A0D2WK25_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Thrombospondin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Thrombospondin, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001829</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364697.1">
        <property type="nucleotide sequence ID" value="XM_004364640.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK25"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK25"/>
    <dbReference type="OMA" id="CPAKCCT"/>
    <dbReference type="OrthoDB" id="10062690at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395649" evidence="11">
        <location>
            <begin position="25"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1952"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="2087"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1929"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1983"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2199"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1993"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2011"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2027"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2199"/>
            <end position="2210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2254" mass="228530" checksum="22CD914BA7465F61" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK81</accession>
    <name>A0A0D2WK81_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364757.1">
        <property type="nucleotide sequence ID" value="XM_004364700.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK81"/>
    <dbReference type="STRING" id="595528.A0A0D2WK81"/>
    <dbReference type="InParanoid" id="A0A0D2WK81"/>
    <dbReference type="OMA" id="IKFTQWK"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="66" mass="7599" checksum="F9A92A9BEF7B4D56" modified="2015-04-29" version="1">MSKGSFWRAAGLNYLEYSNLAARYLRRALKEAPQAKALKREEHNLRVSLYENGKATPAKFLKNTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKL9</accession>
    <name>A0A0D2WKL9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin thioesterase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C65 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364373.1">
        <property type="nucleotide sequence ID" value="XM_004364316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WKL9"/>
    <dbReference type="MEROPS" id="C65.001"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKL9"/>
    <dbReference type="OMA" id="KVYCRQE"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000780">
        <property type="term" value="P:negative regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="61"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="33278" checksum="BB8E7A7B88FB222B" modified="2015-04-29" version="1">MASSAYSDFDVIAQEERVRDEIAASSELVSDPLPTSVLLDEYKENKDAFRDKLKDVTSKYDSFRRVRGDGNCFYRAFGFALLQQILHRGTEEQARKLYQQAVASKALLVAQGYTEYTIEDFYDSYVEVIALATGFPKPPAAYDYSTGIPVPVQQDANSEPPKQLPWPLTAQERALRESNLLAIFRDDPVASAVVYYLRLLTAGHFKTNAEFFQGFIEDGLTVSEFCAREVEVMARECEQVHIVALSAALDVPVRVVYTDSSDSTSQATEINFQEEGTAAPTVSLLYRPGHYDILYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKR2</accession>
    <name>A0A0D2WKR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364458.1">
        <property type="nucleotide sequence ID" value="XM_004364401.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKR2"/>
    <dbReference type="FunCoup" id="A0A0D2WKR2">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKR2"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKR2"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254534" description="Endonuclease" evidence="12">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="14">
        <location>
            <begin position="106"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="13">
        <location>
            <begin position="107"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="35550" checksum="EC635A6E211EA164" modified="2015-04-29" version="1">MLARLRLGAVVAASFGAGVACSQVDQPTAAAAAGSLLQWRWASSATQQNADAGDGDAGDGDAVRSGAGRSMRFGLPQVYAGEAPKQGLPPLQVMRYGFPDMGSIKYREGYIMSYDRRNKTANWVCEHLNAERLAVQEAKRDGMAFKEDDTDPELFRARLADYRGSGYDRGHMAPAGNYKWSTKAMEDTFYLSNMSMQVGKGFNRDKWEELESYVRSLTKTNRNVYVCTGPLYLPRQEADGNMYVRYKVVGPSQVAVPTHFFKVAVVEAPNGNLTIQSWVLPNEVIPNDTPLTSFKRPLAEIERRAGFLLYNSIPDKYTRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLD2</accession>
    <name>A0A0D2WLD2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349263.1">
        <property type="nucleotide sequence ID" value="XM_004349213.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WLD2">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLD2"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLD2"/>
    <dbReference type="OMA" id="CMEARRR"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="566"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="566"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1509"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1627"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1681"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1880"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2082"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2527"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2674"/>
            <end position="2729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2876"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1527"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1685"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1896"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1908"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2085"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2527"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2698"/>
            <end position="2727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3095" mass="333144" checksum="7A632F8A2ED30F0A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLI9</accession>
    <name>A0A0D2WLI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002587</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="9"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349337.1">
        <property type="nucleotide sequence ID" value="XM_004349287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLI9"/>
    <dbReference type="STRING" id="595528.A0A0D2WLI9"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLI9"/>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="300"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="423" mass="43368" checksum="2971A2C93F0473D9" modified="2015-04-29" version="1">MERLSNLAGHLLANGPAPAAASAAPSAAAFPKRDDDVVIVSAVRTPITKAKRGGFRDTPPDDLLAAAMQAAVQRANVDPKLIGDIVVGNVLQPGAGALTSRFAQFFAGIPETTPIVAVNRQCSSGLQACANIASSIRFGTIDIGLAAGVESMTQAPMTASVPENLNPRVGTNDKASDCLIPMGITSENVAARYGVSRADQDAFAALSHQRAAKAQQEGLFANEIIPVTVTVTDKEGNEKQVTVSADDGVRADTTAASLSKLKPAFSADGSTTAGNSSQVSDGAAAVVMARRSVAVKLGLPILGTFRGFAVAGVAPDEMGIGPAVAIPAALEKAGLRVSDIDIYEINEAFASQALYSVRKLGIPMERVNPKGGAIALGHPLGCTGARQVSTLLYELKRRKQRLGVVSMCIGTGAGAAAIFEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLQ2</accession>
    <name>A0A0D2WLQ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349418.1">
        <property type="nucleotide sequence ID" value="XM_004349368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLQ2"/>
    <dbReference type="STRING" id="595528.A0A0D2WLQ2"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLQ2"/>
    <dbReference type="OMA" id="REHSHIR"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15551">
        <property type="entry name" value="PHD_PYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="621"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75132" checksum="6359A689EDB4480C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLV3</accession>
    <name>A0A0D2WLV3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxisome assembly protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349484.1">
        <property type="nucleotide sequence ID" value="XM_004349434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLV3"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLV3"/>
    <dbReference type="OrthoDB" id="77656at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037485">
        <property type="entry name" value="PEX22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22978">
        <property type="entry name" value="HAD_Pex22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21954" checksum="5C5BEB9C7FD737D5" modified="2015-04-29" version="1">MAKYKWWELAAVMAVVAVGAGAYIIVKATSRRRPANVPNAPVPGGEPAAGRATNARPASAAASPSRPRMTCAALNVVLRRDATTGKLTVMAESLAHVLSMSSHFTIVLIQQCASDADEDSARQALEEAGAFQNGLLRNNLLFCDTPEGLMHMARHLEPALHVDTDAEVVKTLAPHVQNVVLVAEARPSNALPPTVFVVRNVREVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMW7</accession>
    <name>A0A0D2WMW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364157.1">
        <property type="nucleotide sequence ID" value="XM_004364100.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMW7"/>
    <dbReference type="STRING" id="595528.A0A0D2WMW7"/>
    <dbReference type="eggNOG" id="KOG4261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMW7"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17090">
        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="511"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="850" mass="90602" checksum="850778FF3A75A3EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN02</accession>
    <name>A0A0D2WN02_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364212.1">
        <property type="nucleotide sequence ID" value="XM_004364155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN02"/>
    <dbReference type="InParanoid" id="A0A0D2WN02"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN02"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="683"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="756" mass="81395" checksum="F25CB865FADA508B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN14</accession>
    <name>A0A0D2WN14_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364231.1">
        <property type="nucleotide sequence ID" value="XM_004364174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN14"/>
    <dbReference type="InParanoid" id="A0A0D2WN14"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN14"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="364" mass="38940" checksum="09496BB47E2D4844" modified="2015-04-29" version="1">MSVVTAGFTVSGGGASGAHTASVQQQPASSVSPLSHAHISSSHLELPKTHCLVTQVSYLGKVAKHCADKSYQSARAAAKSAIRSGQDPATLFLLAEQEDRTDNARRQDILLDEISTVHGVSCWRLHPKQLEKPDPACKLLSGQPQPPIDPNIFHINSDLPVEADENQHMLLGPARDMPRAVFETALSRLIEQSPSCMEMHVAPAGDPATLVEPMANLELGASSVPASASASSAAPLTLPALSDSVAMFLNGNLSEGPLDFIERDGLDSISCLLLDALDWTIFLPHISAAEKAVAYYIATRIVGQNTVELLSERSTLWWFVRDALTRHPTTDDREINVQACLIEHLDCLIGLGQGASAPLSKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNC0</accession>
    <name>A0A0D2WNC0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348406.1">
        <property type="nucleotide sequence ID" value="XM_004348356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNC0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNC0"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNC0"/>
    <dbReference type="OMA" id="ASITWHH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20660">
        <property type="entry name" value="CYP4V-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836557" evidence="14">
        <location>
            <begin position="16"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="58779" checksum="30B51DD82102C56C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPZ8</accession>
    <name>A0A0D2WPZ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363538.1">
        <property type="nucleotide sequence ID" value="XM_004363481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPZ8"/>
    <dbReference type="FunCoup" id="A0A0D2WPZ8">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPZ8"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPZ8"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPZ8"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="120"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="580" mass="60856" checksum="23DBFA9AA502AF06" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQB2</accession>
    <name>A0A0D2WQB2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347305.1">
        <property type="nucleotide sequence ID" value="XM_004347255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQB2"/>
    <dbReference type="InParanoid" id="A0A0D2WQB2"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQB2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="290" mass="32101" checksum="F1A86F00034511C6" modified="2015-04-29" version="1">MGAALKRLFPGPVFLPSGGTELEYIVWMLEWCARANQCTCKKRAGETIVAMALHSRVSGDPHRQFAGSLPLQASSQSAQMQLHYPRAVTIDKRREELRAQDATHDAQAELAKLDDDRIAKDTELQSLAKPKRRRLPRQPRPVSPSITAATKPSTARRARRAAAEDDSSSDSDSQQASNIGHEADESGYDSDDNERVLQVTRTDSQSDGEVHFALKALETREIADNIRPRPFRAARRLGIDALGDINNPVNKRVRLDTEAHAVEPPPMTVNLTELLRHQMFVPASSCPNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQB4</accession>
    <name>A0A0D2WQB4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363645.1">
        <property type="nucleotide sequence ID" value="XM_004363588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQB4"/>
    <dbReference type="STRING" id="595528.A0A0D2WQB4"/>
    <dbReference type="eggNOG" id="ENOG502S80V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQB4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254682" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="31"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="747" mass="80904" checksum="1403EF9D8988A242" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQR7</accession>
    <name>A0A0D2WQR7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQR7"/>
    <dbReference type="STRING" id="595528.A0A0D2WQR7"/>
    <dbReference type="eggNOG" id="KOG3588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQR7"/>
    <dbReference type="OrthoDB" id="5971499at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF5">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PA14" evidence="9">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="635" mass="72031" checksum="B10B83B0937840FB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQY8</accession>
    <name>A0A0D2WQY8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Preautophagosomal structure membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348117.1">
        <property type="nucleotide sequence ID" value="XM_004348067.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQY8"/>
    <dbReference type="FunCoup" id="A0A0D2WQY8">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQY8"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQY8"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQY8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.620:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="8">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="7">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="6">
        <location>
            <begin position="184"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="310" mass="35148" checksum="A112C8883EA67D2A" modified="2015-04-29" version="1">MADDREIERQIWEGKVPIVFNLAQSEVTGDEPPEPYYLLAPRCSYLPLVTTKVKKHFQSTGTDTEDEMWFDYAGQALKWHYPIGVLFDFYGSPSQLPWSVTVHFQGFPEDEVLRCPDKETVETHMIATIKEADYLKNGSTKKLLAMLKKDQKQLWMGLKTFKFDQFWSVNKRLTQRDETDPFKNVPFRIYVPDQPVLQEPFPPFRQDGSEYTLGDLLATVLPELFPAERVSPFLVAFNAAAAEARAAEGGAPEDVPVAPPSSLGKQVELPQIVLHGISPAFETPLLWLGEHCCYPDNFLHICILPSELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS11</accession>
    <name>A0A0D2WS11_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS11"/>
    <dbReference type="STRING" id="595528.A0A0D2WS11"/>
    <dbReference type="eggNOG" id="KOG3345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS11"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="241" mass="26676" checksum="EB0A11C3F9846E45" modified="2015-04-29" version="1">MKELQRFRQRKSGVTPAGLALGQRVKSVAEELLAASDPFKLKSGGGLVDKAAIRVKDRDRDRDADDDKNFSLTSTFSHETKARDEDKMMLSYIDEQLAIRRGTNANDNANNANDPTAQLYVVPKNLEATSALKNVSEDSISSALLSGIPEVDLGVQSRIRNIEETEKARIELEQKRLSGNQSSNVVLHHHRFFNTADRSDRSDSAGAQQHGSQNSSAAARQPRATDQLVFDKFKKAQLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS31</accession>
    <name>A0A0D2WS31_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346121.1">
        <property type="nucleotide sequence ID" value="XM_004346071.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS31"/>
    <dbReference type="STRING" id="595528.A0A0D2WS31"/>
    <dbReference type="eggNOG" id="ENOG502RDHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS31"/>
    <dbReference type="OMA" id="RMSGIQE"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS31"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="37260" checksum="E25565D4379AFE71" modified="2015-04-29" version="1">MSSDYERQRQANIRANMERLAMLGLAKGPVAASAAAVAGKVAAASPRAAARRNTVAVGEAPSPAETAPGTTLRRSSRSRTSTLRYEPEQEDDVQDERKPAAPRTKQSPKVKHGGESSRPSSSSSSGRSCKDMMACVETLQTTWLGRQLPLPAVGAGLKTAVMALVAGTRSAPAFPRLSGVQQWKNAVCLFVNLDGNTYDNTFSQAQGGFAMTWFASAQTNMDSPVIQRLLKAERYDLKNDDSAPSRQSTEAGLHKPEVVLLFCRLLMEPYVYCGRLALVWVDPKTSPLKFTWFLKDSSSMMASCPDFQAMLPPQLGGTRGTSNDDDSANEDEEEEEEEEEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS78</accession>
    <name>A0A0D2WS78_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS78"/>
    <dbReference type="STRING" id="595528.A0A0D2WS78"/>
    <dbReference type="InParanoid" id="A0A0D2WS78"/>
    <dbReference type="OrthoDB" id="10065861at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS78"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11763">
        <property type="entry name" value="SH3_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="8">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="500"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="665"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="81040" checksum="293A7BA85EFF0023" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSY7</accession>
    <name>A0A0D2WSY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSY7"/>
    <dbReference type="STRING" id="595528.A0A0D2WSY7"/>
    <dbReference type="InParanoid" id="A0A0D2WSY7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="526"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="654" mass="72051" checksum="47005D56C1FAA724" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT51</accession>
    <name>A0A0D2WT51_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347031.2">
        <property type="nucleotide sequence ID" value="XM_004346981.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2440"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2448"/>
            <end position="2475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2486" mass="269128" checksum="57C40833411A283E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT62</accession>
    <name>A0A0D2WT62_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT62"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT62"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT62"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="70122" checksum="AE4A046A9AA35082" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUE3</accession>
    <name>A0A0D2WUE3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUE3"/>
    <dbReference type="FunCoup" id="A0A0D2WUE3">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUE3"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUE3"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUE3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254668" description="GTP-binding nuclear protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="323" mass="37308" checksum="3BB2362BF618D394" modified="2015-04-29" version="1">MSRIIFLLQWGWWLAGNTCRITHTHRQKAANCSKIRNMVEHFFGGFKMTLLRSPPWVSTLPKCLFPSRSTQIRRWFVFRHSSNRRDCLPKSGIQLTFCFLTFSQFNSTMENQDIPTFKLVLVGDGSTGKTTFVKRHISGEFERKYVATIGVEVHPLLFHTSFGAIKFNVWDTAGQEKFGGLRDGYYIQGQCAVIMFDVTARVTYKNVPNWYRDLTRVCEHIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLAKKLIDPSLEFVSMPALKPVEATVDPALIQQYEAELEEARNTAIPDADDDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUF5</accession>
    <name>A0A0D2WUF5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345591.1">
        <property type="nucleotide sequence ID" value="XM_004345541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUF5"/>
    <dbReference type="STRING" id="595528.A0A0D2WUF5"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUF5"/>
    <dbReference type="OMA" id="CHACRNI"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUF5"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="642" mass="67203" checksum="F2155FAA7651CC52" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUG2</accession>
    <name>A0A0D2WUG2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344278.2">
        <property type="nucleotide sequence ID" value="XM_004344228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUG2"/>
    <dbReference type="InParanoid" id="A0A0D2WUG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="334" mass="35151" checksum="BC39F18B65EC3514" modified="2015-04-29" version="1">MQQIFPSSSPKPGATRLSDAFSDRDYVEPGPLSRGMMASLVAPSGEYSYASSGSSSSNGNTSCVPLLFWPSSAPASAAVSSAPLLHPSSTSFLASNSSTLADGHSPGDLPRNFALRKRRFNDDDDDHNYQMHGTDGGDGGDGDDHNCYGEMAPRKRVALASDDEDKVFGADSGWRPTHLAAANRETLGQCDAGNSSSFILDDQGQALPAPWPHSLSASSAVLLESSSLELPQPGYIVESVGQTALRTLDPTQAQAVSEIAETSASQHDQQLQQPRLVLSTTSDSHSQTAPLEPFQLPAGFALGEGDSAALSNSSYSSINKLLGQLHLSRKSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUQ9</accession>
    <name>A0A0D2WUQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344391.1">
        <property type="nucleotide sequence ID" value="XM_004344341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUQ9"/>
    <dbReference type="STRING" id="595528.A0A0D2WUQ9"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUQ9"/>
    <dbReference type="OMA" id="WGQRFPP"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="27955" checksum="575F814809DC8BD4" modified="2015-04-29" version="1">MHLRLDGKLVLVTASTGGIGEAIATSLAREGARVIVNGRSQASVDAAIARIRVAVPGALLEPLAADNGTAEGNAATVRHFPDVDILVNNLGIFNAVPFFELSDAEWTDMFQVNVMSGVRLSRHYLKRMIARNEGRVLFVSSESGVSPDPDMAHYSATKTTQLSLSRSLAQLTQGTNVSVNTVLPGPTRTDGVVQLVKNLFPDVPYAEAERKFMHENRPNSLIARLMAPEEIADAVTFLASPLSSAINGAAIRLDGGLVRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUR3</accession>
    <name>A0A0D2WUR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344397.1">
        <property type="nucleotide sequence ID" value="XM_004344347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUR3"/>
    <dbReference type="STRING" id="595528.A0A0D2WUR3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUR3"/>
    <dbReference type="OMA" id="HCNLREI"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255263" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45722" checksum="369A56102F42A2E7" modified="2015-04-29" version="1">MNSKSSTRFALFLLVCLACLSGRALADDACTVCVCGADSVTNCQSTVTTIPTAIPSTTVLLDLSNTQINEIGVDAWAGLTALKTLNLTFTQLTSIPDNSFSDLSALENLYLSHCPISQLSTNSFAGLSELRVLRLINTTFETIPDNVYSPCPKLKALWLDYCKVKVFNDNCFTGLGELTFLSCYNSSVANISENAYSSLTNLEYLNLNYTKIQHVWPKWFTNTKKIQILYLSWTNITSIPADAFTGLTGLYQLYLYSAYNLTTLPPGLFYGLTNLTLVKLEPNYFTGYAAPPSTYGPPASPLPCNYTCKTCYGGSATACCGTDCLYCDTNNPCLTVPPSYSYYASSVEKPSTYIPPAESSVYVPPAESSVYVPPAESSVYVPPPPIDSPYVPYGNGASETAADSTTALMTFASVVVTAWALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUR7</accession>
    <name>A0A0D2WUR7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUR7"/>
    <dbReference type="STRING" id="595528.A0A0D2WUR7"/>
    <dbReference type="InParanoid" id="A0A0D2WUR7"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="289"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="373" mass="40951" checksum="4628A673B47D9EAF" modified="2015-04-29" version="1">MATVEALTDSIRVTAQQHQRLTDLRRREMERSWLIHQALALAEASMLLGVLPAQAAQALQQPVAIPSIADTMITANDLCMAFRLEALEKRSSHRRAVSLHVKHEFAVHYLLNSISSLAHELQLMKQEGLYQDDTEDVMARIDPNVLEAGLSQSTNFLERAVAEPSLCRMYLLQLAHLVGQLNDKTMTYLVGVKPGSTAQHERELQLQQQQQQLQQQQQLQQGSGQGTQNNAHMQVAAAVSASSNMTMPLGTRATSISAQSSAAYLAAAGNNGDPGVSAASASLQPDEQFALDVVVDEARTVGSGLNAFTLYSCIALRSNGPNLVVARRYNDFVKFRELLVDRNPSLRDNLPKLPEKKVIGMFTFAYQGCDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVY7</accession>
    <name>A0A0D2WVY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione synthase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_006837</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344458.1">
        <property type="nucleotide sequence ID" value="XM_004344408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVY7"/>
    <dbReference type="FunCoup" id="A0A0D2WVY7">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVY7"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVY7"/>
    <dbReference type="OMA" id="TCIRENA"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVY7"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="18">
        <location>
            <begin position="393"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="403"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="458"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="588"/>
            <end position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="650"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE96528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="663" mass="70185" checksum="8231C62106412D42" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW85</accession>
    <name>A0A0D2WW85_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras like enriched</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW85"/>
    <dbReference type="FunCoup" id="A0A0D2WW85">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW85"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW85"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW85"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="163" mass="18193" checksum="F0E763C307DCED86" modified="2015-04-29" version="1">MQFIEGQFSETYNPTIENTYQKPLSLRGGRDFLVEIVDTPGQDEFSIFPTRYSVGIHGYVLVYSVTSRTSFEMLKIIREKLLNMTGTNSVPLVLVGNKTDLVGERVVTFEDGRELAAQWGCGFVESSAKRNNSVKEIFESLLEEVDKDSLPPQKDKSGGCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ7</accession>
    <name>A0A0D2WWZ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LUC7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343518.2">
        <property type="nucleotide sequence ID" value="XM_004343468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ7"/>
    <dbReference type="FunCoup" id="A0A0D2WWZ7">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWZ7"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWZ7"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36751" checksum="F3452CBE593ADD30" modified="2015-04-29" version="1">MSANRALLDELMGVNRNALPHERKREREWPDDDVCKHYLCGLCPHDLFPNTKMDLGKCAKVHDDKLREAYQTSSRKGELGFELAHNNFLEETVRSVERVIRANTERMHVGPGSEAQRQQDRAQRIARVNEQIAELTSRAQDLGAQGQVDEASAIMRDIERLTNDKTKLERPDEDGRDNSLEVCQICGALLIVGDAQERVDAHIQGKVHVGYALIRDMLAKYKQEGFPTALRGPPRPFGRDDDRDRDRDRSDRGRDRDRYDDRDDRRRRSYHDLDRDDRSYGRSRDRSRSRSRSPRRSYSGRRDRSRSRSRSPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXE7</accession>
    <name>A0A0D2WXE7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXE7"/>
    <dbReference type="InParanoid" id="A0A0D2WXE7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="228" mass="25848" checksum="BA7EAD5243E14E32" modified="2015-04-29" version="1">MSRNSRSEPRSEAAVSAAFTDIHQVSPGDMVRALALLSKLPHASEKVQAYVTRSMFVYRKKIRQPWEDLSKVKANKGAFKLYTGFYLATSWEAVKKSFDVLCGVDPEPEQTYRYRALCAAENCAPQPVSEPPVEVDDELKILLVTYIETIITSIILELNDAEGWKEEASRLARFPQAQLTFDFIGNAIELMQSLHTLTNGRQRYRDIINSTLAFQDTIYELPSTKTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYJ3</accession>
    <name>A0A0D2WYJ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342676.1">
        <property type="nucleotide sequence ID" value="XM_004342627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYJ3"/>
    <dbReference type="InParanoid" id="A0A0D2WYJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="447" mass="48034" checksum="A739EE10BBEC5DED" modified="2015-04-29" version="1">MQPWRQFGFGATTRDPATKQQRVASPDHSSSSASCVSADASTRSQTTTMTTTTRTDDAVLAWMLAFACERRDRSFVQALATVCPVERLEPPDGLAASTSHGLIITGLSELAERGKASELPAALNLLEAIGPICYDSSQPQTILTPPDPHKYFELTTDLRTEAIMTELGSAPFNIDRCILAMNRFLPTKLDAATSAWSERVDELEHPTFHSALHDALGTRALLRRRLMRVFLQDEQRLAIVAQHRACKLLSVCWSNVTKFVQALHCRPLAARMLLAHVSTLRLSEPRYERVGIASGSDAPFPAPSNRSRGRRNTQTKALLRSLSPDRPAETAVAPTLAAALPTAGRSNGSMAVAEAELSDEFASSQQLILFAADASFALAAAAAAAAQEPSRTGSAGSPMHSSQASSAGSQTGIQMFSQRTQPSVGVKRRLSLPALDDSPTSSRARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X031</accession>
    <name>A0A0D2X031_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364883.1">
        <property type="nucleotide sequence ID" value="XM_004364826.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X031"/>
    <dbReference type="FunCoup" id="A0A0D2X031">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X031"/>
    <dbReference type="eggNOG" id="KOG2811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X031"/>
    <dbReference type="OMA" id="TICEYIV"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X031"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="14">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="611" mass="66233" checksum="D2668F31509B05A0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U8</accession>
    <name>A0A0D2X0U8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365989.1">
        <property type="nucleotide sequence ID" value="XM_004365932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U8"/>
    <dbReference type="FunCoup" id="A0A0D2X0U8">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0U8"/>
    <dbReference type="InParanoid" id="A0A0D2X0U8"/>
    <dbReference type="OMA" id="AAWPSWI"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="300" mass="31592" checksum="4893FD1D5CDFB637" modified="2015-04-29" version="1">MSITFDWAKIKPAHADLLKDLLNAKLREAASSKVLPDLLGPIVVTEVALGSTPPRVDIEALSDPLALFSDPALAVQFATVVGGKRKAEPAKSSSDVASSDSSSATGDTQLQPPRLAPPAGKRPSPFANLGAKADASSPPSQPTLPAPPPSITVADPDAVQLQFALAYTGDVTITVETDIRVNTPVPGFISLPITLGVTGLNVSGRVIAAHNMREKTVCVTVLPLNSSTSPLADLRLKTTLGDPDKKLLKHIEQLESFIVRQLRQVIHEKVVYPRFIKVLLDKSAGKNSDASDSTKGPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0V4</accession>
    <name>A0A0D2X0V4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366016.1">
        <property type="nucleotide sequence ID" value="XM_004365959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0V4"/>
    <dbReference type="InParanoid" id="A0A0D2X0V4"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0V4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="268" mass="30154" checksum="9F935BB6F94F19DD" modified="2015-04-29" version="1">MGRLRAVATKIADAVPLRNRTKIVSRRILKAASEDNASRLQEILLRHPTSIESCDKEGNSALHICVDSSARYGNSADYYRCARLLIRNGVNIRARNASGKTALDLARDFKMKEFVALLSDQKLQQAEKENVTKLENRVSDNIVDTKTVVNPELRVKVFELISSEWKAVGTGNIRLQMSNRSFIFIDDFNNVLLTEHLYDFDSDATSCGLCEMVQDKNVKIAIKDSHSGALKVLLVRLKDHYDASILFNNLQQCRQSLRGGVRKQSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X117</accession>
    <name>A0A0D2X117_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349930.1">
        <property type="nucleotide sequence ID" value="XM_004349880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X117"/>
    <dbReference type="InParanoid" id="A0A0D2X117"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255413" evidence="2">
        <location>
            <begin position="29"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="432" mass="44803" checksum="8669F37DA2F9AE39" modified="2015-04-29" version="1">MQTPFFAKPLATACLVVALLSMPCLVTCAPVVQQDVALGASGPSGSDLANQPVLCDDSKLCQTKPASFARLAPATANVLAAMIARIFSGSQEHPAAAAGSASAAAGEANPVVGGLRRQAEVRDFARPDPNLIATQMGSLPTTSTSTVVVGVVIALCVVSSLLWMCANHKGSSKESEAGDAHANVNHSPKNGSPKNGSPKSTIPQQQPQGDRRLSVSSSQQRRASHSSVSSNAPNIRATRPAAVDSPAMASLLQAHPPADAQSISSLNLPNRGDGNLSASYLSPGAFFEQPGSYGSTELNRGRRPSDATVLSELSFNRRSQYADVMPTGNEKPNEKPMEHEDTTPTLLESVVRRMPDLARHAPEARPIQYVVLELPVPPPAAASRKSSASADAAPMTLSSLPVPAVPGSESKPYQSGASVYGARRPKSVSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1G4</accession>
    <name>A0A0D2X1G4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348769.1">
        <property type="nucleotide sequence ID" value="XM_004348719.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1G4"/>
    <dbReference type="InParanoid" id="A0A0D2X1G4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="484" mass="54612" checksum="17499AFD11B550ED" modified="2015-04-29" version="1">MAFIGYPSPTGMVDHQAAYPQPFMYPMTPQQPHAAGCYTMPPTPVSSASSSASSMPPVVASTMSTNDAAAALQIMQRSPVTHRTQPVAQFASAQPSNPTYTYPYYVQPQQVQPQQPQHIQHVPSAFTQPSYQQQHHHQQQHQPQLLVQQAYHAQPQQPQLLQQPQQMQQMQQLHMQPAYQQQQPQQPQQLQQQQMYLPQQSQHFLPLQSQHYYQLHMQKLEHAAVQYNDVTPPLSTTSLQAPVNLFQQQRPPVAHAANRLPSPAPSGSSVASESVRRSLSPAASFADQGPGVVNASRVRKASSSTKNRKAARPNPIYLDNEVPVIKYAKPTQHSKFVIGSITTELDARFFFAECMEGRIHLNACRLDRDAPTEVEAGQIYVFQSEERPSTDGDAQPAPATKADSKTKSSLKRWTDTLQWNSRKYWHLKNILKYRQTMPHPDFPTDPKQNIIKPDGLTKMIICGTDKYSHLRAVHYFYDTSRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q2</accession>
    <name>A0A0D2X1Q2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349119.1">
        <property type="nucleotide sequence ID" value="XM_004349069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Q2"/>
    <dbReference type="InParanoid" id="A0A0D2X1Q2"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="720" mass="77599" checksum="FF4E8CA705701AD1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2C7</accession>
    <name>A0A0D2X2C7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364156.1">
        <property type="nucleotide sequence ID" value="XM_004364099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2C7"/>
    <dbReference type="FunCoup" id="A0A0D2X2C7">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2C7"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2C7"/>
    <dbReference type="OMA" id="IRWWREE"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2C7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="359" mass="39498" checksum="B683ABCC97D05016" modified="2015-04-29" version="1">MAAARFRTVFDVSGLARPNWFPGHMARGMREIARNLQHIDYVIEVHDARVPVSGRNPLLQALQKPSTLLLNKMDLGDPAVNKIAKARLHEINPRHNVVLTSATLRLERALTLVVDHILANVPAERADKDGEGIHAMIVGMPNVGKSSTINALRRLLTGEGARAKVGPIPGITRAVMQPLHISRDPKIMLIDTPGIMAPHIPNVEVGLKLAAVGTFIDHQVGEALIADYILFSLNLRRKFDYVKRYNMDQPCDDINVFLSALAQHSGLVLKGGLLNTTLAAARFIKDYREGALGRLTLDDAIVEGGLPAIVAAQTAQASSPKASEQARLPPLDEENWNPVDAFDRLRAEEKRLRGFKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2C9</accession>
    <name>A0A0D2X2C9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003325</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364164.1">
        <property type="nucleotide sequence ID" value="XM_004364107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2C9"/>
    <dbReference type="FunCoup" id="A0A0D2X2C9">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2C9"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2C9"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2C9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="417" mass="44864" checksum="010D0290B3D2F2C6" modified="2015-04-29" version="1">MALNKLGIRDLDLAGKRVLIRVDFNVPLDKKQNITNNQRIVAALPTIKYALENNAKAVVLMSHLGRPDGRRLEDQSLAPVAKELEKLLSKPVQFLNDCVGEEVEKACANPAQGSIILLENLRFHLEEEGKGLDKDGNKASATKDQIAAFRASLTKLGDVYINDAFGTAHRAHSSMVGVNHSQRAAGFLMKKELDYFAKALDHPERPFLAILGGAKVSDKIQLINNLLDKVDEMIIGGGMVFTFKKVLNNMEIGKSLFDQEGSKIVQDIIYKAKEKNVKLHFPVDYITASKFGADAETGVATDASGVPADWLALDCGPESAKIFAEAVGRAKTVLWNGPMGVFEFEKFEKCTKAVMDAVVASTAKGTITIIGGGDTATAAAKYNAEEQVSHVSTGGGASLELLEGKELPGVTALSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2J9</accession>
    <name>A0A0D2X2J9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363333.2">
        <property type="nucleotide sequence ID" value="XM_004363276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2J9"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2J9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="970" mass="102609" checksum="FE178F237C37EEAB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2W3</accession>
    <name>A0A0D2X2W3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347896.1">
        <property type="nucleotide sequence ID" value="XM_004347846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2W3"/>
    <dbReference type="FunCoup" id="A0A0D2X2W3">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2W3"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2W3"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2W3"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000018">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="250"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="359" mass="39377" checksum="B81C5973C49F04F6" modified="2015-04-29" version="1">MKALILVGGFGTRLRPLTLGLPKPLVEFANKPMLLHQVEALVKAGVTHVILAVNYRAEVMEKELRSFEQTYNIKISISQETEPLGTAGPLALARDILNEGDSPFFVLNSDVICDFPFEEMVAFHKAHGKEGTILVTKVDEPSKYGVVVARPDGCIQKFVEKPQVFVSNKINAGIYLFNTAILKRIELRPTSIEKETFPAMAADQELFAMNLEGYWMDIGQPKDFLAGSALYLESMRAKNPSMLAKGDNFVGNVLVDPSAKIGTGCKIGPNVVIGPNVIIEDGVRLAKATILNGSRIKSHAWLTSSIIGWRSTIGQWVRMENISVLGEDVMVKDEIYINGGMILPHKEIGTSIPEPSIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X346</accession>
    <name>A0A0D2X346_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X346"/>
    <dbReference type="STRING" id="595528.A0A0D2X346"/>
    <dbReference type="InParanoid" id="A0A0D2X346"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X346"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="488"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1205" mass="126889" checksum="98006CBED032F1EE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3J0</accession>
    <name>A0A0D2X3J0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346723.1">
        <property type="nucleotide sequence ID" value="XM_004346673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3J0"/>
    <dbReference type="InParanoid" id="A0A0D2X3J0"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="146" mass="16283" checksum="B84C9BAE734B2698" modified="2015-04-29" version="1">MSSSDNHPPQPPTAPLLVKHTAASAYPDVDGHLRELPLRNDARSMSLVFFPAGTVEPWHHHSNSDNMYVVDGTIRVETKPGSSGGDQQQQQQYELSKGDFFYMPANVPHQVTYVSDTTFLYVNDGVFDGPHWDSEVKETIYPPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3M5</accession>
    <name>A0A0D2X3M5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3M5"/>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3M5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1644"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1678"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="3">
        <location>
            <begin position="1477"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1729" mass="187339" checksum="EFF26FA4161CB6C2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3S8</accession>
    <name>A0A0D2X3S8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346079.1">
        <property type="nucleotide sequence ID" value="XM_004346029.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3S8"/>
    <dbReference type="STRING" id="595528.A0A0D2X3S8"/>
    <dbReference type="InParanoid" id="A0A0D2X3S8"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="704"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="871" mass="94126" checksum="0CDB5F2A1B156A02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3X7</accession>
    <name>A0A0D2X3X7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346244.2">
        <property type="nucleotide sequence ID" value="XM_004346194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3X7"/>
    <dbReference type="STRING" id="595528.A0A0D2X3X7"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3X7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3X7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006:SF606">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006">
        <property type="entry name" value="PROMASTIGOTE SURFACE ANTIGEN PROTEIN PSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="74"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="342" mass="37945" checksum="E8F94564A754F96A" modified="2015-04-29" version="1">MYIFKANCCNKTAKDQELAAKNQELAAKDHELKSALDRIDVLEREKEDSASASNFDGPIPQVSLATLVSVTNNFAADSLLGEGAFGRVYGANLPGPHVAIKKLSAESKQGPAEFKSELDSLSKFRHPNIISILSYAEEGDERCLVYEFMPNGSVRDRLSRKKDTPPLTWSQRHRIAADVARGMHYVQTAFPDHVLFHLDLKTDNILLDEHFNAKVSDFGLVRAAQHLHDKSYLRTQNVQGTAAYMCPEFLIEGRMTTKTDVYSFGMILLEIMTAAKPGPRLKNEMRKAVKNQAINGMLDSALNPTEAESQSVRELVTLALECLDDESDDRPSFGCLLATLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X449</accession>
    <name>A0A0D2X449_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345479.2">
        <property type="nucleotide sequence ID" value="XM_004345429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X449"/>
    <dbReference type="InParanoid" id="A0A0D2X449"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="414"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="473" mass="51202" checksum="751BBE924C743269" modified="2015-04-29" version="1">MTMDLDDSARASDGASNPNAAATTQQPPTAVVPVQQLRRRRTHHVAVQAPVDILLHPQARAARTSAASSQSITLDLDETGESTQKSSSSTTSSSSQPEPPARRHTIASDVSDGSLVSFMSLPASARQRQSTMMAVDSDDDDSGPNSDPFAVLQRPKGDSHYNKKLYGEFVITQEEAAAAAAAAQLVEESDDYEEPYPTRLQTRTAKRPRMDESPPSDDVSAQTAAALSAARLQRERAQHLLIEAQRSEMAESNEQQASESGPIPDASKVLARVVVVDGTPLHLLLTLDTTARTIQQFCAARLSVDPTHVALSFAQQTVDLNSTMRELNISPRNDLFQCQMAPPSPTTYDATPSLFANNPAFSNSSSSSAPPDLEPFANTTSSSSSSMVTDLPPPLPDTVEEPLSIRFRVRFDEHEVRKFRLKLTDTMSKVYDKIAADRAAAFKILFDGQPVPRNTTPEDLGLEEDDLLDVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4D3</accession>
    <name>A0A0D2X4D3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345011.2">
        <property type="nucleotide sequence ID" value="XM_004344961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4D3"/>
    <dbReference type="InParanoid" id="A0A0D2X4D3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="276" mass="29669" checksum="5BFA897725B505F1" modified="2015-04-29" version="1">MSTLLNFGAETPLVAFGFVSLLTIGIAFLVIIMFYGTVNNKKQAKQQEGRATTTTTTQKQQQQQQRKPQAQQPQPKQQQQQQQQQQQQQQQQQQQQQQQQQQKTKKVAAAATEVAKPIPVRGAVSASAPANGSSSSSSVNKGKGPATAASSSKPQQPQQPKKQVKIQDPLAADPHHNQPPRLKSPPPVLASTSVPAHSFAGMYEGDTPVRGPDEGWVTIERKKRPQKPAAATADAAAPPASALLHPSATPNGASILSRRRVSFGHVDTIPPPTFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Z3</accession>
    <name>A0A0D2X4Z3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras GTPase-activating protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343881.2">
        <property type="nucleotide sequence ID" value="XM_004343831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Z3"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Z3"/>
    <dbReference type="eggNOG" id="KOG2059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Z3"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Z3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05128">
        <property type="entry name" value="RasGAP_GAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF144">
        <property type="entry name" value="RASGAP-ACTIVATING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="9">
        <location>
            <begin position="414"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="672"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="100682" checksum="1896C59B11146739" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5D4</accession>
    <name>A0A0D2X5D4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343301.1">
        <property type="nucleotide sequence ID" value="XM_004343251.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5D4"/>
    <dbReference type="STRING" id="595528.A0A0D2X5D4"/>
    <dbReference type="eggNOG" id="ENOG502QS3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5D4"/>
    <dbReference type="OMA" id="HRKFEQG"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5D4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051549">
        <property type="entry name" value="PEP_Utilizing_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615:SF1">
        <property type="entry name" value="PPDK_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124059" checksum="6CE0188A409459AA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I4</accession>
    <name>A0A0D2X5I4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I4"/>
    <dbReference type="InParanoid" id="A0A0D2X5I4"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41793" checksum="B4CB3CC849A85CB8" modified="2015-04-29" version="1">MSERQRELYDEVKHASDWLWWTEKQIGNDGAQAVAEALKVNTTVTYLELRRNQIGDVGARAIAETLKVNKTVMEVALSGNQIGDAGAQAIAEALKVNTTMERLHLCNNRVGDAGAQAIAEALKVNTNLIWLHSPQPEILGWLVHIGALALAEALKVNKTLTDLTLENNCIGQVGIQALGEARKVNGILTKLDIQGQINPLAFSLLPRLATTEDWQSVFHLLTGRHELENQPALLPALPAEVAELVMHEAEYLQGVQHIHQAWSRNNQIDFLKLTMPRSSNGNSIRVKAIQVLREQSEAKSGRFDLIVRDELGAVRYKWAAEAPVVGSNIQLVTISPTDHPVIRQMREGWEVEVRFGQYYSFVRLASLSVGYIERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5M1</accession>
    <name>A0A0D2X5M1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5M1"/>
    <dbReference type="InParanoid" id="A0A0D2X5M1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18040" checksum="6139C06699F603B8" modified="2015-04-29" version="1">MTITGNRMLMLARVSALSSTARSLHTAPRLARQQGTLSTTAVPLRATQPPQTQPLLATRSMSTLFSSKTPVAFSKSAAARAELKDTFEGTPTSAYPRLVVVGGVLIVGFMVANMVFGERTEWPDSPILTPLRAKLDQVDEHHRYLVERQQQQQTSAAQRPSEPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5Q7</accession>
    <name>A0A0D2X5Q7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342480.1">
        <property type="nucleotide sequence ID" value="XM_004342431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5Q7"/>
    <dbReference type="InParanoid" id="A0A0D2X5Q7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="62" mass="7129" checksum="3D5A49C246274C8C" modified="2015-04-29" version="1">MQSVQVSGKATLFLMLTSFVAGLVVGFRINKLLREHTQAHVERKKRTQRAEIERLQQLHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0H7</accession>
    <name>A0A0D2U0H7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysosomal alpha-N-acetyl glucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365200.1">
        <property type="nucleotide sequence ID" value="XM_004365143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0H7"/>
    <dbReference type="STRING" id="595528.A0A0D2U0H7"/>
    <dbReference type="eggNOG" id="KOG2233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0H7"/>
    <dbReference type="OMA" id="YGQPFVW"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0H7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265327" evidence="2">
        <location>
            <begin position="23"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="165"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="507"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="786" mass="88061" checksum="3C4727DFDEA8EB1E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U325</accession>
    <name>A0A0D2U325_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365890.1">
        <property type="nucleotide sequence ID" value="XM_004365833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U325"/>
    <dbReference type="STRING" id="595528.A0A0D2U325"/>
    <dbReference type="eggNOG" id="ENOG502RETP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U325"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="19618" checksum="91547B38F23AFAE4" modified="2015-04-29" version="1">MSNNSDNDSDPTFSTGEKVAATGVVAASAAPVAVVAAVNAVGFGAGGIAAGSTAASMMSAAAIANGGGVAAGSLVATLQSVGTVSLVAAAGPLAVVGGAVAITVLAVAGWRIHAKQAKKEADEKKAQAEKKAQAEKKARDDKAAQDKLEADKKAQAATETLASSKDSVESDAKPQEAETEPAEKEAQDETAAQDKLATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3N2</accession>
    <name>A0A0D2U3N2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349767.1">
        <property type="nucleotide sequence ID" value="XM_004349717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3N2"/>
    <dbReference type="InParanoid" id="A0A0D2U3N2"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3N2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="290" mass="32238" checksum="EC34990FA2FA2DAB" modified="2015-04-29" version="1">MVLTLGDVIDGNSLLKDTLALPEDNPLRKWQVTDVVLIDKDPFQRAVLAELPPDRAATQRRLAALSLLQRLLEQEVGAPRTLIAQPREFDTRFMGVVNGVLALKDGAVVSTCYGKSKFSDALTTMDGLKTYLQDRLGDLSLLQVTTLDLSGNELLNEDLPYVCDVVNALQCPVVKLRSNRFGMGQPSTELNSPVHYLASMAASAYVRFVDIVGNYVVGVEWAPAYQRFANPTTWHKLVYIPLVWLKGHDWTKPDICGQYVTAAKDCHEDFYWANLSDPVFSRSDPLPALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4R3</accession>
    <name>A0A0D2U4R3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MADS box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364325.1">
        <property type="nucleotide sequence ID" value="XM_004364268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4R3"/>
    <dbReference type="STRING" id="595528.A0A0D2U4R3"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4R3"/>
    <dbReference type="OMA" id="HHPPADY"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4R3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="212" mass="22326" checksum="707B1EBE6037733B" modified="2015-04-29" version="1">MADEYTNVNPEDGGLSDGSDDSDGDTPVRRGSGRGRRKINIEFIEDKSRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVASETGHVYTFATPKLQPLITKPEGKNLIQTCLNAPDGGGIPSSAGSSGNSASAPAPQPPAPSMQGNPSMPQNNQGRAPNSGYPESYSYGTGEEDKSQMPAAYPGMHPGYYPAATAYPTYGAPGGYQQGGYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5D3</accession>
    <name>A0A0D2U5D3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364547.1">
        <property type="nucleotide sequence ID" value="XM_004364490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5D3"/>
    <dbReference type="STRING" id="595528.A0A0D2U5D3"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5D3"/>
    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5D3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="224"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="541" mass="59908" checksum="6785377FE0DF1920" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5T3</accession>
    <name>A0A0D2U5T3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364669.1">
        <property type="nucleotide sequence ID" value="XM_004364612.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5T3"/>
    <dbReference type="InParanoid" id="A0A0D2U5T3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="403" mass="44336" checksum="0C43FED74605BDF4" modified="2015-04-29" version="1">MTDDAALQPQQATSSDPSVALQEQQRRPRAVLHKSTYQRGTPMFTSPVLPMLPASIAKVIQLDASVGTKQQLQQQPQQPQQQRQTATNSSERRFAALSDAELKDALDRQRALARSRSIMEALPAEKRAPILERLQLLERESAFRQSLDDVVTLMAGVELQPTVPTVPELSNPDHGAASMLPSDPNVQKGPPQPPREQPTQLSARAAEARSLTMPRVLDAHNEPDRSDQSVIVEGERQARLGRRAIAHAQAPGRPQVHALSLESSLAMLQHQHELQLQQELLQRQAAAKVQPVRAKAGALTLGASHDKMFAQRGSPSTITPVSGHASAARSLQTKASRPRNDAMYRDPDEDDDQDDDDDVDENDDEFDSDDDYPDDGGDDDDDDDIETYFHDVTRPSAFAGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7S5</accession>
    <name>A0A0D2U7S5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7S5"/>
    <dbReference type="eggNOG" id="ENOG502STD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7S5"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7S5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32403" checksum="5D1B5C70C82443E0" modified="2015-04-29" version="1">MAHSLLGAPDEVLRQCDNRCAHNVLLDQLWDLNLRVLLIIDELDEGYRHASDAPFRSTLAGLQALGNSTSGRVAVVLCGSSSSLPDLICGRRKDGFRDGWPNLNSTKFSLVRIPSPSPLDESLVASILSQTKLCPSTLVNQRHLLYLAGTNIRSLHVHLSDAKHPMPEVDLEQLEDGPHQYHKCARPLLTAILDKLIDKNKELLEELVDMKVLKAIPSQIQSVDWPSRFLPVDEIEIDALWKKLQDHLKVASDLQAPLPRTLRHLLDEGVLIEVEGDYFPYSLAGLLASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U829</accession>
    <name>A0A0D2U829_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349171.2">
        <property type="nucleotide sequence ID" value="XM_004349121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U829"/>
    <dbReference type="FunCoup" id="A0A0D2U829">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U829"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U829"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U829"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="405" mass="44532" checksum="C44E7D739CDA5107" modified="2015-04-29" version="1">MSSSTAQVAAPAWAQLPNLASDKVDTKILFTTDDFFAVAECMLSSKDPVFIPDAFTEFGKLMDGWETRRKRTLGHDWCIMQLGLSGIVKGIAVDTAFFTGNQVPRISVQAARLDTAPTLVRRSQGGTAATTEEIEAAERLGSVDWTEILPRRVLQPGYPETRQHYFDVSSNERWTHLRINLYPDGGIARLRVHGLVVRDWSQVSTTDVQDLVAVENGGRALYHSNSHYGRSSNLINPGRAADMGDGWETARRPDRPAIYTMGHDGHVVMPGSDFAVLKLGHVGVVDSLEIDTNHFKGNFPESCFVEACLMTDSSSGEDAGDALVIGDCERKNEFQRTGTLAANAPAMSVEWKTLLPRTKLRAHEQRVFTVADNTLVNPGAISHIRLNIYPDGGVSRVRALGRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8J9</accession>
    <name>A0A0D2U8J9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349297.2">
        <property type="nucleotide sequence ID" value="XM_004349247.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8J9"/>
    <dbReference type="STRING" id="595528.A0A0D2U8J9"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8J9"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8J9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="5">
        <location>
            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="757" mass="81066" checksum="2A3DB5D4EBD380E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8Y8</accession>
    <name>A0A0D2U8Y8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8Y8"/>
    <dbReference type="STRING" id="595528.A0A0D2U8Y8"/>
    <dbReference type="eggNOG" id="KOG2146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8Y8"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="37412" checksum="D3AEAEF2E079CFDC" modified="2015-04-29" version="1">MRRVCVRVCERVSWTEGTRCSIFVLFDGSLFVSPFARCSHPSLIFLVLQFPDPRKMQLNLTGFLEGNTPDFMLELWKLLLSAQSSPGGVPQQLIEQKKQEILQRKVEMQRLQEAIKAKALATAASTVEEKPTLDLSIRAPASGTSEPSRERQPSPSHRRRSASPRRHRSRSRSPKRRSQRSRSRSRSPKRRSRHSRSRSRSRSRSPKKRQSRRSRSRSRSRSPRRRSHVHDRARDRLVAAATDRALVHDRPLPDATVVTRSRGIRPVDHTVTALPRSRSRSPGHDRKRSSSSRKSESTETAPSTESEPVDATASAAATEETPAAAPMDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9B3</accession>
    <name>A0A0D2U9B3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349489.1">
        <property type="nucleotide sequence ID" value="XM_004349439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9B3"/>
    <dbReference type="InParanoid" id="A0A0D2U9B3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="536" mass="58145" checksum="92BDE701DD9C80FF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB17</accession>
    <name>A0A0D2UB17_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270292.1">
        <property type="nucleotide sequence ID" value="XM_011271990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB17"/>
    <dbReference type="STRING" id="595528.A0A0D2UB17"/>
    <dbReference type="eggNOG" id="ENOG502SE4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UB17"/>
    <dbReference type="PhylomeDB" id="A0A0D2UB17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="155"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="35607" checksum="E6EDAC0FCC0A259D" modified="2015-04-29" version="1">MSAFTRFTVDDLEDDDDRLAFPSAPNGPFQPQSQQPPPQPQQPQFQSGASRASPAQHPRTSKTTTSNSSSSSSARPQSHLSLVLGDEDDDDDAPWGAKRALEDSAPASRSSSRNAQPYWAETSLAAAATGSGLHSLRINRFTNAASALFYSKYYFIVYMIVVVLCLTSLIWSLTDSKEQVVGVIVIEVVINVILIFELFIRFMSLGAKAYFASWWNRFDLLVLLLCVGALITYIASTGGENQSEQVEDVVSLVLLVIRSVLQVIRVTLLLRSQYRQLSTRREVDILRVDRKRTDSMSNMLSTSDENLHANNYLLGDEDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBI5</accession>
    <name>A0A0D2UBI5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBI5"/>
    <dbReference type="STRING" id="595528.A0A0D2UBI5"/>
    <dbReference type="InParanoid" id="A0A0D2UBI5"/>
    <dbReference type="OrthoDB" id="5970620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBI5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019322">
        <property type="entry name" value="TIMM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10171">
        <property type="entry name" value="Tim29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18307" checksum="0FFE44ABEE98A507" modified="2015-04-29" version="1">MGSAVREKITVLYGDYKTATLDTIKAIRTRPHVAAGWAGLFGSLGYIVATNPAPQSYERAALVASGNELYLLSPAARNARTFATVQSARELAQQHQLYHLDLVLFSLILRKDTSADCKSYRHKIGQLEFSHPLSLSALNTKVVDVGAVGRWWRLERTMVDFDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBZ6</accession>
    <name>A0A0D2UBZ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBZ6"/>
    <dbReference type="FunCoup" id="A0A0D2UBZ6">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UBZ6"/>
    <dbReference type="InParanoid" id="A0A0D2UBZ6"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01800">
        <property type="entry name" value="Ubl_SF3a120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035563">
        <property type="entry name" value="SF3As1_ubi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="742" mass="81026" checksum="AC40AEA510F218C7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UD70</accession>
    <name>A0A0D2UD70_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UD70"/>
    <dbReference type="STRING" id="595528.A0A0D2UD70"/>
    <dbReference type="InParanoid" id="A0A0D2UD70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF1">
        <property type="entry name" value="OS04G0446401 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="886" mass="95269" checksum="94A9C35CAFC0D865" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDG3</accession>
    <name>A0A0D2UDG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363647.1">
        <property type="nucleotide sequence ID" value="XM_004363590.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDG3"/>
    <dbReference type="FunCoup" id="A0A0D2UDG3">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDG3"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDG3"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1 4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="156" mass="16495" checksum="76619BD32AE9848B" modified="2015-04-29" version="1">MADDDADFPSSTTNAGPAAAGATSSSSSSSAAAAAAANPNAAAGADDDNAGAAPSAPSPWTLRKPPTKDKVIVQFRAAGNAPLMRQKKFKITASEKFQTVIEFLRKQLKFKPTDPLFLYINQAFSPAPDEIVRNLYQCFEIKGQLDIQYATTPAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDV0</accession>
    <name>A0A0D2UDV0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MGAT4 conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347893.1">
        <property type="nucleotide sequence ID" value="XM_004347843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDV0"/>
    <dbReference type="STRING" id="595528.A0A0D2UDV0"/>
    <dbReference type="eggNOG" id="ENOG502QPQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDV0"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDV0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF33">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="59701" checksum="6171CE85955E0E47" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGT9</accession>
    <name>A0A0D2UGT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGT9"/>
    <dbReference type="InParanoid" id="A0A0D2UGT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="772" mass="83746" checksum="7C8B8549EDD13892" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHB8</accession>
    <name>A0A0D2UHB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346824.1">
        <property type="nucleotide sequence ID" value="XM_004346774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHB8"/>
    <dbReference type="FunCoup" id="A0A0D2UHB8">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHB8"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHB8"/>
    <dbReference type="OMA" id="YRRVMTN"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="235" mass="26497" checksum="4ECCD020374BFE31" modified="2015-04-29" version="1">MASSELFENYEFEFTNISASITKKLSSQIPNFTGEQRKAAIKAVEKEIVQADEIVQGMELELKNAPAQFRPRLQTKLKTYQNELARIKKELRGLTNSGNRDDLLGGGSGAGSPAGFGGRSAYQDVEAQSNDQRSRILDSHDRLNRTTGRLDNAQRVAAESEAIGQDILGELGTQRETIVRVRGRLHETDDNLTRSRRILNGMYYRIIQNRLIMYIIVLVLMGILGIVVYMRFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI36</accession>
    <name>A0A0D2UI36_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ndufa9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347048.1">
        <property type="nucleotide sequence ID" value="XM_004346998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI36"/>
    <dbReference type="STRING" id="595528.A0A0D2UI36"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI36"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI36"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="324" mass="34947" checksum="81F4DD9145890710" modified="2015-04-29" version="1">MLSSQGRLVAAKSSSVSSIAARALSTSIASASSSTPVKSAGVPLTRAGDDAVATHTLAKWSGGPVSRAGTGGRSSVSGVVATVFGSTGFIGRYLVNRLGRVGSQLILPYRGDEHAYRHLKPMGDLGQFSFPFYHLRDKDTVKRLVEHSNVVFNLVGQEFATRNFSLHDVHVTGAETIARACQEAGVGRLIHVSALNASTESRSPFLQSKALGEQAVLAAFPNATIIRPATLFGPEDRLFNRLSVPMRTPFGVPLQNYGETRKQPIYVVDVARALIRAMEERTTAGKTFELVGPKEYTTAQLLQYMCDMARRPMRAFHVPSEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJX3</accession>
    <name>A0A0D2UJX3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJX3"/>
    <dbReference type="InParanoid" id="A0A0D2UJX3"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJX3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="286" mass="31563" checksum="20D858AC431AC597" modified="2015-04-29" version="1">MAGASEAATRCLAWLQAVKAAPEGEKHNVAVAVALKLVYQDSVTLQGGEIYRPTGWTTRAIAARLAEQGYQCGHTTVHGWKTKHANSAEWIRSSPLDQVLQLVKESPSCGGQSIFTEDELEYCIRLLEGFARAGQCLNQKQAGAYLVKLSRLPRMSGAPRRQFAGSLPSHEWWNAFLRDARGRLAIRKGRTLELTRIAALQAETLDCLPGLLKQLFDEHPLLVEEPAREQAPDHDDDAPGRISQRARLDSPDQAVQAPPALVDLSHRPNHLGFVPAMFPSQHLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULD6</accession>
    <name>A0A0D2ULD6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YdbS-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345058.1">
        <property type="nucleotide sequence ID" value="XM_004345008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULD6"/>
    <dbReference type="eggNOG" id="ENOG502SVVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULD6"/>
    <dbReference type="OMA" id="MCCSATH"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULD6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="YdbS-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YdbS-like PH" evidence="1">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="169" mass="18218" checksum="275250A6888FC7DC" modified="2015-04-29" version="1">MGKFCPNCGKAADSGKFCGECGAAIDGGAASPSGSSAQAVAKVSVTTEAKVEGGDDIIWEGETWPKGCLSPMCCSATHWKISRKRIDITRGCCGSTMDTTDFRRVTDMNFSRSILQMCLNRGTITIFSSDATDPELKLTTWRMKALYPKLRDAWGKARIATSVDVPDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMB8</accession>
    <name>A0A0D2UMB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMB8"/>
    <dbReference type="InParanoid" id="A0A0D2UMB8"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="102832" checksum="49BCD2B36ECDA172" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMU0</accession>
    <name>A0A0D2UMU0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">STE/STE11 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UMU0"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMU0"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMU0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="5">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="885"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1861"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1596"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1721"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1820"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2183" mass="233044" checksum="393F8AE4E8027DC8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMZ2</accession>
    <name>A0A0D2UMZ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMZ2"/>
    <dbReference type="STRING" id="595528.A0A0D2UMZ2"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMZ2"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="292" mass="32128" checksum="1C9A558952F3271A" modified="2015-04-29" version="1">MLSQAFLFFGYFSNLLPSPMPIPPPPTFPSLQLVLDAEHGVLWMTLDRPKKYNAIDGPLYDNIVRALDYAAQTDGVNIVVLSGNGKYFSSGNDLASMNQQYAEAAENPDGPQAMLDASRNRFSKFAIRFITFPKILVLALNGPAVGIGATIIPHADFVYASADATIYTPFTDLGQSPEAVSSMTFPAIMGMARANEVLILGRTFNANECFQAGLFSAVFSPEEFRQKVQERVAKLADKPPGSLLDCKKLIREKLIPAYLDTNERECNLLSQRWASDECAEALIKFASRRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URZ1</accession>
    <name>A0A0D2URZ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URZ1"/>
    <dbReference type="FunCoup" id="A0A0D2URZ1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2URZ1"/>
    <dbReference type="InParanoid" id="A0A0D2URZ1"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="307" mass="32240" checksum="68442D1CCED25872" modified="2015-04-29" version="1">MHHIHTQTEFAVEMTCGACEKAVNEAMQQLKQTSPPGAVGSVQVDLAEQRVVVESSLPSSTLLQAIESTGRKTVLRGQGDSFGRNLGSAVSILERDGTQDVIGVVRFVQISENECVIEGTLDGLSKGEHGLHIHEYGDLSQGWKSAGGIYNPKQMPHGPPSKDGGARRKPGAIGNVASDAQGRATFTLSASQLNVWDIIGHALVVHERPDDFGLGNAPRSSENGNVGAGVGAGIIARSAGLLGNAKRVCACDGKTLWSDSNPGALLPNKRVHIDNNSPPPVARSVSEGKPAIERAMDVTHPFILSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTW2</accession>
    <name>A0A0D2UTW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346426">
        <property type="protein sequence ID" value="KJE98431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTW2"/>
    <dbReference type="STRING" id="595528.A0A0D2UTW2"/>
    <dbReference type="InParanoid" id="A0A0D2UTW2"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="171"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="605" mass="64999" checksum="8FEF2EF54D8BA2CF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF75</accession>
    <name>A0A0D2VF75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF75"/>
    <dbReference type="STRING" id="595528.A0A0D2VF75"/>
    <dbReference type="eggNOG" id="KOG1593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VF75"/>
    <dbReference type="OrthoDB" id="188713at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VF75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253527" evidence="9">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="396" mass="41116" checksum="5706795C5F532DC3" modified="2015-04-29" version="1">MRITVLIVMLGALAASAASASAAASGPAPATAAFDAASAYLASPAAHVPRPAAIPQPRDNEPNQFQASLPIVINTWPFTDATRAAWASITTPSTSAVDAVEIGCTVCEIEQCDGSVGYGGSPNEDGETTLDAMIMDGITHDVGSIGCIKRVKSAISVARKVMEHTTHTLLVGEDATRFAVSMGFKEESLTTNNSISIYQSWKAQNCQPNYRLDTLPDANTSCGPYKPAPNTSNRGSSRYHTSPRINPAVGPGNHDTVGMIVIDANGNVAGGTSTNGASHKVPGRVGDSPITGSGAYVDNNVGGAAATGDGDVMMRFLPSYQAVRNMEAGMTPTAAAEDALRRIAKFYPNYLGALVAVNKQGQFGGAAHGWNFSYSVRNSTMSDVTVFSVTPLDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFY9</accession>
    <name>A0A0D2VFY9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365164.1">
        <property type="nucleotide sequence ID" value="XM_004365107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFY9"/>
    <dbReference type="STRING" id="595528.A0A0D2VFY9"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFY9"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFY9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF19">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="562" mass="60031" checksum="881469839B8AC26E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGX4</accession>
    <name>A0A0D2VGX4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365541.2">
        <property type="nucleotide sequence ID" value="XM_004365484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGX4"/>
    <dbReference type="InParanoid" id="A0A0D2VGX4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="913"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122673" checksum="DF98E1CB5F1ACB80" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHJ0</accession>
    <name>A0A0D2VHJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="13">FTase-beta</shortName>
            <ecNumber evidence="2 13">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000892</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of FNTA and FNTB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 13"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365763.1">
        <property type="nucleotide sequence ID" value="XM_004365706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHJ0"/>
    <dbReference type="FunCoup" id="A0A0D2VHJ0">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VHJ0"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHJ0"/>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000007">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 13" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="70"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="438" mass="48017" checksum="6795BFBCC53E70A1" modified="2015-04-29" version="1">MAVSSTQTIEELLVVDDQHPTRTTAEQLAVESSIERLYADIRYAAEDAANVRLSEAERKAAQDRLAACELRRIQHVKYLKRGLFMPFPAGYVSLDASRPWLCYWSVHALALLGAELNVEQAEQVVQFLKRCRNPDGGFSGSPQQLSHLAPTYAAINTLVTIGTPSALGVIDRERLLSFLYSVKCSNSEHEGGFSMHVDGEVDVRGTYCAVSVASLCQLPTDKLFEGTAEWLLRCQTYEGGFGGVPGVEAHGGYAFCAFAALVMLKRATSCNLKSLLHWLVNRQMRFEGGFQGRTNKLVDGCYSFWQGGTFPSVAYALYANEPNEAIRQALEGGFMNEVALQEYALICCQDPNGGLLDKPGKPRDHYHSCYVLSGVSVAQHDFRDPRKSTVVVGGPENQVLATHPLHNVLVSSVIAASKFYGKTPVVDPHPPKAQKSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKE7</accession>
    <name>A0A0D2VKE7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radixin isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364665.2">
        <property type="nucleotide sequence ID" value="XM_004364608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKE7"/>
    <dbReference type="STRING" id="595528.A0A0D2VKE7"/>
    <dbReference type="eggNOG" id="KOG3529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKE7"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="141"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="440"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109660" checksum="33AF5E01552A00E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKI4</accession>
    <name>A0A0D2VKI4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKI4"/>
    <dbReference type="InParanoid" id="A0A0D2VKI4"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKI4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="56" mass="6107" checksum="2204F3B8E757646D" modified="2015-04-29" version="1">MCAKRGHLAAVKKIVEHGSPVLCTDNNGWTPRVAAEKVGHTDVSSFLTNEERCADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL30</accession>
    <name>A0A0D2VL30_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Origin recognition complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348798.1">
        <property type="nucleotide sequence ID" value="XM_004348748.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL30"/>
    <dbReference type="STRING" id="595528.A0A0D2VL30"/>
    <dbReference type="eggNOG" id="KOG4557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL30"/>
    <dbReference type="OMA" id="NDRTHHR"/>
    <dbReference type="OrthoDB" id="5552484at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VL30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11583">
        <property type="entry name" value="Orc6_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="8">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41734" checksum="FF7EB42E2E30E93A" modified="2015-04-29" version="1">MNTVTHIADRMGIESPRVRAKAAELVRLAAINAPSAPGFEVVCRPAVALDTACRMHKEPFDRKMAIKLSGTNAKTYTLVLNTIQGVLDVRHRIDLRDLAIQMNCTDLLPQLKEFANRYREALVEEQPVASANPSDLFETAMSKPAVLAAVFYAGCRVMKFRVSRRKIIHACDIGETEFRNVLAKVESVIGVGDTEKHGSSDEESTDTSGNPRGRKRRQSAQDEDDSGSDSDNGDNNNASSSRKASRLDVADSSAAAALQSSSSSKRGERMAAACEMPPRPGTVASLLVQDTTTKRTYWDKSPARLFKATRAPAEPVLDDLPEPELPNAAARPVQTAPSSVSVSKPAPVKSRRPDPTKDTTFTPSAKTNRDYLDWKAKILGGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM75</accession>
    <name>A0A0D2VM75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349152.1">
        <property type="nucleotide sequence ID" value="XM_004349102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM75"/>
    <dbReference type="InParanoid" id="A0A0D2VM75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="302" mass="32128" checksum="A2459D3F91378A16" modified="2015-04-29" version="1">MDPSELTERLPLTAAARQRKMQNAITASSTNAPQRRYSAVAVVQNATSELSFGANLVPDAVVVPLVKPRASRITKIEITLNASCAALAQAIGDASSSRVSLSTQPLRGCQSRSAFTAVHRSSQQHHASAIANAGLLKRTDSSNSSMLDARRGVDENGAGLPAGPSSEPKQPQAESALALSSACIGPRPPFEVLDKQYSTGQLKNSDAHLRSAKCDFPDELDSLLMDEDHPRLIVRNTVALVPSCVLPRVSPTRWSQSLNALDGRLPDSFDKPVHTFSGGNLRSTTVSSLVHESTVPDADTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNC8</accession>
    <name>A0A0D2VNC8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270256.1">
        <property type="nucleotide sequence ID" value="XM_011271954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNC8"/>
    <dbReference type="STRING" id="595528.A0A0D2VNC8"/>
    <dbReference type="InParanoid" id="A0A0D2VNC8"/>
    <dbReference type="OrthoDB" id="2411356at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNC8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34852" checksum="CD70AF39CCF0650B" modified="2015-04-29" version="1">MSVAAPAAGPAQQQPAFRRVFGFIGGAVANAVSTTFIILVVAAFVAQHVLDNKNTIAKTHSPEIVQARMLARFEAGSVIPRFEKYHVSRPDAVAMLQKVLRPALLKDYTVVIGEVGCGKTTAVLDAIRANSTGIVYHIVQSEVLVSMPGYFKDRGVEMHQIASAEEPFKSWAILELGLRDVAAQFKAKHGHVATLVIDAVDQIAQQGPALLHVIQNFAKAAADEQLLNVVLVTCDGSNLPELKASSAMTRARIVEVSDITDEQAVDFLLHRGVNEDAAKRAVAEIAGGRFVLLNSLVFELQFKTVDEIFEEFAWIRQTPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRI4</accession>
    <name>A0A0D2VRI4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette sub-family F member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348094.1">
        <property type="nucleotide sequence ID" value="XM_004348044.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRI4"/>
    <dbReference type="STRING" id="595528.A0A0D2VRI4"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRI4"/>
    <dbReference type="OMA" id="STFEEAH"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRI4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="211"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="568"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="818" mass="88885" checksum="80A51216618F57E9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRN2</accession>
    <name>A0A0D2VRN2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRN2"/>
    <dbReference type="STRING" id="595528.A0A0D2VRN2"/>
    <dbReference type="InParanoid" id="A0A0D2VRN2"/>
    <dbReference type="OrthoDB" id="2428500at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="406"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="511" mass="57256" checksum="DA231B6277A4BAB2" modified="2015-04-29" version="1">MSDSENSVPHASSSSPLKHRRHLTNQERETICKMIADLGRPPKQVANELGIPPSTVYAVYDAFRRRGDSDAIKSLPPNNSVLQDNHLAFLKHKLDDDVNLTNKQLNDHLEKEFGFRVHESTIGKAIKRAGYSFKRVYEQVKLKNSDRIKDQRKEFAETFMQHAPPIHRIFYVDESGFNANQHRLRGRAPKGQRAIKQVKTIRAPNFTLIAAIGMQGLVLKDVRMGGVKGTVFKDAMGKLFDHLEQEGFVDDEAVGVDPKDLPEQPIEPDVPPANMIEEDDAEDAASDIDADNDAESQEPAAQSSSSAAAAPASSSAAPTLATSASQLQAHHSHQVENVHDNQQGAAAARAPVRGRKRRHQDDDDDDDDEYYPTQAEFQQDQAEEGNDNSEYIVQSEEHPGVSFPQNKRYKAWIVLDNCRIHKTEQVREFFAERGYCMVFLPAYSSFLNPIEYVFNTVKADFKKHSLETGESVSQRIRQATAAVTPEGCQNTINHINLTYVTPCLQREEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT04</accession>
    <name>A0A0D2VT04_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346676.2">
        <property type="nucleotide sequence ID" value="XM_004346626.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT04"/>
    <dbReference type="FunCoup" id="A0A0D2VT04">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VT04"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT04"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="356" mass="40041" checksum="DB4FE05A6FDAA700" modified="2015-04-29" version="1">MQDSSDEEEEAPSDQKSVIFHLLKQLSIGMDLTKVTLPTFVLEKRSLLEMYADFMANPMAWLKVGDSNDPKERMMQCVFAYITSFHGFKKGTIAKKPYNPIIGETFECQYDLTAEGAGISTYFAEQVSHHPPVSAFYFENKQKGISIAADVWTQSKFLGTSVASLLVGQSTLTLHKRNEQYVMTYPNVYGRSILSVPKLELGGKTTIVCSQTGFTADVEFKTKPMFGGSYHELLCTVKEPNAKAPFVKISGKWNEVLVIQYTGAKEAPYFDAAKAIKVNKSVRALDVQAPFESRRLWKDVTENLRAGNIPAATAAKELLENRQRQEAAERKQANTEWKVKHFSKNDQGRWIYHHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTI4</accession>
    <name>A0A0D2VTI4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346881.1">
        <property type="nucleotide sequence ID" value="XM_004346831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTI4"/>
    <dbReference type="FunCoup" id="A0A0D2VTI4">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTI4"/>
    <dbReference type="eggNOG" id="KOG3797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTI4"/>
    <dbReference type="OMA" id="WSWLFFG"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTI4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="189" mass="20896" checksum="30AAB1787CAD97E6" modified="2015-04-29" version="1">MAEDFTTVFLRELQANPAAVLGAIVLPAAGGVYGSRITRANLKTWYAKLNKPWFNPPNYLFPPVWMILYTLSGFASYLIWKEDHIWPLVPYAISIITNNLWTPLFFGFHLLNLALLDLLVLWVSLASCIALFHPINELAAMLLLPYIAWVSFAGVLNFSILLKNPSTKPSSAAAAATTSDAGASQKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV23</accession>
    <name>A0A0D2VV23_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV23"/>
    <dbReference type="InParanoid" id="A0A0D2VV23"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="442" mass="48261" checksum="DF9CE726244C9592" modified="2015-04-29" version="1">MAAAIVAACIPALVAVAFAVVVEIILPQRREARRHHTPLNPVTVSNASPNGPFNSAGFALKLDAHCRPAACHSEFHRTAATATTNDSGFQPVLMLVPFTSLNVLRAVYRTHYNTTTLPDQAVQATWWLNATAPASEEVWRPTLLTFSEPLVFLTNAVAALLVISIFTVDIAAVGSTLTQLHLKKSIASWEHHVGYTVSVGLGFARYGSATGDLHIGSDDCSALLDTVLLLLASPKSMLAGVLAALSLALILPERLMFSPAPRSLTFVKFAHHPWSMVRALLSASWYYGKAPATFLPPDTAASAFWDALPCFSCALGVLSLFLSSCTFVEDAFDRWVTILDWRPVHFESLPPLLAALLLVPWHLVFSLRAFWCARWARGSTPSIEAMFQAETQAESEFLRNEASRDHPSDASIKMTRRRSGGNMRLVWVSFALRFGFTNRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVT4</accession>
    <name>A0A0D2VVT4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VVT4"/>
    <dbReference type="InParanoid" id="A0A0D2VVT4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1475" mass="144950" checksum="506A4E751F96BB59" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWQ8</accession>
    <name>A0A0D2VWQ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345140.2">
        <property type="nucleotide sequence ID" value="XM_004345090.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWQ8"/>
    <dbReference type="InParanoid" id="A0A0D2VWQ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="677" mass="72666" checksum="5B74CAF85E4DB6B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX20</accession>
    <name>A0A0D2VX20_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nox1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345248.1">
        <property type="nucleotide sequence ID" value="XM_004345198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX20"/>
    <dbReference type="FunCoup" id="A0A0D2VX20">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX20"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX20"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="543" mass="61457" checksum="5A46B2EB8000616D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX63</accession>
    <name>A0A0D2VX63_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345304.1">
        <property type="nucleotide sequence ID" value="XM_004345254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX63"/>
    <dbReference type="FunCoup" id="A0A0D2VX63">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX63"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX63"/>
    <dbReference type="OMA" id="LMCATEP"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="35286" checksum="D87D926DC153CC69" modified="2015-04-29" version="1">MSDTFNPAIPTTSNDGKSIGRFGYRTPAEEVVTELGIDLSDRVAIITGASSGLGQETARVLALKGARIILAIRNLEAGQKVAQEIQQSTGNTKIEAMLVDLTSLKSIKEFADTFLAKRLPLNLLINNAGVMANPTRETTADGFEMQFGTNHLGHFYLTQLLTPALIAAAPSRVVAVSSLGHTFSPVVFDDINWEKSYDRWLAYGHSKTANALFALELNKRLSPKGVIAVSLHPGGAATNLSRHIPRDYAISQGWMNEDGTMNSVFKTVEQCSSTTVYCAIAPEVLEHGGAYFEDCNLGVPVPHASDPEAAAKLWEVSEKLISNALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX96</accession>
    <name>A0A0D2VX96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Huntingtin interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344222.1">
        <property type="nucleotide sequence ID" value="XM_004344172.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX96"/>
    <dbReference type="FunCoup" id="A0A0D2VX96">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX96"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX96"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="8178130at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17006">
        <property type="entry name" value="ANTH_N_HIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000006">
        <property type="entry name" value="Huntingtin interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="623"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="302"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="827"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="96465" checksum="3672DBC563A23BFB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0V3</accession>
    <name>A0A0D2W0V3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343049.1">
        <property type="nucleotide sequence ID" value="XM_004342999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0V3"/>
    <dbReference type="InParanoid" id="A0A0D2W0V3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="620" mass="67134" checksum="F47C766B94571742" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W163</accession>
    <name>A0A0D2W163_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342662.1">
        <property type="nucleotide sequence ID" value="XM_004342613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W163"/>
    <dbReference type="FunCoup" id="A0A0D2W163">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W163"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W163"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W163"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="187"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="796"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110573" checksum="8B4D83AD8B35367F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1D3</accession>
    <name>A0A0D2W1D3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342714.1">
        <property type="nucleotide sequence ID" value="XM_004342665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1D3"/>
    <dbReference type="STRING" id="595528.A0A0D2W1D3"/>
    <dbReference type="eggNOG" id="ENOG502RZJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1D3"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1D3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27207" checksum="4343BFBC49221159" modified="2015-04-29" version="1">MATLSSLPEYAIACSKSREIVEHRPDYVAQIRNEVPKYIYRRHPGLLERLSALLDATVIFAQDHAGTGVCVSKDGLILTCAHCLDDETIGARRIVLFPDGRKCVVECVAKDDVRDCALMRVVQVDRKVVRASDNISFPFASLASQGALPCSLAFCIGQPASDDEASNYPLFFTSRGVILGYQSSGEDLHRNDEIGQLIHSCWTYWGHSGAPIVNEDGLIVGMHSSWDDKTNRHGIPLEAIRAFMKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHE3</accession>
    <name>A0A0D2WHE3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365460.2">
        <property type="nucleotide sequence ID" value="XM_004365403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHE3"/>
    <dbReference type="FunCoup" id="A0A0D2WHE3">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHE3"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHE3"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHE3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000034">
        <property type="entry name" value="Chaperone protein DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="561" mass="58269" checksum="891C9EC03DB0F39F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIU4</accession>
    <name>A0A0D2WIU4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349785.2">
        <property type="nucleotide sequence ID" value="XM_004349735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIU4"/>
    <dbReference type="STRING" id="595528.A0A0D2WIU4"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIU4"/>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIU4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254993" description="LRRNT domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="834" mass="83758" checksum="DD437DABBE9A5A2D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ34</accession>
    <name>A0A0D2WJ34_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349904.1">
        <property type="nucleotide sequence ID" value="XM_004349854.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ34"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ34"/>
    <dbReference type="eggNOG" id="KOG4627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ34"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ34"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="36107" checksum="D07188ACA67B7695" modified="2015-04-29" version="1">MTDTNRAVYRTFNIKELDFQYSPSQWSIRGSPDEVINKHVAWLVNGSDRARKVLAESAQLNVRYSTLEAKVAGGGGGGGAAAIPADSSETALDLFFPPEAKTPEQRAKCPLVIYIHGGYWQFLNKDASSFMAENFCKHGLAVAAIGYTLAPAANIFEIIHHTRLGVALAHQLCPGTTAHLIGHSAGGHLAAMCIATSAEEWQAKYGVPAGWIRSATLVSGVFDLRPITMVPSVNDAVRLTMADAQVASPLLLLASIPHDIHVIVAVGRHDPEEFRRQSREFHDNLVQHRGNITDKTQFVYCPEDDHFEAIEKLSHADFCVTQAVFAVARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKD1</accession>
    <name>A0A0D2WKD1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349929.1">
        <property type="nucleotide sequence ID" value="XM_004349879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKD1"/>
    <dbReference type="STRING" id="595528.A0A0D2WKD1"/>
    <dbReference type="eggNOG" id="ENOG502SDMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKD1"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKD1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266422" description="Right handed beta helix domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="87568" checksum="715AEF2E2D2FD315" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKI0</accession>
    <name>A0A0D2WKI0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348783.1">
        <property type="nucleotide sequence ID" value="XM_004348733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKI0"/>
    <dbReference type="STRING" id="595528.A0A0D2WKI0"/>
    <dbReference type="eggNOG" id="KOG4462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKI0"/>
    <dbReference type="OMA" id="GYHHGRR"/>
    <dbReference type="OrthoDB" id="6157464at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="442" mass="41714" checksum="45E92EA643A672B1" modified="2015-04-29" version="1">MPPPPPPPPGPPPPPAAGPPPMTKGGEKARGALLGDIRGGTKLKKTVTNDRSGPVLDAPKGGGGGGGGGGGGGGGGGGGLFAGGIPKLPNKGGGGGAGAAAAPGPRPPGMAMPRPPTSSPSSAGGAPRPAPPSMNSGPRPPAMGGAPRPPMAPTPAAAAPAPRPPAPMATPTSSAGSPGMARAPPPSAPRPGGAPPPPSRAGPPPAAPSPVSSAPRPAGPPPPSRGGAPPPPGRAGPPPPPARDDADSSSASNSPRSSAIGAPPPPNRAAAPPPPTRSAAPAPPPGRAGPPPPPGRAGPPPPPTRDAAPPPPPTRDAAPAPPPAAQRAGPPPPPGRTAGPPPPPSNRTSAAPPPPTRASNAPPAPARSNQGGDFESRFFPNPPSIPDPEPYTPGPKTYISATSGPAGARTSTAARAAPAAPNRGSAPPPPPNRSSPRPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKJ5</accession>
    <name>A0A0D2WKJ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="8">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKJ5"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKJ5"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKJ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 8" id="KW-0041">Annexin</keyword>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1399" mass="155971" checksum="649F3FFE12696453" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL05</accession>
    <name>A0A0D2WL05_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL05"/>
    <dbReference type="STRING" id="595528.A0A0D2WL05"/>
    <dbReference type="eggNOG" id="ENOG502QR0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL05"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL05"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="406" mass="43593" checksum="1D5578F3BFD366A2" modified="2015-04-29" version="1">MVDAGVRHRPHTASTTTSTASKISLSSQQHSGCTLVRQQQREGLLLALVLNGAAQVTSAEPTVADAASNSTSDKNAAIGFGAVTASVFLWGSNFVPLKRFESGDGLFFQWVLCSFIFMTGIVVNLIQGSPEFHPFAMIGGLLWTTGNITVVPIVQLLGLAQGMLLWSSSNLLMGYFSGRYGWFGVTPAPPNDAALSSAGVALCCISLVFYLFVRPTLDNAKSQNSAGYLPDYLQHRSLSGATGSWVDKLAPAQRTWVGRSLALFAGCCYGLNFTPVAYVQDNYEGASQSGLDYVFAHFTGIYATSTCYFVLYCIAKKNQPMIYPKLVLPSMISGIMWAISQSMWFVANQNLSQTISFPIISTGPGVVSSVIGIVIFHEISGKRNFIFLAFAFAFAFGGVIMTALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL74</accession>
    <name>A0A0D2WL74_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tat-binding protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364706.2">
        <property type="nucleotide sequence ID" value="XM_004364649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL74"/>
    <dbReference type="FunCoup" id="A0A0D2WL74">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL74"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL74"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="47473" checksum="210483729C04C624" modified="2015-04-29" version="1">MSLAMDTTPAAAAPSLKSKRPAAKSAASSEPAAAAAVAEAGIRQYFTSKIQELQLTVQTKTQNLRRLQAQRNELNSKVRLLREELQLLLEPGSYVGEVVKIMGKTKVLVKVHPDGKYVVDLDKGVEMSQLTPNLRVALRNDTYAIHKILPNKIDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPFKHPELFDSLGIDQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRSEGGSGSGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPAPSELARTDILKIHSRKMNLTRGIDLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVSKVMQKDSERNMSLKKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN45</accession>
    <name>A0A0D2WN45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270246.1">
        <property type="nucleotide sequence ID" value="XM_011271944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN45"/>
    <dbReference type="STRING" id="595528.A0A0D2WN45"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN45"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN45"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="32099" checksum="82538810D77545BD" modified="2015-04-29" version="1">MSIRVLSPPSPTTAGVSLQTVELSAGESTATVNLLGATLVSWTHRGTELLFVSKKAVYDNKKAIRGGIPVVFPQFGAWDNGRPQHGFARSTAFAYKDKDSVAQRGSDGNDSAMAVFELSDSEATRAMWNHPFRLVYTVTLTPKSLEQHLVVHNTGTEEFSFTTLLHTYFRTDSLKTVTVAGLTDRDFKDKVDNMATKHEDRDVVTVSELTDRIYMKTLDEHLILNLAGGKGVQLVKENMPDTVVWNPAEEGGKAIADLGGEEVNHFICVEAGAVVEPVTVAANSSKSFRQTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNT5</accession>
    <name>A0A0D2WNT5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 2-alpha kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Hemin-sensitive initiation factor 2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_003792</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer. Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNT5"/>
    <dbReference type="FunCoup" id="A0A0D2WNT5">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNT5"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNT5"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054521">
        <property type="entry name" value="HRI2_3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="415"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="658"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="725"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="905"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1145"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE92910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1176" mass="125195" checksum="810102FC3B7250DC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNU4</accession>
    <name>A0A0D2WNU4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gnl3l protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNU4"/>
    <dbReference type="FunCoup" id="A0A0D2WNU4">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNU4"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNU4"/>
    <dbReference type="OMA" id="KLCPARM"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNU4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="168"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="676" mass="74897" checksum="F20376EB10F6CD06" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPE9</accession>
    <name>A0A0D2WPE9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vitamin K epoxide reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPE9"/>
    <dbReference type="InParanoid" id="A0A0D2WPE9"/>
    <dbReference type="OrthoDB" id="2093442at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270087" description="Vitamin K epoxide reductase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10415" checksum="E06FE82AD31CA9FD" modified="2015-04-29" version="1">MFCIQLLLPVVFLSHIDSLTPTRVLLAGCVLLELLLSYRPCIMCTLCFLIAMAMAITVGFSSYSSAPSDKMVVHLGWRGQLDAMKGHLNVSLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPH8</accession>
    <name>A0A0D2WPH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA pseudouridylate synthase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348412.1">
        <property type="nucleotide sequence ID" value="XM_004348362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPH8"/>
    <dbReference type="FunCoup" id="A0A0D2WPH8">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPH8"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPH8"/>
    <dbReference type="OMA" id="EYTTKMP"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="7">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="6">
        <location>
            <begin position="195"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="515" mass="56302" checksum="1599E7B89C675BD6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQS2</accession>
    <name>A0A0D2WQS2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348006.1">
        <property type="nucleotide sequence ID" value="XM_004347956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQS2"/>
    <dbReference type="STRING" id="595528.A0A0D2WQS2"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQS2"/>
    <dbReference type="OMA" id="KGWASRA"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQS2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="98250" checksum="95B075005012A261" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS51</accession>
    <name>A0A0D2WS51_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS51"/>
    <dbReference type="STRING" id="595528.A0A0D2WS51"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS51"/>
    <dbReference type="OMA" id="NQHARAT"/>
    <dbReference type="OrthoDB" id="206587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF86">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="291"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="638" mass="70491" checksum="29B4CBB42FD89EDF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT21</accession>
    <name>A0A0D2WT21_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT21"/>
    <dbReference type="InParanoid" id="A0A0D2WT21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="30319" checksum="F38F73C0448BC5DC" modified="2015-04-29" version="1">MAHNNKHNNKTNNNTNKQHKQTNKRTTTGARQRTTRHHQLELHLCAFRRVPDNSQKHVHPHVWRARETKVRAVLLGMGVGARESHGCSIEQRNAGALEGLGDDNVLITLLGGELEGVVAGILDGLGAAAFAAAVPVTAGVVARRGGSPNQQGRAVVVVAELDHLLRANRHEALKRFPEGLVGHVPRRRVNPQANVGEENVHQAEHLGDLGLQRVVVDDRQGLLASKVEQVGREGERDGEVDLRVVGRVRASIFIRGLCHVESSRVDRQGQGIVGLTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUV1</accession>
    <name>A0A0D2WUV1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344431.1">
        <property type="nucleotide sequence ID" value="XM_004344381.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUV1"/>
    <dbReference type="FunCoup" id="A0A0D2WUV1">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUV1"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUV1"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="63" mass="7410" checksum="9CB6A71011B1EE8F" modified="2015-04-29" version="1">MYLMYYEENGKRQYTMKKTAPDGTPTKSAHPARFSPDDKYSRHRVTLKKRFGILMTQQPEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV95</accession>
    <name>A0A0D2WV95_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345176.1">
        <property type="nucleotide sequence ID" value="XM_004345126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV95"/>
    <dbReference type="STRING" id="595528.A0A0D2WV95"/>
    <dbReference type="eggNOG" id="KOG1476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV95"/>
    <dbReference type="OMA" id="HTAWEPT"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV95"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="13">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="390" mass="42271" checksum="E9E07528FFA71FA9" modified="2015-04-29" version="1">MPPRLAPYVLTALASCIITTQVCFVLLSPDPRLRSDCALVHSAAPLGAGTGPAPEAGLPPTRLLPAQRLPMQNRGNAILANGPQQSADTAACACTPNSTLADWNQAAPAYAPLRPEGLPVIYVITPSKPGPTQKADLTRLASTLRQVPALHWIVIEDQPAPTALVAALLERSGMRNSYSHLAVQSEAVSAGPRYKTARGVEQRNLGIAHLRELVSAAAAAAAQLKRSPQRPGDQQGESETSAPEGVVYFADDDNTYDLRVFEEMRFTQHVSVWPVGIVGGLMYEGPVVDLATRRVVRWHVGWKKQRQFPIDMAGFAIHARNFINTPGELLSRSSPRGYLESHLLARFVRQLAQLEPKADLCSTILVWHTRTEAPDLSQEEAHPSDPLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVP8</accession>
    <name>A0A0D2WVP8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVP8"/>
    <dbReference type="STRING" id="595528.A0A0D2WVP8"/>
    <dbReference type="eggNOG" id="KOG4495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVP8"/>
    <dbReference type="OMA" id="IHCDPTE"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725">
        <property type="entry name" value="OS03G0364000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="97" mass="11068" checksum="B673B38B25FC58BB" modified="2015-04-29" version="1">MYIRIKRKKLTVFLECSLSDTVGVLKQKLGRIVQMEPANMRLLFDQQVLDDSKTVELNRLANDDQVVLVYKQADGEWEAPDVTPTDTANLDAKLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW28</accession>
    <name>A0A0D2WW28_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ufm1-specific protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343449.1">
        <property type="nucleotide sequence ID" value="XM_004343399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW28"/>
    <dbReference type="STRING" id="595528.A0A0D2WW28"/>
    <dbReference type="eggNOG" id="KOG2433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW28"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000001">
        <property type="entry name" value="Probable Ufm1-specific protease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049387">
        <property type="entry name" value="UFSP2-like_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20908">
        <property type="entry name" value="UfSP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UFSP2 second" evidence="7">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="6">
        <location>
            <begin position="424"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="615" mass="66966" checksum="32792B1E96C21BC1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWB6</accession>
    <name>A0A0D2WWB6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343571.1">
        <property type="nucleotide sequence ID" value="XM_004343521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWB6"/>
    <dbReference type="STRING" id="595528.A0A0D2WWB6"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWB6"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWB6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="306" mass="32741" checksum="3BE19AAB1BE7D9D9" modified="2015-04-29" version="1">MSLAPRGLALGFLPTRAAFAIATGSSSALACSITRSSGMAPWTSAVAMLRLSSANGLSTTAANAANAAANPLRTASMHGTNAVRASMSRVWSAERVPPSFVSATLLHTATASSLRPTACTTAASSLMQFRHYSSGRPGFMRSSEHWRDRLARYAKTSFYGIIVLAGAGAAGYMLWNVASEMFSEESVGRMYADALDRVRENAVIAKVVGPTISGLEEGRGQPRMGVQQFDFEGVTHTRLNFPIKGEKGEATVSAEMHSAHGEYMYRYLYVETPAPPGKNKKANVYVIIQPPPEKKPAPQAKKGWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWI1</accession>
    <name>A0A0D2WWI1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWI1"/>
    <dbReference type="FunCoup" id="A0A0D2WWI1">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWI1"/>
    <dbReference type="InParanoid" id="A0A0D2WWI1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270233" evidence="8">
        <location>
            <begin position="26"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="449"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="685" mass="75104" checksum="1E2182DA358ED040" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWK8</accession>
    <name>A0A0D2WWK8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343894.2">
        <property type="nucleotide sequence ID" value="XM_004343844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWK8"/>
    <dbReference type="STRING" id="595528.A0A0D2WWK8"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWK8"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWK8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="295"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="630" mass="67521" checksum="666CDF4C30539031" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYZ0</accession>
    <name>A0A0D2WYZ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346400">
        <property type="protein sequence ID" value="KJE98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYZ0"/>
    <dbReference type="InParanoid" id="A0A0D2WYZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="96" mass="11062" checksum="F2C9DD8CE4B93013" modified="2015-04-29" version="1">MCCTRICFGCKCRFHQPGFVCFGCNCGFESFNQRRISRFFCRESRLDQSGFGCNRRFHELGFGLGCIFCRSSRFHQSGFGCVRRFHEPGIGGIFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ10</accession>
    <name>A0A0D2WZ10_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_010235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="KE346418">
        <property type="protein sequence ID" value="KJE98413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ10"/>
    <dbReference type="InParanoid" id="A0A0D2WZ10"/>
    <dbReference type="PhylomeDB" id="A0A0D2WZ10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="583"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="934" mass="106622" checksum="BD8607BF13ACE720" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X086</accession>
    <name>A0A0D2X086_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_000250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365121.2">
        <property type="nucleotide sequence ID" value="XM_004365064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X086"/>
    <dbReference type="FunCoup" id="A0A0D2X086">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X086"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X086"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X086"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="226"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE88624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="494" mass="55868" checksum="50C4C2939E5319A7" modified="2015-04-29" version="1">MSEATQQRILDDLHAGTVIADTEQYAANIQADHQTVVGAMKSLERYPEMITTKPFDKTLVSLTEEGLVTVKEGTLDARIFNGIDKTNGTTLAELTARFGPATGQAQGRAMKNKWIRLDKASGKLFRAVETIVDEAQQQLAAIQAGQTVPDSALAELRKLKLAASRTYTAYAIGKGDKFSTKIVKPESDLTTAMLTKDAWREVTFKDKNLKALGAPTSGGYLHPLLKVRTQFRNIFLEMGFSEMPTNNFVESSFWNFDALFQPQQHPARDSHDTFFIKDPSTSTQFPEDYLKRVHEIHEKGGYGSIGYRYDWSRAEAQKNILRTHTTAVSTRMLYQLAQQKEFKPVKYFSIDRVFRNEALDATHLAEFHQIEGLVADRNLTLGDLIGLLSQFFKKMGIEKLRFKPAFNPYTEPSMEVYSYHEGLKKWVELGNSGIFRPEMLRPMGLPEDVSVIAWGLSLERPTMIKYKIDNIRALVGHKVDFNVIRSNPICRLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F6</accession>
    <name>A0A0D2X0F6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F6"/>
    <dbReference type="STRING" id="595528.A0A0D2X0F6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0F6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="504" mass="54138" checksum="768D940C7EC74075" modified="2015-04-29" version="1">MPAPADSDDTFVRVPSNRDCEEDGARLLRLAFEGQTFLGTNDDAGGASLGASKLPFASNGETDVKRGGMVLAPHQLRHKYGRGSPVRALDVTSGSLAAAARNAAGQTGTFLTGGAVAKLSQNAAAKLELRRLKNTCSFPDCGKVFSSRWALQRHQSCHNGLKPFECPVQGCHRAFGTKDGIRRHRMVHSDEKPHGCPYAGCPKRFKYVKTMRIHVKSVHTGERAHGCSICGKRFVTHSNLKDHLKRHQQRPDDGLDEDGKPRPGQPLRRGRVRGIGAKLGRRTFARAEPVGVNRPFSMLPFRSLLADHASRSTSDAMAATSTSAANSSSASQLPPLSSQSTLHSALELGGMMRHNTSQPFPSSMSSSLPPLALPRRQSVPAIKIDGSGSTLGPGTLPAIKLDGSSGLGPVTFSPTAANVLLRSAGLGQSNLPLLNMKQHRSQQQPGQAISDAHSTQQQQQQQQQQHQHQHSAEAQRQHLELLKLERQYGTGLVLATNVGLDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K4</accession>
    <name>A0A0D2X0K4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC-type glycine betaine transport system substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K4"/>
    <dbReference type="InParanoid" id="A0A0D2X0K4"/>
    <dbReference type="OrthoDB" id="2145805at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0K4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266716" description="ABC-type glycine betaine transport system substrate-binding domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-type glycine betaine transport system substrate-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="37805" checksum="733AD4A4A61CB54F" modified="2015-04-29" version="1">MRFQSVLSACVALLLIVPSAVSVCFPDSERRVLRTDLEPIRLGQGDWNGARVNNLVAKILLEEKLGIPASIIDIGSDDTVVFEMMDRGDLDAYMELWAMEDVLAHYVARGSVQYVGPLGVIGRYGWYIPDYVAELSRSMTQYDAYYFAETVAIFQLPVINSSTTSVSDSTSPLTVAESVEDLLASDTCNPANSSATLQACYDALAILVDQVRELSRLQENNTNLITFWTAPPSWSPIDATIVRNLELPMNVTEIPMLPEDNGDVEAAMVRNMAVAYAARKPFMMQFYVPHPVFSPLSGIGLKRVQLPDYSEDCNAREWPVLNALLSLTACVQCSVVGLVLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0P1</accession>
    <name>A0A0D2X0P1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0P1"/>
    <dbReference type="InParanoid" id="A0A0D2X0P1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="291" mass="30939" checksum="EC0884962578B940" modified="2015-04-29" version="1">MAVSRWRARRNPKAKATSAWTCLAVSKTWAGVSWIGKFVPSSWRGSKYPGGWSITYTQPSVLNVEVVRYSIQDWRVNSAGHMGRTQRRNKSAICAASSGEEKCSPSHGWLGGMSTALTGSRTLLEPTVDDEATGVLPIWHGRQTSAMVSLSCVRAASSSYARAGAALSARLLPIGLSARNMFALSASAKERLTEARVEVNGESERLLGPDLPFDDAAATAVKTAMPWPSRMPFVASLAESHSKHFVISETTLPDGDPGPSWPAAAALHSSNCFVFITGRGTGTAIASSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X107</accession>
    <name>A0A0D2X107_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_001369</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="6"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349889.1">
        <property type="nucleotide sequence ID" value="XM_004349839.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X107"/>
    <dbReference type="FunCoup" id="A0A0D2X107">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X107"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X107"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X107"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="126"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="508" mass="56403" checksum="FC544DDE49017904" modified="2015-04-29" version="1">MVKGDETKSKRPAPAAEQEEFEETPLRTAIWTYLGYAILILFGHFRDFLRDWGIEKTKFKRETGMQGFVPLFADFEAFYTRNLYMRIRDCWNRPISSVPGSHFDVLERATDDYNWNFRMTGRKIPLLNLGSYNYLGFAQNEGPCADAAAQAIREYGVASASSRTELGTSELHVKLEKLVAEFLGKEDAVVVGMGFATNSTIIPILCGKGSLVISDELNHASLVLGCRLSGASIQVFKHNDIEALERLLKRAVVEGQPRTHRPWKKIVIVVEGIYSMEGSIFRLPELIALKKKYKAYLWLDEAHSVGALGAHGRGVTEFHNVDPADVDIMMGTFTKSFGSAGGYCAGSKEIINHMRTHAHSSFHATSMSAPVAQQIISSMTVIMGRDGTDDGQRRIAQLADNARFFRTELKKMGFIVYGNDASPIVPLMIFQASKIAAFSRECLKRGVGIVVVGFPATPIITSRARFCLSASHTREDLEKALAVISEVGNLLGMKVSQKTPSRDYVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X109</accession>
    <name>A0A0D2X109_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X109"/>
    <dbReference type="FunCoup" id="A0A0D2X109">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X109"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X109"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X109"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="15"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="651" mass="73558" checksum="26D029F9889FFEC1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1D4</accession>
    <name>A0A0D2X1D4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364767.1">
        <property type="nucleotide sequence ID" value="XM_004364710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1D4"/>
    <dbReference type="FunCoup" id="A0A0D2X1D4">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1D4"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1D4"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1D4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="151"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="250"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="352" mass="37646" checksum="0B9B28864D8F22BD" modified="2015-04-29" version="1">MASSASAAAAPASAVSTAAIVTATSSSPSSSSSSPSASSSGAAGTWDETIKTGKFLIAGGVAGAVSRTCVSPLERLKILFQIKLTPTAAQEQAPTVWRSLVHIFKTEGLMGYFKGNGTNVIRMIPYSAVQFAAYEQYKKLLLTYPSPVDDLNTPRRLFAGAMAGITSVCATYPLDLIRTRLSAQGEGPDRKYKGIYDCLRTILREEGGARGLFRGLSPTLMGVAPYVALNFTVYESIKRWLLDQMQVKELSVPVRLLCGALAGATAQSITYPFDVIRRRMQMKGCSGPSFAYTSTLNAFTTIIRVEGVRGLYKGMVPNCLKVAPSMSISFVMYEFCKKLLFGGEVQGGRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1K0</accession>
    <name>A0A0D2X1K0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348918.1">
        <property type="nucleotide sequence ID" value="XM_004348868.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1K0"/>
    <dbReference type="InParanoid" id="A0A0D2X1K0"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="275" mass="29055" checksum="E414088DB82E6226" modified="2015-04-29" version="1">MSAHHTIVSLLDDDPLTRAMKQQQQQQSAKKERSSLTEAQLAQPRALAAAIAGSERAAAAAAAAASASASASSSGAPTDARMAMDIAIRKSEESLTHLVSRGDTLQGISIKYGISIENLKRSNNLWNQNALMIKKSVAIPIKFCTPEALIELGWQPGTSLAALAAASTNASGASTSGQSNGSVSANQLLQKYDSQLAQSKAFVSKLDSAFPEPPPALAVARSTAVPRSGSAPTTPQPRERHFILPENTERPASFDKGKRKLNENEHILDDDLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y7</accession>
    <name>A0A0D2X1Y7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VCBS repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y7"/>
    <dbReference type="eggNOG" id="ENOG502RZVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Y7"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Y7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836:SF1">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255432" description="VCBS repeat-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56405" checksum="36A554B549DCAC18" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X234</accession>
    <name>A0A0D2X234_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363772.1">
        <property type="nucleotide sequence ID" value="XM_004363715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X234"/>
    <dbReference type="FunCoup" id="A0A0D2X234">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X234"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X234"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X234"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="251"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="476" mass="52382" checksum="83A2529120CD3A5B" modified="2015-04-29" version="1">MANVNINRAVNDAFYRYKMPRLQSKIEGKGNGIKTVIVNMSDVAKCLARPPEYTCKYFGCELGAQTQMDDKISRYVVNGAHDAEKLQTLLDGFISRFVLCKSCQNPETELLLDKAQQIWQKCAACGAKNMVDMRHKLTTFILKNPPSSGALATTKNEHESQREASKALDGSAAPSPSKKSSKHDKADKGDKAEKGEKSDKKHKHKHKEEEDEDDGDWSVDTSADAVAARRHELNATLGESVSKLTHSEELELPEKKRINIFFNFASSSTCAAKPAAGAVARTANQIQAEAERLEIKEKAAGVLVEVCFNEAILQQIPKCSQFFVKLTDENKRAQRYVLGALEALIELYRATLLPKTSHILKAMYDNDILDEAEIIRWNDKPSTKYVSEEVSKEIHKAAATFVTWLKTADEEDDDDEDDEEEGDDDDEDESEEETPAKSNGKAPASSSSSASSSSKAPAAPAPAAAAAEDDFDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X288</accession>
    <name>A0A0D2X288_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X288"/>
    <dbReference type="InParanoid" id="A0A0D2X288"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="736" mass="80670" checksum="CEB37CE8599F52F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2U9</accession>
    <name>A0A0D2X2U9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347839.1">
        <property type="nucleotide sequence ID" value="XM_004347789.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2U9"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2U9"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2U9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="337" mass="37274" checksum="A472D2EB67CAB3DA" modified="2015-04-29" version="1">MPFTPAKVVYQPDDDFFADGNLMCYGESQQEIGQGESSNSVTTTSAFVDATAISIANPVVATHRPVPVQDLVEQLLSNGHTADDDDDDDDDDDDNRQIDADPRVDTAHASSLQCQVPGCSYLAPNIGLYESHYAAIHRHSCRVCGRVLPTDRLLSLHLLELHDSMFAVMAERQPMFECLVEGCGIKFINPDERHVHLVEIHRYPATFDFSVARRGKRKPHQQQQQQPSAESPSDASARSRIPTSIVFGRGGRMFSASAMKAANSRSEQRETSKKSNASRDSKHDVRRQLMTPASDASATELPKLNRRARRELARLQEQQQTAQEAVASDASPTDMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X312</accession>
    <name>A0A0D2X312_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X312"/>
    <dbReference type="InParanoid" id="A0A0D2X312"/>
    <dbReference type="PhylomeDB" id="A0A0D2X312"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266766" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1277" mass="139564" checksum="183F36CFE08E3F06" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X383</accession>
    <name>A0A0D2X383_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270437.1">
        <property type="nucleotide sequence ID" value="XM_011272135.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X383">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X383"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X383"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X383"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="657"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1563"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1306"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1399"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1565"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1640"/>
            <end position="1661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1661" mass="181599" checksum="E555F612DB99C99A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3N5</accession>
    <name>A0A0D2X3N5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346924.1">
        <property type="nucleotide sequence ID" value="XM_004346874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3N5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3N5"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3N5"/>
    <dbReference type="OMA" id="PCDHRSK"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3N5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="243" mass="25301" checksum="1D89C8E079143E03" modified="2015-04-29" version="1">MLPQSARALAKSCASTPLLGLKQASLSSSHSSKSMLGAVSVAAAASFTTTTTASRPQFWSSTAAATAPMSLLMHRACSCAFTAPVSTPAMHAVAAGTRRLASSTAPPPPPPSSPTSQAAEQAAAHGATSESKPTPVGSIDPSQGRFLIAFTCKPCSHRNSKTISKHSYQKGVVLIRCDGCKQIHLIADNLNWFQTGHRNIEEILRAKGQTVIRNPETILRDHGLDLAALSSSTVEINGSADSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X401</accession>
    <name>A0A0D2X401_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X401"/>
    <dbReference type="STRING" id="595528.A0A0D2X401"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X401"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X401"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="264"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="520" mass="57053" checksum="4DCAA9A30A70C973" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4B1</accession>
    <name>A0A0D2X4B1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4B1"/>
    <dbReference type="InParanoid" id="A0A0D2X4B1"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4B1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="347" mass="38834" checksum="71CD0D13593DF632" modified="2015-04-29" version="1">MAQCRSEETTDWRGRVVVESPLVSAEARTLAVKAAPEGEKHNVAVAVALKLVYQDSVTLQGGEIYRPTGWTTRAIAARLAEQGYQCGHTTVHGWKTKHTDSAEWIRSSPLDQVLQLVKESPSCGGQSIFTEDELEYCIRLLEGFARAGQCLNQKQAGAYLVKLSRLPRMSGAPRRQFAGSLPSHEWWNAFLRDARGRLAIRKGRTLELTRIAALQAETLDCLPGLLKQLFDEHPLLVEEPGRISNMDETEITTRFFAGRVICTPSLAKRLHEKRNMAENVRLRPMRRAREQAPDHDDDAPGRISQRARLDSPDQAVQAPPALVDLSHRPNHLGFVPAMFPSQHLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4G8</accession>
    <name>A0A0D2X4G8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345155.2">
        <property type="nucleotide sequence ID" value="XM_004345105.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4G8"/>
    <dbReference type="eggNOG" id="KOG3625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4G8"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4G8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="4">
        <location>
            <begin position="201"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="4">
        <location>
            <begin position="608"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="5">
        <location>
            <begin position="858"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1949" mass="214353" checksum="D8EB322AFD91FF36" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4I4</accession>
    <name>A0A0D2X4I4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4I4"/>
    <dbReference type="STRING" id="595528.A0A0D2X4I4"/>
    <dbReference type="eggNOG" id="ENOG502S6YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4I4"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="73" mass="8196" checksum="0D1D3011CE61BE5A" modified="2015-04-29" version="1">MGGGARFEFPRYVWSPTGGWWPEPKMWKRNTLLAGAFIVAACIPVYNLSKRLEASVQNAFIDLVLPIVGTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4R8</accession>
    <name>A0A0D2X4R8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344463.2">
        <property type="nucleotide sequence ID" value="XM_004344413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4R8"/>
    <dbReference type="STRING" id="595528.A0A0D2X4R8"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4R8"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4R8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF116">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="255" mass="26993" checksum="089EB13F93FC4043" modified="2015-04-29" version="1">MAFLRASLASCSLMAIGDTGIQLAQIYLQSSGSTTAPDSAASAEAKDRPRGQPAATAVPPPPPHPPLSTPPYVVALGSTGLELPPRILAELPPSLAGLLPDGFDGARTLRFATLGAVLHGPFFFYGFRQLDRIYGPAKTLAVAAKKAATGHLTLFPVFVTTFFTGMCMLERRSPESIEHKMSEVVPRTLMLGTLFWPAANMINFTLVPLKYRFVALNMFGIFWNSVLSVINSSAAAPLSVHAAAEASALVNTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X570</accession>
    <name>A0A0D2X570_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X570"/>
    <dbReference type="InParanoid" id="A0A0D2X570"/>
    <dbReference type="PhylomeDB" id="A0A0D2X570"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="579" mass="64808" checksum="817D796ADF063487" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X590</accession>
    <name>A0A0D2X590_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X590"/>
    <dbReference type="STRING" id="595528.A0A0D2X590"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X590"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X590"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255063" description="LRRNT domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="599" mass="61810" checksum="2779DA79BF0BD200" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X591</accession>
    <name>A0A0D2X591_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CMGC/CDK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X591"/>
    <dbReference type="STRING" id="595528.A0A0D2X591"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X591"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X591"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="340"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="876"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="888"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1157" mass="127247" checksum="A49FD1BAC079D69A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5C1</accession>
    <name>A0A0D2X5C1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343248.2">
        <property type="nucleotide sequence ID" value="XM_004343198.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5C1"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5C1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="188"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="495"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="770"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="905"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1382" mass="150006" checksum="610B12F149F22C04" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5F2</accession>
    <name>A0A0D2X5F2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="29">Aspartate kinase-homoserine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CAOG_007808</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:23777"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342881.1">
        <property type="nucleotide sequence ID" value="XM_004342832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5F2"/>
    <dbReference type="STRING" id="595528.A0A0D2X5F2"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5F2"/>
    <dbReference type="OMA" id="VTCNKIA"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5F2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04243">
        <property type="entry name" value="AAK_AK-HSDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="25">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="28">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="27">
        <location>
            <begin position="564"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="26">
        <location>
            <begin position="731"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KJE97704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="951" mass="101014" checksum="462899E3CFF75D68" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5N6</accession>
    <name>A0A0D2X5N6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342741.1">
        <property type="nucleotide sequence ID" value="XM_004342692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5N6"/>
    <dbReference type="FunCoup" id="A0A0D2X5N6">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5N6"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5N6"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="567" mass="59933" checksum="683EC878B0F3FF93" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1W2</accession>
    <name>A0A0D2U1W2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365572.1">
        <property type="nucleotide sequence ID" value="XM_004365515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1W2"/>
    <dbReference type="eggNOG" id="KOG0765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1W2"/>
    <dbReference type="OMA" id="GPSGILM"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1W2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF18">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="260"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="38436" checksum="A95B2CA88420551E" modified="2015-04-29" version="1">MAHQTASASASPLPPPPQVARSLPMEINWKDLDFARYTVIGSTLLLGVRTLVYPLALAKTRLQVQRSHPAPTAPGATPPVVYRNVFHVWSGIARAEGLRGLYRGFMTTVVGITPAQAIYLTSYEYVKSHAQRFERPEWSQDKKTLHQNLIAGFLSSVCSQVIIVPIDVIVQRQMVQGTQSAAGTAVEAARGGYAEFRHILATQGVRGLYRGLHLSLMLYPPSSAIWWATYGATKQGLHDLKDAWFGSDSADANDIGRHAQGFAIQTVAGLFAGFTSGCITTPLDVIKTRYQLASRGNGAAPTVAGTIRTLLQEDGMAGFTKGMTARVMHMAIPSVLMISVYELTKRLSVVDAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U251</accession>
    <name>A0A0D2U251_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000804</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365675.2">
        <property type="nucleotide sequence ID" value="XM_004365618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U251"/>
    <dbReference type="STRING" id="595528.A0A0D2U251"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U251"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U251"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="194"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="838" mass="91208" checksum="3F00DE56425BD6B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U494</accession>
    <name>A0A0D2U494_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_001380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349900.1">
        <property type="nucleotide sequence ID" value="XM_004349850.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U494"/>
    <dbReference type="FunCoup" id="A0A0D2U494">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U494"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U494"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U494"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252471" description="Endoplasmic reticulum chaperone BIP" evidence="16">
        <location>
            <begin position="22"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="655" mass="71663" checksum="F72600609F0D11F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4S6</accession>
    <name>A0A0D2U4S6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4S6"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4S6"/>
    <dbReference type="OMA" id="HIRFCVE"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4S6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="592"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1315" mass="138592" checksum="C8783DDF5FEAD7CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U786</accession>
    <name>A0A0D2U786_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348960.1">
        <property type="nucleotide sequence ID" value="XM_004348910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U786"/>
    <dbReference type="InParanoid" id="A0A0D2U786"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U786"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="71" mass="7845" checksum="4E066BB1F005EFA5" modified="2015-04-29" version="1">MSAMTAIIADVKQYKEILPLLAVVGTAVTYGVGSMIHTARKTDVVFDHRNNPFPWQQVAETAAPKAHQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7Z0</accession>
    <name>A0A0D2U7Z0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7Z0"/>
    <dbReference type="STRING" id="595528.A0A0D2U7Z0"/>
    <dbReference type="eggNOG" id="ENOG502S7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7Z0"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7Z0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF8">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253240" description="MACPF domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="8">
        <location>
            <begin position="117"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129928" checksum="6333BFC3B194BBA5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAV6</accession>
    <name>A0A0D2UAV6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364010.1">
        <property type="nucleotide sequence ID" value="XM_004363953.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAV6"/>
    <dbReference type="STRING" id="595528.A0A0D2UAV6"/>
    <dbReference type="InParanoid" id="A0A0D2UAV6"/>
    <dbReference type="OMA" id="SERRMQE"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="748" mass="81762" checksum="21289E0E0EE52CBF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDM2</accession>
    <name>A0A0D2UDM2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDM2"/>
    <dbReference type="InParanoid" id="A0A0D2UDM2"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDM2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="21414" checksum="3C05704444677899" modified="2015-04-29" version="1">MRVQPKKEPSPATSALNAATAAASIVPQSPVTLTTEIQQLRSELAAKDQELAVKHQELARKEQELGAKEQEIAAAKLEHAAAKLEHAAAKLELADERQLRAAKEQELQKLLLGVADREDWIDGVTGSTLAKHLEAPSSALLLSASVQLDSRRPLKRVNDNLGHQVDAVLLVIIFQGLGCSGIPLPNQHGDVMASETGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDZ7</accession>
    <name>A0A0D2UDZ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347956.1">
        <property type="nucleotide sequence ID" value="XM_004347906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDZ7"/>
    <dbReference type="STRING" id="595528.A0A0D2UDZ7"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDZ7"/>
    <dbReference type="OMA" id="QFYADVQ"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF15">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="5">
        <location>
            <begin position="176"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="33203" checksum="C99A7A2FABF4EB32" modified="2015-04-29" version="1">MASPLNLTAGNCRVGWIGTGVMGRWMCEHVMKAGFTNMTVHNRTEAKTEPLRALGARVVATPREVAENSDVVFTIVGYPKDVRETYLGADGVLAGLKANGVCVDMTTSQPSLAEEIAKAAKAKGIYAVDAPVSGGDVGAKNATLSIMIGGEEAAVEALRPLFSAMGKNINRLGGPGAGQHTKMVNQVLISTTMIGVVEGLLYGYKAGLDLVDVIKAVGAGAAGSWSINNYGPRMIKRNFDPGFFVNHFVKDLEIALDESRRMNLSLPGLALAHQFYVALKAQGHGQLGTHSLLLAFEQMNHTKIDQPEKPASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF92</accession>
    <name>A0A0D2UF92_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF92"/>
    <dbReference type="InParanoid" id="A0A0D2UF92"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42835" checksum="8903F07980DA2923" modified="2015-04-29" version="1">MSESQRELLDRDQIGDVGAQAVAEALKVSRTLVSIDMRANQIGAVGARAIAETLKVNKTVVEVALSQNQIGDAGARSIAETLKVNTNLRWLTLSSNQVGDAGARAIAATLKVNTTLKYLYLYHNQIGDAGAQAIAEALKVNTNLIWLHLKLNRIGDAGAQAIAAALRVNKTLTELTLGRNCIGKVGIRALEKARKVNGILTELDVEEQINPLAFSFLPRLTTSEDWQSVFHLLTGRHELENQPALLPALPAEIAELVMDEAEYFQGVQHIHQAWSRYNRLEFLKLTMPRSSDGNSIRVKAIQVLRERQSEAKSDPFDLIVRDELGAVRYKWAAEAPVVGSNIQLVTISPTDHPVIRQLRAGWEVEVQFGQSSCFVRFASLSVGYIERQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGP9</accession>
    <name>A0A0D2UGP9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter mdrA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347681.2">
        <property type="nucleotide sequence ID" value="XM_004347631.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UGP9">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGP9"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGP9"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGP9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="118"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="794"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1396" mass="156611" checksum="35E5070AD2FD60CE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGS7</accession>
    <name>A0A0D2UGS7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346647.2">
        <property type="nucleotide sequence ID" value="XM_004346597.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGS7"/>
    <dbReference type="eggNOG" id="KOG4751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGS7"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="9">
        <location>
            <begin position="984"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB3" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1337"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1626"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1694"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1626"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1706"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1753" mass="185337" checksum="3505380AF03DAD58" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI58</accession>
    <name>A0A0D2UI58_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347073.1">
        <property type="nucleotide sequence ID" value="XM_004347023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI58"/>
    <dbReference type="FunCoup" id="A0A0D2UI58">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UI58"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI58"/>
    <dbReference type="OMA" id="PVARCIY"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="318"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="663" mass="71476" checksum="E4C2791CF7056EB9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJT8</accession>
    <name>A0A0D2UJT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345410.1">
        <property type="nucleotide sequence ID" value="XM_004345360.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJT8"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJT8"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="828"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1312" mass="139392" checksum="422AF318A29441E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UME0</accession>
    <name>A0A0D2UME0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UME0"/>
    <dbReference type="InParanoid" id="A0A0D2UME0"/>
    <dbReference type="OMA" id="KMMGGAP"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="412" mass="40272" checksum="8D16A2C7CCFF84CD" modified="2015-04-29" version="1">MPGLSNGALQVNLQGARRKTEESPSWQKEVAINKLGKSKEKEAAPVSGELADKLRRKSETIEQAQKQEQAEKNAPEFEKKLKSMSAARDQKEKEKEAGLVRNNTPTIDVGVSPSAASSAFGSTLKKSPGPNTTASNPTTPNTPLTPSSATSGTSFKISPSSSGNNLAASASPAAASKAGASAAAAAAAAPAPAPAADTTPAWKKSLTSSATTPAAAAAAAAAPAPAPAADTTPAWKKSLTTGAASTTTPAAAASSAATAGGAGLATPASTPSWKRNSSGAAITPEAAAAAVAGATPTTSSTASPRTSFTGTPGSSADNTPSWKKNSTAGAAPAGTTATVQRTPSTSTPATATATVQRTPSTTTPATASAQKPAATTPAATAAATPATVSPPAASTDNLPAWKKELLASRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP69</accession>
    <name>A0A0D2UP69_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270720.1">
        <property type="nucleotide sequence ID" value="XM_011272418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UP69"/>
    <dbReference type="STRING" id="595528.A0A0D2UP69"/>
    <dbReference type="ESTHER" id="capo3-e9cg20">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP69"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP69"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="115"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="388" mass="42757" checksum="97824C07B948E462" modified="2015-04-29" version="1">MSMLADFGWVVLASGTAIVATALLMARIATHRTPPTLHHHPESRLARTLRNNMKTLSRQFLPTWWALNGHAQTVFGVILRTNPDVAYERELVGMSDGGQVALDWHDIPDMEESTPLVVVLHGLTGGSNENYVKHIVLEAERNKWRTVVFNNRGCGNSVAITPRGFSATFTDDIAEVVQHVHAKHPKAPLFAVGVSLGSMILIKYLAERGTSTALQAAVAVSNPWDIIGSTKSLESFPSLYLYNQRLAKNLKNLIFRHRHLFDAAPEKWFTIEDVEKCRTIRDFDQTVVVPMFGFASLQEYYSQASSVNHLPKVQIPLLCINAADDPFSPVQGIPFAAFEANPNALLCLTPTGGHIGFSESHLPPFGSSFVESALGEFLHCMLAHQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPP1</accession>
    <name>A0A0D2UPP1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPP1"/>
    <dbReference type="InParanoid" id="A0A0D2UPP1"/>
    <dbReference type="OrthoDB" id="3250442at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="243"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39026" checksum="120D7629C57A9F23" modified="2015-04-29" version="1">MLTYANMNQRQRELYDEVMNGPNYVEYEAEFIGMNVAVGALTKWRNSLHDREIGDAEALAIAEALKVKTTVTMISLLHNEIGEVGARAIAETLKVNTRLTFLFLGCNHIGDAGAQAIAEALKVNTTLTTLFLGWSQIGDAGAQAIAEALKVNATLTELFLWHNEIGDAAVPSIVEALKVNKTLKTLELHGNCLSRGAIDALTQTGNTCITCGKMRVQPKNEPSPATSALNAATAAASIVPQSSDTLATENQQLRSELAAKDQELADERQKLAAKDQELAMKEQELAVKDQELAAKEQEIAVKEQELAAAKLELAAAKQELADERQLRAAKEQELQLLLGVADREDWIDVKSPADDDKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQV3</accession>
    <name>A0A0D2UQV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343129.1">
        <property type="nucleotide sequence ID" value="XM_004343079.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQV3"/>
    <dbReference type="InParanoid" id="A0A0D2UQV3"/>
    <dbReference type="OMA" id="RVMPEHE"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="279" mass="28579" checksum="A67624011BCB59BC" modified="2015-04-29" version="1">MTTLGSANGSRILSLSGVSSPRSPVATIGGTISLKQVTQSSPSPLGSLSGKGPAAQQASGSLLNPAKSSTPSPSQAGHHQHHHHHHHHHAHHAHHAHPKEHEAEDGSNASPAPRRTLISLSAVTAGSPGSSAASTAAAMRRVMPEHEGRYVITYPKSRSSASVSSDASESESSVITAAAEGAFTPSKKAKAGATVTPVQARVKVIATSASAASPARISKATATTAANTKNATVLQRVVAAVSSPQQQLQQLSESDAAEHARRQQRRNRFAAPAPTSQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT55</accession>
    <name>A0A0D2UT55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342746.1">
        <property type="nucleotide sequence ID" value="XM_004342697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT55"/>
    <dbReference type="STRING" id="595528.A0A0D2UT55"/>
    <dbReference type="InParanoid" id="A0A0D2UT55"/>
    <dbReference type="OMA" id="VDYSSMF"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="949" mass="103236" checksum="9D0010008AFE0568" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG38</accession>
    <name>A0A0D2VG38_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365244.1">
        <property type="nucleotide sequence ID" value="XM_004365187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG38"/>
    <dbReference type="InParanoid" id="A0A0D2VG38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="116" mass="11469" checksum="8851944731A543B6" modified="2015-04-29" version="1">MSTTDPAKRPLGSSDEGSSEENPNKRARLEDPAAAVAAAAATAAVPVFVAPCTTTSLQAASTAAAPLTLTTSPATAMMTTTELAASAPPNSHTTSSTETAPAVLPRAVLGTHLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI74</accession>
    <name>A0A0D2VI74_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI74"/>
    <dbReference type="InParanoid" id="A0A0D2VI74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="491" mass="55542" checksum="3F7718999003FE72" modified="2015-04-29" version="1">MQFLQAIVQEDHGAGNVLQNGAFVLPGNLGEIVIVGEEACQISRLDAFIHEGVVLRSERDVDNRCEKGMADLDHFLEFSLKHVEFAVCQVPFEALDGDEPLVCGSGWGCCCRDRGKLALSENASQHVLLQGDARRCKISLHIGHRITAVDCVAWRSKQRVCARMRLSWIHTIAFRQQIYLRVRDCQLRSRMARSRRRRLLLLHLHDMVGWWSWSWSWSCSCAGLLENTLNSWARRSSRTPKVAGAVAGGPHNTGTRNRRSEISAQSHWLWRHGRCKVAVKRLGGWRSGTDRTLRVGWNILINSVGDLRNMAVAVGRDVAVGGLLHRGGGRGWAHSALDGHRTGPGRKSRRGNLVGCDNNRTIRKARRAQRGAWWRGIAELFLDKRQHPILFFAHRRKLVAVFFGLSGRFFAMSFVFLGHFFAMRFLASTKFFVFLRRSCESFGPIEFLLGGNFHQLVVNSGTLNRQSQHHVAFLLLQPFVEVFNLRSVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMY5</accession>
    <name>A0A0D2VMY5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270228.1">
        <property type="nucleotide sequence ID" value="XM_011271926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMY5"/>
    <dbReference type="FunCoup" id="A0A0D2VMY5">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMY5"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMY5"/>
    <dbReference type="OMA" id="YMSIAMK"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31669" checksum="72379BDABA3BEE75" modified="2015-04-29" version="1">MPRVVLITLVRHGQTEANKSSIIQGQTDIPLNDHGRRQAEHAAQSLAATKVDAMYTSDLSRAHETASIIHRRLKQPCELIVDRRLRERSCGVFEGKPWGSARKHAEALGIPHYEFRPEGGENSADVRARVATMLHDIVQNQAKVVHESLTHETASLHHVVVVSHGGLISDLLHYCRDHALLDLNGHTVTIPLNTSLTTLVVQVPETADSSTRDFQELDGAAIVQHHNHDHHQQQHPHALPVHHHTHHEHRHWSVKIHRFNDVEHLRELEQIVAPHNISDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMZ4</accession>
    <name>A0A0D2VMZ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMZ4"/>
    <dbReference type="InParanoid" id="A0A0D2VMZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="239" mass="26172" checksum="1096AC841F21EA3B" modified="2015-04-29" version="1">MDGQDGASPKYDVSGRRASRPRKAFQTASRRVGRISHATVAQHVAAVYLGQDTHGGLQGVSATSGSNMPDILQNPGMVKSTLRIRVSQRVEITSFMDELIKRLEATDDGNDGPLSNWSALRAALAPYRPPPAPGSPRRLVHPKTGFPLKEVTLVIRQLIAPTALVMALGGESKLAVYSEMTESDFFERLGEESYDGVRLRDAIEFRPGVGLTDYRNEMQNEIRGPVSASFQIRRITPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNM0</accession>
    <name>A0A0D2VNM0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363823.1">
        <property type="nucleotide sequence ID" value="XM_004363766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNM0"/>
    <dbReference type="STRING" id="595528.A0A0D2VNM0"/>
    <dbReference type="eggNOG" id="KOG4014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNM0"/>
    <dbReference type="OMA" id="PGCINAG"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29420" checksum="ED64DB7250547B35" modified="2015-04-29" version="1">MPGGGSDDAAHTTNHQKQNQNQSSTPDKDVAARVFFENMYKLLVDDCYVLRKTTGCHELAEFIYGVHRNPKAAAELYEANCLTRHNAKSCFRSGVLAFDGEGVARDSVRALARFRRACELGSAEGCNNAAMMFQRGVGCPADLDVAERLFLKACDQLLYTNACYNLSSFYLLGGVVPPAPPKLKPGETPPATRPPLPPANKELQNLPKALEYSLRGCEYGHPYACINASRMYLTGDGIPKDEVKGTYYRRQAEELLQIYVPSSPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP21</accession>
    <name>A0A0D2VP21_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363979.1">
        <property type="nucleotide sequence ID" value="XM_004363922.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VP21"/>
    <dbReference type="eggNOG" id="ENOG502QVMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP21"/>
    <dbReference type="OMA" id="DFNVKVM"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043513">
        <property type="entry name" value="Cenp-F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18874:SF10">
        <property type="entry name" value="CENTROMERE PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18874">
        <property type="entry name" value="CMF/LEK/CENP CELL DIVISION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1787"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2050"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2248"/>
            <end position="2272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="745"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1791"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2050"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2248"/>
            <end position="2257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2361" mass="255380" checksum="F0ABB6B254B30B1C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP26</accession>
    <name>A0A0D2VP26_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP26"/>
    <dbReference type="STRING" id="595528.A0A0D2VP26"/>
    <dbReference type="InParanoid" id="A0A0D2VP26"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="265"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="683" mass="77101" checksum="264476849AF2B3E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ52</accession>
    <name>A0A0D2VQ52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_003612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363340.1">
        <property type="nucleotide sequence ID" value="XM_004363283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ52"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ52"/>
    <dbReference type="InParanoid" id="A0A0D2VQ52"/>
    <dbReference type="OMA" id="MQNAYRK"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ52"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE92697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="79" mass="8624" checksum="12ECD5E68AD9076F" modified="2015-04-29" version="1">MASGFGAFGGRGRCFPLWSDFVDCARDATQPMQCAAQTEDYLECLHHVKQGRRDRAIEAERKKQAANPPTHAAAAPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRZ5</accession>
    <name>A0A0D2VRZ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2VRZ5">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRZ5"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRZ5"/>
    <dbReference type="OMA" id="KPMPTPG"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRZ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="39"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="13">
        <location>
            <begin position="773"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1361"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1435"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1477" mass="156770" checksum="8A453D603FE3554B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRZ7</accession>
    <name>A0A0D2VRZ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348333.1">
        <property type="nucleotide sequence ID" value="XM_004348283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRZ7"/>
    <dbReference type="STRING" id="595528.A0A0D2VRZ7"/>
    <dbReference type="eggNOG" id="KOG3011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRZ7"/>
    <dbReference type="OMA" id="KFVWTCY"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRZ7"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="8">
        <location>
            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="309" mass="34054" checksum="77933E6B5A53FDDB" modified="2015-04-29" version="1">MVFTSSDCALGGGVSAPQQPHANAKQTDDAAPDAPRRSLNQIAASVAGAASPASAEAELHSPRWGKDNAGAKLLAAQYTPEKRRFEIISVTTCASLTAINLLCIAFNFSSANAIGVIVSIVLGIFTADFLSGLAHWAADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDVIETNGDNCFVTIPFHIYIALSFWTVSDMAGAGRAAYFANCYLFAMSIFVTLTNQIHKWSHTYKPPGWVQLLQDMHIILPRKHHRIHHVSPHDTYYCITTGWLNYPLEMIDFWVRLEKALCAVTGVPPREDDLKWAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV74</accession>
    <name>A0A0D2VV74_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345400.1">
        <property type="nucleotide sequence ID" value="XM_004345350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV74"/>
    <dbReference type="FunCoup" id="A0A0D2VV74">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VV74"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV74"/>
    <dbReference type="OMA" id="NKRGCHC"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="193" mass="22297" checksum="167CBD6C1109A1EC" modified="2015-04-29" version="1">MSKSNFVKEYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDILDTAGQEEYSAMREQYMRTGEGFLCVYSITSRQSFEEIQSFHQQILRVKDRDEFPMILVGNKSDLEHQRAVSSDEGKHLAKTLKVEFSETSAKQRLNVDHAFHQLVRIIRRYNKDNLPKNPEKKKKLKCLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW27</accession>
    <name>A0A0D2VW27_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345722.2">
        <property type="nucleotide sequence ID" value="XM_004345672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW27"/>
    <dbReference type="STRING" id="595528.A0A0D2VW27"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VW27"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="6">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="225"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="373"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="644" mass="69764" checksum="415B63826269FF0D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX90</accession>
    <name>A0A0D2VX90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD51 interacting motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345341.1">
        <property type="nucleotide sequence ID" value="XM_004345291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX90"/>
    <dbReference type="InParanoid" id="A0A0D2VX90"/>
    <dbReference type="OMA" id="KTRRYES"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="47553" checksum="AAB4CB5328C78CC0" modified="2015-04-29" version="1">MSRPQRASASRTSSYANQDDDDDDDDDDNEQDSGDEPGLNADNDDNDDKDDKDDKERAEQAPTDSDSKPATPAKKPPNKRQSRVSNDDDDDELQRVLELSKREATHGGVAVEMDVQQDEATTSARVAPAKRKAAVMDDSDDQDLGKPADGTKNDNNNDNSDDDDDESADEAAPKPKKQPAKRAAPARKKTRRYESDDSADFDADDGGGKSSESEAESDFDGNSDSDSGKKSKKKKAAAPKGKKAPAAPKAPRAPAAKKATKGAAATAGTGAAAAKKAATVPAAAAAAKKPAAATAPAARPALAKPAVGAARSIAPPRRTFTTPASVAAPSRDSDDEGESTTRTRAYNDDEEPSRNSRDAEFDDNEDGNYDRAQRKRGSDADEEDDEPVVKRKPAASYTPVRPAGVASPSAQSAGRVALAGGGRVIIPGGGGTPFRRVGLSRSSNVPPLHPNMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W012</accession>
    <name>A0A0D2W012_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W012"/>
    <dbReference type="FunCoup" id="A0A0D2W012">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W012"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W012"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W012"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="3">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="2">
        <location>
            <begin position="141"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="318" mass="37184" checksum="FCEAA902C585F107" modified="2015-04-29" version="1">MSSMGEVDHPLCKECSDQLVESLEDDLLDAEQELNYYREFLARSQEEDADPRDSALEREELQKLRFEEAGLQQRVFQLETDREIASQELASLTVQQAEVDRDSEVYWKEYSEFQRQLREFLEEHDCIEMRLQNASASLSRLNKTNIYNDTFHIWFEGHFGTINGFRLGRLQNSPVDWAEINAAWGQTALLLQSMAERLKFTFNKYRIVPLGSYTRIENVEDETRFELYSTGASKLFNFGQSSFDSAMIAFLDCLQQLTLHVESRDPQFHLPYPVVKDKIGEQSIRFVNSKLETWTKALKNLLTDLKWCLAWVSKMIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0M6</accession>
    <name>A0A0D2W0M6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">2-oxoglutarate and iron-dependent oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342963.2">
        <property type="nucleotide sequence ID" value="XM_004342913.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0M6"/>
    <dbReference type="FunCoup" id="A0A0D2W0M6">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0M6"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0M6"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="229"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="597" mass="66265" checksum="D53D284DCAFF32C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGJ3</accession>
    <name>A0A0D2WGJ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGJ3"/>
    <dbReference type="STRING" id="595528.A0A0D2WGJ3"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGJ3"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="431"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="840"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="756"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="904"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1096" mass="119796" checksum="D009F6BE9016142A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGV6</accession>
    <name>A0A0D2WGV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365176.1">
        <property type="nucleotide sequence ID" value="XM_004365119.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGV6"/>
    <dbReference type="STRING" id="595528.A0A0D2WGV6"/>
    <dbReference type="eggNOG" id="KOG0606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGV6"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="359"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="848"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="892" mass="95682" checksum="025B467D17164689" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHS3</accession>
    <name>A0A0D2WHS3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHS3"/>
    <dbReference type="STRING" id="595528.A0A0D2WHS3"/>
    <dbReference type="InParanoid" id="A0A0D2WHS3"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="398" mass="42860" checksum="8A0AAA71DDC9D2E9" modified="2015-04-29" version="1">MAPYIRTVRVLAARQIAAQKASSSEEEEVAATEEGATGLVTSISSAANILMMAKKRASKRGSASAAADDPYARPSPGYQQRLSTSDRIIADVELGFQAPLAKIVVSIKLGGKFIGLTLPVQLKEIDFAGTMRTNVKLIDQFPHLDSITFGFLNMPRVRFAIQPLKTIDIMDVPKLSEWLYGMVEDALRTSVVDPHNITINLNSNKANALMFFSDIYKLSTALYVVRVSRITNSTPPPLTPSGTKQASSVAVIDRSTEEGVGGGGSVPAGGPPKLVRQFTLDTITPTKANAPVAIQPGAAMPDSSAEGTLDLYCTVKIGDDKRRTEVLRVACARTPQGVSPTNVASNNFDTPFVFLTSQPEFDTMTLTVRRKRKLKNETLGCKELALYSLDDATGKHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHT1</accession>
    <name>A0A0D2WHT1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHT1"/>
    <dbReference type="FunCoup" id="A0A0D2WHT1">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHT1"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHT1"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHT1"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="10">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="11">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="421" mass="45686" checksum="4639AE60E3C492CB" modified="2015-04-29" version="1">MVLLGAWWCEFRPKSKAVVPVLGAVQNYAWGRLGSASNVAQLAFANAQSSPADRFAIDENAPYAELWMGTHPKAPLRFKSEAGNVVGPARPITDDARFATLPFLFKVLSIKKALSIQAHPTKDLARVLHARDPQNYPDDNHKPELAIALTDFVALCGFRPLERIRDAICSVPELASLVGGKDSAQALLDGPVDARRLALKRVFSCLMKADRDSVSKQLQLLVDRLQSQPNLNEDEDSKLILHVVQDFPGDVGCFVIYFLNVVHLKPGEGMFLAANEPHAYIKGDCIECMSSSDNVVRAGLTPKFMDVDVLLEMLTYESRLPAEQLLHPKKQPSLGFVATFQPPVQEFAVTRAVAETTGAQLELAAQPGPSLLIVTSGAAVVKSSGDQSVAYGSVLYIQPGTPLAMTSTSGRFEAYQAFSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHT8</accession>
    <name>A0A0D2WHT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364916.2">
        <property type="nucleotide sequence ID" value="XM_004364859.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHT8"/>
    <dbReference type="InParanoid" id="A0A0D2WHT8"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052798">
        <property type="entry name" value="Giardia_VSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23275">
        <property type="entry name" value="CABRIOLET.-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23275:SF100">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="95"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="80"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="73"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7142"/>
            <end position="7164"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="930"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="930"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="1603"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="1646"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="2191"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="2191"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="2611"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="2611"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="2906"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="2906"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="3201"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="3201"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="3414"/>
            <end position="3455"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="3414"/>
            <end position="3455"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="3497"/>
            <end position="3538"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="3497"/>
            <end position="3538"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="3790"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="3790"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="4085"/>
            <end position="4126"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="4085"/>
            <end position="4126"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="4214"/>
            <end position="4252"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="4214"/>
            <end position="4252"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="4298"/>
            <end position="4339"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="4298"/>
            <end position="4339"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="4384"/>
            <end position="4420"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="4384"/>
            <end position="4420"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="4721"/>
            <end position="4762"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="4721"/>
            <end position="4762"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="5014"/>
            <end position="5055"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="5014"/>
            <end position="5055"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="5309"/>
            <end position="5350"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="5309"/>
            <end position="5350"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="5396"/>
            <end position="5434"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="5396"/>
            <end position="5434"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="5899"/>
            <end position="5940"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="5899"/>
            <end position="5940"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="5942"/>
            <end position="5984"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="5942"/>
            <end position="5984"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6027"/>
            <end position="6068"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6027"/>
            <end position="6068"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6156"/>
            <end position="6197"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6156"/>
            <end position="6197"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6685"/>
            <end position="6722"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6685"/>
            <end position="6722"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6756"/>
            <end position="6794"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6756"/>
            <end position="6794"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6884"/>
            <end position="6926"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6884"/>
            <end position="6926"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="6952"/>
            <end position="6992"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="6952"/>
            <end position="6992"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="7016"/>
            <end position="7061"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="7016"/>
            <end position="7061"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="7087"/>
            <end position="7125"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="7087"/>
            <end position="7125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="7190"/>
            <end position="7229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="7315"/>
            <end position="7339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7217"/>
            <end position="7229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="6773"/>
            <end position="6786"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="6776"/>
            <end position="6794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="6974"/>
            <end position="6992"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="7037"/>
            <end position="7050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="7104"/>
            <end position="7117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="7350" mass="726931" checksum="B82529257FB539F8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI91</accession>
    <name>A0A0D2WI91_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365860.1">
        <property type="nucleotide sequence ID" value="XM_004365803.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI91"/>
    <dbReference type="InParanoid" id="A0A0D2WI91"/>
    <dbReference type="OrthoDB" id="9939609at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="289" mass="30538" checksum="D18D8591A337AFCB" modified="2015-04-29" version="1">MLASASRIAAGRRLLSSAATAARPQAAASTPSFNAAAKAGSGDAPAAAAAEEQGGASSGGLLARTFGRLRGAKATDGAAPTTTAATAAAAVTGDAKTAAAGSADSEAIRAHRALHARRASEAPAILTPAVMDEEHIIRRTVINHYRSKTPLVYQDAQGQSKTISESRAAKILKQTRKSYLERRYAALVPRTDLDVRQTVREIVNEIAPIPADAKDAVWTSRAFDSQTERVQILARCVETFQRDIPDHLLSEMKNAAGVVKFFKSPLPAAPRLFPSIDLEKLPPNLRIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIL3</accession>
    <name>A0A0D2WIL3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365357.2">
        <property type="nucleotide sequence ID" value="XM_004365300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIL3"/>
    <dbReference type="STRING" id="595528.A0A0D2WIL3"/>
    <dbReference type="InParanoid" id="A0A0D2WIL3"/>
    <dbReference type="OrthoDB" id="1724750at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIL3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_bL9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="Ribosomal protein L9 C-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="5">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="317" mass="34569" checksum="C215E7C2E820BB89" modified="2015-04-29" version="1">MWLPSLTSSAAVARTAVVAVAARSSAMLSGPARPAPSAAMARSLSLSAASSAMLLSQRGAGRLPAMPLAVAATSSPLHQQQSRSLTTGRRIRKLAIKRNKVILLQDISDVGKRGQVIAVRPGFGRNNLVMYGKAQPLHIFRQETEALYGREVYDRFAELSKRLEPKKESATDELAHLDDVQFDLSWEGITFWMAEDSPATTARLTFGVSAEDVIDQVRQHHNVSLARSSLPADFPPIKTPGTHFVTLRLTDESITFLTVTIDTRSRAEMRDLLNSAEAEAEEDEPEENGEVEPTPKAEGDDFFQSLFSTPSDSALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ60</accession>
    <name>A0A0D2WJ60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365660.2">
        <property type="nucleotide sequence ID" value="XM_004365603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ60"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ60"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ60"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="646" mass="73778" checksum="1DE36210A0B565AC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK12</accession>
    <name>A0A0D2WK12_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK12"/>
    <dbReference type="InParanoid" id="A0A0D2WK12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18260" checksum="EF755F7706BDBCA5" modified="2015-04-29" version="1">MEARALQNDLHSRDIRVQGPVAARGGVHEQAGAATQAINTQTSCWSLCRKCHWNKARYGSIGAAIPKPRPPAAANTQAAAVRPKACRWSGVCRSVVRLACSATQPRELCYNRDARGIRRRADPRLYSCFWHWCRHDAAARHGRQLLLTMADSCMLNEAATEQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKI9</accession>
    <name>A0A0D2WKI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKI9"/>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKI9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="744" mass="81203" checksum="A6EEDFFAFE76B0A4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKJ6</accession>
    <name>A0A0D2WKJ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364322.1">
        <property type="nucleotide sequence ID" value="XM_004364265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKJ6"/>
    <dbReference type="STRING" id="595528.A0A0D2WKJ6"/>
    <dbReference type="InParanoid" id="A0A0D2WKJ6"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKJ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="333" mass="36504" checksum="54232DAD39BBACE1" modified="2015-04-29" version="1">MATKAAAPTALVAVSLDDEALKQRLILDEKRFNDLLRDVRKWMAPSEPAASSTPVPMAEEDEASAAATASVAPLPSQDELIEANLVLKESLLAGIATIQSTIAKSSLVVQMNTLQMAQLDATEARIQSEVEATRREISELKQTLELEKQLRANRQVYNKKASEVLKWESRTEAQNRIRRIEEEIQASQAEREKVEARIQLRQRQFSLLLHAAHQLQLVLYDQDSSPEQDLLDRMRQLQQAEDEENAAAAAAAEEAAAAAAALANGGDEPASSTGSGGIRRVREEDLDEDSARHAFKRPREATDTDAAGNFDQVEEDAETSANADIADEVVPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKM5</accession>
    <name>A0A0D2WKM5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364385.1">
        <property type="nucleotide sequence ID" value="XM_004364328.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKM5"/>
    <dbReference type="InParanoid" id="A0A0D2WKM5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="333" mass="37355" checksum="8ECF3989F9FA656C" modified="2015-04-29" version="1">MQSYPPPPFPHYGAPYGYPPNYPPYPYPYWSAPHTSYFQPPPPPPPPLPPHFPLPSSQQYFQPHTQPQLPLAPQPVPPPATMPTVPPTKEKTRKVGHFTEVTFEAGVAHSKSLTPSLIAKKPRKKRQSAKAKRPASDAKQPKQPKQPKQPKQSKPLVFKESTLSPSELSFRTAPLPFDGFHKPDHITTLLFKRAGTEPELVFNERLSRLGKKLIRANIGFLYSARTIQRWTDGRLWSKAYITKAGWKVYREVEILEDKGSTKPPKARTLAGGLYKKVLSGPEPDSELRLVIYTRTAPDVRCTLVAPVKDPTAGHSEPSDEEELDELDDETPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKM7</accession>
    <name>A0A0D2WKM7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGC/PKA protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKM7"/>
    <dbReference type="STRING" id="595528.A0A0D2WKM7"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKM7"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKM7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="554"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="808"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="991" mass="108801" checksum="4E6ABA2F9575D8B6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKQ0</accession>
    <name>A0A0D2WKQ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348893.1">
        <property type="nucleotide sequence ID" value="XM_004348843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WKQ0"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKQ0"/>
    <dbReference type="OMA" id="XSAMQKA"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKQ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="6">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="688"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="490"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="738" mass="83007" checksum="ED82D171F4A8D095" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLR8</accession>
    <name>A0A0D2WLR8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLR8"/>
    <dbReference type="eggNOG" id="KOG3709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLR8"/>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="6">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="6">
        <location>
            <begin position="408"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="5">
        <location>
            <begin position="1568"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1547"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1693"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1705"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1798" mass="190891" checksum="79D9CFF9A9920C18" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLW9</accession>
    <name>A0A0D2WLW9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349524.1">
        <property type="nucleotide sequence ID" value="XM_004349474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLW9"/>
    <dbReference type="STRING" id="595528.A0A0D2WLW9"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLW9"/>
    <dbReference type="OMA" id="EKKAADX"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27520" checksum="F53C5ED0D10ADA67" modified="2015-04-29" version="1">MDAIKKKMAQIREEADANLERAQQLEVELKDARERADKAESQAEAATRKMRLIEDDLETAESRAADFQKRCGEAEKRAEESERSRRVFESQQSSDDDRVETLQAQVNAARKKADDLEKDAANANRKVTLLENDLERAEDRAIAAEKKLKDLERSLDDANASLKSVKVSDRFDRSDELQDKLKQVEDKYRSADLRAEAAERKIRDLENQLEKIDDAYDREKAAHAKCQAELEEIQAQLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM35</accession>
    <name>A0A0D2WM35_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349045.1">
        <property type="nucleotide sequence ID" value="XM_004348995.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM35"/>
    <dbReference type="STRING" id="595528.A0A0D2WM35"/>
    <dbReference type="eggNOG" id="KOG4226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM35"/>
    <dbReference type="OMA" id="EPWITAP"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM35"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="5">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="63090" checksum="FD69C7AFF96C0635" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMH0</accession>
    <name>A0A0D2WMH0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAMK/RAD53 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363900.1">
        <property type="nucleotide sequence ID" value="XM_004363843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMH0"/>
    <dbReference type="FunCoup" id="A0A0D2WMH0">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMH0"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMH0"/>
    <dbReference type="OMA" id="MLCAVQY"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22666">
        <property type="entry name" value="FHA_CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="479" mass="53336" checksum="2B0F95F4DEB49CD5" modified="2015-04-29" version="1">MSSSLEEVNPTPEVGMTQELHSPPDADINEVERPWAQLLPLHQDYHSIDLIAASYVFGRHTSSDFLLKDPSASNTHCRIFQEMDDQGSSMLAFLEDLSSNGTFINDRKVGKGKRQVLNHGDEISVAHPKRKIYSFHDLSNAADRDTLTDCDEINARFGLRKVLGRGASGEVKLAVDRATGEQFAVKIIPKSKANTPKQKESVLSEGRILSTISHPSIIRVFDMFETPNTFYIVLELVNGGELFDLIVKESKFKDAEAKFLFRQMLLAVKLLHDNDIAHRDLKPENILITQVDDDTLIKLSDFGLAKLVGDANQFRMQTLCGTPNYLAPEVLIGAGQKAYSNVVDMWSLGVILFICLCGYPPFSEEITTHTLHEQITKGILNFIPEYWKNVSPDAVDLIKQLIQVDPSKRLTAAAALEHPWLQDEAVTARVDDLYRRVAARSVAPAAPVAEAVSRSKRPHEEDDAEDEANPVAVSKKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMZ8</accession>
    <name>A0A0D2WMZ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMZ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMZ8"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMZ8"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="379" mass="41277" checksum="1E82967336D07238" modified="2015-04-29" version="1">MLALLAVIITRPASFACLFALLSGFFGFLNYKVDFEQVTFSYAAVYERQQLSRIITAPFFHASLVHLLMNMSAVWTCSFFEEERGTLEYMRATALLIGLSAFVHLALTHCLVLHANWRGLVERRDSYRTCLSVGYSGVAFGLATLLGLAHPMYPVPFLFANFPAWSAPLFNLILTQFLVRRASLLAHVSGIIAGVFLHFGGLDVVSNFAVFCLAAQFVGGYMLEHDMWPFENLADGPAAVLDLPLQVNLIPSSVIAERLDRRHQLESVMVGAPAPHRPGLYDMSAAQSQSGFASQVSRGSSSNVRNTSFPLPAASLSSGQSTSLPVTPYRGGASTSSAPSAVSTAARPARDDELDPELSYPIDAPFRSFSPTHPHPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNP5</accession>
    <name>A0A0D2WNP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="9">PARP</shortName>
            <ecNumber evidence="9">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003714</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="9"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363442.1">
        <property type="nucleotide sequence ID" value="XM_004363385.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNP5"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNP5"/>
    <dbReference type="OMA" id="THEVILM"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031273">
        <property type="entry name" value="PARP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530:SF1">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="13">
        <location>
            <begin position="464"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="15">
        <location>
            <begin position="812"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1764"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1912"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2164"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1764"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1970"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2004"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2045"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2059"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2092"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="2177"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2188"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2242"/>
            <end position="2256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2491" mass="264495" checksum="AF2D49BB0D4F6D49" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQC8</accession>
    <name>A0A0D2WQC8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_004577</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAP-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347324.1">
        <property type="nucleotide sequence ID" value="XM_004347274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQC8"/>
    <dbReference type="STRING" id="595528.A0A0D2WQC8"/>
    <dbReference type="eggNOG" id="KOG4088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQC8"/>
    <dbReference type="OMA" id="QCSNNPK"/>
    <dbReference type="OrthoDB" id="10055808at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQC8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254685" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE93850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="18530" checksum="F54C42123D799815" modified="2015-04-29" version="1">MIKSVLTFVCFAAFLALASASELCDKPVVTDVSYTTTQLATSTKAVFISQFQIKCNDEFVDRANLHAVVDGEVLPVAVTGDNQEDSTYQVSWVREHDQVSAKTYTVQLYDSESFSAYSRAVRANEAVPAADFSVKVHHSGASKDGLFVPLEAVAVVAAIALAIFAQSKKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQF2</accession>
    <name>A0A0D2WQF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363678.2">
        <property type="nucleotide sequence ID" value="XM_004363621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQF2"/>
    <dbReference type="SMR" id="A0A0D2WQF2"/>
    <dbReference type="STRING" id="595528.A0A0D2WQF2"/>
    <dbReference type="eggNOG" id="KOG0905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQF2"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="7">
        <location>
            <begin position="454"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="591"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80093" checksum="5C2B1E2B53952106" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQJ8</accession>
    <name>A0A0D2WQJ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347421.1">
        <property type="nucleotide sequence ID" value="XM_004347371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQJ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WQJ8"/>
    <dbReference type="eggNOG" id="ENOG502TGHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQJ8"/>
    <dbReference type="OMA" id="HEEIDGK"/>
    <dbReference type="OrthoDB" id="1925570at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36074">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36074:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="215" mass="23713" checksum="32F7C65B06FEDA61" modified="2015-04-29" version="1">MASLLIQLNPNNKYHFEEYRVPSFVFHRTTLMISSIKATLAVAPLALQRNPDNSPKVNPRAIPSIWARTVLRELCVISTKTCLQRLVLNVCTLQTASHFMKSLPASAVRKVARYDSKLIGSLKVARAGLAAHLLTHLALFVVEEVIDLYTYYRSLKENGDDQNAKEKFINKTDKNLVRLIGSVALGALGSAIGTLIKPDLGTRIGGLIGDTILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQS1</accession>
    <name>A0A0D2WQS1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347516.2">
        <property type="nucleotide sequence ID" value="XM_004347466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQS1"/>
    <dbReference type="STRING" id="595528.A0A0D2WQS1"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQS1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQS1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="437"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="583"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="437"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="667" mass="75575" checksum="9AA1A5C980FED0B5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQU0</accession>
    <name>A0A0D2WQU0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348051.1">
        <property type="nucleotide sequence ID" value="XM_004348001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQU0"/>
    <dbReference type="STRING" id="595528.A0A0D2WQU0"/>
    <dbReference type="InParanoid" id="A0A0D2WQU0"/>
    <dbReference type="OrthoDB" id="63379at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055336">
        <property type="entry name" value="At4g00755-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39741">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39741:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="65856" checksum="2E793C25B839F4BF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR96</accession>
    <name>A0A0D2WR96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR96"/>
    <dbReference type="STRING" id="595528.A0A0D2WR96"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR96"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="862" mass="92029" checksum="0788BCD7D20CE5EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRD4</accession>
    <name>A0A0D2WRD4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_009817</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRD4"/>
    <dbReference type="InParanoid" id="A0A0D2WRD4"/>
    <dbReference type="OrthoDB" id="415724at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="168"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="579"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="880"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="1390"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="2243"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1937"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="927"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="978"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE94445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2485" mass="277065" checksum="AE8866368CFDF375" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRK1</accession>
    <name>A0A0D2WRK1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347358.1">
        <property type="nucleotide sequence ID" value="XM_004347308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRK1"/>
    <dbReference type="STRING" id="595528.A0A0D2WRK1"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRK1"/>
    <dbReference type="OMA" id="ENHRARG"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11790">
        <property type="entry name" value="SH3_Amphiphysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF3">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="410"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="51247" checksum="97842017EDB9BCEE" modified="2015-04-29" version="1">MSGKDFLSTLAKNAGRAQERVMQKLGKADETVDEVFQTHVKNFTKQLAVATRLQKDARSLMQAIQAMSNATKSLADSMVEAFDDGWSGATEFQEQAAIMVRSCHQFQQHAGELLSQSMNGYVNGQFPDLKNRIAKRDRKLIDYDRYRHALQGIKAKSKASDSKLTQAEEEHAQAKEIYEELNAQLNNDLPVFYEARIPFYKGVCHELYSAMFSFHETSTVTSCKLHQISAERSDISPAAAAIENLPSSIPNVAGLSGSTGFLGTASSTSPSHTTTSSSAVSQSASTGSANAAPAPVLSPAGKAPSTSNLHSSSSMGDVSGNSPSSGRGSTASGTAAAAAAATANAGNRKLSAANDDDAEITKRLEDLAVEFSGDSEPSSEPAPVLPPTAASVAAPAASSPATAKKKQGPKVLYTVRATHHYDGMEDDELTFGKGDIIMIVDTPPELELDEGWAYGVRQDGKKGVLPVNFTERLERTSKAYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRX7</accession>
    <name>A0A0D2WRX7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRX7"/>
    <dbReference type="InParanoid" id="A0A0D2WRX7"/>
    <dbReference type="OrthoDB" id="2429079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="909" mass="98343" checksum="F49522A116928C2C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS81</accession>
    <name>A0A0D2WS81_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347668.1">
        <property type="nucleotide sequence ID" value="XM_004347618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS81"/>
    <dbReference type="STRING" id="595528.A0A0D2WS81"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS81"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254751" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="59221" checksum="DC5DCE7299DF82B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSP6</accession>
    <name>A0A0D2WSP6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346826.2">
        <property type="nucleotide sequence ID" value="XM_004346776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSP6"/>
    <dbReference type="STRING" id="595528.A0A0D2WSP6"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSP6"/>
    <dbReference type="OrthoDB" id="6089360at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSP6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="523" mass="55717" checksum="66091347E2B2EC5A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT84</accession>
    <name>A0A0D2WT84_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346069.2">
        <property type="nucleotide sequence ID" value="XM_004346019.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT84"/>
    <dbReference type="STRING" id="595528.A0A0D2WT84"/>
    <dbReference type="ESTHER" id="9euka-e9cba6">
        <property type="family name" value="Carb_B_Root"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT84"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT84"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270175" evidence="1">
        <location>
            <begin position="32"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="36"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="590" mass="64678" checksum="CF7CF33F4911869B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT96</accession>
    <name>A0A0D2WT96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346087.2">
        <property type="nucleotide sequence ID" value="XM_004346037.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT96"/>
    <dbReference type="InParanoid" id="A0A0D2WT96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF23">
        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254650" description="Rhodopsin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19283" checksum="95D2F5D3B74C8594" modified="2015-04-29" version="1">MQLLSLLLALVAMPMLVSAYDSCGAGYYCSSPYYCCSPYPYSCCTSVAGLWYFWVAMVVGVAIFACFIICVVRRRRASYIATTYVAPVQQPAGTVVTTSTAYPAQGGYPPQGYPPQGYQQGYPPQQGYPPQQGYPPQQGYPPQGGYPPQQGTYPPQNYYGTPAPPSYEAELAKSSAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTB8</accession>
    <name>A0A0D2WTB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345664.2">
        <property type="nucleotide sequence ID" value="XM_004345614.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTB8"/>
    <dbReference type="STRING" id="595528.A0A0D2WTB8"/>
    <dbReference type="InParanoid" id="A0A0D2WTB8"/>
    <dbReference type="OrthoDB" id="437693at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="346" mass="37728" checksum="A0990C140DC4F828" modified="2015-04-29" version="1">MATPSSAFITAFRQFQLPAAMLPVFYSEAYNMGFGGIEKVLSPHPFDATKYRGVFKHLRAGPLASAFAPARIMAPPAVASDQDLLIAHSEEYLRSLKSSTTVAHIAEVITLAVLPIFMVNYGIVTPQRTMTSGTAFAAKAAMQAGWAINVGGGFHHASCNEGGGFCIFADISFAIKLLMREGLQRAMIVDLDAHQGNGHENDFAQDKDRVYILDVYNRDIYPGDRKAKSGMSLNVPVSSGIADAEYLQTVNESLDQALAQFSPDLIVYNAGTDCLIHDSLGRMAVSEQGILDRDEAVFRRALSRNIPIVMVLSGGYQSSNSRVIARSIENMVEKFDLLSRPWLVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTX8</accession>
    <name>A0A0D2WTX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTX8"/>
    <dbReference type="STRING" id="595528.A0A0D2WTX8"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTX8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="656"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="856" mass="92542" checksum="75032F24B75FED00" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU90</accession>
    <name>A0A0D2WU90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345280.1">
        <property type="nucleotide sequence ID" value="XM_004345230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU90"/>
    <dbReference type="STRING" id="595528.A0A0D2WU90"/>
    <dbReference type="InParanoid" id="A0A0D2WU90"/>
    <dbReference type="OMA" id="WPLEESA"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU90"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="868"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128249" checksum="3C8213153E28E6E0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUM5</accession>
    <name>A0A0D2WUM5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345705.2">
        <property type="nucleotide sequence ID" value="XM_004345655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUM5"/>
    <dbReference type="InParanoid" id="A0A0D2WUM5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="279" mass="30713" checksum="6694F2C103193329" modified="2015-04-29" version="1">MAEPSHLTDPLWPDVDPKAEKSAQFVLQDHQHLHRLCMNSLPSPFKLMESDYVETSPGSGVLQHYANGSSKTVGFSVVVPHPTNDRISPFWRLMRKASCCFVAQEQQFAQTKLGFSRSLDENWLAGGIVHYVVHPTVADMTIAEFQADIGGSSTVSGKTMDAMTIAAAPNCIKPVLAALRTHVSQCANVDPTRALVSSMVHDNLALRQFSLDDAMKHEDLCWYLYCATLQTTFSLGALHFLAQVNDFLVECAEEFGFPSAEVKTDKPSHPASSEPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUQ4</accession>
    <name>A0A0D2WUQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUQ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WUQ4"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUQ4"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUQ4"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="7">
        <location>
            <begin position="318"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="605" mass="66837" checksum="336940287F1684E2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUS2</accession>
    <name>A0A0D2WUS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUS2"/>
    <dbReference type="InParanoid" id="A0A0D2WUS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="14806" checksum="2920CCD3F1135036" modified="2015-04-29" version="1">MVKQNKQTASSSADALSTGLAGRSVNDAARAADAARALAAARAAAYARRDAAAPVPARGAARAPPAARVAAFGRAPPVGVEATSSSAPAPDAAPIELAQIAMVIDLQTQLIQDKERMIQDKNKMIEDMEKTIQGKNKMIEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV76</accession>
    <name>A0A0D2WV76_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WV76"/>
    <dbReference type="eggNOG" id="KOG1883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV76"/>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV76"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1676"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1871"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1686"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1871"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1919"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1930" mass="211333" checksum="98507FD0A8EAD453" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVB9</accession>
    <name>A0A0D2WVB9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343774.1">
        <property type="nucleotide sequence ID" value="XM_004343724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVB9"/>
    <dbReference type="STRING" id="595528.A0A0D2WVB9"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVB9"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="5">
        <location>
            <begin position="185"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1257" mass="133893" checksum="AD9ADC98502A15AA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW80</accession>
    <name>A0A0D2WW80_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343523.1">
        <property type="nucleotide sequence ID" value="XM_004343473.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW80"/>
    <dbReference type="STRING" id="595528.A0A0D2WW80"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW80"/>
    <dbReference type="OMA" id="TKASHGM"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="709" mass="75978" checksum="9C9A919CACD0A0F5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWH5</accession>
    <name>A0A0D2WWH5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWH5"/>
    <dbReference type="InParanoid" id="A0A0D2WWH5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="365" mass="40593" checksum="6D46832A56B2577B" modified="2015-04-29" version="1">MDSPARAKVLHIMGHSAQLGCNYCPRKAGPCECGHHRNWGNLTATQYANYDYIDHSQRKPGGGASCLRGLTNFPANGHVERSMCSLDTLHSVLLGSCKRLLSNTINKILTDPRAKQKKLAKLDSSLKETTWPSFAMRVPRKVSTQHGLYTGEEILNFVLVCARWIFADIAGLPGYHLMWLDMADIVFICVTKAIDISRIPTIELVIQRYIESATAANGPCGMPITTHHLTHIAWACRQHGPPAHVSTMVFERKVNELCRKIPPGTQNDILTRFVNKVVNDPPSQRSSTAGCGTGFRLRSKETGFKSVSDDLKNYYPPKKFVKNAIPPCSTPPPARFHAHMFEHMRCYTRTAVSPKEMTLSHCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWK5</accession>
    <name>A0A0D2WWK5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0598 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343890.1">
        <property type="nucleotide sequence ID" value="XM_004343840.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWK5"/>
    <dbReference type="STRING" id="595528.A0A0D2WWK5"/>
    <dbReference type="eggNOG" id="ENOG502R8EE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWK5"/>
    <dbReference type="OrthoDB" id="10260024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWK5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028108">
        <property type="entry name" value="DUF4505"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449:SF3">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14956">
        <property type="entry name" value="DUF4505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="33283" checksum="42F8AE1DDA7EB9E4" modified="2015-04-29" version="1">MLTRVASALTTRGFLQRLSRVHQNAAATTTAPSSQSSAAAWPRLTCVQSAAATSAPRPPTATIARAFTTSLVTLRSDANAGSGSPPTNSAGYLDPATTNSTSANDKHKSPLSPSSLVGSNSNSSYPYEQGAKPPPVAGESESKFTRQYFYFVDHHGQLFLDDVKIKNFVTCFKDKVFLDFFFRRLRRNTTGLYTEVFPYVSMCGREVNFVRVEDRPIVFHSITDDDKLLYGGKLAVDFHPEQIVMSAETARIYHPAPFETPGLLRSALCIELGKSVVFDSETTAILTYKDRPVQIRVVPHDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWR8</accession>
    <name>A0A0D2WWR8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWR8"/>
    <dbReference type="InParanoid" id="A0A0D2WWR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="224" mass="26099" checksum="E616015D0F0DEFA7" modified="2015-04-29" version="1">MLLCFWHQLAMGIHFPRTDAPTRETEAEVAAFRLQQRQFMGVQQHGFRHPRQPHRGPSQPLSGAETGTESSGAGSGARPAPFNGTSQFMRHMELRRRTQRMTASSDDDDDEDDDEEEDDNDRHLDWYTLRRNNETDSAADTEDVLGTASHYRRRARRMIARARSIATTAIDDEEARQAEQQARLLRLVQMYNRPWMLRRQNSRGSSQPLKYYDYFCYDYSGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ1</accession>
    <name>A0A0D2WWZ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2 5">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="2 5"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343505.2">
        <property type="nucleotide sequence ID" value="XM_004343455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ1"/>
    <dbReference type="FunCoup" id="A0A0D2WWZ1">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWZ1"/>
    <dbReference type="InParanoid" id="A0A0D2WWZ1"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="457" mass="51579" checksum="EEFCEA34BA409833" modified="2015-04-29" version="1">MLQEATVQLDSFKGLFRRFLQEGAQTIQWDKIKPPAANMARSIVLPYASLDKPNDHDIKGLLDQLVVIKLNGGLGTTMGCVGPKSVIDVRDDMTFLDMTVRQIEYLNNRYHTNVPLILMNSFNTHEETDHVIQKYHGSTVTILTFNQSKFPRISKDTLLPVAKNYLDHEAWYPPGHGDIYESLVAAPFFESLLLQGRQYAFISNVDNLGATVDTSILNYLINQAPKCEFLMEVTDKTRADIKGGTLIDYEGKTRLLEIAQVPKQHIDDFKSVTKFRIFNTNNLWIKMSAIKKVVTNKELELEIIVNHKNMESGVNVIQLETAVGSAMKHFENAIGINVPRSRFLPVKNTSDLFLVKSNLYHQEKGTLVMNPKRLFEVPLVKLGDEFRVVSKFLARFATIPDILELDHLTVTGDVTFGRHVSLKGTVIMCHHGDRIDIPVGAVLENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ4</accession>
    <name>A0A0D2WWZ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-tetrakisphosphate 1-kinase</fullName>
            <ecNumber evidence="8">2.7.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57539"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.134"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 10">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ITPK1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.134" evidence="8"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343514.1">
        <property type="nucleotide sequence ID" value="XM_004343464.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WWZ4"/>
    <dbReference type="eggNOG" id="ENOG502QQS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWZ4"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038186">
        <property type="entry name" value="ITPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol-tetrakisphosphate 1-kinase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="137"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="35870" checksum="5FD9405989FEAF65" modified="2015-04-29" version="1">MIKIGWWLSEAKQRKFDWPAVLDAFAAHKISQVKLDAKTTTVEEFQSLDCILHRAYGPDPSAVEMREWLQQMLAAPGCPAIPVIDPIEAADSLLHRERYFARLSEAIENHHPGTCQWTIPNSATIKTAGTPKADNVDALRVQLASSHVKLPVVCKFVGLTTDAHQMAIASTVAGLAEFVAEAPVGSTIVAQQFVNHGGVLHKIFVIGSAVHDVQRKSIRDLSDKDTETGLVRFDSSTISKATSTSPLHQAAAAAATTTATTTARSISVNTLQRLAQEVGDCLQLSLFGIDVVIDSDTGENVVIDVNYFPGYVGMPNVPEHVVRLVEARCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY79</accession>
    <name>A0A0D2WY79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="10">CPR</shortName>
            <shortName evidence="10">P450R</shortName>
            <ecNumber evidence="10 11">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="10">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="10 11"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343008.1">
        <property type="nucleotide sequence ID" value="XM_004342958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY79"/>
    <dbReference type="FunCoup" id="A0A0D2WY79">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY79"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY79"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="1 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="110"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="485"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="503"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="628"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="634"/>
            <end position="638"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="709" mass="78594" checksum="75B406063F58712D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYE7</accession>
    <name>A0A0D2WYE7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342605.1">
        <property type="nucleotide sequence ID" value="XM_004342556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYE7"/>
    <dbReference type="STRING" id="595528.A0A0D2WYE7"/>
    <dbReference type="eggNOG" id="ENOG502R5I5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYE7"/>
    <dbReference type="OMA" id="NFLGHAR"/>
    <dbReference type="OrthoDB" id="2340858at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="685" mass="77800" checksum="E70E2B7DDB5E5B5B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYG8</accession>
    <name>A0A0D2WYG8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342643.1">
        <property type="nucleotide sequence ID" value="XM_004342594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYG8"/>
    <dbReference type="STRING" id="595528.A0A0D2WYG8"/>
    <dbReference type="InParanoid" id="A0A0D2WYG8"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYG8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="107" mass="12676" checksum="939D47AF30F4933E" modified="2015-04-29" version="1">MATRFTTYEHPTFDTSSVDWTDPVSVAEGKERFVRERLILTEVTAIFREQTSACYRREGVNHLENCKDVVEAYQRHLDRYSNPRKPLDNPFRRITELRLQQQAAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYR0</accession>
    <name>A0A0D2WYR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342768.2">
        <property type="nucleotide sequence ID" value="XM_004342719.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYR0"/>
    <dbReference type="FunCoup" id="A0A0D2WYR0">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYR0"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYR0"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="411" mass="46281" checksum="60B0C4163BD26C1C" modified="2015-04-29" version="1">MTARIVEKAGVAASVASAASADDAGVRARKTAAAVAAAAAPASSERACKDSTVGSSESDDMSHRLKRFQHNAPTANPSPADLTDGYGAALHKTDFHWVGTDEPHASRRKLILAKYPHIRDLYGYDHKTVWITLGLVTLQLTMAYLLRNSSVWFILPFAWAISGSSNSCLNMVVHECAHGLALKYRPYNAVLGMIANIPTCVPSSITFRRYHLDHHTSQGVDGVDVDLPTDLEGKYVRGRFLKALWLFFVPLFYTLRPMFVKPRSPILAENINQAFIITIDVLIYHFWGWRSLFYLFGGLWLGSSYHPSAAHFIAEHFEFAAGAETYSYYGPLNNIMLNVGYHNEHHDFPYVPWTRLHKIREAAPEFYSDLPQCRSWVRCIWDFVFDPKITLYSRVKREARQKQLLAELAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYS1</accession>
    <name>A0A0D2WYS1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">20S proteasome alpha6 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342791.2">
        <property type="nucleotide sequence ID" value="XM_004342742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYS1"/>
    <dbReference type="FunCoup" id="A0A0D2WYS1">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYS1"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYS1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYS1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="340" mass="36898" checksum="3E5ECB7963E3AA12" modified="2015-04-29" version="1">MEYGCRVIDEHSTIAICNSAEILRIDQAVFFFFPLFPALPVLAPVMFRNQYDNDITTWSPQGRIHQIEYAMEAVKQGSCAVGLKSKQYAVIVALKRSSSELSAHQRKIFKLDDHVGIAISGLTSDARVLSKFMRNECLNSRYVFEAPLPVSRLISSVGDKTQVCTQRAGRRPYGVGLLVAGFDESGTHIYQTCPSSNYYDCKAMSIGARSQSAKTYLERHFEEFTDADKDTLIRHGLTALRDSLPSNTKLSQKNCSVGIVGFDTAFTILEEDALSPYLSVLDEASSSSSGRGGAGSGNAAAMVTDEPAAGAGEPEVTPAEAMPSADDSQPPQSEAMETDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D7</accession>
    <name>A0A0D2X0D7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap guanine nucleotide exchange factor GEF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0D7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0D7"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0D7"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0D7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="318"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="484"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="718"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="857"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1126" mass="124870" checksum="3FE3451C5FAEBAB5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F8</accession>
    <name>A0A0D2X0F8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365419.2">
        <property type="nucleotide sequence ID" value="XM_004365362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F8"/>
    <dbReference type="STRING" id="595528.A0A0D2X0F8"/>
    <dbReference type="eggNOG" id="ENOG502QT3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0F8"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF11">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="79256" checksum="33EE78507335CA46" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0R6</accession>
    <name>A0A0D2X0R6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-acylethanolamine-hydrolyzing acid amidase</fullName>
            <ecNumber evidence="8">3.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365846.1">
        <property type="nucleotide sequence ID" value="XM_004365789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0R6"/>
    <dbReference type="STRING" id="595528.A0A0D2X0R6"/>
    <dbReference type="MEROPS" id="C89.002"/>
    <dbReference type="eggNOG" id="ENOG502QT7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0R6"/>
    <dbReference type="OMA" id="GQDHINM"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0R6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047412">
        <property type="term" value="F:N-(long-chain-acyl)ethanolamine deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF4">
        <property type="entry name" value="N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270313" description="N-acylethanolamine-hydrolyzing acid amidase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="12">
        <location>
            <begin position="128"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="364" mass="40161" checksum="F02B67A70D2A0B25" modified="2015-04-29" version="1">MRQSGLNVSVAALLLLQLVLLLTVGALAQQHDFPPEQVIVNLDLPPKQRWTQVATKYSAQIQATVNFLKQLIPMHDLVLPVANVIGADIDNYLPMPYSDEIRGVAEAARITLGEAVLCNIIYDITSFCTSIVAQMGNGTIIHARNLDYGPLQGVLRNMTIEVFFQTNGSTLFYGTTFAGYTGILTGVRPNVFGVTINERDMGNILENALQALLKKEAVPLSFMLRDALANDTVTFESAVRFYSRTQLIAPVYVIVSGTQPGEGVVITRDRQYILDIWRLDPAAQSWYVVETNSDNWNPGQDIRLETAHKSLDALGPNGINPYSIYQVLSTAPVLNNGTVYTTVMSASHPEWFSTMVRLDIPPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0S8</accession>
    <name>A0A0D2X0S8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365899.2">
        <property type="nucleotide sequence ID" value="XM_004365842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0S8"/>
    <dbReference type="STRING" id="595528.A0A0D2X0S8"/>
    <dbReference type="eggNOG" id="KOG4362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0S8"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0S8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17736">
        <property type="entry name" value="BRCT_microcephalin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17751">
        <property type="entry name" value="BRCT_microcephalin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="567"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="647"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="738" mass="77751" checksum="26DC95DFA20720F9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Y6</accession>
    <name>A0A0D2X0Y6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0Y6"/>
    <dbReference type="STRING" id="595528.A0A0D2X0Y6"/>
    <dbReference type="InParanoid" id="A0A0D2X0Y6"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0Y6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27088" checksum="FCCC589780EE6C3F" modified="2015-04-29" version="1">MAALSASLRHLSLQCCISITDDMLSVLHGLANLKTLSLAQCTVTDRGVIPLLGAIGAHLEELYIDELAIGPMTNETVANIATHAPELKQINLTRCGTLSDLGVGQLVLHCPRLRVLSLNSLNNLTPALFACIAHDRELFDQAIEATRLHHAQLPVRRNPTTGVVIVDPLPEPTAFSAQALTDLQVLDVSWCRSMDDPSFAAIVRSCEQLSRIEIFGCNRLTECIRSLKPASQLRIVGAPFEIAELGGVSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X137</accession>
    <name>A0A0D2X137_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364346.1">
        <property type="nucleotide sequence ID" value="XM_004364289.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X137"/>
    <dbReference type="FunCoup" id="A0A0D2X137">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X137"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X137"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X137"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="396"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="738" mass="83326" checksum="E0FE797827F84203" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X187</accession>
    <name>A0A0D2X187_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_001698</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X187"/>
    <dbReference type="STRING" id="595528.A0A0D2X187"/>
    <dbReference type="eggNOG" id="KOG4437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X187"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X187"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000003">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="396"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="683"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="965"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="688"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1113"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE90379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126541" checksum="73CFAE1880F2D420" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Z0</accession>
    <name>A0A0D2X2Z0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348012.1">
        <property type="nucleotide sequence ID" value="XM_004347962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Z0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Z0"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Z0"/>
    <dbReference type="OMA" id="WVGRSAF"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Z0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="65390" checksum="89B0B449DFB86454" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X359</accession>
    <name>A0A0D2X359_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ste24 endopeptidase</fullName>
            <ecNumber evidence="1">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348317.1">
        <property type="nucleotide sequence ID" value="XM_004348267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X359"/>
    <dbReference type="FunCoup" id="A0A0D2X359">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X359"/>
    <dbReference type="MEROPS" id="M48.003"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X359"/>
    <dbReference type="OMA" id="FALCYMW"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X359"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="13">
        <location>
            <begin position="60"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="12">
        <location>
            <begin position="247"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="59265" checksum="681E972821A0F47F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3M9</accession>
    <name>A0A0D2X3M9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3M9"/>
    <dbReference type="STRING" id="595528.A0A0D2X3M9"/>
    <dbReference type="InParanoid" id="A0A0D2X3M9"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="578"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="90229" checksum="0ABB2783726B03CE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X438</accession>
    <name>A0A0D2X438_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345427.1">
        <property type="nucleotide sequence ID" value="XM_004345377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X438"/>
    <dbReference type="InParanoid" id="A0A0D2X438"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X438"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="110" mass="11688" checksum="32259B8BFC8EDE08" modified="2015-04-29" version="1">MVQGKVKTTASGGITKAKNRPVKAVMKKGARNIPPKKTTLVQLQTMKKKLESGIKHNIEQTMIHRAATQSGHLSLVKREAGFKLPAKKDKAAAAAQNKTAAAAALHPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4L8</accession>
    <name>A0A0D2X4L8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Rca1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_006627</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4L8"/>
    <dbReference type="STRING" id="595528.A0A0D2X4L8"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4L8"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4L8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255502" evidence="17">
        <location>
            <begin position="19"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="611"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1019"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE96284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116057" checksum="997BFED710766238" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4V1</accession>
    <name>A0A0D2X4V1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4V1"/>
    <dbReference type="InParanoid" id="A0A0D2X4V1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4V1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46197" checksum="8197830C99703535" modified="2015-04-29" version="1">MLTYQSMSESQRKLYDKVTDTSEWLRLNDYEIGDVGAQVVAEALKVNTTVTHLKLRQNQIGDVGARAIAETLKVNKTVVEVILSWNQTGDAGAQAIAEALKVNTTLFSLNLSSTQLGDAGARAIAETLKVNTTLKYLYLSRNQIGDAGAQAIAEAVKVNTNLIWIRLNTNRIGDAGAQAIAAALGENKTTTELHLARNCIGKVGVQALDEARKVNGILTTLDIWDQINPLAFSLLPRLATSEDWQSVFHLLTGRHEKENQPALLPALPAEIAELVMDEAEYLQGVQHIHQAWAKDHYVDFLKLTMPRSSNGNSIRVKAIQVLREQYEAKSDPFEQYEAKSGRFDLIVRDELGAVRYEWAAEAPVVGSNIQLVTISPTDHPVIRQMRAGWEVEVQFGQYYSFVRLAWLSVGYIERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P8</accession>
    <name>A0A0D2X5P8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270886.1">
        <property type="nucleotide sequence ID" value="XM_011272584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5P8"/>
    <dbReference type="InParanoid" id="A0A0D2X5P8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42777" checksum="C8E959199D7F6CD2" modified="2015-04-29" version="1">MSHPDTQPLSSSYASGSSVGSPSNAYSSVGRAASMNGSNRGSGMWPARSSSSSFVYSEDSGRYPASGGSNVSFYQDGSRVATSSSYGSFGPRSGSDQAAALLIHPPTAESAPPPYSPAAGFAPIVISSNTPTIHQYEDGSSRCCERFVRFLLAPLHYHTWMVVFVILLASLPFTLVASVWCLVTLVLMVPLLCIFPIGAPAVTMLGYSWRALGRMATQLELFLYEKAGGRTQLSRVQAHLPTVEVRSTADGRNCWVDSFRSFKSVLGNRVTWASVMYLAFLRTLAVLVTVLAVVVCVMVPLALIFNFAVILVCDDDACWNALRPSEWGGMEDHRWIFTELRGSAVTAPVGLVLLIILTNLLLVIVRGFARIAFSLLVSPTEESVLLLSATQAPLPAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZQ6</accession>
    <name>A0A0D2TZQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>urea(in) = urea(out)</text>
            <dbReference type="Rhea" id="RHEA:32799"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364945.2">
        <property type="nucleotide sequence ID" value="XM_004364888.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2TZQ6"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZQ6"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464:SF4">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="896"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1419" mass="148911" checksum="E6AC134513AD5501" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U192</accession>
    <name>A0A0D2U192_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269997.1">
        <property type="nucleotide sequence ID" value="XM_011271695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U192"/>
    <dbReference type="InParanoid" id="A0A0D2U192"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="635" mass="68895" checksum="A23666274876FCA5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4W9</accession>
    <name>A0A0D2U4W9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 209</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364407.2">
        <property type="nucleotide sequence ID" value="XM_004364350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4W9"/>
    <dbReference type="STRING" id="595528.A0A0D2U4W9"/>
    <dbReference type="eggNOG" id="KOG4670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4W9"/>
    <dbReference type="OrthoDB" id="509821at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4W9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09786">
        <property type="entry name" value="CytochromB561_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="64807" checksum="A8E8BB61F45B4921" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8T4</accession>
    <name>A0A0D2U8T4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349360.1">
        <property type="nucleotide sequence ID" value="XM_004349310.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8T4"/>
    <dbReference type="InParanoid" id="A0A0D2U8T4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="483" mass="52225" checksum="BAC0400B028220F0" modified="2015-04-29" version="1">MTETLTSADMLFDQTQLLNEPTTPVRNARIHTMQEDFQDQHRPPTPLSRTRRASFSAPAVLRINDANDYLISLSMDKMSLQDETSGLRKSVLIQRVLSSRLQYKEHSGELSPSLRMRKESKRMSPLTPSSPFLFGAHAYSTTSFLPEYSDDPLASVFQLESRFSSEDKHDDSDGEDSADDSSSSCSDNDNDEDEEENEEENEENDANADRKRGSHVLVSPLFSRQSAANITRRSPATTITTTTTTVVDMTSATQADLANEERVIEMNLDDEDSQTARQQNAAGGSSESPTSSASSSATSSPDPEQGEQLLAKGPFAASSALADARANTVYDLSSHSLLGPAPTSVLEQDLSNADLPLYSIGGKGFYRESASSANSGSAAVAHELEAAALAMMNESAQADGMSVFDQALFDSLSGPEASTGDVTEHSVLHTAHNGKNILILRRPKRPFDQDAPEDATVELASDVVAASHPELKRVRSNLDTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBJ0</accession>
    <name>A0A0D2UBJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364222.1">
        <property type="nucleotide sequence ID" value="XM_004364165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBJ0"/>
    <dbReference type="STRING" id="595528.A0A0D2UBJ0"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBJ0"/>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340:SF1">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="68852" checksum="A82ECD58AB38D032" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHA7</accession>
    <name>A0A0D2UHA7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346815.1">
        <property type="nucleotide sequence ID" value="XM_004346765.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHA7"/>
    <dbReference type="eggNOG" id="ENOG502RA4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHA7"/>
    <dbReference type="OMA" id="MIRRIHM"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047803">
        <property type="entry name" value="DCD1A/B-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35190">
        <property type="entry name" value="PROTEIN DCD1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35190:SF2">
        <property type="entry name" value="PROTEIN DCD1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268544" evidence="1">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="446" mass="48906" checksum="CC574B9D27213559" modified="2015-04-29" version="1">MKLLLVVLVALLGCAAIPTAFGAYCNGKPNPDAQPNTLPITTSAPVLVRSITNAKLFIAGQGDDQFNILHVWGSPYEMGYAHGSILKEEASEFVLAVWAYLVGQADSAINGTAHNLRPWMVDLIANFGLDAALDLTFDATNPYTGSYFLDEMHGLADATGLDYKMIRRVHMIGELTKGGCSMYGAWGKATASTGKLFQMRALDWDVDGPFKDYPQITVYHPSNSDNGHAFANIGWTGWLGSITGFSSVQTAISEIGATYSDASFGSDSRFGVPFTFLLRDILQFDQTIDDALNRITNAHRTCSLILGVGDGKLNEFRSVQYSYSVANIFDDQNMQPYNETWHPRIENIVYYGMDWLCPNYDIVLARQLTKHYGNITAEVTINDILPIVQTGDLHIAVYDLTEQLVHVAVAKRSTGTGAPLAYNRAFTRLSMTALFQEPAPTAAEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ06</accession>
    <name>A0A0D2UJ06_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346259.1">
        <property type="nucleotide sequence ID" value="XM_004346209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ06"/>
    <dbReference type="FunCoup" id="A0A0D2UJ06">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJ06"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJ06"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJ06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="649"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114946" checksum="41B4D594A3DAA460" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK37</accession>
    <name>A0A0D2UK37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl peptidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345515.2">
        <property type="nucleotide sequence ID" value="XM_004345465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK37"/>
    <dbReference type="STRING" id="595528.A0A0D2UK37"/>
    <dbReference type="MEROPS" id="C01.070"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UK37"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UK37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018526353" description="Dipeptidyl peptidase 1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="11">
        <location>
            <begin position="255"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="493" mass="53722" checksum="AEBFB6CBAEB73B57" modified="2015-04-29" version="1">MRTASALLVALLALLGVAAVARADIPVHCLYDQIVGTWRFDMGANNGDNSLVCNDDTFNPVKSLHLRFAEPNIVYNSSGIQVADWTMIYDEGISVRMMDGAKFTQLFFAFFPYTVDPISGNVTSFCNETVLSTYHDAPYGSGQLPLGWGCFKGYKASYFTEQEAANTVSPVTTYAPKPQAASPDAIFHADHEYIARLNAAQNLWTAGPNPALVGRPMREVQAMAGRKLKTSVEAHLPPAKLRTAAKASADAFAAYPAELNWRNVSGIDYVGPMRDQLSCGSCYAFSGTEMLQARIRVKSQNKLTPLLSPQRVVSCSAYSQGCDGGFEYLVSKFGQDYGFVDESCFPYQSGLIPEVPCSAGCALPRLYTVDDFNYVGGYYGNCSELGMIDHLVNYGPLSVSFLVLDSFMTYRSGVYTCDTTPGTVGFNPFETVSHAVLLIGYGVDPTTNTKYWRVANSWGRHSTDYGGDFLIRRGTDECAIESAASWATPSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULM1</accession>
    <name>A0A0D2ULM1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biotin/lipoate A/B protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345126.2">
        <property type="nucleotide sequence ID" value="XM_004345076.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULM1"/>
    <dbReference type="FunCoup" id="A0A0D2ULM1">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2ULM1"/>
    <dbReference type="InParanoid" id="A0A0D2ULM1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="397" mass="41912" checksum="BED2137A4D69564D" modified="2015-04-29" version="1">MKRRHDDGNDDPSPSSASSSSSSAATGSNDAHRAAAGAAAGAAAAAGAIVLSKKPRTDLDLAVVPAASASSSALILHSQHPQLQQRPRLSTLLAPIVLLTGHSAEVTAARFNPAGTILASASLDKSVLLWDTASCKNFANFSGNHTAGILDLQWTSNGERIVTASIDKSVGIWDAANGDRIRRYKAHQGIVNACATALNNQNAIVSGSDDRTTRVWDPRVRAEVHSLACSYPVTSVAVSHGGDTVYAGGLDNVVKVFDLRKPSEPALVLEGHADTITSLSLSPNGNFVLTNAMDNTVRIWDVRPYCPNDRCSTILTGAQHSFEKTLLRANWSPDGNFVAAGSADRFVYVWNANTRALLYRLPGHSGSVNDVTFHPKEPIIASGASDKKIYLGELDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULU3</accession>
    <name>A0A0D2ULU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULU3"/>
    <dbReference type="eggNOG" id="ENOG502QTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULU3"/>
    <dbReference type="OMA" id="YKQHSNI"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF47">
        <property type="entry name" value="LIPOPOLYSACCHARIDE 1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42338" checksum="87010FFC38D5A67C" modified="2015-04-29" version="1">MDQQDRSAAEDSNQANGIVPEAARKEPINVMISSDAQTVMGVPTLIQSIFAQTPEPERVVFYIAVGSDTELLRLQRWISLSFWQYSESQFVLKVFPVEWVANKIKIRGRRTELASPANYARYYVLDLFPGISKRVIYLDTDVIVRGDIAEFYKFPLGPDKIAAFAQDCSRNKYKFFINFENAKVQALNIDPDTCSFNAGVYVTDLVRWKKHNITSELEYWMELNTRENVYGGQGSGGGSQPPVLLALFGHVVDLDPKWHVRHLGWHGSNSYQKEYVDEAKLLHWNGQGKPWLRKTVGVANFVHKWREFCVPEPPLADDACTLQAEGEIDAIYVSDQVLDPFDCASLREDYQTQLSDNIALDCKFPVEVPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNM7</accession>
    <name>A0A0D2UNM7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344500.1">
        <property type="nucleotide sequence ID" value="XM_004344450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNM7"/>
    <dbReference type="STRING" id="595528.A0A0D2UNM7"/>
    <dbReference type="eggNOG" id="KOG4090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNM7"/>
    <dbReference type="OMA" id="CDADARN"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNM7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="16156" checksum="5ADD3A654538BAEE" modified="2015-04-29" version="1">MPRRSAPAAKAAPVRTAAPAPARTAAPAPVAAAPHHPAPVQHHAPMPMQPQPQQPGLFAQMATTAAGVAVGSAVGHTIGHAVTGMFGGSSSSQPAAAEAAPAPVAQQAPMYNNNNNSQVCSYELQQFLDCIKTHDRDIGLCSGYSDVLKQCKVSYGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNV9</accession>
    <name>A0A0D2UNV9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Acetylglutamate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_006934</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344555.1">
        <property type="nucleotide sequence ID" value="XM_004344505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNV9"/>
    <dbReference type="FunCoup" id="A0A0D2UNV9">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UNV9"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNV9"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNV9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="17">
        <location>
            <begin position="378"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="701" mass="74156" checksum="CC314AA5DEDEE2D0" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP84</accession>
    <name>A0A0D2UP84_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343801.1">
        <property type="nucleotide sequence ID" value="XM_004343751.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UP84">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP84"/>
    <dbReference type="eggNOG" id="KOG1837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP84"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP84"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="2203"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1385"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1494"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1747"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1385"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1748"/>
            <end position="1772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2495" mass="264691" checksum="9C41A0D164D45FA7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQV7</accession>
    <name>A0A0D2UQV7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichome birefringence-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343133.1">
        <property type="nucleotide sequence ID" value="XM_004343083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQV7"/>
    <dbReference type="InParanoid" id="A0A0D2UQV7"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQV7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF48">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="450" mass="49461" checksum="88EB5F306EA7CCB1" modified="2015-04-29" version="1">MPLEAPRVKVLAVFACIVLIITWALVWSDSAIPPGTPEANHGADAGISLLPIALPQGVDHAAVVLSDPSTTGAAFASCIASATDSLAAEPSRSEPDRHQPPIGCARSKNSIATQAQSITQAPSPAEPALPTSQASSASPRGWYQLPADHPRVLARQAAADWNKTFDVYQPPDSWRCPYENETRWFWDTDTVAEIGVDWKTALTVALTNKTVGIHGDSLTLQTISVFLNLVESAGFELVKVKRITRFTGYFPALNFTLIANYVPYIVDMLGEKPYPQLSLDRLSQAFTIMADAADYMVINIGLHLMSNNYKFENSSWVDAYTHIIRVARDAASARQDRNPAARTFFRLTPPRHFQGGDYDSGGLCNDREPKWGATYSDFNLGEDQLLQNRIVSEEVARDPRLEILDVVPCTVERVDAHRGGNDCVHFCLPGGGPVRVWVEMLIRRLYDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQW2</accession>
    <name>A0A0D2UQW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQW2"/>
    <dbReference type="InParanoid" id="A0A0D2UQW2"/>
    <dbReference type="OrthoDB" id="10004529at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="42457" checksum="8B2735ABD189E1F1" modified="2015-04-29" version="1">MPTDLRQVLRRWGAPSTNSPIARRIRIVIVLLVVFGVFWWLLQMASSDRLHPIDQSEALFHAVYGTPMPSRDFKCYESSRFQYQLTAFAIFRDADKYLKEWIEFHRLVGFDHFLMYNNNSTDNFREVLVPYMRAGLVTLIDFPTILTHDISGYLIQNTQKVGIIDGVQRFRCLTRYMGIFDIDEFFFPTSPKQSLLTLMNTFVGSGKCGGVAAWRLNFGSNNHTTTPPGLVLEEYTRRSNEVITGKKVLFNPRQMAGLHNTHSLYFYDGKPLCDEKFRELEYTTFSDHEAKAIREVDVLRINHYYTKSYQDWDERLKRGTISGNNNDFGWKLFLEADNNEYLDTTVARYLPQLRQAMSAQNAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTB8</accession>
    <name>A0A0D2UTB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008222</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTB8"/>
    <dbReference type="FunCoup" id="A0A0D2UTB8">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UTB8"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTB8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002164">
        <property type="term" value="P:larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000181">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="46"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE98226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="415" mass="47047" checksum="05D0E0AD55EE168C" modified="2015-04-29" version="1">MFSDRLRRQTSLFCMPVFHFFNRFLTLLRMGGELVRNQTFEVAPRYKDLIYIGEGAYGMVASALDTTNNSRVAIKKISPFEHQTYCQRTLREIRILTSFHHENIIAIIDFIRAPSLEAFKDVYIVQELMETDLYKLLKTQTLSNDHICYFTYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARVADPTKDHAGLLTEYVATRWYRAPEIMLSSKAYTNSIDTWSVGCILAEMLGGRPLFPGKHYLNQLTLILNIVGTPASDDLDCIGNEKALAYIQSLPGKLKVPWESLFVSANPQALDLLDKLLTFNPTKRITIEDALAHPYLEQYYDPTDEPVAERPVNVDLESETCSKEVLKELMFQEMLNFHAARSGAPSGWLTNGALVFGVADISERLRAPVFSGCSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTI2</accession>
    <name>A0A0D2UTI2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346380">
        <property type="protein sequence ID" value="KJE98296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTI2"/>
    <dbReference type="InParanoid" id="A0A0D2UTI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268859" evidence="2">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="105" mass="10965" checksum="BCE1FDC6EE491AA8" modified="2015-04-29" version="1">MIMMMLAAIVLLAPTTVAGAAAAGDQTSDALQRPPSQSQSQSDPPSHPHGGRSRAIQYLSAESFEGLKQVAPFIVAVLTVSPASTLAAQSQLDARYQSTLRRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFX2</accession>
    <name>A0A0D2VFX2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365132.2">
        <property type="nucleotide sequence ID" value="XM_004365075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFX2"/>
    <dbReference type="STRING" id="595528.A0A0D2VFX2"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFX2"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFX2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="407"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65258" checksum="B7FD357293A571D9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHN3</accession>
    <name>A0A0D2VHN3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="8">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="8"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHN3"/>
    <dbReference type="FunCoup" id="A0A0D2VHN3">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VHN3"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHN3"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="872"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126724" checksum="0FFCCBC623D78722" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJY6</accession>
    <name>A0A0D2VJY6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJY6"/>
    <dbReference type="eggNOG" id="ENOG502S0WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJY6"/>
    <dbReference type="OMA" id="GRNIKNW"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJY6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="771" mass="85233" checksum="66CAC92AF094F929" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLA2</accession>
    <name>A0A0D2VLA2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348875.1">
        <property type="nucleotide sequence ID" value="XM_004348825.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLA2"/>
    <dbReference type="FunCoup" id="A0A0D2VLA2">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLA2"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLA2"/>
    <dbReference type="OMA" id="RECQSHS"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="446"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="658" mass="73168" checksum="D28BBEDB3E49D62A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLJ2</accession>
    <name>A0A0D2VLJ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLJ2"/>
    <dbReference type="InParanoid" id="A0A0D2VLJ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="123" mass="13676" checksum="35E2E9CFCF0F29E0" modified="2015-04-29" version="1">MRRLPSGCMGGRRKCPGSCTRRHQTARTGGCRVEPALPRKGRGRWDAGPRLVDGRGPFWDGRSVERRHLKARAARDPTVLAPKQRRRARGCTARLHARARLKPSGECAQTARAQPTRADGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM81</accession>
    <name>A0A0D2VM81_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VM81"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM81"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22248">
        <property type="entry name" value="Rcc_KIF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="118"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1476"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1752"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="964"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1036"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1247"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="714"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="841"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1107"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1310"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1793" mass="192355" checksum="75DC13D84251D515" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMZ9</accession>
    <name>A0A0D2VMZ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAMK/CAMKL/MARK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMZ9"/>
    <dbReference type="STRING" id="595528.A0A0D2VMZ9"/>
    <dbReference type="InParanoid" id="A0A0D2VMZ9"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="142"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="725" mass="80012" checksum="0B2EB4377E1E03B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP83</accession>
    <name>A0A0D2VP83_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP83"/>
    <dbReference type="FunCoup" id="A0A0D2VP83">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VP83"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP83"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253764" description="hydroxyacylglutathione hydrolase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="108"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="389" mass="41617" checksum="CE05751335D65892" modified="2015-04-29" version="1">MLVSRIASACPSRIAAFVTLVAALAPTFSSPVRTLTAHSSHPLCFAQAQHHLQARSFHPSSAASPPATTPGSSSSSTAAARLPSHSHQTQSSHFANTMQIHTVPILEDNYSYIIVDPSSHAVAVVDPAEPEKVIHALKQLPKSDALNLVAVINTHHHWDHAGENVKFLELAATELNAQGVNVYGGDDRVPKLTHKVTHGETFTLGSIKFTALATPCHTTGSISFRAQSPDGAVDRVVSDESHKPGKWSYVETDVVFTGDTLFVAGCGKFFEGSAANMHHSLIDVLGALPETTRVYCGHEYTVSNLYFAQSVDGANSEVTRALTDAQALRAKGLPTVPSSIGRELAINPFMRVRDPAFCEARAKLAGVASDAITIMGELREAKNRFKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP90</accession>
    <name>A0A0D2VP90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270290.1">
        <property type="nucleotide sequence ID" value="XM_011271988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP90"/>
    <dbReference type="InParanoid" id="A0A0D2VP90"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP90"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025475">
        <property type="entry name" value="DUF4326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14216">
        <property type="entry name" value="DUF4326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4326" evidence="2">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="258" mass="26649" checksum="750827E887BCD2E5" modified="2015-04-29" version="1">MQVSRKPRSQNRPANPPAAAVNSPAAAVNPPAVAAAPAPAHPAAAPVLPVAAQTSSSATAPQRTAGAWSSPKSFAQIVGASQSTPPAPKEHQQPSAAPQKNSRDALTSSPATTNAATASTSAAAASSSGNNATLASSSASPSASPTTTKKLQIVNLKRGMGTIGTATYPTIETWLADPSNAYVGRKTYVTPHTPFGNPFKVNHEGERARRIEMYREHLLTTPGLLELAKAELRGKNLGCWCHPLACHSDVLMELVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPC0</accession>
    <name>A0A0D2VPC0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPC0"/>
    <dbReference type="STRING" id="595528.A0A0D2VPC0"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPC0"/>
    <dbReference type="OMA" id="QGEWHVE"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="17799" checksum="3139326FF560B74E" modified="2015-04-29" version="1">MSDSKGILFVCFGNICRSPMAEALCAHLLRASEQVEQTASASTQPHSRSLRWFVGSAATSDWNDGQQPDPRTFKICRHHGVFLSHVCRQVVEDDFDHYDFILAMDRENYKYLQTMKAGSSKGARLELLGDYDPKGVREILDPAMNKTLKMCISTYCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPI6</accession>
    <name>A0A0D2VPI6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364219.2">
        <property type="nucleotide sequence ID" value="XM_004364162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPI6"/>
    <dbReference type="FunCoup" id="A0A0D2VPI6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SFDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPI6"/>
    <dbReference type="OrthoDB" id="6432863at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPI6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="193" mass="22012" checksum="452A24C8F19D856F" modified="2015-04-29" version="1">MSVTFQTTGELMREATRVFTQGDDVREVSEIMQLQRQVSDIHEQRELASKAAILELTAKLSAEESKCVRATPDNQHAEVLQNIENDKFALAKSINHLDRDNQALTSTMHKLDGDLDAIQARRQAVEQARTVGVPQNKSIVSLYMNITNIKWDFEQDNLVKGFVTKNNDVRPFSLDPKVQTPYFIANYLWEKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPL3</accession>
    <name>A0A0D2VPL3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPL3"/>
    <dbReference type="eggNOG" id="KOG2037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPL3"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPL3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266078" description="Guanylate-binding protein N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="41"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="5">
        <location>
            <begin position="84"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="934" mass="103313" checksum="5F092701363BB4FE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRE1</accession>
    <name>A0A0D2VRE1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin modifying protein 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348045.2">
        <property type="nucleotide sequence ID" value="XM_004347995.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRE1"/>
    <dbReference type="FunCoup" id="A0A0D2VRE1">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRE1"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRE1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="25155" checksum="5677750F50B5C26D" modified="2015-04-29" version="1">MSSIMESLFGSRKTPAQMLRQHQRSLTKAMRDLDRERSKLEQQEKKIVTDIKKMAKEGQMDAAKIMAKDLVRTRRYVKKFIMMRAQIQAVSLKIQTLRSNQAMAEAMKGVTRAMTKMNKQMNLPEIQKIMMEFEKQSEIMDMKEEMMNDTIDDVMGDADDDEESDQIVNQVLDEIGISLGQSMVDAPITATGGGGGKVTEAKTAVADSADADLQARLDNLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRH3</accession>
    <name>A0A0D2VRH3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_004255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348080.1">
        <property type="nucleotide sequence ID" value="XM_004348030.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRH3"/>
    <dbReference type="FunCoup" id="A0A0D2VRH3">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRH3"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRH3"/>
    <dbReference type="OMA" id="MCHDHFY"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="158"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="344"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1193" mass="134488" checksum="8D38115D1B597EB2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTN8</accession>
    <name>A0A0D2VTN8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Voltage-dependent potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_005253</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTN8"/>
    <dbReference type="STRING" id="595528.A0A0D2VTN8"/>
    <dbReference type="eggNOG" id="KOG3713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTN8"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTN8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000097">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000091">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="220"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="578" mass="62398" checksum="58809944CAF60A02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV68</accession>
    <name>A0A0D2VV68_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV68"/>
    <dbReference type="InParanoid" id="A0A0D2VV68"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV68"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="863" mass="94198" checksum="C267F579130117D0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVM5</accession>
    <name>A0A0D2VVM5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVM5"/>
    <dbReference type="InParanoid" id="A0A0D2VVM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="100" mass="11102" checksum="97440903ECB3A5B1" modified="2015-04-29" version="1">MRKRATARSALPDFRHCALQIVFCKVEDENHLLESRVGLDCECVAPELMEAWACLEFLVFAAREGVLLRAIEDEASEVRNSVGRVDGCEVEAGAAPQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW15</accession>
    <name>A0A0D2VW15_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW15"/>
    <dbReference type="InParanoid" id="A0A0D2VW15"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="306" mass="33380" checksum="F698367D0EDEA2BE" modified="2015-04-29" version="1">MAHPALKSLKVFDVARLAAHPFTARAATKLVAAQSEIVARAQKVPAETKPSIDFDHYKSILDRFDPHLVATAKAEYDRFQATPSTTKITIDGQATWDQDAASLVADSKKDIATIDAKLKQIAELKPVEEMTHADLYEMSPRHFERTVAMLREYYPSYMKKEHGEVSDEAKTYARSFVPKLPVENQEQIATDVAVAPVEPTEVKERVTEKRSQDETIESDKIVETAATNDAVTEAPASPATKVVRLEESADKADGAKTTEAEDKAAKAEEAKAIDDAKVDNANEAAKDDAGKAESAKDVEAVAPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYA9</accession>
    <name>A0A0D2VYA9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_006968</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYA9"/>
    <dbReference type="FunCoup" id="A0A0D2VYA9">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYA9"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYA9"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYA9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="380"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="933"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="998"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1225" mass="132265" checksum="FAFB8BC018BBDDEB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYR1</accession>
    <name>A0A0D2VYR1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343858.1">
        <property type="nucleotide sequence ID" value="XM_004343808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYR1"/>
    <dbReference type="FunCoup" id="A0A0D2VYR1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYR1"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYR1"/>
    <dbReference type="OMA" id="YTHPIEY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYR1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="293" mass="34625" checksum="44212E56D727FA61" modified="2015-04-29" version="1">MSVNASVFNAAAVSQDWTYLSSARYAEMGAFEACWTWMTDNFTEYQIATWGSLILHQVIYFGLCLPGFLFQFLPFMRRYKLQQEKPETWELQWKCFRMLMFNHFCIQTPLIMGTHSFMRYFDIPYLYKDIPAWYILAAQVFACLVIEDTWHYFMHRLLHHKAIYKYIHKVHHTFAAPFGMVAEYAHPAETLILGVGFFLGVLIFCNHLILNWAWVTLRLIETIEVHSGYDIWTPLHLLPFYGGAKFHDFHHMNFTGNYASTFTFWDKLFGTDESFNKYQKEVAAKKAKQVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZ37</accession>
    <name>A0A0D2VZ37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZ37"/>
    <dbReference type="STRING" id="595528.A0A0D2VZ37"/>
    <dbReference type="eggNOG" id="KOG0124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZ37"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZ37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="236"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="532"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="624" mass="66749" checksum="5BA77796A90BC3CC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZB5</accession>
    <name>A0A0D2VZB5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZB5"/>
    <dbReference type="FunCoup" id="A0A0D2VZB5">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZB5"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZB5"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZB5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="594" mass="63914" checksum="1D1C17C7AB4AE124" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W149</accession>
    <name>A0A0D2W149_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W149"/>
    <dbReference type="STRING" id="595528.A0A0D2W149"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W149"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W149"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="571" mass="63124" checksum="4832E11C0A3FAF35" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH78</accession>
    <name>A0A0D2WH78_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH78"/>
    <dbReference type="InParanoid" id="A0A0D2WH78"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="284" mass="33322" checksum="17E938165F52DC14" modified="2015-04-29" version="1">MHGALFKRLNLRTQRRCQLQFCHSIIQQVEQVGGGRVGRRRASPSSRRGGRCRTGLGREELERQGLLELLEFDVELRRAEVWRVVQNKRDERHVHRFQCSTEHFKHSVDSLASQSRGAKGNELIADGQCRVCACCRRARHDAGDVHDGTQRRSASQVQAERCLGRQHSTAVGQRLVAGQMGLLSFCFWPAFARRRVNSKSNRSSSRRRRRRRRRRRRRRGMGSRWRRGSRIRYCWGGKSGICRPTCCSIAWVGYHSWERRLADKRRDLSRRVRVQRHCRITRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIK0</accession>
    <name>A0A0D2WIK0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269981.1">
        <property type="nucleotide sequence ID" value="XM_011271679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIK0"/>
    <dbReference type="InParanoid" id="A0A0D2WIK0"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="959" mass="101864" checksum="C3B5CDBC361EC56D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIN4</accession>
    <name>A0A0D2WIN4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIN4"/>
    <dbReference type="InParanoid" id="A0A0D2WIN4"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIN4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF76">
        <property type="entry name" value="HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="332"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="522"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="575"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1332" mass="142142" checksum="84CC82D62F993A96" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJM5</accession>
    <name>A0A0D2WJM5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365887.1">
        <property type="nucleotide sequence ID" value="XM_004365830.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJM5"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJM5"/>
    <dbReference type="OMA" id="VITRIAC"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057248">
        <property type="entry name" value="Alsin-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25383">
        <property type="entry name" value="PH_alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="129"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="313"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="943"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="2090"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1551"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1579"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2245" mass="241704" checksum="C825FC99445C03B9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK04</accession>
    <name>A0A0D2WK04_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK04"/>
    <dbReference type="STRING" id="595528.A0A0D2WK04"/>
    <dbReference type="InParanoid" id="A0A0D2WK04"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255017" evidence="8">
        <location>
            <begin position="21"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="893" mass="96805" checksum="6EA3ABD4759BF443" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK19</accession>
    <name>A0A0D2WK19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK19"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK19"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="719"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1060" mass="111234" checksum="EE8F7F170FD66ED5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK21</accession>
    <name>A0A0D2WK21_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349813.1">
        <property type="nucleotide sequence ID" value="XM_004349763.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK21"/>
    <dbReference type="STRING" id="595528.A0A0D2WK21"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK21"/>
    <dbReference type="OMA" id="WKTSYRI"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="298"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="802" mass="88723" checksum="48DACB6FC27A368C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLL9</accession>
    <name>A0A0D2WLL9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349374.1">
        <property type="nucleotide sequence ID" value="XM_004349324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLL9"/>
    <dbReference type="InParanoid" id="A0A0D2WLL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34831" checksum="2DA7A7C897A4772F" modified="2015-04-29" version="1">MFPTAGDQNDDTQTIDLEELRIRLVDQNAPSAELNEVMELLQLAFTADSTAGQRASISDDALGLIVQLFFQLFDEENERLFRVVGRTIAFWLYNNETAKRRLREQTFTMSPAKSPLTFLAHLNDRFQTPQDSQNSKHLSTIALILQNWVYREPVAQLQVFDSAVFDAVVRHLHHVSLSRLSDIKKEMLFVQRACQVFVEINIGECLSQAVEDAKRFVNLLAEVFEICFAVPLAHEPCLEALDAIIQLHPTNMFELPESTVSHIIMLLGGVPDDQALLQGLLDRAHPHRIIVLPTRIVSAVANFDLCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLN6</accession>
    <name>A0A0D2WLN6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLN6"/>
    <dbReference type="InParanoid" id="A0A0D2WLN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="88" mass="10054" checksum="19DDA56A496880A8" modified="2015-04-29" version="1">MTVVSDMDILKVLLEVPTAKLANIRGRTPYCSAVHNQLPGELIKRLLKTRFSVDLNDRGRVVQAKTPMWLRDHLDRAALDDRQWLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM92</accession>
    <name>A0A0D2WM92_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349139.1">
        <property type="nucleotide sequence ID" value="XM_004349089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM92"/>
    <dbReference type="STRING" id="595528.A0A0D2WM92"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM92"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="35661" checksum="17111B134DB0697F" modified="2015-04-29" version="1">MNPAQTSYFNPADATALLDMKPSRVPLAEHRKQMAELERLKIVMANSAHLMGAVSSAAAAASAPASSHHQGFMEVFANAIPAAAPLSARSAVSEEDESLDTFSNEDGTPANLMDDLLIDFDVNAFSSMNVDLGATTTLPAAVPAAALPSAALPSAALPSAMPSSLPAAATVQTATANANATAAAVAAAFVAAASANAAAPGHSLPGPFGFNPLAAAPMGAWAPGQFNPSVAAAAAVLGLAPMIDQSNMMRKQRRRDSHNAVERRRRDNINDRIIELSALVPDNGGEKANKGETLRKAVDYIRYLHQCQARSFEQLKEATKQMQAMNAEIEALRKITGAAPSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMR9</accession>
    <name>A0A0D2WMR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349396.1">
        <property type="nucleotide sequence ID" value="XM_004349346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMR9"/>
    <dbReference type="STRING" id="595528.A0A0D2WMR9"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMR9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMR9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="696"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1039" mass="111444" checksum="45008D89CC2BC80B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNR0</accession>
    <name>A0A0D2WNR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Purple acid phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363939.1">
        <property type="nucleotide sequence ID" value="XM_004363882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNR0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNR0"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNR0"/>
    <dbReference type="OMA" id="VWDHFFN"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040974">
        <property type="entry name" value="Fn3_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778:SF7">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17808">
        <property type="entry name" value="fn3_PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113520" description="Purple acid phosphatase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase Fn3-like" evidence="10">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="298"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="8">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="604" mass="66908" checksum="D6304C32574578F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNR8</accession>
    <name>A0A0D2WNR8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363484.1">
        <property type="nucleotide sequence ID" value="XM_004363427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNR8"/>
    <dbReference type="InParanoid" id="A0A0D2WNR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052473">
        <property type="entry name" value="mtLSU_mL53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="104" mass="11244" checksum="07A65310C319C5C4" modified="2015-04-29" version="1">MAGTNSLKHALKFVKDVNVVFSPWNMNAKHARLVLQQVAASKGQDPALKTNVAVVNALQNQTAPTVSVVLSDNTKLEFNCNRQSAKEIVDTITNKALELDIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNT8</accession>
    <name>A0A0D2WNT8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363525.1">
        <property type="nucleotide sequence ID" value="XM_004363468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNT8"/>
    <dbReference type="FunCoup" id="A0A0D2WNT8">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNT8"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNT8"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="24814" checksum="A175DA37DC5A0481" modified="2015-04-29" version="1">MRLFGKPKPAAPVPRDAIQHLRETIETLEKREKFLEKKMEAELETAKRLVSKNKKGAMLALKRKKLYEAQIEKLTGARMTLETQVLTIEGSTVNLQAFNAMAQGAASMRAIHGQMNIDRVDAIMDDVREQMDLASEVAGVISEPLGNNDIDEDELNAQLEELEQEELDAKLLDVQNVPTTSLPNVPTTELPTPAAAAPSKQKASRVRDEDEDELEQLRQAMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNU9</accession>
    <name>A0A0D2WNU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNU9"/>
    <dbReference type="InParanoid" id="A0A0D2WNU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="493" mass="49795" checksum="735DB057733B6038" modified="2015-04-29" version="1">MVSSPKSKRKASQDAAVAAIAKARMEEAAIAGGADGVDFAVTQSTLKRGISGQTSRVTVQHRRSPSLVASSGLPVLDPARSIQIEISATTATLEGLLNRFALLYVPSLPLDGLALSISSTLNPADSVPIMSDFDLHQVLVGLDGADFHACVTSSQLPPTSPISPSGSCLTINTTTAAAAAAAAGRQSLTGIPTPPPSAPLTASFASSSALSLPKRTLSAESMSPRSLSDTAVDEQTGAAADAAQASAEAASSSSSSSSSSSSANNSTPVSNATAAADATVATASPAAAAAAAAAASRTGSTPGSPPMLRKHIARRDSYSAQAAMAARRSIHEDSTVFDSTGLPASPVRNLATAEAVSEPQRGRLVRSHSISNQTATRVNSQDGSESPTSPDPGSDKSSPTSSAGSSPNSTLSGTDSVSKRERRGLSSFFRRKSSSSRSNSLSSLSQPSLSDLGLEPLGSPTGRTSPSGTVTASILTFQQQQPQLQHTHCPPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPF7</accession>
    <name>A0A0D2WPF7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347889.1">
        <property type="nucleotide sequence ID" value="XM_004347839.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPF7"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPF7"/>
    <dbReference type="OrthoDB" id="6503529at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPF7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF71">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="2366"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="9">
        <location>
            <begin position="3937"/>
            <end position="3969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2498"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3780"/>
            <end position="3799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3782"/>
            <end position="3792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3969" mass="427386" checksum="33B219557AC88756" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPU7</accession>
    <name>A0A0D2WPU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome c peroxidase, mitochondrial</fullName>
            <ecNumber evidence="12">1.11.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.5" evidence="12"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270396.1">
        <property type="nucleotide sequence ID" value="XM_011272094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPU7"/>
    <dbReference type="STRING" id="595528.A0A0D2WPU7"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPU7"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPU7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="152"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="357" mass="38859" checksum="B2EFF44FB049CE12" modified="2015-04-29" version="1">MSARLIRVVATAALPLRTGAVRTASNAAAVVAVQQQRSYSHGQGQGRSSNGKSSKFATGAATAFAAATTTGLMLVVSASEKTSKKGDYAAVRKDIADILDDSNYDDGSYGPAFVRLAWHASGSYSTFDKTGGSNGATMRFSPEAKYGANNGLERARARLEQVKQKHPWITYADLWTLAAVVAIEEMGGPKVPWHGGRVDDADNKRTAPDGRLPDAARGADHVRAIFYRMGFNDQEIVALIGAHVIGRAHDGKSANGSGYSGPWTFNPTTFNNGFYTTLLNTKWTEKKWNGPKQYTDPTGELMMLPADLAFLQDADLRKWVEVYAKDEKKFFEDFSAAFSKLLHLGVPAKTSCWWWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPZ9</accession>
    <name>A0A0D2WPZ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348182.2">
        <property type="nucleotide sequence ID" value="XM_004348132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPZ9"/>
    <dbReference type="STRING" id="595528.A0A0D2WPZ9"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPZ9"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="700" mass="77267" checksum="DAAD8A653287C2D9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQG7</accession>
    <name>A0A0D2WQG7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347389.1">
        <property type="nucleotide sequence ID" value="XM_004347339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQG7"/>
    <dbReference type="InParanoid" id="A0A0D2WQG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="669" mass="73508" checksum="187AD655A487C6DF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRK2</accession>
    <name>A0A0D2WRK2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346857.1">
        <property type="nucleotide sequence ID" value="XM_004346807.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRK2"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRK2"/>
    <dbReference type="OMA" id="EAQPYVC"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRK2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF18">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="717" mass="79040" checksum="55803FD3960D8DA2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRL6</accession>
    <name>A0A0D2WRL6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346873.1">
        <property type="nucleotide sequence ID" value="XM_004346823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRL6"/>
    <dbReference type="FunCoup" id="A0A0D2WRL6">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRL6"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRL6"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRL6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="104" mass="11871" checksum="D4DF09AF7F0CF087" modified="2015-04-29" version="1">MTVESLSVGLKKGFKVTSRARPVRPVSRKGHLSKRVKFIRDIVREVSGYAPYERRIIELLKVSKDKRALKLAKRRLGTHSRGKAKREELQDALAQMRKAASAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS22</accession>
    <name>A0A0D2WS22_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347579.1">
        <property type="nucleotide sequence ID" value="XM_004347529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS22"/>
    <dbReference type="STRING" id="595528.A0A0D2WS22"/>
    <dbReference type="eggNOG" id="ENOG502S2NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS22"/>
    <dbReference type="OMA" id="IIHIFHS"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01014">
        <property type="entry name" value="nicotinamidase_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="204" mass="22166" checksum="09C21A444B984E7E" modified="2015-04-29" version="1">MSQPSTSPERVLGRLPGLVLVDVQLGLTDPANEAHWGGNRNNRNAEQVIGRLLQLWRARNLPVFHVKHDSIEAQSPLRPDQPGNAFHPVAVPLPNEPVFPKSVNSGFIGTDLQARLEQRGVTSVVIVGITTDHCVSTTTRMAGNLGFVCFLVEDAVATFDKTGYNGVKYPAQLIHDTALASLHDEFATVLQSQTLEQKLAAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSI1</accession>
    <name>A0A0D2WSI1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSI1"/>
    <dbReference type="InParanoid" id="A0A0D2WSI1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="10">
        <location>
            <begin position="666"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1340"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1474" mass="156786" checksum="2613B310F5CC1775" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSZ4</accession>
    <name>A0A0D2WSZ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345494.1">
        <property type="nucleotide sequence ID" value="XM_004345444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSZ4"/>
    <dbReference type="FunCoup" id="A0A0D2WSZ4">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSZ4"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSZ4"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="274"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="370" mass="40850" checksum="AAA79FD34E328C92" modified="2015-04-29" version="1">MANALEELADFLKDSRSLVRAHAVDTVAGLTASADGLEYIRAYPRLADELLARLSDADPGIARDAFKAVVNMTGDRTLAQRTIDVPGLFAHLVATTTEPTSLFADLAAMVLSNLTRNELGCGKLLGTNTPEEGQALYKLVDVFCKGAFNHNPNASLNFLAPILENVSQSNLGRRLLVDQERAVLPRLLTHLENPDRVRRGGVAGIARNCCFETAAHEYLLGEKVDILSFLLLPLCGPEEFDDEDMDGMPDCCQYLDSSKQREPEVSIRRHLVEALYQLCATKHGRTVLRAKKVYPIIREMHKHETDSDLDKACDHLVQVLVGEESGHEDLKQVPLPESYTSKLAEQVRPTTSIEDDNDDDAIMVDDPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT98</accession>
    <name>A0A0D2WT98_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_005419</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346092.2">
        <property type="nucleotide sequence ID" value="XM_004346042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT98"/>
    <dbReference type="FunCoup" id="A0A0D2WT98">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WT98"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT98"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="374"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE94848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="693" mass="74850" checksum="0ED2EAF28FA68A61" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTC4</accession>
    <name>A0A0D2WTC4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345677.2">
        <property type="nucleotide sequence ID" value="XM_004345627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTC4"/>
    <dbReference type="InParanoid" id="A0A0D2WTC4"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTC4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="195"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="424" mass="46204" checksum="9CD85C8105AED9CE" modified="2015-04-29" version="1">MLLSTRCGIRQMALPSTQALMASAMRLAHKSHATPNVKSKSELDRLHDEQVGSKGEDTAMYPEFQPPPRSSDAANLKRDAGTRGINAAAERFLTGRMASDLLADKAERLRTLGVVSMRETDTALDAVQRMAELNLGSVIVVPSKIGGAEGQPTSGALGPKDTSVSAMGVFTEAHYVKSVLLKGLNPARVTLGEVAARGITCVSANVPIEQVMQRFIDTRVRNLPVIATADTTDSKVSPHSLPRVVGILSMGDLHRSLVMRLNDFPFMESVLVRDVLALPESGLKFGVVDHTLDELRIDHNKSASHALELMIKHRTHVCFVHQASSFLGLLSMRSCIRAAAAGRDLKSVKVESLMETDITVVTPEFPLVQAMKALVQIERFVLPVSTYIGDTFDADMRLAGVVSVLDVLNMFHFKYHALRMAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTH6</accession>
    <name>A0A0D2WTH6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTH6"/>
    <dbReference type="InParanoid" id="A0A0D2WTH6"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTH6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="9">
        <location>
            <begin position="312"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1592"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1666" mass="181997" checksum="9FFC216E04C71EA1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTJ0</accession>
    <name>A0A0D2WTJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346187.1">
        <property type="nucleotide sequence ID" value="XM_004346137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTJ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WTJ0"/>
    <dbReference type="eggNOG" id="KOG3514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTJ0"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255231" description="Laminin G domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="220"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="50519" checksum="989FB0ED9297901A" modified="2015-04-29" version="1">MSASAKTSHLACILVAVVAMYAAVVSADCPSDEPAVFFGEKGYLTFPNAYGLAINTHSTLFKQMSLDLKLRKGPSASREFRVFSVRHNYWVDFLDVWVNVLCDDSAQVVVNFNAGQGPVSFSADFNELLDHEWHTLEVTTSPGRVFIYIDTEMVQEHYYLGGPTLNVNVNGNVKVGGTRSGDMFHGCIRNIVLEHLHFDGRDAYPTGEVKYDCSISQDASLPTGNERVEFFPLSSRTLTDIRFWFRGTTTDGVLYLQKGASDSVTVELYNNALNVILRNNAGNDLHNEQFAGPFDDNVWREFSLSRFGSEFTAKISTPGFYPDVLVHDNLLNSGLITLTGNSLFGGLSPAFPVGGGNATQGYQGCLRDLSGGGVPRLIQDALDKPGVVLDDCDCLQCTNDAQRGCPIAFNGTGAVLERNDEVAKVTLRSHMTEVDRVHVGRSAAVHRTCYGHRQQASANSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTX2</accession>
    <name>A0A0D2WTX2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346344.1">
        <property type="nucleotide sequence ID" value="XM_004346294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTX2"/>
    <dbReference type="STRING" id="595528.A0A0D2WTX2"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTX2"/>
    <dbReference type="OMA" id="CEEINEQ"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTX2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="825" mass="89082" checksum="3C65DBB1A8112F5C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU59</accession>
    <name>A0A0D2WU59_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_005847</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU59"/>
    <dbReference type="STRING" id="595528.A0A0D2WU59"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU59"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU59"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 14" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="18">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="18">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="705"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="184"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="233"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE95393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1053" mass="111373" checksum="27FB9EC1668F4628" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUR8</accession>
    <name>A0A0D2WUR8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUR8"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUR8"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="106" mass="12277" checksum="B66A92328F82F790" modified="2015-04-29" version="1">MSADAALQINGELLYLRYRVNLIGDFLTVPVFYWNREELDTLYRSLVRVMDIPHRITVINRRLDHALEIAALCRNLTTEAKGTRLEVIIIVLIAVEVVFEMIHLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV96</accession>
    <name>A0A0D2WV96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343729.2">
        <property type="nucleotide sequence ID" value="XM_004343679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV96"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV96"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41576" checksum="C4301653AA008140" modified="2015-04-29" version="1">MLSYESMTERQRQLYDRVNNTRNLNLSRCQSQIGDAEAQAIAEALKVNSTVTTVVLWYNQIGDAGAQAFAEALKVNTTMERLYLGGNLIGDAGAQAIAEALKVNTTLPMLYLSDNQIQDAGAQAIAEALKVNTTVTVLGLDRNLIADAGAHAMAEALKVKKTWTELDLSGNCIGKVGVQALEEICKTNCDPAVDFRCQINPLAFGYLPRCASAEELQTVFHLLSSGPDLQDQSASLPVLPAEIAERIMDEAHYWQGVKYTKRDWLRDCTNEHFKVTLPQGIDGPSIRVKAIRVLLDRWEDSKAAASCVFDLIVQDEQGVVRSELSVTPNCVDSTVELGTLLPASHPIIRQMRGGWQVRAQQDKFTDSVRSSWLYVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVG3</accession>
    <name>A0A0D2WVG3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343830.1">
        <property type="nucleotide sequence ID" value="XM_004343780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVG3"/>
    <dbReference type="STRING" id="595528.A0A0D2WVG3"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVG3"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="697"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="926"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1125" mass="115719" checksum="9358D75404C52F84" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW81</accession>
    <name>A0A0D2WW81_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease GajA/Old nuclease/RecF-like AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW81"/>
    <dbReference type="InParanoid" id="A0A0D2WW81"/>
    <dbReference type="OrthoDB" id="2105540at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_GajA/Old/RecF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease GajA/Old nuclease/RecF-like AAA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="678" mass="74505" checksum="11CB761B509BDBB4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWR3</accession>
    <name>A0A0D2WWR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWR3"/>
    <dbReference type="InParanoid" id="A0A0D2WWR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255321" description="RRM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="79198" checksum="18B9FFADCC13CA56" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWY3</accession>
    <name>A0A0D2WWY3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007613</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343487.1">
        <property type="nucleotide sequence ID" value="XM_004343437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWY3"/>
    <dbReference type="FunCoup" id="A0A0D2WWY3">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWY3"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWY3"/>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWY3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="23"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="34262" checksum="A8F65639B95D1220" modified="2015-04-29" version="1">MFAVSARAFSTSSINNAKVAVLGAAGGIGQPLSLLLKESTLVSDLALYDIANTPGVAADLSHINTKSTVKGYTGADQLGAALKGASVVVIPAGVPRKPGMTRDDLFNTNASIVMNLAKAAAQHCPKALIAIIANPVNSTVPIVAEVFKKAGVYDPKRIFGVTTLDIVRANTFVAQARDLDPQAVNVPVIGGHAGITILPLISQSSPKVTFNDAAELEKLTVRIQNAGTEVVDAKAGAGSATLSMAYAGARFTFSLLKGLKGQKAVECAFVESSVTKVPFFATPIALGPEGVKENLGLGLLSDFEKKKLEALFPELEASIKKGVEFVAKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXE2</accession>
    <name>A0A0D2WXE2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343011.1">
        <property type="nucleotide sequence ID" value="XM_004342961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXE2"/>
    <dbReference type="STRING" id="595528.A0A0D2WXE2"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXE2"/>
    <dbReference type="OMA" id="KMKHQEL"/>
    <dbReference type="OrthoDB" id="5966500at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF86">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="400"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="669" mass="73123" checksum="C010D08AB9BD8CBD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXV8</accession>
    <name>A0A0D2WXV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270836.1">
        <property type="nucleotide sequence ID" value="XM_011272534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXV8"/>
    <dbReference type="InParanoid" id="A0A0D2WXV8"/>
    <dbReference type="OrthoDB" id="45963at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF1">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="122" mass="13499" checksum="43DF623AA7EA8C4C" modified="2015-04-29" version="1">MNMSQLPLNAPPSSTTIDSSSSSSVSTAPPPPATVMDSLWAVGYRVLGVIDYLGETFTGWLGITSPRYQYVIDEIERRKRLELDEDEQEDQVATARIANEEAAMQPQQQQPQALHKQAQPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY10</accession>
    <name>A0A0D2WY10_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein kinase transforming protein SEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342493.1">
        <property type="nucleotide sequence ID" value="XM_004342444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY10"/>
    <dbReference type="STRING" id="595528.A0A0D2WY10"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY10"/>
    <dbReference type="OMA" id="CEMYEAS"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="18213" checksum="8BE4D27427B7AAEE" modified="2015-04-29" version="1">MEYLGTLHFVHRDLAARNCLVGKGMVVKIADFGLSREMASENDYYRMQTRGKLPVKWMAPETMTFRKFSSMSDVWSFGVTAWECSSHGARPYGEMDGRDTLAHVEAGGRLPMPQTCMPELYNVMMSCWDMSPENRPTFAQLVRTLTALQDGTTIREIGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY70</accession>
    <name>A0A0D2WY70_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270846.1">
        <property type="nucleotide sequence ID" value="XM_011272544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY70"/>
    <dbReference type="FunCoup" id="A0A0D2WY70">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY70"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY70"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY70"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="10">
        <location>
            <begin position="120"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="300" mass="31900" checksum="A53BFB5A44E1B2B3" modified="2015-04-29" version="1">MSNSTSTPTAPLAPSSSASTSTSQADEIAELRAMLAAANARLSGLQQQGAITTTAAATTTGTAAAAAAAAAAAAAAGGGPAGAIPLSRRPSTGLSWPSVGALERRAESREDNEARIERMAAAVRELLTCIGEDPTREGLLETPYRMAKALLFFTKGYQELPTEIMNNAIFVEDHDEMVIVKNIDVFSMCEHHMVPFIGKCAIGYIPNKKVLGLSKVARLAEIYSRRLQLQERLTKQIAVAIQESIDPQGVAVVVECSHMCMVMRGVQKSGSSTVSSSMLGVFRSDPKTREEFLTLIRDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY87</accession>
    <name>A0A0D2WY87_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346403">
        <property type="protein sequence ID" value="KJE98370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY87"/>
    <dbReference type="InParanoid" id="A0A0D2WY87"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="284" mass="30773" checksum="4753A5BD9161A6DE" modified="2015-04-29" version="1" fragment="single">MSFANSESTATTLAAVRAVLVNPAIAVAGSEDILRDDDSSAATTAATAGGPQQQQQQQQQDGAFAAESGNSRAMLRAAQGRLVPDRDQEEHEDENDLYNHEDPAVAAAAPAIDRQRRAVENALALLNTYCEALLHAQPTSVRQAQFDDLLRNHFPLSLLLNYLNPGNPESVWELTVQVLKKVFVGWAPDAETAAWVKPFVIQGFHHPYVGVRTLSILQLSRIARVHSNFLDDELITLTMGLLADPLLPVAQQATAMLLDALGHEQSGGPLLSPRFQQTLLALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYB1</accession>
    <name>A0A0D2WYB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346417">
        <property type="protein sequence ID" value="KJE98410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYB1"/>
    <dbReference type="InParanoid" id="A0A0D2WYB1"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270269" evidence="2">
        <location>
            <begin position="17"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="816" mass="90841" checksum="7005C5BAE7A13B2C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X042</accession>
    <name>A0A0D2X042_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364934.2">
        <property type="nucleotide sequence ID" value="XM_004364877.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X042"/>
    <dbReference type="FunCoup" id="A0A0D2X042">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X042"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X042"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X042"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="235"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="601"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="845"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="961"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114290" checksum="5801209F52AAFB4D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X060</accession>
    <name>A0A0D2X060_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Superoxide dismutase</fullName>
            <ecNumber evidence="3 9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365015.1">
        <property type="nucleotide sequence ID" value="XM_004364958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X060"/>
    <dbReference type="FunCoup" id="A0A0D2X060">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X060"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X060"/>
    <dbReference type="OMA" id="GSYEGWK"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X060"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="229" mass="25010" checksum="D65C90D2A9DACAC6" modified="2015-04-29" version="1">MLQSAALVRSVASRASATAAVAAAVPMRAKHTLPDMPYDYSALEPVISAEIMKIHHSKHHQAYVNNLNIAEEKYAEATAKNDLSAQIALQSAIKFNGGGHINHSIFWTNLAPASQSGSPSAELNKAINAEFGSFDAFVEKFNTQTAAVQGSGWGWLGYDKTKGRVVITACANQDPLQALTGHTPLLGIDVWEHAYYLQYKNARPDYLKAIWKVVNWNNVNERFAAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X092</accession>
    <name>A0A0D2X092_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365134.1">
        <property type="nucleotide sequence ID" value="XM_004365077.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X092"/>
    <dbReference type="FunCoup" id="A0A0D2X092">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X092"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X092"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X092"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="56" mass="6702" checksum="48DE6E62D86279A9" modified="2015-04-29" version="1">MSHESVFYSHPRKFGPGSRQCTVCSNRHGMIRKYHLDMCRQCFRQYAADIGFIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0J6</accession>
    <name>A0A0D2X0J6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0J6"/>
    <dbReference type="STRING" id="595528.A0A0D2X0J6"/>
    <dbReference type="InParanoid" id="A0A0D2X0J6"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0J6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="117729" checksum="C0537ACD55F57FFF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1K6</accession>
    <name>A0A0D2X1K6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1K6"/>
    <dbReference type="FunCoup" id="A0A0D2X1K6">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1K6"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1K6"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1K6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="239" mass="26465" checksum="35AC643118B91F6B" modified="2015-04-29" version="1">MNPASDDHDNEAELSLDGNAMFEEPENFRPKTPPPTEHVVARTVAGAVPAELRVRLVGHHSLWAHCMWNAGVHLAHYFDEHCALVRGKTVLELGAAAALPSMVAALNGALRGYLWGAQVAPLLTTLPADHKTFDVIVLADLIFNHNSHADMLRTCQQSLTRSKDAKVYVVYSHHRPWLAERDMAFFKLAAEEPFNFVVTPLFEVKMPPMFAEDPGDVDVRSTVHGHLLTWPEAALEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1N0</accession>
    <name>A0A0D2X1N0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349032.2">
        <property type="nucleotide sequence ID" value="XM_004348982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1N0"/>
    <dbReference type="STRING" id="595528.A0A0D2X1N0"/>
    <dbReference type="eggNOG" id="KOG0041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1N0"/>
    <dbReference type="OrthoDB" id="6572480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1N0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="20277" checksum="BAE256DAECB798A0" modified="2015-04-29" version="1">MQRRQDIDSGAEAGGKVTQVFNEYTEFPEFSRSELKKFKDMFKKYDTDKSGFLDLQELKYFMEQLGEPQTHVALKAMIALVDEDFDGTISYREFLLIFRKAARGELEAGSGLAKLAESVNVSEEGVGGAKNFFEAKSKQLADSNKFENEIKKEQEAKKAELEAAKQRRADFKSKAATFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1T2</accession>
    <name>A0A0D2X1T2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1T2"/>
    <dbReference type="InParanoid" id="A0A0D2X1T2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="201" mass="20808" checksum="136E8F1460BE34DF" modified="2015-04-29" version="1">MARPSQTKTQSANKHNRNKKQSSSSSSSSTSSSTTVKHAGVSKSAWTGAGRRLGGSSSSSSTVAKTSALPSPFAGVAAAGAGASASIRAATAAVAASRTRRQTNMANEELASRLDDTLELLQSSLTNGAATRTRVLAQIEHDQQQRQAAAMDQGMYMSDDVPSHEPVAPVNSAPAVPRTQQEIQATLRELGSTATTAQKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1V2</accession>
    <name>A0A0D2X1V2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26S protease regulatory subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349336.1">
        <property type="nucleotide sequence ID" value="XM_004349286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1V2"/>
    <dbReference type="FunCoup" id="A0A0D2X1V2">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1V2"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1V2"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1V2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="215"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="48611" checksum="C69781202C920AC7" modified="2015-04-29" version="1">MPKDYLGEDQRKVRADEDKDDKPIKALDEGDIALLKTYGVGPYTRSIKKVEDDIAAAVKHVNEIAGVKESDTGLAHPGLWDLAADKQMMQEEQSLQVARCTKIINVANPGPKEAASQYVINIKQLAKFVVGLADNVAPSDIEEGMRVGVDRGKYQIHLPLPPRIDPTVTMMQVEEKPDVTYADVGGCKEQIEKLREVVETPLLHPERFVNLGIDPPKGVLLFGPPGTGKTLSARAVANRTDACFIRVIGSELVQKYVGEGARLVRDLFDMARSKKACVIFFDEIDAVGGARFDDGAGGDNEVQRTMLELINQLDGFDARGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRANIFRIHAKSMSVERDIRYELLARLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLDAVNKVIKAYAKFSATPRYMTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2B9</accession>
    <name>A0A0D2X2B9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nibrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364129.1">
        <property type="nucleotide sequence ID" value="XM_004364072.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2B9"/>
    <dbReference type="STRING" id="595528.A0A0D2X2B9"/>
    <dbReference type="InParanoid" id="A0A0D2X2B9"/>
    <dbReference type="OMA" id="WQDDITH"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2B9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="59279" checksum="D8F4D92C75E598D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X329</accession>
    <name>A0A0D2X329_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X329"/>
    <dbReference type="STRING" id="595528.A0A0D2X329"/>
    <dbReference type="eggNOG" id="KOG1423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X329"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X329"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="409"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="488" mass="53395" checksum="848A3843EA288999" modified="2015-04-29" version="1">MQHEHCRIYYDDAATDDDDDDVHPIAVVAVVAVIVAVRRLPSDASFLHCRPSRDRRLAVNQAISMHETGQQERQDKAAPRGLVLARQASREHAAPLPRPIAAQQIASVQPDQLDTKREGSAPSIPAPVNAQPLVNPPAAQQPSANAPAHLADTPASPASPASPASPVGLVSGVISRRTSPHLVLPDVDPGLLVKFEQPKDSELVRVAVIGAPNAGKSSIVNSIVGRTVSIVSSRSQSTRERILGIATRANKQMVLFDTPGLLRFNFSRRIPIGRELSPESTRALLEADVSMVVYDVSKPLTPADHDLFAARNYPREAILVLNKVDLAPKADILARAEEIVSRPGAKQFEKVFLTSASAHGGVSDVTDFLMTKTQAGPWEVPADYNTDQSRHKIVCEVIRKHIFNMFVAELPYRVTQETTRWHDSDTTLEVSQKLIVPKASMMKIFIGTNGEKIKKLMALSEEELSRILGVQVYLHLEVKSPKDSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X345</accession>
    <name>A0A0D2X345_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Solute carrier family 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X345"/>
    <dbReference type="STRING" id="595528.A0A0D2X345"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X345"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X345"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="391"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="517" mass="57739" checksum="9C4D4FD07F8D8278" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3N3</accession>
    <name>A0A0D2X3N3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allograft inflammatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346914.1">
        <property type="nucleotide sequence ID" value="XM_004346864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3N3"/>
    <dbReference type="STRING" id="595528.A0A0D2X3N3"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3N3"/>
    <dbReference type="OMA" id="MDFGMSV"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3N3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049025">
        <property type="entry name" value="AIF-1_EF_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042433">
        <property type="entry name" value="AIF1/AIF1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356">
        <property type="entry name" value="ALLOGRAFT INFLAMMATORY FACTOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356:SF0">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21008">
        <property type="entry name" value="AIF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="141" mass="16050" checksum="5305737F216205DA" modified="2015-04-29" version="1">MAHQGGKAFGQLKAKQATDLDGINAEFLSSGTYEDLTEERLVEYRTKFMEYDLDHSGDIDLMELKQMMEKLGQAKTHLELKKMIAEVDLEGQGTISYRSFLTMMLGKKSSILQKILMFEEMNKEKPKPVGIARKKSLDELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X430</accession>
    <name>A0A0D2X430_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X430"/>
    <dbReference type="STRING" id="595528.A0A0D2X430"/>
    <dbReference type="InParanoid" id="A0A0D2X430"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="795" mass="85437" checksum="F3285960DC07BC2D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4C3</accession>
    <name>A0A0D2X4C3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344970.1">
        <property type="nucleotide sequence ID" value="XM_004344920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4C3"/>
    <dbReference type="InParanoid" id="A0A0D2X4C3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="196" mass="19955" checksum="8732D8AF6AB7F06F" modified="2015-04-29" version="1">MALHDQQSPLSLSLSLSLSHSTLPNRRSSLPSASASASAAVALAAPTTLGPSVPPSLHPPAPHAAASVTPAATATTSAPTSAPLASASLPLNLPLPPPTQPLAPSATPRVLSRILRSLSIDSEPTNSNKNAPLPISNNETAIPEQDEVPANITKDTAPRAGSPLTPDDLLLDCIEPSFDYSTSSTWCGLDSDSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4W5</accession>
    <name>A0A0D2X4W5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343765.2">
        <property type="nucleotide sequence ID" value="XM_004343715.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4W5"/>
    <dbReference type="eggNOG" id="KOG1829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4W5"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF12">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RUN DOMAIN CONTAINING M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="10">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="722"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="832"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1512" mass="160282" checksum="89C77DA37065FBAC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4W7</accession>
    <name>A0A0D2X4W7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4W7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4W7"/>
    <dbReference type="InParanoid" id="A0A0D2X4W7"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4W7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="46722" checksum="139D343720772EF3" modified="2015-04-29" version="1">MVTSIKPSRTLQTITHDDAVDDEHGEQAKGPLVQDDDGDDDQANMHLLCCICVEPLVDNRQCPRCCNMCCKKCLESWVAARPTHLVAVPCPMCRQPAHLNDFKLNAEKQQAADAIMLRCSDGCGAVLRACDRGAHATRFCLEATIPCPFIHCKATMKRKSLDVHVFSCPFRTQYSEKELEAAVDLAEGRSVQDESRVKAALRASSLRQETIVHYVKENETLAGLAIKYGTSKEEIKRLNRLVADNIHTHVILLMPKSSVVPPPPAEPNKEVLEALRRRRMLKQFIRVAECELHEHAASTQEYFRCFGCKVRELDDQRTHCSSCGRFFCSACSPTICGQSVSKQSLGATTPTSHLEFVRVCEPCFTQLDNQPVPTMLVQPASRSRGGRGNPFAVPVAAEEEDVYHFDMVQTEREPLLVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5G0</accession>
    <name>A0A0D2X5G0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5G0"/>
    <dbReference type="FunCoup" id="A0A0D2X5G0">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5G0"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5G0"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5G0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="133"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="784"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="980" mass="106799" checksum="72C61AA1F11C4DDE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P0</accession>
    <name>A0A0D2X5P0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate lyase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5P0"/>
    <dbReference type="STRING" id="595528.A0A0D2X5P0"/>
    <dbReference type="InParanoid" id="A0A0D2X5P0"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5P0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17886" checksum="7FA2482AF67B0292" modified="2015-04-29" version="1">MVASNYATLSRQPLHRHDRRPIAPASLSPVCPSLSLHPSLHPNSMSLHPPALDGRLRSPWSSLSRRFMSSHPSAHPLPHSAASVHQQHTSQATPLFAAVPANTTTDERSETDSMGAIGVKHTAYWGAQTQRSLHHFSIGTDHFPRAMIRALGILKKVQLHPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZW9</accession>
    <name>A0A0D2TZW9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364997.2">
        <property type="nucleotide sequence ID" value="XM_004364940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZW9"/>
    <dbReference type="FunCoup" id="A0A0D2TZW9">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2TZW9"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZW9"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="399" mass="43973" checksum="3B2DA0D59627DEBF" modified="2015-04-29" version="1">MGSENASPTLSLLISRCSADSHPETQATCIESSKQSHTALKTNENKHQSSAMTESDMLKEDLYKLLNVEPTATEKEIAKAYRVGALKCHPDKNPDNPAAHELFQRLSRAYEILGDEKARQAYDGLLTARNVNKARVSAMNDRQRELRADLERRESEASARRAAAAAAGAAENGGAANKRPRMDEDHLRAQLAHEIERLRKDGMRRLQEEQEKMRRTIEEERKQATHAAYAFTSEAQPMQQHDAQSASASVVIRWNPSADPPLTEDTLREMLGACGGLDTLLTSKNPGSAVASFASLEGAARALAAATNLSNAPIGADLKLKIILKEDSGAPADQAELVAALVQRHRAFRFPQMAGRQSDSSLRRSTQTPIPADATEYERVTLLRMREAQERRRLQHAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2N5</accession>
    <name>A0A0D2U2N5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2N5"/>
    <dbReference type="InParanoid" id="A0A0D2U2N5"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2N5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34010" checksum="BD228FD7DCDC656B" modified="2015-04-29" version="1">MLTKRSNRLCDELIGVAEARAIAEALKANKTLREFRLSGNQIDDAGAQAIAEALKVNKTLTILFLDVNQIGDAGAQAIAEARKLNSHLNWINLRFNCIGNVGVQALVHACTGDSILTRLDIDYQINPLAFSLLPRFASAEDVQTVFHLLISGPELEDQSAAALPALPTEIAERLMNEAHYWQGVQHIKRLRSVFGNEVNDVLKVTVPENAIRVKAIQVLRERTTPTDSTGDREVKLIVRNDRCFPYSFTAKPTALSSTFDLLTIEPASHPIVGQIGDGSEVQVRFSPSAKDALFEALRVIYDDQGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5C4</accession>
    <name>A0A0D2U5C4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FK506-binding protein</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364538.1">
        <property type="nucleotide sequence ID" value="XM_004364481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5C4"/>
    <dbReference type="STRING" id="595528.A0A0D2U5C4"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5C4"/>
    <dbReference type="OMA" id="KVEMRYI"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5C4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="303"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="390" mass="41542" checksum="3AAC1CE3F38AB293" modified="2015-04-29" version="1">MSAFWGVEIEPGKMYSQLVSASFYIKLASLGAEVEDDARATVYLTAERKTFPISTLIGGRIMQQNLDLYIEEGTKITFRVSGQVPVHLVGHLAPIGEYMDYDDDDDEYDDDEEDADLEDMDDEEDSEDDDVQTKKALRRLIADEADDDEDDDEDDEEDDEEDLEDEDDEDDEEEDEEEDAPVNGKKRAAITSLPDSKRARVEEKKPEAAKSAQTPTKPVVAAAAAAAAAASPAQKGKQTPAAAAASPAQKAAAAAASPAQKAAASPAQKPAAATASPLQKKTLQGGLVMEDKVVGTGALAAPGKKIACYYYGKLKSGKMFDSCTSGKPFGFKLGAGEVIKGWDIGIAGMRVGGKRTLTIPAPLAYGARGSPPTIPPNSTLTFDVELKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5R3</accession>
    <name>A0A0D2U5R3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364654.1">
        <property type="nucleotide sequence ID" value="XM_004364597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5R3"/>
    <dbReference type="InParanoid" id="A0A0D2U5R3"/>
    <dbReference type="OrthoDB" id="2105540at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5R3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051396">
        <property type="entry name" value="Bact_Antivir_Def_Nuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581">
        <property type="entry name" value="ATP/GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581:SF4">
        <property type="entry name" value="ATP_GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="2">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="625" mass="69884" checksum="31F10439C7521A16" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5Z4</accession>
    <name>A0A0D2U5Z4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_001844</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364712.2">
        <property type="nucleotide sequence ID" value="XM_004364655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5Z4"/>
    <dbReference type="STRING" id="595528.A0A0D2U5Z4"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5Z4"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5Z4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="18">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE90541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="391" mass="43219" checksum="7EFA42609AD97995" modified="2015-04-29" version="1">MPPPPSSPAVGSGTSDAFSGLAFRLKKRLQKQYREFLLQHGQPTGLAYVLVAAIMVLILFVVITSFTSPRGMDDFRDMHKPTERRISIIVPTYKEAENLPPLAERVFAACAKSNLDAELIVVDDNSQDGSVEAVETLAKTYNMRIVVREHERGLSSAVLRGFQEAEHPVLVVMDADLSHPPESLAELVEPIIQGVSDFTIGSRYADGGSIKDWPLLRRLISAGATMLARPLVSVSDPMSGFIALRRRMWLGAQNVNPMGFKIGLELMIKSHAQRIQEIPISFTDRVRGQSKLKLKTQVQYVLHLMSLYWYVYPMLFTGTVLATLGICVLVARAIVRRSRRGFFGGSSVLPQYRTAHPAGAHSQFGNGSNDRYHVDAHSFGLPSKSGFGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7B8</accession>
    <name>A0A0D2U7B8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348979.2">
        <property type="nucleotide sequence ID" value="XM_004348929.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7B8"/>
    <dbReference type="STRING" id="595528.A0A0D2U7B8"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7B8"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7B8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16074">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="629" mass="69740" checksum="01E532619938D649" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8R1</accession>
    <name>A0A0D2U8R1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002592</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8R1"/>
    <dbReference type="STRING" id="595528.A0A0D2U8R1"/>
    <dbReference type="InParanoid" id="A0A0D2U8R1"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8R1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="40"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="314"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="631"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1129"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1205" mass="131453" checksum="C6367E19AD84DCE7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCG3</accession>
    <name>A0A0D2UCG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363354.1">
        <property type="nucleotide sequence ID" value="XM_004363297.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCG3"/>
    <dbReference type="FunCoup" id="A0A0D2UCG3">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UCG3"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCG3"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="35910" checksum="3D12D0C5F1FF5CF0" modified="2015-04-29" version="1">MAHSEFEPSIRNLLDQNSLRWIFVGGKGGVGKTTCSSSIAIQLAKVRQSVLLVSTDPAHNLSDAFGQKFSKEPSLANGFSNLYVCELDAKDITMVNKMLGGSETSEQIHELLGSIPGIDEALSFAEMMNHLDNTEYSVVVFDTAPTGHTLRLLSLPVAIDKGLTAAIGAMNRFAPMISSVTSMLGRSELLGINNLVPRLEQLKLLTQRVQDQFKDPARTTFVCVCIAEFLSLYETERLIQELTGFGIDVHNIIVNQLVEQSVADCTLCDARVKLQGKYLDQIADLYEDFHVIKLPLLTAEVRGSKSLTTFSERLVGPAVASKATSTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCK6</accession>
    <name>A0A0D2UCK6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCK6"/>
    <dbReference type="STRING" id="595528.A0A0D2UCK6"/>
    <dbReference type="eggNOG" id="ENOG502S1NH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCK6"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCK6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="156"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="288" mass="31310" checksum="D982F2D1E9416BC1" modified="2015-04-29" version="1">MLKATRTSSSSKQPARAVSMSCSSASTMLSSNTHCSRTSEEVDLSHTVKFVYVHWNGNDVPFAKKGRFGVVHGAVQERFHPYHIDFDISAHNEISEQLIQEKLADASGTGKKVLDPLEAATRQARTFTASPSSQEALLNSKTGAKAPPMVGVNKDAVAVQADDSAAEAIADVRNDATETTWTILSYQDNDVKKPIIAVASGSGDRDQLRQHITTEMVAYILWRTTDVYEGITNVKFVSITWVGDQVKPMAKAKVSTHKGAITPIIGPVHLALNATSYSEITQTIKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDN8</accession>
    <name>A0A0D2UDN8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347810.1">
        <property type="nucleotide sequence ID" value="XM_004347760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDN8"/>
    <dbReference type="FunCoup" id="A0A0D2UDN8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDN8"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDN8"/>
    <dbReference type="OMA" id="WPYKWEG"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDN8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252719" evidence="11">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="121"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="46773" checksum="F71DD48541F92CE0" modified="2015-04-29" version="1">MKLAAIALLLSACLVATVSATSSALPTRTVSYANQRVLSCEMTSNEGVRLLRNFVDSHRIDIWQDHNPMHIRVTGLQAALVERIPGVVCENYIADLEAAVVAHEAELAAIAAAPTAGWFDAYHPVDDILAYYKNLTVTYPSLISWVPSIGKSTLGKDIPAVHVTSAKGSNKPKFFIQCNIHAREWISSAVCNYLIDFLVKNYNVNSTVAAILDSQELVVIPVLNVDGLAYTYSNDRLWRKNLSTNKGSKCLGTDLNRNYPYHWNNGGSSSNPCDDTYMGTAANSEPETQASVNYFRASAPAIAAIDFHSYSQLVLRPWGDTNTNCQDETRFAKLGTNMVNTIYALTKTTYTSEKSIGLYPTSGTASDFFYADDSNNKGYRAASYTIELRDTGKQGFLLSPTQIVPNGEEILGAFLGFATDIGANPIVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDX7</accession>
    <name>A0A0D2UDX7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate-bisphosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347929.1">
        <property type="nucleotide sequence ID" value="XM_004347879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDX7"/>
    <dbReference type="STRING" id="595528.A0A0D2UDX7"/>
    <dbReference type="eggNOG" id="ENOG502QTHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDX7"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="595" mass="63541" checksum="3E1D72816AAC4A04" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEG9</accession>
    <name>A0A0D2UEG9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348119.1">
        <property type="nucleotide sequence ID" value="XM_004348069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEG9"/>
    <dbReference type="FunCoup" id="A0A0D2UEG9">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UEG9"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEG9"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000003">
        <property type="entry name" value="60S ribosomal protein L10, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="215" mass="24457" checksum="D4DB4E14070B0F28" modified="2015-04-29" version="1">MGRRPARCYRYCKNKPYPKSRFCRGVPEPKIKIFDLGRKKASVDDFPLCIHMLSLEKEQLSSEALEAGRICCNKYISKLSGKDSFHLRVRVHPFHVVRVNKMLTCAGADRLQTGMRNAYGKPMGTVARVDINQILFSVRTKDSNKAVVVEALRRAKFKFNGRQKIIVSNKWGFTNFTRDEYLALRNANRIVPDGAFCKVLNGHGPLKNVKSPVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGL4</accession>
    <name>A0A0D2UGL4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4 gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347649.2">
        <property type="nucleotide sequence ID" value="XM_004347599.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGL4"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGL4"/>
    <dbReference type="OrthoDB" id="10071175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1294" mass="137752" checksum="84AA2DCB968B354C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH03</accession>
    <name>A0A0D2UH03_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346716.2">
        <property type="nucleotide sequence ID" value="XM_004346666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH03"/>
    <dbReference type="InParanoid" id="A0A0D2UH03"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="707" mass="76727" checksum="06A9C6F14C2FDEDC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH95</accession>
    <name>A0A0D2UH95_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346806.1">
        <property type="nucleotide sequence ID" value="XM_004346756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH95"/>
    <dbReference type="FunCoup" id="A0A0D2UH95">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UH95"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UH95"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH95"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="292" mass="31993" checksum="8859DF6A1D83E7CE" modified="2015-04-29" version="1">MFEARLAQSNLMKKILDAIKDLITEANLEISSGGISLQGMDSSHVSLVALLMRSDGFSPFRCDRNLTLGVNLQAMAKLMKCASNDDILTMTAEDNSDTLNLQFESPAQDKLSEFEMKLMDIDSEHLGIPETEYDAVIRMPSSEFQRICRDLGAGIGGESVTIACTKEGVKFSVTGSVGSGSITLKQTGSVDKPAESVVINMAQPVTLIFALRYLNSFAKATPLSESVSLSMSREVPLVVEYKMNDTGYVRFYLAPKLEDEENQETEAEAEDRPNKGSKSKKAKEEDAMEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI66</accession>
    <name>A0A0D2UI66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_009852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UI66"/>
    <dbReference type="eggNOG" id="KOG0194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI66"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268561" description="receptor protein-tyrosine kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1560"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="222"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="424"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="525"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="621"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="927"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1140"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1337"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1452"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1668"/>
            <end position="1876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1876" mass="198223" checksum="6E9A33C574765A8D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMW2</accession>
    <name>A0A0D2UMW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344337.1">
        <property type="nucleotide sequence ID" value="XM_004344287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMW2"/>
    <dbReference type="FunCoup" id="A0A0D2UMW2">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UMW2"/>
    <dbReference type="eggNOG" id="KOG2430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMW2"/>
    <dbReference type="OMA" id="WTIALVD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252769" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="707"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="817" mass="89693" checksum="A8B7A5CC1760C8E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URG8</accession>
    <name>A0A0D2URG8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URG8"/>
    <dbReference type="FunCoup" id="A0A0D2URG8">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2URG8"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URG8"/>
    <dbReference type="OMA" id="GMATWKP"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URG8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14501">
        <property type="entry name" value="PFA-DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF18">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21064" checksum="8B7215780126AD0A" modified="2015-04-29" version="1">MAQVSPPDVYGIVEPNVYRSNFWHPSNFPFLKSLGLRTLLVLSPDKPLRPIADFCEDNSVNVIHLGLSAWKLDASSWKPVSDELVKEALEITLDVTTHPVMLMCSSGIHQTGTIVGCLRRLQNWNLTSILNEYRLYAGSKSRYTNEQFIELFDLDLVRVPLSPPAWFVQMTEPIEGAVNYNETAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URU0</accession>
    <name>A0A0D2URU0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URU0"/>
    <dbReference type="STRING" id="595528.A0A0D2URU0"/>
    <dbReference type="eggNOG" id="KOG3971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URU0"/>
    <dbReference type="OrthoDB" id="10023951at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="723" mass="74868" checksum="B08EEDD211DC11D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USM0</accession>
    <name>A0A0D2USM0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342627.1">
        <property type="nucleotide sequence ID" value="XM_004342578.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2USM0">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2USM0"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USM0"/>
    <dbReference type="OMA" id="WNYKEAT"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000276">
        <property type="entry name" value="Regulatory-associated protein of mTOR isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="7">
        <location>
            <begin position="726"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1365"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1475"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1575"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="622"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1475"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1577"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2010" mass="219402" checksum="2592BC10395D41EE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USY0</accession>
    <name>A0A0D2USY0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342695.1">
        <property type="nucleotide sequence ID" value="XM_004342646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USY0"/>
    <dbReference type="STRING" id="595528.A0A0D2USY0"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USY0"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USY0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="377" mass="40023" checksum="67ACAD72C0534FA4" modified="2015-04-29" version="1">MSIEQDGVGGGEAGRVAGDLDDKDDDKDDQDQDQDQDDDEDEDEDDDDDDDDDVELNMATSAPGTRPTPAFTRPGAAPVTHTPTTIPTGGVLPPIQPVQPRIAASQLAAQATSNRLDINAVGQYNDKSIFEFDLDGAEDKPWRKPGADISDYFNYGFNEETWQIYCEKQKSMRASVGSSGIGRTVPPLIPQLAGGSDIKPLRPAGYTDSNRISIGRATRRADESALQVLGGDPSGSSIQSLVNLDASSVPALLPLARNMPPVAPPLAPPAAAAPAPLQPLRPAYPVPAPGMVHPAMMQGKMPPPLMMPMMPGMMPPGMMPPGMVPGMMPPGMPRPPWAAQSHGSSSHSSHNSDDSDRSSSKRSSSSEDDSSRKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTR2</accession>
    <name>A0A0D2UTR2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346409">
        <property type="protein sequence ID" value="KJE98381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTR2"/>
    <dbReference type="InParanoid" id="A0A0D2UTR2"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="569" mass="64027" checksum="C789CAD926C36423" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTU5</accession>
    <name>A0A0D2UTU5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346419">
        <property type="protein sequence ID" value="KJE98416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTU5"/>
    <dbReference type="InParanoid" id="A0A0D2UTU5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="105" mass="11696" checksum="9BC8DA1B4375F697" modified="2015-04-29" version="1">MASSIVFSSSDKSELDCGLWIVDCGLRCKIHTLIRIQRALVLSARRASPRTCTHFECLISRQSQRRNEATRPLRPVRLCGFQAQRATLAVGLPQSLPSASSARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFV1</accession>
    <name>A0A0D2VFV1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette sub-family B member 10, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ABC-mitochondrial erythroid protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette transporter 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAOG_000237</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>biliverdin IXalpha(in) + ATP + H2O = biliverdin IXalpha(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:82359"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:82360"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFV1"/>
    <dbReference type="FunCoup" id="A0A0D2VFV1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFV1"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFV1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000048">
        <property type="entry name" value="ATP-binding cassette sub-family B member 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="23">
        <location>
            <begin position="145"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="465"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJE88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="708" mass="76023" checksum="D80FF5821FD4BF33" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH72</accession>
    <name>A0A0D2VH72_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365659.1">
        <property type="nucleotide sequence ID" value="XM_004365602.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH72"/>
    <dbReference type="STRING" id="595528.A0A0D2VH72"/>
    <dbReference type="eggNOG" id="ENOG502R79J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH72"/>
    <dbReference type="OMA" id="DWRLDYC"/>
    <dbReference type="OrthoDB" id="1917519at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04751">
        <property type="entry name" value="Commd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037355">
        <property type="entry name" value="COMMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="195" mass="20700" checksum="462DEE7B2E895817" modified="2015-04-29" version="1">MELPASVTGGLGLLGNKAHFATPAAGVALTKAAVSVLLKVTTEAEAVDGEAALKGVDRATLKQAYAALVSLLLEAAKHNKTEADVKAALEDAKVSEDRAGPIAAVYAAEIVELRTVLSSTGFGFPHVVDADWRLDYYMKDNQLEKVNQPVYLIRLKTEQNGGKGPDVQFSASLEELQDLVNTLKDASRNLKPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHX1</accession>
    <name>A0A0D2VHX1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UVR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365857.1">
        <property type="nucleotide sequence ID" value="XM_004365800.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHX1"/>
    <dbReference type="FunCoup" id="A0A0D2VHX1">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VHX1"/>
    <dbReference type="eggNOG" id="KOG2025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHX1"/>
    <dbReference type="OMA" id="NHQKNFV"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="10">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1174" mass="126960" checksum="5FDC0C19FC9FD8B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIC2</accession>
    <name>A0A0D2VIC2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIC2"/>
    <dbReference type="InParanoid" id="A0A0D2VIC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="232" mass="23771" checksum="22A3305EC4ECB65B" modified="2015-04-29" version="1">MANLDNRSKQAMTLPAFARMASKLPPGKLATTVSSKPEAASAASSSGGRRRRSSMVVFDESQSPTQQVAAAAAVMSTLASNNMAQAFTPGGHRIEGNLPISQSPLHHLSSSLESSALAGIASDLPATAAIPSSVQGQRGLGSSAILRSVKLAGRRAPHAADPLESGSTPSSSAEPDGALERLRLAAKRTWEAPETANAKNPLETENQRGHAATSSSSPSGSPTVASTNKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKA4</accession>
    <name>A0A0D2VKA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol carrier protein 2</fullName>
            <ecNumber evidence="13">2.3.1.155</ecNumber>
            <ecNumber evidence="14">2.3.1.16</ecNumber>
            <ecNumber evidence="3">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="ORF">CAOG_001759</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="41">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="27">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="13"/>
    <dbReference type="EC" id="2.3.1.16" evidence="14"/>
    <dbReference type="EC" id="2.3.1.176" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKA4"/>
    <dbReference type="STRING" id="595528.A0A0D2VKA4"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKA4"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="37">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="39">
        <location>
            <begin position="284"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="38">
        <location>
            <begin position="471"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KJE90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="575" mass="60680" checksum="916466FC20CD8237" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKG3</accession>
    <name>A0A0D2VKG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364685.1">
        <property type="nucleotide sequence ID" value="XM_004364628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKG3"/>
    <dbReference type="STRING" id="595528.A0A0D2VKG3"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKG3"/>
    <dbReference type="OMA" id="MRDEANF"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="4">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="35072" checksum="9A97CF175C23A6B7" modified="2015-04-29" version="1">MSTTAAAAAPPAPKANKPKKVPIHPPYNVMVLEAIKELGDRSGSSRQAISKFISDKYPSTADTINHQLPAALTRLADAATISRVSGIGATGSFRASKTAAGAAKAVKAAKAAKAAGAKTAKAPKAPKAPKAPKAPKDAAAAKVAKAPKASKAADAAKLPKAPKAPKTDKPAKAPKKEGKAAAKTSNAAIAAKKKAVKAVTPANPAVAAAALAAAAALPKAAKAPKAAKAPKAEKPAKAAKAPKADKPAKAAKAPKAAKAEKPAKAPKAPKAEKPAKAPKAAKAEKPAKAPKAEKPAKAPKADKPAKAAKAPKADKPAKIAKAPKADKPKPAAKEVKPKAATAKPKAAAAPKPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLA7</accession>
    <name>A0A0D2VLA7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-depolymerizing factor ADF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348877.1">
        <property type="nucleotide sequence ID" value="XM_004348827.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLA7"/>
    <dbReference type="FunCoup" id="A0A0D2VLA7">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLA7"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLA7"/>
    <dbReference type="OMA" id="QCRFAVY"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="15823" checksum="895D2AEB71DA90D1" modified="2015-04-29" version="1">MASGVKVDPEVATVFQDLKLKHTYRYVIFQLNSDNTMIVITKKADPSATYDEFLAELPPNDCRYAVYDLAYDTPESGKREKLVFFAWAPNESKIKQKMLYASSKDALKAGLVGLHAEIQATDASEVDYSYIIEKLSSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMH4</accession>
    <name>A0A0D2VMH4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Exodeoxyribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMH4"/>
    <dbReference type="FunCoup" id="A0A0D2VMH4">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMH4"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMH4"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMH4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="11">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="571" mass="63516" checksum="46BDF16E0BB308EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN70</accession>
    <name>A0A0D2VN70_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN70"/>
    <dbReference type="STRING" id="595528.A0A0D2VN70"/>
    <dbReference type="InParanoid" id="A0A0D2VN70"/>
    <dbReference type="OrthoDB" id="15153at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049165">
        <property type="entry name" value="GH39_as"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF10">
        <property type="entry name" value="BETA-XYLOSIDASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253732" evidence="5">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="6">
        <location>
            <begin position="25"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="464" mass="51654" checksum="C169F67F09F2F8AF" modified="2015-04-29" version="1">MRTSLLAVFCVTVAAALAVATGQSAARFEDWRQAVRESQSALGWEYIRFHGVLNDDMSVVIAPNEYSFFNIDQVYDFLLSINMRPIVELSFMPTAYASGNETIFYYKGNITPPKDYAQWDDLITKLAQHLVDRYGLEEVSQWYFEVWNEPNCGFWSGNQTDYFTLLQHTYTALKSVSPLIRVGGPATCQSQWIAETVAFCKQNGIQLDFISTHEYPTDPTTYPVRDLMHDIFAATKAAAGGIPVIYTEFNSGLFSDTPNHDLPYAASFLVNMVAKTQGLVEIASYWAVSDVFEEGGQDPTPFHDMYGIVTNIGVPKPAFHGLKLLRQAGTDRVAVSTVGDANTTSVWATRTDNEVQVFITNFDYFEFPIQNYTVTVTVAGVAAKGSPVNSLYYLIDDTHVNPRAVWEAMGSPTYPTPAQIVALHEASTLHAQQLPYSVVGSDITFTFNLVPYSTVAVFIPLQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQQ4</accession>
    <name>A0A0D2VQQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363626.1">
        <property type="nucleotide sequence ID" value="XM_004363569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQQ4"/>
    <dbReference type="InParanoid" id="A0A0D2VQQ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="112" mass="12307" checksum="FC072CD8EDF0BC84" modified="2015-04-29" version="1">MSTQELRQRRSNDTSDGDSASVDVARLAFSADELVRRAAWDAAADRREDTVKRAWRQFATDPRVIAFILFAIVVYLVMSALRDPSLSSSSSYASGAARSGSGPEVQHFARQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR05</accession>
    <name>A0A0D2VR05_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR05"/>
    <dbReference type="STRING" id="595528.A0A0D2VR05"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VR05"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR05"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="36252" checksum="FAC7EA11585E1A03" modified="2015-04-29" version="1">MGRGEFKRRKTWRHTPKESSASRNSARLGARPLVPLFMSFDSNTNHTDAISLVAFCQQWPFAALTSLAARAQLQAARLHDLASKSNGALRVIKYREDVVELLEKRRDNQKMVGGFLGIEGAHALDGDFSNVDRLYEYGFRVIGPSHFFDNELAGSAHGVERYGLTEFGKKCIRRMEELGIFVDLAHASQAVISDVLAMATRPVVVTHGGVQGFCNTSRTLSDDQLRAIAKTGGVVGIAYFEHCTCGQTVNEIALSIKYAIDLIGAKHVALGSDYDGSVVVPFDTTQLIQLTDALLKLNISKEDIRLVMGESTIQLLRDYLPSRIPGAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRG4</accession>
    <name>A0A0D2VRG4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348070.1">
        <property type="nucleotide sequence ID" value="XM_004348020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRG4"/>
    <dbReference type="FunCoup" id="A0A0D2VRG4">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRG4"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRG4"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="60"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="397" mass="43967" checksum="134B6FE74F2DC607" modified="2015-04-29" version="1">MARSGLIPKSKTNHRQKRNAMPRDPAAAFASGSSGVRKAKTRRGKRILEDRAPKIEENPKSSLFVRGGNTSEVITNCLREFSLLRKPHTINLRRKNPIHPFEDATFVESFSKKYDASLFAFGNHSKKRPHNLILGRTFDHQLLDMIEFGVQDFKSLSDFKNEKSVQGSKPCLFFAGDGFEQLPELKHVKNLLADFFRGPVVDKIALAGLDHVITFVALSDKSILLNHHRIVLKKSGTRLPRVELEEIGPSMTLEIRRTQLASDDLRRDALRVPKQLKPTKVKNIEYDSLGNKLGRVHIAQPDLAELQTRKMKGLKRSHAQADADDDDDDGVDASQPEPVQPRALPAAAAAPAHSPKRARADSDAAPAPKVASPAIKAAASPKISPRVTRSKAKVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRN0</accession>
    <name>A0A0D2VRN0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348142.1">
        <property type="nucleotide sequence ID" value="XM_004348092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRN0"/>
    <dbReference type="InParanoid" id="A0A0D2VRN0"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="50438" checksum="78CC7ABA2B468940" modified="2015-04-29" version="1">MSPQRMQQQDEAHEDDVAHRPIPAAWFDVDEPLFDRSFRASGEAGAANFTADELDGDDEATRLKQSNASSSSSSSTAAAGSTLLTRAQQKELADAEMCKQRKQIMDRYFGRTSAPWDTMPDSLKQRPVGDLTKVLPVELLFIIFRSLDTQSLARCSQVCKSWQRLIDADVCGLRLWQLKQNSTQCDREAKPPCCLTISHSMPRHSAKSVYALSPDRSSALGRDWSAGFAALSTAAPSIPLPSHYESHQPYCIAFDRVTQSLVNERILSSVAPDLEAGTETQVERLRASALSKRTVACIYDTQTRWAAGMLFSVAKRQVSEDTSRPQTPAPIEHRDLFTDDTWAQTSCSRIPYIGSGFNTPEGCASPPALLESSRVTRPYPADDEDVPPPPQVRQNLHLTLAASRSHSSAPSAHPPATATRVAPPPQSAQPSGQTSLQLEMFPVGASLNLDVSVWGELLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTS9</accession>
    <name>A0A0D2VTS9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polypyrimidine tract-binding protein PTB-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTS9"/>
    <dbReference type="STRING" id="595528.A0A0D2VTS9"/>
    <dbReference type="eggNOG" id="KOG1190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTS9"/>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12693">
        <property type="entry name" value="RRM2_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12423">
        <property type="entry name" value="RRM3_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000341">
        <property type="entry name" value="Hephaestus, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="341"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="460"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="537" mass="58187" checksum="5505EF6F36368D6E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY95</accession>
    <name>A0A0D2VY95_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose/Sorbosone dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VY95"/>
    <dbReference type="eggNOG" id="ENOG502QQKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VY95"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY95"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039991">
        <property type="entry name" value="SHOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF75">
        <property type="entry name" value="ALDOSE SUGAR DEHYDROGENASE YLII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17825">
        <property type="entry name" value="DUF5587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1459" mass="156244" checksum="B1ECC1DB4006F7E5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYI2</accession>
    <name>A0A0D2VYI2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343776.1">
        <property type="nucleotide sequence ID" value="XM_004343726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYI2"/>
    <dbReference type="STRING" id="595528.A0A0D2VYI2"/>
    <dbReference type="eggNOG" id="ENOG502SAF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYI2"/>
    <dbReference type="OMA" id="KSHWFER"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="933" mass="99486" checksum="A4C8358857507EFC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0T0</accession>
    <name>A0A0D2W0T0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0T0"/>
    <dbReference type="eggNOG" id="KOG1044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0T0"/>
    <dbReference type="OMA" id="KSLNKMW"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0T0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF17">
        <property type="entry name" value="DEMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34593" checksum="1CA1FB619E2F8532" modified="2015-04-29" version="1">MKWIVVAVEFTQKCQKCHTDVDGDGLKLENGKMFHNHCLTCAECSKSLDGAFYDRDGSYYCPADYVRKFGKYCAKCKLLIDNEGILVSGQDFHASCFTCTHCSNVIKPGDTIVYKNGAPLCSHCGSQCCSSCDLVITSDYLTAFDRKFHSTCFRCAECGCALGTNKFVEFNGKPFCEADIPKVQQAHHDADTDCACCRRPIGQNEAIKALDQHFHSSCFRCDVCKCELSGSFYERNGKNYCERDYQSNHGVSCSHCNLQINGVYLQLEDNKSFHTGCIRCQTCQSPFSEGDKIYLREQKPYCEAHQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1J2</accession>
    <name>A0A0D2W1J2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1J2"/>
    <dbReference type="STRING" id="595528.A0A0D2W1J2"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1J2"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1J2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254658" evidence="7">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE98172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="411" mass="43806" checksum="4D4028D1BD34EE64" modified="2015-04-29" version="1">MQVGSVVLQMIASHLLLRSAPALFGRARAALAAMSATATAATTAATAATAATATTGATIAAPVAAFMSTGAAAGESSVADKYRLKIEQRKRELAAQQQQQQANGQQASAQPTAADAQSQQQLAWEKAEAEIVRFFERTQPGYEAAYKEIQAKEAEFARAEAARQAANDLVAPTAAAATSTSAPTPTPSATPSAKALSPEAQAEAIKKAPFLPSYMQPLSSLIPADVIANGSRSDIIAAWNAAHLGKPDHFASVMPAEAYRRLTSRSRRNSRFVLPVPRGEGFEWMVAEFTNASLLFTSLLDYQTHQEHASSLLSVTFFTDGVLEKHGIALQRAYADHKKLPRELAESLLRNIAHVYLAPGSTGAVSNIALARRGQGAEGLYGFVETFNQQPKQFDFNILLDELKARGLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W222</accession>
    <name>A0A0D2W222_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346416">
        <property type="protein sequence ID" value="KJE98407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W222"/>
    <dbReference type="InParanoid" id="A0A0D2W222"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="81" mass="7906" checksum="21D5CABF36E6F9EA" modified="2015-04-29" version="1" fragment="single">MSDQKEELPTVGSVPHLASTSTGASTSASSSSSSSTASSSSSDVVKAAVADAVAQAAEHPPMSAEQAATQPSSLANLSQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGE0</accession>
    <name>A0A0D2WGE0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365000.1">
        <property type="nucleotide sequence ID" value="XM_004364943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGE0"/>
    <dbReference type="FunCoup" id="A0A0D2WGE0">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGE0"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGE0"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="178" mass="19652" checksum="5905A3F01BF3EE4C" modified="2015-04-29" version="1">MCMILVLILGDLHIPHRTADLPAKFKALLGPGKIQHILCTGNLCSKDSFDYLKSLASDVHVVKGDFDEVVTVGQFKIGLCHGHQIVPWGDVESLSLLQRQLDVDILITGHTHKFASFEREGKFFINPGSATGAFTPLDSEINPSFALMDIQGANVVVYVYTLRGEEVKVEKLDYKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHZ5</accession>
    <name>A0A0D2WHZ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein-PA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365719.2">
        <property type="nucleotide sequence ID" value="XM_004365662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHZ5"/>
    <dbReference type="FunCoup" id="A0A0D2WHZ5">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHZ5"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHZ5"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHZ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="669" mass="71737" checksum="7B632D93A96DD3F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI27</accession>
    <name>A0A0D2WI27_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI27"/>
    <dbReference type="InParanoid" id="A0A0D2WI27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="11858" checksum="96AD97AF8EFA7092" modified="2015-04-29" version="1">MAKSVNNQCTVCFELAEESSQSQNAEHKANSASRAVVVFRPWCCSTEVYDWLLSCCLSESQICSKRCKRAFFRRFRFRLNNSPAPPSRPRLDLTFDCKNLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIG3</accession>
    <name>A0A0D2WIG3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365274.1">
        <property type="nucleotide sequence ID" value="XM_004365217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIG3"/>
    <dbReference type="InParanoid" id="A0A0D2WIG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="224" mass="25146" checksum="6B7A0486568697A6" modified="2015-04-29" version="1">MSGADKLREQAIFSIGLLKAPTSRYLSRRDRDLVVQTINELMSAWKLAERPPEQEKVSACQADERTAEENQLNLEASIPNWKRSHFNHAPDRITTEMDHCAPHVSDTVQVDAWSFVVGFYSYDDLQSLYSKPECHPDIYHEDGGIAMHWPSIGAIVEFEASGEVGASLVRLPSKSEQLIIPKQNRTNTVNQLLSFISPQLLQHGAAVLDKLRVQASKSPAIKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIV3</accession>
    <name>A0A0D2WIV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349794.2">
        <property type="nucleotide sequence ID" value="XM_004349744.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIV3"/>
    <dbReference type="STRING" id="595528.A0A0D2WIV3"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIV3"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="38"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="455"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="831" mass="90649" checksum="B2A37CA9CA7ED376" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJZ0</accession>
    <name>A0A0D2WJZ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364648.1">
        <property type="nucleotide sequence ID" value="XM_004364591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJZ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WJZ0"/>
    <dbReference type="eggNOG" id="ENOG502QPJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJZ0"/>
    <dbReference type="OMA" id="ECCSYMS"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255015" evidence="2">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="524" mass="58391" checksum="AF01E06A1FAD703E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK92</accession>
    <name>A0A0D2WK92_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349893.1">
        <property type="nucleotide sequence ID" value="XM_004349843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK92"/>
    <dbReference type="STRING" id="595528.A0A0D2WK92"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK92"/>
    <dbReference type="OMA" id="VGVPPWR"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="322" mass="35271" checksum="5D0515BA93DB85BA" modified="2015-04-29" version="1">MLSHQVIAAAANVTASSAVADAGAVYVLHGILGCARNWSAFSKRIASLGRGWDKLPFVLVDQRCHDASRDFAQTSGRPNTIDSCAQDLAELAVKSGRAPAVIIGHSMGGKVAMRFQQLFPDLCKQFWILDAMPGLGAPIAKDTTPEPDSSQRLFAFVEHHPGPFPSRKAVHSLAQEFGFSHSTAAWLTSRTVRQKHNVVGSNDHVVGWGFDVHGVQELRHSYMELDVWNVLDAPLPPASGSPATVDFVYGAQSKRWNDVLLSRLLSTDSMQRQDGHESVADTHNTVRVHRLDRAGHWLHADNPDGLLQIFQRFPPRLSSDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKS7</accession>
    <name>A0A0D2WKS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348929.1">
        <property type="nucleotide sequence ID" value="XM_004348879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKS7"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKS7"/>
    <dbReference type="OMA" id="YALIYYA"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="246" mass="26803" checksum="0631E6B707CCD048" modified="2015-04-29" version="1">MSSSQHPVAACLAYLEANGLQSTVTERLGECWLLLVARTLSMSVIAICIFLKLPQAQTILRARSAEGINVPSLLLEILGYSSVITFGWRKELSITVYGELILLLLQDYLVLALILHYTKRFTPNVYASIVLYFAVFFAFLLGYGPVVVVQVLQSSAILISAASKLLQISANIKNQGTGRLSLATLALNTYASYARLTSILIEVDSIAYAISGIISSTLNTVLTLQVIYYAKATIQRPSTTETAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL57</accession>
    <name>A0A0D2WL57_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL57"/>
    <dbReference type="FunCoup" id="A0A0D2WL57">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL57"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL57"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL57"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="24108" checksum="702A29D6016E75D9" modified="2015-04-29" version="1">MKSALRRSCTPTLRPFLALARVQAIRVQHEPVTLKQRGGGKRKAEGQPRVLSPARSMCATVFSSCAGAPASPAIDSTLCKPVELTMLTSTSPDTLGKRSAIEMLTLLRPLLVVLQLRVGDEQSIENATVAIKDEDHTIGNALRYMLMKNPDVEFCGYSIPHPSENKIHVRVQTVPGSGVSAVDVVRKALEQLIEMCSHVAGVVQTEFDLQPPVVAETEEMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM22</accession>
    <name>A0A0D2WM22_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349031.2">
        <property type="nucleotide sequence ID" value="XM_004348981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM22"/>
    <dbReference type="STRING" id="595528.A0A0D2WM22"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM22"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255075" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="75899" checksum="5D62242FA1249172" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM74</accession>
    <name>A0A0D2WM74_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose-regulated protein 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349108.2">
        <property type="nucleotide sequence ID" value="XM_004349058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM74"/>
    <dbReference type="STRING" id="595528.A0A0D2WM74"/>
    <dbReference type="eggNOG" id="KOG0020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM74"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270030" evidence="9">
        <location>
            <begin position="23"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="109"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="816" mass="92394" checksum="BAF122DC05F5F52D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMX1</accession>
    <name>A0A0D2WMX1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364165.1">
        <property type="nucleotide sequence ID" value="XM_004364108.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMX1"/>
    <dbReference type="STRING" id="595528.A0A0D2WMX1"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMX1"/>
    <dbReference type="OMA" id="WIRESGY"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="124"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="400"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="637" mass="68678" checksum="45B08297D5AD64C2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNB4</accession>
    <name>A0A0D2WNB4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363766.1">
        <property type="nucleotide sequence ID" value="XM_004363709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNB4"/>
    <dbReference type="STRING" id="595528.A0A0D2WNB4"/>
    <dbReference type="eggNOG" id="KOG3992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNB4"/>
    <dbReference type="OMA" id="FEWVMRD"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="304" mass="33691" checksum="DE9F8ED3A70E82F0" modified="2015-04-29" version="1">MSATPSVTSILAPDWGEDLSATELIAQEKSNLHKELEWLLRMEVPAVFMQLGLMLKDCAQTLAGPSGVSSAVAQASVFTAPITNTSDSVKGFAMLEGSRIIKADVTVRFSKWNKSLPISTSITSKEPWILSQIQNATNYVQLALSELDDSSLQHGLFHTREQVQSVMDRVMAFLRKAQDQLLFQSNLFPYNIDDLQLNAFNPRLPADLFVDFSINYAALNVSVYACTLLGTNQPARKPSSVARKKADMLIGYVHETPYGTRFEIVDHDEVECPIPSLAQSLAHLKSAYELCQRMKDKVCTLKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WND1</accession>
    <name>A0A0D2WND1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363791.2">
        <property type="nucleotide sequence ID" value="XM_004363734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WND1"/>
    <dbReference type="eggNOG" id="ENOG502QRT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WND1"/>
    <dbReference type="OrthoDB" id="10266452at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="12403" checksum="142E358BC98DE5C6" modified="2015-04-29" version="1">MGKHGRFFQAAIRETEEEAGVHIRLTGILSVQHSPRHGYDRMRVIFLGEPIDPNEPPKSIPDKESDRAEWVSLADLATRKLRGSEPQTWFSYVTQGRHVAPLDMLGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNS3</accession>
    <name>A0A0D2WNS3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Poly [ADP-ribose] polymerase</fullName>
            <ecNumber evidence="15">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_003118</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="15"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363957.1">
        <property type="nucleotide sequence ID" value="XM_004363900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNS3"/>
    <dbReference type="STRING" id="595528.A0A0D2WNS3"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNS3"/>
    <dbReference type="OMA" id="MNFKYKY"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140806">
        <property type="term" value="F:NAD+-protein-aspartate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140807">
        <property type="term" value="F:NAD+-protein-glutamate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08001">
        <property type="entry name" value="WGR_PARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008288">
        <property type="entry name" value="PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08063">
        <property type="entry name" value="Zn_ribbon_PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000489">
        <property type="entry name" value="NAD_ADPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="18">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="22">
        <location>
            <begin position="488"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="21">
        <location>
            <begin position="615"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="20">
        <location>
            <begin position="752"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE92093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="968" mass="106548" checksum="67723B2D4ED9D995" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNW0</accession>
    <name>A0A0D2WNW0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363550.1">
        <property type="nucleotide sequence ID" value="XM_004363493.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNW0"/>
    <dbReference type="InParanoid" id="A0A0D2WNW0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="389" mass="41090" checksum="A0C521338CA3B871" modified="2015-04-29" version="1">MGNVLCCCFDGGDEESDPLLKGSSQSGQKSVASRRRDGTLSPDPRPTSPGTLAQSRIDRDDADDQQHQDDGAEYTEKRLIERAKREQRTNAVLQAKQHQRADRAAALAEERNRKLEQRARRQDDVQRDKDERRKRLGLAPSGFAADNVSIHSEDSVQSFSSTRTTKSTSTSMSRASQRSNASTSALPGSTRISPSNSLLDMESAIPDGMSSAAAGVQSATPVAGGAPVEAADPDAPEVLTIDAGIILDQGDAQATDSKAATETDATEEAALQHDSTLTVDEQLEELQSTLVDPAQEVTLAELAPAPHMLDLAGESAAVDDEARGDSAATTEETVAELQSSLVDPALEVTLSELGHASEESTLAPVDSSAEQEPTAAEEESSEAAEPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP00</accession>
    <name>A0A0D2WP00_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4476 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364108.2">
        <property type="nucleotide sequence ID" value="XM_004364051.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP00"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4476" evidence="2">
        <location>
            <begin position="459"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="553" mass="57622" checksum="DE4D5AAE10E3531C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPF4</accession>
    <name>A0A0D2WPF4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Inorganic phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347884.2">
        <property type="nucleotide sequence ID" value="XM_004347834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPF4"/>
    <dbReference type="FunCoup" id="A0A0D2WPF4">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPF4"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPF4"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPF4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="35949" checksum="AE706F8C75FF9289" modified="2015-04-29" version="1">MSASLFGLPSARKFTMAPAAAESGYSCEFGSAKYYQLCAVGGMLSCGLTHTFVVPLDLVKCRMQVDPVKYKSIGSGFSLTIKEEGLRGLAKGWAPTFIGYSLQGVGKFGFYELFKNIYGNALGEENAYLYRTSLYLASSASAEFFADLALCPFEATKVRIQTQPGWANNLREGLPKLIREEGISGAYKGITPLWGRQIPYTMMKFAAFERTVELLYQYVVPKPRADCTKSEQLAVTFSAGYIAGVFCAVVSHPADSVVSKLNASKGSTALQVAKQLGWAGLWKGLVARIIMVGTLTGLQWFIYDGFKVAAGLPRPPPPQMPESLKKKLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPW0</accession>
    <name>A0A0D2WPW0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363454.1">
        <property type="nucleotide sequence ID" value="XM_004363397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPW0"/>
    <dbReference type="eggNOG" id="ENOG502SDRJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPW0"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="4">
        <location>
            <begin position="327"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="433" mass="46105" checksum="4EEEB1FD1C806C84" modified="2015-04-29" version="1">MSVTGGCSDEWCVVTERNAPEDAVQPQTKVQQQPTHAQPLRGKDDHERNGRDADELEQEPVAMEDDEEAILIYLPGEARRRNTTGGAADDGDDDDDDDDDNGDDDDGDDGVETDPTISASVVLSASAATPLMTEKAARSNTGVTSRSVVVGSLAAAAGIAALQASTLTTAEAAPALQKGAPSAASILGANADSPRNSSANNANNASSSSVAAATAKAVANAAALNAADKAASVAAATIERLTAERDDYCRRYENASRLLSVITNELSDRENERRTLTPAQLIHSWVASQRQKPTFDVDSADCVGRLTAATIDMIRDRNELLRRTIETAQRNDDNRPRLAFSNLTVGDLVVFFPTTHGHYIAFSQQPRYYLSQESIKAFDGSRTSGSRRDYLLGEIIQISEHVADDSSPDGNPYKLPANVRYHTIIAALASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQF9</accession>
    <name>A0A0D2WQF9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQF9"/>
    <dbReference type="InParanoid" id="A0A0D2WQF9"/>
    <dbReference type="OrthoDB" id="6723104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQF9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="702" mass="77391" checksum="853A07667F41BC49" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQQ5</accession>
    <name>A0A0D2WQQ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clint1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQQ5"/>
    <dbReference type="FunCoup" id="A0A0D2WQQ5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQQ5"/>
    <dbReference type="eggNOG" id="KOG2057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQQ5"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16989">
        <property type="entry name" value="ENTH_EpsinR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="584" mass="63060" checksum="5F31C8BB29384259" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQU2</accession>
    <name>A0A0D2WQU2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348056.2">
        <property type="nucleotide sequence ID" value="XM_004348006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQU2"/>
    <dbReference type="STRING" id="595528.A0A0D2WQU2"/>
    <dbReference type="eggNOG" id="ENOG502RS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQU2"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254698" evidence="5">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="79"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="412"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="503" mass="56331" checksum="14D6607237EE84FD" modified="2015-04-29" version="1">MRCAAVLVVVAALAAFASAAPLKMHVSGQRFADEDNRERFFHGMNVVNKVSALMLVLNVPYVPVIDHFDVNFSFSQEDVDVLTGFGLNVIRLSIMMDGAMPAQGAFNETYLSLMQTLIEIAASRDMYVMIETHQDCFSASLCGEGFPTWLAQIAVDPMTPALPLPLAEPYAIDPVTHMPSAADCAKLDWSDYQFTAAQADAYQKLYTVGTPANQGFSDHWRRIVQRFKNNTNVIGYELINEPFAGNIYKNPELMIPSVADRVNLQPFYDNLSNVIREQDPNAIIWFESVTWDDFVPMGFEHPPGGFQYSNQSVISLHYYFGPNVSPMNQFAARYSDAERYGTSLALTEFLIDPSDTPSALEHMSKTMDAADKYQMSWFGWDYKVFEDTTYGPSIWWPTNGTYNWPVVETVARTYPQAVAGKTFHYSYDVATRIFILEYYVNAACKLPTDIFLAEDVHYQNGYTVSVNPSNVVTQSSIKNHVYLTPTSSASNGKFVTVVIGPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS10</accession>
    <name>A0A0D2WS10_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347553.1">
        <property type="nucleotide sequence ID" value="XM_004347503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS10"/>
    <dbReference type="FunCoup" id="A0A0D2WS10">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WS10"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS10"/>
    <dbReference type="OMA" id="KQFAREW"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="539" mass="59090" checksum="866222CAB251C862" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU77</accession>
    <name>A0A0D2WU77_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muskelin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU77"/>
    <dbReference type="FunCoup" id="A0A0D2WU77">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU77"/>
    <dbReference type="eggNOG" id="KOG2437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU77"/>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU77"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="897" mass="99009" checksum="0518850A3D5F48A8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC2</accession>
    <name>A0A0D2WVC2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_007055</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVC2"/>
    <dbReference type="STRING" id="595528.A0A0D2WVC2"/>
    <dbReference type="InParanoid" id="A0A0D2WVC2"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254817" description="RING-type E3 ubiquitin transferase" evidence="16">
        <location>
            <begin position="36"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="SWEET-like" evidence="17">
        <location>
            <begin position="484"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF11145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE96785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="858" mass="94788" checksum="D80B8CA9434890FB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVL9</accession>
    <name>A0A0D2WVL9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343878.2">
        <property type="nucleotide sequence ID" value="XM_004343828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WVL9"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVL9"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF20">
        <property type="entry name" value="LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="64"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="179"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="286"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="434" mass="47306" checksum="D82AF82BB461ED74" modified="2015-04-29" version="1">MLSRVALTCARRLTQSTAASIQQQHQQPRALLSMGASAARAAAGAGSSKQQAYVSPFDERPQLTDEHRIFRDAARRFFETEVAPHHAKWEQDGMVSREVWEKAGAAGLLGTTIPVEYGGGGGDAFHAAIAVEEQLRLQLSGPGFSLHSDIIIPYILHYGSEEQKQKWIPLMCQGKAISAIGMSEPSAGSDLQGIKTTAVRDGDDYVINGSKIFISNGQMADIIVLVAKTDPSKGAHGTSLILVETDRPGFQRGRNLKKLGLKAQDTSELFFDNVRVPASNLLGKENHGFKYLMQELGTERLVIGVLSQASAEGVFADTVKYVNERQAFGKSIASFQNTKFKLAEMKTQLSVGRVFIDRCLELQNQGKLDPVAAAIAKLHAGDMLAKITDECLQLHGGYGFMWEYTAARAYADARVQRIYGGTSEIMKDIISRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVQ6</accession>
    <name>A0A0D2WVQ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344317.1">
        <property type="nucleotide sequence ID" value="XM_004344267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVQ6"/>
    <dbReference type="FunCoup" id="A0A0D2WVQ6">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVQ6"/>
    <dbReference type="eggNOG" id="KOG2623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVQ6"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="13">
        <location>
            <begin position="413"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="53616" checksum="8B5DC2110A0709AE" modified="2015-04-29" version="1">MLVASRSSSRPVLALALSAGRRAAHSAAASSAPILATSLASSTAPGPCALTELQWRGLLHAHTSSFEGLAATLRSPNRACLYAGFDPTADSLHAGNLLVLMGMLHFHRAGHQVIALVGGATGQVGDPSGRQTERSMLAVNTVASNAAGSPTSSPKPVTVVNNLDWYAPMNVLEFVRDVGQHFRMTTMLGKESVKSRLQPQSTSASGTEPAGMSFTEFTYQLFQAYDYYQLHERNQCRLQLGGSDQWGNITAGCDLIRKVTGKEAHGVTMPLVTTSTGEKFGKSMGNAVWMDAAKTTPFEWYQFFLRSEDSQAERYLRYYTFLSLDEITDIARRHAEAPNKRIAQTALADQVTLLVHGREGLAEAHRSTKLLYHRGGSGSGSPNSTNSNEVQATDSSNSPFELTSAEVAALLSAQTPSINVSRSELGQLLLIDALVRLGLTPSKSEAKKLIRNGGVSVNSVKSVNERDVLGENHALKDSNATLLRVGKRAHGLVLWEAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWP4</accession>
    <name>A0A0D2WWP4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007287</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343146.1">
        <property type="nucleotide sequence ID" value="XM_004343096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWP4"/>
    <dbReference type="FunCoup" id="A0A0D2WWP4">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWP4"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWP4"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWP4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="24177" checksum="47531C55EE50D688" modified="2015-04-29" version="1">MRFEADGIDVHHFAELLIPSGIVLNDQIKWISFHSGYDFAYLLKVLTCTALPTEESDFFSLLYLYFPCIYDIKFMMRSCKHLKGGLQDVSDDLEVERYGPQHQAGSDSMLTAFAFFKMRQLFFEDNIDDSKFQGHIYGLGTSYLSKLEGPASSATTPATSGAPYSPSTTPGAGSNGTYAASSALGTPPSNYGLNGGAKPFSNAVPQSPSTVMANNVVNARKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX01</accession>
    <name>A0A0D2WX01_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343530.1">
        <property type="nucleotide sequence ID" value="XM_004343480.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX01"/>
    <dbReference type="FunCoup" id="A0A0D2WX01">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WX01"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX01"/>
    <dbReference type="OMA" id="VQITKLH"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="15466" checksum="61DD636974B290DA" modified="2015-04-29" version="1">MKFNPDVSSSRRKSRKAHFAAPSSVRRILMSAPLSKELRTKHGIRSLPIRKDDEVTVVRGSHKQTTGKVSAVYRRKWVIHLDSLNREKPNGGTVAVGLDPSKVVITKIKTDANRRALLERKAKHAAAAKGKHTQASVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX86</accession>
    <name>A0A0D2WX86_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007844</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX86"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX86"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1361"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1445"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1469"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1625"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1823"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1657"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1823"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1887" mass="201576" checksum="10BA059960CCF465" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXG9</accession>
    <name>A0A0D2WXG9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343173.1">
        <property type="nucleotide sequence ID" value="XM_004343123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXG9"/>
    <dbReference type="FunCoup" id="A0A0D2WXG9">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXG9"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXG9"/>
    <dbReference type="OMA" id="CFVVMHI"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="171"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="381" mass="42369" checksum="3515EDBDDE245596" modified="2015-04-29" version="1">MGDAASSSRASSAAAESAAVAMPADAPEHNQSIPNTHSHAAAGPGQEEEEEACSQTADCLQATANRMPVVFIMLTAIYSYYAFVVVVSIQVVSNVGQQVGYLIAFHLLYALFVWSYLRTFLSKPAPVPATFAVPSTAITVSGTGWRRIVDSMERHHVERVDPFFKTLRPIGERYCFKCEIVRPDRCHHCSLCQRCMLKMDHHCPWVGNCVGFSNYKYFCLVLFYAHLLTLFLTFATLPYLIQFFNSEIDRGSENINIIVLFMIACAFGLGVMALFYMHVALLVRNMTTLESTRIPRLKMATLRKHGFDVGAKQNFIQVFGTNPWLWAFPVYTSIGNGFDFPVCAAANDEETGSASSDQNLIRAPTIRPQPISFGAQMKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXI0</accession>
    <name>A0A0D2WXI0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270857.1">
        <property type="nucleotide sequence ID" value="XM_011272555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXI0"/>
    <dbReference type="InParanoid" id="A0A0D2WXI0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="198" mass="21446" checksum="744E8BA92B6EE7A5" modified="2015-04-29" version="1">MADLDDWESAADAGVFDAPPPAQTSDRATGVPESAWHQDRHEAADDARRAAAHEEQRHERDLRSFQDSQNVAKLAPEVASTLLPYMPAVRIIRKPATVVASEQQRAQAARAASEQSRAASMLMPSERDAAYAAARERILGAAPETRPAVQATPVTLRPREPVAPPQSQLQALPQATRQPRGPSSGSATGFTRRQDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXR0</accession>
    <name>A0A0D2WXR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Generative cell specific-1/HAP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXR0"/>
    <dbReference type="STRING" id="595528.A0A0D2WXR0"/>
    <dbReference type="eggNOG" id="ENOG502QREH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXR0"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="652" mass="71903" checksum="E4F002D93FD8A6CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXX0</accession>
    <name>A0A0D2WXX0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342785.1">
        <property type="nucleotide sequence ID" value="XM_004342736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXX0"/>
    <dbReference type="STRING" id="595528.A0A0D2WXX0"/>
    <dbReference type="eggNOG" id="KOG2336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXX0"/>
    <dbReference type="OMA" id="MNIVKDY"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="412" mass="44331" checksum="13AAA3F77595B7B5" modified="2015-04-29" version="1">MSSTKTEDELRARVAALEQQLAAALGSAQPSTTAGLVKRTKIATMSSEVVDSNPYSRLMALKRMGIVDNYERIRDFTVAIVGVGGVGSVAAEMLTRCGIGKLLLFDYDKVELANMNRLFFRPDQSGFSKVQAAQETLQGINPDVTIETHNYNVTTVANFAHFVGRIKEGSLTGGPVDLVLSCVDNFEARMAINQACNEIGQTWFESGVSENAVSGHIQLLIPGETACFACAPPLVVASGIDEKTLKRDGVCAASLPTTMGIVAGFLIQNTLKYLLKFGTVSRYLGYNAMLDFFPSMEFRPNEQCTNFHCRRQQQLYQEKLALQPKADGAVAAVAEEAVVHEDDFGIELVSDSAEPAVAGHNANAGLVAGVHRAYDAPAPSHHADAAVTSEISEAASLDLEDLQKQFMAMNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X085</accession>
    <name>A0A0D2X085_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X085"/>
    <dbReference type="InParanoid" id="A0A0D2X085"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="11">
        <location>
            <begin position="60"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1244"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1431"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1511"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1511"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1535"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1561"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1594"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1664"/>
            <end position="1676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1676" mass="182390" checksum="1336ABCBA993612B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0B1</accession>
    <name>A0A0D2X0B1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0B1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0B1"/>
    <dbReference type="InParanoid" id="A0A0D2X0B1"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0B1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="6">
        <location>
            <begin position="848"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1170" mass="124903" checksum="2D8E8144D760FA65" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0B3</accession>
    <name>A0A0D2X0B3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0B3"/>
    <dbReference type="FunCoup" id="A0A0D2X0B3">
        <property type="interactions" value="1020"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0B3"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0B3"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0B3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000040">
        <property type="entry name" value="Putative ribosomal RNA methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="11">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="317" mass="34956" checksum="7CA840DD89CA619C" modified="2015-04-29" version="1">MGKSSKDKRDIYYRLAKEEGWRARSAFKLLQLDEEFQLFLNVRRAVDLCAAPGSWSQVLSKKCHHHACIESHTMQKIVAVDLQAMAPLPGVIQIQGDITKESTAQQIVAHFEGELADLVVCDGAPDVTGLHDIDEYIQAQLILAALNITTHVLRPDGVFVAKIFRGKDVSLLYSQLKLFFRNVTCSKPRSSRNSSIEAFVVCRGYSPPVGFVPTMANPLLDQQYDLSFNQLEGVNRIIVPFVACGDLSAYDSDQTYPLSQPGQSEYHLRPATQAPIDPPYKQALLLKRTNMAAPRAASDQPSIGAAAAAAPEPMQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0C3</accession>
    <name>A0A0D2X0C3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365261.1">
        <property type="nucleotide sequence ID" value="XM_004365204.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0C3"/>
    <dbReference type="FunCoup" id="A0A0D2X0C3">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0C3"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0C3"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0C3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="92"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="369"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="881" mass="98320" checksum="113F597EBCEFD588" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F2</accession>
    <name>A0A0D2X0F2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365392.1">
        <property type="nucleotide sequence ID" value="XM_004365335.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F2"/>
    <dbReference type="FunCoup" id="A0A0D2X0F2">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0F2"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0F2"/>
    <dbReference type="OMA" id="FFCEGCF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024639">
        <property type="entry name" value="DNA_pol_e_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12213">
        <property type="entry name" value="Dpoe2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase epsilon subunit B N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="352"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="599" mass="66427" checksum="1C9231F96526862B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F9</accession>
    <name>A0A0D2X0F9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365424.1">
        <property type="nucleotide sequence ID" value="XM_004365367.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F9"/>
    <dbReference type="FunCoup" id="A0A0D2X0F9">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0F9"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0F9"/>
    <dbReference type="OMA" id="VCSIQKA"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="34578" checksum="A9EB5D2E65947FAB" modified="2015-04-29" version="1">MKDTPLSNNERSFVQGAMKSGLRVDGRGVYDFRRIRIAYQPERGHVEVQLGRTRVMVQVSCELTKPFPDRPAEGAVQFNVELSPMASPAFEPGRPSEQAIELSRMVERVVKDSNAIDTTSLCVISGEAVWNIRVDLHALDHDGNLSDALCMAALAGLIHFRKPEVSMPSLSSGDESVAGNLIIHDVREREPLPLSVHHMPLCVTFAFLDDGEHMVVDPTFQEERVAEGYLIVAMNIHREVCAVHKHGSVLLDASQISRCTKIAAIKVAEMTELLQKSIDEEEQLRANRRAGKAPAAAKSNKSTIFEYQGSIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0G8</accession>
    <name>A0A0D2X0G8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365464.1">
        <property type="nucleotide sequence ID" value="XM_004365407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0G8"/>
    <dbReference type="STRING" id="595528.A0A0D2X0G8"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0G8"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="870" mass="92851" checksum="E0142F2D3BAE82B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0L1</accession>
    <name>A0A0D2X0L1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365630.1">
        <property type="nucleotide sequence ID" value="XM_004365573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0L1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0L1"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0L1"/>
    <dbReference type="OMA" id="PCARMER"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="49"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="325"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="567" mass="62621" checksum="9A6C7FD82A8303B6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X126</accession>
    <name>A0A0D2X126_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364317.1">
        <property type="nucleotide sequence ID" value="XM_004364260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X126"/>
    <dbReference type="InParanoid" id="A0A0D2X126"/>
    <dbReference type="OMA" id="TIWTIET"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="976" mass="101108" checksum="9A22858296528E11" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X166</accession>
    <name>A0A0D2X166_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364476.1">
        <property type="nucleotide sequence ID" value="XM_004364419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X166"/>
    <dbReference type="STRING" id="595528.A0A0D2X166"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X166"/>
    <dbReference type="OMA" id="ICHILIM"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X166"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="653" mass="72608" checksum="239334626494C714" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1X5</accession>
    <name>A0A0D2X1X5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349444.1">
        <property type="nucleotide sequence ID" value="XM_004349394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1X5"/>
    <dbReference type="FunCoup" id="A0A0D2X1X5">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1X5"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1X5"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1X5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="149" mass="16941" checksum="D51E475DEDB03E11" modified="2015-04-29" version="1">MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELRDMINEVDTDGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADTDNDGQINYDEFVKMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2X1</accession>
    <name>A0A0D2X2X1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMGC/DYRK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2X1"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2X1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="808"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1617" mass="169172" checksum="BE9E93CEB0A0D51A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X390</accession>
    <name>A0A0D2X390_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X390"/>
    <dbReference type="STRING" id="595528.A0A0D2X390"/>
    <dbReference type="InParanoid" id="A0A0D2X390"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="517" mass="58703" checksum="D6423045C26538EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3B5</accession>
    <name>A0A0D2X3B5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347468.2">
        <property type="nucleotide sequence ID" value="XM_004347418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3B5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3B5"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3B5"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3B5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19814">
        <property type="entry name" value="Bbox1_RNF207-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19774">
        <property type="entry name" value="Bbox2_TRIM23_C-IX_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039320">
        <property type="entry name" value="RNF207"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113518" checksum="A44E313058F6ACFE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3P2</accession>
    <name>A0A0D2X3P2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3P2"/>
    <dbReference type="STRING" id="595528.A0A0D2X3P2"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3P2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3P2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="137"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="715" mass="78380" checksum="8F83C1CF5179264D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3T5</accession>
    <name>A0A0D2X3T5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3T5"/>
    <dbReference type="InParanoid" id="A0A0D2X3T5"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3T5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2 4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="7">
        <location>
            <begin position="249"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="756"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1323"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="915"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1343" mass="145779" checksum="5460B6E9F79F78F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X451</accession>
    <name>A0A0D2X451_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345489.1">
        <property type="nucleotide sequence ID" value="XM_004345439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X451"/>
    <dbReference type="STRING" id="595528.A0A0D2X451"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X451"/>
    <dbReference type="OMA" id="QEEWQSE"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X451"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="640" mass="66541" checksum="4BD842742EA4B39C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X465</accession>
    <name>A0A0D2X465_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein wrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345558.1">
        <property type="nucleotide sequence ID" value="XM_004345508.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X465"/>
    <dbReference type="FunCoup" id="A0A0D2X465">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X465"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X465"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X465"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="208" mass="21881" checksum="F886CA39E4570744" modified="2015-04-29" version="1">MVKVFVIYYSTYGHVAKLADTIAKSAATVAGVDVKLWQVAETLSDDILGKMHAPAKKAEVPVIQAADLAEADAFLIGFPTRYGAFPSQVKALFDATGGLWSKGALVGKPFGFFTSTGNLGGGQETTIQSALSFVVHHGGIFVPVGYTSPLLFDNSEPRGGSPWGPGTFTNGDGSRQPSEKELQITTEFGVHFSKIARDLAAGRAANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X499</accession>
    <name>A0A0D2X499_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345706.1">
        <property type="nucleotide sequence ID" value="XM_004345656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X499"/>
    <dbReference type="STRING" id="595528.A0A0D2X499"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X499"/>
    <dbReference type="OMA" id="KITRFNH"/>
    <dbReference type="OrthoDB" id="10261013at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X499"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="89106" checksum="F6829FD78C5854E2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4G1</accession>
    <name>A0A0D2X4G1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345124.2">
        <property type="nucleotide sequence ID" value="XM_004345074.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4G1"/>
    <dbReference type="FunCoup" id="A0A0D2X4G1">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4G1"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4G1"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4G1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="302" mass="33757" checksum="7D93286C7E9DCADB" modified="2015-04-29" version="1">MVKQQSVSQMKARLSELRKTNQRQSELVLELAEAIQSGQGARSLAAAFSDEAERWDVLEQVARAAMDCGRARPTRGEEESLAATLVKQLAARFPESNRVKLLQGELFEAQGDWAGATQLYDELLTETPNHAAATKRKAVIFKSRGDIPKAISVLAAYVQQAMADYEAWVELSELYLSRGDFQRAAFCFEELILSNPLSPVYHIRYAETLYTMGSLENLQLARKHYANACKIQPDDARSLLGLYMTCSALNSEKFIKQRTPINEELEAFAVSRLKQLYSKQASAPQLECLNETFSKMALTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4N9</accession>
    <name>A0A0D2X4N9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006722</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="13"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344343.1">
        <property type="nucleotide sequence ID" value="XM_004344293.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4N9"/>
    <dbReference type="FunCoup" id="A0A0D2X4N9">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4N9"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4N9"/>
    <dbReference type="OMA" id="IQERWCC"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4N9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000019">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="101"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="349"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="863"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="876"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE96389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122371" checksum="2E1D4CE47B704A28" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4R3</accession>
    <name>A0A0D2X4R3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344444.1">
        <property type="nucleotide sequence ID" value="XM_004344394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4R3"/>
    <dbReference type="STRING" id="595528.A0A0D2X4R3"/>
    <dbReference type="eggNOG" id="KOG0811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4R3"/>
    <dbReference type="OMA" id="NEMAGIL"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="418" mass="45906" checksum="54DEDB84A8753E17" modified="2015-04-29" version="1">MSFADSINSASGTRLVRKRQPGTQGSPGSSVRSSLSNGSSSALAADHGADDDRARLLNLVDQSGDGELSPSVRAERTLQQVIADVKSVEAGIVIAIAKLQTHCSNITSLQNQLMGSSVDTFQELTLEREQAASTFNHLRSLFAELTQLQQLVPEHLQSWLQARFQPLFIDYGFVVSEFELLCFPYSDQYSNTRLDRENSLDLSSVTTSAERTELIENKQREQELDRSRRRDEIVHQLEQMAEDERQVLDSRNPLIEEQLRQRRARQEQLERELMELNSMFFDLQHFVQKSASVVTRLEQQVEETKSQVAAGTKELSKAAKIQAVMYPLLFGIVGGAIAGPVGLVAGLKGGGLMSAAALGAGVGAGAGVGVKALRDKFVDQHTPKQSHPSQIAMVNEMAGILIEESPTRPALTVHEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4V5</accession>
    <name>A0A0D2X4V5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343719.1">
        <property type="nucleotide sequence ID" value="XM_004343669.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X4V5">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4V5"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4V5"/>
    <dbReference type="OMA" id="HEIFHKN"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4V5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="847"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1419" mass="155810" checksum="75C98FE30EC9BD7D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X596</accession>
    <name>A0A0D2X596_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007286</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343145.1">
        <property type="nucleotide sequence ID" value="XM_004343095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X596"/>
    <dbReference type="FunCoup" id="A0A0D2X596">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X596"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X596"/>
    <dbReference type="OMA" id="HIREVWS"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X596"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="34613" checksum="473701DC6A44D53D" modified="2015-04-29" version="1">MITDENRDTEFPGVVVKPVGNFRSQAEFTFQTLRCNVDRLKLIQLGITFTDEHGNTPKDVCTWQFNFKFSLSEDTYAQDSIDLLTRSGINFMRFEADGIDVHHFAELLIPSGIVLNDQIKWISFHSGYDFAYLLKVLTCTALPTEESDFFSLLYLYFPCIYDIKFMMRSCKHLKGGLQDVSDDLEVERYGPQHQAGSDSMLTAFAFFKMRQLFFEDNIDDSKFQGHIYGLGTSYLSKLEGPASSATTPATSGAPYSPSTTPGAGSNGTYAASSAPGTPPSNYGLNGGAKPFSNAVPQSPSTVMANNVVNARKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U259</accession>
    <name>A0A0D2U259_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U259"/>
    <dbReference type="STRING" id="595528.A0A0D2U259"/>
    <dbReference type="eggNOG" id="KOG3160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U259"/>
    <dbReference type="OMA" id="CQLYKGV"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U259"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253089" description="Gamma-interferon-inducible lysosomal thiol reductase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24362" checksum="F79AEB71F6AB4A01" modified="2015-04-29" version="1">MRSSVALFALVALLGFAAAGASAMPAHKFHHRPVHHNGDADTAAYPLVEITLYMESLCPDCQALIAGDLWNVWNSSISSIMNLTLVPYGNAQEWQSGSTWEFECQHGARECIGNVLETCAINLLQNSTVWFPFIHCLEGTFNPWSAGNQCAAYFGIDYAPIYACMNSAQGNAMQHEMALKTAALVPAHTYVPWITLNGAHCVPCENGHLKQAICGAYTGPKPADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3I5</accession>
    <name>A0A0D2U3I5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_009392</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3I5"/>
    <dbReference type="FunCoup" id="A0A0D2U3I5">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3I5"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3I5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3I5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="519"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="722"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="879"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="950" mass="101146" checksum="78BC469FC963A837" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4X7</accession>
    <name>A0A0D2U4X7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364420.1">
        <property type="nucleotide sequence ID" value="XM_004364363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4X7"/>
    <dbReference type="STRING" id="595528.A0A0D2U4X7"/>
    <dbReference type="eggNOG" id="KOG0135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4X7"/>
    <dbReference type="OMA" id="CQNVRIA"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4X7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="217"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="14">
        <location>
            <begin position="446"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="12">
        <location>
            <begin position="605"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="777" mass="84110" checksum="A5C70604E1B2CBE7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U511</accession>
    <name>A0A0D2U511_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364453.1">
        <property type="nucleotide sequence ID" value="XM_004364396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U511"/>
    <dbReference type="STRING" id="595528.A0A0D2U511"/>
    <dbReference type="eggNOG" id="ENOG502S7QK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U511"/>
    <dbReference type="OrthoDB" id="2124009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U511"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="155"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="35539" checksum="B59F9A365DD9C020" modified="2015-04-29" version="1">MNYAAALRQNFTIAVAQQWDLNELRASHGLGSSLQSLRESLMTVNGQLAPLNWHKDQEVIIVVIGFYVNDFWRGELGLSRDVDTTPLLEHVRNGDSQAFEMILPPAEGQTRTWQKVHNFYATAHALLHDNLEVPMSEALSAQVQEIRRQLRDRPFDASLARDVHRIVMHDCMDYAGEYRTIQVQPLNSNVAYATPSKISQRLDALFAITQELMPATVTTTELFDQAIKVAGVFFREFLLIHPFRNGNGRVARLLLSYLLRATTAVPVSLFINNRAEYIEVLENCPAEKVPWACIGYILRCCLHQASQMHYLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAR8</accession>
    <name>A0A0D2UAR8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAR8"/>
    <dbReference type="STRING" id="595528.A0A0D2UAR8"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAR8"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="91"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="336"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="557"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="646" mass="73411" checksum="21D739513E0C802E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCN0</accession>
    <name>A0A0D2UCN0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad54b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCN0"/>
    <dbReference type="STRING" id="595528.A0A0D2UCN0"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCN0"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="346"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="682"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="998" mass="108507" checksum="722DE319E98656FE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEL8</accession>
    <name>A0A0D2UEL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrrolidone-carboxylate peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348153.1">
        <property type="nucleotide sequence ID" value="XM_004348103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEL8"/>
    <dbReference type="STRING" id="595528.A0A0D2UEL8"/>
    <dbReference type="eggNOG" id="ENOG502SFAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEL8"/>
    <dbReference type="OMA" id="HEMRVAF"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252555" description="Pyrrolidone-carboxylate peptidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30627" checksum="A2F2684DFCC83E54" modified="2015-04-29" version="1">MKLVLVVIAAVITLALNPGAATAASLHGMLPQRQAADPPGAFQVLLTGFGPFMNYTTNPSQLVAEALHDQCAQFRADNVVKHDYAVCFRTMVLPVADNGSVAVASYLSKFTEATADRIPYDVIIHMGLEDAAKGLLFETIGFNQRANASTPGPIQPGGPTLLPTTVNLGHVRIPELYSLAERRLGRPLATDAALKVNPTRFSANDTTEAWSRDAGTFYCNETLYRTLYQLRSRNLCRSPAFALIPAMFVHLPELTVMSTDAASSLITELAGKLALPLAQGVCSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFB1</accession>
    <name>A0A0D2UFB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAM72A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347291.1">
        <property type="nucleotide sequence ID" value="XM_004347241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFB1"/>
    <dbReference type="STRING" id="595528.A0A0D2UFB1"/>
    <dbReference type="eggNOG" id="ENOG502S1HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFB1"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="360" mass="39206" checksum="0DCA2598F760F72B" modified="2015-04-29" version="1">MPTRYRPARTRLARLPQPSTPCSNGGVADETSLQPHMRRHLEHQEHWWSGVSAWQQQQQQQHTIGRDVLSSSVTNQQARQEPSPRARATPAPASVAENEDSARQGRSSDVTGHAHAAAAAEERGDDSRNQSHNLSTPTAVTLSSSVLARRRNARASLFDLDRQPSSPDAMALSQPTPRRWLQLERATRTRRTSTNNATNVSSAETTSSSPTIFSSELVVQLDCLYCSANITNRGMGGKLRAEPCNQELYSTDAEPSSVALIGNARHAPTCRCLVRDAACLTCGNAVGYHVETPCTRCLGDCTNGHMWIFHSQCTIATIRQAPGQPAAMVWGRLPSPMQDPLLQLAAQPDAPATYSAKPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGQ4</accession>
    <name>A0A0D2UGQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347686.1">
        <property type="nucleotide sequence ID" value="XM_004347636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGQ4"/>
    <dbReference type="STRING" id="595528.A0A0D2UGQ4"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGQ4"/>
    <dbReference type="OMA" id="MAVTHQL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGQ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="396" mass="41959" checksum="4E29353C03D074A1" modified="2015-04-29" version="1">MSATQKQQHHVVIVGMQFAGSAVLKALIKNPQVRITIVDSKDYFDLNLATPRVLVQPAIAEATLLPHATWIANLAPQFAGRVSFVHARMTRVASTAITVQLVATQALQDIAFDFLVLATGLGADYTNSLFKATRLDETSAKRVAALQSHNARLLPAKKILVVGGGAVGVEVAAEIATDYPDKTVTLVHSGSELVKLDPKSSKADTHARKFLTSHNVQLVLSDRIDRDAANQAAALASHETPQTLKTEKGAEITADLVIVALPPKAAGVSGALSESFPGAIDEQGLLKVDQYLRVASAGNNNIFAAGDVTNADDKFAHRATAAGAVVAANILATIKKPAQPSLKTYSRLASPVFAISMGRTYGFGRLPLLGYSHGWLVTSVKSKQMFVNAVPSTFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH62</accession>
    <name>A0A0D2UH62_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_009819</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 25">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 17">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UH62">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UH62"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UH62"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH62"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="2174"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="2224"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="2707"/>
            <end position="3416"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="3590"/>
            <end position="3902"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="3950"/>
            <end position="3982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="180"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="3102"/>
            <end position="3154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="3195"/>
            <end position="3230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="3102"/>
            <end position="3111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="3112"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="3141"/>
            <end position="3154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="3195"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="3212"/>
            <end position="3225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE94456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3982" mass="441534" checksum="7E1609C394DFC605" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHI6</accession>
    <name>A0A0D2UHI6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHI6"/>
    <dbReference type="OrthoDB" id="168404at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1951"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2222"/>
            <end position="2467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2531"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2581"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2722"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2763"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1901"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1930"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1986"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2224"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2253"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2289"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2327"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2347"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2376"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2433"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2447"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2552"/>
            <end position="2561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2728"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2774"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2804"/>
            <end position="2817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2826" mass="298130" checksum="3644A7854254A5BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ82</accession>
    <name>A0A0D2UJ82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ82"/>
    <dbReference type="InParanoid" id="A0A0D2UJ82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="27768" checksum="37A0C2371137C03E" modified="2015-04-29" version="1">MRSKCPVKVDGIARAASAALRVPIRVHKLHACQNMLRSGVVHATQAKSSCLLGDASNRRVGDFDRGKASKRIVIFVEVLAGVGHEFGHVVVCDRADLVGVARVLQGLRPTLEVNVDLQLRHQDFGRAINFAVDGVDERLNRSAGNGVIHWVLDDIFKLDLYVLHGATGGRGNGHVNDATVRVVDLDGHIGRQWDGVSPQIVRAVGRVITVSVCVGANVVDVDSNLASGGDRVSACDDDGFTRSLADGRALGRSVGTRFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJW8</accession>
    <name>A0A0D2UJW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CMGC/MAPK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJW8"/>
    <dbReference type="STRING" id="595528.A0A0D2UJW8"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJW8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="92"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1056" mass="110825" checksum="D9AEF58B52B31AAB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKZ4</accession>
    <name>A0A0D2UKZ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKZ4"/>
    <dbReference type="InParanoid" id="A0A0D2UKZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="17033" checksum="F2108A99DEB0A89C" modified="2015-04-29" version="1">MAPQIVNQKARVTARTLELGSLRVGCFDALEVEAAVRVGAIPRADIHDADFWDACARASLGRHHRGNVVKSMGKVARVRGIRGGAGTGRKQARGAVTWCRRVAATAARAGRGHKTVGARLEQVSARRCPRTPTFGSVMRRLARHVSHRVAALVVERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ49</accession>
    <name>A0A0D2UQ49_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ49"/>
    <dbReference type="FunCoup" id="A0A0D2UQ49">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQ49"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQ49"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQ49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="81"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="228" mass="25597" checksum="6808F36F64882786" modified="2015-04-29" version="1">MLSCSLISKLSSRSVGQRSLALSFCFVPFPTTALLCVFLFHCLSRSFLSRSFLSSFFQMCFSTLPFVPSLDQQPLQAMSTKARRRLMRDFKRLQDDPPAGVSGAPTDNNIMVWNAVIFGPEGTPFEDGTFKLSLEFTENYPNRPPTVKFVSQMFHPNVYADGGICLDILQNRWSPTYDVAAILTSIQSLLDEPNPNSPANSAAAQLYQENKREYEKKVKAIVEASWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ89</accession>
    <name>A0A0D2UQ89_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343490.2">
        <property type="nucleotide sequence ID" value="XM_004343440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ89"/>
    <dbReference type="STRING" id="595528.A0A0D2UQ89"/>
    <dbReference type="eggNOG" id="ENOG502S7ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQ89"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQ89"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="365" mass="39814" checksum="4D3D2136CB6D9C2C" modified="2015-04-29" version="1">MAANAIRRISALLPSLTSSRLSTRMASSTAATMSSSSASSSSSASSSTAPAPSKHDSDATVDVAEIGPHRTWTVTTDDGLATLACESFAPPVDSDPKLPVLLFTHANGFSKTTLHPFMAELRKHGSRHPFLAIDFHGHGESSNHQREDWDWWTLGKDVTTVVDAYRAKDPSRSLVGVGHSIGGAAIFMLEHYRPGTLKSIIAFEPIMFPKEFTSHGGHDDLVKGTLKRRAVFPSFAAAKQQFVKKRMYAALDSRALNEYVFNSMRQLPDGSVTLKCAPAVEAKNFSNGHKHDMFDKLADLKLPVLYVAGEESEFVPLSLAESQHEATPNSQLQVLPNVGHMLPLENPELLAKTVLKRLSEQNLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQJ4</accession>
    <name>A0A0D2UQJ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQJ4"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQJ4"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQJ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51862" checksum="4DDB1A201DB2A576" modified="2015-04-29" version="1">MTERQRELYDKVKNASGNLILGDHQTGDDEAKAIAEALKVNKTVTWLILWATQIGHVGAQAIAEALKVNRTLKELHLHTNQIGDAGAQAIAEALEVNTALRRLDLGCNQIGKAGARAIAEALKANTTLTSLDLWESQIGDAGVQAIFEALKENATVTKLGLSDSQIGDAGAHAIAEALKVNKTLSCLKLCACQIGDAGAHAIAEALRVNKTVTTLYLHENQIGDAGARAIAEALRVNTTLTQLYLHMNQIGDVGAQAIAEALKLNTMVNELFLSGNQIGDIGVHAIAEALKVNTTVTELDLRYNCIGNVGLQAFDEMCQVNRTLSNFWIDGQINPLAFSLLPRLATAEDLHNVFHLLSSGLALEDQPTSLPALPNEIAELIMDEAHYWQGVQQSKRSEFDDEFPAYLILKVTLPQCVNGNSIRIKAIQVLRDWRKRPDNTANDPIIRQMRAGWQVQVRTSKSSRDELFESLYVGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQM2</accession>
    <name>A0A0D2UQM2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nudix hydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343618.2">
        <property type="nucleotide sequence ID" value="XM_004343568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQM2"/>
    <dbReference type="STRING" id="595528.A0A0D2UQM2"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQM2"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQM2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="40062" checksum="00629E518E9EBC7E" modified="2015-04-29" version="1">MLQRAQSVVLATTATAAARAWCTCTVPAMRSTLRAAGPRASVSCKPLEHLQRRFLFTARPGGASTESPSPPTSDGATLAPASTGLSAAAGAASTAASTAAAVAGSALLDHSPQTAAAPPTPPLVVSVPGVQRPVHCEPVAADETRIPTAHLLGAPERARMVAALKSLKRRHLSRQRSAAVLVPLCTVNGVPSVLFTVRASSLSSHSGEVSFPGGIRDPTDASIEETALRESFEELAIPKDQIDILGCFHDTLDKSRTISVTPVIGVLKDGFQLSDMRLSPGEVASAFTLPIDQIINPAVRQFAIMDKQSGYRMPVYQGGPAAVWGLTAFIVECALAMVVVPASVDDTTSPAVRDAVERYRRVTETNMTERAARFVQSLSKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH45</accession>
    <name>A0A0D2VH45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365634.1">
        <property type="nucleotide sequence ID" value="XM_004365577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH45"/>
    <dbReference type="STRING" id="595528.A0A0D2VH45"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH45"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH45"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="722" mass="77399" checksum="DDDA0152F015906C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHK3</accession>
    <name>A0A0D2VHK3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365770.1">
        <property type="nucleotide sequence ID" value="XM_004365713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHK3"/>
    <dbReference type="InParanoid" id="A0A0D2VHK3"/>
    <dbReference type="OMA" id="PEMHSHE"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="675" mass="69704" checksum="F22A5A360FF95D6D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI85</accession>
    <name>A0A0D2VI85_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin IB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365949.1">
        <property type="nucleotide sequence ID" value="XM_004365892.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI85"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI85"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI85"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF679">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="55"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1569"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1579"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1589" mass="177466" checksum="8E6C1F03C030CE6D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJM1</accession>
    <name>A0A0D2VJM1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364386.1">
        <property type="nucleotide sequence ID" value="XM_004364329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJM1"/>
    <dbReference type="InParanoid" id="A0A0D2VJM1"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="475" mass="51618" checksum="19E7C0B9B93D03D6" modified="2015-04-29" version="1">MSSPLELVDYVAQPPLEYPRRIIVNPFKEHLELREHLFQLYGDPVTAEANAAMRSVAVNFSLLLVGGLVFIPFALVFRRWSWKLSTAISIAGAIITMIACIRLSGGSGTIEWVTVLKFAWINMCMCIASIGVSAIRGSLRLAGECCCPNFNLESHRPHDSCLARIARKTAANIWWFSWQLEEALQWTLLCNAVGITLTYMSALTEVCSGRAFGNGASHIVFGLAFVLYGVACIALSLNAVKTRAFEFREACAGLVIGVILVVTQHGWPYHFFETAWNETDISNVGTGAFFVIAGLGGLLFTSRLGRAAMGNSHSPNIFPTIALLSTATVRLFLWSPTTYSSDVYATFAALLSLAGIGRLFMSCKSLRGAHVTGTMLVMAGTVLCGAGDGALRAAEQHQLEVTGYILILAVSGLGVSVYMTCLFVVRWNLLKTRAGCNRHSPALPHHQVATKPGIVYQLLNPRNSSKHQDSVLIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKR0</accession>
    <name>A0A0D2VKR0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270141.1">
        <property type="nucleotide sequence ID" value="XM_011271839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKR0"/>
    <dbReference type="InParanoid" id="A0A0D2VKR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="667" mass="68597" checksum="9B8CA30F94E0DC9F" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL85</accession>
    <name>A0A0D2VL85_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL85"/>
    <dbReference type="STRING" id="595528.A0A0D2VL85"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL85"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="993" mass="107747" checksum="558A875103979B80" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLE7</accession>
    <name>A0A0D2VLE7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348913.2">
        <property type="nucleotide sequence ID" value="XM_004348863.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLE7"/>
    <dbReference type="STRING" id="595528.A0A0D2VLE7"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLE7"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="4">
        <location>
            <begin position="39"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="347" mass="37633" checksum="2C52778F666FFD16" modified="2015-04-29" version="1">MMETSDALPTSSSTATTTTTATSTSAANVIASNVKSSLQIALHPLVILNISDHWTRTRAQHSVANPSVFGALIGTQNGRNFEIFNSFELVVRNEPTGSGAGPEAMQTDNDSSSSSSSAAPTSSEWVVDVEYFRRKQEQFKKVFANYDFLGWYSTSKSVCELGNETPLYLQLNPAGTATAKDVPVSIFESVIDMVNGQPQMLFIPVSYRVESGEAERISVDHVAKSSGGDTPNVSSVSAQLGVQHSAIQMLYQRIDVIRNFLVAVQQGSVEADPALLREIASLCNRLPNLDSPDLAEERLRECTDVMLISYLGSVTKGCQALNSGPRKSLQSYQTGSQRWQRQAALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLZ3</accession>
    <name>A0A0D2VLZ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349040.1">
        <property type="nucleotide sequence ID" value="XM_004348990.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLZ3"/>
    <dbReference type="STRING" id="595528.A0A0D2VLZ3"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLZ3"/>
    <dbReference type="OMA" id="REMTHEP"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="6">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20926" checksum="2368586C9AD713B7" modified="2015-04-29" version="1">MSSWVDYYRILNVAPDNSIEVIRKAYQRLLLRHHPDKAALVNGLQADSSAAAATASPAPGATALEPDTMMMMTGVTRAPADPSTSDTSVFLLIQEAWETLRDAQLRAVYDAQRSNAYLSLVAAVNEDLVLEDWDFDDGEGCYIYPCRCSGEFVATPRNFAGRVELFGCTNCSLAVRMVYPSTESTVEDDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM22</accession>
    <name>A0A0D2VM22_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM22"/>
    <dbReference type="InParanoid" id="A0A0D2VM22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="256" mass="28105" checksum="3B2B2F1605A26304" modified="2015-04-29" version="1">MQTRSQHSAHFTQCLQLKAKHLLEANDLIPTKQKVTTKNNNNKKKIPHRLSAPHSKHHSPLANGTHTSLKRKLGATANSTTEVLGYQLWLVLEVGVNQLVGISPRKHAVPVSWRIDDNDARILVAAEMRAAAHSDRVVANGSLGHQLGQLVHHLGTRASASCVARAVCANQHEIALVHGFVGNVLRNHTANHLVLDKFGNLLNRDSKVPYPFRIDNDIRAKVALCELAARSDERHALAALRRCIGSDVRGGACCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN90</accession>
    <name>A0A0D2VN90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acid phosphatase</fullName>
            <ecNumber evidence="2 5">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 2 iron ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348649.1">
        <property type="nucleotide sequence ID" value="XM_004348599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN90"/>
    <dbReference type="STRING" id="595528.A0A0D2VN90"/>
    <dbReference type="eggNOG" id="KOG2679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN90"/>
    <dbReference type="OMA" id="GFCIHEL"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN90"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253736" description="acid phosphatase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="337" mass="37481" checksum="1551A069D9AF1A1B" modified="2015-04-29" version="1">MTGQRWIWSYMVVIAATWASGASARAVNAAAAQEETPLHFLTLGDWGLNGDQQTEVAQALGNVGGIFHPSFLVSVGDNFYDVGVANVTDPLWKTAFDDIYTHPSLNITWYSLLGNHDHEGNISAQVAYTNVDRNRRWHMPSSWYTQVVVLPDGLTTLQFVFIDTVIMSPDFYFNELEGMVADGRRSRSAVDAQLAKRETMRSDADVQLDWIKTTLSSSKADWLVVAGHYPVYSGGSNGNNPDLQDDLKPLLEKYQVDAYLCGHDHELQVLHHNGVKYLVSGAGAKLGKYNPIKQNRFGASTGGFMLQSFNSTTMTINVYDTQSTVLYQEFVPRVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP38</accession>
    <name>A0A0D2VP38_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364005.1">
        <property type="nucleotide sequence ID" value="XM_004363948.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP38"/>
    <dbReference type="eggNOG" id="ENOG502S2JD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP38"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253762" evidence="3">
        <location>
            <begin position="32"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="602" mass="66498" checksum="2CFC8FFBE99210DC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQS8</accession>
    <name>A0A0D2VQS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363648.1">
        <property type="nucleotide sequence ID" value="XM_004363591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQS8"/>
    <dbReference type="STRING" id="595528.A0A0D2VQS8"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQS8"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="897"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="122190" checksum="B7650158EE1160E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRV1</accession>
    <name>A0A0D2VRV1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_009768</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRV1"/>
    <dbReference type="eggNOG" id="KOG4418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRV1"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269501" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="407"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="753" mass="83242" checksum="53AC4F4DC173F151" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRW0</accession>
    <name>A0A0D2VRW0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRW0"/>
    <dbReference type="eggNOG" id="ENOG502S6YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRW0"/>
    <dbReference type="OrthoDB" id="68104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRW0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="295" mass="31594" checksum="D52FF0FE49FDA1CA" modified="2015-04-29" version="1">MGMALRQASAQPVHGARLGSGGSARSMTTSLKIAQTHVAEEIATHPEAPAPDPVRLTTRDSVQGRLIVEELGIVAGSSARSRNFLVDLWTRLRGFLGGELTSYSEMFTEATNEATEQAMKEAEALGATSIIRVRYQNACTETKITGVSVYVLCYGTAVRCVDRTSDAAHEYLRQLESVPMSFSKQQKEKAPEPGSASADAIAAAKPPATPVPTTIADVAAPTVAPSHIQQQLLSHPALLQQQIDLQHHQIQQLLALQQVQLTQLQSKLEAPTPEKEVILNVASSAKSTIVTAVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTV3</accession>
    <name>A0A0D2VTV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347026.1">
        <property type="nucleotide sequence ID" value="XM_004346976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTV3"/>
    <dbReference type="STRING" id="595528.A0A0D2VTV3"/>
    <dbReference type="eggNOG" id="ENOG502QRYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTV3"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="61351" checksum="567ECBF38948B9E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU03</accession>
    <name>A0A0D2VU03_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270548.1">
        <property type="nucleotide sequence ID" value="XM_011272246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU03"/>
    <dbReference type="InParanoid" id="A0A0D2VU03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="62" mass="6916" checksum="E471026A2E906891" modified="2015-04-29" version="1">MPAENEKTVNMPTTTTVEEKPVEQPNIAERIGNAFVHAKDVMAEKMGLSHKETHKDETQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU25</accession>
    <name>A0A0D2VU25_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270554.1">
        <property type="nucleotide sequence ID" value="XM_011272252.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VU25"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU25"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU25"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="312"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1283" mass="138529" checksum="65E129A364E2E5FC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUQ4</accession>
    <name>A0A0D2VUQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nisch protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346260.2">
        <property type="nucleotide sequence ID" value="XM_004346210.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VUQ4"/>
    <dbReference type="eggNOG" id="KOG1259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUQ4"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031782">
        <property type="entry name" value="LIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057292">
        <property type="entry name" value="PH_S11IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF35">
        <property type="entry name" value="NISCHARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15904">
        <property type="entry name" value="LIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25357">
        <property type="entry name" value="PH_S11IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LKB1 serine/threonine kinase interacting protein 1 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein kinase 11-interacting protein PH" evidence="5">
        <location>
            <begin position="733"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="898"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1510" mass="162068" checksum="19E8B0C49C9651B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVX1</accession>
    <name>A0A0D2VVX1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270610.1">
        <property type="nucleotide sequence ID" value="XM_011272308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVX1"/>
    <dbReference type="FunCoup" id="A0A0D2VVX1">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VVX1"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVX1"/>
    <dbReference type="OMA" id="LFITWNK"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="214" mass="24275" checksum="B6F76960000FD78E" modified="2015-04-29" version="1">MSATTTTALSADLCRYCFDTLSNHFSSRHPVAPPSFGNESYPLFVTWNMLNKGHSHPTSSEDAHSEHSYALRGCIGTFSARPLHDGLAEFSLRSALKDRRFSPISEKELPHLTCGVSLLINFEDAADYLDWEIGVHGIWIEFVTEGGYKETATYLPEVMPEQGWTKIEAIDSLLRKGGYRAKITEEVRSNIKLTRYQSVKFRMTHPEYLRLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX30</accession>
    <name>A0A0D2VX30_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345261.2">
        <property type="nucleotide sequence ID" value="XM_004345211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX30"/>
    <dbReference type="FunCoup" id="A0A0D2VX30">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX30"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX30"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="433"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="791"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1105" mass="115269" checksum="F9B07A0B5401BF5E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXA9</accession>
    <name>A0A0D2VXA9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344235.2">
        <property type="nucleotide sequence ID" value="XM_004344185.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXA9"/>
    <dbReference type="STRING" id="595528.A0A0D2VXA9"/>
    <dbReference type="InParanoid" id="A0A0D2VXA9"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051012">
        <property type="entry name" value="CellSynth/LPSAsmb/PSIAsmb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586:SF1">
        <property type="entry name" value="LIPOPOLYSACCHARIDE ASSEMBLY PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN PA4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253942" evidence="5">
        <location>
            <begin position="28"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="643" mass="72069" checksum="65179CA120FC17D5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXZ3</accession>
    <name>A0A0D2VXZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome c-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_006849</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="14">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344470.1">
        <property type="nucleotide sequence ID" value="XM_004344420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXZ3"/>
    <dbReference type="FunCoup" id="A0A0D2VXZ3">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VXZ3"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXZ3"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VXZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="16">
        <location>
            <begin position="57"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="273" mass="29810" checksum="C30EAE9C5E787442" modified="2015-04-29" version="1">MFARLFRGRAGLLTAAAGASTVAAAGFYTTVLASSDELHPAAYPWSHGGPLSSFDHASVRRGFEVYKQVCSACHSLDKIAFRNLVGVTHTLDEAKALAADVDVEDGPDDSGKMFKRPGKLSDYMPRPYPNDQAARFANGGALPPDLSLVIKARHGREDYLFALLTGYKEPPAGIVLREGLHYNPYFAGGAIGMAQALYDEMIEYEDGTPASQSQMAKDVATFLAWAAEPEMNERKRMGMKAITLLTLAAGATWYVKRQRWSVLKTRKHVYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0J0</accession>
    <name>A0A0D2W0J0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0J0"/>
    <dbReference type="FunCoup" id="A0A0D2W0J0">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0J0"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0J0"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0J0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="389"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="454" mass="50381" checksum="C145145D760804EB" modified="2015-04-29" version="1">MTSQKRPREDDLDDDNERRVRFAADQAEHEQDDAAPPDHTAAHGRLHRLSHATEDEADDGRARYQHRGLRAGQIDNPDERDRGDGDDDDDDGEEDGDDEQAMKRYYLQEAHLLGQRESMAEGVSIGGTGVRFTPFNLDDEMAEGDYDEQGNYSVKKRDKDEENDAWADSVDWQGLAAKEQARKSKKGNQRNNKSEDDRNPVGDVLMNDDNDERDPLQVAAAKRQRKEAQKSKESSDEESAAESEDDEDAAARPSATQLLERLLQFLEPGETVAAALRRLGGKNSATAKKKHYSDKAKQAAVSQEAKASAAEQKGRMLELIETAHQLVASGYTNVYDDTIDTIQHQLQHGHAPDFGQSADGSEESKDAGQPAQEAVANPPAQAPPTLSDEVHWEYKMQNTPDADVHGPFANSQMMEWKDAGYFDSQPVFVRKYVAGGDNSAAYNSVARVDFDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0U4</accession>
    <name>A0A0D2W0U4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase DDX24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0U4"/>
    <dbReference type="FunCoup" id="A0A0D2W0U4">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0U4"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0U4"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0U4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="464"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="846"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1039" mass="112820" checksum="DC3212E0754C53CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W209</accession>
    <name>A0A0D2W209_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346412">
        <property type="protein sequence ID" value="KJE98392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W209"/>
    <dbReference type="InParanoid" id="A0A0D2W209"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W209"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="674" mass="75309" checksum="955DD4B74BA4A645" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGQ2</accession>
    <name>A0A0D2WGQ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic arrest defective protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGQ2"/>
    <dbReference type="FunCoup" id="A0A0D2WGQ2">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGQ2"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGQ2"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGQ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="154"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="373" mass="40850" checksum="64FB569B51EBE47F" modified="2015-04-29" version="1">MRSSRDSRAAAAPPNQSWTSMHNDNNAMMLDDKDHNDNDNDDDDVDDDDLLQARMRDQPSTSAAAAAAARPPMMKPPLSSLIGNHASTTSGAGLITSGSAAQVAGARNLVNAAPAALPSHPNTTSHSNAQQPVGSNPAPALPAEQSDQVGLDYNASVDILCDFLEVAIHMILYARQLYPMESFERRKKFNVPVYMNRHPELNRYILDIVSSLRPWMEKRLVTRVAVNVVNPVDTSTDETAILERFVFEVQAATLPASRSVSLADIELMLRAVLIKISLCDALLQPVLAKDLETRSFSVCVFTRPEASGTIGMYKDHRLPWIMAEPRDAILANPFLHPLKSVHTGLLQMQLFVEERAVEEQHVGLDPGQAAMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGQ9</accession>
    <name>A0A0D2WGQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365113.1">
        <property type="nucleotide sequence ID" value="XM_004365056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGQ9"/>
    <dbReference type="FunCoup" id="A0A0D2WGQ9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGQ9"/>
    <dbReference type="eggNOG" id="ENOG502SDTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGQ9"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="66" mass="7154" checksum="16104FF57651B720" modified="2015-04-29" version="1">MVTLNAPKRSSSCAGDYLTTCQSAIFNFQSLLLVVLLVICTCTYIHDFAPALLDRHKTGQHALANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHZ8</accession>
    <name>A0A0D2WHZ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365725.1">
        <property type="nucleotide sequence ID" value="XM_004365668.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHZ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WHZ8"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHZ8"/>
    <dbReference type="OMA" id="ANGHCEG"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="511" mass="55437" checksum="8A7D0096AF7653FB" modified="2015-04-29" version="1">MFHQLTPLLEHKLESLTPVTVVSETASTPATATPATVAPATKLVPAFEVTDDESGDASCPAPVTYLDLSRKKLKTLPASVLEHRSTLQVLNLSHNQLSELPPELFELTELRSLNISNNPIASLPDTFERLPQLRTLTCNNMALTTVTDNLVRCRQLVSVYFGGNQLKEFPLVLCFITTLKYLYIGANQIHSLPAEISQLSELEVLYLGGNKLERLPAQIGLLKKLNVLFLGDNSLVELPVEITDLDSLMTLNVHSNKLSALPMGLLQLPRLEELSLRNNPLVTDFVRTIPLTPPSLKELAGRVIKNQEIPYSKETLPLDLVELLNTGRVCENPNCRGVYFSDRCESVQFVDFCGKYRVPFMQYLCSPRHADSDYSAKRRADEALASEQAARNATAMRMQALRDELEAGRLATEVNLDLSLQDLGASLSSSSSSSSALSSSSSSSASSSSASSSSAAAAAAPTDVRLSAASSSSSSPSASEPSTSSPAPLRELNSLELRLLKLVENEAWIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI16</accession>
    <name>A0A0D2WI16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI16"/>
    <dbReference type="STRING" id="595528.A0A0D2WI16"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI16"/>
    <dbReference type="OrthoDB" id="72369at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254391" description="Disease resistance R13L4/SHOC-2-like LRR domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="6">
        <location>
            <begin position="225"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="746" mass="78423" checksum="908CFC84349B6592" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIE6</accession>
    <name>A0A0D2WIE6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIE6"/>
    <dbReference type="FunCoup" id="A0A0D2WIE6">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIE6"/>
    <dbReference type="InParanoid" id="A0A0D2WIE6"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="151"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="36168" checksum="AEA16F3A3002A7C3" modified="2015-04-29" version="1">MSGNEARPASGTGHAFEFHDGAPVLTTRRLLKATHGTALWPHLSGSSDITGTLNTRTGRAGADDNDSLNGDGSFGFSDNVTLLREENAAQRNYGAPIWSLEYYAQFFNIETHVVRRRLVTALWPFGARMLDTLNSNPDLYGTEPSRHFDEGPIWISTTLVFAMAMAGNFSSYLASETAWQYDFEMVTFGATSVYGYVLVVPLLLWAALRWLIGNGRIAFTELVCLYGYSLSIFIPVALLSIFQVEWFRWLAVIIALFFSGGALLTNIWPLLRTHPHRISYGICAAMLLSHATLAIVFKLFFFEYNAAVGSSGNTPAPAPSHTPVPSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIY8</accession>
    <name>A0A0D2WIY8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Stromal membrane-associated GTPase-activating protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365526.2">
        <property type="nucleotide sequence ID" value="XM_004365469.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIY8"/>
    <dbReference type="eggNOG" id="KOG1117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIY8"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIY8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="644"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="762"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="885"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="1346"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="11">
        <location>
            <begin position="1673"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1757"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1550"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1858" mass="200106" checksum="07D7C78E55F4B1BA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ37</accession>
    <name>A0A0D2WJ37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(Ser) (uridine(44)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000742</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365613.2">
        <property type="nucleotide sequence ID" value="XM_004365556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ37"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ37"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ37"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="800"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="800"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="837" mass="91417" checksum="B137F834D6E8E2A9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJE6</accession>
    <name>A0A0D2WJE6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WAS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364356.1">
        <property type="nucleotide sequence ID" value="XM_004364299.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJE6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJE6"/>
    <dbReference type="eggNOG" id="ENOG502QSX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJE6"/>
    <dbReference type="OMA" id="SMDSPYE"/>
    <dbReference type="OrthoDB" id="307871at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="477" mass="50185" checksum="F0F4EDE6A7B48138" modified="2015-04-29" version="1">MVANSSYTVSVTQPFLRQEESVKQLVNSLQYVEQVAHDVFNRITTRVAQNREQLVTLNNRVNVALAKISKIRGSTKATTVFSSAKYPAPETLDDYRPLFGDGQTAPVPNPPKLRPHEIRTKHSHMADAEWKDRVNYFAIDINVAREPEIITDEDEGEGLGRLPKHLPSVSSLLLFNTAENPYKKYVTLDPLSGVQHKTRTLDEDGGIKIDAAPQSILSGDQMLRGTAENYFYSPGMGAVPEIQVPGNLPDLPGVADDIAWEADLGPSIAPSMPGSNMPELPTVAGVAAPRAQQPGTVSTSVSSTPSSVSAPPPPSAAPPPPPPPSAAPPPPPPPPADMGPPPPAPANVPLEVAEPDSGRGGLLDAIRAAGGAGKAKLKSVKDRKLEAKKAKKEAAAAGDGEEEDGGNSGGGGGGGDMMGDLIATLNRRRKGISGSSKPSNNERSEESSGNPMDKISAMIPAPKARAESQASDHDAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJV8</accession>
    <name>A0A0D2WJV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270054.1">
        <property type="nucleotide sequence ID" value="XM_011271752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJV8"/>
    <dbReference type="InParanoid" id="A0A0D2WJV8"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="139" mass="15518" checksum="83CFE99FED5DA7B8" modified="2015-04-29" version="1">MSNQHQQISSESYLFALREYQQASLEFISRLSAENHALKCEIDTLKKDNTQLTARIGGLEALCREKDAAFATLQQRAEAHAPVKLEIPKRIRFKMTETAPRTPEYNMALGRPLNPVLFKATSGAKEANAATGQAITRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJZ3</accession>
    <name>A0A0D2WJZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJZ3"/>
    <dbReference type="InParanoid" id="A0A0D2WJZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="119" mass="14208" checksum="AB5BDF92B3A4E40A" modified="2015-04-29" version="1">MRVQAAWVACCCRLRSDHLLWAAALAADRHRRRFPSAVVHLLRRPGSPGLARHHHCGRAHHRAALGPGWHWHWHWHWRRPRPVAVEIGDCAYHWPNLGWQRRRRRWSPHRTRVGMHAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLM6</accession>
    <name>A0A0D2WLM6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLM6"/>
    <dbReference type="STRING" id="595528.A0A0D2WLM6"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLM6"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="484" mass="51474" checksum="3912CBDAE3F4BCCE" modified="2015-04-29" version="1">MSFLLNLLPPRALFGGIFNLTNSIMGVSLLAMPLCFYQCGLAFGMFLSLLATFLSLISCKLMLHSSRVSGSKWGKLAVEVCIIGLLLGSCVAFFAIVADILPRFASVWFFPDQSAVALRTPVMSILAVAVVFPLSLMRNVSSLSPLNAISLGFYGCFIVALIYSIASPSEAEQAPEGAPSSELKWFDPSGFLLTLPIFSLAYTCQFGVFAVYAGLPNPNHKAMNTVINYSIFLASFLYSAVGVFGYIAFSHVDIDGDLLNNFPDGVVFFDILKLGFSISIIFSFPITVYPCRAALNTLIFVPNAPASTTPDVLQSAAAPEPVIPGARFFGLTAGIVFSALIVALAIPEVATILSFTGSTTGTSLAYILPASTFLVLVRAADVKPRLRRIAILILVLGVVCCIGSTALVLYSTNPLPVKEVTNSVDIPIEGDTGVKERDVSSSLNRSISSLSLQSFSRLPSVVSLPISSSAEAGLPPKKSLVNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLV6</accession>
    <name>A0A0D2WLV6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349493.1">
        <property type="nucleotide sequence ID" value="XM_004349443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLV6"/>
    <dbReference type="InParanoid" id="A0A0D2WLV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="719" mass="75594" checksum="0FFE21819D38CEF3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WME3</accession>
    <name>A0A0D2WME3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349216.1">
        <property type="nucleotide sequence ID" value="XM_004349166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WME3"/>
    <dbReference type="FunCoup" id="A0A0D2WME3">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WME3"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WME3"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WME3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="66"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="389" mass="42285" checksum="8971401E02CD521A" modified="2015-04-29" version="1">MFALTSASSRALTAAATRAFATSAAAPSSAAGVRFDFPVPFMTHKCSGLPDHAMATKEELLDYYRTMQVIRRMETAAGDLYKSKFIRGFCHLYSGQEAVCTGVEAAITKEDSVITAYRAHGFTYVRGVSVKGVLAELTGRQGGCAKGKGGSMHMYNHNFFGGNGIVGAQVPLGAGIALAHQYQGNKKVCISLYGDGAANQGQIFEAYNMAALWKLPAIFICENNQYGMGTAIGRAAASTEYYTRGDYIPGIKVNGMDVLAVREATKFAVDHARAGKGPFVLEMITYRYGGHSMSDPGTSYRSREEIQQMRSNNDPINNVKNRLLSTNLATAEELKEIDQAVRKEVDEAVEFAKEDAELPVEEAYTDVYKDTVPEAIRGCDPFTWAHPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMS7</accession>
    <name>A0A0D2WMS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364083.2">
        <property type="nucleotide sequence ID" value="XM_004364026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMS7"/>
    <dbReference type="FunCoup" id="A0A0D2WMS7">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMS7"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMS7"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="433" mass="47492" checksum="BB0FADC9476B2820" modified="2015-04-29" version="1">MMTLPRLQQHMRSGYSTAHSLVRASHRDFASTSSPQRAAAASEHATPASFIVANAQPRIVSGIQPTGGVPHLGNYLGAIKSWVQLQDPAIQAQRMRGSTSDGQRSEPSGSASHSVSAVSSQPSNPSNSAVDVLYMIVDLHALTVAPEKAVLRRNITDMTIALLACGINPAKSVLFQQSKVSGHSELMWLLGCITSNSWLSRMTQWKAKKQQLLASKSLDKHDWGLYSYPILMAADVLLYRGTHVPVGDDQQQHLELASTLANTFNHVHKSAFFPAPVPMYNDAKRIMNLRNPVNKMSKSDVSDASRINLTDSDDDIRSKLRRALTDTNENSITFDPENRPGVANLLSIAAAIRGETPQSMAEHYTKSNLNMRGLKDAVMELVIAEVKPIREKIAELQADEKAVHRILEEGSHRANEMSRGTLQEVRKLVGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN57</accession>
    <name>A0A0D2WN57_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363693.2">
        <property type="nucleotide sequence ID" value="XM_004363636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN57"/>
    <dbReference type="InParanoid" id="A0A0D2WN57"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="449" mass="47418" checksum="E188EE0BD38E6791" modified="2015-04-29" version="1">MASSSSLQTLVVRTAPLPGFVPSTAAPLPSSSLSSSSSSSMAGQSLTAAAAAAAGDVVVEIAASASLRDVKQRIAQTHPLRPPVDAQRLVYAGRVWTDSATVRDMLQSPLALHLKAQHSQPMLVVHLILPASIANQHHHNHHNQHHHQQQKPTPTPQSSTNPANLPLPLRADTSTDTTIQAQAPPHDATTPSRNTLHDAIAAAHLPNAHAAMYSHALLIQQQQQNLMLQHQLQQMQAIYMQTMMPPFASPFVMSPLHAAPPPALVDPALFPQPFMQAPHYPFNPVEEPLVAPEPIDPAVAEAMAEEEQIVRDAEIAAALEDEMEPREGPLSLLIKLVIVGYILTQNASFYKKAAVLIIAILIFIVQSGLLRRRPQPQRRQQPPHPPAQAAPVAAGGGGAGSAAANVPAGDTPDAANAVPAAPVMPQSTTSFTAPLGGASPISVCLFAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN75</accession>
    <name>A0A0D2WN75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome beta 4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN75"/>
    <dbReference type="FunCoup" id="A0A0D2WN75">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WN75"/>
    <dbReference type="MEROPS" id="T01.A13"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN75"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="290" mass="31593" checksum="7CCC22D9E514F394" modified="2015-04-29" version="1">MCVCFGTLTLQVSFSRPFPVNTMSGTGLSFERNTFMPAMAMNLNRPSSASAAASNAMRPLSAPATDGPTRHTSNPIVTGTSVLAIKYAGGVVVAADTCGSYGSLAKFRNISRMNTVGSKTLLAMSGDYADYQYVKKTLDDLVIEDECVNDGHQLSSSSIFSYLSRVMYNRRSKIDPLWNTFVVAGSSNGQPFLGTVDKVGVAYTENHIATGYGAYMALPLMRDAYAANPNMTLEQAQTVINECLKVMYYRDARSWNQYEMAVITNDGVSISQPYTLPTDWSIATMFQGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNC2</accession>
    <name>A0A0D2WNC2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase 10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363779.1">
        <property type="nucleotide sequence ID" value="XM_004363722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNC2"/>
    <dbReference type="STRING" id="595528.A0A0D2WNC2"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNC2"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="705" mass="77892" checksum="1C7040CD72762FB4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPB9</accession>
    <name>A0A0D2WPB9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347818.1">
        <property type="nucleotide sequence ID" value="XM_004347768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPB9"/>
    <dbReference type="STRING" id="595528.A0A0D2WPB9"/>
    <dbReference type="eggNOG" id="ENOG502QQT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPB9"/>
    <dbReference type="OMA" id="SVFKWEY"/>
    <dbReference type="OrthoDB" id="2193793at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPB9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="397"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="555" mass="61461" checksum="89DD07A281C32E9E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPF9</accession>
    <name>A0A0D2WPF9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peregrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008705</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPF9"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPF9"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="391"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="1152"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="770"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="886"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1382" mass="153195" checksum="190CA2B14C673212" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPN1</accession>
    <name>A0A0D2WPN1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363288.1">
        <property type="nucleotide sequence ID" value="XM_004363231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPN1"/>
    <dbReference type="FunCoup" id="A0A0D2WPN1">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPN1"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPN1"/>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPN1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="334" mass="36140" checksum="CF490A98072E38BE" modified="2015-04-29" version="1">MSAASAASASAASSSPRVLVIQSHVVSGYVGNKSSTFPLQVLGFDVDAINSVQFSNHTGYLSFAGQRLNGDQLWEVFEGLDRSGLLGQYTHLVTGYIGSASFLTTVIRVVRRLKEVNPKLIYVCDPVLGDNGKLYVPEELIPIYQSDVISLADVLSLNQYEAGLVTSSPTPATKQDALAALQTLHNRGIQTIVLHSTDLVATGHANDVVVIGSQRREDGTLDQFELYAPKLPMTFVGTGDLFTALLLAHTHALPAHLDQACEKVIATMQGVLRKTLEHFLTLLPAELKTADNLPVPEAQTSRAHSFHREMRLIQSKSIIECPTVVHKAQPLTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQN1</accession>
    <name>A0A0D2WQN1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HAUS augmin-like complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQN1"/>
    <dbReference type="STRING" id="595528.A0A0D2WQN1"/>
    <dbReference type="eggNOG" id="ENOG502R4I5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQN1"/>
    <dbReference type="OrthoDB" id="2159690at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQN1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026206">
        <property type="entry name" value="HAUS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032733">
        <property type="entry name" value="HAUS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378">
        <property type="entry name" value="GOLGIN- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378:SF0">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14932">
        <property type="entry name" value="HAUS-augmin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 3 N-terminal" evidence="12">
        <location>
            <begin position="54"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="643" mass="71300" checksum="F66198FDE3B1647C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR68</accession>
    <name>A0A0D2WR68_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR68"/>
    <dbReference type="FunCoup" id="A0A0D2WR68">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR68"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR68"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR68"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="86"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="353" mass="38746" checksum="E7CF196D520D8D5F" modified="2015-04-29" version="1">MSLTPAPTAATTLTLPAAADLHVHLRQGDLMRMVVPHIRRGGVVRVLVMPNLKPAIASTEQALAYKRELEQIDASVDYWMTLYLGPEITPDEIRKAAAAGIKGVKSYPRGVTTNSESGIESYTAYYPVFKAMEETNMVLNLHGEVPSNPKDDICVMNAEVHFLKHLEQLHRDFPKLRIVLEHVTTGAAVRKVLELGDTVAATVTVHHLSLIVDDWAGKNHNYCKPVAKYPSDRRALWDAILSGSPKFFLGSDSAPHPRSTKECASGCAGVYTQPHVLPYLASVFEQYNALDKLQAFTSDNGNRFYQAKPSTDTVTLVREPLTVESELSYGDASAAQPAVVPFQAGETLPWRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRW2</accession>
    <name>A0A0D2WRW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydropyrimidinase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347047.1">
        <property type="nucleotide sequence ID" value="XM_004346997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRW2"/>
    <dbReference type="eggNOG" id="ENOG502RKJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRW2"/>
    <dbReference type="OMA" id="FIPTHIN"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010229">
        <property type="entry name" value="Pept_M38_dipep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01975">
        <property type="entry name" value="isoAsp_dipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001238">
        <property type="entry name" value="IadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="74"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="42533" checksum="F9B113E102193BB8" modified="2015-04-29" version="1">MAQADQRPAQSPLTLYVGAEAVYAPEPLGAVDVLVAGDRIAAILERGSQATATATALVQQLGSSGSLVDISGGILVPGLVDVHVHIAGGGGEMGPESRTPEAALSEIVCNGVTTLVGLTGTDSVTRSLENLLAKGRALQRGGLNVALFTGAYRTPPPTLTSSIMQDIITIEQIIGVGEIAISDHRSSVPSFDELTSIVSDARVAGMLAGKTGLSHFHVGQGAEMLEPLWKIVRSTAIPIQNIYPTHVSSRGPGLLADAKKWVEAGGHVDMTADAASATATPTLDALCEFKESGCTMSRITVSSDGYGSFPMFDAKGSLVKYGVGKQDALLATVRRLVKERGWSLEAALPLITSHPGDYVFAGARGRLCKSGAADFIVLNPELSEVRYVVARGVLLKTPTWVSKGMFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRY4</accession>
    <name>A0A0D2WRY4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347531.1">
        <property type="nucleotide sequence ID" value="XM_004347481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRY4"/>
    <dbReference type="eggNOG" id="ENOG502STTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRY4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="643" mass="69631" checksum="6C1404019A58F942" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS16</accession>
    <name>A0A0D2WS16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PI-PLC Y-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347566.1">
        <property type="nucleotide sequence ID" value="XM_004347516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS16"/>
    <dbReference type="eggNOG" id="ENOG502STD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS16"/>
    <dbReference type="OMA" id="ITVCEIN"/>
    <dbReference type="OrthoDB" id="10662142at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="1">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="57318" checksum="78BA0D0AE544F037" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS73</accession>
    <name>A0A0D2WS73_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347657.2">
        <property type="nucleotide sequence ID" value="XM_004347607.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WS73">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WS73"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS73"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="495"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="908"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1280"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1560" mass="168625" checksum="398DE8772D1DC71B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSM0</accession>
    <name>A0A0D2WSM0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346363.1">
        <property type="nucleotide sequence ID" value="XM_004346313.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSM0"/>
    <dbReference type="STRING" id="595528.A0A0D2WSM0"/>
    <dbReference type="eggNOG" id="KOG3599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSM0"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="544" mass="61273" checksum="C9F2DFC5F153B43A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTF4</accession>
    <name>A0A0D2WTF4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345742.1">
        <property type="nucleotide sequence ID" value="XM_004345692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTF4"/>
    <dbReference type="STRING" id="595528.A0A0D2WTF4"/>
    <dbReference type="InParanoid" id="A0A0D2WTF4"/>
    <dbReference type="OMA" id="NIAKHET"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTF4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="340"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="795" mass="88567" checksum="B7482BD556B59CAB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU29</accession>
    <name>A0A0D2WU29_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase HACE1</fullName>
            <ecNumber evidence="5">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">HECT-type E3 ubiquitin transferase HACE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_005774</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Golgi apparatus</location>
            <location evidence="15">Golgi stack membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="5"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346447.2">
        <property type="nucleotide sequence ID" value="XM_004346397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU29"/>
    <dbReference type="STRING" id="595528.A0A0D2WU29"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU29"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF363">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="22">
        <location>
            <begin position="778"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="355"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="580"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE95313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120196" checksum="BCE72585819F5AA3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU40</accession>
    <name>A0A0D2WU40_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346467.1">
        <property type="nucleotide sequence ID" value="XM_004346417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU40"/>
    <dbReference type="InParanoid" id="A0A0D2WU40"/>
    <dbReference type="OMA" id="CAMCCAC"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13770" checksum="DE3449C6313DC9EF" modified="2015-04-29" version="1">MSQPPAYSQYPQQGYPSYPQQGGGYPQQGYPSYPQQAQQGYPPQQGYPPHQNSYGGQPQPGYGYGYQQPGYPTTTNSTTYVVQQPQPQQQVVYVTDNGAAQRQREEDCCLMSMCALLCCCCAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU88</accession>
    <name>A0A0D2WU88_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stretch responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU88"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU88"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU88"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="473"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1277"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1526" mass="167901" checksum="1B2898F747A0837B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUJ0</accession>
    <name>A0A0D2WUJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_006708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344329.1">
        <property type="nucleotide sequence ID" value="XM_004344279.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUJ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WUJ0"/>
    <dbReference type="eggNOG" id="KOG4278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUJ0"/>
    <dbReference type="OMA" id="TLMYMAS"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="261"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE96370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="608" mass="66530" checksum="D15E8F4B4008FE27" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVJ9</accession>
    <name>A0A0D2WVJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily subfamily IIA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344218.1">
        <property type="nucleotide sequence ID" value="XM_004344168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVJ9"/>
    <dbReference type="STRING" id="595528.A0A0D2WVJ9"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVJ9"/>
    <dbReference type="OMA" id="RDWASDQ"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="400" mass="43107" checksum="ADEACEAF34529E15" modified="2015-04-29" version="1">MSFGIAFDIDGVLFQAGAGAYVPLPGARDVLLALNEPAPPHRITVPHVYLTNGTGTTEAGKAEQLRKTLNLPFELPPHQVVLASSPLCELPAIWAASRRPDGTAATATSSIPSAGSEHDEDKKKKKQPRVLVLSHSHDNAVMLARSSGFTNIATVQEFLQKYPFLVPVKGKAPGATSATLTTDELAARQKALELEEPFHSVLLYQSPEDWESALQICTDVLRSRDGRIAGRHNDLLPNEPQFVELHSGNPDFDYGALHATPRITLGAFRRCLEMVFLESTGRTLVSSLYGKPYPSVYDYARRLLEAQAADIAQRSASEGGATPAGASSGDARIARVYAVGDNPLSDIKGANTAGWHSILVRTGCFTGPGNHDEHPATHVCHGVKEALDWILSQERAQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW00</accession>
    <name>A0A0D2WW00_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-conjugating enzyme E2 C</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="12">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">(E3-independent) E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin carrier protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-protein ligase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_006859</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.24" evidence="12"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344480.1">
        <property type="nucleotide sequence ID" value="XM_004344430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW00"/>
    <dbReference type="FunCoup" id="A0A0D2WW00">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW00"/>
    <dbReference type="eggNOG" id="KOG0421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW00"/>
    <dbReference type="OMA" id="PKDNHAV"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000039">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="19">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE96553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="19667" checksum="580C71360A088222" modified="2015-04-29" version="1">MASQNTAPRRTASATATNPKLKSTASTMDGHAVTRRLQQELMQLMGAADLGISAFPQGDSLFSWIGTIKGVSGTVYEGLSYKLLLKFPSAYPFNAPTVTFETPCFHPNVDERGNICLDILKDKWSALYDVRTILLSIQSLLGEPNNESPLNGQAAGLWANQEEFKKLLLQKYNENANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW20</accession>
    <name>A0A0D2WW20_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW20"/>
    <dbReference type="InParanoid" id="A0A0D2WW20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="185" mass="20707" checksum="E311D2F6145E097E" modified="2015-04-29" version="1">MPPISIPTLSLSPPSTLLNHNTATTQSQYSNDSNTHTHGRFLDSWHSSPRRRRPTRRRGKNECITANCSVLFYWLVIRVNGENARTLAGRDQQSGLLSVLLCCVALGCQVPQSSRVESLLRAGLFCIVCLLQIFFFFQIYSSFPIKLSLLLFSLRFPIRSHSCNTHTRALALLFSLSSCCAVRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWR9</accession>
    <name>A0A0D2WWR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343179.1">
        <property type="nucleotide sequence ID" value="XM_004343129.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWR9"/>
    <dbReference type="FunCoup" id="A0A0D2WWR9">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWR9"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWR9"/>
    <dbReference type="OMA" id="ANFGNTC"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWR9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="451" mass="49909" checksum="D3FA9CFB9622D85A" modified="2015-04-29" version="1">MGNSASRVEKTLGQAVPEHERYFGLENFGNTCYCNSVLQALYFCQPFRDGIRERIQSHLAATGGGLTPTPTTSTAMMTTGPIGLATNSPTTTSQAAVAPVPQEETLMSCLCDLFGSIAAQKRRTGVMAPRKFVARLRKENELFRGYMHQDAHEFFNYLVNTLVELLQREIKDARQLQQASRKSSAASGSAAAAAAPTSSSAPTAKEIKTWVHDIFEGTLTNETKCLTCESVSSKDESFLDLSIDIEQHSSITSCLRNFSATETLQSDQKYFCEQCCALQEAQKRMRVKKLPKVLALHLKRFKYIEELQRYRKLHHRVAFPLELRLFETSDEDSAFYDLVSIVVHVGSGPNRGHYIAIVKSHGYWLSFDDDYVDLVEESNLQLYFGSTLDRNDQQSSECGYILFYEARSVDKNSGAAPTAEAAAQATVSAPPSASKQSAPFPSEPQQEGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX77</accession>
    <name>A0A0D2WX77_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343088.1">
        <property type="nucleotide sequence ID" value="XM_004343038.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SF4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX77"/>
    <dbReference type="OMA" id="SPHECCH"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1511" mass="161442" checksum="7369E353639708DE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYH1</accession>
    <name>A0A0D2WYH1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GDP dissociation inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342648.1">
        <property type="nucleotide sequence ID" value="XM_004342599.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYH1"/>
    <dbReference type="FunCoup" id="A0A0D2WYH1">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYH1"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYH1"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYH1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="186" mass="20520" checksum="D7B55A7949070631" modified="2015-04-29" version="1">MADEDIEVEETPGYKAPKAVDLDTLKNLDANDESLKKWKESLLKGSGGASATGKPVVVQKLSLVVADRSDVALDLTGDLNKLKDAPFTIKEGCEYRIKIGFTVNKLVAGLRYVQAVYRKGIKVDNSSVMVGSYGPNAEPYVYTSQVEEAPSGMLARGHYTVKSKFIDDDKVSHLDWQWSFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYU3</accession>
    <name>A0A0D2WYU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270905.1">
        <property type="nucleotide sequence ID" value="XM_011272603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYU3"/>
    <dbReference type="STRING" id="595528.A0A0D2WYU3"/>
    <dbReference type="InParanoid" id="A0A0D2WYU3"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="56309" checksum="9256B5EBEDCE5552" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0A9</accession>
    <name>A0A0D2X0A9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small inducible cytokine subfamily E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365203.1">
        <property type="nucleotide sequence ID" value="XM_004365146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0A9"/>
    <dbReference type="STRING" id="595528.A0A0D2X0A9"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0A9"/>
    <dbReference type="OMA" id="TLCNVQI"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0A9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="154"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="316" mass="32830" checksum="41685877B14CAF6B" modified="2015-04-29" version="1">MASVIARNAILADEAILALSTQLRVLETAARERGLLADSSDPKIQQLQSENAALRKAVADAKQTLIDLERSHGRTVVDAPSASAAAASTSAQPISQAAKGKAAKAAAAATPAAAAAPAADKKAEAAPAAKDKGKKAESSAPASTDAPAAGEDAKVHQLDFRVGRIVSAKKHPDADSLYVEEVDLNEGGKLRTVVSGLVKFVPIEQMQNRLAVLLCNLKPAKMRGVLSEAMVMCASTPDKVEILDPPAGAVPGDRIVFAGHEGKPDEQLNPKKKTWETLAPMFKTNDQRVATFNGVPFSVDGKGVVSAPTLANVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0J5</accession>
    <name>A0A0D2X0J5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365566.1">
        <property type="nucleotide sequence ID" value="XM_004365509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0J5"/>
    <dbReference type="FunCoup" id="A0A0D2X0J5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0J5"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0J5"/>
    <dbReference type="OMA" id="FNQDMQM"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0J5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="17377" checksum="4D62B4676DD37ED0" modified="2015-04-29" version="1">MALPRVFFDITIGGAAAGRVIFELRSDVVPKTAENFRALCTGEKGFGFKNSGFHRIIPDFMCQGGDFTAGNGTGGKSIYGNKFADENFTLKHTGPGILSMANAGPNTNGSQFFICTSKTTWLDGKHVVFGSVVEGLDIVRKMEAQGSQSGTTKAKVVIADCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X103</accession>
    <name>A0A0D2X103_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349873.2">
        <property type="nucleotide sequence ID" value="XM_004349823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X103"/>
    <dbReference type="InParanoid" id="A0A0D2X103"/>
    <dbReference type="PhylomeDB" id="A0A0D2X103"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="751" mass="83153" checksum="74F3B4282DA4138A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1I8</accession>
    <name>A0A0D2X1I8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348872.1">
        <property type="nucleotide sequence ID" value="XM_004348822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1I8"/>
    <dbReference type="InParanoid" id="A0A0D2X1I8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254959" description="FZ domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="78292" checksum="07847C8F475DE5D0" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1J8</accession>
    <name>A0A0D2X1J8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1J8"/>
    <dbReference type="FunCoup" id="A0A0D2X1J8">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1J8"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1J8"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1J8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="738"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="856" mass="93682" checksum="AEBF9F50C2499F7C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X298</accession>
    <name>A0A0D2X298_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCDC43 PWI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364037.1">
        <property type="nucleotide sequence ID" value="XM_004363980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X298"/>
    <dbReference type="eggNOG" id="ENOG502RYDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X298"/>
    <dbReference type="OMA" id="KFLFRNT"/>
    <dbReference type="OrthoDB" id="2187466at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X298"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="217" mass="24999" checksum="24718033C4FC7D71" modified="2015-04-29" version="1">MATEAEEAAFKQWLESELRSTLKIDDAVMFEYLVGIIALESSDDERREAVESFISELTDVPVDAFLDQVVSRWRAIVISQQAAEKDRQALERKKAQEKVDAISREQTAAIAAEMAASRKEISPEERKRRDAILEQYAYDHGSDEEDYVPEDGETDDIPGIAANNNQAMVADYHLQQRMQAKAEHEQKVARDKAQQDREKAEREKVKQRTQKQERRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2W1</accession>
    <name>A0A0D2X2W1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2W1"/>
    <dbReference type="InParanoid" id="A0A0D2X2W1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="180" mass="19926" checksum="EA4B76609702ECC6" modified="2015-04-29" version="1">MFQLIRPSIHFCQSSNFPHSMFLSRPALGGLVWFGKHAKSRKMTATRKDTARDSLKLVAQNTFVLSRPFITANQELRGFRDIDPESLTTQERERLQKYLQPKYESKKLIVPKSSAPTMARQARRMLGYTPPRPAYTTPVDQAKPAKSSAAAAAKLATAPIPRSAAAAAALSTISAFRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2X6</accession>
    <name>A0A0D2X2X6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270386.1">
        <property type="nucleotide sequence ID" value="XM_011272084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2X6"/>
    <dbReference type="FunCoup" id="A0A0D2X2X6">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2X6"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2X6"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2X6"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="230"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="489" mass="52506" checksum="97DE3E8382CC07A7" modified="2015-04-29" version="1">MVSFQIHFHFKTTSQSSYFHFLFCSIMLATVVSRRVGLLAMPFVQRAQSTAAAAAASAAASATAAASVATTTTSGTADTHSSPTKAGDSASIGKFRAKLAQGPGLEHFMSQKQQSASASAASSCSSGGSAVPEDAEFEGDEEPHEAAHGHTATATATANATTPTGAAVDAAATDARPASTKPARPRLPRWLKTDIPVSASFNQVKNDLRGLKLHTVCEEARCPNIGECWGGGKGTATATIMLMGDTCTRGCRFCSVGTSRNPPPLDPNEPTNTAQAIVKWGLDYVVLTSVDRDDLPDGGSHHFAETIREIKRQKPSLLVECLTPDFRGNLEQIERVATSGLDVYAHNVETVEALQKHVRDRRANYKQSLAVLTHAKKVRPNLVTKTSIMLGLGERDEEVMQTLKDLRAIDVDCVTFGQYMQPTKKHLKVIEYVTPEKFAYWGKVGDELGFKYTASGPLVRSSYKAGEFFLKKILNERKAKQPAEASGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X324</accession>
    <name>A0A0D2X324_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X324"/>
    <dbReference type="STRING" id="595528.A0A0D2X324"/>
    <dbReference type="InParanoid" id="A0A0D2X324"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X324"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF36">
        <property type="entry name" value="CENTRIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="714" mass="76956" checksum="0A884683A6948E55" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X350</accession>
    <name>A0A0D2X350_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348276.2">
        <property type="nucleotide sequence ID" value="XM_004348226.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X350"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X350"/>
    <dbReference type="OrthoDB" id="10044343at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="493"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="855"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1486" mass="159062" checksum="9F227166233BE101" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3J8</accession>
    <name>A0A0D2X3J8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3J8"/>
    <dbReference type="STRING" id="595528.A0A0D2X3J8"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3J8"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3J8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254854" evidence="7">
        <location>
            <begin position="23"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="592"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="881" mass="93559" checksum="42D2F468B3255DA1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3R8</accession>
    <name>A0A0D2X3R8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347051.1">
        <property type="nucleotide sequence ID" value="XM_004347001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3R8"/>
    <dbReference type="FunCoup" id="A0A0D2X3R8">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3R8"/>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3R8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="127" mass="13855" checksum="32BC7FEE643D9F01" modified="2015-04-29" version="1">MAQRAAALGAFRTVVRASERCFTGDKVALTEAKKRIRSEFASRKNEVDPAAITASIKMATDTALFLDKYVVQGAKREQKDQTFELRIRDTTQLDTNPPVKCKNGDKNATPSPAPQGPSPCSSAPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3W2</accession>
    <name>A0A0D2X3W2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346207.1">
        <property type="nucleotide sequence ID" value="XM_004346157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3W2"/>
    <dbReference type="InParanoid" id="A0A0D2X3W2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="33694" checksum="9D34AD4739AE7955" modified="2015-04-29" version="1">MAASSSESTSSLPDSASPSSFAEWSSSLLTSAVTSILDGSSVMDFASTDSTLVQETMASSIGDGSIAATTTETVEISTAAPTLSALETSTDWMSLTTIIESLTPTDESLFPSDESPTESYSETPEPEFPLDLPISAASLFAIVMGGALLAAFAFGVLFYLTRNTIPTAVRAAAAAAAAAAAGGDGRGRSIGWLNRWYRRRRQHRHVTTHLLDEEEAAVRSPSMEMSRPSQVVEMQTLAAGGSALRDPTALRDPTSSSSGMLIDDTSAGASRSTTRDTSTLSSDREKSSVAALLLGRRWMSHRQSRPSSYSQDATGRGNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H7</accession>
    <name>A0A0D2X4H7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345200.1">
        <property type="nucleotide sequence ID" value="XM_004345150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H7"/>
    <dbReference type="InParanoid" id="A0A0D2X4H7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="562" mass="58212" checksum="73EEABEBE7C5E05F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X589</accession>
    <name>A0A0D2X589_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343118.1">
        <property type="nucleotide sequence ID" value="XM_004343068.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X589"/>
    <dbReference type="eggNOG" id="KOG1619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X589"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X589"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="248" mass="27136" checksum="810E39FD2A15F87E" modified="2015-04-29" version="1">MYESIVRPAASWLSGAAAVLALAFGLISTHVMLAMIVSYVYVVSPFTGGQGDGGVSMDHDNPLFLNTHPLCMVLAFCFFMPEAALVYRWLPAERPTKKYVHAALHSAALISSSIGWYVKWYDDEYTTGHVHFGRMHSHFGLIALILFYGQYLAGFGMYLFPGAPLDDRPLYSPYHKFVGVLTISLGAIAAGTGALYIQAAYAENVAINDDNQYYTIWLGLIAAFTAVAVAIGVLLNNKPVKRDLLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5E3</accession>
    <name>A0A0D2X5E3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5E3"/>
    <dbReference type="STRING" id="595528.A0A0D2X5E3"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5E3"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5E3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="317"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="562" mass="60510" checksum="1AED61C7E567BEE3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5R0</accession>
    <name>A0A0D2X5R0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342492.2">
        <property type="nucleotide sequence ID" value="XM_004342443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5R0"/>
    <dbReference type="STRING" id="595528.A0A0D2X5R0"/>
    <dbReference type="InParanoid" id="A0A0D2X5R0"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5R0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="441"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="805" mass="87881" checksum="D3B81A6F448A5B16" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9C811</accession>
    <accession>E9C814</accession>
    <name>E9C811_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004388</name>
        <name evidence="2" type="ORF">CAOG_004391</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348216.1">
        <property type="nucleotide sequence ID" value="XM_004348166.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348219.2">
        <property type="nucleotide sequence ID" value="XM_004348169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9C811"/>
    <dbReference type="InParanoid" id="E9C811"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="225" mass="25072" checksum="82F604539BBD667E" modified="2011-04-05" version="1">MPHVDQVLLPLMFQVLARRLTRAEMANIRAGNSFRFSRRRVKRWTDGRRWGRGYRLASGSFVYKEIDEHGSILRNGLTKVVGEDDDDTSVRTVTYSNTDNNAAELNNFVAPPDLFAPLLNAHARANDEMLLPLIHRLIDLLNVNVADNINPAPPPIAEAPAIVGADVPFDLDSLLLPPFLNDLVDDEPKFADLFIDNVNFDAPVQPADSPMAAGLRFMLDSPVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0Z5</accession>
    <name>A0A0D2U0Z5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterotrimeric G protein beta subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365353.1">
        <property type="nucleotide sequence ID" value="XM_004365296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0Z5"/>
    <dbReference type="FunCoup" id="A0A0D2U0Z5">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0Z5"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0Z5"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0Z5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="37757" checksum="359C68EA4B0F51CC" modified="2015-04-29" version="1">MADEYNQLKATAEELKAKIKADRDSKKDTTLLEAASDVAELPRLSMRVRRSLRGHLAKIYAMHWSTDNRHLVSASQDGKLLVWDAYTTNKIHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLKSREGVVRVTRELASHTGYLSCCRFLSDREIVTSSGDMTCALWDCETGQLRTSFQGHAGDVMSLSLSPDANPNTFVSGACDAQAKVWDIREGRAVQTFTGHESDINAVHYFPSGQAFGTGSDDATCRLFDLRADAELNQYTHENILCGITSIGFSLSGRLLFAGYDNFDCNVWDTLKRTRVAILPSHDNRVSCLGVSSDGLALCTGSWDSLLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U438</accession>
    <name>A0A0D2U438_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349864.1">
        <property type="nucleotide sequence ID" value="XM_004349814.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U438"/>
    <dbReference type="STRING" id="595528.A0A0D2U438"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U438"/>
    <dbReference type="OMA" id="DYTENYI"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U438"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="59713" checksum="A3C015C70B2FEBC1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4X2</accession>
    <name>A0A0D2U4X2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364411.1">
        <property type="nucleotide sequence ID" value="XM_004364354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4X2"/>
    <dbReference type="STRING" id="595528.A0A0D2U4X2"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4X2"/>
    <dbReference type="OMA" id="WLVIANN"/>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4X2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="410" mass="44538" checksum="989F8B4273AA6185" modified="2015-04-29" version="1">MLGACLSALRRVRVTQGSPLLRVLLVAGVFTYGSHSVLTNLSKGDDGRVAYNVASVVLMTELCKLLISCTLALLTLGTRGVVGEVRAGAFKPRFFLLLSVPALLYALNNNTAYYAQQAMDPVSFMVLCNFKIITTAILFRLIMNRSLSRNQWLAMPILLFSSILNSMAGLAKHSSIVDESAQDTNILLKSALYVSPYGLMLMVMYCTISGFAGVYAEYVLKSRMHASLHMQNIPLYLCGVVMNATAYFWSSSSTNAVIDDTALRLSHSATSLVWMLGPFARLFDGYNGWTWVIILTQAGNGLILSVVMKHSTNIVKLFMIALSMLLSTATSILAFDMSLSWEFVLALVLVLWAIALYHTPAPASSAATMSTGPARPVAHGAAAAFGESDQQRSLLPFVHKQGYSGMLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5Q3</accession>
    <name>A0A0D2U5Q3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270129.1">
        <property type="nucleotide sequence ID" value="XM_011271827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5Q3"/>
    <dbReference type="InParanoid" id="A0A0D2U5Q3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1041" mass="111916" checksum="6254E8579C6ACBC4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAX5</accession>
    <name>A0A0D2UAX5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAX5"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="111435" checksum="71D4D005793B372A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE31</accession>
    <name>A0A0D2UE31_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE31"/>
    <dbReference type="STRING" id="595528.A0A0D2UE31"/>
    <dbReference type="eggNOG" id="ENOG502QRY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE31"/>
    <dbReference type="OrthoDB" id="192253at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE31"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="400"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="783" mass="82659" checksum="F0A1AC1964AF96DC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEV8</accession>
    <name>A0A0D2UEV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_004368</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348196.2">
        <property type="nucleotide sequence ID" value="XM_004348146.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UEV8"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEV8"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265556" evidence="16">
        <location>
            <begin position="29"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="936"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE93606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1290" mass="135747" checksum="4340EB9CAB702A74" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFI3</accession>
    <name>A0A0D2UFI3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFI3"/>
    <dbReference type="eggNOG" id="KOG4550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFI3"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFI3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252592" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="564"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="716" mass="76273" checksum="DF18990E1921C235" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFP4</accession>
    <name>A0A0D2UFP4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347412.1">
        <property type="nucleotide sequence ID" value="XM_004347362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFP4"/>
    <dbReference type="STRING" id="595528.A0A0D2UFP4"/>
    <dbReference type="InParanoid" id="A0A0D2UFP4"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="940" mass="104388" checksum="9D9C6206D77D0E62" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHH3</accession>
    <name>A0A0D2UHH3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346868.1">
        <property type="nucleotide sequence ID" value="XM_004346818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHH3"/>
    <dbReference type="FunCoup" id="A0A0D2UHH3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHH3"/>
    <dbReference type="eggNOG" id="KOG2545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHH3"/>
    <dbReference type="OMA" id="EEHTEMI"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75324" checksum="136BF93CE866F6F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJQ9</accession>
    <name>A0A0D2UJQ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJQ9"/>
    <dbReference type="InParanoid" id="A0A0D2UJQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="119" mass="12554" checksum="F1288AE79D40C836" modified="2015-04-29" version="1">MSSKPNSQMDLPASAADPKPNARTASAASFDDVDASQSTKRARANNQQVVDNASHGASQQLTAMKNAQRSLTAVTQGQANVAMPNSGLNQAAQSNEEKTERTLQQKLEQAWAKAPGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKH9</accession>
    <name>A0A0D2UKH9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345616.2">
        <property type="nucleotide sequence ID" value="XM_004345566.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UKH9"/>
    <dbReference type="InParanoid" id="A0A0D2UKH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1876"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1876"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1954" mass="192420" checksum="C40F6CC54EB45286" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKJ9</accession>
    <name>A0A0D2UKJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345624.1">
        <property type="nucleotide sequence ID" value="XM_004345574.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKJ9"/>
    <dbReference type="STRING" id="595528.A0A0D2UKJ9"/>
    <dbReference type="eggNOG" id="ENOG502QVCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKJ9"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253543" evidence="2">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="35905" checksum="E007B89F645E724C" modified="2015-04-29" version="1">MKLTLLLLLVACVGTALAQSSSTVVTVIPVESSGAPAESSGLPASSGLPASSGLPESSGIPASSVPVSASAPANATSAPANVSASVTASPSAKPVVLSSTNDLWALQYMYVMERLDSEFFNTSLDAFTAAQFADAFGAQVPNYLQMINAQVKVHFDTIRDLILLRNATLPENCTFEFGTNWTTTEILQTAASIQTLMVEAYDGVMPLITDAHLQQIAGTIATVKARHAAYLNMLISEMPFPSAFDTALSPSNATDRVFGEYMTTCPQDLNLPIPRDETVKQTTAKPIGGSSAVANATVTASVIASGSVQLSPTVSGGIAPAGNSASTMSLATASVVSLISLVAAVARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKW1</accession>
    <name>A0A0D2UKW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin modifying protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345728.1">
        <property type="nucleotide sequence ID" value="XM_004345678.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKW1"/>
    <dbReference type="FunCoup" id="A0A0D2UKW1">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UKW1"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKW1"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="24850" checksum="6CA1445C984E1C8F" modified="2015-04-29" version="1">MKRMFGMGKPTQPPPTLTDAISNTDARGESIEKKIEKLDVELKKYKDQLAKTRDGHGKQLLKQRAMRVLKQKRMYEAQRDQLMQQSFNMEQANFATQTMKDTITTVNAMKVGVKEMKTQYKKINIDKIEDIQDEMEDLLDQANEVQESLSRSYGLGEDVDEADLEAELDMLGDEFASESDTSYLDDATRAPAAPTGELSSPASGQKAVAVDEFGLPEVPASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UN07</accession>
    <name>A0A0D2UN07_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344373.2">
        <property type="nucleotide sequence ID" value="XM_004344323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UN07"/>
    <dbReference type="STRING" id="595528.A0A0D2UN07"/>
    <dbReference type="eggNOG" id="KOG4414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UN07"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="8">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="907" mass="96239" checksum="69EED7FB684769FD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPU9</accession>
    <name>A0A0D2UPU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Egfl6-prov protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343386.1">
        <property type="nucleotide sequence ID" value="XM_004343336.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPU9"/>
    <dbReference type="eggNOG" id="KOG1306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPU9"/>
    <dbReference type="OrthoDB" id="5983152at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000017">
        <property type="entry name" value="Adhesion G protein-coupled receptor V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265685" evidence="10">
        <location>
            <begin position="30"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1422"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1444"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1502"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1531"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1544" mass="158838" checksum="E233FE4B383E4CA6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR75</accession>
    <name>A0A0D2UR75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR75"/>
    <dbReference type="InParanoid" id="A0A0D2UR75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="145" mass="16638" checksum="A7447FF0C29B3ABE" modified="2015-04-29" version="1">MNHCSLIQSRCRRSQCSCVVPCMKRSVLCLDGRSIAQSWHHHRRHPVPSSASTPYALLVWCKYWLFFLRSGIISGPAVREIKVGQTHHILSDLFRRQQFLLQLNVGLPNPSLVVHDSLRKKLRVLAWELLPFSCSLLLLLLQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USB1</accession>
    <name>A0A0D2USB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343026.1">
        <property type="nucleotide sequence ID" value="XM_004342976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USB1"/>
    <dbReference type="FunCoup" id="A0A0D2USB1">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2USB1"/>
    <dbReference type="eggNOG" id="KOG1163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USB1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="428" mass="48777" checksum="A3EA86314203F041" modified="2015-04-29" version="1">MELRVGNNNNEYRLVRKIGSGSFGDIYLGTSITTGEDVAIKLEPLKARHPQLLYETRLYKILQGGTGIPHVRWYGVEGDYNVMVIDLLGPSLEDLFNFCNRRFTLKTVLMLAEQMLTRLEYVHSKHFIHRDVKPDNFLMGVGKKCHQVYVIDFGLAKKFRDPKTKQHIPYREDKNLTGTARYASINAHLGIEQSRRDDIESLGYVLMYFNRGTLPWQGLKAANKKQKYDKISEKKMSTPIDVLCRGYPIEFQQYIAYARNLRFEEQPDYSYLRNLFRTLFQKEKYANDFVFDWIYVLRQKQIQKEAEAKAALAAQQSLQATGTMTSPDQLAAMQQHYAQQMQQQQQLQHQQLLLQQQQQQQQATSAAMAAAAALQQTGISTAVAPSPGHTGLRENPALGAHSSTNTSMAVMPPSQAPSVMSPQRPPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTH3</accession>
    <name>A0A0D2UTH3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaminyl cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTH3"/>
    <dbReference type="STRING" id="595528.A0A0D2UTH3"/>
    <dbReference type="eggNOG" id="KOG3946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTH3"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253076" evidence="4">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="196"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE98286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="38816" checksum="C944C6C9953DD76E" modified="2015-04-29" version="1">MARWTRLAVLGLLALVLVLVGVAVAERDDIAQPPLEQQQQQQQQQQRSNHNHKHESLRTGRRLLTLDDADDEDQFGSDDDDDDGDDHDGGRHHDGDGHAGAAGRYKKPRPRGSLKVKRAPLTLSTAQVKELSKQIDIGHLWTDLLQPLLIERVPGTPTHQQAAKHIEDTLTALPGWRVTTDTFNDSTPLGVRPFKNIVATLERPGATRRFVLAAHYDSKYFAPPVKFIGATDSAAPCAIMLHLAELISKERVECSASTGDATLQLVFFDGEEAFQTWTATDSIYGSRHLAALWEANDKSESPSPSQLHSTLCGIDTLMLLDLLGAKNPTIRGSFDNTLAIHDSVADIGGDGVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTN2</accession>
    <name>A0A0D2UTN2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346395">
        <property type="protein sequence ID" value="KJE98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341258.1">
        <property type="nucleotide sequence ID" value="XM_004341210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTN2"/>
    <dbReference type="InParanoid" id="A0A0D2UTN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="46434" checksum="6CF94FFF639AAA69" modified="2015-04-29" version="1">MSSSSSSSSSSSRTTQPSTLHEQEQALKIELIKVRLQLAKLESKTRSGRQLSKSEIKTNRQLQARFEYLDCFIDQLRFQQGTAQEEEAASVRVALAEAAAVRQVEEALDRISLSDEAMAAKLESAASIFERLKKLASLKMVQGASLLAEQPMPFLHMLKELCDQAEDKKTEKRRAVDEPKKKIKKKSRVEGGETFAAFLSSCKYHTAALSSGTFALLVDSPDNARDEDSIVADIDLSLATTDNLTRLNMHNHYVLGRRVNKLFNLWRKTGKNIITTYAAHQLSQRLSYRHACRYVSLYKFLSQYPRFKYVSKAWTTLVDFIPDIKSHFEDVPEDRAYFSTLGIDAPLQCQYSLSTAAGVVTSGAVTDDILSVTEAEQGEFERTIIVPTDDDAPLPADDDGDDDGDDEEADAMEMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFJ4</accession>
    <name>A0A0D2VFJ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365031.1">
        <property type="nucleotide sequence ID" value="XM_004364974.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFJ4"/>
    <dbReference type="InParanoid" id="A0A0D2VFJ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="22317" checksum="A6678D5C6845CADB" modified="2015-04-29" version="1">MASLRRTAAGNASQQHQEPVELLDEAEQESILETLAEAGNRVDRLSRTAIAAGAGVAAALFIARLLVMPGAAELTTDALIVEFLAAVSNSLTCLRLICDLKGADPSIPWFRFKYIAPFGHLVGLATLYVHMYGRPAVEQALDTRDLPEQSNSMITLMRHFWVPLVSLIVSLLWIFTEYDVRRTTTDLQELRRARYKYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFS4</accession>
    <name>A0A0D2VFS4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFS4"/>
    <dbReference type="STRING" id="595528.A0A0D2VFS4"/>
    <dbReference type="InParanoid" id="A0A0D2VFS4"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFS4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="119"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="340" mass="36462" checksum="12AE6FC22246A428" modified="2015-04-29" version="1">MLAIAAWLHSLLPERGGQEAGGATGGLMTGASSAIRSSASTRLASTRPHRPVRIVLGLSGSVAAIKAPLLVPLIKQRVAAAFQPADSATSTSVEADIKVEPSHEDSNNLEVVPPSAPIQVEVHVVATEHAAHFFNAESLRSETANQTGVLTDVHEWVRISEQLGSDIMCITLNESLVSKRSSAFLVYLRVGYKKWSKIGDPVLHIALRGWADLLVIAPLDANTLAKLSHGMCDNLLTCIARAWDYTTRPLIVCPAMNTFMWDHPATARQLDMLQSLGMEIVPPIAKRLACGDLGFGAMAEVQTIADFVAERVRTLDLHAIDAANERATGRASSPQLPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFV8</accession>
    <name>A0A0D2VFV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ilvbl protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365119.1">
        <property type="nucleotide sequence ID" value="XM_004365062.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFV8"/>
    <dbReference type="STRING" id="595528.A0A0D2VFV8"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFV8"/>
    <dbReference type="OMA" id="AQMLHVY"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="9">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="7">
        <location>
            <begin position="281"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="8">
        <location>
            <begin position="477"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="641" mass="68212" checksum="8C145B850E253FF9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIS9</accession>
    <name>A0A0D2VIS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione reductase</fullName>
            <ecNumber evidence="18">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_001302</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="15">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="18"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349822.1">
        <property type="nucleotide sequence ID" value="XM_004349772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIS9"/>
    <dbReference type="FunCoup" id="A0A0D2VIS9">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIS9"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIS9"/>
    <dbReference type="OMA" id="VTMAPWG"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000484">
        <property type="entry name" value="Glutathione reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="8 18" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="20">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="19">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="16">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="455" mass="48947" checksum="03681016DBCA9CF2" modified="2015-04-29" version="1">MAAAAFTAVYDYLVIGGGSGGIASARRAALHGAKTALVEYQRLGGTCVNVGCVPKKVMWNTASMAEALHDAPDYGFDVTVKGFSWSSIRTKRDEYIKRLNGIYQGNLERDKIDILRGRARFVGPKQVSVDGKIYSAKHILIATGSYAKLPDVPGAHHGITSDGFFELNEQPKKVAVVGAGYIAVELAGIFRALGSEVSLLVRHDGVLRKFDSMLHKGVEEELTASGVNLLLNTHVSSVTKDDSGHLSLALTNGTTQSGFDCLVWAIGRSPTIEDLDLEKTGVSLDKDGLIKVDEFQNTTHEGIHAVGDVASHWQLTPVAIAAGRRLSERLFAGKTDLKLEYENIASVVFSHPALGTVGLSEEDAIAKHGKDNLKIYSATFTNMYHSMTTRKTKTRVKLVCLGKEEKVIGVHVIGIGADEMIQGFAVAVKMGATKAQFDDTVAIHPTASEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJD3</accession>
    <name>A0A0D2VJD3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364315.1">
        <property type="nucleotide sequence ID" value="XM_004364258.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJD3"/>
    <dbReference type="STRING" id="595528.A0A0D2VJD3"/>
    <dbReference type="eggNOG" id="KOG1698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJD3"/>
    <dbReference type="OMA" id="NILMRVD"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJD3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37518" checksum="111DB84FB1C88561" modified="2015-04-29" version="1">MQSAAVVAVARRGIATASSAALAGAAAAKPPPPQAKRTAPAGGAAAAAAPAKEAAPTKDAARQALRTFLAEEPFETSKTDMLSWLKRREVRLQRYNAAPVPAFDVGSIISVKYRTSMTGEDANRVTKYMGIVVKKRWNLGLSSWFTIRNVIEDEVVEFTFPTHSPRVMDITVLRPGRADRNALSKMLDRLPKKHSTFTLEGMGGRTEKQVIEVTRRAAQAKTEAAVSAEFLRARGQSLALSTVAKMRELAEKDGRQVSVDEAALAAQRAYDLATKRNKSTTVVPPASAHASRKPSGLPGISAPTATAVASLASVDINAAENMLRRENIAALYGVETLEGVDKAVQATSSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKY7</accession>
    <name>A0A0D2VKY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Guanylate cyclase</fullName>
            <ecNumber evidence="2 11">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_002000</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 11"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364868.1">
        <property type="nucleotide sequence ID" value="XM_004364811.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VKY7"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKY7"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.100">
        <property type="entry name" value="Glycine betaine-binding periplasmic protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253675" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="45"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="579"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="982"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1381"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE90742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1406" mass="152331" checksum="8EB809348EC52A96" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM03</accession>
    <name>A0A0D2VM03_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mmaa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Interacts with MMUT (the apoenzyme form); the interaction is GTP dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349051.1">
        <property type="nucleotide sequence ID" value="XM_004349001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM03"/>
    <dbReference type="STRING" id="595528.A0A0D2VM03"/>
    <dbReference type="eggNOG" id="ENOG502QR2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM03"/>
    <dbReference type="OMA" id="HWEEEVM"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000647">
        <property type="entry name" value="Methylmalonic aciduria type A homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="222"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="495" mass="53418" checksum="C60B9F254956D359" modified="2015-04-29" version="1">MLLASSKLACAATPLLRAQRTASTRLALLTASSWTRAQAAPLQNDQRRGVSSSGTRPCLGLGSLPSAPSTRAGLHQHATSSSTPSMSATEREECSARLSVPTRSVSTQSTPVTVQAPVQPQAAKKTENDAFNVDHLLHLKEADQAWLQKLYDGILQQDRSALARGITLVESWRRDHRRVAQNLLDRILDVLHDRWSHVQSLGSRAVSTVTLKNNQTTTTLPTPFRIGLSGPPGAGKSTFIETFGMFLVNQGLRVAVLAVDPSSSVSGGSILGDKTRMTELSRNDAAYVRPSPSRGSLGGVTRNTSDAIVLCEGSGYDVIIIETVGVGQSETAVADMVDLFTLIVPPGGGDELQGIKKGIVELADFVIVNKADGDLLPAARKAKSEYTSAMKLLRPRTASWTPEIAMLSSLDSTGLADAWKLMLQFYDSQMKGGEFFLKRSQQRKRLMWKHVSDGILERFQAHPEVSRVIAGAEQQVMQGLVAPGLAADELLDRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM34</accession>
    <name>A0A0D2VM34_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270194.1">
        <property type="nucleotide sequence ID" value="XM_011271892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM34"/>
    <dbReference type="InParanoid" id="A0A0D2VM34"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM34"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="258" mass="28424" checksum="9E67EC71648339C9" modified="2015-04-29" version="1" fragment="single">MLQGKEDFVAFERSLVQQVDALRRVRQRYMALLGVLLLWHLFNVYRWWTAVVPAANDDPSRPPASSAQTDDAATAGLHGALDEAARLQLISTDEPNQHYFSNFLFGEPNLLFSWISLIVFFLTGSYQNKINAPHILITRVKRALRTFDLTCDSNGKLILPNRFRSKGRNASHNSYRTVVGTPSSAFSSSSHMNVAGTSDNLPASLVSTSEPTQVAAALRTQLAHGNAIDDSFFKPPAPVTTTVLPPDAVLRSTRASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPC7</accession>
    <name>A0A0D2VPC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_003311</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364150.2">
        <property type="nucleotide sequence ID" value="XM_004364093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPC7"/>
    <dbReference type="STRING" id="595528.A0A0D2VPC7"/>
    <dbReference type="InParanoid" id="A0A0D2VPC7"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE92312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="361" mass="41528" checksum="5AAFC74052520510" modified="2015-04-29" version="1">MGPARVARQPSRRYAPRYRACTAHAQLMRGQFLKLFDFFMPSVAKKFEPEFDALVHLMIYRLSVYAKDATYGQGLLSLKYADARRLREDDASPLRTAMPIAASAATMGASAGLTKWQKVLYGLAYIGGKWAWTRVNDISSYWQWSEREENDPLKRLWRLKENLDKLYKFLTVLNTILFLRDGRFPFLIDRILRIRQVYSTGSLSRQVSYEFMNRQLLWHGFAEFLLFLLPLINLQKIKNVALRILYFTTSMQQQQREQRLQKQLHQKGQQLDPKAALEIQRQQRLRDFEGPCGICGESPIGTPSVVPCGHVYCYVCIASNCLADSGYRCLRCNAPVDNKFERFVPPSPPASPSSSLARHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQP2</accession>
    <name>A0A0D2VQP2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363608.1">
        <property type="nucleotide sequence ID" value="XM_004363551.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQP2"/>
    <dbReference type="FunCoup" id="A0A0D2VQP2">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQP2"/>
    <dbReference type="eggNOG" id="KOG0945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQP2"/>
    <dbReference type="OMA" id="RCYRFAF"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253791" description="holo-[acyl-carrier-protein] synthase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="5">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="287" mass="31439" checksum="5261AB7C34378FD2" modified="2015-04-29" version="1">MITLLLLRIAFNVSRWTTPDDDGEWAAACSLADPADVAGRIDKFVFKRDAKLALAGQLLIRAALRQIAAAELGLLTPAELSARLRRTPTGKPYLTAAADSSIAHPEVHFNSSHHGDYVAVVAAVAPNCMVGVDVMRIDAPPARESIDSYIGVMKTAFHPDEFRYIQSQPSHEIAEKSNRLHAFYRFWTLKECYVKAIGAGLGMELSQIRLTEDASIPLDLRIQQITSNVTCAVDNIPLDRWHFEQQYLDELHPIAVAMHAPNGGFTSGRFSILPSFSSLLTLAGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQX6</accession>
    <name>A0A0D2VQX6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347837.1">
        <property type="nucleotide sequence ID" value="XM_004347787.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQX6"/>
    <dbReference type="FunCoup" id="A0A0D2VQX6">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQX6"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQX6"/>
    <dbReference type="OMA" id="VEITRCV"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="267" mass="29281" checksum="1A3E0B2EE531F9AE" modified="2015-04-29" version="1">MDRFDVSSIVATHGAPAVVGGTLAALAAGFVAWYMSPFVTLAFSVAKGYALSIFLGLPEQRLLAFVQKNAEKGNAQAVLDCIDRWCWDGQWMMNIGNRKGEILDQAVKDAQPMNCVELGGYVGYSAIRIGRLLPKGAQLVTLEISPKYARIAEAMILHAGLEKTCRIVVGDSALNIPKLKEITGKDKIDFAFVDHFKTLYLRDLKIMESCDLLKSGSVLVADNVIFPGAPDYLKYVRGLPEVYQSEFHPAQVEYSTITDGVEVTTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRD7</accession>
    <name>A0A0D2VRD7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348040.1">
        <property type="nucleotide sequence ID" value="XM_004347990.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRD7"/>
    <dbReference type="InParanoid" id="A0A0D2VRD7"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRD7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="779" mass="84646" checksum="077278FE6278F246" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRP1</accession>
    <name>A0A0D2VRP1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348154.2">
        <property type="nucleotide sequence ID" value="XM_004348104.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2VRP1">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRP1"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRP1"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1835"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1906"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="734"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1244"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="378"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1292"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1939" mass="210679" checksum="599987942FE546E9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRV3</accession>
    <name>A0A0D2VRV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin folding cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348236.1">
        <property type="nucleotide sequence ID" value="XM_004348186.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRV3"/>
    <dbReference type="FunCoup" id="A0A0D2VRV3">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRV3"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRV3"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="234" mass="26331" checksum="B12CF00A926089D6" modified="2015-04-29" version="1">MSTINLFVTSSLSSQAIARQARFDKALTIRQLKVKLEMMVGSSNSKMQLQLFDPRDKLAGDMADDDAMLGAYPAEDNWRIHVVDLDPSKRVGEFEDLSQVEKFELNEEQYDQRADTVRSFKRNNKLGRFADDAKDPNDEGKEEAAAITVGQRCEVTVDASMAKRGVVRFVGRTQFKPGYWVGVQYDEPLGKNNGSVDGVKYFVCPQSYGAFVRPSYVRVGDYPEVDLDSDLDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS63</accession>
    <name>A0A0D2VS63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347348.1">
        <property type="nucleotide sequence ID" value="XM_004347298.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS63"/>
    <dbReference type="STRING" id="595528.A0A0D2VS63"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS63"/>
    <dbReference type="OMA" id="HRANDIR"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="5">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1154" mass="124770" checksum="BA8B888F9A4D2FEA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS83</accession>
    <name>A0A0D2VS83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WDFY3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2VS83">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VS83"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS83"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2885"/>
            <end position="3027"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="3055"/>
            <end position="3348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3481"/>
            <end position="3522"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3677"/>
            <end position="3737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2262"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2856"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2268"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2863"/>
            <end position="2877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3741" mass="405162" checksum="320B72A748DBB526" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSF5</accession>
    <name>A0A0D2VSF5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347466.1">
        <property type="nucleotide sequence ID" value="XM_004347416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSF5"/>
    <dbReference type="FunCoup" id="A0A0D2VSF5">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VSF5"/>
    <dbReference type="eggNOG" id="KOG0654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSF5"/>
    <dbReference type="OMA" id="NDINGNM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSF5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="305"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="398"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="402"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="580" mass="64826" checksum="04AD3512596EF21D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTG4</accession>
    <name>A0A0D2VTG4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005174</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346859.1">
        <property type="nucleotide sequence ID" value="XM_004346809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTG4"/>
    <dbReference type="FunCoup" id="A0A0D2VTG4">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTG4"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTG4"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="511"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="308"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="771" mass="84996" checksum="694DA3454565A123" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTZ7</accession>
    <name>A0A0D2VTZ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346068.1">
        <property type="nucleotide sequence ID" value="XM_004346018.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTZ7"/>
    <dbReference type="InParanoid" id="A0A0D2VTZ7"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="1">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="266" mass="28785" checksum="24C89433042FA3D1" modified="2015-04-29" version="1">MSSSDDDNALSLFDLETAPLDFFLLPEPAAAAALHLNLNVEEDDEEELLDNDDDDDASPLATPWDACFSPEDFDQLASVITASELFDFGAQEDAAKVPLPQATGAMTSVKPLDNGAAAKLRTSAKQSLKQSLPAGSKVPVVATSGLNLRHGMSSSVSVLALLRSHVSDRAAAAQLDKLTPGDLENMGTRERNQLYKQLRLSADVLAQVKGMRRRVKNCQAANTLRRRRDTEMQALHERVRLLEQENALLRAQLASQPARANLALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVA5</accession>
    <name>A0A0D2VVA5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Progestin and adipoQ receptor family member IIIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345441.1">
        <property type="nucleotide sequence ID" value="XM_004345391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVA5"/>
    <dbReference type="STRING" id="595528.A0A0D2VVA5"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVA5"/>
    <dbReference type="OMA" id="EVPSWYA"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVA5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="288" mass="32903" checksum="7B3B0090F51528B0" modified="2015-04-29" version="1">MASLHPNSVLLHKYSEIPPFLQGNPHIKDGYRVFLSYPMCLRSLCVLSNEFVNVWSHLVGFLLFVGLFLQDQASVIETSGGDATDRMVISTGLACFQICMIFSASFHLFHCHSEDACRRWLRLDLLGISVAVCGCYFTGIYYGFYCLDYFRNMYFALCSVLTLATVSFQLHPNFDTPHWFERRLALYAAIVMFGIVPTMHWAIIYGGEAGEVQLFLPKVVIMYLLFLIGVIFYITRFPERSFPGMVDIFGSSHQWWHVFVLAALLYWHNAGLEVFAYRKTMPCVQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVT9</accession>
    <name>A0A0D2VVT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVT9"/>
    <dbReference type="InParanoid" id="A0A0D2VVT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="106" mass="11494" checksum="956E5ACB68805C7A" modified="2015-04-29" version="1">MQSIPSSPLNVVRPLVRLPAPTQRSAKLRMLQKTKHSTFGNKRSCNNAIRNGQNEADNMPAPICVGLVVTFPAIPSPNSASLASQSNAHVPFLADVCQRIVSVYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXQ5</accession>
    <name>A0A0D2VXQ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_006786</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXQ5"/>
    <dbReference type="STRING" id="595528.A0A0D2VXQ5"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXQ5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VXQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000055">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="90"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="750"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE96462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="975" mass="105615" checksum="D5147E38577C084C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYK1</accession>
    <name>A0A0D2VYK1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYK1"/>
    <dbReference type="InParanoid" id="A0A0D2VYK1"/>
    <dbReference type="OrthoDB" id="416119at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1420" mass="155029" checksum="02BFB0806079427E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH21</accession>
    <name>A0A0D2WH21_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_008403</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH21"/>
    <dbReference type="STRING" id="595528.A0A0D2WH21"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH21"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="742" mass="82499" checksum="EF5BB462CF5258DC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI37</accession>
    <name>A0A0D2WI37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI37"/>
    <dbReference type="STRING" id="595528.A0A0D2WI37"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI37"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="598"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="856" mass="90928" checksum="0EA7E8160B198B54" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WII8</accession>
    <name>A0A0D2WII8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365315.1">
        <property type="nucleotide sequence ID" value="XM_004365258.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WII8"/>
    <dbReference type="STRING" id="595528.A0A0D2WII8"/>
    <dbReference type="eggNOG" id="KOG4508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WII8"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WII8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="616" mass="65913" checksum="523BC93AA18066CF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIT7</accession>
    <name>A0A0D2WIT7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_001246</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIT7"/>
    <dbReference type="FunCoup" id="A0A0D2WIT7">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIT7"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIT7"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIT7"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="113"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="45350" checksum="C273BE4294DE0B8D" modified="2015-04-29" version="1">MTMSGGVRHQSASASAKTECCGGGCHAPKQPNADIAAAAAASGHASSINAQPPTAPKKKTTNEAFNELTETARRDIRIRHDWTRAEIQEIFDTPLLDLMYRAATVHRTHHDPRQVQQCTLLSIKTGGCSEDCAYCPQSSKYTTNVKAERLMQLQSVVDAARKAKEAGSTRFCMGAAWRDVIHRKSNFAHVLEMVSEVRSMGLEVCATLGMLSPEQAVQLKNAGLTAYNHNLDTSREFYPKIITTRTYDERLNTIANARDAGLSVCSGGIIGLGEDLNDRVGLLHTLSTLPTHPESVPVNALVPVPGTPLGDREKVKIWEMVRMIATARILMPGSMVRLSAGRVNFTPIEQALCFFAGANSIFTGDKLLTTANNAFNDDQTLFNLLGLVGKEPNFDQGPVRATESAEVESDASSAEPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ07</accession>
    <name>A0A0D2WJ07_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365558.1">
        <property type="nucleotide sequence ID" value="XM_004365501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ07"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ07"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ07"/>
    <dbReference type="OMA" id="CALFFDR"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ07"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="326" mass="36354" checksum="B0CC7115D41C19B2" modified="2015-04-29" version="1">MAAHIIPRVMRPAFAASTTPASADMPRRVRILQFNTLADGLSDAFPLVEKRLLSWPHRSALLLQEILAHDPDIACLQEVDHFDDFFESELAQHGYTGIFKPKRDDGKADGCATFFKRSKFEVHIRQDLEYRKVIDDKDVSQVAILTVFKPAGVAPNADGIVSREGLFAVLNTHLKAKDEFEATRVKEVSAVLDVLAKLQAQFPRIPMVISSDMNTEPTGPVYELLEKGLVSFSGSSYTHRLSLKSAYALYKDGGGEPDYTTWKIRPPVEVARVIDYLWYTPETLLPIQLLALPGPETLPPTRLPSENYPSDHFALLAEFGFLPASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ72</accession>
    <name>A0A0D2WJ72_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365694.1">
        <property type="nucleotide sequence ID" value="XM_004365637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ72"/>
    <dbReference type="InParanoid" id="A0A0D2WJ72"/>
    <dbReference type="OrthoDB" id="5825849at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10497" checksum="2E2BF9A67604BCAB" modified="2015-04-29" version="1">MLAPSGPALAKFRHISIATRQIPTAKLRESLMDRSDLCDGAMQKLMVCWKQNNHLDKPCSQLLAEFQTCINELAVPKAEARSAAQFFLRHQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJA9</accession>
    <name>A0A0D2WJA9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJA9"/>
    <dbReference type="STRING" id="595528.A0A0D2WJA9"/>
    <dbReference type="eggNOG" id="ENOG502S36N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJA9"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJA9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08231">
        <property type="entry name" value="MDR_TM0436_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="467" mass="48853" checksum="D745C145BB41B399" modified="2015-04-29" version="1">MLTNAAATSAAAAHFHKDLHPHAHYHPTISSSSSSSSSSSGSTTSSSSQDTTAEAIAAAELAGVATPTTTTTAKVLRMLFEGPGKPFVAQETANKEITLGAGEILVRLTMATVCGSDLHTASGRRAAYLPSVLGHEGVGVIEAVGADTTVFTADAAELNLATCASASAASEQQQQQAPNAMGNLVSLQAKTSVLANLVGRRVTWTLTNTCGHCLPCTEWHIPQKCTSLFKYGHAPLEDACGLNGCFASHILLRQGTAVILLPEDLSDNVAVPANCALSTMVAVVEKVPVDAKTVLIQGAGLLGVYGAALLKDRGVATVYVSDNIDSRLELAAEFGAVPVKGAEVAALKPQSVDAVIEVAGVASIIPEGIRLLRPAGTYVFAGMVHPETKLGITGLDVIKNCLTICGVHNYASHHLVDGIEFLRKTANRHPWSKLVSPPVPLTQLDQAFELSNQRQWHRVAVQLDQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJD5</accession>
    <name>A0A0D2WJD5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364333.1">
        <property type="nucleotide sequence ID" value="XM_004364276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJD5"/>
    <dbReference type="STRING" id="595528.A0A0D2WJD5"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJD5"/>
    <dbReference type="OMA" id="NEVIFMM"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJD5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="334" mass="35427" checksum="1D05128FA93FA99F" modified="2015-04-29" version="1">MSNQQLSSRSTCAQALEAFGSALPLTSSRVLVTGATAGIGIDTAAALAAAGAAVTFTARSDASAAAALEQITAIATQLQATVPKLVALAPHSPLKIDHVVLDLGSLASVKAGVEAFTSKHPEPLDILINNAGVFGMPHTLSKDGYEMHFAVNHLGHFLLTSLLLPAVLASKHKRIVNLSSVSHTTPSTLNFDDLLKRERSYLALHAYGNSKLCNVYHANELHRRFHDAQGLSTVSVHPGDMISTSISRQRLLWRFVFFLASPFTKSVTQGASTTVVAALASESVIPSSSYLIDCKVTPTSAAARLQEPAVRLWDLSVELVKQYLTPEALALVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKI2</accession>
    <name>A0A0D2WKI2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKI2"/>
    <dbReference type="STRING" id="595528.A0A0D2WKI2"/>
    <dbReference type="InParanoid" id="A0A0D2WKI2"/>
    <dbReference type="OrthoDB" id="1735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="39"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="261"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="491"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="78939" checksum="2872FCE6A77F06AE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKY9</accession>
    <name>A0A0D2WKY9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364587.1">
        <property type="nucleotide sequence ID" value="XM_004364530.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKY9"/>
    <dbReference type="FunCoup" id="A0A0D2WKY9">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKY9"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKY9"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKY9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="235" mass="25704" checksum="89E9F0724B5371D0" modified="2015-04-29" version="1">MSERYGFSLTTFSPSGKLVQIEYALNAVQGGTTSVGIKAVNGVVIATEKKLPTALIDESSLQKVSSINDKVGFVYSGMGPDSRVLLRKARKIAQQYYTTYGESMPTSQLVREVASVMQEYTQSGGVRPFGVSLLVAGYDSVKGPSLYQVDPSGSYWAWKASAIGKNMLNARTFLEKRYTETIELEDAIHTAILTLKEGFEGQMTEHNIEIGIADQKGYRVLSMAEIKDYLSVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL83</accession>
    <name>A0A0D2WL83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL83"/>
    <dbReference type="InParanoid" id="A0A0D2WL83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="118" mass="12830" checksum="53C9ED9D2A78F5D6" modified="2015-04-29" version="1">MQCVVLDAVEVLVALAAVRHKTHVLFLGAVDDANVVENKFVGEPMRFLAERASCAARPTTQVITVLATASGLTTRSCSHQLSHSRRCRKLRVVGIVAVLVLLLFAEIKVLWIAELVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLJ9</accession>
    <name>A0A0D2WLJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLJ9"/>
    <dbReference type="InParanoid" id="A0A0D2WLJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="342" mass="38501" checksum="C0015F7A59939F18" modified="2015-04-29" version="1">MSQANKLKKKTVQAPQREKRPVDDPAAPDSPKRERIESTSENLTRAIMHIAVYSGSTMPTIFLDELRSALLAYPPSSEDAPRICKLIASRLTSGARACISRLAEDAPEHNDPELLLEHIKNHFGPLRGRVEAFAKLEAMKTQTILEVCDTAEALLDQDQSEFVDSAAVLLAVSNALPPAQREIALRTVHPRDADAIRALVAKLREETLNLRAIEQIQDQYHPRQQQQQQQQQQQQQQQQRRQQRFSNNRANRAQAAVRCGHCRRTGHATHECRYFRSDINNNNNNNNNNNNNNNNNNNNNNNNNNNNFDSNHSAHGYGSSFAPRGQFSRPASGNQRQGLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM28</accession>
    <name>A0A0D2WM28_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363732.1">
        <property type="nucleotide sequence ID" value="XM_004363675.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM28"/>
    <dbReference type="FunCoup" id="A0A0D2WM28">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WM28"/>
    <dbReference type="eggNOG" id="KOG4148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM28"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="110" mass="13008" checksum="2A94D90C83331DDC" modified="2015-04-29" version="1">MVHPSLSEHLHNDECNNVIQQLHQCHSTHSVAKFWGACNDLKNALDDCLGREFEVRRLRNLEEARERNRRVDEARALLLPMSKSDREDLTRRQTERRQNWERTHAEGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMQ2</accession>
    <name>A0A0D2WMQ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMQ2"/>
    <dbReference type="STRING" id="595528.A0A0D2WMQ2"/>
    <dbReference type="eggNOG" id="KOG4551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMQ2"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMQ2"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="267" mass="28770" checksum="DC896920662DAD39" modified="2015-04-29" version="1">MVARVTDGVLDHFQSSGSLSAHWMTSTLITTSVDGVPIEVHIQAPVAVQDDMNPTLQDTQGGVATRLRSSALLQSSGSRRARPINAIRQVTVSRASARNRTRPSLLLVIAMGLTVASVVLAAMDPARTSAIAFGLLATGRPPASLWWCGLLAMAVMAWAVIFWLASTTVHQETITVVPGLGIELTVVKGLRRRSTTTFLDAAQVRDVVINEVITMHRVISVLVVLASTHDAASGSVERVVPVFRHLHPRLAELRPIAKALRKWCELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNZ2</accession>
    <name>A0A0D2WNZ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364091.1">
        <property type="nucleotide sequence ID" value="XM_004364034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNZ2"/>
    <dbReference type="STRING" id="595528.A0A0D2WNZ2"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNZ2"/>
    <dbReference type="OMA" id="FCDPLTM"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="252" mass="25869" checksum="960E83D317407377" modified="2015-04-29" version="1">MSLNSQLLNGKVAIVTGASRGIGREIALHLGAQGAAVIVNYASNANAAKEVVDAITKAGGRATAVQASIGRDISQGNKLVQAAVDAYGGLDILVNNAGVYLGGAGSEGVTEEQFDEMFAVNSKGPFFLLRAASKVIRNNGRIVNISSASLASGAVSLFGAYAPSKAPLHEYTKLFAAELAGRGVTVNTVMPGFTATDMLSDKILEIAKASSLFKRVGTVEDVAVVVDFLVSPTNNWTTAQSLHVSGGGTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPP7</accession>
    <name>A0A0D2WPP7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPP7"/>
    <dbReference type="InParanoid" id="A0A0D2WPP7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="159" mass="18210" checksum="556F8C1A8F3FF457" modified="2015-04-29" version="1">MLLVGNRFPSRFFVFLAFSGVMHSKTHRSMLLDVVHFLTHGCHELVSGAPELDGQGHVRCADCWRNRPHTSCCFEGMREDVSFGVVLCFCFSVVRDLVVIACLLSPHTCRIRNTLFTPKQPAQARECSHTFGHEKMRPFLRCYSCYCCEYAHSMDQDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPW5</accession>
    <name>A0A0D2WPW5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363467.1">
        <property type="nucleotide sequence ID" value="XM_004363410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPW5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPW5"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPW5"/>
    <dbReference type="OMA" id="MAMEAIG"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="332" mass="35008" checksum="0D9620600119DF89" modified="2015-04-29" version="1">MANASANVPPPEVSTPTTSPAQSADPNQPSRSFWGRAAAWTKRYVRRLRGQGSHAHPFPRRPTWRTIYATFIGSFTGIAACAALQYNASFIEDNDLAMLIGSFGATAVLVYAVIDSPLSQPRNVFFGHILSAFIGVCMEKIFGQSPSTLWLSCALAVSLSITAMQLTRTVHPPGGATALIAVTGSQTLRDLGFLYIVIPVGAGVTLMLLIALLINNIFRSYPLFWWRPRKTARVVAVPEPAPGVLPMSNTPVDVLVSTPPAPSSTQQLAAPVAVPGASPAAMPSSSNLYARPASLSASSSSSSSDSTETAELGDITAAEGVQVDETRIDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ47</accession>
    <name>A0A0D2WQ47_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270359.1">
        <property type="nucleotide sequence ID" value="XM_011272057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ47"/>
    <dbReference type="InParanoid" id="A0A0D2WQ47"/>
    <dbReference type="OrthoDB" id="2016662at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="80" mass="9302" checksum="F69EA0D22D527B3A" modified="2015-04-29" version="1">MIAFGRSRHIPNLKLLAAPAPWLPYLLANLAGLYAGVTLVTLRRRWHKEKHWDEHPGEWPPIQRPFFYLGTYLGDPPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ98</accession>
    <name>A0A0D2WQ98_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347281.1">
        <property type="nucleotide sequence ID" value="XM_004347231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ98"/>
    <dbReference type="STRING" id="595528.A0A0D2WQ98"/>
    <dbReference type="eggNOG" id="ENOG502RZAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ98"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF32">
        <property type="entry name" value="AGAP006029-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="28217" checksum="35F7E6D664568666" modified="2015-04-29" version="1">MQGFTFARLRRSRSLLTAVVAIILFVIYYLLSTRSWAWYNHVEPNTQIVCDMTDEDYESLMDMGERLIRIFDKLHIKYWLVYGSHIGALRYQGPIPWDTDIDLGIEWETLKPHYPDAFFAACRAEGLRVDYRGWGGFFRIENDRSRSDLMLFTDYWGNGWMNRMGIESWLFFINYWTYHIFPAALVRDPLPEYKFGRLQMTSTHDGIQVLKYHYPHDWEREVRPTGCENAVIRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQP9</accession>
    <name>A0A0D2WQP9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prominin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347968.1">
        <property type="nucleotide sequence ID" value="XM_004347918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQP9"/>
    <dbReference type="STRING" id="595528.A0A0D2WQP9"/>
    <dbReference type="eggNOG" id="KOG4331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQP9"/>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQP9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270119" description="Prominin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="95009" checksum="205F0756C5B83BCE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR16</accession>
    <name>A0A0D2WR16_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR16"/>
    <dbReference type="STRING" id="595528.A0A0D2WR16"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR16"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="825" mass="92861" checksum="A6972A9F64EDF8AE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR70</accession>
    <name>A0A0D2WR70_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348205.1">
        <property type="nucleotide sequence ID" value="XM_004348155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR70"/>
    <dbReference type="STRING" id="595528.A0A0D2WR70"/>
    <dbReference type="eggNOG" id="KOG2934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR70"/>
    <dbReference type="OrthoDB" id="422700at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="242" mass="26862" checksum="15EB549F946D9818" modified="2015-04-29" version="1">MSIYHEKQSMQLCAMHAINNMMQQQVCTRADLEQIAAGLHATTCDAAAAAAAVAATTTTTTTSTDDNDSTMTKPDSISWTERIGRWWGNPHRSVLGTGNYDANVLAAAVEVFMGMEVKWFDVRKPVREICLEAEVDQREEQLVSRSTAASHSKPSSALGEGSQRQPPRPFGIFVNIDRPFLAFGARHWFAVREIAGVYYNLDSTLDEPEAFASVDEIYEFLQELVHVKRAQLLLVRPRATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR94</accession>
    <name>A0A0D2WR94_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348255.1">
        <property type="nucleotide sequence ID" value="XM_004348205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR94"/>
    <dbReference type="FunCoup" id="A0A0D2WR94">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR94"/>
    <dbReference type="eggNOG" id="KOG3210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR94"/>
    <dbReference type="OMA" id="GMIMLAD"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000041">
        <property type="entry name" value="Glutamine amidotransferase subunit pdxT, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="220" mass="23836" checksum="9D7781281ED64C6F" modified="2015-04-29" version="1">MASPAVKIGVLALQGAFIEHIHVLGRIENVTAVQIRTPAEVNDPTLDALIIPGGESTTMGLVAERSGIVEPLRLWAHQGVKPVWGTCAGMILLANSALQMKIGGQPLLGGLDVCVDRNHFGAQLQSFEMPVSIPVLGEEPFQAVFIRAPVIVSHKPNVTVIAKLEKKNADDEHERIIAARQSNLLATAFHPELTGDSRFHRYFVEMVRTSKLARQQTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRL7</accession>
    <name>A0A0D2WRL7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STE/STE11 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRL7"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRL7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="2121"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1741"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1743"/>
            <end position="1762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2385" mass="250257" checksum="08B803B7120DD0E9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRN5</accession>
    <name>A0A0D2WRN5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_005216</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346901.2">
        <property type="nucleotide sequence ID" value="XM_004346851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRN5"/>
    <dbReference type="FunCoup" id="A0A0D2WRN5">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRN5"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRN5"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRN5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="16">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="16">
        <location>
            <begin position="454"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE94590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="714" mass="77632" checksum="CD8868598316ADD9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS63</accession>
    <name>A0A0D2WS63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS63"/>
    <dbReference type="FunCoup" id="A0A0D2WS63">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WS63"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS63"/>
    <dbReference type="OMA" id="ILGHAIC"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012745888" description="GDT1 family protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="289" mass="30924" checksum="ADD6B9D4D9121AE1" modified="2015-04-29" version="1">MLAVLLGFVAIAADAQEAEQAVNELANAPNDQVDANNANAYDPNAYDPNAPSGWFTGTKKKGFASAFVASLSVIIVSEIGDKTFFIAAIMAMTHPRKVIFIGAIAALALMTVLSVAMGFATTIIPRYITYYASTMLFVFFGLKMLRDGWKMSPDEGQEELEEVTLELKQKEQELESRQHANADVESGGLASSLRRLPGLIPPVMMQAFVLTFLAEWGDRSQITTIILGATEDPIGVSVGGTLGHALCTGLAVLGGQLLAKRISVRTVTLIGAVLFLLFALINLVQSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU18</accession>
    <name>A0A0D2WU18_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345187.2">
        <property type="nucleotide sequence ID" value="XM_004345137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU18"/>
    <dbReference type="InParanoid" id="A0A0D2WU18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="472" mass="52942" checksum="7F291EC6CF9061CA" modified="2015-04-29" version="1">MSTAAVPQTEMQREAFSDDHLLFCGLDTDDATKQRQQQPFVARPDPGTTFTISQDDLDGLYNFPDPFKGLRREHGRTIDLVDRKLPEEIFLDLLGSNKSPKPRYLAGVGGAGKSSIMLMLAVLAMRHNKALFAPASAPAPASTSTSPLVASAPGPARASFDGVIFLIYQPATYSFVDDTAELAAFGLIYEMQVNNRRFLQSRMFDEPAFEVLKDAFVRRKTSSRDSEASLDQWGRIKAALKSLESQSHRFRVLVLIDQWNAIIEANALPVGDRDKLEADHPAQDFSRLDASFGCSLFVTAIGSSLSNGSVEVWCDAQAGDAKVTVQPLTPEEAETLRAIWYYRSPSLAVTREEMQRQFLDLGGVVHILQWYASSHFKNNFNSDLQDMYWSYYGCRLDRVRKRATSKRRLVEDLTAIFVHGQTLETLDDVWLETNMVKRDPDDPRRLIPVSPCTRRAALAVLNQMMTDPRFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV82</accession>
    <name>A0A0D2WV82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spinster like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345161.2">
        <property type="nucleotide sequence ID" value="XM_004345111.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV82"/>
    <dbReference type="FunCoup" id="A0A0D2WV82">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WV82"/>
    <dbReference type="eggNOG" id="KOG1330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV82"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="57031" checksum="7681BC3B40EEDA85" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVK5</accession>
    <name>A0A0D2WVK5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVK5"/>
    <dbReference type="InParanoid" id="A0A0D2WVK5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVK5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="469" mass="50782" checksum="1533692C792E7E4B" modified="2015-04-29" version="1">MNHHANASASSSSRQSRGPLQELSSNVLNAEPAPNVELVRKVDEFYVEELVRAFQTNPDLFHSANQWLALNINSERLPEYSAEQVELYERICRYLNEAIRGVANGDQTGTAVTGALERRASGPATWDGRDTPNEDNRCFVFLTAEIERWTDNETWGGSFRAGNWFKYPSADVAGRWKYRCTSADGLCGIVVYTGPPAVPWTRPCTLERLFTLLGMTLFVAVVVLALTHSVLAGTWDSSACKYTTTAGTSFTVSAFHRDQPWSIPGVSSTGGPDGYNYLYNFCPGLGTQIGTCRSTDLVCQQSTSGSTYVIGTNFMSTTDGTNSNTVEFKTTDASPRCTRVIFNCDPNTRGEPVAAATEQKPADLGCLATYTMAFTHACFCPGTTCSYGPSGSSSATPSVTATAVASETAAPQPSPPAPCTCTLESYLIVATASVGLTLVVVIVTHYALRAFKRSRQVQPQYMLLQNQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWK2</accession>
    <name>A0A0D2WWK2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343885.2">
        <property type="nucleotide sequence ID" value="XM_004343835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWK2"/>
    <dbReference type="STRING" id="595528.A0A0D2WWK2"/>
    <dbReference type="InParanoid" id="A0A0D2WWK2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="414" mass="44515" checksum="8F6F8C6542214FDA" modified="2015-04-29" version="1">MQTKRIMANAPSVKLVAPSLNNTSMLSMNTPSFASFALNNMADGAQTPELAKWLNDHSLNSEDILNVSVLPENTANNTNTAAMSSLLKSAVVTPHPHQQTAALMMHFTAKTSALSPPKTAAYDHHSSDSEESVATSSNSSTTNQRRRRAQQDDNDELAAQSKRVRVQVSGTAAGNDDDDNDNDNEADSADDTDSASSVFEDAQEGFVSLMAANGIKASATAFNPAMMNHISAAQVSFCPAPITAGTVPFYSPPSSECDLGELPSLNAVLSQANSALASSASTISGVIAGDSHSYIAYSSPQEYDNEPMAPRKRRRPATTEEERQSRRRERNRVAAVVCRQRKQRNEADLKDRVGMLTRDNAQLLSSATQLRQTIIVLKNALLRHHRTCTDPEMELAISSLDVATPASNVPLIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWM5</accession>
    <name>A0A0D2WWM5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWM5"/>
    <dbReference type="STRING" id="595528.A0A0D2WWM5"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWM5"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF1">
        <property type="entry name" value="NEPHROCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254843" description="LRRNT domain-containing protein" evidence="11">
        <location>
            <begin position="39"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="776" mass="81233" checksum="99602C4BBFB5A067" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWW1</accession>
    <name>A0A0D2WWW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343244.1">
        <property type="nucleotide sequence ID" value="XM_004343194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWW1"/>
    <dbReference type="InParanoid" id="A0A0D2WWW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="792" mass="82841" checksum="3DA7D2429609E500" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXD0</accession>
    <name>A0A0D2WXD0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXD0"/>
    <dbReference type="STRING" id="595528.A0A0D2WXD0"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXD0"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXD0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF84">
        <property type="entry name" value="REPEAT TRANSMEMBRANE PROTEIN KINASE, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="346"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="614" mass="66679" checksum="85FAA37434D3752C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXD3</accession>
    <name>A0A0D2WXD3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343003.1">
        <property type="nucleotide sequence ID" value="XM_004342953.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXD3"/>
    <dbReference type="STRING" id="595528.A0A0D2WXD3"/>
    <dbReference type="eggNOG" id="KOG0248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXD3"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="497"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="814"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125695" checksum="2E95CD868A1CC0DB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYS8</accession>
    <name>A0A0D2WYS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYS8"/>
    <dbReference type="STRING" id="595528.A0A0D2WYS8"/>
    <dbReference type="InParanoid" id="A0A0D2WYS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266671" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="193"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE98208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="798" mass="81144" checksum="A4F5BE1E73795524" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X040</accession>
    <name>A0A0D2X040_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamideisomerase</fullName>
            <ecNumber evidence="3">5.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X040"/>
    <dbReference type="FunCoup" id="A0A0D2X040">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X040"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X040"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X040"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="259" mass="28083" checksum="812799865F5C94E2" modified="2015-04-29" version="1">MTEKQSVSRFRPCIDLHDGKVKQIVGGTLAASGVTTAELKTNFVAEHDAGYYAELYRTDGLLGAHVIKLGPNNDAAARQALMAWPGKLQVGGGITDANAREWIEAGAAQVIVTSWLFPNAQLAIDRVKSLSQAIGRDKLVIDLSCRRRQHPDTGAMTWFVAMDKWQTITSTEITPALLQELAQYCVEFLVHAADVEGLCQGIDEDLVRLLGASSPIPCTYAGGGKHISDLELVDRLSNGRVDLTFGSDCVAWNQRHSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X065</accession>
    <name>A0A0D2X065_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X065"/>
    <dbReference type="InParanoid" id="A0A0D2X065"/>
    <dbReference type="OrthoDB" id="9983043at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X065"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36338" checksum="3DC5D1B7DD0E58DF" modified="2015-04-29" version="1">MANYTPSAAILAMIPQTPPLASQDSDVNLFVRSALFQFVLEFGEAFNLSDDVRFRALELFNAFMDSVVNEVIELSTKQLEQSSSSSSAPPPGSSMPDRTTRQTNGSMGARVEPATGLTLDAQNLLQTHLMSARLRIITCISLATKLDSSARQLSIYEYAMLLEFQYTPQQIIQSELDVCCRLKFELRVPTVYNHMQDLCQQVVQFIHDTELVPVTFPPDFEEQLREESVRVLEESYMVLKATGSQSDTTYLQLFERRRAHAASVVLATGIHLIDEEHGDIRAAFVDFLAAVSSQVIDMSLTLCERVVTTHVEDEPDTGRTLLSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0M3</accession>
    <name>A0A0D2X0M3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxisomal membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365677.1">
        <property type="nucleotide sequence ID" value="XM_004365620.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0M3"/>
    <dbReference type="STRING" id="595528.A0A0D2X0M3"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0M3"/>
    <dbReference type="OMA" id="QHSVFAY"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0M3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="180" mass="20630" checksum="9DB07F30057CCBE3" modified="2015-04-29" version="1">MANNALLQAYLGALQRRPMLTKAVSASVIASLGNVLSQRIRNTPRVDYRSIASYAIFGLCFNGPITHKFYEILERFSTPGKPPSRSRQFIKLLGERFIFAPLFTLLFFIVVSLLEGKTWEETMHKVRTLYPGAVKMNLIVWTPAQFINLNYIPLQYRVLFANAVAFLWTIYLSKRMAPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0X5</accession>
    <name>A0A0D2X0X5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349760.2">
        <property type="nucleotide sequence ID" value="XM_004349710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0X5"/>
    <dbReference type="FunCoup" id="A0A0D2X0X5">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0X5"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0X5"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0X5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="297"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="595"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="947" mass="104021" checksum="2553D7AA0411C688" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X192</accession>
    <name>A0A0D2X192_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_001720</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364588.1">
        <property type="nucleotide sequence ID" value="XM_004364531.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X192">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X192"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X192"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X192"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="471"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="719"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1202"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1358"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1453"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1501"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1541"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE90404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1628" mass="178108" checksum="38887F29C74777C6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X215</accession>
    <name>A0A0D2X215_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363698.2">
        <property type="nucleotide sequence ID" value="XM_004363641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X215"/>
    <dbReference type="InParanoid" id="A0A0D2X215"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X215"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="44531" checksum="9FC01125998DFE38" modified="2015-04-29" version="1">MSSQERATPSSSSSSHSRIATPRSSTAARQAPFPTTSRSPHHSSSSTPAAAAPAASPAASSNINATGSARRPAAAAAAAAASTAQSSPIEEHFPRVQSLSNKTWHAFRVSPLYRMQTDAQSLRLYSRSLTAALVARRDRSHAALIDASNSNGSSSSSTAANGSAEIGAANIGLLPGIDRLPGVPRALGIVVAAPPRAVPSSLRGRQLQAEETAKQKAAGAAPESRLLAVLGNFRRARPAGSDAAGGNGGTVQDDADNKDFTFLPLLLVKSTPQLTQEVCGWLESTFDCKVTHLAFPPVELAWMAFMWSAQNVSYTAAAAAAAAAAAAAAAAANESSPALCDALNRSKAAQREAGDASSMFLAVDTSQAFMKALEEHFFSISGIRLSALQLTRIGTGTAYVGAEGRVKLFSQNPVVIGNVLNQLSELASLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X262</accession>
    <name>A0A0D2X262_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270272.1">
        <property type="nucleotide sequence ID" value="XM_011271970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X262"/>
    <dbReference type="FunCoup" id="A0A0D2X262">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X262"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X262"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X262"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="115"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="379" mass="42683" checksum="48E9A2B93746B4CD" modified="2015-04-29" version="1">MFGRRATKDSGAGTEQADENIAASKAKANAAARRARADAGKPVFTATASMDDETELGERSHKHQDRYGFRTDDPSSPLKWDAIQEYLSHQYAAILMHRSSRWMHIYVRDLPVLKGVPSDWRAPVWLDICGATVFRQQNPNLYAQLLVDSPAKANPILTALFPRTFTLNRPPMDPMPSIQKLRRVLVAYAAYDPEIGYCQGLNFIAAMLLLVLRDESDAFYALTQIIGKDAHLAPRYHVPSMAPLLTDLAVAEELVRLRYPEIHDLFVRNGVTLSLIATKWFICMFIDSTPPETTMRIWDSFLYEGSKVLFRVTLALIQIHHQELLRAKDMASFFNGVKNSSLAAVDCHHLMDVAFNKLGTFRRSLINALREELAAPSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2A6</accession>
    <name>A0A0D2X2A6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2A6"/>
    <dbReference type="FunCoup" id="A0A0D2X2A6">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2A6"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2A6"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2A6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266754" description="Glycylpeptide N-tetradecanoyltransferase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="10">
        <location>
            <begin position="309"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="497" mass="56055" checksum="FE62A35B58B4F50D" modified="2015-04-29" version="1">MLGMSFYLFFFLLSMSDQKEELPTVGSVPHLASTSTGASTSASSSSSSSTASSSSSDAVKAAVADAVAQAAEHPPMSAEQAATQPSSLANLSQDQLAAMIQLLNLDGKGKAKEQDKEHKFWKTQPVLQYDQSSDAVEPIEPDNANIRQEPYPIPADFEWVTLDLLKEDQLSELYNLLNENYVEDDDNMFRFDYSREFLRWALLPPGWKPIWHAGVRASKSRKLVAFISAIPATLKVKDRVQPLVEINFLCVHKKLRTKRLAPVLIKEITRRVHLQGLFQAVYTAGVVLPKPFSTCRYWHRSLNPKKLIDIGFSHLGRNMTLARTIKRYKVAEQPTTAGLRLMKAADVPSAFRVLSTYLERFAIKTVYTEEEFVHWFLPRNNVISTYVVENSKHEITDLVCWYTLPSTIVNNPNYSNLKAAYSYYTVANTVPFEQLLSDALILAKNEEFDVFNALDLMQNAPVFENLKFGIGDGQLRYYFYNLKCPEVQPSELALVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2B1</accession>
    <name>A0A0D2X2B1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364092.2">
        <property type="nucleotide sequence ID" value="XM_004364035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2B1"/>
    <dbReference type="STRING" id="595528.A0A0D2X2B1"/>
    <dbReference type="eggNOG" id="ENOG502QVVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2B1"/>
    <dbReference type="OrthoDB" id="2019614at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2B1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029131">
        <property type="entry name" value="HAUS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14817">
        <property type="entry name" value="HAUS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="801" mass="88466" checksum="C1326F9573AD7C1B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2J1</accession>
    <name>A0A0D2X2J1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363297.1">
        <property type="nucleotide sequence ID" value="XM_004363240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2J1"/>
    <dbReference type="STRING" id="595528.A0A0D2X2J1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2J1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2J1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21181" checksum="39085BC524A2FB6F" modified="2015-04-29" version="1">MWAAVVQNAQAVWPETQPLSLDSISRHPCEQRFGSAGLLFEHLREVHVGLRLDKTFQGQCQWANCSRADQQFGKPYDLVSHIQVHVNVRPFECICGARSKRQSDLRKHLEGCCQGTDFKWTKATSGLFLARKGFSDDAITRILQLVQDPEDILRVTDAQLLEVQMDAQTCRLVLDGTPVEFRNNTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Y3</accession>
    <name>A0A0D2X2Y3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347985.2">
        <property type="nucleotide sequence ID" value="XM_004347935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Y3"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Y3"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Y3"/>
    <dbReference type="OrthoDB" id="442451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Y3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="750"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1080" mass="115452" checksum="A71B253DE4BF4563" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3M3</accession>
    <name>A0A0D2X3M3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346872.1">
        <property type="nucleotide sequence ID" value="XM_004346822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3M3"/>
    <dbReference type="STRING" id="595528.A0A0D2X3M3"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3M3"/>
    <dbReference type="OMA" id="CLKARIH"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3M3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="235"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="51370" checksum="75EEA12F43E05B42" modified="2015-04-29" version="1">MQPLQIEQALAIIQGATSLSQLSSGLRSLLDFEHQKLAASLKMQRQQQQQQQRQEQRQEQQQQQQSLMQLAEPSLLLVNTALASLDPAVHTLGFIWLLRVKFTSVEAARQDPSFIPLLHAVLSRGDEAQLQLAGYLLYVICDVVALYAHETMQFERTIAILVLAIQKAAKPGLLTIMHVHLSQLAQLAQCFHVAHVFDADIVEISPTSTSLKIVHVLSYYYYVGMIYCGLKQWRRAMHFFGMAVSAPANTTSLIAVESYRKYVLASLLHSGKVEDLPKYTSSNVVRTAKQISVPYVEFAALFEKLSLAEAALLVASQSSVFLEHTNLGLVKQCMASLTRRIVQRLTQTFITLSLTDIATHARLSSAKEAEHLLVQMIESGEIHAQISQRDGMVAFKDDPNRFESAETVAAVDAKIRRSIQLHEHLSRLTADILTSSSYIKKTEFGAQGSAQHDLDDMEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3W1</accession>
    <name>A0A0D2X3W1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346202.1">
        <property type="nucleotide sequence ID" value="XM_004346152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3W1"/>
    <dbReference type="STRING" id="595528.A0A0D2X3W1"/>
    <dbReference type="InParanoid" id="A0A0D2X3W1"/>
    <dbReference type="OMA" id="NSREDTR"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="360"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="673" mass="71939" checksum="94519DDAFC4BB0C9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4D7</accession>
    <name>A0A0D2X4D7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_006282</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4D7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4D7"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4D7"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4D7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270416" evidence="17">
        <location>
            <begin position="31"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="729"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="539"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="589"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE95879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1018" mass="107857" checksum="84EF40188C5E09E9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H0</accession>
    <name>A0A0D2X4H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345167.1">
        <property type="nucleotide sequence ID" value="XM_004345117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H0"/>
    <dbReference type="STRING" id="595528.A0A0D2X4H0"/>
    <dbReference type="eggNOG" id="ENOG502QT04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4H0"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4H0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF0">
        <property type="entry name" value="FUMARATE HYDRATASE CLASS I, AEROBIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="12">
        <location>
            <begin position="90"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="13">
        <location>
            <begin position="372"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="582" mass="62938" checksum="03B7CE5FCAFFE39B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4K1</accession>
    <name>A0A0D2X4K1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345306.1">
        <property type="nucleotide sequence ID" value="XM_004345256.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4K1"/>
    <dbReference type="eggNOG" id="KOG4381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4K1"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17671">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053015">
        <property type="entry name" value="PH_domain-containing_M2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="89"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1493" mass="157018" checksum="FF093CFE5D258A11" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4W2</accession>
    <name>A0A0D2X4W2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007026</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343750.1">
        <property type="nucleotide sequence ID" value="XM_004343700.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4W2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4W2"/>
    <dbReference type="eggNOG" id="KOG0790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4W2"/>
    <dbReference type="OMA" id="ESMAYKQ"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4W2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000012">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="235"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="417"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="615" mass="69059" checksum="26FC11D1850211D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X513</accession>
    <name>A0A0D2X513_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343371.2">
        <property type="nucleotide sequence ID" value="XM_004343321.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X513"/>
    <dbReference type="eggNOG" id="ENOG502QT3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X513"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X513"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF38">
        <property type="entry name" value="KINETOPLAST-ASSOCIATED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1253"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="139983" checksum="5188CC7E7A07B540" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X561</accession>
    <name>A0A0D2X561_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343562.1">
        <property type="nucleotide sequence ID" value="XM_004343512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X561"/>
    <dbReference type="STRING" id="595528.A0A0D2X561"/>
    <dbReference type="eggNOG" id="KOG3795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X561"/>
    <dbReference type="OMA" id="VNAWGLN"/>
    <dbReference type="OrthoDB" id="3173at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X561"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="13">
        <location>
            <begin position="55"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="304" mass="34795" checksum="7361B03EFD93972B" modified="2015-04-29" version="1">MSESTSTSTSVAAAPELEKFPDWSPFQDLKIASHEPLYAAERAGRVACPKCQHKRLFFCFDCRIPLAERTLPNVELPLRLDIIKHKGEANSKSTAIHAAIIAPHQTAIYEHPAVPEDIDPTRTVLVFPSKDALTFEDLPDDFVEKGGRVMFIDSTWNQAHGVNSNPALAGIPRIKFTSETSRFWRHQKDKPATYLATIEAIHHFFRLLHERFTRTPYDGRYDNLLYFFSRQYHRIQQHYEGADSKKNWRLEAMNFFQLPEDKSKRTASEAEASENDEEETRRTRPRLEEDKTADDATTSATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X588</accession>
    <name>A0A0D2X588_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U4/U6 small nuclear ribonucleoprotein Prp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343113.1">
        <property type="nucleotide sequence ID" value="XM_004343063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X588"/>
    <dbReference type="STRING" id="595528.A0A0D2X588"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X588"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X588"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000443">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="495" mass="54338" checksum="F6786E878B7577BC" modified="2015-04-29" version="1">MSAHLLKPNATFTAAQHDEIREDFERKIRAKQIVVPTNDEHVRKRLRQLGEPITLFGEGKAERRDRLRELLSRQASSAAATGAGAAGEDQGEEAEDGSESDEDEDEGEDDEGEDKAANADAAAATTAPSGYNQKEVWYHEGPEELEAARRFIAAYSLVAARERLKRQRIQVARPEPVKAAAMNESLKFARELTNYGSQIGDDRPLSSCTFSPDGKTLVTGAFTGLLKLWSSPECKLIRTLRAHAERVSSIAFHPQSGKSLDASAANFASCGVDGTVKLWSMTSETSVAAIDGHEARVSRLAYHPSGRFLASTCFDHSWRLYDFAAQKEILFQEGHSKPVYGIAFHPDGSLAGTSGMDAFGRIWDLRTGRNVMLLNGHVNALLGIDFSLDGYTVATSSEDHTIKIWDLRKQACAYTIPAHNNLVSLVKFDPVNGHYLVSAGYDNLIKVWAAGTWANIKTLSGHENKIMSLDISSDGTFFASASYDRTFKLWSNDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5K6</accession>
    <name>A0A0D2X5K6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mediator complex subunit 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_010173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5K6"/>
    <dbReference type="STRING" id="595528.A0A0D2X5K6"/>
    <dbReference type="InParanoid" id="A0A0D2X5K6"/>
    <dbReference type="OrthoDB" id="10018574at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5K6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43816" checksum="21D971B579AF6310" modified="2015-04-29" version="1">MVVFYHNKLQHPSIEIQTQNLYIETTENAHALFIIQSLFCWCLLQASLETCLYCSQMRDETIVYDVAWSALQPQLLHASLQPVHSISTPTTGSSGSAGSRRPDARQLRQELTAQPAYQCIDWSARNLIAFATCSRVLPLATTLQSVAGTGAGASLPTGSAGVAGGPPASMNTVTAGPSSAANQANPNPTQSTSSAAGTAPSVQEASGEMRLHTIHIMDPNTPWAMCSLAQEHHTRPIKTLKWSGSGFQLISIDDGGTLCLWRMRSHLANEWYCEHTQSYGTDESVVAAVWLENGLVHKPPTVVDDMSDASLARSYSEKFSHSFSTVPLGAPSTSWLLLTSSGKVPCCSSLLPSFSLCIPMQMLTFSPPPTFRSLDEPTAFAAIPNITHQLVQFQHEHCAFATAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P6</accession>
    <name>A0A0D2X5P6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270885.1">
        <property type="nucleotide sequence ID" value="XM_011272583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5P6"/>
    <dbReference type="STRING" id="595528.A0A0D2X5P6"/>
    <dbReference type="InParanoid" id="A0A0D2X5P6"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="547"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="726"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE98174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="822" mass="89914" checksum="6FD047F1B71B705C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1D9</accession>
    <name>A0A0D2U1D9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365451.1">
        <property type="nucleotide sequence ID" value="XM_004365394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1D9"/>
    <dbReference type="eggNOG" id="ENOG502SSV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1D9"/>
    <dbReference type="OMA" id="CCPTCFD"/>
    <dbReference type="OrthoDB" id="525285at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="178" mass="19321" checksum="C4D81F3ED4EA3C90" modified="2015-04-29" version="1">MDPIFQATRTPNLNALMYMAPASQRYKTQLYLQACCTLNLCMCAAVDDLLRRTYVAVYENKIEYNYPWCNCWCLCDQVGVVYFDRTLTAAVTPAGCCTPAFTHCSCCPTCFDICGEAIVLHGATCCDKNQTIIGGICCCRAWTLLPGLDNAGNLAAAILSNRAIALAKLQAGGQVVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2G5</accession>
    <name>A0A0D2U2G5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_000878</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365749.2">
        <property type="nucleotide sequence ID" value="XM_004365692.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U2G5"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2G5"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1857"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE89401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1907" mass="203362" checksum="A23ABE06B35CBB36" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4A0</accession>
    <name>A0A0D2U4A0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Choline/ethanolaminephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4A0"/>
    <dbReference type="FunCoup" id="A0A0D2U4A0">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4A0"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4A0"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4A0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="459" mass="50838" checksum="9BD79E85DFD1908A" modified="2015-04-29" version="1">MKREIRPNLRSLASQISRSPCTTDPSGIKRTPTNALFFFFPRLRFSLRNGWKPSFSHLFPLCLFLFPKMSAPYLTPAHVKGMREHKYACSTNSYLDLHVMVHFWNWLVKLVPLWVAPNLITMVGLIVNVATSVILLSFVPTGQGEAPRWAYGACALGLFIYQSLDAIDGKQARRTNTSSPLGELFDHGCDSVSMAFLALAGGAAMSVGPTSTLLVLSLLFNFIFFCAHWQTYVRGTMIFGVVDVTEGQMAVILVHLLTFFFGSSWWLEETFGVPRNMLIIAVSSSGIILMFFRTFQTIAQHDPNKGTVANTSVVSPIIPCIILFVCTYISYHNSAIGLYQTHPVVFIFAFSVCFAKITNQMVIAHMSKMPFPLYDRVLLAPIALTANIYFFNSAVDELVALYVFVGVALFDLIWSSYFICNEMCVAFGIKCFTIPYPPSGAAAATSSGPVTRSASAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5I4</accession>
    <name>A0A0D2U5I4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364590.1">
        <property type="nucleotide sequence ID" value="XM_004364533.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5I4"/>
    <dbReference type="STRING" id="595528.A0A0D2U5I4"/>
    <dbReference type="eggNOG" id="KOG4716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5I4"/>
    <dbReference type="OMA" id="HPTCGEI"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="53970" checksum="B81D5EEB8558B1FC" modified="2015-04-29" version="1">MAETPSTTGYDYDLIVVGGGSGGLALSKQAAKLGKRVCVLDFVKPSPQGSTWGLGGTCVNVGCIPKKLMHQACLLGEAIEDAEKFGWEVEKANIKHDWSKLVMGVSDHIGGLNFAYRVSLRENNVTYLNAYGVFKDAHTIECTDKKRKVTTLTAEHFVLAVGGRPKYPDIPGARELGITSDDMFSLPYAPGKTLVVGASYVALECAGFLTGLGYDTTVMARSIFLRGFDQQCAEQIAAYMSEHGTKFLRRCVPLSLERIEPEADSATGRHRIRVTWEDGLANEPGSDVFDTVLFAIGREAVTSTIGLEALGLKANASGKVDAPLEQTSVPNVFAIGDVINGRPELTPVAIQAGRLLAKRLYGGATTQMDYANIPTTVFTPLEYGCIGMAEEDAIALYKEENIEVFHQYFQPLEWTVAHRPASTCYCKLICNKLDNMRVIGLHILGPNAGEITQGYGVAFRLGATKDDFDMTVGIHPTCSENFTTLDITRASGLDPGAKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U701</accession>
    <name>A0A0D2U701_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein 1</fullName>
            <ecNumber evidence="6">4.1.99.22</ecNumber>
            <ecNumber evidence="7">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_002162</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="6"/>
    <dbReference type="EC" id="4.6.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348912.2">
        <property type="nucleotide sequence ID" value="XM_004348862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U701"/>
    <dbReference type="STRING" id="595528.A0A0D2U701"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U701"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U701"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000117">
        <property type="entry name" value="molybdenum cofactor biosynthesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001199">
        <property type="entry name" value="PRK00164.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="22">
        <location>
            <begin position="107"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE90936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="657" mass="71975" checksum="BFFBADCF0AD3E96A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7V4</accession>
    <name>A0A0D2U7V4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000754</name>
        <name evidence="13" type="ORF">CAOG_002343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365625.1">
        <property type="nucleotide sequence ID" value="XM_004365568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7V4"/>
    <dbReference type="FunCoup" id="A0A0D2U7V4">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U7V4"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7V4"/>
    <dbReference type="OrthoDB" id="10255923at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="11">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="11395" checksum="DF28C8DF55C0EC5C" modified="2015-04-29" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTIYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA23</accession>
    <name>A0A0D2UA23_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidylethanolamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA23"/>
    <dbReference type="FunCoup" id="A0A0D2UA23">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UA23"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UA23"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UA23"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="805" mass="89771" checksum="E2983D75E7E359F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBC5</accession>
    <name>A0A0D2UBC5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364176.2">
        <property type="nucleotide sequence ID" value="XM_004364119.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBC5"/>
    <dbReference type="STRING" id="595528.A0A0D2UBC5"/>
    <dbReference type="eggNOG" id="KOG2225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBC5"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="696" mass="76621" checksum="0C1B0D3D35841159" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBG8</accession>
    <name>A0A0D2UBG8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Epsilon-adaptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBG8"/>
    <dbReference type="STRING" id="595528.A0A0D2UBG8"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBG8"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBG8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="55"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1245" mass="133666" checksum="829529B678953226" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDY9</accession>
    <name>A0A0D2UDY9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270385.1">
        <property type="nucleotide sequence ID" value="XM_011272083.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UDY9">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDY9"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDY9"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDY9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="494"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1737"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1999"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2130"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="567"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="729"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="681"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1750"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1775"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1789"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1843"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1866"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1889"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1917"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1943"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1999"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2015"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2130"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2147"/>
            <end position="2160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2160" mass="235620" checksum="75E318AFB5D43940" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEK3</accession>
    <name>A0A0D2UEK3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348145.1">
        <property type="nucleotide sequence ID" value="XM_004348095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEK3"/>
    <dbReference type="InParanoid" id="A0A0D2UEK3"/>
    <dbReference type="OrthoDB" id="18100at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253360" evidence="2">
        <location>
            <begin position="24"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="901" mass="97185" checksum="AAB1BB5AD2F37FDE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF04</accession>
    <name>A0A0D2UF04_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF04"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF04"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354317" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="25"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="609" mass="66444" checksum="8E723F5F4945E452" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH90</accession>
    <name>A0A0D2UH90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346801.2">
        <property type="nucleotide sequence ID" value="XM_004346751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH90"/>
    <dbReference type="STRING" id="595528.A0A0D2UH90"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UH90"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH90"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1600.10:FF:000013">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="302"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="773" mass="82969" checksum="A8EDEDBBB875ED80" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ09</accession>
    <name>A0A0D2UQ09_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343422.2">
        <property type="nucleotide sequence ID" value="XM_004343372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ09"/>
    <dbReference type="FunCoup" id="A0A0D2UQ09">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQ09"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQ09"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQ09"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="472"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="738" mass="79045" checksum="76ED77B59517CF0D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ82</accession>
    <name>A0A0D2UQ82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ82"/>
    <dbReference type="InParanoid" id="A0A0D2UQ82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="102" mass="11489" checksum="CD1CF5602FC237E5" modified="2015-04-29" version="1">MVQFLYRLQRPMLSSGGAFFFLHFRLVLKLHTQTYSSKHLATSEKKAAASAVDLANLRFIRSQPPLVRVPPLQLENTRTVFSIILASFPNQGSIPSLVKPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US11</accession>
    <name>A0A0D2US11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_007859</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342944.2">
        <property type="nucleotide sequence ID" value="XM_004342894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US11"/>
    <dbReference type="FunCoup" id="A0A0D2US11">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2US11"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2US11"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2US11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="81"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="232"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="484"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="585"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="714"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE97756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132121" checksum="1AE20B9087B56639" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG06</accession>
    <name>A0A0D2VG06_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365188.1">
        <property type="nucleotide sequence ID" value="XM_004365131.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG06"/>
    <dbReference type="STRING" id="595528.A0A0D2VG06"/>
    <dbReference type="eggNOG" id="ENOG502S8NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG06"/>
    <dbReference type="OMA" id="LEMFLWE"/>
    <dbReference type="OrthoDB" id="2147008at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="BLL0914 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446:SF1">
        <property type="entry name" value="BLL0914 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="115" mass="12108" checksum="407FCA627C4D2839" modified="2015-04-29" version="1">MLGSLLALLVGALHVYFLVLEMFLWTKPYGRKVFRLDPAFAEKSATLAANQGLYNGFLAAGLCYGVVTGSTEFILFFLVCVIIAGAYGGATVKPIIYYVQAAPGLAAAAAVLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGN5</accession>
    <name>A0A0D2VGN5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365467.2">
        <property type="nucleotide sequence ID" value="XM_004365410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGN5"/>
    <dbReference type="FunCoup" id="A0A0D2VGN5">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGN5"/>
    <dbReference type="InParanoid" id="A0A0D2VGN5"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGN5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="176" mass="19340" checksum="DED56916EEBD2468" modified="2015-04-29" version="1">MAQAPATSSNGKPIPSQEEMSLLAMPLGQLQTFAKQMDEEVRFLIQSLSQLHQAVKRFEESRDSLAQLGDAKEGSDLLVPLTSSLYVPGTLANAGKVMVDIGADYYVERSVKDASAFFSRRIAFLMDNIEKLQKTIGTKRANLNSLQDIIDRKTQYQQQQMQQAAAAQGKGVRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI79</accession>
    <name>A0A0D2VI79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4442 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270038.1">
        <property type="nucleotide sequence ID" value="XM_011271736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI79"/>
    <dbReference type="eggNOG" id="ENOG502S7PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI79"/>
    <dbReference type="OrthoDB" id="10255641at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23289" checksum="E42B284CEA8BA7F2" modified="2015-04-29" version="1">MTVTDVAATAVLYPLFLVFGVLQFIVALVINTPALVAWALSGKAKRRFLESLWGAVHKQPLGRELISTLMGILSTYTGSVSPFIAQVDATETLVQLTERPWLRNPFTSIHALAIANAAELASGLLATRATEHFGGRVIVTNISVAYDRKARGVISCHAQLTPEQVRQVESMASSAQAGKPVDESLVIQVNVLDSKKEIVSRLQATWVVRVSGGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ04</accession>
    <name>A0A0D2VJ04_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349883.1">
        <property type="nucleotide sequence ID" value="XM_004349833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ04"/>
    <dbReference type="STRING" id="595528.A0A0D2VJ04"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJ04"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJ04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="550"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="836"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="892" mass="94348" checksum="FDB6604A762DAF62" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJM3</accession>
    <name>A0A0D2VJM3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJM3"/>
    <dbReference type="STRING" id="595528.A0A0D2VJM3"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJM3"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="695"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="880"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="987" mass="108558" checksum="4E621087914E3778" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK00</accession>
    <name>A0A0D2VK00_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK00"/>
    <dbReference type="FunCoup" id="A0A0D2VK00">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VK00"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VK00"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="410" mass="45452" checksum="8E4A2B2577DD5D52" modified="2015-04-29" version="1">MSVGELNGDGLRVHRLLQWVSTGFPLPIDVYTLSCFWRATICNNSVAIIIIPAVLRFQQKMSHTTTIPVIDIGAFVDAAKRADSDATAASLGAAFRDVGFAYITGHGVPSAVIQKAFSHAKRLFELPMDAKEALSMTGANAHTHRGYSGFGDEVLNEETKDWKEAFDIGYDLPPSDPDVAAGVPLHGPNVWPSHESAPELATFKHDLELYFSHMERVGRSLLVGFEKHFGLADGYFEPFFQRPLVLMRLLHYPPLPEEMLNSTTPGRDIVTCGEHSDYGGLTLLAVDAPGLQVKSTNGEWIAAPPMGNDALIVNLGDMMQRWTNDVLKATPHRVVNVNPLAHRYSIPFFFEPNFHSIVRCLEPCLRLSGTTVPKYPDTQYGPYLLSRYDATFNHRKDDESNPTNARPGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK43</accession>
    <name>A0A0D2VK43_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364575.1">
        <property type="nucleotide sequence ID" value="XM_004364518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK43"/>
    <dbReference type="InParanoid" id="A0A0D2VK43"/>
    <dbReference type="OMA" id="VYERCEF"/>
    <dbReference type="OrthoDB" id="17373at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK43"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253662" evidence="3">
        <location>
            <begin position="27"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="197" mass="21299" checksum="B32B0B922AF7A240" modified="2015-04-29" version="1">MVRKSASSLLLLVGCIALLVARPAFALSKCAVVAHLHNIGTFSAKDIAKLTCIAQHASGFDPSLQDRSKGPQTRWGLFGMAESQWCSTQFGASTGNNVRDVIPVDTPGNQCQVACNDLMIASQSIRCARIAIGKQGFSAFPEYAANKADCDNYTVDECSKTRKPHAAPRQEQVFVGSHQMPRQGDKVQMPSSERDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VML5</accession>
    <name>A0A0D2VML5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349302.1">
        <property type="nucleotide sequence ID" value="XM_004349252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VML5"/>
    <dbReference type="eggNOG" id="ENOG502SDK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VML5"/>
    <dbReference type="OrthoDB" id="5537783at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VML5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16862" checksum="73EEF3F309F094FE" modified="2015-04-29" version="1">MSFVDSGKLGFYAGGLLTTAAFYGLGAFWRRHSSITPSALVKVLNSQLQKNPRVIEKLGADLRPAKFTAYAYSGGLRYGKDVEGWFPVAYSTPVLELMYQLNGNKSSAMVSTKVSKKNGQLVYHSLALDTNLGETLLIYGTQADVVYKGIVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMT4</accession>
    <name>A0A0D2VMT4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349386.1">
        <property type="nucleotide sequence ID" value="XM_004349336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMT4"/>
    <dbReference type="STRING" id="595528.A0A0D2VMT4"/>
    <dbReference type="eggNOG" id="KOG4322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMT4"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="302"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="978" mass="107080" checksum="EE1510D03FCD4F06" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQG3</accession>
    <name>A0A0D2VQG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQG3"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246">
        <property type="entry name" value="MUCIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47246:SF1">
        <property type="entry name" value="MUCIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269458" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1886"/>
            <end position="1910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1928" mass="183329" checksum="DD1A57319FCFA726" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU21</accession>
    <name>A0A0D2VU21_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270549.1">
        <property type="nucleotide sequence ID" value="XM_011272247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU21"/>
    <dbReference type="FunCoup" id="A0A0D2VU21">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VU21"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU21"/>
    <dbReference type="OMA" id="GACPYFW"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254501" evidence="5">
        <location>
            <begin position="25"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="382"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="63817" checksum="3D3117E800618551" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV03</accession>
    <name>A0A0D2VV03_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV03"/>
    <dbReference type="InParanoid" id="A0A0D2VV03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="18477" checksum="9CB0ADF40BECA605" modified="2015-04-29" version="1">MRFFPRVTPTLQNQSSTTTTTTFSIPKLIVSHCVWLTTIRLQESGRKERDLPQHQRSNPRTNQRFGVSAPIAGFPGSACCPACCSLLPLRRSFSCLIEAIERFPKWGRGQESTVCIFCGSLCGSVLCRAQPHFVFVCSCFSFVIPSIIACYQRRDQMDSLSFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVI9</accession>
    <name>A0A0D2VVI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345540.1">
        <property type="nucleotide sequence ID" value="XM_004345490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVI9"/>
    <dbReference type="STRING" id="595528.A0A0D2VVI9"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVI9"/>
    <dbReference type="OMA" id="YHDYRTI"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="35615" checksum="F11AA6484A0DD166" modified="2015-04-29" version="1">MASFGTASVDDLPPMHNVVTLNSSDTLQAATHTLIKNRVLSAPVWDAATHSFLRTSSSDLFDVLCAIVTHVKEADLNVGNYASLVDDHELLSKSSIKDLIDFAARNPFCTVAKGTLLNDIMPLLAGVQSNAWVRRVIVQDGPSDTAPSRSQIAAIVSQNKLIEYASRHKKAWADMKSTTVQTAFLGAAFTTPITVSSDARVYDAFKLLRDHNISGIAVVDHSGRVIGSLSSRDVKGLEDETNLQLDLTRLMAPVRSFIAYISQLTITDAEKHPAISVRPEDTFERVVDMFASSKVHRLFIIDSNSHAIGVISRVDLLRYLATGEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW62</accession>
    <name>A0A0D2VW62_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345762.1">
        <property type="nucleotide sequence ID" value="XM_004345712.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW62"/>
    <dbReference type="InParanoid" id="A0A0D2VW62"/>
    <dbReference type="OMA" id="DYIGESH"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18354" checksum="44837D653B10D06D" modified="2015-04-29" version="1">MSCPKDYIGESHKKIERSGSLKKQGSVAGETDAAHKFSWGTLNVIETHTPGAPMGEKARRELTAKMNAAANLRIKSRTGNRRTDERNDGKMVQHFLNKTPIRSRQVVARAEQAFSGAKTLPNPKYATALGKMKVHNAATGRSHTLKNHHQHKPRAQTKLTPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY86</accession>
    <name>A0A0D2VY86_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343666.1">
        <property type="nucleotide sequence ID" value="XM_004343616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY86"/>
    <dbReference type="STRING" id="595528.A0A0D2VY86"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VY86"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="719" mass="77442" checksum="F29965CD5DE27D55" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYC4</accession>
    <name>A0A0D2VYC4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343712.1">
        <property type="nucleotide sequence ID" value="XM_004343662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYC4"/>
    <dbReference type="InParanoid" id="A0A0D2VYC4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="325" mass="35683" checksum="10029F29ED10E23F" modified="2015-04-29" version="1">MQQRQQQQQQQQEFWPFAVLQCEMLEFFTKASETLQDGAGNRVFQTSLPSCSITELLELLATVPMGLQSERQGSLGTATQRCLPNQLLLQHIHCGTLHPQQESRSLCTSTKDNVHVRIHTRQRRDPLCGLRAPVGRIRAWQQHLASSITSAALLPCSTIVPTLKMLSLTAWQADPLPTGALPSCSPPASAPHNFAGGKLRIHINRAALPTPRHLPPTLRVSRPDPCACPSFDGVLAPLFPVARTAVASSSSLSSSSQSSKLLNLSKPRIDAFLIDVKHLPLPFDDTTALQLLLSESCCSFLVEHNANSAQRLKTELPRTQFRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYT8</accession>
    <name>A0A0D2VYT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343889.1">
        <property type="nucleotide sequence ID" value="XM_004343839.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYT8"/>
    <dbReference type="STRING" id="595528.A0A0D2VYT8"/>
    <dbReference type="InParanoid" id="A0A0D2VYT8"/>
    <dbReference type="OrthoDB" id="4445at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="106362" checksum="116AEEE608DA74F5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZJ2</accession>
    <name>A0A0D2VZJ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343587.1">
        <property type="nucleotide sequence ID" value="XM_004343537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZJ2"/>
    <dbReference type="InParanoid" id="A0A0D2VZJ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11880" checksum="645835AA314898C7" modified="2015-04-29" version="1">MERYTKALVSGAAVIYFGYWCMTRTTPSHDELLGRLPAEERRRLARSHDDRQAINQELMNQIQKNAASTKPVWQVDIEPSSIPLPPTPAPTTPASPVSPTVKPTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1R7</accession>
    <name>A0A0D2W1R7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342439.1">
        <property type="nucleotide sequence ID" value="XM_004342390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1R7"/>
    <dbReference type="InParanoid" id="A0A0D2W1R7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="210" mass="21810" checksum="9E8489F0530222A1" modified="2015-04-29" version="1">MSSAITITAVAAPTSTNTAANTAPFCATCRGPCRFNTRFNATTTFPSTIWPGAVAATATATPAAAANVTTGAPIATTPAKVTKAKARRPVQAVERTIMTRAFSRKQQIAMKQQLQQPQRAAVAVAAAPSSPSAMRRTHTMQNTIADSLAVLAAHPELAMAIAALARNSNSNSKAGRRSQPADTLASPSRTLRSSAKFGRQLRPRVLAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WG89</accession>
    <name>A0A0D2WG89_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269953.1">
        <property type="nucleotide sequence ID" value="XM_011271651.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WG89"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WG89"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="80"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1330" mass="145153" checksum="AF1D5BBD302F7EB5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH40</accession>
    <name>A0A0D2WH40_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH40"/>
    <dbReference type="STRING" id="595528.A0A0D2WH40"/>
    <dbReference type="InParanoid" id="A0A0D2WH40"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH40"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="566" mass="61775" checksum="D2D18A190CF051D9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI20</accession>
    <name>A0A0D2WI20_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365759.2">
        <property type="nucleotide sequence ID" value="XM_004365702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI20"/>
    <dbReference type="eggNOG" id="ENOG502SNM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI20"/>
    <dbReference type="OrthoDB" id="42069at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="56604" checksum="3A2B72D637321F3A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI73</accession>
    <name>A0A0D2WI73_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365847.1">
        <property type="nucleotide sequence ID" value="XM_004365790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI73"/>
    <dbReference type="InParanoid" id="A0A0D2WI73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="226" mass="25607" checksum="F02BA2BFD05865A8" modified="2015-04-29" version="1">MGQLTNNSASKLLLELFEELNLGLKFSNGQLLLVDYYTAHYNDFMSNVDQNMTELQRKSVNAESKKLQEYVATVGGARFVTDTVNILMGDPKVTDDPGDKPFYDRLNSNKIIDENGALWFMLPIKGGELVLVNGTGWTHRKRVRTDYMSHFANIDLPDDDFDRCTELRKFTSQWMCKNEAMTDFLLALGGMALFGYRDEQRFWIIVGKGAGVTYQSKGLKVTSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIT1</accession>
    <name>A0A0D2WIT1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365463.1">
        <property type="nucleotide sequence ID" value="XM_004365406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIT1"/>
    <dbReference type="InParanoid" id="A0A0D2WIT1"/>
    <dbReference type="OrthoDB" id="6161264at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37397:SF1">
        <property type="entry name" value="LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37397">
        <property type="entry name" value="SI:CH211-183D21.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269963" evidence="3">
        <location>
            <begin position="25"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="775" mass="80921" checksum="5D87B4955624AC7D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIU0</accession>
    <name>A0A0D2WIU0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008491</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270073.1">
        <property type="nucleotide sequence ID" value="XM_011271771.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIU0"/>
    <dbReference type="eggNOG" id="KOG1083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIU0"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIU0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19174">
        <property type="entry name" value="SET_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AWS" evidence="15">
        <location>
            <begin position="501"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="550"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="14">
        <location>
            <begin position="1226"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1444" mass="160194" checksum="CCE03735F9A9AA09" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJF3</accession>
    <name>A0A0D2WJF3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365825.1">
        <property type="nucleotide sequence ID" value="XM_004365768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJF3"/>
    <dbReference type="STRING" id="595528.A0A0D2WJF3"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJF3"/>
    <dbReference type="OMA" id="GPYWPAE"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJF3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="261" mass="28951" checksum="F20C4661A6C8D49A" modified="2015-04-29" version="1">MASYSHLFQGVAVTSKYAAFRPVYPAALYHELLEFMGTQKPGFAIDVACGSGQLTSMLASHFQQVLAFDVSEEQIKSAAAAPNINYTVGSADAIPAQTNTADVVTVAQAMHWFDLPKFYAEVDRVLKPGGTLAVIGYGNCKLANQEANKVIQQFYSGTLKPYWSDRRFWLDNEYADVKLPYEDRARWDGAIVLRYSLEGILGYLSSWSGYHTYLKQNPTLPDPLIAVKADLLRAYATSSTTDVEVDLTWPLFMLLGKKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJL7</accession>
    <name>A0A0D2WJL7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adaptor protein complex AP-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364486.1">
        <property type="nucleotide sequence ID" value="XM_004364429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJL7"/>
    <dbReference type="FunCoup" id="A0A0D2WJL7">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJL7"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJL7"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJL7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="48615" checksum="C37C1AAEC26726F9" modified="2015-04-29" version="1">MISGLFIYSHKGEVLISRVYRDDIRRNVSDVFRVNIIHSRHQVRSPVNIINRTSFFHIKHENVWLVVAAKENVNAMTVFAFLHKFIQVFVSYFGKFNDEAVKNNFILIYELLDEVLDFGYPQIVDSNALKAYITQEGLKIARTSTGAGAVTSQLTGTVSWRREGIKYRKNQMFIDVIESVNLLMSTDGKPLSAHVSGSIMIKCYLSGMPECKFGLNDKILLEKDGRSQTRARKGGAGIAIDDCTFHQCVKLGKFEADRSISFIPPDGEFELMKYRTTDNIALPFKVIPLVKESGNRIEIKVVVKAQFKATLFATNVEVRIPTPRNTAAVHVTTVTGSAKYKPSENAIIWKMKRFAGQYEAQVSAEVELLASSEKKAWNRPPISMDFQVPMFPASGLNVRFLKVLEHKLNYETVKWVRYMTKAGSYETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKE1</accession>
    <name>A0A0D2WKE1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270090.1">
        <property type="nucleotide sequence ID" value="XM_011271788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKE1"/>
    <dbReference type="InParanoid" id="A0A0D2WKE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27410" checksum="C8BABD607588D5C4" modified="2015-04-29" version="1">MSDLLPLQARPDAAGQPIQPAYAAAPLGGASNMQASLYYPSAPPDDFGNPYVQNQQPMPMPMGAPAGMGYPPLQPQVMYMQMPQQMAACCTCQAAATTRCETCHVPLCAVHVYERRESQQDGNVIGMWRRRICAYCLNFNTFLDYESRTPAAMYLLLCCCCLIPCLAPKISEKAIKEVQLKVWVYNKQNNVPMVIRLERGNNKYQFYLYPHNHPEFINRIASEQAAANQQAAANPPVAASEQVAVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKT9</accession>
    <name>A0A0D2WKT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CD36 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364507.2">
        <property type="nucleotide sequence ID" value="XM_004364450.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKT9"/>
    <dbReference type="InParanoid" id="A0A0D2WKT9"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="4445" mass="485531" checksum="0B454FBE141D7475" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL10</accession>
    <name>A0A0D2WL10_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosylmethionine decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349043.1">
        <property type="nucleotide sequence ID" value="XM_004348993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL10"/>
    <dbReference type="FunCoup" id="A0A0D2WL10">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL10"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL10"/>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL10"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="458" mass="50772" checksum="FE98BC9CD85A9127" modified="2015-04-29" version="1">MTAHTCERSGDHGDHGDDRELLKRAMLCKTADADADTDADTRAAISASPAAPEQPESPEFFEGTEKLLEIEFADSPSCDDRGLRAVTADEWQVVLRLVNCTICRTSAPSSVYNAYVLSESSMFVARRKIVIKTCGTTRLLPALPEFMRIARERCGLSELQDLFFSRKSFLRPEEQPEPHRGFDEEVDYLRSLFGAQSGVVISRDDWHVFCLNPISKRASGHAEVDQTLEVLMTNLDPVAMQQFYRTPAFVNDATTDLTTGVAGIIPGTTICSLLFDPCGYSANGIFDGDCAGVEDDETTSRRRGRLRRPPHYFTIHVTPQPECSFVSFETNAPLHLHNEIVARVLRVFRPSQFSVSVFATRAALGAVSRCPHAGPEASNNTGDDNNCVLEVEVDLQKQQQQQQPHFAETESLCLPSVPCTQSAHTWLVPGFAVQDVFDCDASLQRHIVRYAKFALPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL94</accession>
    <name>A0A0D2WL94_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364729.2">
        <property type="nucleotide sequence ID" value="XM_004364672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL94"/>
    <dbReference type="FunCoup" id="A0A0D2WL94">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL94"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL94"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL94"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270016" evidence="10">
        <location>
            <begin position="28"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="481" mass="52827" checksum="33A276AE4468D493" modified="2015-04-29" version="1">MQIASWIAAAVALRLGLLMLLPSPLLSYIQDPQRYELVTPLTSHRRLLEGLHLMEQGASPYSGDLVHHAPLVLSLVQSVSKQLKVGPVAQVSAAITATATSMAPETQHVRWAVILLTLVSDVLAGLALAGVARYSVRWLDGSRLKNNQNKPEASAATSSLFAVTEKDADDAAQTTLLVWLFNPFSILCFLAHSTASWDAFLIASALYFAVKQHSALAALFCVLAGYSSLYPIALVAPLALAIASHPPVLQLHSAPSSALAAVNSVQAPSDVSTWRVVVFGFWVVAWTLVVALASYLYIDSWDFVDAVFGFIIQVPDLTPNIGLMWYFFTEIFMHFRPFFAWVFQLHVFIYVFPLSVQFRRHPPLLAFAIVTIITVFKSYPSMGDLALVFSMLCMFPQLNPYLRFRFVVGGILTFTTILGPVFFHQWLVGSNGNANFPYGVTLAHAFAVTALALDYCLAYLRREYDIIHGIAVPDGATVVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLQ6</accession>
    <name>A0A0D2WLQ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348878.1">
        <property type="nucleotide sequence ID" value="XM_004348828.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLQ6"/>
    <dbReference type="eggNOG" id="KOG3629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLQ6"/>
    <dbReference type="OMA" id="QHININQ"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF312">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="864"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1466"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1475"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1491"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1516" mass="160226" checksum="E8863B9D8D202532" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM29</accession>
    <name>A0A0D2WM29_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM29"/>
    <dbReference type="InParanoid" id="A0A0D2WM29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="19865" checksum="89F3255BBC305358" modified="2015-04-29" version="1">MYFSISLEDAAPPSANVCEALRPRMRDSGDRCEMGDMKACKCACVPMAAAGLPKFDAGDGCEVAACARFVIETDAYLGRCCRQTKERERERERSCECLFVLLRIGLKGGVVVGIVLNGCLFVCWLVVVAVDFKATERTHQKEMQTKIQIRNGLRGGLVPVVFAWETNHQHETTTTNRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM57</accession>
    <name>A0A0D2WM57_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363768.1">
        <property type="nucleotide sequence ID" value="XM_004363711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM57"/>
    <dbReference type="InParanoid" id="A0A0D2WM57"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="73" mass="7840" checksum="C8CA1BBF0ADA430D" modified="2015-04-29" version="1" fragment="single">MSSAALVKDIPKLVRGFALSANRAASVNQAASGYWNKYKNSAAPVLHLFLITGLGGYLHHLPHLRHAAQSGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMD8</accession>
    <name>A0A0D2WMD8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Ribonuclease P protein subunit p20</fullName>
            <shortName evidence="10">RNaseP protein p20</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363857.1">
        <property type="nucleotide sequence ID" value="XM_004363800.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMD8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMD8"/>
    <dbReference type="eggNOG" id="KOG3631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMD8"/>
    <dbReference type="OMA" id="LHCMGYS"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMD8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.20:FF:000002">
        <property type="entry name" value="Ribonuclease P protein subunit p20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036572">
        <property type="entry name" value="RPP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="127" mass="14177" checksum="232E8FC7D6419700" modified="2015-04-29" version="1">MEVDNSEYDDAQLYNAVKRAPQRLPTRPNDIYVTRSTHFDAQFARAQKLLDSGYSEICLHGLGASINRAINLALQLQQQYMAPLVLSTTTSTVELTDDLQPKAKNVASKSQTRSNSAVHIKVEKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPK2</accession>
    <name>A0A0D2WPK2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347981.2">
        <property type="nucleotide sequence ID" value="XM_004347931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPK2"/>
    <dbReference type="InParanoid" id="A0A0D2WPK2"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="483" mass="50432" checksum="2818DD9B454972E2" modified="2015-04-29" version="1">MELLHPGEQATQSMDNGEHHRDPLLQQAVAFAGQGQSQHTAAVAAAAAVAVAARTDQAETSDARHHSASLTTTKSRLPSSWLRKATAAANPNDAHPIPMMHTKPQQQLPQTMLAGIPQAASGGNTSVISIASSSTSTASTNKRYFLSDQLELLESFYDQNKFPKPSDEEALAAKMDESRARIQQWFRNRRAKERRTQRLGDASTSSEPAPTCLDLMHASLDEENASLRQQLRTLWNSFEFYVPESQQARLPIVSIPSGLLEDMAEGGAGGPSVVGGARPPSLLSATSLAPSSGFASARSTSSMEPLSSAPIPQPGGSSTFELRLPAWSSSSSASSLNSGLSPVVPSKRRHSGAADDASGSAVADAAFAQYSSPSLSVAAGATDSSSHDAPVSYSGETTGTAPAGSSSVGYRRRLSALTHPSHSSVPTLTITVEHLGAESIHHGSAAATESLSASTALPEPDRTAVADSGDPNKRIRLDPLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPM5</accession>
    <name>A0A0D2WPM5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPM5"/>
    <dbReference type="InParanoid" id="A0A0D2WPM5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="333" mass="37193" checksum="22056F59F3B96844" modified="2015-04-29" version="1">MAGASEAATRCLAWLQAVKAAPEGEKHNVAVAVALKLVYQDSVTLQGGEIYRPTGWTTRAIAARLAEQGYQCGHTTVHDWKTKHADSAEWIRSSPLDQVLQLVKESPSCGGQSIFTEDELEYCIRLLEGFARAGQCLNQKQAGAYLVKLSRLPRMSGAPRRQFAGSLPSHEWWNAFLRDARGRLAIRKGRTLELTRIAALQAETLDCLPGLLKQLFDEHPLLVEEPGRISNMDETEITTRFFAGRVICTPSLAKRLHEKRNMAENVRLRPMRRAREQAPDHDDDAPGRISQRARLDSPDQAVQAPPALVDLSHWPNHLGFVPAMFPSQHLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPR0</accession>
    <name>A0A0D2WPR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348073.2">
        <property type="nucleotide sequence ID" value="XM_004348023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPR0"/>
    <dbReference type="eggNOG" id="ENOG502SU48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPR0"/>
    <dbReference type="OrthoDB" id="2121906at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41181" checksum="5C397573ED60E378" modified="2015-04-29" version="1">MTLTEFNPNEMPYTAEWVVIGIAIVNFIVNASVAAYLLYWRNWPPIRAKQLDLFLLSAFAGWSWLLGAMSVMRLIPQVGAMLACNFWTFWYQFLFGSLLWIVCIIMRMYRLYVILVASRMRMSIAKNPRLWIYIRLVALCIPYITFAIIATAVDANGAKPQPTTDGYMQELCSLRSWALYVLFMLTTCYLAVCAFFIYKLRNIRKFLNEYRESKIAFGCIVFLFIVYIVIHVGSYQRQVWGRVLATCLILVTINVAYWVFVGRIVYGRWFNPEEFLAEFQATKDYEYNSTSKQSKSKGTKSVKSNPDTSRSSTEQKSNVENQSEFEIRAEGGTFALTTMEEVEIPDDAAATETVAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPS5</accession>
    <name>A0A0D2WPS5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348097.2">
        <property type="nucleotide sequence ID" value="XM_004348047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPS5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPS5"/>
    <dbReference type="eggNOG" id="ENOG502RZ7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPS5"/>
    <dbReference type="OrthoDB" id="2189509at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="959" mass="102441" checksum="42082132D8893BFC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQG3</accession>
    <name>A0A0D2WQG3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347384.1">
        <property type="nucleotide sequence ID" value="XM_004347334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQG3"/>
    <dbReference type="STRING" id="595528.A0A0D2WQG3"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQG3"/>
    <dbReference type="OMA" id="TMASHVH"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="786"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="893" mass="90661" checksum="16F3D712440F432E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQN4</accession>
    <name>A0A0D2WQN4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347464.1">
        <property type="nucleotide sequence ID" value="XM_004347414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQN4"/>
    <dbReference type="InParanoid" id="A0A0D2WQN4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="319"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1055" mass="109644" checksum="5C1F918C694740A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQX8</accession>
    <name>A0A0D2WQX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348106.1">
        <property type="nucleotide sequence ID" value="XM_004348056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQX8"/>
    <dbReference type="STRING" id="595528.A0A0D2WQX8"/>
    <dbReference type="eggNOG" id="KOG4425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQX8"/>
    <dbReference type="OrthoDB" id="6020087at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="610" mass="65815" checksum="52A4322FE6E6DD00" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQY1</accession>
    <name>A0A0D2WQY1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQY1"/>
    <dbReference type="eggNOG" id="KOG4732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQY1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQY1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="617"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1659"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1888" mass="202286" checksum="99614A4AEC25931A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR93</accession>
    <name>A0A0D2WR93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346718.1">
        <property type="nucleotide sequence ID" value="XM_004346668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR93"/>
    <dbReference type="FunCoup" id="A0A0D2WR93">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR93"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR93"/>
    <dbReference type="OMA" id="VCIFDVV"/>
    <dbReference type="OrthoDB" id="2020362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="49"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="436" mass="47794" checksum="288861C7937D2A60" modified="2015-04-29" version="1">MSNGSTSAAAASAASTMDINDTAAIRATHYAHFEPGMHRMNHGSFGAPPKCVIDAQLEGYMRFLAQPDRMYFDELIEGQGLDAVCTDIARLINYPNHKAITLVENATTAAVIVAESIARKFTAGVYARGDAILLFDTTYNAVKNIFIDIVERVGGRLVIQPNPFPIASDDDLLRALDAGLDACGSSKVRLVALDHITSVPAYLVPVTTMIARCRARGVDQIFVDGAHAVGNCPSLDLEAMDADFYCSNLHKWMFAPPGAAFFFAKPSLQASLHHPIVSHNYKLGLPRESSWTGTRDYSAYLAVARAIQFYLSWNKDVENATQSPFANMAIYRRNNAMAVRAAQMLAAAFGTQLPTPISMMTSLAMVELPPALGLLDNAAAHRLRCDLRDRHKIELIVWVNEAATPRRSFIRLSAQIYNDWAEYELLRDVVLGLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRA0</accession>
    <name>A0A0D2WRA0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346729.1">
        <property type="nucleotide sequence ID" value="XM_004346679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRA0"/>
    <dbReference type="FunCoup" id="A0A0D2WRA0">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRA0"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRA0"/>
    <dbReference type="OMA" id="GKIMEWY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRA0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000003">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="552" mass="61799" checksum="5FB5C3559CACA68D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRE5</accession>
    <name>A0A0D2WRE5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346784.1">
        <property type="nucleotide sequence ID" value="XM_004346734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRE5"/>
    <dbReference type="STRING" id="595528.A0A0D2WRE5"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRE5"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRE5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="444"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="807" mass="86340" checksum="8F8B9A40022547AD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSD3</accession>
    <name>A0A0D2WSD3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STE/STE20/SLK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSD3"/>
    <dbReference type="STRING" id="595528.A0A0D2WSD3"/>
    <dbReference type="InParanoid" id="A0A0D2WSD3"/>
    <dbReference type="OrthoDB" id="10027016at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSD3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001298">
        <property type="entry name" value="STE20-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="48292" checksum="0A74FC54C405EB68" modified="2015-04-29" version="1">MVRKGKVKLSKHVITGVDPQTVWDLVQEVGDGSFGKCRNKKSAQISAMKVIAVESNEELEDFQVEITILKESSHPNVCKLFDAYFFKDVLWLALEFCEGGALDDIYSDLEKPLTEPHIRVVNHYMLQALDYLHRNRVIHRDIKAGNILVTEFGDLKLADFGVSARLKTNEQKRNTFIGTPYWMAPEVIACETNKDTPYDSLCDIWSLGITAIEMAEMNPPLHDMHPMRVLFKIPKAAPPVLQQQSKWSDEFHDFLRTLLVKDPLQRPNAQACLAHPFVKDATDVSCIRELYQFYKSPNAPRRRSSNAGVEMARSTDMLSQVGLATTLNVPASAPAAPAAASSPASTNGNASAADATVLVVPVASSPSSVHKLSVQPATPDKTPEHAPVLAVVEQPAAPATVPAPAQEPHQPQQPASPPKQPVVCARAGSSQPDSRCRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSR9</accession>
    <name>A0A0D2WSR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346860.2">
        <property type="nucleotide sequence ID" value="XM_004346810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSR9"/>
    <dbReference type="STRING" id="595528.A0A0D2WSR9"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSR9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSR9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="12">
        <location>
            <begin position="179"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1046"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121133" checksum="61EF60DBB12BEB32" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT12</accession>
    <name>A0A0D2WT12_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT12"/>
    <dbReference type="FunCoup" id="A0A0D2WT12">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WT12"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT12"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="369"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1122" mass="119276" checksum="8EB893E86B0F5D92" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT28</accession>
    <name>A0A0D2WT28_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345534.1">
        <property type="nucleotide sequence ID" value="XM_004345484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT28"/>
    <dbReference type="STRING" id="595528.A0A0D2WT28"/>
    <dbReference type="eggNOG" id="ENOG502QQBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT28"/>
    <dbReference type="OMA" id="YNYCGEN"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="441" mass="47700" checksum="64CFDEF598320E08" modified="2015-04-29" version="1">MSAFTIFVSPLKQTTRIDYSVKLKDAATSGEGMELLKDLTNTRTALLDLMGKWEAPQDAFMSTANAYLSLLRGLVDQVDGASSPPQQPAAAPAADGAAADSQAAATAAASGSFNKLRKLIAFYWTNTLGKHHISSDTDVQFELISMLEDIAIWHTKKANLTLSAASAEENDLKDAYKLLRVAAGILLFIESTQIARLTTSASPSDTNPAAVRAYSSQLLAEAEEVSLARAVEKKHSPSLLAGIARDIADKFDAAAKGIAQVKLDKVDKWSKYLAWKTKYYQAAAYMFLGLDLLSKDDCGNAIRAMTEAEKLLEQANALGKVFVDCEPKTPLKIHELPATQALSRQLRDSLAKAKRENDFIYFKKVPTELPELAAPRAVVEPEPYALAPLSSRWTAQMYQSLNVSKVIPDVVPAAALEREEANSKAAAKAQHPVDKGACTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTX6</accession>
    <name>A0A0D2WTX6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346354.1">
        <property type="nucleotide sequence ID" value="XM_004346304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTX6"/>
    <dbReference type="InParanoid" id="A0A0D2WTX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="873" mass="93622" checksum="222C8EE32CE4388E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUD4</accession>
    <name>A0A0D2WUD4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345557.2">
        <property type="nucleotide sequence ID" value="XM_004345507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUD4"/>
    <dbReference type="FunCoup" id="A0A0D2WUD4">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUD4"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUD4"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUD4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="454"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="781" mass="87964" checksum="2A67FC7BF84E55DC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUN8</accession>
    <name>A0A0D2WUN8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUN8"/>
    <dbReference type="STRING" id="595528.A0A0D2WUN8"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUN8"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="566"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="834" mass="85036" checksum="A9AA34D58E9F8900" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUV6</accession>
    <name>A0A0D2WUV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344436.1">
        <property type="nucleotide sequence ID" value="XM_004344386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUV6"/>
    <dbReference type="FunCoup" id="A0A0D2WUV6">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUV6"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUV6"/>
    <dbReference type="OMA" id="DKVCRKT"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="245" mass="28018" checksum="1615998E6334F6EF" modified="2015-04-29" version="1">MKILENVNLDALGSSLSVVRGDKRMVGRVESYSCKLAGTDKKQYKQNFTAEYTEPEHILAFSPPQSMSVSPLSQFNELCYESCNRKTLFYLIAVLNSAFPDYDFSTLKSHNFSKERFDMVSNYINSTLSTELQDEWVAIAAKFWSSIDADVALRDCAIYSYVPETDADNPFAEDGNLWSMNYFFYNHKLKRIVFFSCRCLSVTAPCPEDEMASWGEEDEFMEHYEADDEPSSGYYGSNNTGYPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVD2</accession>
    <name>A0A0D2WVD2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343806.1">
        <property type="nucleotide sequence ID" value="XM_004343756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVD2"/>
    <dbReference type="FunCoup" id="A0A0D2WVD2">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVD2"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVD2"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVD2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="255"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="445" mass="51474" checksum="53DF4DDE114284F6" modified="2015-04-29" version="1">MDDDDFMDDDGGEEDYGLEYESDEGSEPDVDLENQYYNSKALKDSEPRDALESFEQVLTLEGDTQGEWGFKALKQMVKLNFRLGKHQAMMKKYRQLLTYIKSAVTRNYSEKSINSILDYISVSNQMDVLQEFYETTLETLREARNDRLWFKTNLKLGKLYFDREEFGRLTKILKQLHESCQNEDGSEDQKKGTQLLEIYALEIQMYTAQKNTKKLKALYERSLRVKSAIPHPLIMGVIRECGGKMHLGEGAWAEANQDFFEAFKNYDESGSSRRIQCLKYLVLANMLMQSEINPFDSQEAKPYKNDPEILAMTNLVSAYQRNDIAEFEKILRDNKKNIMDDPFVRAYVEDLLKNIRTQVLIKVIKPYTRIGLPFICSELNISLAEVEHLLVSLILDQQIAGHIDQVNQLLVLDQQSLRQGTQKFVAVDKWVRNLTTLHSSLIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVL8</accession>
    <name>A0A0D2WVL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344252.1">
        <property type="nucleotide sequence ID" value="XM_004344202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVL8"/>
    <dbReference type="STRING" id="595528.A0A0D2WVL8"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVL8"/>
    <dbReference type="OMA" id="HRRLEYP"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVL8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="34753" checksum="2B3C7F2683B31D49" modified="2015-04-29" version="1">MSVVTRAWAETMRRLQRECNSFQQPGSSKSISHKFAVAGVHLGYCRPADAQAILAAVPGVFALEPSTVANEPAVLTLSPALNRDSPAARTAAVMGVMQALRRSNTMEALAGWRDELFAVAPEYGGPVYFEIERAAASLLGVSQFGTHLNGYVRTGASGNPAQDLKMWVSRRSLTKPTWPGKLDNLCAGGLPSGMSPHENMRKECSEEASVPAELSGRCVAVGTVSYTSELSRGIFPECQFVYDLELPESFQPVSADGEVGEFYLWDVPTILHSISTPEFKPNCALVFLDFFIRHGILTPDSTPLYPELVSGLHYSGPLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWE8</accession>
    <name>A0A0D2WWE8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWE8"/>
    <dbReference type="InParanoid" id="A0A0D2WWE8"/>
    <dbReference type="OrthoDB" id="2114609at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWE8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="298" mass="31927" checksum="44A32EE59F445FCD" modified="2015-04-29" version="1">MQLLDLFPPNLEREHRSGLDAASRATLHTLRHSPIATYAGASSTLVCGPAQSGKTYLLFSYATRLAAQGRDVVFLCPDRDRLRAVLPFLEHVVTAAARDASSDSLGVSSTTTGDSAAQNAGVAPVTFDQILKRIHIKYIVTSAKLRCFLASAHMTNEPASVVIVDDYLAFFGDANKTTQTLSHAVAKTSALLVETCNYLTSTHPAQPTTLLVADSLLRLVLPPPALVELLERWFPLVVQLGLQSQAQSQSLPPAAGLTHHSMTVLRVNKHDDPFGTALHFTLSANGLSLANAAMRSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWH3</accession>
    <name>A0A0D2WWH3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Presequence protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWH3"/>
    <dbReference type="FunCoup" id="A0A0D2WWH3">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWH3"/>
    <dbReference type="MEROPS" id="M16.A19"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWH3"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="2">
        <location>
            <begin position="646"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1264" mass="136980" checksum="F05D94E8C5B993CF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWI2</accession>
    <name>A0A0D2WWI2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWI2"/>
    <dbReference type="FunCoup" id="A0A0D2WWI2">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWI2"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWI2"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="218" mass="24692" checksum="9E4C1F3B6EF5EB93" modified="2015-04-29" version="1">MQFKFNAKFESAQFSPSFFLIHCSKAFTNQIQYYKATMLGVISKIVTTFHGSSNLETDVENFYDLKCTDILGNPFDFASLRGKVVLVVNVASNCGLTKSNYTELQQIYSELKDKGFEIIAFPCAQFLNQEPETGAKILDFGKTRFGVTFQLMEKTKVNGQEAHPVYRFLRSKTDPSPIDWNFSKFLIDRTGSTIQRFGASVRPKEIEPEIIKLLDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWQ9</accession>
    <name>A0A0D2WWQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="8">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="8"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343370.1">
        <property type="nucleotide sequence ID" value="XM_004343320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWQ9"/>
    <dbReference type="FunCoup" id="A0A0D2WWQ9">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWQ9"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWQ9"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="689"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="852"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1029" mass="110767" checksum="D03582487F163C8D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXI2</accession>
    <name>A0A0D2WXI2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXI2"/>
    <dbReference type="InParanoid" id="A0A0D2WXI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="13152" checksum="B60777781CB661FC" modified="2015-04-29" version="1">MLNRAKHLASPPSFEFSDPDLSSLSLSCAIHETRQASRPNGYDPKVVSVLFRLIMECRLRPVFLSNLFLPRVSWLRLVQRLVTRVAFALHYRKERRTGTFLSLIENEKTTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXK9</accession>
    <name>A0A0D2WXK9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343214.1">
        <property type="nucleotide sequence ID" value="XM_004343164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXK9"/>
    <dbReference type="STRING" id="595528.A0A0D2WXK9"/>
    <dbReference type="InParanoid" id="A0A0D2WXK9"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXK9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="173" mass="18314" checksum="30AE87DC4A71613F" modified="2015-04-29" version="1">MSLSGGAVFVLIVLGSIALYIIGGMSYRRCVVGARGKEMFPNLPFWRKVGSFIKEGFEYTLLCIANRHKEAAVRYHGLDDEENHLPGLDDENDYDADNAEIRARPIPSSLPAPSPAASVGVRQPSQAPSLPVPAATAAAAAAPSVPPATSAALNSTRGFDVGDDDDDEKLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXP4</accession>
    <name>A0A0D2WXP4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXP4"/>
    <dbReference type="InParanoid" id="A0A0D2WXP4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="266" mass="28905" checksum="11DB5418FBC15EB6" modified="2015-04-29" version="1">MRVSLTPCFRIYFFRHRSVEQALHWPVGCRLADSTADKLHYHWCSAPSGSSDTLASVFAFTLDGRLLEWVVPTTALSLDAKIMPIVHALPTPTALASAGSSVFLGISSLNELGREGDLVAVLGHVQAASDVGLETTTKSAFSTFAFHQNAASTSSWHHLWTTEPVVDGELRAASLHTSLVATQAALNERQETLILSDLESGDFLGSISTNTPLACECQPKIHRAVLHPTLPFVLVHFKTPRSCTSLDHVDNHSSCAHLYRLSDQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXW8</accession>
    <name>A0A0D2WXW8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342783.1">
        <property type="nucleotide sequence ID" value="XM_004342734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXW8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXW8"/>
    <dbReference type="eggNOG" id="KOG0088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXW8"/>
    <dbReference type="OMA" id="NDEQHRN"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="202" mass="22221" checksum="489D87AD8E0917FF" modified="2015-04-29" version="1">MGDSLTFKIVLLGEGCVGKTSLVLRYCENRFVDKHISTLQASFLTKRLNIGGKRVNLNIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELKKMLGNDIALVIAGNKSDLEKHRTVSAEAAEQYAASVGARHFYTSAKLSKGIEELFLDLSKRMITEADKRGGTSTVGRKTAIVVDDDVAPKAQSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X059</accession>
    <name>A0A0D2X059_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Maleylacetoacetate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365010.1">
        <property type="nucleotide sequence ID" value="XM_004364953.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X059"/>
    <dbReference type="STRING" id="595528.A0A0D2X059"/>
    <dbReference type="eggNOG" id="KOG0868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X059"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X059"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000041">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="24700" checksum="23CDB109EC36629C" modified="2015-04-29" version="1">MSSAAAAKPILYSYFRSSCSWRVRIALALKGIAYEYRAISLIKDGGEQFKDEFRSVNPQREVPVLEIDGHQLAQSLAIIEYLEETRPDGASLLPKDAHQRALVRQVSDAIAQGIQPIQNLRVLNHVGDEKKVEWARHWINHGLAGLEALLAKTHGKYSVGDTVTMADCTLVPQLYNARRFKVDLSQFPIALAIENELIKLDAFKAAHPSAQPDCPESERGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0H1</accession>
    <name>A0A0D2X0H1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_000607</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365478.1">
        <property type="nucleotide sequence ID" value="XM_004365421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0H1"/>
    <dbReference type="FunCoup" id="A0A0D2X0H1">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0H1"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0H1"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="178"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="370"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE89049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="51743" checksum="03BB81D324F7188D" modified="2015-04-29" version="1">MVAALGGLARRLGRACLRSACSRRWASTTTTTATKPSHPANPSPSPSPDHITLLGTAYPRDRWTNVSPSIQAKLGRGLLTVPNHPLRIIKLRIEQYLNETRPGTDPLLAPRAFAIVDSLSPVVTVQQNFDSLLVPADHVSRQPRDTYYVNQNQVLRCHTSAHQVQTLREGHDAVLIAGDVFRRDEIDASHYPAFHQMEGIRLFSHDTLAKYNPEIAGSPIFEQAGSPTYGETAAKQKSHTALAAAVVERDLKATLDGLARHLFGSEIQVRWVDAYFPFTHPSWEMEVLFHGKWLEVLGCGVVQQQILSNAGVENKLGWAFGLGLERLAMVLFGIPDIRLFWSTDSRFVSQFSEAAALNPGANAVKFQEFSRFLSRSKDTTFWLPSSGFEDNDFFELVRSIASDLVENVQMIDSFVHPKTGRTSKCFRVTYRSYERDLSHEEVNLLHNEIRNRLAADLKVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0L2</accession>
    <name>A0A0D2X0L2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0L2"/>
    <dbReference type="STRING" id="595528.A0A0D2X0L2"/>
    <dbReference type="eggNOG" id="ENOG502RDW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0L2"/>
    <dbReference type="OrthoDB" id="10261701at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0L2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="366" mass="39935" checksum="360D7C5F60DBC5C2" modified="2015-04-29" version="1">MPPTRRRHDAVESDPTRDERAPSPTDHTTTSKRIRLETRAATGQPSSTTTAAPSSDQGAADHASDQEEELDDALQESDALMAASAPPSDVLAAIMYARNLLVAPPVETAHGSASGSSSFTPFAITQRPGAKTAARLASILHSRAQKSSALFPPLALMHQLYAVVDDRTSVDRELMQLKQRNVVRLFRLDVASEDTAIMVFADFVEHVQSVKTPTNEKALESFVTSLLPAVNEMSVTTQQLNSSGIDEAGIGLLMNAGLLTMRSVGSFWFAIPRVGVFNIQLARGRAELLRIVRKAKYKEASEQSLYARVLTKCDVSARFIVLDLIGSDRFERQVQLFESLDDSMLCSSGFRVSTSMTAFSGYFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U2</accession>
    <name>A0A0D2X0U2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270042.1">
        <property type="nucleotide sequence ID" value="XM_011271740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U2"/>
    <dbReference type="STRING" id="595528.A0A0D2X0U2"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0U2"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="303"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="626"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="917" mass="97924" checksum="2960CC5028A8B9EE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U4</accession>
    <name>A0A0D2X0U4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365970.2">
        <property type="nucleotide sequence ID" value="XM_004365913.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U4"/>
    <dbReference type="STRING" id="595528.A0A0D2X0U4"/>
    <dbReference type="InParanoid" id="A0A0D2X0U4"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="44114" checksum="0EB0FFA1B2B35E83" modified="2015-04-29" version="1">MSLHPLESGLDLAVGTLSLGSLERRVAAALFAESEAESHWRAAGTIAVSVTRESGIAFVETAHQRNLPVVAIVNEVIYPEKIALHKLERSGVRVIRLPAEGMRSLTPSLVTDLVARVTAGQPSDVPVRFLLDPVNTTPLTKAVQAATAGLLGELKLPAEVSAAIAIGVELPHTLLSTLIVQTLRERLSVAGSTLIVAELGAPRPGDSDETTIRVAPSDAAIAQSVLQKQVPAAAQAVGLLTGAALVALRSVSHPHQKIALACDGDAAVSQAPPSTNPASKYRGAAVEDLNLPVPVTASQTIAIGAALALMDEHDFDNLPVLDAKKRLVGLLTREKLEARVRAAPSTAEAEQVTPAMYYSFSRKHRYVPIQLDTPLEVLEQFFTQHSIAFVTDDNGWCVSLATPADLQLYLSKRIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X191</accession>
    <name>A0A0D2X191_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
            <ecNumber evidence="7">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aminoacetone synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:20738"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="7"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364583.2">
        <property type="nucleotide sequence ID" value="XM_004364526.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X191"/>
    <dbReference type="STRING" id="595528.A0A0D2X191"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X191"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X191"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="73"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="427" mass="45868" checksum="253C8BA54AEC2062" modified="2015-04-29" version="1">MASSASSRLTMLGRLLASAPASAYSTSAARNKLTDIANAQLAEIRAAGTFKAERVITSPQSALITVASSGSQPVLNFCANNYLGLANHPEVVDAAKEALVTHGAGLSSVRFICGTQDIHKDLEKKIAAFHGREDAILFPSCFDANAGIFETLLTAEDAVISDELNHASIIDGIRLCKAQKYKYKHRDIADLTAQLEASKNARMRMIVTDGVFSMDGNVAPLKEICDLAEKYNALVFIDECHATGFFGKTGRGTEEFLNVVGRVDIINSTLGKAMGGASGGYTTGPQAVIDLLRQRARPYLFSNTLAPAVVGASSKAFDILQRDTSLCQTVASNTTHFRERMTKAGFTILGDKHHPICPVWLGDARLASEFADAMLKKGIYVIGFSFPVVPKGKARIRVQISASHTREQLDRAVDAFIEVGRSLKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y8</accession>
    <name>A0A0D2X1Y8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349495.1">
        <property type="nucleotide sequence ID" value="XM_004349445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y8"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Y8"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Y8"/>
    <dbReference type="OMA" id="HRRCACI"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="219" mass="23140" checksum="AB36EB1E9BD3EF04" modified="2015-04-29" version="1">MRHHHHHHHHHGFAHHRRCACIGLCTCNSVGAGLLIGGAAVVAGAALVNAATQPQRNVVVVQQTPSPAPVTTTYRTTTTTTTVSPSPSTQVVTQVGYQAQQPYPAAYGGYPPAPAAAGYPMPQPPAGYAPSPVGYPPQQGGYPPQQGGYPPQQGGYPPQSGYPPQMQNAAAPPSYSPVDSRPLPPGWEAKVDPSGRTFYLDHNTKTTSWNDPRNAPYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2F4</accession>
    <name>A0A0D2X2F4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2F4"/>
    <dbReference type="STRING" id="595528.A0A0D2X2F4"/>
    <dbReference type="InParanoid" id="A0A0D2X2F4"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="806"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1047" mass="109061" checksum="E54A6DCD8A26A97F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2I7</accession>
    <name>A0A0D2X2I7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363279.1">
        <property type="nucleotide sequence ID" value="XM_004363222.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2I7"/>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2I7"/>
    <dbReference type="OMA" id="SMASIEM"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="275"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="4">
        <location>
            <begin position="1397"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="936"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1458" mass="151302" checksum="4030179A94A8C088" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T2</accession>
    <name>A0A0D2X2T2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="12">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2T2"/>
    <dbReference type="FunCoup" id="A0A0D2X2T2">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2T2"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T2"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="601"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="609"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="662" mass="74495" checksum="AE7FFAA144690E86" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Z4</accession>
    <name>A0A0D2X2Z4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348033.1">
        <property type="nucleotide sequence ID" value="XM_004347983.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Z4"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Z4"/>
    <dbReference type="eggNOG" id="ENOG502QQB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Z4"/>
    <dbReference type="OMA" id="NFFALCT"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Z4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="627"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="851" mass="96025" checksum="3D6A1DA73D06F80B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X365</accession>
    <name>A0A0D2X365_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347263.1">
        <property type="nucleotide sequence ID" value="XM_004347213.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X365"/>
    <dbReference type="InParanoid" id="A0A0D2X365"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="28751" checksum="025A47C2FF73352F" modified="2015-04-29" version="1">MAEQNELAAEQQQQQQQQQQQQAQQVRTQPQDDDKLSTNTAATAQVECAAAATAAEPAVVVDTTHYSVSMAGGSLRSALCVPNSQPAVTDPEQLDATFGIEFPSPMRTQLVLMRQMFEHYRAQLDALLGAREELTKLMKSDAFMCFVRVRAQHNHNQQTKFVTFVLRQLAGAFAACNLTYLAYRFASPAACHTAFIEGLEDAVTRALIPDDDLPKPHSEPAPLMPNSNISLALPAAVQLHMDRICAYARQTRPQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3B7</accession>
    <name>A0A0D2X3B7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3B7"/>
    <dbReference type="STRING" id="595528.A0A0D2X3B7"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3B7"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="827"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1014" mass="109552" checksum="F6B45494C17ED790" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C9</accession>
    <name>A0A0D2X3C9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347532.1">
        <property type="nucleotide sequence ID" value="XM_004347482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C9"/>
    <dbReference type="FunCoup" id="A0A0D2X3C9">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3C9"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3C9"/>
    <dbReference type="OMA" id="MVRNATW"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3C9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="518" mass="56625" checksum="83A8EB90B99F17FC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3G4</accession>
    <name>A0A0D2X3G4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_004933</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347684.1">
        <property type="nucleotide sequence ID" value="XM_004347634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3G4"/>
    <dbReference type="FunCoup" id="A0A0D2X3G4">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3G4"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3G4"/>
    <dbReference type="OMA" id="IMLQHRT"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3G4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000150">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021536">
        <property type="entry name" value="DNA_ligase_IV_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11411">
        <property type="entry name" value="DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="455"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="762"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="1020"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="953"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1107"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE94264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132670" checksum="6C1172B0F77E0BA5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3P1</accession>
    <name>A0A0D2X3P1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3P1"/>
    <dbReference type="STRING" id="595528.A0A0D2X3P1"/>
    <dbReference type="InParanoid" id="A0A0D2X3P1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3P1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="441" mass="49886" checksum="695B083BCCDEC045" modified="2015-04-29" version="1">MAFIAWQLEHEVAWDIALTLHHQCEVEGAAARRLTLRRPPPPLSQEAMTYYESMPKLPTAGTKPAWARVEVHGFEVRVPAAPPAVNISSVRPPLGAFVPRDELLQITGLQCLPLEDHQSLAELFHGFWDGPINQTLSSLYISAISTVFRHHPDSTYLVHSNTLPLDQFDELRAMGFNIAVVRYDALRALTFGNLPGQRWLLQDRVRYAEHRNIGSHMSDLMRAILMHQCGGIYMDLDSVLLRPLHFLNRAFTMEPMRPNHLRVQYIKMDGVSSLLSCSEVIVIRPQPVDDGASMILSPYVVRGDFGLVPGLLAFGPRDPFIYMMMQVFDEPYNPDCFSCVGPVAVNKAYMATSAHERLRLQVYPADVMFGPFWRGVMDKFDEFWQTTTDERGQALVNEAVQFGFTQHLYGGGQGAPAFQNNSYIHRLVLETQLIPLPDLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A4</accession>
    <name>A0A0D2X4A4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4A4"/>
    <dbReference type="FunCoup" id="A0A0D2X4A4">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4A4"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4A4"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="10">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="11">
        <location>
            <begin position="472"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="9">
        <location>
            <begin position="869"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1224" mass="133541" checksum="90C68BC0780ECC0D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X558</accession>
    <name>A0A0D2X558_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X558"/>
    <dbReference type="STRING" id="595528.A0A0D2X558"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X558"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="757"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1138" mass="123992" checksum="CC4901A6C33E0BE7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X598</accession>
    <name>A0A0D2X598_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Atypical/ABC1/ABC1-C protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X598"/>
    <dbReference type="FunCoup" id="A0A0D2X598">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X598"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X598"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X598"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="412"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="898" mass="97877" checksum="8A82635244EF7DF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5J0</accession>
    <name>A0A0D2X5J0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343061.2">
        <property type="nucleotide sequence ID" value="XM_004343011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5J0"/>
    <dbReference type="STRING" id="595528.A0A0D2X5J0"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5J0"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5J0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="62957" checksum="959572ACC729B9C1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2W2</accession>
    <name>A0A0D2U2W2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2W2"/>
    <dbReference type="InParanoid" id="A0A0D2U2W2"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2W2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253114" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="420"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="761" mass="85119" checksum="AD41B45BB97E323A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3S1</accession>
    <name>A0A0D2U3S1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3S1"/>
    <dbReference type="FunCoup" id="A0A0D2U3S1">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3S1"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3S1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3S1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="483"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="833" mass="93295" checksum="129EA48883D4A4A7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3Y1</accession>
    <name>A0A0D2U3Y1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349826.2">
        <property type="nucleotide sequence ID" value="XM_004349776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3Y1"/>
    <dbReference type="FunCoup" id="A0A0D2U3Y1">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3Y1"/>
    <dbReference type="InParanoid" id="A0A0D2U3Y1"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3Y1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="668"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="727" mass="78593" checksum="452AEF115BAE8BEC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3Y7</accession>
    <name>A0A0D2U3Y7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3Y7"/>
    <dbReference type="InParanoid" id="A0A0D2U3Y7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="138" mass="15237" checksum="BAE38FA3D8CEDF53" modified="2015-04-29" version="1">MRCRFSMWQHDASFRRGLTLLLPSQPQQELMYTCIPASACLARRHVAVARVETRVSVRGFWHLARAKIERTANGGSVGSGEIGAMLHVCGLCDSLSLAKGYGMTSEEVVYRLLTQQEPPARKNKTRTEAASACVSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5K9</accession>
    <name>A0A0D2U5K9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364616.1">
        <property type="nucleotide sequence ID" value="XM_004364559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5K9"/>
    <dbReference type="InParanoid" id="A0A0D2U5K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="206" mass="22432" checksum="F08A735A2ED02ADD" modified="2015-04-29" version="1">MVQKLPGQDFQVVQAGDAKLYDVQPFGKTHQAVLVNNSAEALKETGLFDPTIETKPSGKLKKKNKQKTTGLASSNAKTSDADQAEVAETASAALASVPSVNLTNVRLALGVFADGCARSAPSDDDHVFFVDQSNYRKYFPPLLWPIYDGLSTIRQSQPQEQKSKSKSNSKKKQMEQADTAMQLDVSELVKTGGSQKQPTRSKRTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6M1</accession>
    <name>A0A0D2U6M1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RasGEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348806.2">
        <property type="nucleotide sequence ID" value="XM_004348756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6M1"/>
    <dbReference type="STRING" id="595528.A0A0D2U6M1"/>
    <dbReference type="eggNOG" id="KOG3541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6M1"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6M1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="317"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="660"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="953"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="981" mass="107757" checksum="4CA83E6FA8767640" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6N7</accession>
    <name>A0A0D2U6N7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6N7"/>
    <dbReference type="FunCoup" id="A0A0D2U6N7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U6N7"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6N7"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6N7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="308"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="631" mass="70264" checksum="C963190B20400053" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6Y8</accession>
    <name>A0A0D2U6Y8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_002154</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348904.2">
        <property type="nucleotide sequence ID" value="XM_004348854.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U6Y8"/>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6Y8"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6Y8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268352" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="17">
        <location>
            <begin position="27"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1119"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1229"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1309"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1341"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1415"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE90926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1465" mass="152878" checksum="97B8850F7A95AF8F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U863</accession>
    <name>A0A0D2U863_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydroxysteroid dehydrogenase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349202.2">
        <property type="nucleotide sequence ID" value="XM_004349152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U863"/>
    <dbReference type="STRING" id="595528.A0A0D2U863"/>
    <dbReference type="eggNOG" id="ENOG502QPX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U863"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U863"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="875" mass="92646" checksum="4DD68423D89229A6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8C4</accession>
    <name>A0A0D2U8C4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase E1 and transketolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349245.2">
        <property type="nucleotide sequence ID" value="XM_004349195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8C4"/>
    <dbReference type="STRING" id="595528.A0A0D2U8C4"/>
    <dbReference type="eggNOG" id="KOG0451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8C4"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8C4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="593"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="941" mass="104537" checksum="ED1EE03D839B00BF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBE2</accession>
    <name>A0A0D2UBE2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364187.1">
        <property type="nucleotide sequence ID" value="XM_004364130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBE2"/>
    <dbReference type="FunCoup" id="A0A0D2UBE2">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UBE2"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBE2"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="342" mass="37899" checksum="143A268209BC9AB6" modified="2015-04-29" version="1">MDYLPGQEAAELPYQTHPELREETMCPECRRPTEILESHQTGDYVCTACGTVVGDRLIDFNSEWRTFANDKGEEHGDPSRIGSAVNPLLNGSDLTTTMAQGFNAESKAISRAHAKTTANQIDRQLQKAFRLIGDFGERMHLPSNITLKAKQIFKQMEEHYTRERNGAASQFGAIVGGKGAKAVAAASLFLACRLEKVSRTYKEITAVSHVREQEISRASSEIKRILGIHSTVVDVSEYVPRLGDHLSLPLNVTMLATQIAQRANEGLHALAGKSPVSIIGASIYMASQATTDHKRTLEEIARHVGSTVPTLSKWYKELYSNRETIFPEKNEFRANLHLLPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDN0</accession>
    <name>A0A0D2UDN0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDN0"/>
    <dbReference type="InParanoid" id="A0A0D2UDN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="34261" checksum="50E1605C27A5324E" modified="2015-04-29" version="1">MEVAQLSHSGSHPGTGFASHYEDRDAVENEQTQRLLTSPKRSRLAAKRPLEESAQSDQLVGEPPVLTPSTSTSNNTNDSTTSAASIRRRRTDSHPAAASVTAIDSAHTDEPNGHSDAAATDDAMAMATTDDAAAAAAVAETPDADNASATAHVNADSSPTDSTPMSTMSSSSTSSASSSSSAPASRGTASTTLSHTPARPSWTASPAKLGALLGNGASSRGFASSSASIPRPAIDIYTEDEVAQLALKLNTPPRIAPQIYQIIDSPDQGWIAGTKWGPTLKLCGFSCSSPSLPRPLPRVFDRMRELHARETGISPSSSHGDCENARRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDQ5</accession>
    <name>A0A0D2UDQ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aquarius</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UDQ5">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDQ5"/>
    <dbReference type="eggNOG" id="KOG1806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDQ5"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003210">
        <property type="entry name" value="RNA helicase aquarius"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1697" mass="189817" checksum="19D3EBAEE145E281" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE88</accession>
    <name>A0A0D2UE88_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348058.1">
        <property type="nucleotide sequence ID" value="XM_004348008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE88"/>
    <dbReference type="STRING" id="595528.A0A0D2UE88"/>
    <dbReference type="eggNOG" id="KOG4013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE88"/>
    <dbReference type="OMA" id="HRAFDQC"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE88"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.380:FF:000001">
        <property type="entry name" value="Copper homeostasis protein CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="249" mass="26225" checksum="5C1E13BD92DA1BBB" modified="2015-04-29" version="1">MVQLEICIDSVESAIAAQQGGANRVELCSALFEGGLTPSVGMLKCVLKAVSVPVFVMIRPRGGDFLYSELERAVMHEDVVALKAAGAHGIVLGALNADGTIDVDFCRALIAAARPLPVTFHRAFDMSRNLEESMSALISLGVERVLTSGMEATAFEGCDNIRAMIAQAEGSGLIVVPGGGITERNLPKILKTTGATECHCSARQSYDSRMVYRNTGVFMGGTLRPPEFSTSITHAGRVAGVVAAARLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEE1</accession>
    <name>A0A0D2UEE1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_004277</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348102.1">
        <property type="nucleotide sequence ID" value="XM_004348052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEE1"/>
    <dbReference type="STRING" id="595528.A0A0D2UEE1"/>
    <dbReference type="eggNOG" id="ENOG502RVFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEE1"/>
    <dbReference type="OMA" id="CIWIAIR"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="74"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE93491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="239" mass="27165" checksum="A52A1A8399972CE4" modified="2015-04-29" version="1">MSSKAASSSAPKAAAVTGESIFVNTHLFIIELLSDQDRLVAYLRETDPAVIVPIVVFLLTLVFSSSKGRSISFGDRLVGWWLLFNGILIHLFLDGMVGFLKRMPSLYEEYGRLDRRYLERDPFVMVISLCELVVYTPLCLWAYRALHRNDALTHPLIILISAIQWTGTWVFAGAEIFADFPNIPADLNLEFKSHHIIHFWVLFVAANALWTFLPMYLIYRSSAAIAKRLREADKLAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEN2</accession>
    <name>A0A0D2UEN2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEN2"/>
    <dbReference type="InParanoid" id="A0A0D2UEN2"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252557" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1017" mass="108111" checksum="0EE5E16D97F7092A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGJ3</accession>
    <name>A0A0D2UGJ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347622.1">
        <property type="nucleotide sequence ID" value="XM_004347572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGJ3"/>
    <dbReference type="STRING" id="595528.A0A0D2UGJ3"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGJ3"/>
    <dbReference type="OMA" id="REINGCA"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF40">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="556" mass="60054" checksum="D3AD4891100BBE10" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGU7</accession>
    <name>A0A0D2UGU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGU7"/>
    <dbReference type="InParanoid" id="A0A0D2UGU7"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGU7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="RRNA METHYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453:SF1">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="253" mass="27037" checksum="412DC99482233E18" modified="2015-04-29" version="1">MALTLDLSRRILNFLASSKSPPGINPARMQRIAQVVGSRSSLRLVLENCMDPHNASACIRTAESFGIAHVHVIESFSTFRPSETVASGAHTWTLVHHHPSVEHCRAALAEANCALVASDLSGNATELLHGVRSWLPSLSTLTTEQRRALTNVLDERAAIAAIRLTPDSVLKHEAAAPPTPPATPIVKAHASPSLNLSCAVAATLGTLQGINLLDGLPMSQDEQTILQVRFLLSHGSRTMTELLRRAGIEVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH17</accession>
    <name>A0A0D2UH17_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346734.2">
        <property type="nucleotide sequence ID" value="XM_004346684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH17"/>
    <dbReference type="STRING" id="595528.A0A0D2UH17"/>
    <dbReference type="InParanoid" id="A0A0D2UH17"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26453" checksum="3844A16E025D05E2" modified="2015-04-29" version="1">MPRTIYIVRHAERLDLVDATWIPAAARPWDPPVSEHGLRQARHTGSRLARYPVARVFTSPFLRCMQTAAEIVAGMAGDESLASQVLVNVEHGLAEFMCKAWFEAKPEMLSLEDMVAQVPTMNLEYQSQMSFFYPETIEMMSRRYQRCIRNIVALLGPDEHCVIVTHGYGVQFIVEDLDPSAVVMETPYSCISVVTEKPNAPGKFTARLVADASHLEKVNSSRHAPSTHEVASKPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH38</accession>
    <name>A0A0D2UH38_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH38"/>
    <dbReference type="InParanoid" id="A0A0D2UH38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="122" mass="13324" checksum="8B6F9F6254B8C23D" modified="2015-04-29" version="1">MTLGLSVVVFSFCTGKIQWLLAPLLGNPVHLALALSRSLSPVRGLAPNRAARVGPPVAQRDKCWRMRMVVCCGAEKKKGLVNLVVFQKHAIVANRPSPFSEAANSHSGSLRAYRTEPSFRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI47</accession>
    <name>A0A0D2UI47_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4 13"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347061.2">
        <property type="nucleotide sequence ID" value="XM_004347011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI47"/>
    <dbReference type="FunCoup" id="A0A0D2UI47">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UI47"/>
    <dbReference type="InParanoid" id="A0A0D2UI47"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI47"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="483"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="555" mass="60091" checksum="4F45321CD5F9FC99" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIN8</accession>
    <name>A0A0D2UIN8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite exporter TauE/SafE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346209.1">
        <property type="nucleotide sequence ID" value="XM_004346159.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIN8"/>
    <dbReference type="STRING" id="595528.A0A0D2UIN8"/>
    <dbReference type="eggNOG" id="ENOG502QWNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UIN8"/>
    <dbReference type="OMA" id="NMVHKIQ"/>
    <dbReference type="OrthoDB" id="434519at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UIN8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69151" checksum="B6DC1BB0D854E894" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKX2</accession>
    <name>A0A0D2UKX2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKX2"/>
    <dbReference type="STRING" id="595528.A0A0D2UKX2"/>
    <dbReference type="InParanoid" id="A0A0D2UKX2"/>
    <dbReference type="OrthoDB" id="5964374at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050433">
        <property type="entry name" value="Myc_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45851">
        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="597" mass="62543" checksum="7E64901FC46DFCB2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM17</accession>
    <name>A0A0D2UM17_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor unc-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COE family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM17"/>
    <dbReference type="STRING" id="595528.A0A0D2UM17"/>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UM17"/>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UM17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor COE DNA-binding" evidence="3">
        <location>
            <begin position="334"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="975" mass="105919" checksum="79866F38AA6C477E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMU4</accession>
    <name>A0A0D2UMU4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMU4"/>
    <dbReference type="STRING" id="595528.A0A0D2UMU4"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMU4"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMU4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="85"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="582" mass="65978" checksum="362F1FDDD8DF7C15" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQZ6</accession>
    <name>A0A0D2UQZ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_009075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270808.1">
        <property type="nucleotide sequence ID" value="XM_011272506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQZ6"/>
    <dbReference type="FunCoup" id="A0A0D2UQZ6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQZ6"/>
    <dbReference type="InParanoid" id="A0A0D2UQZ6"/>
    <dbReference type="OrthoDB" id="3364639at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="418"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="715"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE97446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="779" mass="88211" checksum="60922A763C76DA21" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URX7</accession>
    <name>A0A0D2URX7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270839.1">
        <property type="nucleotide sequence ID" value="XM_011272537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URX7"/>
    <dbReference type="STRING" id="595528.A0A0D2URX7"/>
    <dbReference type="InParanoid" id="A0A0D2URX7"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252865" evidence="3">
        <location>
            <begin position="31"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="5">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="6">
        <location>
            <begin position="456"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="784" mass="88231" checksum="27B2884CDA916CDC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFF2</accession>
    <name>A0A0D2VFF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364987.1">
        <property type="nucleotide sequence ID" value="XM_004364930.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFF2"/>
    <dbReference type="STRING" id="595528.A0A0D2VFF2"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFF2"/>
    <dbReference type="OMA" id="FEVWYSQ"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="267"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="566" mass="61552" checksum="7843A5E0EBA21F1E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHV5</accession>
    <name>A0A0D2VHV5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365844.1">
        <property type="nucleotide sequence ID" value="XM_004365787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHV5"/>
    <dbReference type="InParanoid" id="A0A0D2VHV5"/>
    <dbReference type="OMA" id="SHEDKPT"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="378" mass="39052" checksum="27EC11854EF6378D" modified="2015-04-29" version="1">MEAQQTPAAASEQQEQPQQQQDSATTAAASSSTIVTIASSGRPPSARRRAKRRLDEDDDSRQLNAAKHARLEAADKPQQQREAQPSLNESAHASSSSSSISSSQNSGSSSSSSSSASGSGSEPAAPHAPAEAQPQPQPQPQAGQPQADQNQAAASSSSSASAPSATPGASLAPSSVDLTDDTDDIVVLGASSAPSAAAASGGGTSRSRRTQASTASAHDADDDIIISSSSIAAAPPTRAILGSSRHRAWLPRLQSLFGSNTGTDVSAFESVLARLESSDQMGDSTDEDHRQQHPHLIFNAVVPMFHMPMIRPPQPPPVDQASNLPPVAPPPPTKKAVQEANSRNNLSEDAPSAQFVGQSCPQEACIPCTYLHLEVQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKC6</accession>
    <name>A0A0D2VKC6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364645.1">
        <property type="nucleotide sequence ID" value="XM_004364588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKC6"/>
    <dbReference type="STRING" id="595528.A0A0D2VKC6"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKC6"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKC6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="50268" checksum="DBB7968B90F08268" modified="2015-04-29" version="1">MHSIQVVSPVDGSIVATRTLATAEEVDAVIERSKVAQKAWGKVPVKERVAICLKFVDAFVAGKDEIAKELTQQMGRPISQTPGEVNGMADRAKYMISTAEEGLKDVEFHDKPGFIRFIRKDAIGVILVVAAWNYPYLIAVNCVIPAILAGNSVVLKHSAQTPLCAERFADAFKAAGLPENVFQFVHMSHAHTERAILNPSVAFVNFTGSVAGGHEVANACGKRFIGCGLELGGKDPAYVRDDCNLDHAVENLVDGSFFNSGQCCCAIERIYVHEKVYDEFVKKFVELTKQYRLGNPNDANTNLGPMVKTGAADFVRKQIKDAVAAGAVSLIDESHFPASKAGTPYLAPHVLVNVNHSMSVMKDESFGPVIGIMKVSNDEEAIKLMNDSPFGLTAAIWTNDYDAAIRIGDQIETGTWFCNRCDYLDPALAWTGVKDSGRGCALSKLAWEHLTQYKSFHVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM27</accession>
    <name>A0A0D2VM27_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5898 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349089.1">
        <property type="nucleotide sequence ID" value="XM_004349039.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM27"/>
    <dbReference type="eggNOG" id="ENOG502ST1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM27"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045417">
        <property type="entry name" value="DUF5898"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871:SF1">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19250">
        <property type="entry name" value="DUF5898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5898" evidence="3">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="780" mass="84723" checksum="36D237DAD68E2BDE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMI6</accession>
    <name>A0A0D2VMI6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMI6"/>
    <dbReference type="InParanoid" id="A0A0D2VMI6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="100" mass="11213" checksum="64DABF624406C7D7" modified="2015-04-29" version="1">MRDWDSVCTGCIRRGALSKQGACIVVLPSRPTAPSHPSFPYPPHSLLGPSPHRHTQRGRGQTRQALPWPMARVCARAPSVYKASRWPLPQPRFFSNETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNB1</accession>
    <name>A0A0D2VNB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNB1"/>
    <dbReference type="STRING" id="595528.A0A0D2VNB1"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNB1"/>
    <dbReference type="OMA" id="LALNTMH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019755">
        <property type="term" value="P:one-carbon compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF9">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="32762" checksum="E787BCC9D47848AD" modified="2015-04-29" version="1">MSAERNFQALNSHDDDVELRDPLSHSRASAAAADVEAQPVYDRNDPIEKGKRRKILIRAVLGELVCTTIFLFTVMAAGLNYGTGGPVAAATGSLMGAIVTGFCAVAIIYAFADVSGAHFNPAVTFATLVTQKTSPFKSGLYWAAQILASIIASALLVALFPYENAAAHVVVTVPDGVNLIQALLMEFILTFILVYVIFATAFETVDSNNVKVVTDKDDTKGTGAKNLTIYTTTGNTKAGFAPLAIGLTLGFLCLLGGSVSGGAFNPARTLGPAIVSWTWTDQWVYWLGDFLGAAVAGLIQQFFAHAAVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP14</accession>
    <name>A0A0D2VP14_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363963.2">
        <property type="nucleotide sequence ID" value="XM_004363906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP14"/>
    <dbReference type="STRING" id="595528.A0A0D2VP14"/>
    <dbReference type="eggNOG" id="KOG4394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP14"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP14"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23616" checksum="D10F9D50236B1759" modified="2015-04-29" version="1">MEQEGERQSAAQPSQPPPKQQQQHQQHPKQQPKQQQQQQQQQQQQHSKAPSVANREGHERINFLYQAAHLVLQPRDAAADQTQQQQQQQHDQQDQQPLVANTRLSTHLLKTLKGVRQRLVLRVDHTIKRTVCKGCSALLIPALTSSVRLQSASKRAPFIVVKCTSCGRSRRYRAESDYVPFTDKVGFRGEDAVRLPTLAPTPATTTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPU8</accession>
    <name>A0A0D2VPU8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348398.1">
        <property type="nucleotide sequence ID" value="XM_004348348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPU8"/>
    <dbReference type="InParanoid" id="A0A0D2VPU8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="85" mass="9281" checksum="9B1EFFCD60859331" modified="2015-04-29" version="1">MNVSQASQTLMRAFGSATRASFPVSRAQHVIQSAATIGQNAPKAAVNARFDMQAQRQAQQYWVDMAKNQKLTSNARVYADVPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSU5</accession>
    <name>A0A0D2VSU5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347656.2">
        <property type="nucleotide sequence ID" value="XM_004347606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSU5"/>
    <dbReference type="STRING" id="595528.A0A0D2VSU5"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSU5"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSU5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254474" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="71494" checksum="1B572C70DAF7F71A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT11</accession>
    <name>A0A0D2VT11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT11"/>
    <dbReference type="STRING" id="595528.A0A0D2VT11"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT11"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="9">
        <location>
            <begin position="48"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="428" mass="48625" checksum="CC3509BF2237E380" modified="2015-04-29" version="1">MLNAQKLYYSLAIGSLAENRIGYVEETVLRHSIHPTLELYIVNQRRSGSVRCQEVRVVVLGDPSVGKTSLVRGIADGYVRQAFSNIFSIANSTDGIDISTVVLREKDESMILIVWDFAGQEVYLVSHQFFLRERTVYLVLFDVREDLSLNSRLAFWLRSLHACVPNADIILVGTHIDHPSYTSERQQAQRQNLANLLSTLKESSVSFNVRSTVYINARNSTGAPSMPDLKTALFQAGQKMPFYNQPLDSRYLELRDSLRKRADQLVAQNKPPLCRWHEVVELGQSHDLTEQAIDAFMELLRFQGWVVFHRLANSATPDTSNVPALQPATLLASMNDIVILSPQWFTKTVLTGVITQKPKDRWVKDGIVTRKDLLRNAWKGIDSAICDQFVLLLQRYELLYKIDGDQPGTRFWHSLCHPFVPASLQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT40</accession>
    <name>A0A0D2VT40_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Squalene synthase</fullName>
            <shortName evidence="11">SQS</shortName>
            <shortName evidence="11">SS</shortName>
            <ecNumber evidence="4 11">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT40"/>
    <dbReference type="FunCoup" id="A0A0D2VT40">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VT40"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT40"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT40"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="49183" checksum="F8BCB6F5B071E706" modified="2015-04-29" version="1">MERNKENQSFSSAVENFLFLYYTKTMASLILHPDELWALCKFKFLGGQQAIMPKNDLSALPESMQKCYRLLEATSRSFAAVIQALDGELRPAICIFYLVLRGLDTIEDDMTLANEVKVPLLVDFHEIIYKTGWTFNGNGPDEADRHLLVDFDVVIAEFLKLRPAYQEVIADITKRMGLGMSKFLGAQVHTKDDYNEYCHYVAGLVGIGLSKIFAASGLESEAVGTSEHLSNSMGLFLQKTNIIRDYLEDIIDGRIFWPRAVWIKYAPNGKLDDFRAPENKAAALACLNDLVTDALAHIPDVFAYMSSLRNQSVFNFCAIPQVMAIATLALVYDNHQVFTRTGVKIRKALAVKLMMGATNMPNLYAIFGEFLANLESRVRTEDPSYEATVAAIERAKVMLRAGLIACPSQPEPSASAKYSQAAFALGLVAAGVWWARRGTAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT67</accession>
    <name>A0A0D2VT67_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT67"/>
    <dbReference type="STRING" id="595528.A0A0D2VT67"/>
    <dbReference type="eggNOG" id="ENOG502QQCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT67"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT67"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="45100" checksum="9271F04757D7E0C7" modified="2015-04-29" version="1">MVLESEVAKLLDLSVIRYSRVWEDHQLLERSLDIRPDDVVLSITRHAHIQVVLSLFSGDNVLNLLLLEPQKIVAIDMSASQNAVLDLKLAAIHMVPHEAFVKLIGIAPATGQERVDIYKHIRSNMSEYAQKYWDHNLATIESSIVKAGRLEKYFDTFHTDYLEKLVPIPVIEAICNAPTLAEQVALVQQHILSNPEVESKFRWYFGEDMLKRQGRDPAQMRFIKDGDISTYIWNKFRSLLTTQLLKDNPYMHVFLLGEYKGSFETAQPYLRPSNYERMRSLLPRLQVVTGSIEEQLSGESSPGSTPLVFSKANLSDIFEYMSAEAADALFLAFANKFRVGGRLAFWNLFVPRCPSDSLRTYFSAHTELAKQVHSHDRLFFYSQFHVEEITKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVA1</accession>
    <name>A0A0D2VVA1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVA1"/>
    <dbReference type="eggNOG" id="ENOG502SEDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVA1"/>
    <dbReference type="OMA" id="RIYATIF"/>
    <dbReference type="OrthoDB" id="6072732at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="18396" checksum="AAC4504CD1A2E1D7" modified="2015-04-29" version="1">MVLFKASLPNVSLMTMIPRPLPAAITFAAFVLALASCTLPASARFYTTAENFKAGNYTLVFAVTVNETYWQPCVDTAITPPLTAGVTTANPISVGQNADCDSGRFRFDISGQSGSIVTVVPTYYSAAVLDASPPSCEIKWDTSIDSSQPACSVLDSREGYHLTGYIFRLVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVY5</accession>
    <name>A0A0D2VVY5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C39-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270587.1">
        <property type="nucleotide sequence ID" value="XM_011272285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVY5"/>
    <dbReference type="eggNOG" id="ENOG502S2XM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVY5"/>
    <dbReference type="OrthoDB" id="293230at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40524:SF1">
        <property type="entry name" value="PEPTIDASE C39-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40524">
        <property type="entry name" value="PEPTIDASE_C39_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C39-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="174" mass="19159" checksum="2865D7E1581CD78D" modified="2015-04-29" version="1">MFFGVFQQLEAGPPSPYPLFKQCDPAWGDDLIDTETICQVGCLMSSISMAIHGWQIKINGTSSNPQSLNNFLRANNGYIGDDLDESAVPKINPVDISWPADGMHPTNDLSFGTIASYLEMGRVVIANVLHGRHFVLVTAASNNNDTLFVNDPGFNTTYYSYSADVVGWRLFDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW77</accession>
    <name>A0A0D2VW77_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW77"/>
    <dbReference type="STRING" id="595528.A0A0D2VW77"/>
    <dbReference type="InParanoid" id="A0A0D2VW77"/>
    <dbReference type="OrthoDB" id="10690873at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1191" mass="123830" checksum="8F2590F10790C09D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX53</accession>
    <name>A0A0D2VX53_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Zic family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX53"/>
    <dbReference type="STRING" id="595528.A0A0D2VX53"/>
    <dbReference type="InParanoid" id="A0A0D2VX53"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="699" mass="75990" checksum="3E5941BE11BD93B9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY58</accession>
    <name>A0A0D2VY58_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY58"/>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VY58"/>
    <dbReference type="OMA" id="HSSQERM"/>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="585"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="648" mass="67669" checksum="59C11574BC810FEF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZR8</accession>
    <name>A0A0D2VZR8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270797.1">
        <property type="nucleotide sequence ID" value="XM_011272495.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZR8"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZR8"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GRIP" evidence="10">
        <location>
            <begin position="951"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="598"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="902"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1368" mass="146124" checksum="38BAA4EB27FD6E04" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1N3</accession>
    <name>A0A0D2W1N3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1N3"/>
    <dbReference type="STRING" id="595528.A0A0D2W1N3"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1N3"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1N3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="492"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="668"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="903"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="934" mass="102660" checksum="C8CCFCC18E908F12" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1Y8</accession>
    <name>A0A0D2W1Y8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346403">
        <property type="protein sequence ID" value="KJE98372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341162.1">
        <property type="nucleotide sequence ID" value="XM_004341114.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W1Y8"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1Y8"/>
    <dbReference type="OMA" id="RIAVEWY"/>
    <dbReference type="OrthoDB" id="442451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1Y8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="363"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="812"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="960"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1392" mass="150281" checksum="2A3FAF8A2BB0925E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHA4</accession>
    <name>A0A0D2WHA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aurora kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHA4"/>
    <dbReference type="FunCoup" id="A0A0D2WHA4">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHA4"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHA4"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="104"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="381" mass="42493" checksum="F2E5F17647571E44" modified="2015-04-29" version="1">MLAAAAASARAYIGTTSAALNALNTQYEPRAPLGTIHAPQAGANTGRPVKLETTSTAAAPTSTTTTTTTTTFAQTSSASSTPTAAGEAPTAGPDGKRRWQITDFEIGRPLGRGKFGNVYLAREKSSKYIVALKVLYKNQLQRIGVEHQLRREVEIQSHLRHPNILRMYGYFHDEKRVYLILEYAPRGELFKELRKEQRFSEPRTASYILQLARALKYCHGKNVIHRDIKPENVLLGLRGDLKIADFGWSVHTSNRRDTLCGTLDYLPPEMVDRGDYDYRVDLWSLGVLCYEFLVGSPPFYAEDEPSTYLRIRRGDLVFPSTVSAGARDFMSKLMRLNPSERMPLEQAMVHPWILEMTDPNNQPRSALAAASKPVSAMASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI80</accession>
    <name>A0A0D2WI80_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365120.1">
        <property type="nucleotide sequence ID" value="XM_004365063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI80"/>
    <dbReference type="STRING" id="595528.A0A0D2WI80"/>
    <dbReference type="eggNOG" id="ENOG502SSNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI80"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="284" mass="31250" checksum="6342423AF453B1CB" modified="2015-04-29" version="1">MPRLRILTWNISGLDISDASPPGETIATKLERLAFGMLDHDADILCLQEFPVPSDSRMPAHQKTFESLSKLFRELGWEFVNSAPSHCGWSCILVKQPWLERLELASTAGPAVFATFKVPRDDASGFGSSDDNAASSPPTITVASCHLAPFKTGTSQRSAQFQALAQAIKASQSTRSATNSIVIAGDFNARENENEHFAHDGYVDAFSAYCLLNPKERSQLQFTWDSTKNKYHADGFGFTCRFDRIVTKRAKVTSLKMIGNSPCVEADSSFYLSDHFGLVAEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIM6</accession>
    <name>A0A0D2WIM6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIM6"/>
    <dbReference type="STRING" id="595528.A0A0D2WIM6"/>
    <dbReference type="eggNOG" id="KOG1512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIM6"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="521" mass="56816" checksum="9749699F7E8E8DC8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIV2</accession>
    <name>A0A0D2WIV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365485.1">
        <property type="nucleotide sequence ID" value="XM_004365428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIV2"/>
    <dbReference type="InParanoid" id="A0A0D2WIV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="44946" checksum="2222DF19D308E0F4" modified="2015-04-29" version="1">MVFAQLVRRYLTFKAATGTCLLIGGFYGYSHYIKHADDRLNERVSAAGVATAYLHKHQEYETKSPEALNCHAAAQKQLGSLLEQAASVILVGGNRGSGKTWTVRHVLFRHLQKNPDKLVYALTTAGPMTEARLVDALVDTFNLNSPSKVRDVTVGSAGLGMTLVPADAQPTDRYRQAIKAIDKFLDQQKKENKAVLLVVDDLENFGASETDRDIALALMNQLQSWAIDEKLKVIAISSSPVASDSLTDNLHGTQMHRVDIDALNRDEAVAYTKALMSIQNAPNTVTPAFLVEHVGVLPAHLCAAVARLATISGPQLVVELQRDAKKQLVRTMVHSHRVGDTTFYPVLRAILKKQLNIRHPLVLSTSLELLEKKGLVTFNIETMVYTFVSPVVTAAASDLARQSWWHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ12</accession>
    <name>A0A0D2WJ12_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365569.1">
        <property type="nucleotide sequence ID" value="XM_004365512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ12"/>
    <dbReference type="FunCoup" id="A0A0D2WJ12">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJ12"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ12"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="364"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="967" mass="105387" checksum="6F188F85AA24189C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ69</accession>
    <name>A0A0D2WJ69_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ69"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ69"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ69"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ69"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="413"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1161" mass="124315" checksum="FD5A7EAA1663B086" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJZ6</accession>
    <name>A0A0D2WJZ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Glycosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349769.2">
        <property type="nucleotide sequence ID" value="XM_004349719.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJZ6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJZ6"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJZ6"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000019">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000940">
        <property type="entry name" value="PRK00094.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000942">
        <property type="entry name" value="PRK00094.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0327">Glycosome</keyword>
    <keyword evidence="3 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="199"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="351" mass="36799" checksum="EB36C85299EF731D" modified="2015-04-29" version="1">MSPLSVALGIMSKPIVQLPPQKVAVFGGGSFGTAMAVAVARNGHRVAILVRDAQVANEINTQHTNSKYIGDLPLPHNVTATTDINEALAGVSFIFHAIPAQTTFDFLEHRKTVIPADVPIISTSKGISTESLKLMSDLIPEALGRTNQPLAYLSGPSFAKEVIQNLPTAVVVASVATEVAQRVQCLMSSTTFRVYTTDDVTGVEVGGALKNPLAIGAGVIHGMGFGNNALAILVTRGCSEMKKLAIQLGGKPETLAGLSGFGDLMLTCHSAMSRNRTVGYRLGKGETLQAILASMAEVAEGVPTAGAVVRLAAREKLDLPIFKAIGDLLDGKLAAMQALEHLMTLPLRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK58</accession>
    <name>A0A0D2WK58_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349861.2">
        <property type="nucleotide sequence ID" value="XM_004349811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK58"/>
    <dbReference type="FunCoup" id="A0A0D2WK58">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK58"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK58"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="380"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="452"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="504" mass="52941" checksum="874E495A8B91DC0D" modified="2015-04-29" version="1">MQAMEDDLSSYAMPMAVDDHHRHNSSSSSSRHHQQQGTAPAASSSSSFVAGGAPGAPGGAGGATGGGFITHQPRASASSALGAPQQQQQPHSNQHFHLNNAMAAGALAGGGANVAAASAPSSSSSASVSSSMLTAPLASAAGAAATPNAAGGGNNPASAHFASAGTPSTPGGGPSSAVSAGASPAGSRPASSAPAIHDPAGILEGRKLYTAIMKQHTCYDLVPDSGKIIVFEVNLLVRKAFYALLQNGLRSAPIWDSSRQQFVGMLTVTDFINILRFYYKSPLVTMDEVEEHRIQTWREVVSTKLPAKMISVEPMATLYDAARILVMSRIHRLPLIDSASNSAVAVLTHKRILHFMYNSMKQTSPPAFLSHSIGQLNIGTYKNIATASPDTPLIIVLNVFAEKRVSCLPIVDETGVVIDVYAKYDVINLARERTYNNLDVPVLEALSHRAEGFEGVVTCLKTDSFKSILDSIVCTHVHRLIVVDNNKRVIGIVSLSDILTFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK72</accession>
    <name>A0A0D2WK72_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tfdp2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349872.2">
        <property type="nucleotide sequence ID" value="XM_004349822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK72"/>
    <dbReference type="STRING" id="595528.A0A0D2WK72"/>
    <dbReference type="eggNOG" id="KOG2829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK72"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="407" mass="44416" checksum="447D8E7AA6B1E513" modified="2015-04-29" version="1">MTDLARARSKRTRRELIQSDNASDDPSSSLGLDSDPVDHSYDELPSDDLVSDDFQFETPSKAAAAAAAASTAGSSSRKKKPRMDPNAAAAAAAAAVAMVAATPQAAPGLAASTNSAAAEAAAAAAANKGLRHFSMRVCQKVKQKGVTSYNEVADELVTELSSAVDLTPAEKGHYDQKNIRRRVYDALNVLMAMNIIAKDKKSIRWMNFPTNAAHECEQLNVTKFDLMHRLKLKKEHMQELILQQVAFQTLVQRNKDAQEQKLHTFTTEILKLPFIVITTNSNTEIDCQMEEDRTEYFFNFKQAFEVHDDIEVLKRMGMARGLNNKSSTAEDLAAIEQLVDEKLMPYIEEMTSTSSSSSSSSAPPPPAPAISQTGSSARKPARKAKGRRQTQSPAHDPSTPDLNEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKR3</accession>
    <name>A0A0D2WKR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348911.2">
        <property type="nucleotide sequence ID" value="XM_004348861.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKR3"/>
    <dbReference type="FunCoup" id="A0A0D2WKR3">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKR3"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKR3"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="725"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="840" mass="89842" checksum="63AD8787C00D014A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW8</accession>
    <name>A0A0D2WKW8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKW8"/>
    <dbReference type="STRING" id="595528.A0A0D2WKW8"/>
    <dbReference type="eggNOG" id="KOG0702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKW8"/>
    <dbReference type="OMA" id="SMRVKSV"/>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="57118" checksum="99C7A42015369425" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL82</accession>
    <name>A0A0D2WL82_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364713.1">
        <property type="nucleotide sequence ID" value="XM_004364656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL82"/>
    <dbReference type="STRING" id="595528.A0A0D2WL82"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL82"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="220"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="556" mass="60612" checksum="2916416EBE1F0663" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WML3</accession>
    <name>A0A0D2WML3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270220.1">
        <property type="nucleotide sequence ID" value="XM_011271918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WML3"/>
    <dbReference type="STRING" id="595528.A0A0D2WML3"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WML3"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WML3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="341" mass="38984" checksum="B4B79E3896054E0D" modified="2015-04-29" version="1">MSSRGTKRASSDNEPTTRKSRRLAKDEEEEEVLDALPEDYSDPEDDEEDSEVEDKGDDDDDDDDEEDEDDEEQEEEPKKGDKRKPSKKDDAEEEEGDDDEEPEDDDEEGDDGEDDGAEEEGEDAAGDDDDDEAADSDAEPIDDDEFKAQRQEIRLDQATLNRLKTNLQAVEAKRAASKTKTKTERGVLYVGHIPYGFYEEQMRRFFSQFGNVYRLRMSRNKKTGRSRGFAFVEFGDRVVAQTVAETMNNYLIFGRLLQCQLLDKKDVHPQTFKNAKNEFRHISYSLNEKARHNKERDLVQEGNRALKLISKQEMVRARLEAAGIDYDFGGYASNLPEGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN17</accession>
    <name>A0A0D2WN17_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364236.1">
        <property type="nucleotide sequence ID" value="XM_004364179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN17"/>
    <dbReference type="STRING" id="595528.A0A0D2WN17"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN17"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="239" mass="24140" checksum="91DFE109CE2F70F8" modified="2015-04-29" version="1">MDTKRGPGRPPRGTARPPSGADSSATSAPALRPPSQGPVTGPMPVFAAGGASSGGLATVNGSGVASLSSRAALDRELHRAGAPSTSSSGASAGGAGGAAAAAAAAASSSSSTATPSSSMFGASMSGDYLPMSRSAGGSGFHQVHPAYDAAPIDDDARSITRTNLANIAHQIDPYERLDDDVQELLLDMADEFIESVASFACRLARHRQSNTLDVKDVASHLERNWNINVPGYNATDYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNV2</accession>
    <name>A0A0D2WNV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364002.1">
        <property type="nucleotide sequence ID" value="XM_004363945.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNV2"/>
    <dbReference type="eggNOG" id="ENOG502TE0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNV2"/>
    <dbReference type="OrthoDB" id="10265086at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03786">
        <property type="entry name" value="GTB_UDP-GlcNAc_2-Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174:SF2">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-N-acetylglucosamine 2-epimerase" evidence="4">
        <location>
            <begin position="80"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="444" mass="48592" checksum="0C97043AA635DFE0" modified="2015-04-29" version="1">MSKQLLNIMNSSLLTPVPSIPTTPLSPSPSAAMLACGASYPNVAARIAERPTATRVLSIFGTRPEVIKFYPVLKEMDKRSESILSITCVTGQHRQMIDPLLSLFDIATDVDLNLMTQGQTLSNLSARLFLALAPVFEAVRPHLVLVQGDTTTAMIAAMCAFYYRVPVGHIEAGLRTNDRYNPFPEEVNRRIVSVVGNLHFAPSSYAADALRAERIDMNTVFVTGNPVIDAIMLIREKVPSAAARQLLDRVEAADAATNAVLPAGQKARHILLTAHRRENHGEGIAAICRAVKRIIAQHKDVHIWYPVHLNPAVCVPVRQELGKMERVHLLDPLEYDVFVHFLDRMYMVMTDSGGIQEEVTALAKPTIVLRETTERPEGVDAGVTKLVGINDDTIVKEATLLLTDDQTFAAMSRKCFPFGDGTAAQQIVDILLTSLSTNKLSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP59</accession>
    <name>A0A0D2WP59_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP59"/>
    <dbReference type="InParanoid" id="A0A0D2WP59"/>
    <dbReference type="OrthoDB" id="6149480at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027857">
        <property type="entry name" value="SCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31408">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC689986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31408:SF2">
        <property type="entry name" value="PROTEIN SPO16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15162">
        <property type="entry name" value="SCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="240" mass="26161" checksum="0228C5349E663AF6" modified="2015-04-29" version="1">MLSWNSLRSAEFVFIMQHSQQHPLHQQNFQALASAFMEQLQQQHHPLAHPLAVGYAPPAHSIIPSAPLHPPVPVLVHSAIANSDIMRELSVLLPSYVIRTSTALAPNVVVFPLSGAAFLLMSNPSMPLNAASVVEFADKFKSPYILVSVAHHDKSCLGRIEDVQAILGMRGASVVPVRTPAAIAKFMHTTATMLKQPACGVVAQRFQEYRALQFAQVAQIAWDVLKTIGLSHHDIGFVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP64</accession>
    <name>A0A0D2WP64_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363651.2">
        <property type="nucleotide sequence ID" value="XM_004363594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP64"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP64"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP64"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24036" checksum="C8B5AEEA341B19BA" modified="2015-04-29" version="1">MNQKQRELYDKVKNASGELGLQQNQIGDAEARAIAETLKVNTTLTKLYLDNNQIGDAGAQAIAKTLKVNTTLTSLSLGGNQIGDAGARAIAEALKVNTTLTVLYLDVNQIGDTGAQAMTEALKVNTTLTELYLDSNQMTDVGGQAIAEALKVNKTLTSLYLSQNFLTNTGITALNETGNTVCKLEDLDNQRAPSSADLAQIVAEVQQLRSKLAAQAPNWLPKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPU1</accession>
    <name>A0A0D2WPU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363411.1">
        <property type="nucleotide sequence ID" value="XM_004363354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPU1"/>
    <dbReference type="SMR" id="A0A0D2WPU1"/>
    <dbReference type="FunCoup" id="A0A0D2WPU1">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPU1"/>
    <dbReference type="eggNOG" id="ENOG502QURA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPU1"/>
    <dbReference type="OMA" id="VCLWNAQ"/>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040102">
        <property type="entry name" value="WDR41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805">
        <property type="entry name" value="WDR41-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25178">
        <property type="entry name" value="Beta-prop_WDR41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="48706" checksum="EC37F8AD4A0263A6" modified="2015-04-29" version="1">MLKSVRRAMGWAESEATPADASAIPEPVDEVQRNPFTDVQLLSGHTNIVRRLLRIDDTRFASAADDCTVIVWNYRTGRRLKTLVGHTLPINCILLLCVEADNTIIVTSSSDKTIRMWNIDRGDCVAVLKEHGGSAKCLVNLGNIQFCSGGKNVCLWNRQGQLLCSLARNEEDSDLTLMIRIRDNRMVCASSTKDLEVYYLDTQRSGNPRVVLVKKLTQHLETVRSLLNLSENLFASASLDGGIILWTTHTLVPVRVMNSHRDVQDVAHVYSYSVQHMIAVDERVLVAAVGHGFGMFDVLTGEALVKCFNAHLSTATQVMVLQDGARLLTCSADSSIRLWAPETENADDPNAVDSFVESGSQRGGAAQMKSVKAVCIGELVAHSDAVHALLLCNEHTFASCGADGMVILWKNGFVESRKRNELAKMMMLRQRAGAEGETLQEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPW6</accession>
    <name>A0A0D2WPW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348144.1">
        <property type="nucleotide sequence ID" value="XM_004348094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPW6"/>
    <dbReference type="FunCoup" id="A0A0D2WPW6">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPW6"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPW6"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="569" mass="60663" checksum="3E0D2C27025EC3D5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQH3</accession>
    <name>A0A0D2WQH3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347812.1">
        <property type="nucleotide sequence ID" value="XM_004347762.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQH3"/>
    <dbReference type="FunCoup" id="A0A0D2WQH3">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQH3"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQH3"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="372" mass="41892" checksum="302F0CDC34E21F12" modified="2015-04-29" version="1">MGPSHITEAAYVAQAPSSKAAGKRDPVPTLVSQATPTATARTRAASAASADETPAAPATAAAAPRTRRPDVYAKGLTAWAMPAFVGLLVAAGYALADMYQETISTFQYQQRITPLHAMWVPVTAVTCYAIGIFTLKRFVMDKRDKPVDGKFIQVLMFLHNGFLSAWSLVMLLKISTQIATTGYNAFVSETDTVNECLWCDSNKAQVQNNELYFWYHVFYISKFYEFIDTVFIVIRKKPLIFLHYYHHIITLLLCWVTMDDQLAPQWICIATNTLVHVFMYYFYMVQSAGFSVWWKRHLTKLQIIQFVADQIGNHMWVYYAWIVKLACPGSVVGYAWGTGVIGSFLVLFLQFYARTYKRPAAGDKRGTPVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR91</accession>
    <name>A0A0D2WR91_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348250.1">
        <property type="nucleotide sequence ID" value="XM_004348200.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR91"/>
    <dbReference type="FunCoup" id="A0A0D2WR91">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR91"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR91"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR91"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="210" mass="23372" checksum="AAE4D862BC5FD22C" modified="2015-04-29" version="1">MSTSSLARGALIVFEGCDRSGKSTQCLMLVERLKALGKRVQHLRFPDRSTPTGQKINAYLANASEMQDDKIHQLFSENRWEAVPSMLEALKNGTTLVVDRYAFSGVAFSSAKGLDLEWCKKPDAGLPAPDAVIYLDIPIEAAMKRGDFGNERYETRAFQEKVAAQYKKLQTPSWMMMDARLPIDQLQADIFNIASKVIADAQNAPVGKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRP3</accession>
    <name>A0A0D2WRP3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein RAD54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRP3"/>
    <dbReference type="FunCoup" id="A0A0D2WRP3">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRP3"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRP3"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRP3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="352"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="687"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="900"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111762" checksum="8473C93C46DA1527" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT92</accession>
    <name>A0A0D2WT92_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345618.1">
        <property type="nucleotide sequence ID" value="XM_004345568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT92"/>
    <dbReference type="InParanoid" id="A0A0D2WT92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="148" mass="15537" checksum="8BCECD6D8C3DBF9D" modified="2015-04-29" version="1">MVRILNGEIVQDNDPRLQQSTRSPSSSSSSSSSASSGSSRVASIHSTPTPSSASSSRGDRRQPQDQNQPAQPQQQQPERRSSLGDLLLPGGYLYAANMSVKQYIPAVQLGGGIVVEPLLLAIVAVSFLVDLKFGVAALLLAFVVATGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVL4</accession>
    <name>A0A0D2WVL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 17">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_006621</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 17"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344242.1">
        <property type="nucleotide sequence ID" value="XM_004344192.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVL4"/>
    <dbReference type="FunCoup" id="A0A0D2WVL4">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVL4"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVL4"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE96278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="216" mass="24383" checksum="C385E71093B16575" modified="2015-04-29" version="1">MAENIFLFVPNLIGYARVIFALIAFYLMPTDPTPAIFCYLLSGLLDAFDGHAARALNQSTKFGAVLDMVTDRCATAMLCVTLAVLYPAYAFFFQFMIGLDIGSHWIHMYSSLTNNKSHKVIDPKKNWFLRLYYTSRTVLFLMCAGNELFFGSLYILYFFEGPIVPGVAIGVWRLILYICAPVSFVKNVISIIQMLEACHDLAEIDVKARQDARKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVV6</accession>
    <name>A0A0D2WVV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SERF family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343381.1">
        <property type="nucleotide sequence ID" value="XM_004343331.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVV6"/>
    <dbReference type="InParanoid" id="A0A0D2WVV6"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040211">
        <property type="entry name" value="SERF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596:SF0">
        <property type="entry name" value="SI:CH211-39K3.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596">
        <property type="entry name" value="SMALL EDRK-RICH FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="64" mass="7105" checksum="A2BFD124DDA0BFEE" modified="2015-04-29" version="1">MTRGNQRDINRDRTVKANKEKSKSIPISQKGDNVGLTHSQRMERDAQALRDKAAKKAAAAEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX10</accession>
    <name>A0A0D2WX10_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270771.1">
        <property type="nucleotide sequence ID" value="XM_011272469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX10"/>
    <dbReference type="InParanoid" id="A0A0D2WX10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43019" checksum="0D30EF1DCDF7C783" modified="2015-04-29" version="1">MSWTRSDASSHSAMLSSSSSDIGAVCIELRPTALTTPENETDWASIAQQQPNQDLQQLEQQSSGDATELEVLQFPSSNSSANSNAADRLKAAGAGAGAEPTAATESADRKQPTIKAKQVPPRVLALATPRVRRMLKLRTRIRFVSFVLFAVLGKTLLLSLVLPFWGETSISQTRNVTAAPPTPSTPGTFNVHVDVSDKNVGLLFEYSDFGHRATFPQWPFGLSAFLMCVSIVLLMATGLVLEHCRRCILEGQRVLGYHTAAAILPLFQILAQLGAFYIFGRYGMPREMDDGTANYQWDSTVWGGSIYELFVIMAMEGLQCITHLNLRLVVGQIPGEVLKYEDELDSKEKAEEGEADDSGDRLSAPRSTSALMAESMREDASRSSTEQDAWPSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX52</accession>
    <name>A0A0D2WX52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOCA HR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342860.1">
        <property type="nucleotide sequence ID" value="XM_004342811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX52"/>
    <dbReference type="InParanoid" id="A0A0D2WX52"/>
    <dbReference type="OMA" id="NIPIMGS"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="TOCA HR1" evidence="4">
        <location>
            <begin position="385"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="939" mass="97748" checksum="7655019B4D1C5DE7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXA1</accession>
    <name>A0A0D2WXA1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343108.1">
        <property type="nucleotide sequence ID" value="XM_004343058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXA1"/>
    <dbReference type="STRING" id="595528.A0A0D2WXA1"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXA1"/>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF173">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDRATASE-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="319" mass="33521" checksum="7A523D836111ACDC" modified="2015-04-29" version="1">MLLQSGLRLGHSIVRFASTTAAAATTSASASTATRAAMITVTRDSLPADKDGKPGASTGVAIVAFNTPHNLNAFTAELGQQFEATMSKLAVDPTLRAVVLTGNGRAFSGGGDLQFLLDRSKETAMNNAFIMKAFYRRFLSIRKVPVPTIAAINGPAVGAGFCVALACDLRLAATDAKMGVNFVKIGITPGMAGTHILPAISNPQIAARLCLTGDLISGAEAKELGLVTSVEQPDQLVPRALDLARRIANNSPRATRRLVMMLRGRVDQGLEQALWTEADAQASCYSEPDLIEGINAVKEKRAPKFVDFGAPLMPGGSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY22</accession>
    <name>A0A0D2WY22_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiopurine S-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342424.1">
        <property type="nucleotide sequence ID" value="XM_004342375.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY22"/>
    <dbReference type="STRING" id="595528.A0A0D2WY22"/>
    <dbReference type="eggNOG" id="ENOG502QSF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY22"/>
    <dbReference type="OMA" id="LWCGDFF"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29502" checksum="2B677033775788BB" modified="2015-04-29" version="1">MNFTPSEGIAIASPAFWSERWVKHEIGWHIPTANPVLVEYLPKLIGQPYPAVDEHDGTPQALLQARTKALAEYVRPAPSQAGFLLPLCGKTIDLVFLARLGFRVVGIEIVEQAIQEFFQENNIPFKTEQHVLHETKESVKVHTSTDPNMNISIFQADLFAVTSKDVGALHFSFDRGSFVAMQPALRTKYAVTMTRILAPTARILAAMIDYEEGVMAGPPFNVTNAAIEQAFSPVGSQIEYVEVKSNKTRFSFEMLERIVIIAMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYG4</accession>
    <name>A0A0D2WYG4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carnitine/acylcarnitine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYG4"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYG4"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="362"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="463" mass="48129" checksum="1086C35721A0F846" modified="2015-04-29" version="1">MAEAPTSFGLGEVGKDFIAGTFAGCAGILTGHPFDTIKVRLQTQTHTPGTQLRYSGTIHCFVKIVREEKIRGLYKGMASPMAGVALINAMLFGVYGNSVRLLEGSGSAEPARRPSIQTVFIAGAASGLVNSFASCPIELVKTRLQIQMDSAVATNSGSSSLPSATPPATTITTTAAAPTAASGTGPTTHALAGSAPKTTAGAMATSAVPHRALHSFSVFSSSSPSSVPLSSALASFKAATSSPAPSGTTSSTSVIWSAVRRRLPLSRSLSTSATTKATATITPSATGAAAATAAATAEPLYKGPWDCFVRTVRQDGIRGIYRGLVPTMLRETPSYGVYFAAYEMLCLRLAGPGRSPDDLSAPALMLAGGASGMAGWLSTYPTDVVKSRMQADSMTNPQYRGFVDCVVKSYRAEGLGVFFRGFNATMVRAFPTNASTFVVYTMCMRLLGGVDTSQDHSHTRHME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYS6</accession>
    <name>A0A0D2WYS6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270896.1">
        <property type="nucleotide sequence ID" value="XM_011272594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYS6"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYS6"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYS6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF117">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="263"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="901" mass="95864" checksum="2D78DF3A4E949766" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYU1</accession>
    <name>A0A0D2WYU1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342491.1">
        <property type="nucleotide sequence ID" value="XM_004342442.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYU1"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYU1"/>
    <dbReference type="OMA" id="CAMISST"/>
    <dbReference type="OrthoDB" id="552574at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="918"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2071"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1981"/>
            <end position="1991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2099" mass="215178" checksum="AE3E9EBA266D4905" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYX8</accession>
    <name>A0A0D2WYX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008297</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346390">
        <property type="protein sequence ID" value="KJE98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYX8"/>
    <dbReference type="STRING" id="595528.A0A0D2WYX8"/>
    <dbReference type="InParanoid" id="A0A0D2WYX8"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="16">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="606"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="905" mass="94721" checksum="277FB3245E277736" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X039</accession>
    <name>A0A0D2X039_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_000051</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364922.2">
        <property type="nucleotide sequence ID" value="XM_004364865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X039"/>
    <dbReference type="eggNOG" id="ENOG502QS20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X039"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X039"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="454"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="790" mass="86553" checksum="7FE8DA384EAA2E32" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0A8</accession>
    <name>A0A0D2X0A8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365198.1">
        <property type="nucleotide sequence ID" value="XM_004365141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0A8"/>
    <dbReference type="STRING" id="595528.A0A0D2X0A8"/>
    <dbReference type="eggNOG" id="KOG0126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0A8"/>
    <dbReference type="OMA" id="RHDEKHS"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0A8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="293" mass="33075" checksum="781BE4C948CBDCD0" modified="2015-04-29" version="1">MNTVRQIQRVNERELQRGLTASQSSSASWHDEFRGSAYVHVGGFPYELTEGDLLCVMSQYGEIVDINLVRDKKTNKSLGYCFIAYEDQRSTVLAVDNLNGIKIGNRTIRVDHVKDYRLTKDLQEAEPLLPGQTPLEAAMQAAAKRAPNDSSSSSAVVPPSASSSSATTSNDKLDDYRSPARISSDDDGTLDRKERKHHKEHKEHKHHKHHKEHKHHKHHKEHREHKEHKEHREDRERRRHDDDDDRYSRDDKRIRLADDVDSSASRPVIGASSAISASAAAVAAMFAASGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U0</accession>
    <name>A0A0D2X0U0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365952.1">
        <property type="nucleotide sequence ID" value="XM_004365895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U0"/>
    <dbReference type="STRING" id="595528.A0A0D2X0U0"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0U0"/>
    <dbReference type="OMA" id="VEPHMKR"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="175"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="31055" checksum="03CC333A53AE579D" modified="2015-04-29" version="1">MTGRAQSQLLHASVVAMLTISRRVVGRTLSRCWAPLPTATRDAKSHGTRLCIIDSRCVSTLSGPVIRRSQHNPQLVDLTRAGPTFHPEGLVVIPDAISQEEHDALVEDVRGPLRRMRLELNHFDSVIRGYKEITFSKWALPGSQTVIARVLASDLFAPGTQLHPNQHVLELAPSGYIAPHIDNVEACGEYVAGISLLSASVMRFTYKDEEVRILLEPRSIYCMSHAMRYKFKHSIVCNSSPPEIFGSRSIVRDRRISVLFRDQPKPVPPEMMSDETDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X170</accession>
    <name>A0A0D2X170_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008531</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X170"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X170"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X170"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266730" evidence="14">
        <location>
            <begin position="29"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1054"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE90294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1344" mass="141852" checksum="8CADB8158C3D3F18" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1L7</accession>
    <name>A0A0D2X1L7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1L7"/>
    <dbReference type="InParanoid" id="A0A0D2X1L7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13922" checksum="10FC4C460B13738C" modified="2015-04-29" version="1">MLTNLLSLSVFSRLALRQSWLQSKKVSSLGSPIVLFVSFSFAFVHCVQFDLVLPDLSRLSPCSLPATPFFSFLLFFALVRIALPSTATQDPPTRQVSRSQGDKHPASPISGLFGSIQEGENTTTHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1M6</accession>
    <name>A0A0D2X1M6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 7 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349016.1">
        <property type="nucleotide sequence ID" value="XM_004348966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1M6"/>
    <dbReference type="STRING" id="595528.A0A0D2X1M6"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1M6"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="5">
        <location>
            <begin position="110"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="915"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1116" mass="118552" checksum="5CCDAD9280E2A7D9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X233</accession>
    <name>A0A0D2X233_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363767.2">
        <property type="nucleotide sequence ID" value="XM_004363710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X233"/>
    <dbReference type="STRING" id="595528.A0A0D2X233"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X233"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X233"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53603" checksum="98AA7BDEC0301D10" modified="2015-04-29" version="1">MLSYESMTERQRELYDKVKNTSGWLDLYDNQIDEAEAQAIAEALKVNKTVTALWLKNNQIDDAAANTIAEALKVTKTLSELYLSHNQIGHAGAQAIAEALKGNKTVTELNMNGNQIGDGEAQVIAEMLKVNTTPTTLILANNHFGCAGARAIAEALKMNKTLIELVLGGNQIGDAGAQAIAEALRVNKTLTRLGLDKNQIGDAGAKAIAEALQVNKTLPWLNLIDNQIGDAGAQAIAEALKGNMPVQTLYLDWNRIDDAGAQEIAGALKVNTTLKWLDLRSNCIGNAGLQAIREASQVNRTLSNLCIHSQINPLAFSLLPRLATADDLQTVLHLLTCEPVLEDQATSLPALPTELAELIMDKAHYWQGVHRTKRWEFDDYTTNILKVTLPQGLNGNSVRVKAIQVLRDTRNRSDSIDDTGFDLVVRDEQGAIRYECSAAPTFVDSFFELVTILPANHPVIRQMRAGWQVQVRPNMSLTAVLLERLDVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2D5</accession>
    <name>A0A0D2X2D5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2D5"/>
    <dbReference type="STRING" id="595528.A0A0D2X2D5"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2D5"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2D5"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="337"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="592" mass="63053" checksum="251C4EA200965CA6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2L5</accession>
    <name>A0A0D2X2L5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2L5"/>
    <dbReference type="InParanoid" id="A0A0D2X2L5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="12877" checksum="8835AFFACD278934" modified="2015-04-29" version="1">MRLDEFGWGCGRGRGKEAEMRKIKKKGKESKLFAQRTTSHCSVQTKTTIHGRRDREGGLEKRGRGGEKREDADAISARFRRVRVRRVIEFDAEGLRESPFTVTVIIITTITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q9</accession>
    <name>A0A0D2X2Q9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q9"/>
    <dbReference type="eggNOG" id="KOG1667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q9"/>
    <dbReference type="OrthoDB" id="9949485at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="69" mass="7280" checksum="76E60DFAEFC481A7" modified="2015-04-29" version="1">MSSGSGLYIPADTLAGLEKLAAVADALTANVIQLNEEMERILDGKADADTLVTILNQHAALYKPPEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2W6</accession>
    <name>A0A0D2X2W6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004086</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2W6"/>
    <dbReference type="STRING" id="595528.A0A0D2X2W6"/>
    <dbReference type="eggNOG" id="KOG1226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2W6"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2W6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057709">
        <property type="entry name" value="DUF7949"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25820">
        <property type="entry name" value="DUF7949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="16">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="15">
        <location>
            <begin position="46"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="16">
        <location>
            <begin position="634"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="762"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="830" mass="87694" checksum="DABB48BB5DAD848D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X371</accession>
    <name>A0A0D2X371_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347289.1">
        <property type="nucleotide sequence ID" value="XM_004347239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X371"/>
    <dbReference type="STRING" id="595528.A0A0D2X371"/>
    <dbReference type="InParanoid" id="A0A0D2X371"/>
    <dbReference type="OMA" id="HNEITAC"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="551" mass="58645" checksum="207F42812C512E9B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3L1</accession>
    <name>A0A0D2X3L1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-24</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CAOG_005133</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="27">Interacts with ZFYVE20. Does not interact with the GDP dissociation inhibitors ARHGDIA and ARHGDIB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346818.1">
        <property type="nucleotide sequence ID" value="XM_004346768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3L1"/>
    <dbReference type="STRING" id="595528.A0A0D2X3L1"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3L1"/>
    <dbReference type="OMA" id="NCDEHCK"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000799">
        <property type="entry name" value="ras-related protein Rab-24 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00093319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00093500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KJE94499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="22844" checksum="475B3B61CE1FFFC2" modified="2015-04-29" version="1">MTAKVDLKVVLLGREASGKTCLVDRYLHDRFNFGVNQATVGAAFGAKKLQIGGHTITMGIWDTAGSERYEAMSRIYYRGAKAAITCFDVMDPTSFERLKFWVNELRNNEEHCKLYICGTKVDIAEGNRSGRVDVHSVSDYADEVHARYFDTSSKTGQGIQELFTAIAEDFIQSESKTRTLAADGATVPLARRDPVGSGRSAEPAGGCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3R5</accession>
    <name>A0A0D2X3R5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5898 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3R5"/>
    <dbReference type="InParanoid" id="A0A0D2X3R5"/>
    <dbReference type="OrthoDB" id="20660at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3R5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045417">
        <property type="entry name" value="DUF5898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871:SF1">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19250">
        <property type="entry name" value="DUF5898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5898" evidence="2">
        <location>
            <begin position="568"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="747" mass="82142" checksum="FCE40ECF9B9D532C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X479</accession>
    <name>A0A0D2X479_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X479"/>
    <dbReference type="InParanoid" id="A0A0D2X479"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="78" mass="8696" checksum="CDAE48E44151776E" modified="2015-04-29" version="1">MYVGVQFLANFDRQAPAEGVNPGDSRFHPTATMGFCGFSAGVDLGVRYFMLRYTNPRWAIVSTKPNNAQLRFQQGAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X487</accession>
    <name>A0A0D2X487_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345653.2">
        <property type="nucleotide sequence ID" value="XM_004345603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X487"/>
    <dbReference type="STRING" id="595528.A0A0D2X487"/>
    <dbReference type="InParanoid" id="A0A0D2X487"/>
    <dbReference type="OrthoDB" id="8065870at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="46268" checksum="FD6D0277B5DC56FB" modified="2015-04-29" version="1">MFECSICLCALESEASVAVVCGHVFHRSCIVEWFGTSNSCPTCRIAVRSQKALVRLFFAGNRGEPTSESDGARAAEAGYQALMRDLGDEEEAPPSAKIQQELQQLRARRDHDARVLAESQVSIERQRILLEAAANQARGLLARVNDAESIRATLSLRLANMQSLERENALLQSRAQQSEKQLEQLKREHLAISACVSFRDADPEKVQAKLNNFRSHPNAVEELIKMQDWMSKEFRKQKDLLSDTHAKLQEKTSLYEQLEIEANKHRRDANEAQLAAARLTDDCQALENELAELRGRLKSASRMVVSSPPVLATRESNSNFIDLDADPVVVSLPHPTTTPKIARHAFTPADRVDSKRPRLASSSASSNETFDASFFNQPRRALGAASFLPSFGNKQRLAYTKGFDGLGGRSTVQRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4K2</accession>
    <name>A0A0D2X4K2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345310.1">
        <property type="nucleotide sequence ID" value="XM_004345260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4K2"/>
    <dbReference type="InParanoid" id="A0A0D2X4K2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="371" mass="38988" checksum="9D79E39EEEBDDEC3" modified="2015-04-29" version="1">MSLSSSSSSSTSKTPLLDLTGSWTSASLASSLIADTPNVETSPGSSSLSSLSNSRSGLDSSASSSSQPVLLLDRAADLVHSDQSTADSEVSDHEYLLPAADSSDDDHDDHDGSNSDQPKSLSSSLSSSWSRLGRSFTDSGAASASASITGGQANGGGVTAPVEVAAAARVAQTPPAPSQTEQPVVTDATPASVQTMQPKSHKRLRRSVNQTGRSPFKTQPQLQQPQQHGSRRASKRHTCNGCRCLAYIVAVILAGLVLWLIYDLTATNAALSDQLRQMTDTVEELRSRLSSTEQRLSGITEQLSSSPSVHFSTNLWSSVVDRTTSTFNTVKDQLASTVEHAGKRFGFGDKPSSLSKSPPKAKTQRQPAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4P3</accession>
    <name>A0A0D2X4P3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344363.1">
        <property type="nucleotide sequence ID" value="XM_004344313.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4P3"/>
    <dbReference type="FunCoup" id="A0A0D2X4P3">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4P3"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4P3"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4P3"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="374" mass="41205" checksum="5CD3A5401C90B6B6" modified="2015-04-29" version="1">MHFLQSVTAAALRFPARPVGVSAMLYRRMGSTAASTAASIEPYSPGRLAKQVAARHPTKHTLFVAKTVAEMRQARHELRQVQFQQQQQEGGSSPPATSHTTEVGFVPTMGCLHQGHLSLMRQAKKDSRAVVASIFVNPSQFAANEDFDKYPRQDKDDLAMCAKEGVDLVFLPEVAEMYHGSTGTDAFGKVGTFVEVRGKSQLLEGSVRPHFFLGVATVVSKLFNIVQPTTAFFGQKDVQQCVILRQMVHDLFMPLNIRVCPTVREKDGLAMSSRNVYLSPEERAIAPIMYRGMQAALNEHYLKRGERSAAALREVVRQVIATEPSVTIQYISIADGNSLQEVDTIDDKNGAILSGAIKVGKTRLIDNILLDFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5H1</accession>
    <name>A0A0D2X5H1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342980.1">
        <property type="nucleotide sequence ID" value="XM_004342930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5H1"/>
    <dbReference type="InParanoid" id="A0A0D2X5H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="42804" checksum="6C7368D17FA807B3" modified="2015-04-29" version="1">MNHQAFGHMGSISGPAVPGSEHLAMSANGPVLARIAANFSMSPTTEEQLRQMSLACKLTTTQPNQPSQKPLVVLRRIAAKPQSPTPVSEPTQETTTTKRRGPNGFIVFRTMNKHRYSHLPSRASSIELGKLWKQLSSDERVTFEMEAQKRELLQLNTNKPARATKVRKPRLLYNNRLTAAGRRQAQQVAESCLPRSFLAHETLHADHEMFPLDVTDASSLFPGSKACEPPILPISSSNSSTFSSTTSAALSLASDSSSTLAEPSPISDSDSSCSVVDDWRNTNLEAPLHPRPFVRLLGLSGQDDDCENISSWLSPPAESAPLPILPAPHPKNLACQLAQRATFVVSACHSPTLVCQSPVPLPPPSIAIDMSWLDWAERDLAVRSVDSNQSSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>E9CJL8</accession>
    <accession>E9CHT7</accession>
    <name>E9CJL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341667.1">
        <property type="nucleotide sequence ID" value="XM_004341619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343247.2">
        <property type="nucleotide sequence ID" value="XM_004343197.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CJL8"/>
    <dbReference type="InParanoid" id="E9CJL8"/>
    <dbReference type="OMA" id="IEDMFDQ"/>
    <dbReference type="PhylomeDB" id="E9CJL8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="185" mass="21188" checksum="B172FB903C0D1E53" modified="2011-04-05" version="1">MAMQTRAVENDLVGVILDDHQHLLELFREFDCEKAKSKRKTDMAKHIIKQLALHDWLEVQFLYPTMQKIDCTATHHALDAHMEAETLIEQLLSGDMDPESEAFREQMSTLITDVRRHMMDEEFNILPQLRKHFTVTELVNRGELWEKAKACAPQNPRLAPALSLHQGITAAQLDLNPAADELSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0J8</accession>
    <name>A0A0D2U0J8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory factor X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365227.2">
        <property type="nucleotide sequence ID" value="XM_004365170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0J8"/>
    <dbReference type="STRING" id="595528.A0A0D2U0J8"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0J8"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0J8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133996" checksum="421C078FAD8D798D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4J1</accession>
    <name>A0A0D2U4J1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364309.1">
        <property type="nucleotide sequence ID" value="XM_004364252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4J1"/>
    <dbReference type="FunCoup" id="A0A0D2U4J1">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4J1"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4J1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4J1"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="602" mass="66863" checksum="C11901229B2E8F6F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6Z5</accession>
    <name>A0A0D2U6Z5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348908.1">
        <property type="nucleotide sequence ID" value="XM_004348858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6Z5"/>
    <dbReference type="STRING" id="595528.A0A0D2U6Z5"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6Z5"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RBD" evidence="6">
        <location>
            <begin position="415"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="514"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="686"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="930" mass="103944" checksum="456EBF6D3A8467BE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7R9</accession>
    <name>A0A0D2U7R9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease P/MRP 30 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349060.2">
        <property type="nucleotide sequence ID" value="XM_004349010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7R9"/>
    <dbReference type="STRING" id="595528.A0A0D2U7R9"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7R9"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7R9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="361" mass="38995" checksum="4FA8417242442CD3" modified="2015-04-29" version="1">MFVDLCVSAPATQSDRLQFRQHLTSFGYGAVAYNQRFAGRIAVGKNVPPPPFVPAAADGVHAPSSSSSTPTSNAAAAAAASNIASSRTRWTAAIADRLKQTPTSSMLELSRLTVVIADQQDWAGYCTNYQQVLKNYDILAVQPETEKLLQQCLQSSEVDIITLDMSKRTPFFIKHSMARVALEQGIVFELLYTDAIRNSESRRSLILNALSLIRATKGRNVILSSGAQKPIELRSPYDVMNLGLLFGLTHERSRNCLTSLPRGVLYHAETRLTTGLSAVRITPLAATAAKADKAGSKNAPSSNAAATMKPLANTTAAKGKRPIRSTSASGDDDDDEDEDEDVSDDEDDDDDDDTDQTPMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7Y6</accession>
    <name>A0A0D2U7Y6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RapGAP/RanGAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349116.1">
        <property type="nucleotide sequence ID" value="XM_004349066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7Y6"/>
    <dbReference type="STRING" id="595528.A0A0D2U7Y6"/>
    <dbReference type="eggNOG" id="KOG3686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7Y6"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="416"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="828"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="890"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1051" mass="111561" checksum="432B0B89FD8C6932" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8J2</accession>
    <name>A0A0D2U8J2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2U8J2">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U8J2"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8J2"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8J2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="572"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="791"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1420"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1687" mass="185312" checksum="7122217A9ED19BC3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAL1</accession>
    <name>A0A0D2UAL1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270275.1">
        <property type="nucleotide sequence ID" value="XM_011271973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAL1"/>
    <dbReference type="STRING" id="595528.A0A0D2UAL1"/>
    <dbReference type="eggNOG" id="KOG3569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAL1"/>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAL1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="40"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="933" mass="99780" checksum="93EC73F4DC264983" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDT0</accession>
    <name>A0A0D2UDT0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDT0"/>
    <dbReference type="FunCoup" id="A0A0D2UDT0">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDT0"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDT0"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="24084" checksum="C7422A411BA90EC1" modified="2015-04-29" version="1">MTFYWSSSVTILFDEWAPATMGEYFGALVAVFFLGVAYELTRFLAHSLDKSLLAQSARASNDHSVLIEKRHVNGSGSSRVNFGLFDQLKRALLHMIQLTLAYLLMLVVMTYNGGLFIAAIVGSGVARSWIQARRSATNDPIPLAASHEAALDLSTSDLGGDRCHTDPDESSMTLATTPVQPSVAGIRTLSVTRAYQPLRDQSDHLDDLASGGDDDLFAATSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDU3</accession>
    <name>A0A0D2UDU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347885.1">
        <property type="nucleotide sequence ID" value="XM_004347835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDU3"/>
    <dbReference type="FunCoup" id="A0A0D2UDU3">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDU3"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDU3"/>
    <dbReference type="OMA" id="RTEVAYM"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="3">
        <location>
            <begin position="390"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="570" mass="62097" checksum="A87700DDB3C750BA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE44</accession>
    <name>A0A0D2UE44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_004184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348009.1">
        <property type="nucleotide sequence ID" value="XM_004347959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE44"/>
    <dbReference type="FunCoup" id="A0A0D2UE44">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UE44"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE44"/>
    <dbReference type="OMA" id="RIAFAFS"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253341" description="Ergosterol biosynthetic protein 28" evidence="14">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14544" checksum="166D0E188CA1586A" modified="2015-04-29" version="1">MFLTALRAWLGLVGSIAIVNGATCFVDATYPSRMLYTANPTQVTPLASRLFGVWTLLAGALRVASAINTADTTLYVLTIISFVLANVHFVSEIWVYRTAKITGKTISPLVVSGVSILWMLVAYSDAANSYKSIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE70</accession>
    <name>A0A0D2UE70_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348039.1">
        <property type="nucleotide sequence ID" value="XM_004347989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE70"/>
    <dbReference type="STRING" id="595528.A0A0D2UE70"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE70"/>
    <dbReference type="OMA" id="GDRAKHD"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="154" mass="17187" checksum="AD0464464CF403F5" modified="2015-04-29" version="1">MAANAQSRVIKRIQKELAEVTLDPPCNCSAGPKGDNLLEWTATILGPSGSPYQGGVFFLEIFFSADYPFKPPKVVFKTRIYHCNIHASGSICLDTLKDQWSPALTISKVLLSICSLLTDPNPDDPLVPAIAHEYLKDRQLHDKTARDWTRRYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEF1</accession>
    <name>A0A0D2UEF1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEF1"/>
    <dbReference type="STRING" id="595528.A0A0D2UEF1"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEF1"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEF1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41357" checksum="8469DFD8DF8AA1DE" modified="2015-04-29" version="1">MERTVDGVIVLDYADLLSGADLSAQIEAAFGDGPDALGALFVKNVPDYQSRRLQLLPFASKYAALPDTIKATRLSFVLTRACCLGPSFSLPDTQQAKTTHPESSFSFGWSHGKEKFDGKLDVAKGSYYANPQYDVPTTDPELIKSLPELCSNNIWPEEDCPGFGDAFKNLGRLIVSVGELLGKQCDSYAERHLPGHKAHIYESIARSRTCKGRVLHYFPQASAAIPAAAAGAGDDSQYASWCGWHLDNSALTGLTRAMYLDPQHNEVECPDPDAGLYIRSRSGKVVRVSIPADMLAFQMGESTQIRSGGKLRATPHCVRGAMGEKAVGISRNTFAVFMQPHWDETLDAPAGATVEDVAVPQWKAGMTFGEFLKSVFTYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF71</accession>
    <name>A0A0D2UF71_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UF71"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF71"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF71"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037517">
        <property type="entry name" value="HDAG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51838">
        <property type="entry name" value="HDAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDAg" evidence="8">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1531"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="736"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1269"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1588"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1757" mass="196552" checksum="57453B284BE212D6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF83</accession>
    <name>A0A0D2UF83_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF83"/>
    <dbReference type="InParanoid" id="A0A0D2UF83"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF33">
        <property type="entry name" value="BLL7664 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252578" description="SET domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="660"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1280" mass="140074" checksum="BDBF9761BA12220D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHS3</accession>
    <name>A0A0D2UHS3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346934.2">
        <property type="nucleotide sequence ID" value="XM_004346884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHS3"/>
    <dbReference type="InParanoid" id="A0A0D2UHS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="194" mass="20114" checksum="C9141FE920B72CB9" modified="2015-04-29" version="1">MAKSSRRSNDGANSTNASRASSHARSAAGAGAGASSSPSSSSSGASGASGRVGAGSGTRVAATTKPAKTVAAAKQDSAPARLAHRRKGAAAVTSSDDDDEDLEDRDDDEDEDEDEEDDERAYELPSVVASSQRLEQLSRTLHHLKESSDQHLAGSWRHHSWAHMLGMLVLVIVVACVIAGILDFMDADLSALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJL0</accession>
    <name>A0A0D2UJL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346432.1">
        <property type="nucleotide sequence ID" value="XM_004346382.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJL0"/>
    <dbReference type="STRING" id="595528.A0A0D2UJL0"/>
    <dbReference type="eggNOG" id="KOG3673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJL0"/>
    <dbReference type="OMA" id="HFTIQTH"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="4">
        <location>
            <begin position="257"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="840" mass="93443" checksum="2958375D1A7BAA5F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULH0</accession>
    <name>A0A0D2ULH0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid/polyisoprenoid-binding YceI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345088.1">
        <property type="nucleotide sequence ID" value="XM_004345038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULH0"/>
    <dbReference type="InParanoid" id="A0A0D2ULH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252904" description="Lipid/polyisoprenoid-binding YceI-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19769" checksum="A048904D3FDC45E4" modified="2015-04-29" version="1">MRSSVIFTVAILAALVVASGSVAHGQKLVPKYFTLLFRGSIQNATTDPIHAAATTTKFQTSIDPNLGFVTTVQSLPGPLAVWDATIFDYKQNPDFSATFRENGTISFGLHDAKPHVLHVEGEGAFRPVTSTSFVGTGAWRIVSGEGQFAGATGFLSATWFGEIDPKDPTRLDTENTVTGNFFVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMM7</accession>
    <name>A0A0D2UMM7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">p22-phox</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p22phox family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344260.1">
        <property type="nucleotide sequence ID" value="XM_004344210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMM7"/>
    <dbReference type="STRING" id="595528.A0A0D2UMM7"/>
    <dbReference type="eggNOG" id="ENOG502QVK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMM7"/>
    <dbReference type="OMA" id="WINIFIG"/>
    <dbReference type="OrthoDB" id="2445232at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMM7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007732">
        <property type="entry name" value="Cyt_b558_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168:SF0">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05038">
        <property type="entry name" value="Cytochrom_B558a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="186" mass="21024" checksum="F2BF6FE5AD9D2FFF" modified="2015-04-29" version="1">MGKIEWCMWANQQALASATIMFICGVISTYYPKKEYGYYAIAASVAITLLEYPRGKRQRGTTPERPYQQYLAKAITAMRFVGRNYYVRFALYVGLSIPCFFQMPTVLCGAYLDITALVYLRAGLAGEQWVDPRSTVKPKDKKEKEAVQRPKESLPMTEIPAAPNRLPPKPNKPPPMPNKPPRDVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMQ5</accession>
    <name>A0A0D2UMQ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KIN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMQ5"/>
    <dbReference type="STRING" id="595528.A0A0D2UMQ5"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMQ5"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13155">
        <property type="entry name" value="KOW_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000092">
        <property type="entry name" value="DNA/RNA-binding protein KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000021">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041995">
        <property type="entry name" value="KOW_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="486" mass="54366" checksum="A403905F6E1A2362" modified="2015-04-29" version="1">MTGYSVEFRRLWKATPVLLYPTPTSSSQTPLPRPKAMTKAEKGSPKDIANRIKAKGLQRLRWYCQMCQKQCRDENGFKCHTLTDGHKRMMQVFSDNSSSILDNYSRDFEKTVLEMVARRFGTKRVLANVVYNEYIQDRHHVHMNATIWETLTDFVMYLGKTNKCNIDHTERGWYIAYIDRSPEALRRAEEAERKEKMEMDDEDRSQRHIEKQMQRARELADAAQAKRESEIAANPDSTSAEPAEIDPEKLKFSFAPIAAPAAKTASLSELLKGGSSDASSRNGASSASSFSNVFATSDSSSSSRKESSNGSSSSSSSSSGAQKRKISALDEIMAAEQEAKQHNKSARIENWIVVGLVVRIINKSLSNGQYYKQKGIVVAVSNKFVADVQVLDSDDVLRLDQEHLETVLPALDQSVYIVNGQYRGGIARMLELIPDKYRARVRIESGSNSGRTIEADYEDVCKFDPTVLLRSTSSSSSSHSSSSRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT28</accession>
    <name>A0A0D2UT28_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT28"/>
    <dbReference type="InParanoid" id="A0A0D2UT28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="173" mass="19608" checksum="5F54B77D817CA49C" modified="2015-04-29" version="1">MYEHKTDKSLLPFECFRNSSLESPFFVRLIPRENDLPIVHPRLGGLRLSGTHVQNLFLTEYGRGDKEAVWRISGNVNSLALTVLAVDGKPKYVTYTARERVDRGAAGSARRNRVIRLVHEIISPDHSDEPLLMLVLCINNLETEIVGHPAGVALNALTRWIQRNRNARRSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTS7</accession>
    <name>A0A0D2UTS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346414">
        <property type="protein sequence ID" value="KJE98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004340774.1">
        <property type="nucleotide sequence ID" value="XM_004340726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTS7"/>
    <dbReference type="STRING" id="595528.A0A0D2UTS7"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTS7"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="3">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="142" mass="15072" checksum="CA51C7821F0A8539" modified="2015-04-29" version="1">MQVTDDGGDRSANDDHGGNATPAKSSSNATPANSSFSSSSSSSFSSSAATAAADRKPAKHDADDDDDDDDDCSMLAAARRHTRQQLKADQNALGSSCPYLDTVDRSQLDFDFEKVCSVSLSDFNIYACLICGKYFQGKLPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH15</accession>
    <name>A0A0D2VH15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH15"/>
    <dbReference type="STRING" id="595528.A0A0D2VH15"/>
    <dbReference type="eggNOG" id="KOG3982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH15"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="966" mass="102614" checksum="C8A30C6F347EF016" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI40</accession>
    <name>A0A0D2VI40_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365903.1">
        <property type="nucleotide sequence ID" value="XM_004365846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI40"/>
    <dbReference type="FunCoup" id="A0A0D2VI40">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI40"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI40"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI40"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="263" mass="29499" checksum="ABBEF1B6CE1FDE8B" modified="2015-04-29" version="1">MVVGSKKHLKRLAAPKHWMLDKLTGTWAPRPSTGPHKLRECLPLIVFLRNRLKYALTHQEVKFILAQRLVKVDGRVRTDITYPAGFMDVISIEKSNEVFRLLYDVKGRFAVHRITAEEAKYKLCKVRQVSTGAKGVPLLVTHDARTIRYPDPLIGANDSVQVELETGRIIDFVKFETGNLVMITAGRNIGRVGVIVSRERHEGGFDIVHVKDSLGHSFATRIGNVFVIGKGNKSYVSLPRGKGVRLSIAEERDRRIAEKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK63</accession>
    <name>A0A0D2VK63_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364591.2">
        <property type="nucleotide sequence ID" value="XM_004364534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK63"/>
    <dbReference type="STRING" id="595528.A0A0D2VK63"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VK63"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="247"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="973" mass="105435" checksum="59FA703F79C03945" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMJ4</accession>
    <name>A0A0D2VMJ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMJ4"/>
    <dbReference type="FunCoup" id="A0A0D2VMJ4">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMJ4"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMJ4"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMJ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="155" mass="17233" checksum="57422B8AD3FB5B4C" modified="2015-04-29" version="1">MGATKAPLKKSKKAIDKLSARVVQVWSTQLARSLFYITMADLKAKGGFEEAKVHRIRITLTSVNVASLEKVCADLIKGAKDKKLKVKGPVRLPTKVLRITTRKTPCGEGSKTWDHYEMRIHKRLIDLHSPSEIVKQITSISIETGVEVEVTIADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPG1</accession>
    <name>A0A0D2VPG1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364188.1">
        <property type="nucleotide sequence ID" value="XM_004364131.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPG1"/>
    <dbReference type="InParanoid" id="A0A0D2VPG1"/>
    <dbReference type="OrthoDB" id="5962009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="85" mass="9157" checksum="77DA330D43E0EF2E" modified="2015-04-29" version="1">MVLKVNIEYCSACGYFPRMKEIERAIQKEFPTAKVTGEGGRSKSFEVTINGELVHSKLTSGKFVNPPVIVEAAKAIAAKQAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ70</accession>
    <name>A0A0D2VQ70_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363375.1">
        <property type="nucleotide sequence ID" value="XM_004363318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ70"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ70"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ70"/>
    <dbReference type="OMA" id="WRIQIFA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF30">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="430" mass="46605" checksum="EB590EDA6CEE5242" modified="2015-04-29" version="1">MVSINLRDPVRRMQMQVIVATWFAYAATYLLRKPVSVVKNAMAEELQMSTAVLGLLDTAFLMPYAALQLVIAPFADRVGARRILTAALIGAAVSMFALGWQSNQMVILLMLFGNGLSQSSSWPSCVKALAPWIPEENRGVVFGLWGTCQSIGGVLGTLIAVHQFQTGTWRDTFFLPSAIVFVIGVAQFFLTKTPQEAHMQPPNERAAAKALSDAHSVAVVDKITLWEAIKIPTFVNVCTAFFSVKLVRYCLLMWLPMYFLKHLNFDIATAGVMSTTFELGGAIGTPFIGLLSDRVFHGKKLATTFWSQTLSGVFLVFFIAVTPYSRFLGSICMGLVGVFSTGPDMMITGPIATELGEYQGRNVQASVAGFINGLGGIGAVIQGPLIGGIADFFGWSGVLMFIMVLSFFAAACLLPALRYERRRSMGLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQN7</accession>
    <name>A0A0D2VQN7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family B member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQN7"/>
    <dbReference type="FunCoup" id="A0A0D2VQN7">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQN7"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQN7"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQN7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="138"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="459"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="730" mass="77902" checksum="2DB6CA344211FD00" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQW5</accession>
    <name>A0A0D2VQW5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347806.2">
        <property type="nucleotide sequence ID" value="XM_004347756.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQW5"/>
    <dbReference type="eggNOG" id="KOG2259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQW5"/>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1413" mass="149182" checksum="25616465A7DE3C8A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRJ0</accession>
    <name>A0A0D2VRJ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004278</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348103.1">
        <property type="nucleotide sequence ID" value="XM_004348053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRJ0"/>
    <dbReference type="FunCoup" id="A0A0D2VRJ0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRJ0"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRJ0"/>
    <dbReference type="OMA" id="YADGWWE"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11619">
        <property type="entry name" value="HR1_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11911">
        <property type="entry name" value="SH3_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF12">
        <property type="entry name" value="CDC42-INTERACTING PROTEIN 4, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="16">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="502" mass="56175" checksum="CDEB958527D7AFD1" modified="2015-04-29" version="1">MTWGDELWDQNDAIANHTQEGVEFLNTYAKFLKERARIESEFGGSIRKLVKQFVSDTIPTKKKGEADEQSTGMRAWATLLSETEDIAKQHEVIGETLSNSLVEPAKNLAKDVSAERKKHLAESARLQANMKKQLDDLDKVKKNYEKCCKEAEAAKIAYEKAGKDMNMTKAQEDKFKVTWQQKQKLAEDAQAEYLIMVEKTNQVRKTYYYTDMPSVFTAMQRMEEDRTAKMATMFAQYADVERSTMSIVTTCLNNMTTEAGKVQPSRDTQLFIEDHKSGFQIPADVQYAEYGAKAVAPPPSAAIARVGTTKKKTGGLFGKKKKDDGSDDFSDLPPEKRKKRIGQKITELETEIGKEQKKKDSLDNMIKLYTEKPQLADEKAMAEARQQLAETAKTMDSLGKELYKFQCYLAAFENMAGGAPATPSRGGISRMESASSSQQDEDEDFPTQSCRALYDFAASGEGELSLTANETLTLLENDGSGWARVARGDDEGYVPESYIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRR7</accession>
    <name>A0A0D2VRR7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270406.1">
        <property type="nucleotide sequence ID" value="XM_011272104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRR7"/>
    <dbReference type="InParanoid" id="A0A0D2VRR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="280" mass="32286" checksum="2BE29C154ACA29F7" modified="2015-04-29" version="1">MADPARRARAAKPSMDTELLGRLVRQVEAHNKIVETQEMWRQHTKDDRDAQEDKADGARQSEHRPGSPSTSRRGDSDQHGHRDSSRGRDGGSTRSRNERDERRDERDSGSRRRDSGADDRRSSSSRESHSRHSAPRHRSDDDRERRSDQRWDDQRERDKADAQRIARARHRVATMDLDGWDHGGFTMYNKDSAQTAAISRGRRKKKRRSRSSSSSSSSSSSSTSSSSSSSESESDSESSHRRKHNRHSRRRRSRRRSESRSRSRSRSRSPRANSKRATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX79</accession>
    <name>A0A0D2VX79_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345326.1">
        <property type="nucleotide sequence ID" value="XM_004345276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX79"/>
    <dbReference type="eggNOG" id="ENOG502TG1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX79"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266152" evidence="1">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="255" mass="28378" checksum="90C22895643CCCC1" modified="2015-04-29" version="1">MPALNATHRCAVFALLALLLLLAVSSVSAAPINNNNNMADSSAIDAPPHPPAWPTYFYANYTVFYQPYGPYWQSAGGGEVFYDHSLPAMRSSYKQWCAPMFENPTAYNFTCEFLFVNDTAYYLNNGDPSHPPCCVFMTPFAPPKPDFFGDAKYAGETVMHAQNTTIWHKEGFGYLSYDVYGKPSDSYYPASLWGPLADGYLEIDYAWFDASVRPDPVHFAVPAQCQSSPACEDFASFSSVRLQLPLAGHVKYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXP4</accession>
    <name>A0A0D2VXP4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAMK/CAMKL/SNRK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344393.2">
        <property type="nucleotide sequence ID" value="XM_004344343.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXP4"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="416"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1295"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1422"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1546"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1446"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1469"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1574"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1785" mass="181610" checksum="D67784952D873593" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0K5</accession>
    <name>A0A0D2W0K5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase FGGY N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342933.2">
        <property type="nucleotide sequence ID" value="XM_004342884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0K5"/>
    <dbReference type="STRING" id="595528.A0A0D2W0K5"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0K5"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0K5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="508" mass="53839" checksum="49EB6161E64A3A27" modified="2015-04-29" version="1">MVVVGLDVGTTSIKIVVLDPAQTLYAPVWAAEEQHEAYTIHSSERAEQDPSVLLGVAVNLLRSVPETLAARVDRIALTGQMHGVVLWSQQNANAAANQTPNLKDSSLLPVSPLITWEDGRCSSAFLADLHKQATSQMQLSSGYGVASLAWLAKNNPDILSKATACGTIMDFVACSICEDAQPCMTPTNAASFGAFDAAQSCWQQPYIEEVAGIRFDLLPRIVSSGTRVGRLKSGILQADRTTEVQVLAAEGDHPCSVYAALNIIARPSSSVPAVQPSHSVPQAILNMGTSSQVAIVVPRSGLPADLKLNPSVEIRPYFAPELCMIVLASQTGGNALAALVTAFSRCTTELSDDAGAISSDAAFSKLIEKGCSLVKQTDRPPSISFRPTFYGERADTAMRGQIANIGLDASGELDFSFVGLFVAACRDLMLHLATMLDQLVGDTIAESSPTLLHRLGIQNLIATGRAIQRNPLLQHFASAAFRVPVRVLPLDSRADSALGVALLALPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGM3</accession>
    <name>A0A0D2WGM3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365084.1">
        <property type="nucleotide sequence ID" value="XM_004365027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGM3"/>
    <dbReference type="STRING" id="595528.A0A0D2WGM3"/>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGM3"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254359" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="32"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="692"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE88575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110914" checksum="18C7A49CADDA57F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHR6</accession>
    <name>A0A0D2WHR6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHR6"/>
    <dbReference type="STRING" id="595528.A0A0D2WHR6"/>
    <dbReference type="eggNOG" id="KOG1410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHR6"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHR6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34786" checksum="27A41581B1EAA642" modified="2015-04-29" version="1">MYCKRTRYKSCIHCFALIRNALAANFVNLGVMTLYHDDSVETALVSFLQLMSSIPTTDLVSIPKLTKNFFSALDYFLQDLTSYLFVMPVTLYISVLGCVEEGLKHIDRDVRDLCCRIVENITGYVHRHMSREKPSTDRSQIEQLLAQAPQALPHVLELILNMIFYDTDRGCHMLWRPLLGLILLFEKEYVQIRDLLIESSPPARVHIARAAFEKLMADIEPDLTLRTKDRFNANLQHMRAALRQGVSVRDATAFGTTIVSSPLEGLGMFDGGTMQAQQHVHLLHNAEYGTNAQASPRFYQGAGATTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHT2</accession>
    <name>A0A0D2WHT2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CPSF3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHT2"/>
    <dbReference type="FunCoup" id="A0A0D2WHT2">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHT2"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHT2"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="54"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="8">
        <location>
            <begin position="278"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="9">
        <location>
            <begin position="506"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="788" mass="87198" checksum="ADF6919DFAE8689A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI51</accession>
    <name>A0A0D2WI51_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI51"/>
    <dbReference type="InParanoid" id="A0A0D2WI51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="272" mass="28454" checksum="165CCD6A832C139D" modified="2015-04-29" version="1">MLSSLSSGCVVANSERNAGVRGSVRRHGAASSAFCDDPPSRREEPLAYRPRGGSPPRAVKLVSLGKPKSDRSPTGEIRQQPATSTAVRVGQAATKLASAESTSHALLASEICSRRVHRCMAARDCHRCSDKRSAQLDRSTLRQSSGSELTAFHRRLTRLVRHNSGTAPNRDTALCRIKNRTSCGRLGTGVAVVVAATAVVVAALAVEAEDRGSLGGRWDDAFLPFLPAVVARAAAAASSPSLGACSRDAGHVVSRSSSRLDSSTAATLGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIN5</accession>
    <name>A0A0D2WIN5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366032.2">
        <property type="nucleotide sequence ID" value="XM_004365975.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIN5"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIN5"/>
    <dbReference type="OrthoDB" id="548295at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIN5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="242"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="890" mass="97392" checksum="37F27E0B4246917F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJD2</accession>
    <name>A0A0D2WJD2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364324.1">
        <property type="nucleotide sequence ID" value="XM_004364267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJD2"/>
    <dbReference type="InParanoid" id="A0A0D2WJD2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="100" mass="10501" checksum="B9F00934971AA301" modified="2015-04-29" version="1">MALLFIPASMCPGHQWLTGGGALLRDAAHRAEMALGVLPSPFLADLARLRTTNDAVQRSSVVPLCSLDAAAILPFVEMLRSPMVCGLPFRPLIGGDGGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJG0</accession>
    <name>A0A0D2WJG0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGC/YANK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364379.2">
        <property type="nucleotide sequence ID" value="XM_004364322.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJG0"/>
    <dbReference type="STRING" id="595528.A0A0D2WJG0"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJG0"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJG0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="452" mass="51582" checksum="5B5BA4B789018E08" modified="2015-04-29" version="1">MGCIASKPPIDFSADVNFEHFKLLRSVGRGAFGKVCIVLKRDTKKLYAMKYMNKEKCLQKRAIRNVFNERKILESLQHQFIVNLWFAFQDEEDLFFVVDLMLGGDLRYHAQRSGAFSEDRIRLYTAELMMALVYIHDRNIIHRDIKPDNILMDENGHVHLADFNVAASIRKGSLLYARAGTKPYMAPEILNKSGYNQSADWWSLGVCMYELLRGKHPFRGGTTEEMLEMIQSAPIKYPTTWSEPCISFLSGLLERDVTKRMTITSENVQEVLKHPFLASLDYDKLINKELVPSFVPDKDKVNCDAMYELEEMMLEDNPLHKKKQRLQKTTMSKQEQAKRETIGAELQRIAEKFTVYDRSKVKSTPDVALDTNIDDDEITSASPRPQRASGLAVFSNEHDSSHMSEDENALRGDSDSRRVRSQSTDPDPLELPTRLVTPVVDDGSSTSSPIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJI0</accession>
    <name>A0A0D2WJI0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364419.1">
        <property type="nucleotide sequence ID" value="XM_004364362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJI0"/>
    <dbReference type="InParanoid" id="A0A0D2WJI0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="112" mass="11700" checksum="C7C909013AFD416F" modified="2015-04-29" version="1">MLWVLDDELWKAVGLFFWVNGGFVVVFFIVVVFINILTRRLQRAKELNAAAATRASSSGASGSSSPSAAAAAAASVPHAAAVPATEQQSAVVDNDDSAASPATKPKRRSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJP6</accession>
    <name>A0A0D2WJP6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_001669</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJP6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJP6"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJP6"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJP6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF9">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="557" mass="60231" checksum="210C63C9EADDA788" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK16</accession>
    <name>A0A0D2WK16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349807.2">
        <property type="nucleotide sequence ID" value="XM_004349757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK16"/>
    <dbReference type="STRING" id="595528.A0A0D2WK16"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK16"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF136">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254429" description="SET domain-containing protein" evidence="4">
        <location>
            <begin position="35"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="512" mass="58228" checksum="A4DA4C3F4263D708" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKK0</accession>
    <name>A0A0D2WKK0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKK0"/>
    <dbReference type="InParanoid" id="A0A0D2WKK0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="35510" checksum="A5361C8A21782909" modified="2015-04-29" version="1">MLNDDYSDNRNDENDNNDDNDEYHLTWNDSLVSPQVLRALDQIEIAFARQHSPACQDTFVQVSASTDHAQHTLPAITLVSGGAEGADLAMATAAVHAGWCLNVVSFATHRPKLPPSCPPTTVTQLSTNELAACTAGLHRANRTLCRSIERVSPFVFNLLRRNVHVARRATVMLAVAGFEGATRRSITQPAITELLRGAGPSTSSSPLATSACTHRRVAGGTGWTCQVFVDAATDAARTRLHMHERLESGLYVFDQGSNRWHRHALQRVGTGDNDVQSHWDVLPALPPKPLTSQSLFVAGVGTRELNSAGRAAIHDVIEAWSQPRCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKV2</accession>
    <name>A0A0D2WKV2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364527.1">
        <property type="nucleotide sequence ID" value="XM_004364470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKV2"/>
    <dbReference type="InParanoid" id="A0A0D2WKV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="104" mass="11185" checksum="43D925F534F1D946" modified="2015-04-29" version="1">MASSNLAPEMADLEARRRLHASTLLGDLTTLVHLAAGARGLLLGTRLGPSSTRPRGPALPSTATASAAECQSPPHHHRSHPTDVRWPSLIAHYVRRLRFPRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW6</accession>
    <name>A0A0D2WKW6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348982.1">
        <property type="nucleotide sequence ID" value="XM_004348932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKW6"/>
    <dbReference type="STRING" id="595528.A0A0D2WKW6"/>
    <dbReference type="InParanoid" id="A0A0D2WKW6"/>
    <dbReference type="OMA" id="EDQHENP"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="990" mass="108907" checksum="B546047A1805A839" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL96</accession>
    <name>A0A0D2WL96_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349206.1">
        <property type="nucleotide sequence ID" value="XM_004349156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL96"/>
    <dbReference type="InParanoid" id="A0A0D2WL96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="380" mass="38798" checksum="F8AB1AB965E69A53" modified="2015-04-29" version="1">MAAVDVVGRLVATALQPLLLSATQPSSSSASASVTAQEKLWDVLSSTARPAAVRCPAQQQPATTTTTTTTAHSANISSATSNNSSGNSSSSSANALRMMMMMNGPLLPTKAGDDLLSDEPVQDVVAAAAAAAGAAPTTTQTAAALDDTNSSKKRLWDVVTSGEIKRAKQWRGAPGERALFLALKMDPNTVPLPVVQKIDMGTHQKHHSKTGSTATAAAAASATFDLQDDFGFFGGSAAADAPQSNARPSVPSGGLLDFSLFDEPAAPSVSATAGRSLHRPPSSAPQPSSLALLDDEFLGFSSASVPPAHPSAGTLVDPAKASVLASLPASFLGATIPSSAAAPPLSDQAKRLLSGLPDYSYMHSHVLMFPTRDVQNSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLG1</accession>
    <name>A0A0D2WLG1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349296.1">
        <property type="nucleotide sequence ID" value="XM_004349246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLG1"/>
    <dbReference type="InParanoid" id="A0A0D2WLG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="557" mass="59115" checksum="A20ECC3CBB552C37" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLP9</accession>
    <name>A0A0D2WLP9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLP9"/>
    <dbReference type="FunCoup" id="A0A0D2WLP9">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLP9"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLP9"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLP9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="293" mass="31637" checksum="23BA9CE57580B57F" modified="2015-04-29" version="1">MAEPLRYSGAAYFRQRIVLSVLSGRPVRIDNIRSTEDSPGLSEYEANFLKLIDKLTNGSQTDINYTGTAVLFKPGFFAGGQVEHDCGTERAVGYYLEPVISMAPFGKAPLSLTLTGITNSAQDPSVDVLRTVTLPTLKLFGLEDGAELRIARRGAPPLGGGQVFFSCPVVKQLKPVQLLEAGKIKRIRGIAYSTRVSPQTANRIVDAARSLLNTFIPDVYIYTDHYKGAESGRSPGFALSLVAESTTGVLTSAECAAEAGMLPEDLGLRTAKLLFEEISRLTSHRYTNVASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLU3</accession>
    <name>A0A0D2WLU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348944.1">
        <property type="nucleotide sequence ID" value="XM_004348894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLU3"/>
    <dbReference type="InParanoid" id="A0A0D2WLU3"/>
    <dbReference type="OrthoDB" id="687020at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266452" description="Phytocyanin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="19467" checksum="EC70C49A400D2B31" modified="2015-04-29" version="1">MHRLISVIALVCALFAGVSFGASTTPVTWGPSPINTVALSTGDSLQFTVGAGHTLVRQQSCSSAPCCTFGAGDTMIAGSGGAATQTFSAAGTYYYACNIGAHCSSLSMHLQVVVTDAVSTTPAVSTTAATTGGSVSVEVSTTSAVSVDVSTTPVSLSTTATSTAVSPTHSRTNNGNRICISPLLLGVGILAGVARCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMF2</accession>
    <name>A0A0D2WMF2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMF2"/>
    <dbReference type="STRING" id="595528.A0A0D2WMF2"/>
    <dbReference type="eggNOG" id="ENOG502S5A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMF2"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMF2"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="62469" checksum="95EC640B83603213" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMM8</accession>
    <name>A0A0D2WMM8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMM8"/>
    <dbReference type="InParanoid" id="A0A0D2WMM8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="176" mass="16739" checksum="C2535D62EEC372E6" modified="2015-04-29" version="1">MSSSQPVSAASAGGSGTDSVGLVASIASLASTGAGPVNVDETNHGAAVKVVLPGALPATNHGFSTLVTPKVATSLAGAVETACTANGSTTGTSGAVKGAGGATQDVLSISEGCGAKDGETGFAARRLVNRSFSSSRSSGKLSVGRPGSVCPASSGAEAGLYDEIGWWVSVAAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMV2</accession>
    <name>A0A0D2WMV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14 beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMV2"/>
    <dbReference type="InParanoid" id="A0A0D2WMV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="2">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="666" mass="70825" checksum="7B97E346ED7E8A94" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNJ1</accession>
    <name>A0A0D2WNJ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363338.1">
        <property type="nucleotide sequence ID" value="XM_004363281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNJ1"/>
    <dbReference type="FunCoup" id="A0A0D2WNJ1">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNJ1"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNJ1"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNJ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="86" mass="10259" checksum="EE8836796D524E83" modified="2015-04-29" version="1">MEQQISSIPGYDTDKELQQFVEIEQQKARFHAQVHKFTEMCWDKCIDKPGNRLEAKEEACLTQCVERFLDSTHFIVNRLDEIRKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNV8</accession>
    <name>A0A0D2WNV8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364016.1">
        <property type="nucleotide sequence ID" value="XM_004363959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNV8"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNV8"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22673">
        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1143" mass="118293" checksum="153CD868B85A9A02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNX9</accession>
    <name>A0A0D2WNX9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase zeta catalytic subunit</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_003843</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363571.1">
        <property type="nucleotide sequence ID" value="XM_004363514.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WNX9">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNX9"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNX9"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNX9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000005">
        <property type="entry name" value="Putative DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="20">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="1396"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="1736"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="2040"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="18">
        <location>
            <begin position="2480"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="688"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="807"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1548"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1899"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1986"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2414"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2635"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1577"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1941"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1994"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2019"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2416"/>
            <end position="2434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE92975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2719" mass="296505" checksum="4F4F18D2CBB71B66" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPM9</accession>
    <name>A0A0D2WPM9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348034.1">
        <property type="nucleotide sequence ID" value="XM_004347984.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPM9"/>
    <dbReference type="InParanoid" id="A0A0D2WPM9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPM9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118823" checksum="86B2D34346696E9C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ32</accession>
    <name>A0A0D2WQ32_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metalloproteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363579.1">
        <property type="nucleotide sequence ID" value="XM_004363522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ32"/>
    <dbReference type="STRING" id="595528.A0A0D2WQ32"/>
    <dbReference type="MEROPS" id="M80.A02"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ32"/>
    <dbReference type="OMA" id="DFDEHAI"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10463">
        <property type="entry name" value="PUB_WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47796:SF1">
        <property type="entry name" value="OS08G0500800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47796">
        <property type="entry name" value="ZINC METALLOPROTEINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="220"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="650" mass="70389" checksum="6DFFFAD4E24246F2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ55</accession>
    <name>A0A0D2WQ55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363600.1">
        <property type="nucleotide sequence ID" value="XM_004363543.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ55"/>
    <dbReference type="FunCoup" id="A0A0D2WQ55">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQ55"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ55"/>
    <dbReference type="OMA" id="MRVAMYY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="36763" checksum="01B80005ADB520D3" modified="2015-04-29" version="1">MADNVAAVLHGINDIRMEPVARPTPGPNDVLIAMKAVGICGSDVHYWTHGRIGDFVLTCPMVLGHESSGTVVEVGANVKTLVAGDRVAIEPGVPCRLCSYCKTGRYNLCPDMQFCATPPVNGSLARFYVHPADFCFKLPDHVSFEEGALLEPLSVGVHACRRANVTLGSRVLVCGAGPIGLVCMLAAKAAGASEVVVTDIDQHRLDVAKSMGAHKIFRVTSRDAKEVAAQIAELAGGRLDVAIECSGAEASLRTAIFSTRNGGVVVLVGLGAPEVNMPIVDAAVREVDIRGIFRYVNAYPTALAMIASGTVNVKPLITHHFKLNDAIQAFETAKTGAGGAIKVMIHCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQY3</accession>
    <name>A0A0D2WQY3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347626.1">
        <property type="nucleotide sequence ID" value="XM_004347576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQY3"/>
    <dbReference type="InParanoid" id="A0A0D2WQY3"/>
    <dbReference type="OrthoDB" id="104224at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQY3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="60580" checksum="91C1ED9BF0CE76C8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRA9</accession>
    <name>A0A0D2WRA9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRA9"/>
    <dbReference type="STRING" id="595528.A0A0D2WRA9"/>
    <dbReference type="eggNOG" id="KOG3631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRA9"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRA9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21222">
        <property type="entry name" value="CH_PARV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="98"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="287"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="398" mass="45540" checksum="A367A2FC5A18A5D3" modified="2015-04-29" version="1">MDDFSLNPLFLSAPLLLRVITRLCLSFFALCWRHSHEYLQVQLPATRCCSDLRPARIPYSLTTLHASIHTELLVQSQFRSSLKQTSVLPNTQCEASGRIYRQLVLAQLFQQRPQGQTPDQVIVRDLAQDLYDGIILINFLQTVTGKEIKYNLLAQSDKSKRENLTFLFKFLKQEFNMEPSEERWTFEGIFRKDIAAILMLCVELGYRLECPNEIPSNVRVAVVNRVSNNGVITNKTVAYDITDNRQHLGALGAEGAAKVLADEKDVAISTRDVIDDLFEANDPERLQLIQEKLVQFVNNHLRKISVQVTDLALQFHDGVYLILLLGSLGDFYVPMNMYHLTPINDDMKVHNAEVCLQLLEKMGLSRNGIYAREIVTRNLKTIVRFLYLLYTAYRPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSR7</accession>
    <name>A0A0D2WSR7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346453.1">
        <property type="nucleotide sequence ID" value="XM_004346403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSR7"/>
    <dbReference type="STRING" id="595528.A0A0D2WSR7"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSR7"/>
    <dbReference type="OMA" id="HADGYQK"/>
    <dbReference type="OrthoDB" id="543442at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="157"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="427" mass="46793" checksum="02E21FF406466C94" modified="2015-04-29" version="1">MAARAAAHAQPQLAAEHQLLRSELVIKDQELATNKQELATRDQALAAKDQELQQLRFDLAAKDQKLATTEQELIAKNQQLAVKAQELTAKDQALATNKQELATKDQELQQLCSNLQSALDRIGVLERNQGAGGSASNFDGPIPQVPLATLASATNNFAADSLLGEGAFGRVYSASLPAPPVAVAIKKLSAESIQHYAAFQAELKSLSKFRHPNIIVMLSYAEAQGDYCLVYEFMPNGSVRDRLSCKNDTPPLTWSQRHRIAADVARGMHYVQTALPDQVLFHLDLKTDNVLLDAYFNAKVSDFGLVRAAQHLDDKSYLRTQNVQGTKAYMCPVFFGESKITIKTDVYAFGMILLELVTAAKPGPTLKTDMRKAVKTQKFVEMLDSALHPTEAEGQSVSEIVTLALECLDDDADERPSFGQLIVQLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTA4</accession>
    <name>A0A0D2WTA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_006041</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345631.2">
        <property type="nucleotide sequence ID" value="XM_004345581.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTA4"/>
    <dbReference type="FunCoup" id="A0A0D2WTA4">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTA4"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTA4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="453"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="165"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE95605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="722" mass="78983" checksum="1048253D64E74909" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTA7</accession>
    <name>A0A0D2WTA7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTA7"/>
    <dbReference type="STRING" id="595528.A0A0D2WTA7"/>
    <dbReference type="InParanoid" id="A0A0D2WTA7"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="333" mass="35227" checksum="C822F7778AEE73BC" modified="2015-04-29" version="1">MGRIWREILKLEIVAGTVTPPPSRLARIGCKMEKCRWKERIAKSLCCCRCCCVAQAYEALEVGEVPVGCVIVLRETGQVIGRGCNRTNETKNATRHAEFEAIDEVLRWVEANSDIAAALGQPATTESPARGPTTASQPVAIPTARASSSAAASASSASTSSPSSPSTTLPHSSCSPTSPPHVGPFSMRRAGSLSASPHSPPTLSLFLSERATSVATSTQIFQHCDLYVTVEPCVMCAAALRLVGIGAVYYGCGNDRFGGCGSVLDIHSEMHRRASSDDASAGAADPNRNSRPFRCISGIMRLQAIQLLRDFYQSENPNGASVCRVLIASGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTZ1</accession>
    <name>A0A0D2WTZ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346382.1">
        <property type="nucleotide sequence ID" value="XM_004346332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTZ1"/>
    <dbReference type="STRING" id="595528.A0A0D2WTZ1"/>
    <dbReference type="eggNOG" id="ENOG502SAGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTZ1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1199" mass="131093" checksum="CA785B7D7E390125" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUF0</accession>
    <name>A0A0D2WUF0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345583.1">
        <property type="nucleotide sequence ID" value="XM_004345533.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUF0"/>
    <dbReference type="STRING" id="595528.A0A0D2WUF0"/>
    <dbReference type="InParanoid" id="A0A0D2WUF0"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUF0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="717" mass="77312" checksum="105A555A688B3C16" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUX3</accession>
    <name>A0A0D2WUX3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345010.2">
        <property type="nucleotide sequence ID" value="XM_004344960.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUX3"/>
    <dbReference type="STRING" id="595528.A0A0D2WUX3"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUX3"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUX3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="608"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="729" mass="78995" checksum="86DEF58D3361E6BC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUX8</accession>
    <name>A0A0D2WUX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUX8"/>
    <dbReference type="InParanoid" id="A0A0D2WUX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254681" evidence="2">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="269" mass="29616" checksum="75872A46DA85EFA3" modified="2015-04-29" version="1">MAKDCVQSFFLLLFSELFLAFERMAPNGDSAATPSSPPPAPHQAPAAQQPTATLWEQLVLSRFAKADVRQPFEWSSVRTGAIVGATSGAIVALGLTATRRTDRPLSTTLPKLAATWAMLGATFAGFRELVSTNPSNGPVTSTFIASTAIGIFHAGLRWTPLPPAQALSRVALAATIPAAIHWTALASQKWQHEYTLKQIYEQELERQREAAGLPKPVPWYDKLQVRTLSPDEKMERLLAKVKAYEARLKAEEERKEAAERQAQQKKQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV89</accession>
    <name>A0A0D2WV89_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_006991</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343715.2">
        <property type="nucleotide sequence ID" value="XM_004343665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV89"/>
    <dbReference type="STRING" id="595528.A0A0D2WV89"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV89"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV89"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266604" evidence="15">
        <location>
            <begin position="24"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="17">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="17">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="17">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="711"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1000" mass="105824" checksum="DBF7F2F034E776C2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVE6</accession>
    <name>A0A0D2WVE6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRCA1/BRCA2-containing complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345240.2">
        <property type="nucleotide sequence ID" value="XM_004345190.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVE6"/>
    <dbReference type="STRING" id="595528.A0A0D2WVE6"/>
    <dbReference type="MEROPS" id="M67.A03"/>
    <dbReference type="InParanoid" id="A0A0D2WVE6"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="280" mass="30989" checksum="FC08739C5668ACB2" modified="2015-04-29" version="1">MIPTLARCVLSADAFRTCFTHALASEHEEIMGLLIGELTVSEAGEDESHIHSVCLFKRSDRQKDRVEISPEELAAATTEAERLSGIADRDLRVLGWYHSHPHITVWPSHVDVNTQAAYQQMDKNFVGLIFSCFHTEPNKANRLQVICFQAVPEPSYLSSTGSGKFVSREVPLQVVSPNGLTASFSDSLSLLASVMVEEERDLYSPANQSPETVEEIMNAIHNGSVFTKSMTGIAENLCIPLIRVLEAQLGRNHQRMLELNRLLDSPESGGQLLDMSDVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVV9</accession>
    <name>A0A0D2WVV9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344413.2">
        <property type="nucleotide sequence ID" value="XM_004344363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVV9"/>
    <dbReference type="STRING" id="595528.A0A0D2WVV9"/>
    <dbReference type="InParanoid" id="A0A0D2WVV9"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVV9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17429" checksum="EB7E74EF0B181820" modified="2015-04-29" version="1">MTVIPVRLSPEARLNAPQNINFDTDWVIVELQGVVSSKAPELDGLTAGMLAFDDKGNPNLTIGQQMLVGKVTPLKTPIAVMRRKTSTTDAAHSQTSDTPQNNDNNAMQIEPPSHPQPSPQHPAASTSTEYEIAAIVHHKLLFKTRPKNLLSESSREKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVY0</accession>
    <name>A0A0D2WVY0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344447.1">
        <property type="nucleotide sequence ID" value="XM_004344397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVY0"/>
    <dbReference type="FunCoup" id="A0A0D2WVY0">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVY0"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVY0"/>
    <dbReference type="OMA" id="LFWEVPK"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVY0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="48316" checksum="A27B579855046DD9" modified="2015-04-29" version="1">MSGLRHALVRFLAPLASILLWYVFSVGLTYYNRWLLRSYGFHFPITLTMVHMTVNWTLCWIVRAADESRQNRPRTTLNWRQTLTKVVPCALMAALDIALSNSAIMMVTVILYTMIKASSIVFLLGFAILFRIERFRANLIAVVLSICVGLILFSYGSTTVDVLGLFVTLGAAMSGGLRWVLVQVLVQGNAGHGHGPSKPGPEQRERILNGPLDTLYHLTSVMALLLLPLAMYFEGAALFSSDLFHDSATRLATTIAVLLVGGTLAFMMNFCEYLLIWQTSGLVMAVAGVVKDVVTIAISAMFLHEDRFSEINIVGGVALFFGVAFFHYIKYQQHKHVGGGMEADAGSATHHFDSSADERYAYSRTSDTSRLLSQGNDIQLDQFQQVDAYPNVRNGSRVSPESHSPLSDDESTIRVYPSRFRQRKETSSKRADHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW10</accession>
    <name>A0A0D2WW10_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343430.1">
        <property type="nucleotide sequence ID" value="XM_004343380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW10"/>
    <dbReference type="FunCoup" id="A0A0D2WW10">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW10"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW10"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="494124at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="15696" checksum="713B9772CDB0F700" modified="2015-04-29" version="1">MGKPRGLRTGRKLLNDRRESLWADKFLKKKMLGTIFKHSPFGGSSHAKGIVLEKVGVESKQPNSAIRKCVRVQLIKNAKKVTAFVPNDGCLNFIEENDEVLVAGFGRSGHAVGDIPGVRFKIVKVANVALLSLFSGKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWV5</accession>
    <name>A0A0D2WWV5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343433.1">
        <property type="nucleotide sequence ID" value="XM_004343383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWV5"/>
    <dbReference type="STRING" id="595528.A0A0D2WWV5"/>
    <dbReference type="eggNOG" id="ENOG502QQ4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWV5"/>
    <dbReference type="OrthoDB" id="7446186at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWV5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="766" mass="83138" checksum="B6650ED41CE60F2E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWY8</accession>
    <name>A0A0D2WWY8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343497.2">
        <property type="nucleotide sequence ID" value="XM_004343447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWY8"/>
    <dbReference type="STRING" id="595528.A0A0D2WWY8"/>
    <dbReference type="InParanoid" id="A0A0D2WWY8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="480" mass="50385" checksum="C90195BC633E3859" modified="2015-04-29" version="1">MGRHAKHSHTKRQHQQQQYYSASRQPPITPNMPRKHLNFTPASAFAPLGSSPLFTPASSVASERIAPVSASLSSRVEKAKSGSTSTKLNNRKKRAAAAAAAAATAAAMAAEFGTIDGEFSGGEGGVSAGADMASSHHAVSETVSTVAAAADRFAFHASGGGASLLPPITPGTANSVDSINGDGEFFADLDLGVAASVRLQRSRSREFESDSRNRSPTKSPLPIRVSRASASSSWSITGVVSKGLRAVGDFLLARTDAPSGGSPKRHFTVSELTERILQLESEMSILRKRVADQPLQDHAPSMSNDAFVPPPPPMPPMCMGAPPPPPPPLPPLMMPKEYKIVLGRASQKTQRDENDGEASGKKKAKGFSVSLEDIQRVALRRVSSNQSVTTPGSAPASAKDITSALAMEAKAFQLKRNDSIRSPGGTPMRPRKATNASLLENAGSDASHGVRTLLRRARTESISSPVRHSPFGSPSAAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXI1</accession>
    <name>A0A0D2WXI1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXI1"/>
    <dbReference type="FunCoup" id="A0A0D2WXI1">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXI1"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXI1"/>
    <dbReference type="OrthoDB" id="10259763at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="57214" checksum="0CFD3102C6A2F71E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXS3</accession>
    <name>A0A0D2WXS3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342708.1">
        <property type="nucleotide sequence ID" value="XM_004342659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXS3"/>
    <dbReference type="eggNOG" id="KOG3944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXS3"/>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE98080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="338" mass="36231" checksum="9F5C5365F034DDB8" modified="2015-04-29" version="1">MELVKEALQPWLESIDLDMFEPANLLSLATTLPIFPMFFVAHCLSTAAAIRKSDPNARRFAVTSPIASILGYWLCCIGSGLAVDVVLGQPFKFLQNDYEFKAVLICWLCVFLSPFDLGYKLCHFAPVKILLTIGKEIRRARKVQDGVLAAGSTKYFVAPIVCGTLNGAGSSIFSVIDQALRGAPISVDLRAPELGTKAAFYSAVALTLGAHDIIPVRNFLPKWQPVETLAELVVVVVVAVGVLKVLASIAPLSALKLNERCARLSPDTLLFGLFCWFVTIADPAPADATAASSNPDTKTTTAAPAKANNPATPSKSAQTSTQTNPRSTEKQGKHSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0S4</accession>
    <name>A0A0D2X0S4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M16C associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365880.1">
        <property type="nucleotide sequence ID" value="XM_004365823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0S4"/>
    <dbReference type="FunCoup" id="A0A0D2X0S4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0S4"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0S4"/>
    <dbReference type="OMA" id="CVEGPFW"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0S4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="2">
        <location>
            <begin position="453"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118392" checksum="A585B99A8696F743" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0T0</accession>
    <name>A0A0D2X0T0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0T0"/>
    <dbReference type="InParanoid" id="A0A0D2X0T0"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0T0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="234" mass="25959" checksum="017F74255DD1B0EA" modified="2015-04-29" version="1">MYVTTIATAFGDMGQVSAYDLVRALTAIASTPATQLPKITAYLRNFLRAYRDQIFEIWQDTALKAEIDADPVAQDAWSFFECAVSYKQIRDAFDSLAKLGPSSEEDEWESLVRASLRSRDEAASSRSMIPPPTSQIKLSGRLRSAILRKAEEVILRIVLQLDNFPEWAQEANRVQTAVNLRRGFDLALHHITYIMETGLDANPILSGVTSLTGAILSLPKIAPATQTLPLDEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Z2</accession>
    <name>A0A0D2X0Z2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_001309</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349829.2">
        <property type="nucleotide sequence ID" value="XM_004349779.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X0Z2">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0Z2"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0Z2"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0Z2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="247"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1564"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1584"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1610"/>
            <end position="1777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1777" mass="196968" checksum="7D6F8CC9D7414EB0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1L1</accession>
    <name>A0A0D2X1L1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1L1"/>
    <dbReference type="STRING" id="595528.A0A0D2X1L1"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1L1"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="252"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="348" mass="37465" checksum="163AB95720B599CE" modified="2015-04-29" version="1">MLHHLCRSTIRLHVAGRAAYTSLACTAGRLPHDPSSRHPTITIPTFATPAAAAALLVPLSAAKRVSVAAVRMQPPARGMAGHSKWKTIKHAKAATDAKRGKLITKFSREISSCVRESGEDPVFNPRLGAIIDRARQNDVPIDKIRNAIKVAASGKEVDDKAQVHFFEARGPGNVSLLIETLTENTRRTFPEIRALLSKVGGEPAPVGYIFKRVAVVTIRLASDEDLAKLVGSVTGGAPSAPLRSLTQSQWDDLALEVGVHVGAEDTEADVEESTLSFICQPSDSAAVRDAATKLGVGPPMLRIDFLSESQVSIGNAETQEQFEWLMEALDDHADVMNVFDNLDRSQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q7</accession>
    <name>A0A0D2X1Q7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q7"/>
    <dbReference type="InParanoid" id="A0A0D2X1Q7"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Q7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="286" mass="31943" checksum="7C47FE5FF21BD8DA" modified="2015-04-29" version="1">MELVAETNDWPFGYNCTKSLSDVPQAGDVALGAIIVAGLFISYLFQIIEIIYRRSSKGISCFFLLLGTLNAFCLFDNSIVYQFDVIACCPEWDGSDCQKQLLKLYQLGLQFSSLVFIYGLFLVFFPKRDESNAAEWRRSCISAGVCFAAVSIFASIHAIIATQEGVQSSMLSHYADVLGYFGVGFVLCQFVPQIYKTIKEKSAGSFSIPMLIIQTPGSFIFMYFLATGHNPEVTSWLPILITGILQTILLSSCIFFAIRDRRARKAQDLERKPLLEEVEVKATPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1X6</accession>
    <name>A0A0D2X1X6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349449.2">
        <property type="nucleotide sequence ID" value="XM_004349399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1X6"/>
    <dbReference type="SMR" id="A0A0D2X1X6"/>
    <dbReference type="FunCoup" id="A0A0D2X1X6">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1X6"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1X6"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1X6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="362"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="62555" checksum="487BF757BE149FD2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X209</accession>
    <name>A0A0D2X209_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X209"/>
    <dbReference type="InParanoid" id="A0A0D2X209"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="259" mass="29316" checksum="99FFD732308D1350" modified="2015-04-29" version="1">MWLRDHFNRATHDDRRWLEAHKKADTAQQTDGGGRCRGICHAPDIGCWEHRDGSMKETLQLLHHWWKQDDVVPSSAKLLRSCVTFFLNEALRPVAYLLHTYDKKMTLTWQHAVGSLAGTVLSMAIGAFWHSPYGFLDEWMRLNGIRISKNRTPEQAKQQNKEMKMGLAISAFSLYVQFLTIAVLLTQLNLGFTTDVATACKTFATLAGIWFAFTACSAGADFAWNQRAVGLLHIFLGHTFVTMIAGTLLSQFVTKWLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2N8</accession>
    <name>A0A0D2X2N8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363500.1">
        <property type="nucleotide sequence ID" value="XM_004363443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2N8"/>
    <dbReference type="FunCoup" id="A0A0D2X2N8">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2N8"/>
    <dbReference type="eggNOG" id="KOG2046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2N8"/>
    <dbReference type="OMA" id="KWLMDGI"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2N8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="18822" checksum="6855BDEDACC98506" modified="2015-04-29" version="1">MSNRPAAMGLDAELAAKRAAKYDPVAEGEAIAFIKEQTGIVVPAGSDNVHSALKDGSVLAELANSVKPGSFSNTKAQTMPFKQMEVINKFLEVASSLGVPITNSFQTVDLFENQNIGQVIICINALKLAAQGKGKLNSHASKEVVTDHSVIPMQTHGYTGGANASGQNFGLGRQIVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X341</accession>
    <name>A0A0D2X341_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X341"/>
    <dbReference type="InParanoid" id="A0A0D2X341"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="358" mass="39200" checksum="126381DE08C2B3FE" modified="2015-04-29" version="1">MTNPRFLLLSTLTAYSPSPSCHGNNFLPLGGRAEPIILIILDLANGSIGGIFKIRTPLAFFQHPPRQEARAVLVLAPIRASPVLCKQWAELRVPGGEKQRSGSNCRSSESKPQFRSGVFQSRTTSGSSTAAHATAVCTVPSMQGCCWMSTVRSYRAEMANIRAGNSFRFSRRRVKRWTDGRRWGRGYRLASGSFVYKEIDEHGSILRNGLTKVVGEDDDDTSVGTVTYSNTDNNAAELNNFVAPPDLFAPLLNAHARANDEMLLPLIHRLIDLLNVNVADNINPAPPPIAEAPAIVRADVPFDLDSLLLPPFLNDLVDDEPKFADLFIDNVNFDAPVQPADSPMAAGLRFMLDSPVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3D6</accession>
    <name>A0A0D2X3D6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3D6"/>
    <dbReference type="STRING" id="595528.A0A0D2X3D6"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3D6"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3D6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26819" checksum="5D9B1840F3C387A6" modified="2015-04-29" version="1">MQPTIGGGARCAKYLLVIFNLLFLVLGGTILGLGIYTTQRGSIEQLKSFNLSWGLIIVGAFIFLLAFFGCCGANRESRGMLKAYFAFMIIFIAAQITIAVVAWKYSGDLDESLFDSFNSADTDTKNDIQNDLKCCGFWNSTDSTTTDPKNVCHIPQPGYANGCYEDIKHELKHYANIAIGAGSAAAAIELLGLVFSCVLLSSIRRKEDEEALLRDARAYNQTAYNTVPTQPVRFSAGPVFGWCNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3L9</accession>
    <name>A0A0D2X3L9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346856.1">
        <property type="nucleotide sequence ID" value="XM_004346806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3L9"/>
    <dbReference type="STRING" id="595528.A0A0D2X3L9"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3L9"/>
    <dbReference type="OMA" id="ASNWVIM"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3L9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF239">
        <property type="entry name" value="ANNEXIN A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="315" mass="34272" checksum="8506ECB8ADFBC247" modified="2015-04-29" version="1">MPGTVKAAANFNAEADAQALYKAFKGIGTDEKAVIAIVANRSNAQRQQLKIAYKQAYGEDLVGRIKSELSGNFENITVALFNTPAGFLASELRKAMKGAGTDEAVLIEILCSADNNTIKAITAAYKEQFSRDLEKDVVSETSGHFRRLLVSLLTAHRDESTTVDAAKAKADAQDLYSAGEGKWGTDESKFNMLLGSRSYPHLRAVFKEYGAIKGHAIETAIDKEFSGDIKKGFLTVVAAVQDPAAYWANRMYLAMKGAGTDDDTLVRAIVSRAEIDMEEIKVSFIGTHKKSLLNWVQSDCSGDYKRMIEAILGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4B7</accession>
    <name>A0A0D2X4B7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4B7"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4B7"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4B7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="215"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="481" mass="53935" checksum="457F072245420878" modified="2015-04-29" version="1">MMLRRCRRPTIAVAAALCIGILVILALAIGSGWRLTLLEGAPAIDTPTTTTMRIYSEQGVAPFQCTPLSASAPRSLRIFVYPLPAEFNTRVIEHNLAHPPDMRDPVCTTSFYSSEWAFHQLLLDSPLRTLNPRDADYYYVPVYGTCHGFNRMAVQPNASAELFSAALDWITSHGSIPRDTLPWRYDPYSPDWNSLGTIEQVATRGEYPPFPAFAQDHLWLFSQGHGAKLFGDYSRIKNAVFLTANGQLSAAEFTLAKDVTIPPRLTHYVPTPIYANKSVDELEVILTGQRPTLACFGGTKLPCFVNDARGSCHSRGVRPYLKETFSKHPDFRILGIRSSGYEKALRSSTFCLCPEGWHAWTPRVFEAILSGCIPVLISDDLALPFESLIDYDAFIVRIPPARVAADLLSTLQSISHQDVVRRRRAMAAVWGRFVWHDVSQHGDAFCSILEQLYLKKRQASRRWADQKDVEFRRWVEAGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4G0</accession>
    <name>A0A0D2X4G0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345119.1">
        <property type="nucleotide sequence ID" value="XM_004345069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4G0"/>
    <dbReference type="FunCoup" id="A0A0D2X4G0">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4G0"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4G0"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4G0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="133" mass="15440" checksum="AC3340EA1253E8CB" modified="2015-04-29" version="1">MVASANRVKIVKKRTKRFIRHQSDKYACVAQSWRKPKGIDNVVRRRMHGTYVMPKIGYRNNHKTRHLLPDGFRKFTVANLKELEVLLLHNRTFAAEIAHNVSSRNRKAIVERAAQLNIKVLNANARLRTEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H5</accession>
    <name>A0A0D2X4H5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345191.1">
        <property type="nucleotide sequence ID" value="XM_004345141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H5"/>
    <dbReference type="STRING" id="595528.A0A0D2X4H5"/>
    <dbReference type="MEROPS" id="S14.A02"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4H5"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4H5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="257" mass="27673" checksum="C95ECE7949786034" modified="2015-04-29" version="1">MSRFQHLVQAAVHSAVAQAPAAAALSSVLAATSSLSPMVAKSSSAGSPFYSYASPTVGAGVIPTVVENTGKSERWFDLFSRLLRERIICLMGPIDDSTASVIVGQLLFLEGDNPLKPIHMYINSPGGVVTAGMAIYDTMQYVQSPVSTICMGQAASMGSLILAAGAKGQRFILPHARVMIHQPLGGAQGQASDIAIQAREILKMREMLNRIYVEHTGQPLKRIEDATERDYFMNPEEAKEFGIIDQVIQKRDITVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4N1</accession>
    <name>A0A0D2X4N1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344309.1">
        <property type="nucleotide sequence ID" value="XM_004344259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4N1"/>
    <dbReference type="InParanoid" id="A0A0D2X4N1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="986" mass="103333" checksum="25AC90B160DEA99E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4V9</accession>
    <name>A0A0D2X4V9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4V9"/>
    <dbReference type="STRING" id="595528.A0A0D2X4V9"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4V9"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4V9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1039" mass="112355" checksum="3DE7D29E1626AB03" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X500</accession>
    <name>A0A0D2X500_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343912.1">
        <property type="nucleotide sequence ID" value="XM_004343862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X500"/>
    <dbReference type="STRING" id="595528.A0A0D2X500"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X500"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X500"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="281" mass="30709" checksum="2357A4E136799736" modified="2015-04-29" version="1">MASVAMSTVGVGRYIPQLRKLTLHYCRNSPSSIGMREYIDRNVVKLAQDNPAIVIQVLQRKGKHPYIEADFLAGASRTVGARNLTANEVEQSVERLRGLLGRKNIHLFNRQSTQNPSVQGTWQPFLNRLAFQPLEAVGRLDRVRTFARNPHTKSQMPSRLQRDIMLGQGEETEKLLIAERAAYDADPNLIKRQYPEGGFGTITSTFSSDRPLRRTLPAYIVKATGMESPSPVRSPAQIQELLAKARASAGSAKPAAPAAAKPAGGADPKKAPAKPPAAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X554</accession>
    <name>A0A0D2X554_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343531.1">
        <property type="nucleotide sequence ID" value="XM_004343481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X554"/>
    <dbReference type="STRING" id="595528.A0A0D2X554"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X554"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X554"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="38536" checksum="C04672E0745C4898" modified="2015-04-29" version="1">MASIDKSKIGWEHYADYGEGFHDRLATHWPEPREQLHAGGWRMTKRIALELNLADSEGAEGKHYLDLCCGEGASAIQLAKEYNCKITGIDIVEKAINRAKEQAKADKVEHLVTFVACNAFQLPFADGSFDAIFGQDPDALSHQDRVHIFRECLRVLKPNGRFVFFHHWIPGLGFPEDEAKAIDAKNEELKFLAMNNCNADTYLKDMKTAGFVIDDAEDIGDLAAAHLRGVALSHYKKNGKIGDAWLQNNLDYIDRGRRFGLWCTAHKEGSSQGNVRTSSFNANEPPAYTTTSTVTAEELAQAQGRIRALEMQLRSVDERASSAVAVASTLSVIAGVVVVAAGIRLYLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X567</accession>
    <name>A0A0D2X567_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X567"/>
    <dbReference type="FunCoup" id="A0A0D2X567">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X567"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X567"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X567"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="599"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="893" mass="99142" checksum="E9E7285780BE1E17" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X585</accession>
    <name>A0A0D2X585_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343099.2">
        <property type="nucleotide sequence ID" value="XM_004343049.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X585"/>
    <dbReference type="OrthoDB" id="14404at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1513" mass="163730" checksum="62FF79201AC665DE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5D7</accession>
    <name>A0A0D2X5D7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin family member 1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343314.2">
        <property type="nucleotide sequence ID" value="XM_004343264.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5D7"/>
    <dbReference type="InParanoid" id="A0A0D2X5D7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5D7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000021">
        <property type="entry name" value="kinesin-like protein KIF16B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="3"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="620"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="833"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1301"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1470" mass="158033" checksum="F92F3A9F05A5C316" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5T4</accession>
    <name>A0A0D2X5T4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_010221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346400">
        <property type="protein sequence ID" value="KJE98364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5T4"/>
    <dbReference type="STRING" id="595528.A0A0D2X5T4"/>
    <dbReference type="eggNOG" id="KOG1095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5T4"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5T4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="33786" checksum="4E3A0E5D85E3916E" modified="2015-04-29" version="1">MSAAEVTQSLRDGLVLGETLGSGAFGVVLRGRLPRALVPTDAQYLLHDPMQPVLEVAVKTIQANASEQSHNEFIEEARMVSQFNHPNVVRAIATLLEAEPHLCVLELLPYGDLRDVLKKSKKSNILWTESEFAYTLAQVASGLNYLESIRFVHRDIAARNCLVGHGLSVKISDFGLSRLLAQDTDYYRMEHKGRLPVKWMAPECLNYRTFTHQSDVWSFGVLAWETFSYGASPYGSMAGREILAVVEAGSRLERPENCPLNLFAMVQACWEMNPQARPRFAALSSYFTNLSVNQPVRDIGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZU4</accession>
    <name>A0A0D2TZU4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364974.1">
        <property type="nucleotide sequence ID" value="XM_004364917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZU4"/>
    <dbReference type="STRING" id="595528.A0A0D2TZU4"/>
    <dbReference type="InParanoid" id="A0A0D2TZU4"/>
    <dbReference type="OrthoDB" id="4445at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZU4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="97275" checksum="98080149F48DCE17" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0G6</accession>
    <name>A0A0D2U0G6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_000316</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365187.2">
        <property type="nucleotide sequence ID" value="XM_004365130.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0G6"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0G6"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0G6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20792">
        <property type="entry name" value="C1_cPKC_nPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05596">
        <property type="entry name" value="STKc_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="72"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="335"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="1286"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1063"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="874"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1092"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1069"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE88721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1403" mass="155748" checksum="9B359FFBC743C3F2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0U2</accession>
    <name>A0A0D2U0U2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RUN and FYVE domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365303.1">
        <property type="nucleotide sequence ID" value="XM_004365246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0U2"/>
    <dbReference type="STRING" id="595528.A0A0D2U0U2"/>
    <dbReference type="eggNOG" id="KOG4381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0U2"/>
    <dbReference type="OMA" id="THCKQCK"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0U2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="307"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="864"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="629"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="727"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="99996" checksum="98CECF024D26EF06" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U101</accession>
    <name>A0A0D2U101_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U101"/>
    <dbReference type="InParanoid" id="A0A0D2U101"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="62" mass="6966" checksum="840D1630A5F34C2A" modified="2015-04-29" version="1">MMQERFGSTPLIATATYCAASLTMMFANKAVLSVYKFDYQLALIAFQSEHRKLTLDKALLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U158</accession>
    <name>A0A0D2U158_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_000523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U158"/>
    <dbReference type="FunCoup" id="A0A0D2U158">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U158"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U158"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U158"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="221" mass="24580" checksum="125CF7F996F69DEF" modified="2015-04-29" version="1">MYIDDPVLDPNALAEANRNAIAPPSLAISQLASESQDALIEMLSNLLDQLISRNDPLPVAKLTHFHAKSPPQINIQLYLQRFAKYAPVGNECFVLLLVYLDRLVQRTGSIITSLNIHRLLLTAILIASKFCQDKYYTNRHFSKVGGLPLNELNMLELEFLTHLDFDLNTSLDWLEKYYVQLRTHFQRKHGAPTAAAASAAYSTNGQYPTGNATIEASAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U394</accession>
    <name>A0A0D2U394_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365943.1">
        <property type="nucleotide sequence ID" value="XM_004365886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U394"/>
    <dbReference type="InParanoid" id="A0A0D2U394"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U394"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="735"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1020" mass="109487" checksum="E19C69636EA4F428" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4I3</accession>
    <name>A0A0D2U4I3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364304.1">
        <property type="nucleotide sequence ID" value="XM_004364247.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4I3"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4I3"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1178"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="845"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1178"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1404"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1425" mass="153183" checksum="C9668ADE532643A6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4U9</accession>
    <name>A0A0D2U4U9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364380.1">
        <property type="nucleotide sequence ID" value="XM_004364323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4U9"/>
    <dbReference type="FunCoup" id="A0A0D2U4U9">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4U9"/>
    <dbReference type="eggNOG" id="KOG3501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4U9"/>
    <dbReference type="OMA" id="REMIQQK"/>
    <dbReference type="OrthoDB" id="5242628at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4U9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13898" checksum="EFD95F889F06CC83" modified="2015-04-29" version="1">MDDELTKSFLELQGKIVETNRQLRVAHAQAEAAERAGVRASLTTKELAQLTPETRTYKSVGRAFLFQPVQQVLEELESVAAKSKVDVVKFQKSASYHERSLKDYEAQMRETVAALQKNQMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8P3</accession>
    <name>A0A0D2U8P3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8P3"/>
    <dbReference type="STRING" id="595528.A0A0D2U8P3"/>
    <dbReference type="eggNOG" id="KOG0220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8P3"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8P3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="280"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="531" mass="58507" checksum="C2508A7C6D39452C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBB9</accession>
    <name>A0A0D2UBB9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364171.2">
        <property type="nucleotide sequence ID" value="XM_004364114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBB9"/>
    <dbReference type="eggNOG" id="ENOG502SJ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBB9"/>
    <dbReference type="OrthoDB" id="17812at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF55">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="417"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="685" mass="73429" checksum="A62023D65BC4CE0A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBN9</accession>
    <name>A0A0D2UBN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBN9"/>
    <dbReference type="STRING" id="595528.A0A0D2UBN9"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBN9"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="271"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="790" mass="87884" checksum="C3712B542A3C766F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEB1</accession>
    <name>A0A0D2UEB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348079.1">
        <property type="nucleotide sequence ID" value="XM_004348029.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEB1"/>
    <dbReference type="InParanoid" id="A0A0D2UEB1"/>
    <dbReference type="OMA" id="YILHFVD"/>
    <dbReference type="OrthoDB" id="160470at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="598" mass="62984" checksum="3692C4FAB3F30C3E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF44</accession>
    <name>A0A0D2UF44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF44"/>
    <dbReference type="FunCoup" id="A0A0D2UF44">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UF44"/>
    <dbReference type="InParanoid" id="A0A0D2UF44"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="61773" checksum="436CC6D8F5CF583F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF52</accession>
    <name>A0A0D2UF52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_004476</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF52"/>
    <dbReference type="FunCoup" id="A0A0D2UF52">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UF52"/>
    <dbReference type="InParanoid" id="A0A0D2UF52"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF52"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE93726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="548" mass="59939" checksum="32FE5D30DD478AE1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH30</accession>
    <name>A0A0D2UH30_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH30"/>
    <dbReference type="FunCoup" id="A0A0D2UH30">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UH30"/>
    <dbReference type="InParanoid" id="A0A0D2UH30"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="216"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="382"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="596"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="650" mass="69898" checksum="C6C4637CBD66460F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIL4</accession>
    <name>A0A0D2UIL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Rhabdomere membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346190.1">
        <property type="nucleotide sequence ID" value="XM_004346140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIL4"/>
    <dbReference type="STRING" id="595528.A0A0D2UIL4"/>
    <dbReference type="eggNOG" id="ENOG502RTC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UIL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006031">
        <property type="entry name" value="XYPPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02162">
        <property type="entry name" value="XYPPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00239">
        <property type="entry name" value="RHODOPSNTAIL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="22379" checksum="7D653A52F79C1EBD" modified="2015-04-29" version="1">MSIPNQGAYPPPEYATAGSPPPQAGYPAPAGYPLQHQPSTGSTASAAPSYNAPPLEAKPPGYPPQQGYPPQGYPQSPSPPPGGYPQQYPQQGGYPPQQGGYPPQGYPPQGYPPQGYPPQGYPPQGYPPQGYPQQGYVQTTTTYGTNPAQQRQVVVIQDNRVNHPLHCLITFFFFPWIIVWFILCLAESSGPSVTTTTTTANGTQVVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL33</accession>
    <name>A0A0D2UL33_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344966.2">
        <property type="nucleotide sequence ID" value="XM_004344916.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL33"/>
    <dbReference type="FunCoup" id="A0A0D2UL33">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UL33"/>
    <dbReference type="InParanoid" id="A0A0D2UL33"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UL33"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="278"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="404" mass="42896" checksum="DCB045385BA649EC" modified="2015-04-29" version="1">MSSNRTVRLSITLSLTLSFFVVELVVGNMTNSVALIADSFHMLSDVLSLLVGLFAIRIAKHTLSSKNTFGWVRAEVLGALINGVFLIALCFSIFVDSITRFFSPEEIEDPRLVLYVGSAGLFINLIGMMLFHNHAGHGHSHGGGSEVAPPTETTSSTELQAGIFNSRQVTEVPVVADDGHGHAHGHGHGHAAAASAPSGGHGHSHGGSLNMRGVFLHIAADALGSVAVVISALVFEFADFDGKVYIDPALSLFIACLLLSHSIPLVKQSSMILLQSVPSTVNVETIKSSLVQLAGVVDVHELHVWELSEGNLIATVHITSDAEDSLAIVSQIKGFFHRFGIHSTTVQLEHVQNSYAVDDEKACLLDCSAADGVDDCSANTCCTNDNAVKARRTLRFPITTSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMK7</accession>
    <name>A0A0D2UMK7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type H(+)-exporting transporter</fullName>
            <ecNumber evidence="3">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006624</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMK7"/>
    <dbReference type="FunCoup" id="A0A0D2UMK7">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UMK7"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMK7"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="57"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="961"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE96281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="996" mass="107865" checksum="A66ADC007989E37E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNU2</accession>
    <name>A0A0D2UNU2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Essential for reactive oxygen species protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYBC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344532.1">
        <property type="nucleotide sequence ID" value="XM_004344482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNU2"/>
    <dbReference type="eggNOG" id="ENOG502S06T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNU2"/>
    <dbReference type="OrthoDB" id="10022724at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027846">
        <property type="entry name" value="Cybc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837:SF3">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15169">
        <property type="entry name" value="Cybc1_Eros"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="273" mass="29739" checksum="2457406E1A67B9AD" modified="2015-04-29" version="1">MSTAGQLRERRPGNTPATAATAATAAAASSSSSSSVMSPKTVGLGRTEQLARFGTYLNVTSCTATSVTLKHRPSARSWVTLGAFLSFGVLLFMFNPTTLFWRVVQVLFCAFLGVSNMELWEEVIVDKSAGQISMRRYNFIDWTRARYVVQIADVDEVIVGQHALGFGGFSQLCFRAELVLNTGAVVPLTDTYSLGQGKNVDKIVDFLSDFVGLEVDPNEEHTVRKTVRMRLEDDDAAATAAQQSSSDDESDPDEDQEAKYLQQRAADSLNATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP16</accession>
    <name>A0A0D2UP16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343716.1">
        <property type="nucleotide sequence ID" value="XM_004343666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UP16"/>
    <dbReference type="InParanoid" id="A0A0D2UP16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="341" mass="35735" checksum="CD887B53C0CA9EC1" modified="2015-04-29" version="1">MSKQSKRSQQLSSSSAGASAHTATTARSSSSSSSSSSSSAPLFDQAVAQFTADVPAAIVARWTTNGGRVKNLSKPSQQPSPDAVWTFALDLDSDGRIRQDLENGKLVYLDVNWISECVKARAVVPIDPFVFRLPLDEAVLNPLPARTYDPATSKPVYPQPSDSGSFALDEKTPLPPSWPWQEPGATRRTFAPPVQAAASKPGPVASPPASSDSQLASVQPQTQASASATQSTRDSASKAPLAAPPATPSTNASTATRKSADAGRQAAHPTAMEVDDAPPASKSAASLPVNIPATRKFQLPLDNAQDLPHVAISMDADELQDVAFLVHKQLRYVPGYSAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQB6</accession>
    <name>A0A0D2UQB6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343512.2">
        <property type="nucleotide sequence ID" value="XM_004343462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQB6"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQB6"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQB6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41147" checksum="175B013012536F44" modified="2015-04-29" version="1">MTERQRELYDQVNNASEKLVLHKKQIDDAGARAIAEAFKVNTTLKELDLYQNQIGDAGLQAVAEALKVNTTLTSLDLEENRLGDAGAHAIAEALKVNKTLDWLNLNKNQIGDAGAQAIAEALKVNTTLSSLHLGDNQIGDIGAQAIAGALMVNKQLWWLDIRFNFIGKAGLQAIGEARQVNRTLNRLLIDTQINPLVFSSRPRLATAEDLQNVFHLLSSGLALEDQPTSLPALPAEIAELIMDEAHYWQGVQHTKRSHFYDSPERILKVTLPQRIDGGSVRVKAIQVFRDMGNRFDSNGSSGFDLIIRNEQGAVQYEFSAKPTFVNSSLELVTILPANHPVIRQMRAGWQVQVRASKSSRDVQFESLYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URC2</accession>
    <name>A0A0D2URC2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270813.1">
        <property type="nucleotide sequence ID" value="XM_011272511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URC2"/>
    <dbReference type="InParanoid" id="A0A0D2URC2"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38614" checksum="E1770630B9F49D80" modified="2015-04-29" version="1">MSERQRELFDKVENACRALELDSRQIGEDEAWAIAEALKVNRTLNGWSTLDENQLGDAGARAIAETLEVNMTLNWLHLGQNQIGDAGARAIAETLKVNTTLTELRLYDNQIGDAGAQAIAEALNVNTTLTKLLAIAEALKANKRLSKLRLDSNQIGDGGASAIAEALKVNRTLTEIYLTQNYLTEVGVSALRRSGNTTCKLKDVDRQWTAVRAREYTESQPSLNSQRTAVRARKYTESQTSVTLPTETLRFRSELAAKNLELAAKDQMLATKDQMLAAKEQMLAAKDQMIAVKDQMIAAKDQELQQLRSELAVEGYDDDYDDDYDDDYDDDYDDDYDDIPKQEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT83</accession>
    <name>A0A0D2UT83_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT83"/>
    <dbReference type="FunCoup" id="A0A0D2UT83">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UT83"/>
    <dbReference type="InParanoid" id="A0A0D2UT83"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT83"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="371" mass="40357" checksum="D3C539A4E379C0FB" modified="2015-04-29" version="1">MSSLFFVSLEIEMSQPLPATHELHSGYFHPTLRSWQSNAAHLAASQLIYPLFISDVEDNWEEIGSLPGQFRFGLAHIDRVVAPLVAKGLRTVLLFGVPVQVPKDATGSLADADDSCVARAVRHLRKTYPSLLVACDVCLCPYTSHGHCGILYDDGTINNQASTERLAQVALSYARAGTSRENQHPPGILLTESAICVDAGCQIIAPSDMMDGRIASIKTALRGAHLHSKVSVMSYSAKFASCFYGPFRDAAKSAPAAGDRKCYQLPPGARGLALRATDRDVAEGADMLMVKPGGPYLDIVRDVKNKYPDVPLAIYHVSGEFAMLWHAAKAGAFDLRAAVLETVRGMRRAGADIIITYYTPQLLDWLQDEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF78</accession>
    <name>A0A0D2VF78_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF78"/>
    <dbReference type="InParanoid" id="A0A0D2VF78"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="617" mass="66081" checksum="E76895CE0C10844A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFU9</accession>
    <name>A0A0D2VFU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFU9"/>
    <dbReference type="FunCoup" id="A0A0D2VFU9">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFU9"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFU9"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="746" mass="81007" checksum="20C9D7403D98BA3B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG50</accession>
    <name>A0A0D2VG50_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG50"/>
    <dbReference type="InParanoid" id="A0A0D2VG50"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="12495" checksum="61D1E99EF4D6CD02" modified="2015-04-29" version="1">MSSSNPMFGRPAASFFSTFSWMILAAIAALIYSSTKAKSSPVNQDRFIARRAEVRGRGIKREAGCRNGSGDRLPLQHQTSLVLHNIDVERHIALVFCFCFFFFFFSSIPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHX4</accession>
    <name>A0A0D2VHX4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365862.1">
        <property type="nucleotide sequence ID" value="XM_004365805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHX4"/>
    <dbReference type="InParanoid" id="A0A0D2VHX4"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHX4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269299" evidence="2">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="22733" checksum="15548A361C8565AE" modified="2015-04-29" version="1">MKYSRSVAFMPLCIVLALVAISQPAVAADVAFGTFTDSTCTTHTTGNPSFKVASGDCKTSVVLGSNYRVVINSASSLTYQLGCDATCTTCTQTTTVAPGVCVDAGSSHYVTAHPLKYTSITVDSGTTCSTTSAVTVNSGACTANPMGGYMNIMDLGMGNVWFNMNCNVFCDQCKNLGSAVAGSCGPLEIGFGSFHINGSAALTASVTLIGMAVALLSAFTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI81</accession>
    <name>A0A0D2VI81_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365944.2">
        <property type="nucleotide sequence ID" value="XM_004365887.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI81"/>
    <dbReference type="STRING" id="595528.A0A0D2VI81"/>
    <dbReference type="eggNOG" id="KOG4830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI81"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17332">
        <property type="entry name" value="MFS_MelB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="624" mass="68664" checksum="AE1AB49FC35CC1C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIW2</accession>
    <name>A0A0D2VIW2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIW2"/>
    <dbReference type="InParanoid" id="A0A0D2VIW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="384" mass="40850" checksum="8D815CCE9B30C21B" modified="2015-04-29" version="1">MGVFETGLGVAAIVYFLRPKGSSTIAYLFGNGLGKGVGLIRRARTTIEAVAKETKAANKDTSNADGAGGVVGATAGASSGVMAALTAGARATLNNPLTPAVAPPQPIPEDADWSTLWWEFNRIRYEIRFESMFRSPTFMARRALGMDAMAQTPSSLSAASPTGTANPASGPPGNHSYTSSSLHGAGPAQESDYEFGPPANVTQPPSTPVTSFAQQQQQQQVQPSAQIPPALSRNPTPSATPSATPSATTAVTTAPTWTAKQLSDVNAADRLALFSGHSPLNVKVHSDQQRGGADIVAGFLTERSLTLRKRELMEQERRRVEAENASRPNHQNTLYRSLTQQLSQLVRKEAREDLLIGGERFYLLQVRPVPPLVPMPAAAQQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJR4</accession>
    <name>A0A0D2VJR4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364449.1">
        <property type="nucleotide sequence ID" value="XM_004364392.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJR4"/>
    <dbReference type="InParanoid" id="A0A0D2VJR4"/>
    <dbReference type="OMA" id="NICKTAN"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="845"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1333" mass="135969" checksum="1B8A6A247717E708" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKP0</accession>
    <name>A0A0D2VKP0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Akirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364759.1">
        <property type="nucleotide sequence ID" value="XM_004364702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKP0"/>
    <dbReference type="STRING" id="595528.A0A0D2VKP0"/>
    <dbReference type="eggNOG" id="ENOG502SGVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKP0"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKP0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29389" checksum="DAA0B3DD698548B4" modified="2015-04-29" version="1">MSTALASKRRFDAVDASPPSSPSGSAGGFGVASHYQHNSSPTLGRRLGMMTAAATTMPAALPYGIDDVSSSMLGHSLPHTSTHMPQGPLGGGMALTSSASSLAMASAAASPLFRQASSQYLSSSSSPAAAGQAPHQQLSKRSRQMDGSNNGPVSPMFASMQLISRRSHDSAFASSTSSDPVDKYIAGSKRVRNHIQEDASVMRPPPEEEQQYFTLSEVKSILERALEDRENQLRAEYDITLQQKLSEQFNSFSKFNEDHIHRQLKESTWSYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKT3</accession>
    <name>A0A0D2VKT3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364803.1">
        <property type="nucleotide sequence ID" value="XM_004364746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKT3"/>
    <dbReference type="STRING" id="595528.A0A0D2VKT3"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKT3"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKT3"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="23146" checksum="CA51FE90BA5AA3C3" modified="2015-04-29" version="1">MLGSTIARRALTTSAQSVRLAAATAASNAGSAPRVRNLPSHVKIVEVGPRDGLQNEKQLVPTAAKVNLINQLSHSGLKVVETTSFVSPKWIPQMADHAEVMASIERVPGVSYPVLTPNIQGFEAALAAGAKEVAIFGAASEAFSKKNINATIDESLKKFQVVVDAAKKHDIAVRGYVSCVIGCPFDGAIDPAVVARVAKKLADMGCYEISLGDTIGVGTPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN36</accession>
    <name>A0A0D2VN36_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349490.1">
        <property type="nucleotide sequence ID" value="XM_004349440.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VN36"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN36"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1537" mass="164925" checksum="97EBB604001985EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP34</accession>
    <name>A0A0D2VP34_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364001.2">
        <property type="nucleotide sequence ID" value="XM_004363944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP34"/>
    <dbReference type="FunCoup" id="A0A0D2VP34">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VP34"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP34"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP34"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="236"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="453"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="838" mass="91629" checksum="737EF0A6E250C16E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPE5</accession>
    <name>A0A0D2VPE5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPE5"/>
    <dbReference type="STRING" id="595528.A0A0D2VPE5"/>
    <dbReference type="InParanoid" id="A0A0D2VPE5"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPE5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253770" description="THH1/TOM1/TOM3 domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48536" checksum="B75742A1C1E88CCF" modified="2015-04-29" version="1">MSGQSNHPLDWMSRTCRLLYLLVDSLTAWRLASFPVPCCSMQNRCQCSHSTSTSLLFHHHYCYYSLSPCVSACPRSAVAIVAMSVANPLGTLLWQTSNAIHTSAADAPLHSILTPVNNCDRVCPNAIGSGQWSLWVLAVLYYFIAVGSVSLIVSRCLAVRSLQLTSFRSIFLVLAFCFSFLRGVLVTFNFSWVVISLIFVGQLLPVFFQFAMFSLLIVFLAKCQYMMQDNDSIIRKFLYPIYIGILVVFFLISVIMAFIIAENNDPDDHRVLTRGFDRDIAIYSSIVFGTLFILVCTYGYRTYKLVLIFSLSKKKERKVRRFAMVALLYLVVLVARVLWDVTYLAGINIAQQQMNDMIIDSNNDYFICMLVFYFVVDIVPTGAILLAFYCWLPNRPAAEITVTETQRSMYGATPGYSTFGTNHDEPGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRR3</accession>
    <name>A0A0D2VRR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_004351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348179.2">
        <property type="nucleotide sequence ID" value="XM_004348129.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRR3"/>
    <dbReference type="STRING" id="595528.A0A0D2VRR3"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRR3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="724"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="547"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE93587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116294" checksum="E678B199C42AECCB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRU3</accession>
    <name>A0A0D2VRU3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348214.1">
        <property type="nucleotide sequence ID" value="XM_004348164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRU3"/>
    <dbReference type="InParanoid" id="A0A0D2VRU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="524" mass="56399" checksum="F3BD4F484695918B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRX0</accession>
    <name>A0A0D2VRX0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348279.2">
        <property type="nucleotide sequence ID" value="XM_004348229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRX0"/>
    <dbReference type="InParanoid" id="A0A0D2VRX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="24165" checksum="26885B4A0DE76931" modified="2015-04-29" version="1">MAQIAAIAGARQQREQYRATGLAQTLPTSAQSSAAAIAASAGRGGGLPSATEIEAAQQSHALERQSHAVSETDRATLHHVLEPFSQHIGGNESKHLNASSSSHRSDLASKWYAELSRLARIEERSDSNHNELGIPSQRLCCNVRWSNSSSSSLEWCTRHCNMSLQLRLVDGPDQTLIPSTSFSCELETITAETIPMDYIQTKIWPVIQSTAASTTRRTTKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS51</accession>
    <name>A0A0D2VS51_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS51"/>
    <dbReference type="InParanoid" id="A0A0D2VS51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="346" mass="38125" checksum="994303ECCE30DC63" modified="2015-04-29" version="1">MLLLVRERRKDESSSDSDDSEDDEQRLRFAEAAVTASVLKTPSHRADRSGAMGASGSVTGGASNSRNGTLDNTQCIDIDRPKHDIHVRLHPAEMQFRSAAIATATQLRLLLPSGAGAAPQPVSLRSEVYDQDSYNPGRMWAQNDKEFHKHAYTRLSKMLDETCGAAITPNLWEKTLPWLKDRKAAASPKDQSSDSMKFISGLPGAPSLTVLPYSSLSSSLKPVPTPDPARASVKRTHSSRHGNDDESSDEDETLTRMREAAIPTESILSQASFQKQAAAEVGSLWYPMLEFDGDFMQAFQNQTLTENAHSRVGNEKKKLKKEKKEKKDKGDKKDKKDKKAKKGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSQ0</accession>
    <name>A0A0D2VSQ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2VSQ0"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSQ0"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSQ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="351" mass="38396" checksum="39A767649D6FA9D8" modified="2015-04-29" version="1">MITVRPGLPKDLPAVLGLINELAVFERCGKEVETTVEQMHRDAFERPEPVFRFFVAIDTSAASATAGSNAPQQASSSAAEDGTVVGTAIYFYTYSTWKGRCLYLEDLVITESRRRQGIGRHLFDAVMAQAKQDDVARVMWQVLDWNEPAICFYKSLSADLDSTWVNCRLASNKKRPASLSTQAAASFQSSQVNQQPAVAASAAAVSDEVRAQVQEAFELFNSSGRDAIDEKELELALSALGIDITKEAAKKLIADVDTEGSKTIKFADFSTYAIARLSERSIDDEIIKAFRLFDPENTGRITAKNLKHIATVLGEEASDQLLQDMIAEADSTHTGSVSQADFVRILKRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSX5</accession>
    <name>A0A0D2VSX5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSX5"/>
    <dbReference type="STRING" id="595528.A0A0D2VSX5"/>
    <dbReference type="eggNOG" id="KOG2939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSX5"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="823"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118643" checksum="17147F269D9A43BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU80</accession>
    <name>A0A0D2VU80_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU80"/>
    <dbReference type="STRING" id="595528.A0A0D2VU80"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU80"/>
    <dbReference type="OrthoDB" id="6435754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="183"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1261" mass="141973" checksum="49B79DBC4C8C3950" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUE0</accession>
    <name>A0A0D2VUE0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346200.1">
        <property type="nucleotide sequence ID" value="XM_004346150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUE0"/>
    <dbReference type="STRING" id="595528.A0A0D2VUE0"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUE0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253892" description="RING-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="116383" checksum="5B11AC20A63A5A33" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUZ6</accession>
    <name>A0A0D2VUZ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUZ6"/>
    <dbReference type="InParanoid" id="A0A0D2VUZ6"/>
    <dbReference type="OrthoDB" id="6347918at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40998" checksum="61F11418EB8D2942" modified="2015-04-29" version="1">MLSYQNMTPSQRELYDKVKNTTHYFYVSWEKVGDAEALAIAEALKVNTTVTRVELWQNQIGVAGASAIAETLKVNKAVTSIAVWDNQIGDAGASAIAETLKVNKTVTWITVWDNQIGDAGASAIAEALKVNTTVTKVDLGENLIGDAGAQAIAELIKVNKTLAWLNLSWNCIGDVGIQAIADARESNPTLTDFYISLQLSPLVPSSFPRLATADDLQAVFGLLTSGRELEDQLASLPALPTEIADLIMDEACYWQGVQRTNRACYFDSLSVTVPKSSTGNSIRVKAIQVLLDANDSEPCVVKLIVRDTQGAVQYECTAKPTLVDSTLWHVTILPANHPVMRQMREGWKVDVQPRKSSRGVRFESLHVGYIERQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYB1</accession>
    <name>A0A0D2VYB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase CAOG_006971</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343695.2">
        <property type="nucleotide sequence ID" value="XM_004343645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYB1"/>
    <dbReference type="FunCoup" id="A0A0D2VYB1">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYB1"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYB1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="264" mass="29360" checksum="E4B7F1BD73841785" modified="2015-04-29" version="1">MADDAAEIAPEPSKLGTREYWDQVYEREVGNFDERGDVGEVWFGMDAVESVVDWIQDDARLPKHLSVVDIGCGNGVSLVELARVGFKSLLGIDYSEPAIELARKVAAADELDIDYQVFDFINDDVSALQNDKNRFPFDLCIDKGTYDAISLAQNSASARAAYVRQVHALCSQAVKPRPPSDDDDENADEEEEDDDDDRRRKLSPRTTGLFIITSCNWTNDELKAAFASHFTTYAVIKYRVFEFGGKKGSSISTVIFAPKPPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0F6</accession>
    <name>A0A0D2W0F6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342852.1">
        <property type="nucleotide sequence ID" value="XM_004342803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0F6"/>
    <dbReference type="STRING" id="595528.A0A0D2W0F6"/>
    <dbReference type="eggNOG" id="ENOG502SA9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0F6"/>
    <dbReference type="OrthoDB" id="5203190at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0F6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03143">
        <property type="entry name" value="A4_beta-galactosidase_middle_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021655">
        <property type="entry name" value="Put_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11617">
        <property type="entry name" value="Cu-binding_MopE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254032" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="400"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1103" mass="116133" checksum="4F8C95CDBCF5A939" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIZ6</accession>
    <name>A0A0D2WIZ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIZ6"/>
    <dbReference type="eggNOG" id="KOG3879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIZ6"/>
    <dbReference type="OrthoDB" id="72976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="486" mass="54160" checksum="07D8DAE1EA5B411A" modified="2015-04-29" version="1">MKVNPSRLVVHGALTIVSVVMPMRIEGLLKCDWWYIFMPLLLWKAIAFVGAAVGAHAWLSDVRLRKTVELLRARQQQQQGYQPPPVLLDSQHHHTGGLLPSTPAAAAAAAAQPPQPGASSQAAAILTSRHVPLPHRATTQLREMPPSEAYTTDREQLARNWRGSGDQEEQVLPAVSSADWSRAEALLRLTDRQYQVYVSEITSQFSTMLFLTIMLGLLLGAEIVICLNLNSFDSVVNNRPERLLMPWWCAFLPLCCTSFVALVSVVAQRRRSGSALPLLEITFIALFFVFLVVGLKLDGWINWSWPIVYIPIYGLLFIGSFILTMYMIRACIAIRRSRDHRAVAMEYTRLLVTALGALFILLLVKLNGHPLSTYEVFAPSTLMFLFLFSTGLVKQKVRGWWFGANVMESVWSDTMHDIVEEDELSDVDGTPERGYGTIATEISSALSGTANLIIDEDKRSIASESSLADFAVPPILSLDLYQLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJZ4</accession>
    <name>A0A0D2WJZ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJZ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WJZ4"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJZ4"/>
    <dbReference type="OrthoDB" id="6277409at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="46"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="225" mass="25572" checksum="CB075026053566BC" modified="2015-04-29" version="1">MFLRARKHNPTRAVELYKGFVAYRRKHSFPVRVDRSTGRFAKIPLDEHIERKLREELVVVLPHADKDGRTLIYYRPRNNNPSEWQLSLKAIWFVLERIVEQEQVQICGMTLLGDGEGAGLGNFSRDLMKNLIGSFQGAFPMRVGRIIIANQAAFFRVVWQLMSLFIKPKLLSRILVVGGNHDAVLDFIDHHALPTSVSGGLSTFHWHKWVDGHLVASPASPQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK76</accession>
    <name>A0A0D2WK76_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L35e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364753.1">
        <property type="nucleotide sequence ID" value="XM_004364696.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK76"/>
    <dbReference type="FunCoup" id="A0A0D2WK76">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK76"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK76"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK76"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="123" mass="14191" checksum="46E8F6D1DFDFA00E" modified="2015-04-29" version="1">MTKLRAYELRTKSKAELEDQLKSLKTELASLRVTKVTGSAANKLGRISAVRKGVAAVLTVMNQTQREHLRKHFAGKKYLPTDLRVKKTRAIRRQLNQHERSQVTIREAKKRTHFPLRKYALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKR7</accession>
    <name>A0A0D2WKR7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348915.2">
        <property type="nucleotide sequence ID" value="XM_004348865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKR7"/>
    <dbReference type="STRING" id="595528.A0A0D2WKR7"/>
    <dbReference type="eggNOG" id="KOG2482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKR7"/>
    <dbReference type="OrthoDB" id="278606at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="547" mass="61640" checksum="F0CC350BBB335513" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLB7</accession>
    <name>A0A0D2WLB7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364752.2">
        <property type="nucleotide sequence ID" value="XM_004364695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLB7"/>
    <dbReference type="FunCoup" id="A0A0D2WLB7">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLB7"/>
    <dbReference type="InParanoid" id="A0A0D2WLB7"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLB7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="297"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="776"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="973" mass="106336" checksum="5E2AECE100C1C0F0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMZ1</accession>
    <name>A0A0D2WMZ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMZ1"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMZ1"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1770"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2047" mass="219935" checksum="CE21CC7338EE86C0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN96</accession>
    <name>A0A0D2WN96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348377.2">
        <property type="nucleotide sequence ID" value="XM_004348327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN96"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN96"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="69257" checksum="EAF18DE40B3CA969" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNH0</accession>
    <name>A0A0D2WNH0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Golgi resident protein GCP60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNH0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNH0"/>
    <dbReference type="eggNOG" id="KOG3878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNH0"/>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF3">
        <property type="entry name" value="PROTEIN TMED8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52771" checksum="2C19A1D5FE9E3A6A" modified="2015-04-29" version="1">MAAEMAGEESASSAQALPIGGKATPSAPSSATTASEGGPQKYGRPLVEVYGLALQFLRQRRGFEKASRAPSDCAGDASSPDFAPLLCLLRNETSASAGASVIALAFVSGLQLAHSQSFLVALPYAEKNALFAYRKQVQHGTYAPEKMPDVGFFDFVGKDQRNAWQALGNISREEAMAGVIQILADSDSWTQFVTEAIAAKVEEERKAREQAEAEARELARQQEEERLKREEAVRQQQRLEQLQQQQAELQQQQLKQQQLQQQQQQQQQYSHPHPSQQASGHHGHSHDGDHHGHSHDGEHAHSHDLVHDHAHQTAETLDAAGEKLAAHQRFVEAVRGDPDSVLVIGRGETATVRLTVGSDAPSTPSPSAVNGNAVVSTIAPADAANSSNGSDVPPPVPKKWHTTWEFATESYDIGFGVTFETNSFSHTAVTPILPTLRSESNLQVVRGAHTTDLPGVYLFKFDNSFSVFRSKTLYFRLYTQPLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPN6</accession>
    <name>A0A0D2WPN6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during skeletal muscle growth protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348043.1">
        <property type="nucleotide sequence ID" value="XM_004347993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPN6"/>
    <dbReference type="InParanoid" id="A0A0D2WPN6"/>
    <dbReference type="OrthoDB" id="9435504at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01821">
        <property type="entry name" value="DAPIT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6163" checksum="661F37F0D4795C90" modified="2015-04-29" version="1">MAGGHGHGVEPQFQGIAKIFNSVTTAGRRNLVLATLSGVTLAILIGKSGGSKPVPADAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ53</accession>
    <name>A0A0D2WQ53_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348287.1">
        <property type="nucleotide sequence ID" value="XM_004348237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ53"/>
    <dbReference type="InParanoid" id="A0A0D2WQ53"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="12679" checksum="6E46B1253559620E" modified="2015-04-29" version="1">MVVFSELEEGVPMNEVFVKEITGEDGTGFRELYGKEVNRPITFVPFFSTNEIPQVTRDPALWRRLTNVQWSAMAEDQKPGVYKADPELKDLVKTKEYLESWLYWFIQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQP3</accession>
    <name>A0A0D2WQP3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347953.1">
        <property type="nucleotide sequence ID" value="XM_004347903.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQP3"/>
    <dbReference type="SMR" id="A0A0D2WQP3"/>
    <dbReference type="STRING" id="595528.A0A0D2WQP3"/>
    <dbReference type="InParanoid" id="A0A0D2WQP3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="580"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="79152" checksum="8046A15443B0F68F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR50</accession>
    <name>A0A0D2WR50_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR50"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR50"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="9">
        <location>
            <begin position="251"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1435"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1463"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1493"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1521"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="839"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1628"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="616"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="929"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1369"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1674" mass="177410" checksum="9A79845971416D03" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRD6</accession>
    <name>A0A0D2WRD6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cathepsin L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347256.1">
        <property type="nucleotide sequence ID" value="XM_004347206.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRD6"/>
    <dbReference type="STRING" id="595528.A0A0D2WRD6"/>
    <dbReference type="MEROPS" id="C01.092"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRD6"/>
    <dbReference type="OMA" id="EGETCCC"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRD6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018686947" evidence="6">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="108"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="325" mass="35001" checksum="1E039A197B64DF76" modified="2015-04-29" version="1">MKAFTAVALLALVACATAMPFAEWKALHNRQYASAQEEALRQEIYLSNLELINEHNAAGRHSYTLGMNEFGDLAHHEFAAKYLGVRFNGVNATKSFASSTYLPRMVSLPDSVDWRTAGIVTPVKNQGQCGSCWSFSTTGSVEGQHARKTGTLVSLSEQNLVDCSSQEGNEGCNGGLMDDAFEYIIKNGGIDTEASYPYTATTGTCKFNAANIGATVASYQDIITGSESDLQNAVATVGPVSVAIDASHINFQFYFTGVYNEKKCSTTQLDHGVLAVGYGTSTEGKDYWLVKNSWGATWGKAGYIWMSRNADNQCGIATSASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRV7</accession>
    <name>A0A0D2WRV7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRV7"/>
    <dbReference type="STRING" id="595528.A0A0D2WRV7"/>
    <dbReference type="eggNOG" id="KOG4278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRV7"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="769"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1072" mass="111889" checksum="BD7B3114BE1EA1D3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSM9</accession>
    <name>A0A0D2WSM9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_005118</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSM9"/>
    <dbReference type="FunCoup" id="A0A0D2WSM9">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSM9"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSM9"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSM9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000020">
        <property type="entry name" value="Hexokinase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="113"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="310"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE94483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="551" mass="58449" checksum="9A05A2C4E5B0C60C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSR6</accession>
    <name>A0A0D2WSR6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSR6"/>
    <dbReference type="STRING" id="595528.A0A0D2WSR6"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSR6"/>
    <dbReference type="OrthoDB" id="1600340at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSR6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270155" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="79291" checksum="07B59154E61458BB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU60</accession>
    <name>A0A0D2WU60_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345442.2">
        <property type="nucleotide sequence ID" value="XM_004345392.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU60"/>
    <dbReference type="InParanoid" id="A0A0D2WU60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="54098" checksum="905300F9045BBBCF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU73</accession>
    <name>A0A0D2WU73_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU73"/>
    <dbReference type="STRING" id="595528.A0A0D2WU73"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU73"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF84">
        <property type="entry name" value="REPEAT TRANSMEMBRANE PROTEIN KINASE, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="299"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="568" mass="61630" checksum="BEBD10EFC8BF33CA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUC7</accession>
    <name>A0A0D2WUC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MELT/VEPH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345547.1">
        <property type="nucleotide sequence ID" value="XM_004345497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUC7"/>
    <dbReference type="eggNOG" id="KOG3723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUC7"/>
    <dbReference type="OrthoDB" id="419186at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="642"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="741" mass="80811" checksum="30CF77D024949288" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUF7</accession>
    <name>A0A0D2WUF7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUF7"/>
    <dbReference type="InParanoid" id="A0A0D2WUF7"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="37488" checksum="5BC4172BDB6F763A" modified="2015-04-29" version="1">MLERAIHQGVEVIRVGLFPGRINTTVVRMPNCTTKMVLSVDVGTLTNAIGVLGLVLVVKLGTKCMFRTGSTLIDCGPPNQWSPVKAYLTSVQTSAQGLAPGGSAVQPVKELLITHHHEDHSGNAARIKRDFPSISIRAPKTSLKLLTEGFEVQMYRRLVWGKPPTVDVHGSFDAILADSASSASVPPPAIRPTIGHDLSIVPVAAPGHCSDMTVMFDPARGHLFSGDLFVTSKPLMMRNDEDVNDEIASLRRVLSLDWNTLFCAHRGFVSDGKKLLQQRLDHFLEMRAKATELNHQGLSHRAIASKLFGKEEALYYLSRGHFSKKHLVEGLLSAPHHPVPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUS9</accession>
    <name>A0A0D2WUS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUS9"/>
    <dbReference type="FunCoup" id="A0A0D2WUS9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUS9"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUS9"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="270" mass="27675" checksum="B38EFD16E9E2938A" modified="2015-04-29" version="1">MSGSAVGGGGGAAAGGSRSDAFAGLASLSAFSGSGYTPSAAKGNASHMSVAIPMDGNSSSSSSGFAGQLSAMVFGGSNNGASATSTQSGNGTSTGSNASSASNDDASFVLGNSALYGGSNESCMELSRTQRAIGFVLFLAAGAFCFALSFLYTPMLILKARQFALMFSLGSVFVLTSFFILVGPVTQSRRLIASERAPFTAFYFFTLFITIYSALIWQSFIYTIVFAGLQVAALVWYVISFVPGGSVGLKILGRFTFKAVRTTAQAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV36</accession>
    <name>A0A0D2WV36_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CEBPZ CCAAT/enhancer-binding protein zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345105.2">
        <property type="nucleotide sequence ID" value="XM_004345055.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WV36"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV36"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV36"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="797"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1321" mass="145996" checksum="9B3F26241E7E67C8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVH1</accession>
    <name>A0A0D2WVH1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270666.1">
        <property type="nucleotide sequence ID" value="XM_011272364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVH1"/>
    <dbReference type="STRING" id="595528.A0A0D2WVH1"/>
    <dbReference type="MEROPS" id="S10.005"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVH1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVH1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006514782" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="493" mass="53696" checksum="2653355F3E6F9D31" modified="2015-04-29" version="1">MMRFQSSVLCIALVALAIAAANADDRIVNLPGLPASLANLEMYSGAVVVNATHQRSLFYMLAMSQGDKNSDPLVAFLNGGPGCSSLGGGMMSECGPFFPDANGNLLENPNSWNKIANLLVVESPSGVGFSTSQNTADYNTGDVQTAQDWLAFLLIFLAKYPQFANRPFHIAGESYGGHYIPQLAKAILDSNAAGINPKINLVSYMAGNPWTDTTIDNMYTAQSWWARAINSYETWNGMATYCDFGKIGPLAALEVAQYNAPDPLKCQKFVTASTNEMGNIDIYEIYQDVCLAGPDGRVGARNNHGAHLLKALAKGPDAHLTILGHLGRRILEAEKSRPQKLRRDPPVEPCIDDFVQTYLNRADVQAAIHAPTLSYGWMDCSNIVNYSYNDLLASVLPLIQTLTKSGIRMLMYTGDHDGIIASLATTTNVRALNLTVVQNWRPWIGSDQQVAGFVETYNGMTLATVRGAGHMVPYIQPARAFDLFSRWVNNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVW8</accession>
    <name>A0A0D2WVW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344429.1">
        <property type="nucleotide sequence ID" value="XM_004344379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVW8"/>
    <dbReference type="InParanoid" id="A0A0D2WVW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="170" mass="18914" checksum="F8D19CA6F888ABC2" modified="2015-04-29" version="1">MHEAWYKWSEATKAAAQSSSRPFKMEHHYHARPRGRFGLGIVLGTVIGVYVAQNFQVFRKRDGDAAATSCHRSQPPPLPPPSPAQQQSVATAAATAHEWLDAMHERVGRWEQWHQQHHQQQQQQHHQQQQQQQTASAPSPSEATITNSSAVPQTITIPPGARVVITSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWV0</accession>
    <name>A0A0D2WWV0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWV0"/>
    <dbReference type="FunCoup" id="A0A0D2WWV0">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWV0"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWV0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWV0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="458"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="234"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="555"/>
            <end position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="824" mass="89567" checksum="9F8DD9C88DB826B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWX0</accession>
    <name>A0A0D2WWX0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343459.2">
        <property type="nucleotide sequence ID" value="XM_004343409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWX0"/>
    <dbReference type="STRING" id="595528.A0A0D2WWX0"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWX0"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270247" evidence="5">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="78"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="499" mass="54757" checksum="EFF06C4AFD657438" modified="2015-04-29" version="1">MKGLLALGLVVLVVAVGLQALVQQPSLGQQATNALLSLKAPPPELHAPGWALKIGEIALGLMDWLTVAAKPAPLRAFEAMFGFGLTQALAAMARLEVFDGLAEAGANGATCGELIGWLRNRKPSQIRRQPVNAQLLCRLLDFAAANQFMNKDQATGKFYLNDFSVLFTQNDDNVGSLVPMLLYHADEVNYGWTRLSEGMRQVYPAFELANGENLENYYNMNPEKRGNFDLAQRSISADFAPKMLAKYGDEFKQFAQVHGRSVHICDIGGGIGSVAEGLLREFPDATATVIDLAHKETQANNYIEQVQLKDRIRFVAGDFSKPLSVECDYYLLNHIIHDWNDTMAVNILSHVRTSMPSHAKILLVEPVLETRNAYFERLKRFVDMQLLVVFQRGKARSTREFTSLLSSSNLELSRHVPLCGLFDIVEAVPVDATSKVITPETAAPVVETPAASTSSKPRKQKQREQKQQQEAEAAETHKATPAVAAEEAASSETPAPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ3</accession>
    <name>A0A0D2WWZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343510.2">
        <property type="nucleotide sequence ID" value="XM_004343460.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWZ3"/>
    <dbReference type="InParanoid" id="A0A0D2WWZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1334"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1565"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1784"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="538"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="751"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="860"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1439"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1582"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1664"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1703"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1809" mass="196535" checksum="A9E8663B5E320F55" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX61</accession>
    <name>A0A0D2WX61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342873.1">
        <property type="nucleotide sequence ID" value="XM_004342824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX61"/>
    <dbReference type="STRING" id="595528.A0A0D2WX61"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX61"/>
    <dbReference type="OMA" id="DEPLAYN"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF10">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113019" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="128"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="425" mass="47371" checksum="B52E74AD595C4035" modified="2015-04-29" version="1">MQSRHSVVALLVLLLGTCALGAKLEQVHIAFGDTPSAMTVMAASDAMPAAATVLYGTSATALNMNQPASDVRFFTAGNELGLQYHLVFKLQKLVPDTLYFYQVRTDTNATAVFHFVAQNDNLDHPANFLVYGDFGLPKGGFTLPRLVAETKTGKFDAAIHVGDFAYDMFDHNGTRGDNFMNQVQQYAAYLPLMTAVGNHETAFNFSHYRNRFAMPGNGAASDNMYFSWDMGRAHFIAYSSEVFFTNGPVQDQYNFLKQDLIAANANRAERPWIIAYGHQPFYCSNLDHDDCTTSRSVVRAGLEDLFFEYGVDLVIEAHEHSYERLWPVYNETVTQHDYINPRAPVHIIAGVAGCNEGETTCINPILGSKGPWSAFRTAFLGAYGYGRLEITNSTHLHWEQVLDITRTDLDQMVIVQENHGPYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXE8</accession>
    <name>A0A0D2WXE8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270803.1">
        <property type="nucleotide sequence ID" value="XM_011272501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXE8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXE8"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXE8"/>
    <dbReference type="OMA" id="RACNAYS"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXE8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="197"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="652" mass="68671" checksum="6C0D86AC87BC42C2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY20</accession>
    <name>A0A0D2WY20_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptophysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_008250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homohexamer or homotetramer. Interacts with SRCIN1. Interacts with VAMP2; the interaction is inhibited by interaction of VAPM2 with SEPT8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
            <location evidence="15">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342419.1">
        <property type="nucleotide sequence ID" value="XM_004342370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY20"/>
    <dbReference type="STRING" id="595528.A0A0D2WY20"/>
    <dbReference type="eggNOG" id="ENOG502QT4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY20"/>
    <dbReference type="OrthoDB" id="10006326at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF10">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="19">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE98260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="17865" checksum="3DBD4FFFDA70C7E3" modified="2015-04-29" version="1">MPNFSIFKEPRGFIRIIQLIFAIIAFAAAASEECGAKFSDFGSGKEKDRFAFFIATGVIAFLFDLAILVVYAFLLESLPPVTVMAELGFTALWSFFWLLASSLLADTVKDISDIPGCEPSSWQAAVVFGFINLICWVANIYYLFKETKAAPPVTNPADSGPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY23</accession>
    <name>A0A0D2WY23_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342941.2">
        <property type="nucleotide sequence ID" value="XM_004342891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY23"/>
    <dbReference type="eggNOG" id="KOG4682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY23"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY23"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18495">
        <property type="entry name" value="BACK_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="813" mass="89024" checksum="B3D7442F7F3B7F96" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYH8</accession>
    <name>A0A0D2WYH8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYH8"/>
    <dbReference type="STRING" id="595528.A0A0D2WYH8"/>
    <dbReference type="InParanoid" id="A0A0D2WYH8"/>
    <dbReference type="OrthoDB" id="2519628at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270272" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="48"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="994" mass="102555" checksum="8E615815AA423C0B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X083</accession>
    <name>A0A0D2X083_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365110.1">
        <property type="nucleotide sequence ID" value="XM_004365053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X083"/>
    <dbReference type="InParanoid" id="A0A0D2X083"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="552" mass="59289" checksum="2A80059CF4AB9193" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0C5</accession>
    <name>A0A0D2X0C5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365271.1">
        <property type="nucleotide sequence ID" value="XM_004365214.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0C5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0C5"/>
    <dbReference type="eggNOG" id="KOG4605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0C5"/>
    <dbReference type="OrthoDB" id="15717at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="635" mass="67760" checksum="557461845C24FAEB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K3</accession>
    <name>A0A0D2X0K3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365599.1">
        <property type="nucleotide sequence ID" value="XM_004365542.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K3"/>
    <dbReference type="STRING" id="595528.A0A0D2X0K3"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0K3"/>
    <dbReference type="OMA" id="NMNHASV"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0K3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="506" mass="55627" checksum="CA1CB04583E04AF2" modified="2015-04-29" version="1">MAFYQQGQRTSALPWPVAGSSSTVAAPIEVTPTTAASLALWHTSLLPSTAQPSSPSSSSSSSSSPPRPRLRMHSDAAAAADEQQQDGSPTPFALAQSSSPVPGAHHHYHHHHYQQQQQQQQQQQQQQQQQRVSFLPQPPSRPTSQTGSTLPPPPEQQHFDRSALASATSMLAAFAFEQPPVVDWHFANYVAAHPRPSTIQHWQLRHLVAALSDEEVVVVYKGDVELYNTKTRKSRTLFKTSYSPTALDVNHGYIATCGQEGQITIYSIEDSTVIHDSFIIHNVLNAVHISRYEDEVRLIVPSNDSNVHVFLLPSLQPICTIPCNTAINFAAVSPDGSKMTLVGDCNEVYLYSIVGHDYTRVARFSEARDHGFSCSWHSSSTVFAAGSQDGLVAVWDIRYSKALAKLHSTQRGHIKGAVRNVKFSQKSTVDLLAFTEHVLYAHVVDARTFSQQHSIRLPAPGSADCVIAGLAFSPSNEHMFVGTDSLLTEYRLDTFRRRSFACGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0R9</accession>
    <name>A0A0D2X0R9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365859.2">
        <property type="nucleotide sequence ID" value="XM_004365802.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0R9"/>
    <dbReference type="STRING" id="595528.A0A0D2X0R9"/>
    <dbReference type="eggNOG" id="KOG1489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0R9"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0R9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="499"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="630"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="891" mass="95605" checksum="4D6BDE8319B5EEA1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0X3</accession>
    <name>A0A0D2X0X3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0X3"/>
    <dbReference type="STRING" id="595528.A0A0D2X0X3"/>
    <dbReference type="InParanoid" id="A0A0D2X0X3"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0X3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="588" mass="63857" checksum="2A974ADA4B55C5D5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1E2</accession>
    <name>A0A0D2X1E2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364797.1">
        <property type="nucleotide sequence ID" value="XM_004364740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1E2"/>
    <dbReference type="FunCoup" id="A0A0D2X1E2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1E2"/>
    <dbReference type="OMA" id="YRNVKNH"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1E2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="149" mass="16805" checksum="EBE9BCE7439E3F2C" modified="2015-04-29" version="1">MSSTEPAATESEPSAQQQEQQQQQQQQQAVIITVRCIRSFEHRALKSLVLHGVDLAHTSGGDLMALVKQRIQTAPGFAPFRAIAYDTIKIHSQAFGAKTNNPIINLDHDDWVLDPARTLHEQGVKHETELSMYRLEDYNTYKAHPSTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1I6</accession>
    <name>A0A0D2X1I6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid 5-alpha reductase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348861.2">
        <property type="nucleotide sequence ID" value="XM_004348811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1I6"/>
    <dbReference type="FunCoup" id="A0A0D2X1I6">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1I6"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1I6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="52921" checksum="75D423E471B80F44" modified="2015-04-29" version="1">MDALRGLASQIAVLVVPASPPPSTPGDSGSLPPLDALLEQLLSTRLGVAIAAAAFVGACSGIARVMLANSLPAVVGGVQVPATTPPPPSSTPTSVSPAAAAAASGPAAVGDAAAPISSSGGLITAVAFSPFHLAAWATEQAAKAVARVAAAPNGQVGATAPAASADAVAAAGTGSGTSQLFSVIRAAIRGLLVPVHVVNSVRRAVHNAAFHGAKLLAAVLRQSLPSFSQVLENSPRLGGLLSLLCASSLLWLVSVRINDVSIVDPFWSLGFLILTAVFRNHRATATGFAGRKDLILLLVSLWAVRLSAYLFYRNYGQGEDFRYQAFRRRHGPKYWWVSLFQTFWLQSVLCFLVGFPLLTAQRGSAPMYFTDKDLVGATMWVVGFLFEAIGDLQLTLFKRNPANEGKLLTTGLWRFTRHPNYFGNALMFWGYYVIACNARFGWTTIPAPLLMTYLLTSLSGVPMLERSLIRKKPEFVAYAARTSAFIPWFPANIDSASIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1T3</accession>
    <name>A0A0D2X1T3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349253.1">
        <property type="nucleotide sequence ID" value="XM_004349203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1T3"/>
    <dbReference type="STRING" id="595528.A0A0D2X1T3"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1T3"/>
    <dbReference type="OMA" id="KSQLNWG"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1T3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="48298" checksum="7E831F36F9483DB9" modified="2015-04-29" version="1">MTLDIFKVGQQLVLPAAAAAVCLTWSLTAQPHVPPTFASTTVANSDTVIPATPLATLPIAGRAVEFTLPALHLPTAVLAVALYYVFGFCYTAGYHRLWAHQAFVARLPLRLALALGGAANFVGSALTWSRDHRSHHRHIDTKDDPFNIQAGFFHVYPASLFAATSKIGTADVSDLKADWILMLQHGLYMPLAIAVGWILPAWIAGHYWNDAVGGLFYAGVLRAVLFAHIQRFTDALGHTIGTQPYSSRTSARNNAFLSCVTFGENFLNFHYEFPRDYRMGIRAFHIDLTKWVLKALSLVSLVHSLHTTPLKEALLLRVQRKQEKLDAIKAGVKFGPEPEQLPVMTLAEVKAQTGTGRSLVIMDGLVLDMTEFVTEHPGGTAILTPKVGKDITIAFNGGVQRHSKAARNLAALMRVGRLPELEAASVLRTAKSEGESTEHAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2E6</accession>
    <name>A0A0D2X2E6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364240.1">
        <property type="nucleotide sequence ID" value="XM_004364183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2E6"/>
    <dbReference type="InParanoid" id="A0A0D2X2E6"/>
    <dbReference type="OMA" id="WAKLGTH"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="3">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="62601" checksum="D6996FE1D68448A9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2I1</accession>
    <name>A0A0D2X2I1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2I1"/>
    <dbReference type="InParanoid" id="A0A0D2X2I1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="464" mass="50764" checksum="23369BA9CDF3BCFA" modified="2015-04-29" version="1">MEVTRGTVSDAARHDLNEALAYLNGFEIEVSDEIPDPNTTRLFQDYVVQELLKVLRHKTQFLCFGGTIQNNSPAATVGGGTTLIVPGGPGVLGVPNANVHGGYSTIVDLPKMDSALFNREEDVAAALFQQADDQFDRLTTDSTLICLTSAFTAAAVSELFCLHSVYEGEIGWFSGALTIFLATFALLVFYSEMQTAAGATHFYWFGFVGVWSYIRFAEGTWSRMIFAANCQVKRLWLGATFVVMTVFPLAYFAYQDDKYRGMGLAGGLMSAFLVYLLFIFKSGIVERPQGDQDAELNQQTTFLRERLGAYLAQNLREAAEEFPKKVVTLLLVTDIIIFLGSAALVEKVGGKLPNREITVSATAVAWFFTSVQAIVNIHRCNELSAAGTGSTVPAIRPLHGLVAVGISMISLVVVTAVVWSEKLPDNASIWGITFAVNFGFIAIKLYLLHKGNFPMTWFTCCCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2L3</accession>
    <name>A0A0D2X2L3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2L3"/>
    <dbReference type="InParanoid" id="A0A0D2X2L3"/>
    <dbReference type="OrthoDB" id="4238at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF5">
        <property type="entry name" value="DUF4460 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="2">
        <location>
            <begin position="109"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="370" mass="39470" checksum="9FC37289E59648BD" modified="2015-04-29" version="1">MRAAYTQCLATAVQECIATRTRAFSCIGTVALSPSSSSSSSTGSSSGAGARTKRATGAGSAWKNRYAASAAAAAEAAAGNQAQSTASHANANRRPERAGDGTSQAPPRDVQVQFKEFLLKVHPDRFGAVPQVQSLNQASLQEVNAHLQACEDAARVETLPTSVRVAFYVADTTAGSASTETQIAGHREISGLLTKPTADIVMRTSGVPHVQYYGVSAAERGKLRRKVAMQLFLDSMLPAAKSVSGSSRAQQQQQQQQHSTQRKAQSGSHPLKHASTSFSFDPQTNTKTWRGDAATQEDDMYDFAAMIRTQAGGLRAQLASLGSRGPENDAKQATSILNAVKRNSPTTTMDDAMDRTFSRWMERNGSRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X330</accession>
    <name>A0A0D2X330_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348184.1">
        <property type="nucleotide sequence ID" value="XM_004348134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X330"/>
    <dbReference type="FunCoup" id="A0A0D2X330">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X330"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X330"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X330"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="284" mass="31688" checksum="017C4E3A142113C0" modified="2015-04-29" version="1">MLYFIGLGLGDEKDITVRGLEAVRKCKRVFLEMYTSILATPKERLEELYDKKIEVADRETVESNADLILNNAHEDDVAFLVVGDPFGATTHTDMILRAKQRGIPFSVIHNASIMNAIGCCGLQLYNYGQSVSICFFTETWRPDSFYDKIAFNVKGGLHSLCLLDIKVKEPNLDAMMRGKVVYDPPRYMTVNQAVEQLLEVSDKKRDAGETPVYDRKTIAAGLARVGQSDQRIISGTLEELLTADFGAPLHSLVLAGTMHILEIEMLASFAVNPQTFVPLLESHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X357</accession>
    <name>A0A0D2X357_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rcc1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348307.1">
        <property type="nucleotide sequence ID" value="XM_004348257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X357"/>
    <dbReference type="FunCoup" id="A0A0D2X357">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X357"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X357"/>
    <dbReference type="OMA" id="GTECCSI"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X357"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="351"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="481" mass="50669" checksum="EB600B8907C2C587" modified="2015-04-29" version="1">MVELRKRPNEDDVAAAQPSKRVAVDKGNKPTKAAATEKHAAISPAQTAFAAAQKAARDAIAALPAGSVFTVGEGDAGQLGLGEEITSRKKPTPLRSIENVPIVRMAAGGVHTVAITAKGQVYSWGCNDEGALGRSGEEAEPALVKGLIENEFIVAVTCGDSHTNVLSDKGVVYGWGTYRDSAGRMGFDFDTLFKEGGADKATVQFEPKVVLDYTAKHDRVVRISASNNHTIALTEKGNIVTWGCGEHGQLGRVGSRMSDRSKHLHMLGPAPVLIRRKKAAPKDVFTGGFQSFVLFDDDTVVAFGLNNYYQCGIPDVADPIYAPTEVPALSGRQVVSIKGGEHHTLALLADGSVLSFGRGDYGRLGHGNNNELSQPVKIDSLGPSDQVHIDKIATGGIVSYALSNHGEVYAWGMGSNYQLALGPDDDMDTPTLVPAPRFGDNSVLDVVSGGQHTVFLVNYKNKIVAAGASAAPSVSATPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3T3</accession>
    <name>A0A0D2X3T3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346103.1">
        <property type="nucleotide sequence ID" value="XM_004346053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3T3"/>
    <dbReference type="InParanoid" id="A0A0D2X3T3"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3T3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="46907" checksum="3A3E43BD455962ED" modified="2015-04-29" version="1">MFSQARPNASFSTQVKPSSSAAASTLQPMNSSTLKAQGSAFPARSGTNPTSTPASSLMPAASNLDGDGAPALLSVSIHSKPEAQGHQKQLFLWSGVDVTLGQMRGRLRLEALEQERSSVMLETMREERETLLSTLTAKVEKLKRKRQEAIQREQTLRDANDRLRSQANAKQSANDATVKQLQASLHAFKTECASANIQMLTKAHEIDSLMIELDNLREQQARESQASSNEILALREKLEDATQTVKQQAVQLKQALADTEQMRHELAATNTSHATYRTAIASLTEELRVCKAIESHLQEQTHKATNQPGRPPGSAFARPVPRRPHEVEATLSTTSSAEVEQRLRQDLARLRQKLEEQAKALTTALALHAQHTTDCIEHVSEIVLLRAKLDNCLADQASTRAELAACQAQLCVSDATLAPEPEPEPEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A3</accession>
    <name>A0A0D2X4A3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromodomain-helicase-DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345724.2">
        <property type="nucleotide sequence ID" value="XM_004345674.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4A3"/>
    <dbReference type="InParanoid" id="A0A0D2X4A3"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17715">
        <property type="entry name" value="BRCT_polymerase_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03331">
        <property type="entry name" value="Macro_Poa1p-like_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="424"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1312" mass="144420" checksum="6FB60AF6E485C7FA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4S6</accession>
    <name>A0A0D2X4S6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344498.1">
        <property type="nucleotide sequence ID" value="XM_004344448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4S6"/>
    <dbReference type="InParanoid" id="A0A0D2X4S6"/>
    <dbReference type="OrthoDB" id="1933874at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4S6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052674">
        <property type="entry name" value="SelWTH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33638">
        <property type="entry name" value="SELENOPROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33638:SF1">
        <property type="entry name" value="SELENOPROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17388" checksum="7AD999DE5ABFD23A" modified="2015-04-29" version="1">MPGAARRTRATARLDDDDDDDDIVAPSKSIAVKTEKKKDASVDDKKLVQSKIAFQANGAASTDSTATATAPAAGGASAIKQEASVHADKKPRLGLRFQFLTNAFPDAEILINPNKPRRGSFECTMQLGGAESLVWTGVKRGPPRNDKFPDGAKLVADIRQLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X503</accession>
    <name>A0A0D2X503_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343923.2">
        <property type="nucleotide sequence ID" value="XM_004343873.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X503"/>
    <dbReference type="FunCoup" id="A0A0D2X503">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X503"/>
    <dbReference type="eggNOG" id="KOG3433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X503"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X503"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23748" checksum="47CFE09FB412BE38" modified="2015-04-29" version="1">MSGKKKGLSVEEKRKRLLQMFYEKQDFFNLKEVEKYGSKEKGITAMTVKDILQSLVDDSMVDTERIGTSNYYWAFPSKGLQIRKRKIGEMSEELARTKARREELTAAAADAGTGREETEERATAIAEMEEQESILAKVEAELAQYRASDPEVIAARIQETQVCLDAANRWTDNMFSMKSVFRNNFNLEEADFNKAFGVPAELDYVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X552</accession>
    <name>A0A0D2X552_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Brush border myosin I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343522.2">
        <property type="nucleotide sequence ID" value="XM_004343472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X552"/>
    <dbReference type="STRING" id="595528.A0A0D2X552"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X552"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X552"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF713">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="14"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="9">
        <location>
            <begin position="818"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114785" checksum="BEF768FC2D47F9CB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P2</accession>
    <name>A0A0D2X5P2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342764.1">
        <property type="nucleotide sequence ID" value="XM_004342715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5P2"/>
    <dbReference type="eggNOG" id="ENOG502SESW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5P2"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5P2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="180" mass="20186" checksum="19A3C95657E0E15B" modified="2015-04-29" version="1">MEIRGVQSVFATVSPSLHDRQAAVVAPYKGWSVVIAESVKARTGTEPSVTFYKLQTTTPEGRVFTPLRRYSAFDELDRGLRAYYTHALPHLVGNIPEMPPKQWRWFFDHEDPEFINERKVGLQNYLQRLMHLPRIDEFSGYHTFITGERALAPSGSSSSGNANNSSPLSRPASPPPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5R2</accession>
    <name>A0A0D2X5R2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5R2"/>
    <dbReference type="InParanoid" id="A0A0D2X5R2"/>
    <dbReference type="OrthoDB" id="5983338at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5R2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1377"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="2379"/>
            <end position="3022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1329"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1446"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2343"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3421"/>
            <end position="3463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1779"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1449"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3708" mass="397829" checksum="C7ABC8271901046E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9C1L8</accession>
    <name>E9C1L8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002251</name>
        <name evidence="15" type="ORF">CAOG_002297</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349001.1">
        <property type="nucleotide sequence ID" value="XM_004348951.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349047.1">
        <property type="nucleotide sequence ID" value="XM_004348997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9C1L8"/>
    <dbReference type="FunCoup" id="E9C1L8">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="595528.E9C1L8"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9C1L8"/>
    <dbReference type="OMA" id="YWARRTA"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE91111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="151" mass="15969" checksum="1FA19D30C3E11CE1" modified="2011-04-05" version="1">MSGRGKKGAETASSAAANKKQKTRSTRAGLQFPVGRIHRMLRKGSYAERVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRINPRHLQLAIRNDEELNKLLAGVTIAQGGVLPNIHTVLLPKGESEADAAPVKKAASGKKGGSQSQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9CCH8</accession>
    <name>E9CCH8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345408.1">
        <property type="nucleotide sequence ID" value="XM_004345358.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270581.1">
        <property type="nucleotide sequence ID" value="XM_011272279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CCH8"/>
    <dbReference type="STRING" id="595528.E9CCH8"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CCH8"/>
    <dbReference type="OrthoDB" id="8886983at2759"/>
    <dbReference type="PhylomeDB" id="E9CCH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15533">
        <property type="entry name" value="PHD1_PHF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042163">
        <property type="entry name" value="PHF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46309:SF1">
        <property type="entry name" value="PHD FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="523"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1092" mass="114241" checksum="CFD976D2B527F7B2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZK8</accession>
    <name>A0A0D2TZK8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin 1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZK8"/>
    <dbReference type="STRING" id="595528.A0A0D2TZK8"/>
    <dbReference type="eggNOG" id="KOG2284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZK8"/>
    <dbReference type="OMA" id="MYTLFNH"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZK8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="377"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="734" mass="83798" checksum="A873722FAB9FC300" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZV8</accession>
    <name>A0A0D2TZV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZV8"/>
    <dbReference type="InParanoid" id="A0A0D2TZV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="11909" checksum="CE9E3975248473C4" modified="2015-04-29" version="1">MSRAPLDAIQCIVVCEFETARIELEVLPTGLEHFDAGVLAFEKLIETISKRGKRAPDNHLVTRGINPGHQGLQSVGQRWLLASTVRNANDELVLALVRVVHGCMPSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6D4</accession>
    <name>A0A0D2U6D4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6D4"/>
    <dbReference type="STRING" id="595528.A0A0D2U6D4"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6D4"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6D4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1058" mass="113749" checksum="A70F7B3CE041B7E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U930</accession>
    <name>A0A0D2U930_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270227.1">
        <property type="nucleotide sequence ID" value="XM_011271925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U930"/>
    <dbReference type="STRING" id="595528.A0A0D2U930"/>
    <dbReference type="eggNOG" id="ENOG502QTGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U930"/>
    <dbReference type="OMA" id="WAMWISS"/>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U930"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268377" description="PhoD-like phosphatase metallophosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="551" mass="62073" checksum="33EDE8A1AB4CD238" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAC3</accession>
    <name>A0A0D2UAC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAC3"/>
    <dbReference type="FunCoup" id="A0A0D2UAC3">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAC3"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAC3"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAC3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="196"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="688" mass="74393" checksum="289BEE3D4A806CE0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBA3</accession>
    <name>A0A0D2UBA3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WDR13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364153.2">
        <property type="nucleotide sequence ID" value="XM_004364096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBA3"/>
    <dbReference type="STRING" id="595528.A0A0D2UBA3"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBA3"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBA3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="562"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="599" mass="62260" checksum="CAA94615EC04B6E6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGW6</accession>
    <name>A0A0D2UGW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGW6"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGW6"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="12">
        <location>
            <begin position="423"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1327" mass="145362" checksum="43BD702E61F0B789" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH13</accession>
    <name>A0A0D2UH13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Strumpellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346730.1">
        <property type="nucleotide sequence ID" value="XM_004346680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH13"/>
    <dbReference type="STRING" id="595528.A0A0D2UH13"/>
    <dbReference type="eggNOG" id="KOG3666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UH13"/>
    <dbReference type="OMA" id="FFPDNWV"/>
    <dbReference type="OrthoDB" id="565118at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1155" mass="133060" checksum="0734082C530F35D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJV7</accession>
    <name>A0A0D2UJV7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345429.1">
        <property type="nucleotide sequence ID" value="XM_004345379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJV7"/>
    <dbReference type="FunCoup" id="A0A0D2UJV7">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJV7"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJV7"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJV7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="169" mass="19363" checksum="A2291497EE9B5D05" modified="2015-04-29" version="1">MGSSSDTGALLLQRQLQELNRHPIEGFSAGLVDDSDIFKWEVMIIGPPDTLYEGGFFKAHLIFPREYPHRPPKMTFISEIWHPNVHHNGDVCISILHEPGEDKYGYEKASERWLPVHTVETILLSVISILSDPNDESPANIDAAKEWRENRDAFRKKVQRCVRKSQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNC9</accession>
    <name>A0A0D2UNC9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344445.1">
        <property type="nucleotide sequence ID" value="XM_004344395.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNC9"/>
    <dbReference type="InParanoid" id="A0A0D2UNC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="730" mass="76182" checksum="559384FA88FA16FA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP12</accession>
    <name>A0A0D2UP12_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spatacsin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343711.2">
        <property type="nucleotide sequence ID" value="XM_004343661.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP12"/>
    <dbReference type="eggNOG" id="KOG1884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP12"/>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="3261"/>
            <end position="3444"/>
        </location>
    </feature>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="3549"/>
            <end position="3674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1982"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2137"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2224"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2415"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2572"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2869"/>
            <end position="2964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2144"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2239"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2415"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2427"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2572"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2595"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2891"/>
            <end position="2910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2928"/>
            <end position="2949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3738" mass="396462" checksum="58E3D7478178B515" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPT6</accession>
    <name>A0A0D2UPT6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-2-hydroxyglutarate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343373.2">
        <property type="nucleotide sequence ID" value="XM_004343323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPT6"/>
    <dbReference type="FunCoup" id="A0A0D2UPT6">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPT6"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPT6"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPT6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="532" mass="57344" checksum="61513C23DA72134A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQA0</accession>
    <name>A0A0D2UQA0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343500.1">
        <property type="nucleotide sequence ID" value="XM_004343450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQA0"/>
    <dbReference type="STRING" id="595528.A0A0D2UQA0"/>
    <dbReference type="eggNOG" id="KOG2755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQA0"/>
    <dbReference type="OMA" id="MCENLIL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQA0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="335"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="58112" checksum="C98A8A7C7D7637A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URR7</accession>
    <name>A0A0D2URR7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URR7"/>
    <dbReference type="InParanoid" id="A0A0D2URR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="104" mass="11484" checksum="500DD522D62089F5" modified="2015-04-29" version="1">MCMFVRACGCEDGFKAFSIAALSHNISHKIRTRSATRGAGRSRSPCVTLHDHFHCFFFFVDTSRLQESQEQAATHQGEALCECECISCSLSLLQLGLIGLVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US15</accession>
    <name>A0A0D2US15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_007864</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342949.1">
        <property type="nucleotide sequence ID" value="XM_004342899.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US15"/>
    <dbReference type="STRING" id="595528.A0A0D2US15"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2US15"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2US15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14532">
        <property type="entry name" value="PTP-MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="18">
        <location>
            <begin position="167"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="888"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="557"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="12">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="377"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE97761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="948" mass="102938" checksum="E283ABF278173EF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFY4</accession>
    <name>A0A0D2VFY4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365155.1">
        <property type="nucleotide sequence ID" value="XM_004365098.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFY4"/>
    <dbReference type="STRING" id="595528.A0A0D2VFY4"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFY4"/>
    <dbReference type="OMA" id="ETCAYVC"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFY4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="650" mass="71863" checksum="93DA2A5033B60362" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH37</accession>
    <name>A0A0D2VH37_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH37"/>
    <dbReference type="InParanoid" id="A0A0D2VH37"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465">
        <property type="entry name" value="CAVEOLIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266004" evidence="2">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="207" mass="22541" checksum="98CB5167838D0628" modified="2015-04-29" version="1">MPTILAIALALSGACANAAAEHVADATLVPDVEVRGVTLAHGESMLFELSALRSGGSYEVRVSYPAWSPAQFDLQLLTETEARNNELALERRKLLNIEKIVFQHQAEPSEIKSLSPGSFVRVTAWLTGIRSPAAQAQRADIVDSVTFNIVLQSLYLGIPLEAFKVALLALLFAVILIKWVARPLSRMLANFELSARVENEATEQKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIL0</accession>
    <name>A0A0D2VIL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_001248</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349768.1">
        <property type="nucleotide sequence ID" value="XM_004349718.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIL0"/>
    <dbReference type="FunCoup" id="A0A0D2VIL0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIL0"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIL0"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIL0"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="19">
        <location>
            <begin position="53"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="20">
        <location>
            <begin position="502"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="446"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="654" mass="70996" checksum="D5EEC038A28BCBFF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIN0</accession>
    <name>A0A0D2VIN0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349790.1">
        <property type="nucleotide sequence ID" value="XM_004349740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIN0"/>
    <dbReference type="FunCoup" id="A0A0D2VIN0">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIN0"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIN0"/>
    <dbReference type="OMA" id="XIKHESS"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="708"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="928"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="957" mass="103001" checksum="985C7E1FA2F956B2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIU7</accession>
    <name>A0A0D2VIU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349834.2">
        <property type="nucleotide sequence ID" value="XM_004349784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIU7"/>
    <dbReference type="FunCoup" id="A0A0D2VIU7">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIU7"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIU7"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIU7"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="480" mass="53157" checksum="B5BF6B1F184910B7" modified="2015-04-29" version="1">MQALRVVRRLPSSASFASVRRSASAHHSAMSLAPLSSSITSSASRSLSPWHGSETNRAVSSAATSSKSDSNHQEQQGNQRKEGPDYARLLVRGLAIGISGLTAFVAADRVLHPAAPLVVPGPAKSTETSGGKVVVAQEPAARFMAPPLTEDLEHKIAAALRDAAGDPDKLANVDMKLRMEDMVMRAQLAICRAMEDADGQATFKVDRWLRKEGGGGVSCVLTDGAVFEKAGVNVSVVHGILPAAAVREMRSRGKDLPADTSMPFFATGISCVMHPHNPMAPTVHFNYRYFEVTDPRTQQRQGWFGGGCDLTPSYLFEEDAKHFHATYKQVCDKHDPAFYPHFKKWCDDYFNITHRGERRGVGGIFFDDLDDRPRDKLFAFASDCAFAFEEAYLPIIMRRRNLPFTEEQKRWQQLRRGRYVEFNLVHDRGTKFGLATPGARIESILMSLPLTARWEYCHEPAPGSVEEELLAVLRSPKNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKT7</accession>
    <name>A0A0D2VKT7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364806.1">
        <property type="nucleotide sequence ID" value="XM_004364749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKT7"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKT7"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKT7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="71118" checksum="DCB3DAC11187E2D0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKZ5</accession>
    <name>A0A0D2VKZ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348760.1">
        <property type="nucleotide sequence ID" value="XM_004348710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKZ5"/>
    <dbReference type="STRING" id="595528.A0A0D2VKZ5"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKZ5"/>
    <dbReference type="OMA" id="IQISHIN"/>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKZ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="101840" checksum="94734A871FDF2E29" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMT9</accession>
    <name>A0A0D2VMT9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349390.1">
        <property type="nucleotide sequence ID" value="XM_004349340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMT9"/>
    <dbReference type="STRING" id="595528.A0A0D2VMT9"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMT9"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="733" mass="77074" checksum="209373AAB3DA7DAA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPK1</accession>
    <name>A0A0D2VPK1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="12">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003399</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="12"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364238.1">
        <property type="nucleotide sequence ID" value="XM_004364181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPK1"/>
    <dbReference type="FunCoup" id="A0A0D2VPK1">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VPK1"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPK1"/>
    <dbReference type="OMA" id="AFVYFCD"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPK1"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="369" mass="40174" checksum="35F369146FF6FDC2" modified="2015-04-29" version="1">MSKQVLNFAAGPAALPREVLAKAQSELLDYAGSGISVMELSHRSKEFEGLLNRAIADVKTLLNVPDNYKILFLQGGGSTQFAQVALNLLGAKEGNSADYLVTGTWSLKAYEEAKRYGTINLAFPLPANKKYVTVPPQSEWKLNPAASYVYYCANETVDGVEFDFVPETNGVPLVCDMSSNILSRPVDVAKYGLIFAGAQKNVGPSGVTLVIIRSDLLDVKQHPATPIMLGYKLMAENNSLYNTPPTFAIYICGLVFEHLKALGGIAEMNARNDRKSQALYAAIDNSNGFFTSPVVPAYRSRMNVPFRIRGGDDALENKFLKEAEAQNMIQLKGHRSVGGIRASIYNAISEDNVTQLVAFMNKFLAANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ22</accession>
    <name>A0A0D2VQ22_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ22"/>
    <dbReference type="InParanoid" id="A0A0D2VQ22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="116" mass="12801" checksum="CB3080D5E6C60A56" modified="2015-04-29" version="1">MSEAQNAREQPAVELVALQIELGVYDASLEHALGEQTARVVRGRRVACRVQCRPQNGLACRRRDEEVVVGVLQRGRESAALLDHKDAVVEALLADGATEELFIARVEIGVREEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQK6</accession>
    <name>A0A0D2VQK6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQK6"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQK6"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQK6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="11">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="519"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="767" mass="84259" checksum="9E95445761307461" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT44</accession>
    <name>A0A0D2VT44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346717.1">
        <property type="nucleotide sequence ID" value="XM_004346667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT44"/>
    <dbReference type="STRING" id="595528.A0A0D2VT44"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT44"/>
    <dbReference type="OMA" id="MIMEMVL"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT44"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013085154" description="3-methyl-2-oxobutanoate hydroxymethyltransferase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="8">
        <location>
            <begin position="418"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="9">
        <location>
            <begin position="656"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="789" mass="83518" checksum="FC875B56DBB8C2A2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUS4</accession>
    <name>A0A0D2VUS4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346273.1">
        <property type="nucleotide sequence ID" value="XM_004346223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUS4"/>
    <dbReference type="InParanoid" id="A0A0D2VUS4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="219" mass="23293" checksum="0C0149E406FFE23A" modified="2015-04-29" version="1">MLHPPISIWQVSRYGSGSGENSGTARLDRPTLRPPNPEKGELRAPSSLSTPGELVARVASKAWASEPEKCCTPTDGLDRAATGQRLGEQQTSIPLAASIPLTSRLSGQLFRSSDDSHTLPSVRRNVTPRDPSRAPELTSISIAPPVHARLRQTNGARAPASTGLLCLATVTALCDGLTDLHVSHRPHPAAKGGTSMLLALSHDSYKGQTESQMHLRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW79</accession>
    <name>A0A0D2VW79_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW79"/>
    <dbReference type="STRING" id="595528.A0A0D2VW79"/>
    <dbReference type="InParanoid" id="A0A0D2VW79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="753" mass="79059" checksum="43425CAF8FA91FFE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWN0</accession>
    <name>A0A0D2VWN0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-inducible protein DinB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345114.1">
        <property type="nucleotide sequence ID" value="XM_004345064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWN0"/>
    <dbReference type="eggNOG" id="ENOG502S77J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWN0"/>
    <dbReference type="OMA" id="NGWANHR"/>
    <dbReference type="OrthoDB" id="158485at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302:SF1">
        <property type="entry name" value="PROTEIN DINB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="SLR1116 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21307" checksum="E6DB1E61009BACBE" modified="2015-04-29" version="1">MELLHHIQRMARYNQWANAVILDAAATLSETDLKSHASQPFRSIHGTITHILLAQKLWLSRANPEYKCDDIGHFWANGQYAKPEDESSQWEKYETDPAKLGAMLRASDQAIIDFVCSSKLPANPTSAMTYKTTDGAEKSSPYDVSLLHLFNHSTHHRGQITVGLIGRGIPPPEMDMIYWYRSHDQSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYD6</accession>
    <name>A0A0D2VYD6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343731.2">
        <property type="nucleotide sequence ID" value="XM_004343681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYD6"/>
    <dbReference type="STRING" id="595528.A0A0D2VYD6"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYD6"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYD6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="832" mass="88759" checksum="110E7C7CD847B5DE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZK8</accession>
    <name>A0A0D2VZK8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZK8"/>
    <dbReference type="InParanoid" id="A0A0D2VZK8"/>
    <dbReference type="OrthoDB" id="3250442at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZK8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="151" mass="16570" checksum="53CA09474D7F4B40" modified="2015-04-29" version="1">MRVQPKNEPSPATSALNAAPAAASIVPQSSDTLGTEIQQLRSELAAKDQELAAKNHELADERQKLAMKEQELATKNHELGAKEQELAVKDQELAAKEQEIAGKEQELAAAKLELADERQLRAAKEQELQKLLLGIADREDWIDVKSPADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W127</accession>
    <name>A0A0D2W127_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342628.1">
        <property type="nucleotide sequence ID" value="XM_004342579.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W127"/>
    <dbReference type="FunCoup" id="A0A0D2W127">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W127"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W127"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W127"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="36"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="371" mass="40785" checksum="3707A85E9E68A23A" modified="2015-04-29" version="1">MSKRPDFDLRAIVRTNVYSLDPYRCARDDYDQGILLDANENSIGAAVVKKGDDDELTRYPSPYQVEMKRDIAAFRSIQPDQIFLGVGSDEAIDTLVRIFCVPGKDALLITPPTYGMYKVVANMNDVKIQSVPLTPDFQINVEETLKAITPETKIVFLCSPNNPTGNLLATADIIKVLDHPALRGVVVLDEAYVDFTTQGSLAHLLASYPNLVIMQTFSKSFGLAGVRLGMAFASAELTAIMNKFKAPYNINQLTSQVGVQAVSQQGLAQMRSNVAVLLEQRALLEKEFKAMPQVAHVFPSDSNFLLVRFTPSVDAYALYKKMADSGVVVRFRGNEIHCKNCLRVTVGSPSENQELLRQVSALAASPEMAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1S9</accession>
    <name>A0A0D2W1S9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KE346380">
        <property type="protein sequence ID" value="KJE98297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1S9"/>
    <dbReference type="STRING" id="595528.A0A0D2W1S9"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1S9"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1S9"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126161" checksum="E93CB3CC77DE01E4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGY2</accession>
    <name>A0A0D2WGY2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365221.1">
        <property type="nucleotide sequence ID" value="XM_004365164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGY2"/>
    <dbReference type="FunCoup" id="A0A0D2WGY2">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGY2"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGY2"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGY2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="517"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1176"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="352"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="673"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1209"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1253" mass="138447" checksum="9093F26A91FF7217" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH44</accession>
    <name>A0A0D2WH44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein geranylgeranyltransferase type II</fullName>
            <ecNumber evidence="4">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl transferase type II subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Type II protein geranyl-geranyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000441</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH44"/>
    <dbReference type="STRING" id="595528.A0A0D2WH44"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH44"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="208"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="54201" checksum="CDCE33265C373BD1" modified="2015-04-29" version="1">MMHPFTNKKHFEYFDDDSKSNIAAKPKFDTEKTHSLLTLHGPNGASYNFTSCWCSVNRQAMHSDASYESKDATLPSTIHPLLLKKHVEFLVGYTPANNPYEYAVTEHLRMNGMFWSLTALDLMGALDQMDREAIVTFVRDCQHRNPPAPFAELEASEALRSRTVDASHATAAAAASLPSQALPNAPDTNTGVGSDATPSTDARTNAAQEAARQKYVKQLVAASASQRGGFGASIGHDAHVLSTLSAVQILCLFDRLDAIDEEATVAFVASLQQPDGSFVGDVWGEVDTRFSLCAMACLSLLGRLDAIDVQAAVRFIQSTANFDGGFGRVPGSESHASQVYVCLGALTIAGAVDACVDRDQLGWWLAERQLPKSGGLNGRPEKLPDVCYSWWVLSSMCMLDRLQWIDAERLAKFILACQDDVAGGIADRPDDMSDPYHTVFGLAGLSLLARLGAPDAKVQSDQEGVVGVSAGLAIKPVNSVYCLPQDVIDRVMQRNKDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH72</accession>
    <name>A0A0D2WH72_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365355.1">
        <property type="nucleotide sequence ID" value="XM_004365298.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH72"/>
    <dbReference type="FunCoup" id="A0A0D2WH72">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WH72"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH72"/>
    <dbReference type="OMA" id="GCTAKYW"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046349">
        <property type="term" value="P:amino sugar biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="359"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="530"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="682" mass="75432" checksum="E790DD1A4BC56784" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI67</accession>
    <name>A0A0D2WI67_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI67"/>
    <dbReference type="eggNOG" id="KOG4753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI67"/>
    <dbReference type="OrthoDB" id="10048380at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039714">
        <property type="entry name" value="TMEM134"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15016" checksum="932FFF7807C037C0" modified="2015-04-29" version="1" fragment="single">MVRNDYDDYFEDRFAPPASTSALDDFEDDELVNPDVEDDSGLVNATRTYPNAPRQRDYSQLSIWRNPRLRKHWRTVAAALFLVFAGFVLLILGLVAEVSGSLGADGYIFFIIGGVCLLPGAFQCYRLYNAALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIB0</accession>
    <name>A0A0D2WIB0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365165.1">
        <property type="nucleotide sequence ID" value="XM_004365108.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIB0"/>
    <dbReference type="STRING" id="595528.A0A0D2WIB0"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIB0"/>
    <dbReference type="OMA" id="QCVIDDI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIB0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="187" mass="21324" checksum="1CDE25D9C4AD46C5" modified="2015-04-29" version="1">MTEYKLVVVGGGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDDETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVYAITSRPSFEEIHPFREQILRVKDADEVPMILVANKCDLESDRQVSHTEGQATAKQFGIPFMETSAKTRTRVEDAFYTLVREIRRFKKRNASSDTPKKKKAKCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJV5</accession>
    <name>A0A0D2WJV5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJV5"/>
    <dbReference type="STRING" id="595528.A0A0D2WJV5"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJV5"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJV5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="52"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="436" mass="48182" checksum="2EE07806885773E7" modified="2015-04-29" version="1">MVCRVRLFSMAPNFFYFSHFRHTPVVVRDHKFMSWLGGGCALLLQDAAGRKLVVFACLVLLFGLTELTVGILVNSLVLLTDAFHMISDLVSLVVGLVAVRISKKDANNKYTYGWGRAEIVGAFANGCILLAVCVFILLEAIHRFIELETIAQPMYVIIVGCIGFAMNIIGLALFHGHGHGHSHGGHGHGHSHGHSHSHSHGHSHEHKHGHSHEHGHSHSHASKQHGRLNLDESDSDDELVFEDDTPKSLLLHVDDDIHLSEHNKLREFTAGEEDADCDDPEHGSPNKRKRSSNTNLHAIFLHVAGDCLSSVGVIVSGVLEEYLPYDFRFYFDPAISVIISIVIAFSCIPLLRRCLRILLQRAPDHIPCGLIQEQIANIPAVDEVVTLNVWELSDTTVVGTVVVRVNAETSVRTVTESVRSIMTSHGIHHITVEPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKE0</accession>
    <name>A0A0D2WKE0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364835.2">
        <property type="nucleotide sequence ID" value="XM_004364778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKE0"/>
    <dbReference type="InParanoid" id="A0A0D2WKE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029138">
        <property type="entry name" value="SNAPC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15497">
        <property type="entry name" value="SNAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="232" mass="24876" checksum="1889CBDE8577CAD9" modified="2015-04-29" version="1">MALHAAIQRDLDLEEQVLKRLHTKLTDQLHRLQVEETVLERMASEQSSHMSTRSVLDSLLTSAVSTPTHSAFAGSTAASFGGGGYAGSAASTPAFKAPYPSSQHRFSQPSTAASTAPGSPAVYSNSQNGHRPLVPLSLETGPRIRPSGISDISDAASSSLLAADSRDDSMSVDPDADDDDDDDDFDDEDDDLARDALRRILDTELGTNWDEDGDDDGDQGEVFEDEDDEDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW9</accession>
    <name>A0A0D2WKW9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKW9"/>
    <dbReference type="InParanoid" id="A0A0D2WKW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="731" mass="78458" checksum="E701089AC237AE13" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLB1</accession>
    <name>A0A0D2WLB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLB1"/>
    <dbReference type="InParanoid" id="A0A0D2WLB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="117" mass="12941" checksum="2AD98F1D1F9668B0" modified="2015-04-29" version="1">MRISASSWMNGLTSGIGGLASTNWAIASARTASSCPLRSGTWMRSAKRATMVPAIWKAMSRCWMTSQRSGWSNRPRKPRRRILSESRLSSSAAMVLPRLVKSATKVSAFLFFFDVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLC6</accession>
    <name>A0A0D2WLC6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349254.1">
        <property type="nucleotide sequence ID" value="XM_004349204.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLC6"/>
    <dbReference type="InParanoid" id="A0A0D2WLC6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="198" mass="19795" checksum="BE356460804198D8" modified="2015-04-29" version="1">MFKNIIGAIGKKVVESATKSAAGAGAGAGAPEGGVGLAAAKEVKARVVSSGTSGSSGSSSERAAVASSSSSTASSSSDAAGSAQSAWSLAQSLLGTLGGRAGAGAGGGAGIPGMDTSKLLMGLFRLSSETRAELTRHVSDPTVMKLMQEIQPMAKDPAKLVQYISSQPPHVVEKLTKLSTFVAGNKELRDLFESTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLK7</accession>
    <name>A0A0D2WLK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nck1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348786.1">
        <property type="nucleotide sequence ID" value="XM_004348736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLK7"/>
    <dbReference type="STRING" id="595528.A0A0D2WLK7"/>
    <dbReference type="eggNOG" id="KOG4226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLK7"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="208"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="332"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="47710" checksum="E1831E20D5E536B6" modified="2015-04-29" version="1">MAVPIRYATALYDYVAKNSEELTFVKGDRLKLLENDAKLDSKNWWKVEKDNGNSGFVPRNYLQLLKDKNAPKEKKPSVLDRLRSGKKDSMPVIAAAPSHSDQLAVESMKVLCQARVKFQYQATRDDELSLNKGEIVDVLTKEDDGWWQARVHGRVGWFPSNYVAEETPENGPALPNLPPNMAQPAGGLRPNQTLAAGGKQPEFDDVEPALYSATVKFAYKKSATDELDLEPGDIVDILDNADASWFTARSRRTNETGVIPSNYVETIPNSHRGQVPVASAHDVGGAPKFPPANLPPKPMNGGGVGAGGFGSNQQRANNNTNTAGRVVEDQSWFHGPLSRRDTEALMLGRSRHGDFLLRASETKSGDYSVSLRVYDMVKHFRIMFENNRYKIGPREFSNLFELVDHYKEHPIFTTPEGERILLVTPFPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLT5</accession>
    <name>A0A0D2WLT5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348927.1">
        <property type="nucleotide sequence ID" value="XM_004348877.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLT5"/>
    <dbReference type="FunCoup" id="A0A0D2WLT5">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLT5"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLT5"/>
    <dbReference type="OMA" id="FPCHPAP"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000198">
        <property type="entry name" value="CUGBP Elav-like family member 6 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="48599" checksum="59AAAFB5FC9833A1" modified="2015-04-29" version="1">MDPQADIGLGSVINSAALGSAHPALVAAHAVVAQHHPSAASGSGGGEHVKLFVGQVPRTMEEKDLRPVFEEFGPVVELTILKDRFNGLHKGCAFLTYASRESAQLAMAALHGVRVLQGMAHPLQVKPADREEKAEARKLFLGMISRTASEDELRKVFEMYGDIEDIAVLRQPDGTSKGCAFIKYRWREQAVAAISALHGRISMDGCPAPLIVKFADTDRERMQKKAQKHLMHSGHHHMGPYGAMGGMAGMNGFAGAAGNPGFGGHHHHHPHHPHHFGDPSSAATGYNNFFSQHPSQPELAQYSMAQYANAFPGAYGQNVFPGGPNGPAAPNGGLVGAGGLAGLGAGAGVGNAGAAGLAGLPSSGLSKSSAGPEGANLFIYHLPNEFGDVELANAFMTYGTVISAKVYVDKATNQSKCFGFVSFDNPAAAQAAIQSMDGYQIGNKRLKVQLKRSRDPMPNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMX3</accession>
    <name>A0A0D2WMX3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMX3"/>
    <dbReference type="eggNOG" id="KOG1259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMX3"/>
    <dbReference type="OrthoDB" id="6138873at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMX3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057714">
        <property type="entry name" value="PH_NISCH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF35">
        <property type="entry name" value="NISCHARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25625">
        <property type="entry name" value="PH_NISCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1389" mass="151347" checksum="64C72948B2B1446D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN06</accession>
    <name>A0A0D2WN06_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349519.1">
        <property type="nucleotide sequence ID" value="XM_004349469.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN06"/>
    <dbReference type="STRING" id="595528.A0A0D2WN06"/>
    <dbReference type="eggNOG" id="KOG3450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN06"/>
    <dbReference type="OMA" id="IIGDRRN"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="118" mass="12852" checksum="E41F07156E9EA206" modified="2015-04-29" version="1">MADEHDENEAGAAENAQPAQAAHHDAGKADMDKVTDFAEEKEMAQSTDLNQTMKLLTEQHKRDVEERAVRDRALAAVSVKAEDVQLIVTELEVSTQKAEQTLREQNGDLAAALAVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNJ5</accession>
    <name>A0A0D2WNJ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_003619</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNJ5"/>
    <dbReference type="STRING" id="595528.A0A0D2WNJ5"/>
    <dbReference type="eggNOG" id="KOG4286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNJ5"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNJ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="16">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="814"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE92705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="944" mass="102829" checksum="58E34399ABEF7B83" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNM0</accession>
    <name>A0A0D2WNM0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363889.1">
        <property type="nucleotide sequence ID" value="XM_004363832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNM0"/>
    <dbReference type="InParanoid" id="A0A0D2WNM0"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45257" checksum="1B6DDD33B7568F09" modified="2015-04-29" version="1">MVVVPNANCSVPYAGENCDMTFGQVLGGPLIAIQATLGTLFCIELAIGIVLSYRLTVKNGLCLEMNNVMIYVATFLAFWGGIHQIDNRGWHAIYPLWFASLLYDICTSASFTCWLISSNAWAKFVCRAVLQRNSRVAVVVRLAFPVTLAFIWFTQPFATLLMYAIIPFWIGKIVRYMCVCAVFGVWVVGSCYFAWIIRGVLKAAQKRHGDLSSQDEPQRSQHSGSSDHPSTSNHGASSNNKSGGNNNNLAKRRRQLALRRIYRLNGYGIILQLAGLGGVAYNLATYFRERDDLHPPHVLPTPSRGDMVFSFLFDVVHLLVAAMVLWFFRGSRPSANTTKAENPENNGVVWLTESKIVSQFSVPGGNEPDSPDNNLPEVNPLSSASSQGPLDIAVTVDSVPEAAESESPQSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNX4</accession>
    <name>A0A0D2WNX4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEHE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364055.1">
        <property type="nucleotide sequence ID" value="XM_004363998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNX4"/>
    <dbReference type="STRING" id="595528.A0A0D2WNX4"/>
    <dbReference type="InParanoid" id="A0A0D2WNX4"/>
    <dbReference type="OrthoDB" id="6022640at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026180">
        <property type="entry name" value="NSL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443:SF18">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="3">
        <location>
            <begin position="673"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1130" mass="122590" checksum="0A6A42DDD1FF56C1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPH6</accession>
    <name>A0A0D2WPH6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347927.1">
        <property type="nucleotide sequence ID" value="XM_004347877.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPH6"/>
    <dbReference type="InParanoid" id="A0A0D2WPH6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="218" mass="23800" checksum="E550C623D9C185CD" modified="2015-04-29" version="1">MPADTLPEVAPSISPAESAATEKLPASAASDETPAEQSGRVFVEPPEPSTTDGMKAEDLGRDDRTVLILCRLKEGSLAQQLREEHLAAVARSQNSSDGRLPAGERPILPTKGNKMKNLRTVECALNQCWGFAVLPIKPDPKSKDVHKAAAEILDCHVEEVYVQHISQNVFIVCDAGLMPALLPLDLHHQMLQISRSNQQQQQQQQQQQQSAQTAQESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQB5</accession>
    <name>A0A0D2WQB5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED17</name>
        <name evidence="8" type="ORF">CAOG_004561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347308.2">
        <property type="nucleotide sequence ID" value="XM_004347258.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQB5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQB5"/>
    <dbReference type="eggNOG" id="KOG4512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQB5"/>
    <dbReference type="OrthoDB" id="10058398at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQB5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="637" mass="69088" checksum="449F0D4F111F5C71" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQD3</accession>
    <name>A0A0D2WQD3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQD3"/>
    <dbReference type="STRING" id="595528.A0A0D2WQD3"/>
    <dbReference type="InParanoid" id="A0A0D2WQD3"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQD3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12184" checksum="B263A5CCFCEC10A2" modified="2015-04-29" version="1">MSPRARRMTQHNPCQKETEASYKCLDENNYNRDMCGQFFDAYKACKQRWHDERAEARRKKYEEESLFRHIKLAFGFGPQPSSSEQSEAKSEAKAEAMPGSPSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQP7</accession>
    <name>A0A0D2WQP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQP7"/>
    <dbReference type="STRING" id="595528.A0A0D2WQP7"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQP7"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQP7"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000002">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000005">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004126">
        <property type="entry name" value="PRK05614.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="58473" checksum="72D169AEE30DD075" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR04</accession>
    <name>A0A0D2WR04_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR04"/>
    <dbReference type="STRING" id="595528.A0A0D2WR04"/>
    <dbReference type="eggNOG" id="ENOG502QRF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR04"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="45"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1197" mass="122420" checksum="AACE01B0DC30E21C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSB1</accession>
    <name>A0A0D2WSB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSB1"/>
    <dbReference type="FunCoup" id="A0A0D2WSB1">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSB1"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSB1"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25032" checksum="7F8BD037F2ACF3F3" modified="2015-04-29" version="1">MVFGKNTLVAEHSASKFAFYFNAIDALDRVDKTTDSVKVSYAKEWAATRTHSAGINDVIKPFDWTFSSDYTGTLINPDTVTITEIDEEIDMEKLMQRDAILHYSDVLLYEDELADNGCSIMNVKIRVMPGSFFILLRFFLRVDGVFVRVNDTRIFHEFSTNYILREFTSREQKFSVLNERCAPGTIHDLEFYSKPQTLHRLLDMTAGKREKIAFNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSQ9</accession>
    <name>A0A0D2WSQ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamic acid decarboxylase isoform 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346846.1">
        <property type="nucleotide sequence ID" value="XM_004346796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSQ9"/>
    <dbReference type="STRING" id="595528.A0A0D2WSQ9"/>
    <dbReference type="eggNOG" id="KOG0629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSQ9"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="59603" checksum="02C6E2FAB5CE75E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTK9</accession>
    <name>A0A0D2WTK9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTK9"/>
    <dbReference type="InParanoid" id="A0A0D2WTK9"/>
    <dbReference type="OrthoDB" id="5963585at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTK9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029715">
        <property type="entry name" value="FAM35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14495">
        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14495:SF2">
        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="2">
        <location>
            <begin position="416"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="923" mass="99861" checksum="2EC90121009717E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTT6</accession>
    <name>A0A0D2WTT6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346278.2">
        <property type="nucleotide sequence ID" value="XM_004346228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTT6"/>
    <dbReference type="FunCoup" id="A0A0D2WTT6">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTT6"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTT6"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTT6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="51"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="754"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="908" mass="101645" checksum="9E2F516F807D7B64" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU15</accession>
    <name>A0A0D2WU15_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU15"/>
    <dbReference type="STRING" id="595528.A0A0D2WU15"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU15"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase ATP-dependent N-terminal" evidence="12">
        <location>
            <begin position="343"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="11">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="639" mass="67620" checksum="6D72652A6325E180" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU31</accession>
    <name>A0A0D2WU31_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346452.1">
        <property type="nucleotide sequence ID" value="XM_004346402.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU31"/>
    <dbReference type="STRING" id="595528.A0A0D2WU31"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU31"/>
    <dbReference type="OrthoDB" id="72369at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU31"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266583" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="76782" checksum="7C0A6557E288D91E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU71</accession>
    <name>A0A0D2WU71_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345457.1">
        <property type="nucleotide sequence ID" value="XM_004345407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU71"/>
    <dbReference type="FunCoup" id="A0A0D2WU71">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU71"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU71"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU71"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017222">
        <property type="entry name" value="DUF34/NIF3_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037490">
        <property type="entry name" value="UCP037490_NIF3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="374" mass="39673" checksum="07B6CF8AD9C3689D" modified="2015-04-29" version="1">MELSKVLQTLKTFAPLRLAESWDNVGLLVEPVTKRRPIDKILLTIDLTERVVDEAAQHSIPLIIAYHPPIFAALKKLTAGATKERIAVKAIEHGIAIYSPHTSYDSVQGGINDWLASGLGEASAISVLQPHTFHHDGDSQTSSGTHRASVYGLAGQLAELRTAIASILGSESSFATFSSNDSASRSKLEFKCQQSHLGSLAALLAKHAGNGVTWETHSLEKLPQPGTGQGRLVTLAQPTPLPQLLTKIKAHLQVEHVRIALPSAAVPAAQVPPKTQAAALEHAKNVLVQKIALCAGSGSSVMRGVRADVYLTGEMGHHDVLDAVSSGAAVVLCEHTNTERGYLAKLRESLAELFGTAGVQVTVSQQDADPLVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUC8</accession>
    <name>A0A0D2WUC8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344225.1">
        <property type="nucleotide sequence ID" value="XM_004344175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUC8"/>
    <dbReference type="InParanoid" id="A0A0D2WUC8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="25456" checksum="12EF3B7310D05317" modified="2015-04-29" version="1">MMIGGAPKRGRPSHASLVAQAAIQASNAAHQQQQNSARLSTLIHEQAERARANMHEYQQQQLASRSHAASLFGSLHGPASSSSSSNINNSTSSGLQADGSLSAVAPDGTRLVRTWVKKWVDVAHFRTYKWVPELHPDRRDRKRAIPAVARPVTKMARQEEPNDADDNQETDSGAPILDEAQAIASQASEARQTQQSIATSIAQEAAGIIHARGLKRELNDEDSSDAESDPKDESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUE2</accession>
    <name>A0A0D2WUE2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345573.1">
        <property type="nucleotide sequence ID" value="XM_004345523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUE2"/>
    <dbReference type="STRING" id="595528.A0A0D2WUE2"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUE2"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000019">
        <property type="entry name" value="Myc proto-oncogene protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002418">
        <property type="entry name" value="Tscrpt_reg_Myc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00044">
        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="147" mass="16414" checksum="8ACDAFC3C2324DE8" modified="2015-04-29" version="1">MSDSEDADTSSGEDVPQQDTSNMTPAAAAAIAALASASAKRSSGKIEKASKKKKPPRDADKRHSHNLLERKRRDHIKERFTSLKDVVPTLDEEQNPSRSAILHEATVYINKMREATFSEEHQVRHLQTANQSLAKEVQQLEAEINKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUG1</accession>
    <name>A0A0D2WUG1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345601.1">
        <property type="nucleotide sequence ID" value="XM_004345551.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUG1"/>
    <dbReference type="InParanoid" id="A0A0D2WUG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054235">
        <property type="entry name" value="DUF6962"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22285">
        <property type="entry name" value="DUF6962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255258" evidence="2">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="199" mass="20965" checksum="04BF3B5A7D98C820" modified="2015-04-29" version="1">MRFNKSVLFELVLVAACVHAVHSVNKHTHADGRERVMWTVGIGSIGVAAFLGAIVYSGETSFSDLHKVATRAGGTIGVAGLLLGSLITLDVLRPYGKETELMVLGAGLVAGVAVFITSESNERARKSFQVAVMASIIVVSLLKIGSSSAAIYLLASVLTLAAVDPLKKPLRDALNISDVDVYHIMLTLSVYLFGLAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUK8</accession>
    <name>A0A0D2WUK8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUK8"/>
    <dbReference type="InParanoid" id="A0A0D2WUK8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="131" mass="14788" checksum="194DABF23DE32F1C" modified="2015-04-29" version="1" fragment="single">MISAIFEFVLYLFVLYIFGFPIFCLSRFNGCVRLRCCSPSGPSAPVALINLIKCVLLLFFFSCSVSSVGEGRGSRKARLLWVGCEWLSSKPQNALKLDVGARVSPRPLRMIACMWEQPCFSRGFWHLLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVL5</accession>
    <name>A0A0D2WVL5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343874.1">
        <property type="nucleotide sequence ID" value="XM_004343824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVL5"/>
    <dbReference type="STRING" id="595528.A0A0D2WVL5"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVL5"/>
    <dbReference type="OMA" id="SHMENIP"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVL5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006:SF606">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27006">
        <property type="entry name" value="PROMASTIGOTE SURFACE ANTIGEN PROTEIN PSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="424" mass="47417" checksum="6B436233713DDE0A" modified="2015-04-29" version="1">MRSSLPQDQELAAQDEELAAKDQELAAKDQQLRSKLAAKDQKFNSRLAARDQQSRSELAAKDKELQQLRSNLAVKDKELATKRQELKKLRSDLAAKEQSLATKEQNLAAKDRELKSALDRIDVFERNQPAVGSFSSFDGPIPQVPLATLVVATSNFAADSLLGKGAFGCVYGTRLPGPRVAIKRLSTDSKQGAAEFKAELDSLSKFRHANIIAILSYAEEGDERCLVYEFMPNGSVRDRLDRKNHTPPLIWSQRHRIAADVSRGMHYVQTAFPDHTLFHLDLKTDNVLLDAYFNAKVSDFGLVRIATHLDEQSYQRTQHVQGTKVYMCPEFFAEGKMTIKTDVHSFGMILLELVTAAKPGPRLKAETRKAVKTQKINEMLDSALRPTRADRNRIKKTVTLALECLDDIADDRPSFGQLIATLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVT3</accession>
    <name>A0A0D2WVT3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="12">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006741</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROX family. NO66 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="12"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVT3"/>
    <dbReference type="eggNOG" id="KOG3706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVT3"/>
    <dbReference type="OrthoDB" id="425950at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032453">
        <property type="term" value="F:histone H3K4 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049043">
        <property type="entry name" value="WHD_RIOX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21233">
        <property type="entry name" value="WHD_RIOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="253"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="61905" checksum="88092E010774B352" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVX4</accession>
    <name>A0A0D2WVX4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343400.1">
        <property type="nucleotide sequence ID" value="XM_004343350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVX4"/>
    <dbReference type="FunCoup" id="A0A0D2WVX4">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVX4"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVX4"/>
    <dbReference type="OMA" id="DCTSHDD"/>
    <dbReference type="OrthoDB" id="1100342at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVX4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="336" mass="36064" checksum="9C5746224969D595" modified="2015-04-29" version="1">MSNETDECLFEAVDDYDQRYNIAAFFIILVTSMMGTLLPILAKRNPTWICFRSPFVFTIGKHVGTGVIIALALIHLLSPAYEELGNPCLPAAFAEDYTFAPLFAMLGALVMHVFETLAAMHAPKAELKSETSQSPSMAQFTSSDCCDPESGQSTTPTTDSLAFAHGHSHGALLGITSAERTIAAYVLEFGLTAHSVIIGLTVGVSSVTDLETLIPALVFHQFFEGIALGARLVECNFSKLNEFLLAFIYSVSAPVGIAIGIGIVNSYNENGVTTNLVQGTFDAVSAGILLYVGFSQMLAIEFPRDFAAASSRARRVALFVAMWVGAGIMAFIGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWL3</accession>
    <name>A0A0D2WWL3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343902.2">
        <property type="nucleotide sequence ID" value="XM_004343852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWL3"/>
    <dbReference type="STRING" id="595528.A0A0D2WWL3"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWL3"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWL3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="30"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="342" mass="35415" checksum="63B66869193A5252" modified="2015-04-29" version="1">MQTSAALPLHIETACIHSIPLSRLLPAEVQGQQRPVYLKLENTQPSNSFKLRAIGNLCAKAVARGGCVRFVSSSGGNAGYAAAVAARMLGLPVHVVLPTSTPGFMRELIESEGAIVTVYGSAWDEAHAHALELAAEPGSVYIPPFDHPDLWEGTSTLVDELFRQLPEKPAVIAVAVGGGGLLAGVVEGLHRVGNAAWKDVPVIAVETAGADSLAKSVEAGELVTLPAITSIAKSLGAKRVAERAFQLAREHPVICQVVPDASATRAVVQFAEHHHMVVEPACGAALAALYDSLLASDSVQKAISNVSGISASAPIVVVVCGGNVVTLDMLASWRTAACSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXU3</accession>
    <name>A0A0D2WXU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXU3"/>
    <dbReference type="FunCoup" id="A0A0D2WXU3">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXU3"/>
    <dbReference type="InParanoid" id="A0A0D2WXU3"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF25">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="25516" checksum="EF6EC8796719241A" modified="2015-04-29" version="1">MFSVRRGKALFSCNPQPSGSGFDSLMLRASRLLTFGVAGVLGPLGRHPVAVAFHLLFRTGAVLAYLLCGFFSDNFVTNFIVIVMLLSLDFWTVKNVSGRILVGLRWWNEVKPDGQTMWRFESRKDTSGIDANESRLFWITLYLYTAVWLLFSILNLALKFQWLLVAFVGLALNLANVIGYTKCDKNAKQKLANLAGSFVTPSMVTSAAKTLISMATSSSSNNNQTRQPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXY7</accession>
    <name>A0A0D2WXY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342880.1">
        <property type="nucleotide sequence ID" value="XM_004342831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXY7"/>
    <dbReference type="SMR" id="A0A0D2WXY7"/>
    <dbReference type="FunCoup" id="A0A0D2WXY7">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXY7"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXY7"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="464" mass="50660" checksum="BDB002BEB4D75FCF" modified="2015-04-29" version="1">MGKEKTHINIVVIGHVDSGKSTSTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKFYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVGINKMDSIKFAEERYNEIVTEVSNYIKKIGYDPKTVAFVPISGWHGDNMLEASENMPWFKGWTIERKEGNASGKTLIEALDAISPPKRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPSNVTTEVKSVEMHHESLPEANPGDNVGFNVKNVAVKDIRRGNVAGDSKNDPPKETKTFTAQVIVLNHPGQISNGYAPVLDCHTAHIACKFQDIKEKCDRRSGKKLEDAPKFVKSGDAAIVELLPTKPMCVEAFSDYPPLGRFAVRDMRQTVAVGVIKAVDKSAKDAKADGKDKKAAAPAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY35</accession>
    <name>A0A0D2WY35_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342956.1">
        <property type="nucleotide sequence ID" value="XM_004342906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY35"/>
    <dbReference type="STRING" id="595528.A0A0D2WY35"/>
    <dbReference type="eggNOG" id="KOG1340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY35"/>
    <dbReference type="OMA" id="ECHLCEM"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY35"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255348" description="Saposin B-type domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="21006" checksum="C60A0CB4CD41E6D1" modified="2015-04-29" version="1">MNKAFVAILLLGFAAFAAAAPAPKAGGSAECVLCEFVMTKVEAKLQANATAAQIEQLLDGICADIPSTLRSECNSFINTYTPTLIALLVQKLPPAQICSTLGLCSSVAKVEASVACTICEFAIRELDQKIVANGTVSEIEAEVEKVCTKLPSTIRNECDSLITLYTPEIVNAIASDIDPAVVCSLIHLCTAEKVIAVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYA8</accession>
    <name>A0A0D2WYA8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346415">
        <property type="protein sequence ID" value="KJE98405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYA8"/>
    <dbReference type="InParanoid" id="A0A0D2WYA8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="192" mass="21993" checksum="8EB745DB785EBB1F" modified="2015-04-29" version="1">MARPWTRQGEAHQRNRAQMLNTRNKTTRRNLSSVIVEHPQACPGPGTRQCPCYARMMSRRLDVMHLRPQDANIEPEKPAQSSTQPTKRRSAHSDLNPNSRSLKQTIDQICKTIDRVLNGELANWLENTGKRETILKFGWLIADDELFGYYDYFLSFVELGAAWETQNIVDSLHHSNISEAIATLEAWCVPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYF7</accession>
    <name>A0A0D2WYF7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H+ transporting ATP synthase O subunit isoform 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342624.1">
        <property type="nucleotide sequence ID" value="XM_004342575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYF7"/>
    <dbReference type="FunCoup" id="A0A0D2WYF7">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYF7"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYF7"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYF7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="196" mass="21527" checksum="9F8CDD027EF6E82B" modified="2015-04-29" version="1">MSSTKATGLVKPPVRVFGVAGRYAEALYSAASKNNALEAVEKDLAQVRNLANADAAFNEFLNTPLLKRSDKKKLAIDITKKIKLNALSQNLLGALAENNRLDYTLQVADAYDTIMRAQRGIVSCNVASANPLDQSFQNQLQQALKGFVKPNEKITFNFRVEPTIIGGLVIELGDKYIDMSVLSRIQKLSQTLREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYQ1</accession>
    <name>A0A0D2WYQ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342748.2">
        <property type="nucleotide sequence ID" value="XM_004342699.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYQ1"/>
    <dbReference type="STRING" id="595528.A0A0D2WYQ1"/>
    <dbReference type="eggNOG" id="KOG2492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYQ1"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYQ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="199"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="343"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="632"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="748" mass="80845" checksum="6D5652998A0A502D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X055</accession>
    <name>A0A0D2X055_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X055"/>
    <dbReference type="STRING" id="595528.A0A0D2X055"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X055"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X055"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="222"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="787" mass="87180" checksum="728A77A1090C29A4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0E1</accession>
    <name>A0A0D2X0E1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009311</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0E1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0E1"/>
    <dbReference type="eggNOG" id="ENOG502QTBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0E1"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0E1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038060">
        <property type="entry name" value="C12orf66-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018544">
        <property type="entry name" value="KICS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09404">
        <property type="entry name" value="C12orf66_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160651">
        <property type="entry name" value="FLJ32549 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158548">
        <property type="entry name" value="FLJ32549 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115133" checksum="D51DE96BE3C85867" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F5</accession>
    <name>A0A0D2X0F5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000534</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365405.1">
        <property type="nucleotide sequence ID" value="XM_004365348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0F5"/>
    <dbReference type="eggNOG" id="KOG4278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0F5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="136"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="232"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="366"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="622" mass="68154" checksum="D35CBE5023E97E34" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0L4</accession>
    <name>A0A0D2X0L4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365646.2">
        <property type="nucleotide sequence ID" value="XM_004365589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0L4"/>
    <dbReference type="InParanoid" id="A0A0D2X0L4"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0L4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="388" mass="41339" checksum="6BA1C5022ED25411" modified="2015-04-29" version="1">MQSTAAELLLRSSRVAATAVSASPRSVRSSSITPRSSARVGPAAVARAFTSTPCSHPRLSLSPSAALAARLPSPQLRAQSYSSSSSPAPAQAPPSSAEANNKVTTTTTATAAATNGNALATVDAATNADEQATKNPKDASTQADAPTTKKPNFFKRFQIGLLDLTRKTPALPPSASMLKPFEASTTLSHSKYAVKFPSRVLTAINGQTVDLSEAFTRGISIVSVAFDQFGALRNASFTHEFRSQYGSNPYVNDFEILMNRMPMMRVLQPMFNRNLLAAIPQQRHGSVFNLPAVDEELAAELGIRFYTGNFIYLVDEQGLIRWQAVGKALPREVTAMIHCANTLLSTRGQHHSVTRTNGTRMLSTPSDVVAAVSAQLPPLPSAPSSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1B3</accession>
    <name>A0A0D2X1B3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364687.1">
        <property type="nucleotide sequence ID" value="XM_004364630.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1B3"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1B3"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1B3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47917" checksum="46850E7F6D156479" modified="2015-04-29" version="1">MPKALLYKNMTPRQRELYDKVMNAPNERLFLYDNQVGVDGALAIAEAIKVNTSLTELSLVKIDLGDAGARAIAEAIRVNRTLTELNLSRNQIGPVGAQSLAAALKVNKKVEVLFLAANQFGDAGLQEIAEMLFVNKTLEMIYLHENQIGDAGAPAVAEALEVNKTLKELKLSENHIGDAGAQAFGEALKVNSTVTIDLSNNCIGKAGARAMADARKVNPTRLTPHMGSQINPLAFALLPRLASADDIQAVFHLLTSRHEVEATAYSAPRRGSTGRGKPRKLSAPKGPTTPPEPAVLPALPAEIAECIMHEAYYWPAVQHTKRMQFNEDGPADVLQVTVPGDSVGDSARRVKAIQVLRGWRHPPADTSPLVFDLVVRDERGAVRYEGAAKPEFLDSTVQRVTIVPATHPIMRQMRDGWKVQVRRSKAVIGVVFEHLYLGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1B5</accession>
    <name>A0A0D2X1B5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit beta</fullName>
            <ecNumber evidence="12">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="12"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364696.1">
        <property type="nucleotide sequence ID" value="XM_004364639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1B5"/>
    <dbReference type="FunCoup" id="A0A0D2X1B5">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1B5"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1B5"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1B5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="544" mass="57744" checksum="DC09B838C4617447" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1C1</accession>
    <name>A0A0D2X1C1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CCR4-Not complex component Not1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364719.1">
        <property type="nucleotide sequence ID" value="XM_004364662.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X1C1">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1C1"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1C1"/>
    <dbReference type="OMA" id="MARTHTT"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1C1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="550"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="757"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1646"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1928"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="2490"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2318"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1575"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2118"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2318"/>
            <end position="2330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2874" mass="311500" checksum="5F0FC06EBCF87846" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1L2</accession>
    <name>A0A0D2X1L2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002213</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1L2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1L2"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1L2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="337"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="179"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="609" mass="66438" checksum="6780F5B54520811D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1V4</accession>
    <name>A0A0D2X1V4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripeptidyl-peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349344.1">
        <property type="nucleotide sequence ID" value="XM_004349294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1V4"/>
    <dbReference type="STRING" id="595528.A0A0D2X1V4"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1V4"/>
    <dbReference type="OMA" id="VTITPDC"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1V4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="257"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="612" mass="65120" checksum="AC04D8788513175C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y5</accession>
    <name>A0A0D2X1Y5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349483.1">
        <property type="nucleotide sequence ID" value="XM_004349433.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y5"/>
    <dbReference type="FunCoup" id="A0A0D2X1Y5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Y5"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Y5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF60">
        <property type="entry name" value="COUNTIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254975" description="MD-2-related lipid-recognition domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="4">
        <location>
            <begin position="45"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="17029" checksum="FCE45FB3187E2116" modified="2015-04-29" version="1">MNTKIAVLALLAVLAVAASAAPVSQTKYLEYFEDWDAPNRLGASWTSCGGANDKFKISSVVVTPEPIVKGGDLKVTFNGVLASNVTAGEMNLSMKWGFLTVLTQTVDVCTVDPTAPCPLAAGQLSISSVSAIPASTPSGTYTATIKVTDQTKTQISCVTLNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2J6</accession>
    <name>A0A0D2X2J6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363321.1">
        <property type="nucleotide sequence ID" value="XM_004363264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2J6"/>
    <dbReference type="FunCoup" id="A0A0D2X2J6">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2J6"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2J6"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2J6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="242"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="433"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="707" mass="77560" checksum="B0479DE0CC6010FB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2L0</accession>
    <name>A0A0D2X2L0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZC3H3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2L0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2L0"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2L0"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2L0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="751" mass="80459" checksum="2C49ADB52F1C723B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X310</accession>
    <name>A0A0D2X310_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348104.2">
        <property type="nucleotide sequence ID" value="XM_004348054.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X310"/>
    <dbReference type="STRING" id="595528.A0A0D2X310"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X310"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47365" checksum="6D1D89FB4EE40B0E" modified="2015-04-29" version="1">MVIAVVSSAVCNVVSVAYPAYASFKAIKTRNIVEYQQWMMYWIVFGFFSVAALVLDALLGSWFPLYNEIKMLFVLWLMLPQTKGAVNIYKHFLHLKLVENEQIIDATGNAAYMAVRHMSLESAKRFCILVQQAFVQALANGQHVFFQQLNHAQMLQQHQQHQQLQHPQGQLQGPEASARQRPMSLVLEELPDDYDVSQPLSVRSIRPEPSHPANFFSENDAAAFFGQMDVSNASSNASTPRGPPLSGSSTSSEPWEFVDESVRFRAQQQQQQQQHPQPPQSAHPTSHLTTAAAALRQRFGRTPPNKRAATAPSDQLAAARADASPVSFGEVTPPARSRPVSQYGDATSVYETSPITPPSRPAPRPVGDNDHVDRLTEHENNLRRLRQHADQLAANQAEALRQLQASSSSSSSSAPAPAEPHKSSWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X385</accession>
    <name>A0A0D2X385_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X385"/>
    <dbReference type="FunCoup" id="A0A0D2X385">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X385"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X385"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X385"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="58"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="271" mass="29996" checksum="48D32AEC9402F091" modified="2015-04-29" version="1">MSLSSPSSATGLSHAAALLPIPASPLAAATAAAAAAASTAALPPPPPQAGSPALSNKRRQGLSLSCPIVYGNLAEVPDESHTHRWTVYVRGADGDDISYVVKKVVFKLHDSYAESLRTVEQPPYEVSETGWGEFEVQIKVFFRDAVEKPVTIFHHLALYPHAATLQPSKKLLVFEQYDEIVFNDPSDKLYQMLMRKERIPGFKKTAPFRDYSEFEVAQLEQLKESKDQVRAEMAKQKAKYRDLDEEAQVLKREIAALEQELNIDATAMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C7</accession>
    <name>A0A0D2X3C7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C7"/>
    <dbReference type="InParanoid" id="A0A0D2X3C7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="191" mass="21254" checksum="863DFCEED1CCAE8F" modified="2015-04-29" version="1">MGARRSSRTRLAVVEQELLVDSRPQPPAIVVPNQARVEEWLSTHQGVHMHPLRHWLGRIRRIHSCRMPGGIQLQVGTVQTNFLDGAGFGHKVLVGQIGGRRPLHGHVRNGKRVRQVKVLVQHNVRVGPRSAIVSAGGHANVAMPGLGVLGLKEHVPVVRSLRVVEQERICDERHQLVRDQRAVDGGQRRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4I6</accession>
    <name>A0A0D2X4I6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345241.1">
        <property type="nucleotide sequence ID" value="XM_004345191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4I6"/>
    <dbReference type="InParanoid" id="A0A0D2X4I6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="11644" checksum="6CA8A162401EE7AC" modified="2015-04-29" version="1">MDQCQCVCDQVKQRLMRMIQQQAQDQCTDTECLRGVEHPAGLAGGFDPMLIAALVWLAVAAVLFAMRPARSATAAHAAANAADAAPTKPGRSGDRDDHPRQPPPPPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4M5</accession>
    <name>A0A0D2X4M5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344282.2">
        <property type="nucleotide sequence ID" value="XM_004344232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4M5"/>
    <dbReference type="STRING" id="595528.A0A0D2X4M5"/>
    <dbReference type="InParanoid" id="A0A0D2X4M5"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4M5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056691">
        <property type="entry name" value="DUF7789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25044">
        <property type="entry name" value="DUF7789"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="3">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="3">
        <location>
            <begin position="187"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="39481" checksum="59EC17E9050F3C8E" modified="2015-04-29" version="1">MSQPQSARGRVDVSDLLAPSHHGTSANSDVVDTWAGKVTRLKALHPWAKAFLVVAMLEILIVVALTIQRMAIISYPFTDDSRADMTYAVVLLINAVFSCYYAVHGCLRERKTEVAAFVVASLTVTIYVVYQYAFNPPNTDPDYESNWHISREIRFILICIFEPMALALAFLTQRHFGWVEYKTVGANVDYMRLHRDYSMYVTFLKFDMQIQLSLVVLSLFSRLELDAEMGIDMAAVVVVLITMIVGWLAVQSENRSAMIFVAISSVITLAYDVYTIYKFSSSSNDASSFARYAILAAASFAILIRLVLFFFIRRVVSNFGQGLKSMLHKRSHHQRPASEEDPLIRPSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X578</accession>
    <name>A0A0D2X578_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZWILCH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X578"/>
    <dbReference type="STRING" id="595528.A0A0D2X578"/>
    <dbReference type="eggNOG" id="KOG4803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X578"/>
    <dbReference type="OrthoDB" id="5556307at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X578"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="766" mass="79962" checksum="3B195CE132E4382A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I8</accession>
    <name>A0A0D2X5I8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343051.2">
        <property type="nucleotide sequence ID" value="XM_004343001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I8"/>
    <dbReference type="eggNOG" id="KOG4167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5I8"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="466"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111462" checksum="715659F8BB7234A6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5L1</accession>
    <name>A0A0D2X5L1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342659.1">
        <property type="nucleotide sequence ID" value="XM_004342610.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5L1"/>
    <dbReference type="InParanoid" id="A0A0D2X5L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="55" mass="6134" checksum="4C463EDD9187535E" modified="2015-04-29" version="1">MNFLKRAIVEQPVISLSVLFGTLGPLMVLISSPDSSRHIKPFLEPPFVTLPEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P9</accession>
    <name>A0A0D2X5P9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270889.1">
        <property type="nucleotide sequence ID" value="XM_011272587.1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5P9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2145" mass="227938" checksum="9B8856C799586B1D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9C1L6</accession>
    <name>E9C1L6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348999.1">
        <property type="nucleotide sequence ID" value="XM_004348949.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270156.1">
        <property type="nucleotide sequence ID" value="XM_011271854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9C1L6"/>
    <dbReference type="STRING" id="595528.E9C1L6"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9C1L6"/>
    <dbReference type="OMA" id="MPLREFK"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="E9C1L6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="184" mass="20488" checksum="008730D170AD4263" modified="2011-04-05" version="1">MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGAQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLTDLREQILRVKDTDVVPMVLVGNKCDLEDERMVGKEQGQGLAKGWSCAFLESSAKAKIMVNETFYDLVRQINRQHPNSGKADKKKGGCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9C618</accession>
    <name>E9C618_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363477.1">
        <property type="nucleotide sequence ID" value="XM_004363420.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270318.1">
        <property type="nucleotide sequence ID" value="XM_011272016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9C618"/>
    <dbReference type="STRING" id="595528.E9C618"/>
    <dbReference type="eggNOG" id="KOG3522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9C618"/>
    <dbReference type="OMA" id="HTINSIP"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="PhylomeDB" id="E9C618"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="558"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="939"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1079" mass="115895" checksum="78BD8FEE7E16B00B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0R1</accession>
    <name>A0A0D2U0R1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme E2 W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365282.1">
        <property type="nucleotide sequence ID" value="XM_004365225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0R1"/>
    <dbReference type="STRING" id="595528.A0A0D2U0R1"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0R1"/>
    <dbReference type="OMA" id="WQMDIKV"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0R1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="150" mass="17058" checksum="9349A3A2AC7B3728" modified="2015-04-29" version="1">MAGRFTRRLQKELLDLQRSPPTGVKLEDNTTRLDQWRIHLTGADGSLYAGEHFVLRFRFGNNYPMEAPEVVFEGPNIPMHGHIYSNGHICLNVLYNEWSPALSVQSICLSLLSMLSSSPEKSWPPDNDTYVRRAIASPKQTSWAFHDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3J3</accession>
    <name>A0A0D2U3J3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 31 TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349717.1">
        <property type="nucleotide sequence ID" value="XM_004349667.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3J3"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3J3"/>
    <dbReference type="OMA" id="VHIHYEL"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3J3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06597">
        <property type="entry name" value="GH31_transferase_CtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252304" description="Glycoside hydrolase family 31 TIM barrel domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="75"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="636" mass="70551" checksum="B24636B03DF0E19F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6B2</accession>
    <name>A0A0D2U6B2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bridge-like lipid transfer protein family member 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364810.1">
        <property type="nucleotide sequence ID" value="XM_004364753.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6B2"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6B2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1885"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1999"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2328"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1656"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1676"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1705"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1890"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2543" mass="274863" checksum="6CADDBB2DF433FF4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6G3</accession>
    <name>A0A0D2U6G3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6G3"/>
    <dbReference type="STRING" id="595528.A0A0D2U6G3"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6G3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6G3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF86">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="263"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="532" mass="58619" checksum="AFF0E4C041EC3E6A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6P2</accession>
    <name>A0A0D2U6P2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6P2"/>
    <dbReference type="InParanoid" id="A0A0D2U6P2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265439" description="DUF4397 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47718" checksum="F53957BE27A1DAA5" modified="2015-04-29" version="1">MRSWRLLVVALTVAATVTTVVQHCDAAAGIRFAHFGMDDANTPLPKLSLRSANLDEFIAYNISFGTAYPSTGYNELPVGVHDMRLMIWNQASGQDIEIGSTSITVQDQNSYTIFCTGIYKFLMALPDASPSLTEITHTAFLSADAVNAQLLLNGAIPYVPSTAHMYMSFGYYPAVSGQSKWMYMSYWTDYPSGDYNTVPAWNASAIHVVGPLTPAVSGDPNSPDKSFVTTAPLASIAQPSNSTASECVRSSQCGYAYLPDSRLATQSLDSEQYYAEVLSFSNVDVTRDNVAIRGFVTKSQCIQLIPDHRTLTSGGRAVIRFAHLATDLGPLSVYLNSASGTPLIARVDRFQVYESSAIVGTYSVVVTRFGSLQPLNVTGRIEHSFFFGANGEYTISLFRPNQHSLDSRILTGVQGTNGAATASVSVYLLAASFVLAILPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U706</accession>
    <name>A0A0D2U706_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348916.1">
        <property type="nucleotide sequence ID" value="XM_004348866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U706"/>
    <dbReference type="FunCoup" id="A0A0D2U706">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U706"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U706"/>
    <dbReference type="OMA" id="PIYITPQ"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U706"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="8">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="306" mass="33900" checksum="F41662B1625E7075" modified="2015-04-29" version="1">MYFEDYLETIDGLPSDFQHNVQRIRDIDAKCQTSNEAVKRRELAFYQTGRLGTTRKELLDEQVVALKQEYAQLAGLAQEKLTIANDTYDMVDRHIRRLDAELKKFADDLEADYPGITPELEKRSLLLDSNSTSTMLNMMVNDGNAASSSTMLAIPNSVVASRAASPGAVMFAVPGLPAMAMASSPTPDSIARKARKSNAERKAEQQAAMSVVPQFDLLDELGAALGTMTDATSAPIAVEVAAEVSDERFCHCRQISHGQMIACDDPYCRIEWFHYGCVGLTETPKGKWYCSDCLANRKRRKSQRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7B2</accession>
    <name>A0A0D2U7B2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348975.1">
        <property type="nucleotide sequence ID" value="XM_004348925.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U7B2"/>
    <dbReference type="eggNOG" id="KOG2076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7B2"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1598" mass="174505" checksum="FDFC70454DF3FFA1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA43</accession>
    <name>A0A0D2UA43_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363820.2">
        <property type="nucleotide sequence ID" value="XM_004363763.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA43"/>
    <dbReference type="InParanoid" id="A0A0D2UA43"/>
    <dbReference type="PhylomeDB" id="A0A0D2UA43"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="818" mass="90455" checksum="1C4830C14BE71A22" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB56</accession>
    <name>A0A0D2UB56_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364121.1">
        <property type="nucleotide sequence ID" value="XM_004364064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB56"/>
    <dbReference type="FunCoup" id="A0A0D2UB56">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UB56"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UB56"/>
    <dbReference type="OMA" id="HCANILI"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UB56"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="312"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="921"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="950"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116501" checksum="DA6661C5FE3F4789" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBW5</accession>
    <name>A0A0D2UBW5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBW5"/>
    <dbReference type="STRING" id="595528.A0A0D2UBW5"/>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBW5"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF133">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN PAC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="352"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="676" mass="73859" checksum="A69BDBF980E11D5D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCB8</accession>
    <name>A0A0D2UCB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NLE1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCB8"/>
    <dbReference type="FunCoup" id="A0A0D2UCB8">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UCB8"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCB8"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="511" mass="55947" checksum="C925BB1F8F2643CB" modified="2015-04-29" version="1">MLRRKPSSAAGANADNSAATADAANKRVRVDGDADVASAIVPAAESAHVVAQFVAEDGSTTGPPLDLPLNVTPDQLRILLNSLLKAEDDTPYSFFVNEEEVTETVHSAFAKQGLSSEVALQILYVPQAVFRVRAVTRCTSSMPGHSDSVTTVAFSPDGTRLASGSGDTTVRFWDVRTQTPEHTCTGHKHWVLAIAWSPDGKHVATADKNSQIYVWDAENGKAKCGPMTGHSSWVNWISWEPVHLNPECRRFATASKDGTVKIWDILQKRCLMTFAQHTNSVTCVKWGGEGLIYTASQDRTIKVWRVADGVMCRSLTGHAHWVNVMALSTDYVLRTGAFDHTGRAPATPEEAKTRALERYNAALAGGRERLVSGSDDFTMFLWDPSESKQPITRMTGHQQVVNHLSFSPDGRYITSASFDKSVKLWDGRTGKFICTFRGHVGPVYQVAWSADSRLCVSASKDSTMKVWDMASKHLKFDLPGHADEVFAVDWSPDGESVASGSRDTMVKIWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCR7</accession>
    <name>A0A0D2UCR7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UCR7">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UCR7"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCR7"/>
    <dbReference type="OrthoDB" id="6778822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="13">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="380"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="852"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="935"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1802"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1802"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1834"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2007" mass="219804" checksum="376C849DC9D1D6EB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UD98</accession>
    <name>A0A0D2UD98_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363621.1">
        <property type="nucleotide sequence ID" value="XM_004363564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UD98"/>
    <dbReference type="FunCoup" id="A0A0D2UD98">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UD98"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UD98"/>
    <dbReference type="OMA" id="ANTIFHR"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UD98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="564" mass="61655" checksum="7DAB6517A5AC6893" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFC5</accession>
    <name>A0A0D2UFC5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFC5"/>
    <dbReference type="STRING" id="595528.A0A0D2UFC5"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFC5"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42205" checksum="8BF95E071FDBD6AE" modified="2015-04-29" version="1">MQAVMDDMNELQRELYDIVKNATEELDLSEERIDVAAAQAIAEALKVNTTLTWLKLEKNQIGDLGVQAIAEALKVNTTLTYLDLDSNQIGDAGAKVLAEALKGHTTLTGLGLNTSQIGEVGAQAICEALKVNSTLTMLDLDANQIGDAGAQAIAQALKVNTTLTWLNLDGNQIGDAGAQAIAQALKVNSTLKKLFLDANQIGDAGAQAIGEALKVNKRLIDLRLSENHIGDAGANTIAAALKVNTTLTWLNLSENQIGNVGAEAIAEALKVNTTLAVLGLHTNEIGDDGACELADALEVNTTMTKLHLDRNCMDYGRSALLDVREDNCRLELTFDDQIGCLAFIWLPRKATAEDVQSVFLLLTSGLQLEDQSACLPALPAETHHKNCKLFQIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFZ2</accession>
    <name>A0A0D2UFZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFZ2"/>
    <dbReference type="STRING" id="595528.A0A0D2UFZ2"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFZ2"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="297"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="604" mass="62854" checksum="3F0FD32D2A130788" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJI5</accession>
    <name>A0A0D2UJI5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346402.1">
        <property type="nucleotide sequence ID" value="XM_004346352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJI5"/>
    <dbReference type="InParanoid" id="A0A0D2UJI5"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJI5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46332" checksum="89FD5F5E06A801D8" modified="2015-04-29" version="1">MQANSNCSTPYLGPNCDVTFAENLGASYQVVQGLLCTLLIGASLFGLVQSYRITCKNGWCTKLDNTVIYLSTLTAISAAIRQVDSSGWRGVYPTWVTSVLYDVSTCFILTVWMRVVLSWATFVSRSVAASFRSRLFQWGYYAAVAYAWFTQLISTLFMFTTGPYWAGKVAMYALLCGVIAAFFCCSFVFAYRIRKLLAQAQARYGDNSASSHRKDNPSSSKGDTSFAISVDGSKIDGAASSAKAKAAEGLASKRRRLAIQRIYRMTMWAMVIQVIGLLALFYNIIKWSTSQYNLDPPHVQPVPKVGDLIVAHIFDLVHFMAAVFFLWYYRVSRSRGQVQSATSESDESAHATSTDHHHQDWATSFISRVEESDHAAEMVYRSPSQMLTGSMEFTHGDAPSLATLPEESEAADVHVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJP3</accession>
    <name>A0A0D2UJP3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346458.2">
        <property type="nucleotide sequence ID" value="XM_004346408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJP3"/>
    <dbReference type="eggNOG" id="ENOG502S0MT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJP3"/>
    <dbReference type="OrthoDB" id="74158at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJP3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF76">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="219"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="364"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="579" mass="63003" checksum="63DB4BAFB7038F4C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKU7</accession>
    <name>A0A0D2UKU7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKU7"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKU7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="446" mass="46978" checksum="0342B4E093E907B3" modified="2015-04-29" version="1">MSDAIEARSRRMLKHITALQSIGLARAAAHHIATVHHAHRDAAAADAADALSAPKSSTSTSSSSSSPSVTAHPAQPVAQGAAAHRRPVAAAGSAVSSALTSLSESLTSLTSLTSIVRAIVQHGSTLSNAGASSSSGSSSALPSGLSSSLASGSSSESEAHHVEAASLKTLPSSPGSFAPSLWLQASSSSLPGPSSSLASASSTLPPSASSSSTSSPAGTATIPSPSDLDAVGDSPQLQRLIEAVARLSAPNAGSAEDDQIASNASVQAVIELLTASIDANAPCLTQRVIGPMPLNQSHDDVQDMRLRITILLAAAKTCTLLWESIFKSALAFTLPLERHVDYWNDKQANPWFYYAQVLPATIFGFGRTLRRNWTFARIVHELLLSPFYKLHQHHAVIHQTKREHIVLLGRLSQWRRALKSSEWEVIMAPLVLVLRERHPRRILIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULD4</accession>
    <name>A0A0D2ULD4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345053.1">
        <property type="nucleotide sequence ID" value="XM_004345003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULD4"/>
    <dbReference type="InParanoid" id="A0A0D2ULD4"/>
    <dbReference type="OrthoDB" id="381520at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULD4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002395">
        <property type="entry name" value="Kininogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00334">
        <property type="entry name" value="KININOGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37929" checksum="72C011E7849A7B17" modified="2015-04-29" version="1">MSHHGHSHDGGRCSSSQHHGSGAGHGHSHGGDSELSHHGGHGHSHSSGASSSHGHGHSHDGGHDSHGHSHDNHGHSHDGGHGHSHDGGHGHSHSGSASGSSSGHGHSHEGGVCPSSVPVSPEQQKYMSKLQELVEAQRFDELPPVIAEEAARTISEVGRNSDAYVKFLQRSGMLCFQLGLYTTAEGYGKEALEILTAMYGPDDLHTALGRLNLGLYKCPLDKHQEAEALYLSALVTRVKLLGKEHRDVAQVYHNLALLYRNTAQWSKAGPQYERSLEIWHRQRAIQEWMITQRDYIEMFELQSKWTEALEQMDKLLKFTDAAVTKSHPIYEKFASDRDEIVAKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP26</accession>
    <name>A0A0D2UP26_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UP26">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP26"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP26"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="85"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="815"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1317" mass="143279" checksum="87145E5067EB586E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP61</accession>
    <name>A0A0D2UP61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_007051</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343775.2">
        <property type="nucleotide sequence ID" value="XM_004343725.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP61"/>
    <dbReference type="eggNOG" id="KOG1169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP61"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEP" evidence="17">
        <location>
            <begin position="225"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="16">
        <location>
            <begin position="437"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="17">
        <location>
            <begin position="805"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1045"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1542" mass="168443" checksum="2473E5969932EB5F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPA8</accession>
    <name>A0A0D2UPA8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343826.2">
        <property type="nucleotide sequence ID" value="XM_004343776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPA8"/>
    <dbReference type="FunCoup" id="A0A0D2UPA8">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPA8"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPA8"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPA8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="472" mass="49752" checksum="B4FA4454F21E2A64" modified="2015-04-29" version="1">MSLNPGDTAWVLVSTALVQLMTPGLSFFYAGLVNSRNVVGTLMLSYGAMGVVTFLWVIIGYSEAFGPSTNTHVTGGTENRALEGLVGGMVGDLPALVYAMFQLMFAIVTAAIISGSVATRMRFIPFMTFVALWHLLVYCPLTHWVWTVGDGWINDYGAIDFAGGLVVHVSSGVSAFVAAFWLGQNPLRDNVHEHKPHNVPYVMLGAALLWFGWFGFNAGSALTAGQLAGLAFANTQIAAAVAMFTWNLVEVICGGKGWFNGRPTAVGAAIGAVVGLVAITPAAGFVTPMWSIFFGAFTSPVCYLALKLTKRSPIDDTLDTFAVHGVGGAVGSLLTGLFATTEVGSPVDGSFYGDGGELFGKQIVALLATIALCLVMTSLIMLFLKGMAKLLHTDIRISADDMAVGVDGIDHGESAYGHADIEAVIAALQRANQQGLLQKGSTFELVPTSAPKNKRDSYPVTQFDTATAQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPZ2</accession>
    <name>A0A0D2UPZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tail-anchored protein insertion receptor WRB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343417.1">
        <property type="nucleotide sequence ID" value="XM_004343367.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPZ2"/>
    <dbReference type="FunCoup" id="A0A0D2UPZ2">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPZ2"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPZ2"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20196" checksum="BE3572C307EF96CE" modified="2015-04-29" version="1">MIFDVAAVDVFLFLFLFEFMRRRSAQIAAWVLDKVQPQSESASERETSELQRQVDELTEQQRPLSMQDDFAKYMKIDRQLIKLKKELQTRRAAASTAVKYNSKKLTSVVWWAALVFQGLLMYRYRGTVIFSLPSSSVYPLERLMAYRSGGELGSISGVIWILVCRRVVSVVLDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URR4</accession>
    <name>A0A0D2URR4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_010146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URR4"/>
    <dbReference type="STRING" id="595528.A0A0D2URR4"/>
    <dbReference type="InParanoid" id="A0A0D2URR4"/>
    <dbReference type="OrthoDB" id="6138780at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URR4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="191"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="784" mass="80617" checksum="A3BF2935934D4557" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFB8</accession>
    <name>A0A0D2VFB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364946.1">
        <property type="nucleotide sequence ID" value="XM_004364889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFB8"/>
    <dbReference type="eggNOG" id="ENOG502S6EG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFB8"/>
    <dbReference type="OrthoDB" id="2162799at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1120" mass="119386" checksum="98785B1D056DDED9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG60</accession>
    <name>A0A0D2VG60_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xaa-Pro aminopeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG60"/>
    <dbReference type="FunCoup" id="A0A0D2VG60">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VG60"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG60"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="323"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="553"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="617" mass="67382" checksum="3D25C521C8223934" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGC0</accession>
    <name>A0A0D2VGC0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGC0"/>
    <dbReference type="InParanoid" id="A0A0D2VGC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="255"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="520" mass="54607" checksum="E35543DDC854FC3A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGV8</accession>
    <name>A0A0D2VGV8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DALR anticodon binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365520.1">
        <property type="nucleotide sequence ID" value="XM_004365463.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGV8"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGV8"/>
    <dbReference type="OrthoDB" id="9990834at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106217">
        <property type="term" value="P:tRNA C3-cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037380">
        <property type="entry name" value="DALRD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16043:SF1">
        <property type="entry name" value="DALR ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16043">
        <property type="entry name" value="DALRD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="2">
        <location>
            <begin position="484"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="646" mass="69191" checksum="A67CACA534311F79" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIA4</accession>
    <name>A0A0D2VIA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KxDL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270046.1">
        <property type="nucleotide sequence ID" value="XM_011271744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIA4"/>
    <dbReference type="STRING" id="595528.A0A0D2VIA4"/>
    <dbReference type="eggNOG" id="KOG3443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIA4"/>
    <dbReference type="OrthoDB" id="10258877at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="3">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="18973" checksum="16DB9C3BBB3A551A" modified="2015-04-29" version="1">MTDELSGQAPPPPPLDASTVFANKITSGIDHGAVNDMLRQQRLILGRFERTNARLSRFNEHLDSVLGAHTARFKSYTHQLVDAKKDLESIFRRIRALRAKLTQQYPEAFFGLEMPGNISDDDDDDYGDEDEEHDPRSKTAARPQHPVEQESAATESSEVAAPADDGAAPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ80</accession>
    <name>A0A0D2VJ80_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polymorphic outer membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ80"/>
    <dbReference type="STRING" id="595528.A0A0D2VJ80"/>
    <dbReference type="InParanoid" id="A0A0D2VJ80"/>
    <dbReference type="OrthoDB" id="541289at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJ80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31318">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253630" description="Polymorphic outer membrane protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="81576" checksum="69F8404C98DCFDFA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL05</accession>
    <name>A0A0D2VL05_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348771.1">
        <property type="nucleotide sequence ID" value="XM_004348721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL05"/>
    <dbReference type="STRING" id="595528.A0A0D2VL05"/>
    <dbReference type="eggNOG" id="KOG0248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL05"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="663"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="793"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1226" mass="130237" checksum="0B650802D9469FC8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM53</accession>
    <name>A0A0D2VM53_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM53"/>
    <dbReference type="STRING" id="595528.A0A0D2VM53"/>
    <dbReference type="InParanoid" id="A0A0D2VM53"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="920"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="837"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="978" mass="103820" checksum="DCB1FD68C2038BC6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMU9</accession>
    <name>A0A0D2VMU9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349400.1">
        <property type="nucleotide sequence ID" value="XM_004349350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMU9"/>
    <dbReference type="InParanoid" id="A0A0D2VMU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="184" mass="20601" checksum="3703BF8C0AC1EBCF" modified="2015-04-29" version="1">MTVNMFSRFGFASSTNHPAQVDVLPPAPHDRQPQHGAGHLHYAHNVVATTAVVHTGKHAEVKLQFPLRTSPPQDVPPRPSLGSRDDDRILSCKFCERTLRSVRTICGHCQYVHTGDGRHVRVKLCDATSSLGGLAHFGSQQSRLSHQQLHRPLASYHNSQLPQEHRVQPVRDTSDDQELQFEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNJ2</accession>
    <name>A0A0D2VNJ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363795.2">
        <property type="nucleotide sequence ID" value="XM_004363738.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNJ2"/>
    <dbReference type="STRING" id="595528.A0A0D2VNJ2"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNJ2"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNJ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="385" mass="40576" checksum="6F4D87DC7AB0A3CD" modified="2015-04-29" version="1">MEPVPTLLLFSLAMLVGSYVAGLLPLSVKLSESRIKFMTALGAGLLVGAALAVIIPEGVNALYMPREPSAELLAAHAADPHAGHDHGNDGSITSRFRNFFAPDDPQAAAEAKQNRRGQQLLPWVAERQDNAQQDAVVPLVPQADPSIGGQRRLQAAAEEHNHNHEDEACPHPSHSGIGASLIFGFILMLLIDRISSGSGHGHSHGLPSSSSNNNEKSVTTTVGLVVHAAADGIALGAAVASQRSSVEMLVFLAIMLHKAPSAFGLTSFLVHEGFDNRRVRKHLLIFSCSAPIGSIVTYLFLRMGGNTLLQMDPSTATGYALLFSAGTFVYVATMHVLPEIMHVHPASTSASNASGSGDGSLSRDQFCALIVGMVAPLFMSIGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNQ0</accession>
    <name>A0A0D2VNQ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363859.1">
        <property type="nucleotide sequence ID" value="XM_004363802.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2VNQ0"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNQ0"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNQ0"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="24131" checksum="10A5B9B18FF9A97E" modified="2015-04-29" version="1">MSVVNAASVAVALSIAACVTGIIVNDVHMVQILQHHSPLFCWIFAIVYLVELVAIRSRRRLSIQSYTMTGRAPPLVPPIRQGLICTIASIFCFHIVFVLMGAPVVFNMTKTAALAAMLAALAVGPTALNFGFAQPPHSAATTSTPTNVLDALIYTFFNDSPDITDAKLSFWSACIGAWLGAIPIPLDWDAWWQEWPISVCLAMPATVILAWVARATVIRPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNR2</accession>
    <name>A0A0D2VNR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNR2"/>
    <dbReference type="STRING" id="595528.A0A0D2VNR2"/>
    <dbReference type="eggNOG" id="KOG4285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNR2"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12441">
        <property type="entry name" value="RRM_Nup53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="304" mass="32147" checksum="F21011329D4E9F4D" modified="2015-04-29" version="1">MSATPGRFLSTHFSGQANTGQSPTATTSMGASSSFMGSRGDFGQRPPRAISMSPDAGATSQVFGTPLTAGRSRHSISTPATGRAPPGTGARSMARPYGAAGAGRAQMQDTAYAPPLESLYDDYDSAVPFTAPSAAEAGFERSFAAHLPSDSIDALSDIAPAEGDNSLDVWVTVFGFPPTAASLVLSYLEQCGDIVRHMMAPDGGNWMHVRFKSHLQAERAISRNRKVVARSIMLGVAPCEDRGVLAGDKSAAAGLDLTAPRALHNASQRSRRDIDVFSTGYTSKAPQKVNPSLFRQTIEYIFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPJ8</accession>
    <name>A0A0D2VPJ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylmalonic aciduria and homocystinuria type D protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364233.1">
        <property type="nucleotide sequence ID" value="XM_004364176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPJ8"/>
    <dbReference type="STRING" id="595528.A0A0D2VPJ8"/>
    <dbReference type="eggNOG" id="KOG3994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPJ8"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPJ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27983" checksum="924900B68AE7B6CC" modified="2015-04-29" version="1">MPLLPPTVLQLPSSSTTASALPRPPPMEVSVHACPTYMFSEVQRVFPQPLERERLLILPVILRSTNDLVGMGPAVEAEKDALLEIFMSWASRVCELLGERGHWADMTDPCSGYPVYGERGASCYPDVLANELLLKYPVINTGCCKIMSHPKWHTRIYPATVFSTAPLAELLRCIEIASGTALPVTAAEESPQTDEQQEQAGENTNNACSGNVEATLCTNPTGTPDSSTGIYVAAPSAGLSVPQKNSYWPHRPPLAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPZ6</accession>
    <name>A0A0D2VPZ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348431.1">
        <property type="nucleotide sequence ID" value="XM_004348381.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPZ6"/>
    <dbReference type="STRING" id="595528.A0A0D2VPZ6"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254394" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118629" checksum="E48EE78DAB7B419B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRL6</accession>
    <name>A0A0D2VRL6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348127.1">
        <property type="nucleotide sequence ID" value="XM_004348077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRL6"/>
    <dbReference type="STRING" id="595528.A0A0D2VRL6"/>
    <dbReference type="InParanoid" id="A0A0D2VRL6"/>
    <dbReference type="OMA" id="PSANWNA"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1276" mass="133132" checksum="3073308CD57229EC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTZ3</accession>
    <name>A0A0D2VTZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347074.1">
        <property type="nucleotide sequence ID" value="XM_004347024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTZ3"/>
    <dbReference type="eggNOG" id="ENOG502RAJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTZ3"/>
    <dbReference type="OMA" id="YWVNYDI"/>
    <dbReference type="OrthoDB" id="192566at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="626" mass="70135" checksum="16408EA3FB3E955F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUT9</accession>
    <name>A0A0D2VUT9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUT9"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUT9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254516" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="74589" checksum="E135F522D4F08490" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV32</accession>
    <name>A0A0D2VV32_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_005756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV32"/>
    <dbReference type="STRING" id="595528.A0A0D2VV32"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV32"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="281"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="157"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE95287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="625" mass="68706" checksum="6019F79639607A4B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW01</accession>
    <name>A0A0D2VW01_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW01"/>
    <dbReference type="InParanoid" id="A0A0D2VW01"/>
    <dbReference type="OrthoDB" id="427001at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25411" checksum="961361D2D4A43E4B" modified="2015-04-29" version="1">MTERQRELFNKGKNASGELSWSRWQLGDAGAQALAEALKVNTTVTRLHLYENQIGDDGARAIAEALKFNTVTAVALSQNAIGNAGAKAIAEALKTNKTVKELFLGENQISDSGAQAIAEALKVNTTLTELDLQRNPTGVAGARAIAAALKVTTTLTWLSLDQNQIGDTGAQAIAEALKINASVTTLGLGWNQIGDAGAQAIAEALKVNTTMTSLHLAYNEIGDAGAQAIAEALKVNSTLTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWE8</accession>
    <name>A0A0D2VWE8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345039.1">
        <property type="nucleotide sequence ID" value="XM_004344989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWE8"/>
    <dbReference type="STRING" id="595528.A0A0D2VWE8"/>
    <dbReference type="InParanoid" id="A0A0D2VWE8"/>
    <dbReference type="OrthoDB" id="10063829at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWE8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE95897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="11985" checksum="06C477084556D7A0" modified="2015-04-29" version="1">MSKVLAALKRIVTVYPILPHSFRYQGVNIVSRSQPLPNLPPGVAHKLSKNYYWNRDDRRAFTPSKVIGNATSQPLLTSETAAAAPAAVAASSDALPPVINSQRPFAIASFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZN9</accession>
    <name>A0A0D2VZN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_010107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZN9"/>
    <dbReference type="STRING" id="595528.A0A0D2VZN9"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZN9"/>
    <dbReference type="OrthoDB" id="2804215at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="866"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1144" mass="118045" checksum="562381730358C371" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1X5</accession>
    <name>A0A0D2W1X5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346398">
        <property type="protein sequence ID" value="KJE98357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341227.1">
        <property type="nucleotide sequence ID" value="XM_004341179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1X5"/>
    <dbReference type="InParanoid" id="A0A0D2W1X5"/>
    <dbReference type="OrthoDB" id="4156109at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="273" mass="31330" checksum="4D75CE49A8021BE6" modified="2015-04-29" version="1">MSGVFDLQLLHIASQIARGEKIPTHLTGLAKVIQGLSTSFLSYAARNRMDWNKREAQRLFAPEQGGSYDVWFTRPLSAILIEYLTDVHIFSHLLTALLPEDQRAIHRPAIERASSRRLNIAHALDFSKDNPRNKLVDDEPFIDEIVSNCSSSVRTRISNERAELLRIQALPVKDRVRTRGGGPSAMQEVSEALRGHRTIQPVILWDVVQFICAHNRWFSSEDYMAFLELAMSSYYLTIKQRQTCSDWRSRNGAHKNQRYTDDECYDYDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGL2</accession>
    <name>A0A0D2WGL2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGL2"/>
    <dbReference type="InParanoid" id="A0A0D2WGL2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="101" mass="11478" checksum="3144EB59B928EFFF" modified="2015-04-29" version="1">MINTKAMLPRAMLTSTPKQHSKQSKVKVLNKIIKNNHQFKKSSECRCCVCGEEQARRGERDDRQLQTKEGLANQLARAKKKNSALNAVVDNNLNSKKKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIC9</accession>
    <name>A0A0D2WIC9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365889.2">
        <property type="nucleotide sequence ID" value="XM_004365832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIC9"/>
    <dbReference type="InParanoid" id="A0A0D2WIC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="464" mass="48377" checksum="940D640E464042C3" modified="2015-04-29" version="1">MFALSLPSATCRRAVARMPLRTLHNYPGRARASSLSPAMTSTMRSAATAAYADPSETTPKLILPATSSSSSSAGADAPLHSLDFVHLPGVVFPGQAVAVVVSAPAVARWLLRSAAASSAPSSRFSHLTSTGNHGAQPQLLRHPSSSDTATTATAAASRFEFGYAAGLPKPTVGDLPTLGSAAVTASLAAAAAATDVATAIRDIQATDIDVADAPADVADADAAVEGELTPVWLSAFQPAPSTQQQQQPASSSSAQPNGASLGICVASVLPNDPTLARQTVKVLLDNLGRVQAPDVGCQMQLESVEPLQDGSVRVHARATHRIDIDSRRMTDAGVWRCGVHQMEDAAFESADESAHALAVAQSICARLLSRVQSMPAGNAAVDAYLPAWRQALQFSEMTLTDLQTRGPTPVAASLHATLSTLSFYFAWITSATCELSPYRQQQLLNTRVIRERLLLVSSALAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ01</accession>
    <name>A0A0D2WJ01_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365549.1">
        <property type="nucleotide sequence ID" value="XM_004365492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ01"/>
    <dbReference type="InParanoid" id="A0A0D2WJ01"/>
    <dbReference type="OrthoDB" id="10015561at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254996" evidence="1">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="264" mass="28755" checksum="4F1889B8BAD09B7C" modified="2015-04-29" version="1">MQAQQLRGWSAVAVGVVLAQIGLLAISVAAPPPPQPPAWPSAFNTCVSMYVSSSDRDFVRAGWYLDEQHQAVRLDSYGVPLAVLCDRQRRNTLLAGRFAPDPSLGSQALDRMAKHVAGQCGEADGKSFADEQPPIAIAAGVGTCQLGPPLYVFIWHFDLGIEWFIAPGPEGSICHQSNITAKFPAPLNFDSRAVFQETSVVNGTELWHWRTDYFLFSVDAYFRTNDSTPYQLIYATSSNLFSTFNPGPQNSSLFEPPSGVICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ24</accession>
    <name>A0A0D2WJ24_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ24"/>
    <dbReference type="InParanoid" id="A0A0D2WJ24"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="105" mass="11797" checksum="A7EA0009DA58E9BF" modified="2015-04-29" version="1">MSVAGTRARTHTYRMPLGGGRSKGERERKKKPTVDRKKKKIKHQFEITTNRPCEWNGNGRESAGQSKGGGRGLRTCNVWQTLRRSEAAPPTSINPPSTDPRPERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ92</accession>
    <name>A0A0D2WJ92_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364308.1">
        <property type="nucleotide sequence ID" value="XM_004364251.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ92"/>
    <dbReference type="InParanoid" id="A0A0D2WJ92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="977" mass="106666" checksum="C4C76B5BEFB69319" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJL5</accession>
    <name>A0A0D2WJL5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane anterior posterior transformation 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270109.1">
        <property type="nucleotide sequence ID" value="XM_011271807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJL5"/>
    <dbReference type="STRING" id="595528.A0A0D2WJL5"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJL5"/>
    <dbReference type="OMA" id="AVYISEC"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJL5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="77567" checksum="6BC2212E001A912B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK38</accession>
    <name>A0A0D2WK38_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364711.1">
        <property type="nucleotide sequence ID" value="XM_004364654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK38"/>
    <dbReference type="InParanoid" id="A0A0D2WK38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="335" mass="33943" checksum="7BEE8766B0AA8F6F" modified="2015-04-29" version="1">MTVLSTGALLVKPVPVECSAEDVLAAMKESLGELGATALAATLDRPSCIVEFPSQDHARAALASLRSQLWIGDVGARVVLHSVPQPPAALIVRPVPAGKSADDVLACMRDSLGSQFAVSAAISASLESAVCTVLFPSDADATAALQQLNSQLWFDDVGMRVSRPTHQIAARAVPKTTQSHPPPSAAAAAAAAAALSPAPTSVPQPAPSAAPAPHHAFAPPAASSNPQLQANPFATPVVASHNPFATPDASQNPFATLVASNNPFATPIASSTAAPVATQSSYMPMPAPFDSFAHHATHPHGAGYSAGQQDYRSTGVAGQVPESFGLVAPLASFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKY7</accession>
    <name>A0A0D2WKY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKY7"/>
    <dbReference type="FunCoup" id="A0A0D2WKY7">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKY7"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKY7"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="12">
        <location>
            <begin position="478"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="550"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="590" mass="63869" checksum="30BD182E90759785" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLD7</accession>
    <name>A0A0D2WLD7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLD7"/>
    <dbReference type="STRING" id="595528.A0A0D2WLD7"/>
    <dbReference type="InParanoid" id="A0A0D2WLD7"/>
    <dbReference type="OMA" id="TTIRVFW"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLD7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="213" mass="22317" checksum="C0AF0C11F66AB525" modified="2015-04-29" version="1">MVSQDDEFDALLMQEDALQHAGAVAGEDAGRLAGIAEGRQLGLVKGTQLGAEVGYMRGVAAALLELSPTNAAPVQVQVPAGSSDAAAATDASASTESSGDDDTRSTSPTRPAGLSMRTRKAAEAVIALADGCSLENPHEDKLFETLDRLRAKFKQLTSAAGLNLRFDSSRPHSHDASTGGRASVPQLLPQNRTTIRVFWQDDDVADFRGTQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLN3</accession>
    <name>A0A0D2WLN3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348835.1">
        <property type="nucleotide sequence ID" value="XM_004348785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLN3"/>
    <dbReference type="STRING" id="595528.A0A0D2WLN3"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLN3"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="207" mass="21955" checksum="1E39B9238607F4D2" modified="2015-04-29" version="1">MSTTTTTAAIRGKSTAATPTAASASTAAGTTTATTSATATATTEQQQQQQQQQQQQSKAAEQELPPTSTQTDRLTQLQDRISQMAEMLFTSVGVLKDFRPTDAASQTATILPAGAPAPSGMSLQQYEEFAQTHASMIARTAKEIDVLIDSLPEMHVDAEDELQMFANLHKQNADAGIAFGETVNLAEAHLTAVKQALHFVASQQVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLS2</accession>
    <name>A0A0D2WLS2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal glutamine amidohydrolase alpha beta roll domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLS2"/>
    <dbReference type="eggNOG" id="KOG3261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLS2"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="5">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="61397" checksum="B97CB33B7546D071" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLU7</accession>
    <name>A0A0D2WLU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_002718</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349468.1">
        <property type="nucleotide sequence ID" value="XM_004349418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLU7"/>
    <dbReference type="FunCoup" id="A0A0D2WLU7">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLU7"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLU7"/>
    <dbReference type="OMA" id="FERCDES"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLU7"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="92"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="452"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="62963" checksum="C145942FE961EA6C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLZ4</accession>
    <name>A0A0D2WLZ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLZ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WLZ4"/>
    <dbReference type="InParanoid" id="A0A0D2WLZ4"/>
    <dbReference type="OrthoDB" id="8861968at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270029" description="LRRNT domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="903" mass="89055" checksum="ADCC31770A820DBA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM49</accession>
    <name>A0A0D2WM49_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270258.1">
        <property type="nucleotide sequence ID" value="XM_011271956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM49"/>
    <dbReference type="STRING" id="595528.A0A0D2WM49"/>
    <dbReference type="eggNOG" id="KOG1090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM49"/>
    <dbReference type="OrthoDB" id="6020705at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF10">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="47738" checksum="BC58B9128093AF92" modified="2015-04-29" version="1">MNFLQFFERPPATAPPDASSPHSSMSTSRSGSHSSSGSSHSSTHSNTHSLGLTSNPKSAEHRTGWLTKIGGNIKTWRRRYMILNVLDGKLSYFRTPGDTAPLGVIDVQHSQAVYMAPSCETHREHCIAIATATRTYLMYGDTLNETEAWLHDLRVVGGHHHHHQQQSPTGASPSTTGADDGSSEPSAVLQTTAAAPSARRSVVESDQLAELVKDDAVAPDGDQRRDADQPATVNRQPSPRIASTGSSEATLSDLPLGSTALHSPRWPQQSQLTCEVCSQRFKFDDGSTCTHHPGWTLSAVSTWGLCSLCKMPWTPSGGCTQSRHTFTRSQRSASGSLFSSRAQRSNTTIGLPDASNSAAPLRDVYSKEQCCFALLRMLSAGTSPVTISRWAYRVLIMSFDLLEDGVEQPLLRLISMDESNPLSYDSMLALARELQSAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMI4</accession>
    <name>A0A0D2WMI4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003076</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363915.1">
        <property type="nucleotide sequence ID" value="XM_004363858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMI4"/>
    <dbReference type="STRING" id="595528.A0A0D2WMI4"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMI4"/>
    <dbReference type="OMA" id="GXIVSAV"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMI4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MARK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="60"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="18">
        <location>
            <begin position="799"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="393"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="393"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="463"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="848" mass="90447" checksum="8C9CE2B3EBEDE3E4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMS8</accession>
    <name>A0A0D2WMS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyruvate carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008680</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WMS8">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMS8"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMS8"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMS8"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="293"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="414"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="825"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1364"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE92245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1443" mass="154647" checksum="28E5CE64121F05E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP53</accession>
    <name>A0A0D2WP53_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364189.1">
        <property type="nucleotide sequence ID" value="XM_004364132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP53"/>
    <dbReference type="InParanoid" id="A0A0D2WP53"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="166" mass="18048" checksum="5A55222148EE47FA" modified="2015-04-29" version="1">MAELSTNEMKQLLEERTKGMAEARDRAAQYELNLREKRAKLLEGKTLTTADATSNVKVSDLKQENSELAAKLAGVTGSRALSAEEKLAAAAEQKRRANDPEVQAELRRIDAQIRALGGNPDDDYKPYVVNETVIKEGPKIVKSMFDNIFADLGSFGAPADGDAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPW1</accession>
    <name>A0A0D2WPW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348140.1">
        <property type="nucleotide sequence ID" value="XM_004348090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPW1"/>
    <dbReference type="InParanoid" id="A0A0D2WPW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="292" mass="30861" checksum="B415DE124A3726F3" modified="2015-04-29" version="1">MSNYPTAIQPGANRPSASSSSSAAAARPDGSSRSRELLDSDENRTHYPHWYSDAMDAGPSSMVVDPAGSAFNPMHATRTRQPSPLASRAPPPSPMSFFQQQLTAGALNFSSPRGPLASQTGREQPSQLGAQRVRFGAQSSPTLTALRSDQADRGASATPSSSAALLSSYSAREAAPGFAGSESLANSEFVRRPESGAASGEAAAVDSVLEEQQLQRFRELASSLGREGDLEARVSAIESCLSLLATDSKPLFGLVARVTAMEEFLAKHYVELIAHIEALERELDLLSKNAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ83</accession>
    <name>A0A0D2WQ83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ83"/>
    <dbReference type="InParanoid" id="A0A0D2WQ83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="226" mass="25381" checksum="13302CAF7274E5DB" modified="2015-04-29" version="1">MLQPCGKTKAANHAQQPFGVDFRARPKVKLISADLALEPVDHSLELIERLAKILKQCLDSISKDLANPPSKPDLWERLVVHLFNLRVTAYLAQRVLSASKPPSGAILVPLIKLLPGVKFSDDCKNLSLMLDPNTWDTDVFVQLAPENEPGIDAYMHADLAGHATKKRVVIGLQMKLHMHLQSPGPAELSNYEQWARQRLDQSYLLTLLSTRGCWSVTRWTNSRKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRC7</accession>
    <name>A0A0D2WRC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346763.2">
        <property type="nucleotide sequence ID" value="XM_004346713.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRC7"/>
    <dbReference type="OrthoDB" id="2112804at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266525" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="13">
        <location>
            <begin position="40"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1298"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1396"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1455"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="1233"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1518"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1550"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1586" mass="170875" checksum="82FC648C8073459E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSB3</accession>
    <name>A0A0D2WSB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270500.1">
        <property type="nucleotide sequence ID" value="XM_011272198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSB3"/>
    <dbReference type="InParanoid" id="A0A0D2WSB3"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="570"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="887" mass="97075" checksum="AE2AB434B15CF31C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSE4</accession>
    <name>A0A0D2WSE4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSE4"/>
    <dbReference type="STRING" id="595528.A0A0D2WSE4"/>
    <dbReference type="eggNOG" id="KOG4705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSE4"/>
    <dbReference type="OMA" id="WFINESA"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSE4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="98"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="320" mass="34706" checksum="09C2AFFEB308A461" modified="2015-04-29" version="1">MSVRASARAADAAAKKAASTTSMAAPQGQWVCLMPEAVVAREGSTSLATMPHPRTAPDGKVQLYELQSCDSQPRSWFVGQTVQQDGRLFVSTLIDPLFLALGILTRLDSKMFLDITQALDVQDFPATRVLSTCISPQSAERICDVKDLGGLVVIRLNQERADNWLQGKVTRLAAYLKTTTVAVGSAVQASSLQRAGTEADYLKYAVGMISEYLDPTCSARLAERNGVQLVEEKRAGKATHSERFADEDKEETPEEAAKRAKEDEFFKSTPKAKPAEQAEKASDEEICKVKLTSVQRSLAKADTKGVKPISSFFGGVGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSL4</accession>
    <name>A0A0D2WSL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-1,4-glucuronyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">I-beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Poly-N-acetyllactosamine extension enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_005102</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46860"/>
            <dbReference type="Rhea" id="RHEA-COMP:15023"/>
            <dbReference type="Rhea" id="RHEA-COMP:17482"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:142405"/>
            <dbReference type="ChEBI" id="CHEBI:177336"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 49 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346787.2">
        <property type="nucleotide sequence ID" value="XM_004346737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSL4"/>
    <dbReference type="STRING" id="595528.A0A0D2WSL4"/>
    <dbReference type="eggNOG" id="KOG3765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSL4"/>
    <dbReference type="OrthoDB" id="9974378at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSL4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043189">
        <property type="entry name" value="B4GAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420:SF1">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE94463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="474" mass="54447" checksum="8B3E78A5C6F92F9D" modified="2015-04-29" version="1">MQCCRRRRSTFALTAVILVTGAIAFVMYKDALHFPGPAAVKAPVVDGNNEFDRSGSAPNDSRRSTSTAPKAESGESLHSDPLYQLRVELDAQNLLNEQAMEPAPTFETREQFEQVLSQLPLDESSKYRIHMHYVRRQIAIEQPDVTLVSQCDADHLHEAIGLAQYWDGPVSVAVFIPGNVYKALATLRQIRACHDRVRERVSFHLVYMENESVYEEVAASELPLEGACENFQDPYEELRANNGTAVRPKLQQQKAPAKYDGVPYPNNFLRNVARSGVSSTFMFVIDIDMRPSRGLRLWFLRLADKRPRASLRTAFVVPTFELKAGAPIPRIRQQLIDTYLQGNARPFYEKACWKCQKPTDFDQWLSVTSPISKPTYKVDWKDPWEPFYISWTNLPLYDERFQRYGFNRISQVCETWVSGFNFEVLTGGYLLHEGFKEPESFHTQKSQENDANRSLFRQFKQDLKSKYPSSTRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT25</accession>
    <name>A0A0D2WT25_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345529.1">
        <property type="nucleotide sequence ID" value="XM_004345479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT25"/>
    <dbReference type="SMR" id="A0A0D2WT25"/>
    <dbReference type="InParanoid" id="A0A0D2WT25"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT25"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254642" description="Tim44-like domain-containing protein" evidence="4">
        <location>
            <begin position="31"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33843" checksum="22FC59C92026CB5C" modified="2015-04-29" version="1">MLVRSALNPQSTGSALQLLLLLPVAPTAAAARMHGGSVAQRIHFRSQSSASASASASASALAVHMAARGRGRLGSNNPIQTTTLATLTTLNALAAATTALTAHARALHSQSTPALARPGRLNPLVAQSLSASMSGGLILSKDIPVGPQPPLYTLAGLKSRWNRLRRRVQNFGSAAYLRKLDGEFGRATFAPIAQTLANEITTCVATGQHTRLQALTSQRFYEQLKKAPKSPTGAPIIEQVDKPKIVSIQLVNATAQTMLAQVTVELSQKENGHHAFKYPVFERQLRLDASKTQALSCTPWIVIGKVDPPTEPITTTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU86</accession>
    <name>A0A0D2WU86_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345272.2">
        <property type="nucleotide sequence ID" value="XM_004345222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU86"/>
    <dbReference type="SMR" id="A0A0D2WU86"/>
    <dbReference type="InParanoid" id="A0A0D2WU86"/>
    <dbReference type="OrthoDB" id="61288at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU86"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="98"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="407" mass="44113" checksum="06560CB398D2DC20" modified="2015-04-29" version="1">MSGTAATASGCPVAHHGMRSNGAVCPVTGISSGSADDSPRSRSRSGSISSTSSGQSQGSQLSSSASVLSAQSALSSRSASSGMSGEFGESFSTQMVDLLRHETRDVIKSTWALAIQKQDEADVTPVATFVNVFFGKLFELCPETRLVFGQDLSLQGKSLSSVLTGMLEFVVHPKKLTTQVKSLAVKHVGLGITPDMFDAFGAALVYTIKTRIGKVWSPQTERVWVDAYGGVNNIITQQMSRVTLNSQDIPPWMIQRYQEHHAVLHASWVKATEGDNGDAVLTGFLVRLQSNNPQATLIYERADPRMRKVIIWTAVSKILDCMQNPRSLRKELKPLGQSHAKMGVTGPMLDSFGVALRAVLKDVLKARYTTETDMVWRRCYRLFSVQFLASIEAESKGKGVGKSCGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC3</accession>
    <name>A0A0D2WVC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVC3"/>
    <dbReference type="FunCoup" id="A0A0D2WVC3">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVC3"/>
    <dbReference type="InParanoid" id="A0A0D2WVC3"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVC3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="264"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45107" checksum="2CB3BE1D80215434" modified="2015-04-29" version="1">MKPIELCIVGGNAASNLLSMDVDCLAAVTYTKFVRPPTSAALLHSAPVLSINVCNNPYFAPTGALPALVVPPPVEPDATPSFHAEDVQVVSGLEPVLDNLRGLYGARDPDTILFSPNSATNAHLISAKARAFASLVQDALHDAVEYEQWCHPVNYTTHTRRWFADHSPFPLNYLVPRQRRQTVLDRLVLKYPEPDGDTATSSLRSLIGALTGSSSAASSGQSASSSSRFSLLQSRPAQSTVAASDVASHTHSLHFDEERLYRNAREALLAISQQLGRDGRFLLGDHPCYVDALVFAHLHMIFNSKLPSSRLAETARSYNPLVRYCERMYASLFASDISTYGAVTTSEAQSAIDEKRLLRTRAWQFGLASIVSTIAYLFLSGQVVISAADDDDDDDGNAHAGVALDDDDDEAVDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWA8</accession>
    <name>A0A0D2WWA8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="3 8">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="3 8"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343749.1">
        <property type="nucleotide sequence ID" value="XM_004343699.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWA8"/>
    <dbReference type="STRING" id="595528.A0A0D2WWA8"/>
    <dbReference type="eggNOG" id="KOG1559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWA8"/>
    <dbReference type="OMA" id="EPVSSHF"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWA8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000024">
        <property type="entry name" value="Folate gamma-glutamyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254835" description="folate gamma-glutamyl hydrolase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 8">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="314" mass="34204" checksum="39230E1FA053FE91" modified="2015-04-29" version="1">MQLGGGLLWVGIAAILCIAASSVDAATTTRPIIGILAQPGPNTGEQYIAASYVKYVEAAGARVAPIFYNETADNVRTLVASLNGVLFTGGGADISVGTQFYSTALVIYNTILQLNDAGIYMPLWGTCMGFELINNLVSNANVLGSVDAENYTVALDFTPEFAYSRMFGRAQPIIIQNLATKNITMNNHMLSVYVSTFNATAALTSFFNVLSTNYDRQGVHFVSSIEGKKYPVYATQWHPEKNQFEWVNEVIDHSADAIYTMQYMANFLVGEARQNSNRFANAAAESSALIYASARHLYDSGETADASFEETYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWD8</accession>
    <name>A0A0D2WWD8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anillin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343795.1">
        <property type="nucleotide sequence ID" value="XM_004343745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWD8"/>
    <dbReference type="InParanoid" id="A0A0D2WWD8"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWD8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="2">
        <location>
            <begin position="329"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="602" mass="65441" checksum="59EAC1F1FB009232" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWM8</accession>
    <name>A0A0D2WWM8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343128.1">
        <property type="nucleotide sequence ID" value="XM_004343078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWM8"/>
    <dbReference type="InParanoid" id="A0A0D2WWM8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="106788" checksum="0EF34F2F0D9E819C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWR2</accession>
    <name>A0A0D2WWR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_010071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWR2"/>
    <dbReference type="STRING" id="595528.A0A0D2WWR2"/>
    <dbReference type="InParanoid" id="A0A0D2WWR2"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="436" mass="46551" checksum="45FFBA16DCBF7067" modified="2015-04-29" version="1">MSSADDATTGVQRSKRPREDDDQEDQDHDGAHALALEPNGDAAAQRDGSETTASTTTTTTADAASNPSTDSAANGAAVQTETAGATRQRRKRAAWDQSSDAAVNPSGVSGPNGTSASLTAVASSNHSASAQNASSSHHLPLAEADLSADQAEALERARQFAQQLTVQFHAAQQQHLLRQQQLQQEQAAKMKQHAEAQQVALRTRAITLIGRVYVGSIPFEAGEREVRAAMSECGPIRSVSFVNDPVAPTRHKGFGFVEYEYPESGDIVLSQMHHARIGDRQLKFGTPNAPQPMQVLIEELRKEGSTFPHVFVANIHPELSESDIREVFQSFGPVAYCILMVDLVTGRHKGCGYVQFESLQTAKDAIAALNRLDLGGLLLHVVKGAHSPSNIQGLTTAQSAQVTNVLAGRTANDGELVFLAILLGCLFFLFVAVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWW5</accession>
    <name>A0A0D2WWW5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343447.1">
        <property type="nucleotide sequence ID" value="XM_004343397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWW5"/>
    <dbReference type="STRING" id="595528.A0A0D2WWW5"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWW5"/>
    <dbReference type="OMA" id="KMIILER"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="220"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="466" mass="52489" checksum="3655F241594E603C" modified="2015-04-29" version="1">MRQTQIKLARTLRFWLFLSSHKSEMKGFAIVAVAVVVLAVALQTVVLRPSLGQQARNALQTLKEPPPELAAPGWALQIAEAGLAVLDQLGVAVKPAPLRAFEALFGFGLTQGLAALARMEVFDGLAEAAENGTTCEELVVFMRKRDRDRRPIPIRRLPVDPELLCRLLDFAAANQFVNKDQDTGRFYLNEFSVLFTQGADNLASVAPMLFHNADEINLGWTRLHDGIRDKLSAFELANGDDVWSFYDKNPEKSANFNLAMRSISANFAPALLLGYADDFKEFVRQYKRPLHLCDVGGGIGSVAAGILSDFPNATATVIDMAHMETQANEYFEQVHLQDRIKFVPGNFFQPLAVECDYYLLKHIIHDWNDTSSLDILKAVRANMPSHSKLLLVETVMETRNPYFERLKRFVDMQMLVVFRDAKERTQHEFNALLEFSRFQMKRRIPLRGLFDIVEAIPVETSGNQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ2</accession>
    <name>A0A0D2WWZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270819.1">
        <property type="nucleotide sequence ID" value="XM_011272517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ2"/>
    <dbReference type="STRING" id="595528.A0A0D2WWZ2"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWZ2"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="580" mass="62431" checksum="1286A1756FEB989A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXK4</accession>
    <name>A0A0D2WXK4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342621.1">
        <property type="nucleotide sequence ID" value="XM_004342572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXK4"/>
    <dbReference type="FunCoup" id="A0A0D2WXK4">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXK4"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXK4"/>
    <dbReference type="OMA" id="NVCVREI"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="249" mass="26086" checksum="2F15B25F3EA04581" modified="2015-04-29" version="1">MASLNNLSVAGRVVLVSGASSGIGEATARLLAARGAKVVLGARRTDRIDAIVAEIKKAGGQAAGQKLDVTSLEDFEAFVRFAESTFGPVDVLINNAGIMPLAPLHALKVSEWTATIDVNIRGVLHGIAAVITKMRERKQGHIINVSSVAAHIVWPTGAVYCASKFAVAAISEGLRLENQDVRVTVVSPGVVESELAHTTTDENTKVALSKLREVALTPDAIARAIAYAIEQPADVAVNEIIVRPTAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXZ8</accession>
    <name>A0A0D2WXZ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXZ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXZ8"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXZ8"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254887" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="319"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="523"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1137" mass="118322" checksum="AB8CB50E89A1C85A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYM3</accession>
    <name>A0A0D2WYM3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYM3"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYM3"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="658" mass="70841" checksum="9958EA0A498DD84C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYT2</accession>
    <name>A0A0D2WYT2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase 75 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYT2"/>
    <dbReference type="STRING" id="595528.A0A0D2WYT2"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYT2"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000012">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="13">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE98218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="760" mass="81693" checksum="40FEE6AEB5BE5DEB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ26</accession>
    <name>A0A0D2WZ26_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346441">
        <property type="protein sequence ID" value="KJE98453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ26"/>
    <dbReference type="InParanoid" id="A0A0D2WZ26"/>
    <dbReference type="PhylomeDB" id="A0A0D2WZ26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="404" mass="42681" checksum="C80AD1AD71321220" modified="2015-04-29" version="1">MTTIYPNACLREVVLMLYNVPMHHSNEAIADMLNTKTGLKFEMCHRSIGKAPNGCPFETGTRIYYATLTSDVNVKQVIDKVPDSIQVTSASGFPRDVQIQVKGQPTKCFHCKQHHKYATCPTRRTQYNRHEANENETTRLNTHQAETANNDGFVQVGPKGKAAKAPTQRWPKPATAQPANQASTSKSNATMTTTQPAARTTQITATQPAAPRATAAASAAAAKANQTASSQAAPSTPQHSAQKRPASQLTPDGASRVHKQPHIQADEDTFAVDEATTTALAIAGADNDAAVELATLTFDDTSRDSIPSQQLNSDMQALVVATINLTTNDDVEATTNQPSVSTTAGATHDAFRDEGAHEAPNSENATTQKNVTDAEASALPSVSGPPATDAPGPSGADALSSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X051</accession>
    <name>A0A0D2X051_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269959.1">
        <property type="nucleotide sequence ID" value="XM_011271657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X051"/>
    <dbReference type="InParanoid" id="A0A0D2X051"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="16917" checksum="87F126B11D3EF43D" modified="2015-04-29" version="1" fragment="single">SSPFANLNFSRLQTPVAANQHQSRERINPDALRSRRRLNAFDSDNSASEFEHASAAEQHVAKRSRLASTSAGVNATTSSSTTEPVLTSSSSLAAQSLVNLDNGTDCNQTSSDSVARNASDDHEPDAVGRYCNPPIDEVKNRLGSLNVDLFLNTLDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F4</accession>
    <name>A0A0D2X0F4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F4"/>
    <dbReference type="InParanoid" id="A0A0D2X0F4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="387" mass="42570" checksum="5D03210CF1B805C6" modified="2015-04-29" version="1">MSVVTDPTSASTSAEASTGPAANTRQQTAARKEKIALLRAQLAALELENSELEGDSKNDEETPQQDEDLKDLTKTHQGQGGVIKTETDVEPQKLASSSSVPPPAVHQPAPRPQAVDWQPAKAPKLLAPSFDGTAAKLTQYEKDLKRYRSYFPEERWNEILSLTLVGSAADWFASGSDKWWRLSHQELCDRLRLRFGDPNERSTAKKAIRNMNKLSVLEIQTVLDKYAEVSGLSEGEIAGAIWDAMSLEVFQFARMENISENLPPSELMASLWAMQEWESRKVTAAPPQPQPQPSYKASFYGQRAAQPKQQPSQPQKQQTSVVAAVAFAEAMAAKYNLSAEELERRRREHLCFRCGSGTHLRKTCGQAPAVAAVQGEAAQGKAQPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K2</accession>
    <name>A0A0D2X0K2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K2"/>
    <dbReference type="InParanoid" id="A0A0D2X0K2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="12350" checksum="D8F9F3FBFCF46D1C" modified="2015-04-29" version="1">MDEQQLSQLSVVCEQAVVQGSSGALAQINEFFATDVLSKCELVLRSDGSGEYGHVVAATVLHDYLLEHDAILSIDIKIGIRKSTHHRFQTRDRGASRSSDSDHQARRQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X140</accession>
    <name>A0A0D2X140_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270096.1">
        <property type="nucleotide sequence ID" value="XM_011271794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X140"/>
    <dbReference type="SMR" id="A0A0D2X140"/>
    <dbReference type="STRING" id="595528.A0A0D2X140"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X140"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="106"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="413"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="681"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="94327" checksum="40323AE31F39C158" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q5</accession>
    <name>A0A0D2X1Q5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270199.1">
        <property type="nucleotide sequence ID" value="XM_011271897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q5"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Q5"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Q5"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="927" mass="102000" checksum="7EB551C7D141B506" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1T4</accession>
    <name>A0A0D2X1T4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1T4"/>
    <dbReference type="FunCoup" id="A0A0D2X1T4">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1T4"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1T4"/>
    <dbReference type="OMA" id="RYRCGRD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1T4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="166" mass="18403" checksum="04DB6E15499B573D" modified="2015-04-29" version="1">MSAIPPTAQTAYVAAGCFWGVQQLFAETPGVVDTAVGYMNGKTQNPTYKQVCYNETGHAEAVKIVFDPARVSYDALLKVFWDHHDPTTLNRQGPDHGTQYRSAIFYVDNAQKDAALASREAEQKQWSKPISTEVTAADVFYPAEDYHQHYFAKNGGGACHRVVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1W8</accession>
    <name>A0A0D2X1W8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349412.1">
        <property type="nucleotide sequence ID" value="XM_004349362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1W8"/>
    <dbReference type="STRING" id="595528.A0A0D2X1W8"/>
    <dbReference type="eggNOG" id="KOG1348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1W8"/>
    <dbReference type="OMA" id="ACGRYNS"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1W8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266746" description="legumain" evidence="10">
        <location>
            <begin position="19"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="11">
        <location>
            <begin position="353"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="49364" checksum="848F7C123456ADFC" modified="2015-04-29" version="1">MFKVVALALTLLVASAAARPHPHHHFPKFRDGADGNGTNWAVLVAGSNTYSNYRHQADVYHAYQILHKNGYPDSNIIVFHYDDIASSSQVSKQICIQPHSWRRHQPPERRNVYVNVPKDYTGDNVNPTTFLQVLRGIKPTVGSGKTLQSGPNDNVFINFVDHGATGLIAFPNDYLYANDLLSALSDMKNSKMYAQLVFYLEACESGSMFTSLPTNAFVFATTAANPDESSYATYWDDTYQTYLGDLYSVNWMENTDIAANLQSESLQDQFLAVQQLTNLSHVMEYGQLSLDALMIRQFLTFPNTEIEHHGFGHPAPASKKDSVSSRDVDLETHRRRLAAASTDDERRQAEMDLTAQQARREFITSTIHAVTARVAGVQAKDALVASRFAVNDFDCYKASVAAYERVCGRFGSFGMQYMYILANLCESGYTADQVSAAAQYVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1X1</accession>
    <name>A0A0D2X1X1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_002677</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1X1"/>
    <dbReference type="FunCoup" id="A0A0D2X1X1">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1X1"/>
    <dbReference type="InParanoid" id="A0A0D2X1X1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1X1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="202"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE91549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="513" mass="57236" checksum="D9BF134B81CE7F3D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X218</accession>
    <name>A0A0D2X218_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X218"/>
    <dbReference type="InParanoid" id="A0A0D2X218"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="226" mass="25315" checksum="DB3990280988C509" modified="2015-04-29" version="1">METSIEAEPAILLDLVIRRRVRLRLWFLRIRAGTPIHALWFLGGRVCWSQMRKKFCVANQTTRRELKLTLIRPCIRLHSIRTLRFTVPVSRHPRTRRRLECKSVMESRKWGKKVWVELATNFGGLPRSRLVCRENLFCLDPRRLSASGESRLCADDAGDGVVDDAGCLELVAADEAASWCSRALSMPMVLIGRSALSESGVEWVAGLAAVAAAFAAARRCSKLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2B0</accession>
    <name>A0A0D2X2B0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364087.1">
        <property type="nucleotide sequence ID" value="XM_004364030.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2B0"/>
    <dbReference type="FunCoup" id="A0A0D2X2B0">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2B0"/>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2B0"/>
    <dbReference type="OMA" id="CKQMTPA"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2B0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="7">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1167" mass="126263" checksum="D3763632A88E175F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2D3</accession>
    <name>A0A0D2X2D3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364182.1">
        <property type="nucleotide sequence ID" value="XM_004364125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2D3"/>
    <dbReference type="STRING" id="595528.A0A0D2X2D3"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2D3"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2D3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF8">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="173"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="380"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="79901" checksum="CEFABA019A4FD607" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X336</accession>
    <name>A0A0D2X336_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallochaperone Sco1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348211.1">
        <property type="nucleotide sequence ID" value="XM_004348161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X336"/>
    <dbReference type="FunCoup" id="A0A0D2X336">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X336"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X336"/>
    <dbReference type="OMA" id="DMCAKYK"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X336"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF25">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="123"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="161"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="36290" checksum="04721981327DFA35" modified="2015-04-29" version="1">MLSRLALSAVRLGRPSPLAVSSTSSLARRCFASSNEAPPKKSEPSEATSSSNKLSFEEEAARQIRNAELIRDTRGKNEEFNKGPVTWVSLGLLAVAGAGLVMYFQSERANHRANLEAKRNRGLGVPKIGGPFTLVDTNGKRWTEEDLKGRWTLIYFGFTFCPDVCPDELDKMTEIVNTIDNTPDIGPVVTPLFISVDPMRDNAKIMGEYLAANAFHPRIVGLTGTTEEVHQVARAYRVYFSAGMPENPADDYLVDHTIIQYFMNPEGKFATYYGQTTTAQDAAKRLIQSIREYRADAPERERASLMAELDAAKAAASNPTAQGATPPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4G9</accession>
    <name>A0A0D2X4G9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345162.1">
        <property type="nucleotide sequence ID" value="XM_004345112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4G9"/>
    <dbReference type="InParanoid" id="A0A0D2X4G9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255496" evidence="2">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="271" mass="29237" checksum="65F355D7E492A579" modified="2015-04-29" version="1">MSPLPDAAALPFVILAKLVMSQPPPSTPSSMSSQASMPAPVTHSMRVIRRVVRLPNSAALASLSSQLRSWSMAGETSDAETISRSDRPIILQLTVLTVTKRSTSLAASSISSMHPASDMQDQRRRVRARRARLIPASLPPPPTTPLLPPAYVPVVPSHTNYLVSSLGDGKPALSPMHDVCTSDLTGDSCQRWSAILGRNNRLQRELEDPRMLLNDASWNLEAAQRCFGEVPVSRPIHQCRSVTGLTSTTTLPESTKPAENASPDRLKGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4S0</accession>
    <name>A0A0D2X4S0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4S0"/>
    <dbReference type="InParanoid" id="A0A0D2X4S0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="26694" checksum="76023AED817FD35F" modified="2015-04-29" version="1">MAAGSSREHWQIAGSYWLRFRASRSRSADGCCPSARQSWTACPVVAEHPSQHRQSQTRHGRRREAAAAAAGGRDSGQRTDSPRFRRWSGACDCCAWPCAPAAVVVVVDLRPLHSERRQQQQRGRPACSTSTRPACLRAGSNRRRRRHPHPHGRCSAASPPPPPPPQCLVMQTTTATQRASRPEWPSDLRHSARSQQQLRFHFHAGQYLRRRRRWLENRSRRHCSRASSSHPAVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5E5</accession>
    <name>A0A0D2X5E5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342849.1">
        <property type="nucleotide sequence ID" value="XM_004342800.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5E5"/>
    <dbReference type="eggNOG" id="ENOG502STK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5E5"/>
    <dbReference type="OrthoDB" id="10616678at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266830" evidence="1">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="22763" checksum="29FB538394EF121D" modified="2015-04-29" version="1">MKHLSASLAVVAFCVIVSLATSIYAVPIAIAQKPDSAAMAERDYHRVGLAAKLARLNNNNHKKIQLPAARVGNESDWSSCIDIPVLGETCLVLYVIPENLTLGAKLTIDNHTVLDEELDGNHICLSDTSLLSLLELIPALIPFKAIIDAIIKADKYIPAHILSICLNLTNVVFNSTSVSGCADLDSNIMCFESKCLYSGDDSFGCFNIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5F6</accession>
    <name>A0A0D2X5F6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fer1l3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342902.2">
        <property type="nucleotide sequence ID" value="XM_004342853.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5F6"/>
    <dbReference type="eggNOG" id="KOG1326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5F6"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5F6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2152"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="208"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="363"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1152"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1665"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1903"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2185" mass="245707" checksum="C2F83564DF97D72F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9CB93</accession>
    <name>E9CB93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_005294</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346979.2">
        <property type="nucleotide sequence ID" value="XM_004346929.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270492.1">
        <property type="nucleotide sequence ID" value="XM_011272190.1"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CB93"/>
    <dbReference type="PhylomeDB" id="E9CB93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Roc" evidence="18">
        <location>
            <begin position="397"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1385"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1040"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1441" mass="157536" checksum="5EB2D7FDBDC6E16A" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZR1</accession>
    <name>A0A0D2TZR1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364950.2">
        <property type="nucleotide sequence ID" value="XM_004364893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZR1"/>
    <dbReference type="STRING" id="595528.A0A0D2TZR1"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZR1"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZR1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="450" mass="49397" checksum="531183F9C076BDB1" modified="2015-04-29" version="1">MLTKGIKAIYTNHRVFSAAGQLMFLCDDRKLNWYLKRSLAVELNPNVAEGDEAAAARPLQPAALESSPAALLNATAAGAAAAGTAGPRAIRLTFTPKGLGRVNDPFYLQALPNRCFVCGAFDRHVARAVREAETPAASQSGLASGDNSDPPPATIYRCHVVPSLYRRHFPRIYKSHAAHDVLRLCGACIRRLDPVRAAVMKQLAKEFGVPVDTSPPLTEYEQRVERIARLGSALNGHSHNMPPARVELLTTELLGHVAFTQLAATKEGDADLLPSWWSTSSEVLEHLQQVVDVANSILSKSKSARKVRLRDGRREHPEDARERLGRKAAREKELADSTVSDASRPNLSKGEGAPHSGRLDGDSGKDNGAIRANDDDDDDDDDDNNNDNDDEDDDDDDDDEADHGRLVVARLSTDAALLDFVRRWRRAFVQSLRPQHLPAHWSIDRSLDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U463</accession>
    <name>A0A0D2U463_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349879.2">
        <property type="nucleotide sequence ID" value="XM_004349829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U463"/>
    <dbReference type="STRING" id="595528.A0A0D2U463"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U463"/>
    <dbReference type="OrthoDB" id="9044749at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U463"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17682">
        <property type="entry name" value="RUN_RUFY4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="156"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="339"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46714" checksum="0933CB13CB703E4C" modified="2015-04-29" version="1">MDPVVADLLSDRWGAVHHHLQVTSAASASSDGAPSADDGAHAVAATSLITRPAAYEPEPDPCRDLLMALKDAVDELEHYSKSGSTTADKSLLIRTVEPKQLPWVGTPSKPKTEERRTSLVATEEGDWTSPMLLSANDSTTLAEVSEEPGSETRFISDEHHLLETFCSSLEACLRLGLKSTVMFSSVKYDYWDWITELVAPHTPLPNESSSPAADNISITLWPSSNSKPKEIPTINPIMNGIVSTISSRTPSLQTPQGRGRQFIRMALTSKVLTVPLQQLSRNKKLREAWYSKEDSILGHPKHIQELIATLYEITAIDFQLDLSNTTSLDDTWTLPIMRHVTFIKSPEFGLGIDILQSGEHITIVGVKPGSPAANSNAIDVGDILENVNGLVVANQPQSVVTQHIRAIVGRVDLVIRKSSSKHNEVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U643</accession>
    <name>A0A0D2U643_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364754.1">
        <property type="nucleotide sequence ID" value="XM_004364697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U643"/>
    <dbReference type="FunCoup" id="A0A0D2U643">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U643"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U643"/>
    <dbReference type="OMA" id="DFRRCHA"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U643"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="304" mass="34835" checksum="046BC7249FDD9A4E" modified="2015-04-29" version="1">MAFKPRTQEFLSLRLHAREHQRTHDISPHGYEDDNAKLLGQRGGHVKLSMVPEAAPEWIDHVDSIKLRMRDIAANIQDLIKKHEEQMRRTDFDDDNNDDEHAIDILTKNISSGFFECQRDIKMIAERAKQTGHPDEIKMSRNVVSALALELQKMSTDFRKSQNQYLQRLRARDKGILFQPGEVPQDTLADEEYHVDSGFTAEQLQATQAAIEFSHQREAEIELLVQSISELAQIFKDLSEMIYDQGTILDRIDHNLDVTLQCIDEAEKQLIDANKYHKKATKKIIILCLVVIVLALVIAVASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U970</accession>
    <name>A0A0D2U970_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349461.1">
        <property type="nucleotide sequence ID" value="XM_004349411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U970"/>
    <dbReference type="STRING" id="595528.A0A0D2U970"/>
    <dbReference type="eggNOG" id="KOG3027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U970"/>
    <dbReference type="OMA" id="YFQTRCL"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U970"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03054">
        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="238" mass="26023" checksum="0F3575B7BF059AAD" modified="2015-04-29" version="1">MADDDPIVLYQHPPGWGLASRDAACLAVQTALKLARLPFTVNNAGNTAVSPTGELPLLCAGEELFSGFGPCLAYIRNRDTSDVFNALTDEEGASAKAFMSLVQVELQYAKIYWYWFEEDNYTAVTHPRFASRFAWPLNIFLAWRQQRDYHALLSTKFEQVSAEKIYAAASTALDALSARLGDSDWFFASPSALDCCVAAYVSEILGAGSELPTPALATIVRGHPTLVAHAQRVLAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCM5</accession>
    <name>A0A0D2UCM5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363424.1">
        <property type="nucleotide sequence ID" value="XM_004363367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCM5"/>
    <dbReference type="STRING" id="595528.A0A0D2UCM5"/>
    <dbReference type="eggNOG" id="ENOG502QTG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCM5"/>
    <dbReference type="OMA" id="MENTHCT"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04332">
        <property type="entry name" value="YbaK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411:SF4">
        <property type="entry name" value="YBAK_AMINOACYL-TRNA SYNTHETASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29050" checksum="A2E6BD913CAD7E49" modified="2015-04-29" version="1">MDSTEARQATLLAQLEQLSTSITLLYSGILDEASVPVKFNVNRALVLSQGQTSESKDAAQPKVGEPEAVQRVRRACESAALHMSLRCVPSDYYDWTLERRRNVLQAPSIHHLCKSIVLENTRMNKAANKADLTGIGAAELAASASLDPRNSKYYCVIVQYTTKFDSDKMVSYIRNLHKPVLSTKTLNYRLVDPEVSFALTGFDKNGVCPIGMTRNVPILVSRAILSLQPPVMYLGAGDIDWKLVVSVDDFLRTTGAQTADLITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCQ0</accession>
    <name>A0A0D2UCQ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2UCQ0"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCQ0"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCQ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="23063" checksum="108264B25AA388B5" modified="2015-04-29" version="1">MTEQLALGRLKFDPYLVLGVPRHASNKDIKRAFYALSRKLHPDVVPAAARAAAHSRFVVVSQAYTILSSPTLRLQYDRLRGLHEFQPSSSSSFHEGSRGFSGASQSSAPNPGETWQQDAETFKRQAAGQLTAHRRWMTNGRLILSLGALVVGATALQFALAGRQQARRTEYMDARDVRRRRHRHRSCPPPVAAAVVVLLIVGSLITPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCU2</accession>
    <name>A0A0D2UCU2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363494.1">
        <property type="nucleotide sequence ID" value="XM_004363437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCU2"/>
    <dbReference type="STRING" id="595528.A0A0D2UCU2"/>
    <dbReference type="InParanoid" id="A0A0D2UCU2"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="23322" checksum="3E89C3DADEE5495E" modified="2015-04-29" version="1">MSSSSELVQDQATNAEINSEMQKRIAQKRAEIDENNQREFTAPARPGDATCARVGAADIQRHRNLDTGALSSSHVPAVRMDNVVGTYLLPHGVEERVASLEAHLGMENRKLPLNFMARIKEIEDRILALERIDPDYFIARVAVAKQITAHPNLASFASREAAEAASATSATTKRPADETLDSTDSIESRIKELTQTLRDKKQKRTKVDSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGI9</accession>
    <name>A0A0D2UGI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347618.2">
        <property type="nucleotide sequence ID" value="XM_004347568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGI9"/>
    <dbReference type="STRING" id="595528.A0A0D2UGI9"/>
    <dbReference type="eggNOG" id="KOG3695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGI9"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="820"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110870" checksum="BD3685E656446A41" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHE1</accession>
    <name>A0A0D2UHE1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346844.1">
        <property type="nucleotide sequence ID" value="XM_004346794.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHE1"/>
    <dbReference type="FunCoup" id="A0A0D2UHE1">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHE1"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHE1"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14385" checksum="F4CE86C1A1773CD9" modified="2015-04-29" version="1">MSISALQQQFESHVDELRKLQQSYSKLVDSRTQFETQLNENKLVQEELRLVDSEGSVYKLVGPALVKQDLPEAKSHVDKRIGFITTELDRLDKAMKEYDEKMNTLRGTVMKLQNQLMQQQASAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHU5</accession>
    <name>A0A0D2UHU5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346964.2">
        <property type="nucleotide sequence ID" value="XM_004346914.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHU5"/>
    <dbReference type="FunCoup" id="A0A0D2UHU5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHU5"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHU5"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHU5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="315" mass="33898" checksum="F7A456A934BB7028" modified="2015-04-29" version="1">MSNNLSDVVVPYGTKLTAATNGKVEGSATVKTGLAQMFKGGVIMDVINVEQARIAEEAGACAVMALERVPADIRKHGGVARMSDPHMIKEIKAAVTIPVMAKCRIGHFVEAQILTECGIDYIDESEVLTPADDKHHILKSEFPIPFVCGARNLGEALRRINEGASMIRTKGEAGTGNVIEAVRHSRQINAEIKQVQNMDEVELFTFAKEIQAPFHLIKQVKELGRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFKSGDPAKRARAIVQATTHFRNAKILAEVSENLGEPMVGINIDTLPEGEQYAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJE3</accession>
    <name>A0A0D2UJE3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346352.1">
        <property type="nucleotide sequence ID" value="XM_004346302.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJE3"/>
    <dbReference type="STRING" id="595528.A0A0D2UJE3"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJE3"/>
    <dbReference type="OMA" id="IQQPMSK"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJE3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000176">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="26621" checksum="CD257C16BACD222B" modified="2015-04-29" version="1">MSAGLSLYFDAMSQPSRAVLILLRANNLPFTPKIINVVKGDQYKPEFKKINPNKKIPVIDDNGFVLFESHAILRYLCNKYNLPDHWYPKDPQKRALVDQYLDWHHTYTRTAAHHFREKYMAPRFGIQIDEKSSAESFKTFQFALKQLDTNFLQSNRFIIGGDKPSIADISAVCELIQLQMVRFDFSPFANVDKWMKDVAASVPAFDEVHKIFYSVRDRELAGLSTAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UN54</accession>
    <name>A0A0D2UN54_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344403.2">
        <property type="nucleotide sequence ID" value="XM_004344353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UN54"/>
    <dbReference type="STRING" id="595528.A0A0D2UN54"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UN54"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UN54"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002461">
        <property type="entry name" value="Zinc finger matrin-type protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="218" mass="24370" checksum="FF95D33B9527E255" modified="2015-04-29" version="1">MSSSNKPPSQVNDLDLAFRRTWDRAEYEQRMKDRQKSEEDRRWDSDDSDDDKPKALLKGREYKIDLTSKLGKSVVLTDKDAITGAGYYCKTCDCTLKDSLTYMDHINGRKHQRNLGMSMKVERSSNDQVKARLAALAKRKNEDYDDSRPKTGQVGAHVDKKGRQDDDKQDSKPASKPKAAAAAAAAAPPSQPEEEEDSGMDPELARMMGFSGFGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF48</accession>
    <name>A0A0D2VF48_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF48"/>
    <dbReference type="STRING" id="595528.A0A0D2VF48"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VF48"/>
    <dbReference type="OrthoDB" id="5988891at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VF48"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF465">
        <property type="entry name" value="GPS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="405"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="571"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="969"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="123921" checksum="8B3B8DB12EAA31EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFE1</accession>
    <name>A0A0D2VFE1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Propionate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFE1"/>
    <dbReference type="STRING" id="595528.A0A0D2VFE1"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFE1"/>
    <dbReference type="OMA" id="FIMGRTD"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="5">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="608"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="733" mass="79994" checksum="FF4642BF074AD03F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH55</accession>
    <name>A0A0D2VH55_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365648.2">
        <property type="nucleotide sequence ID" value="XM_004365591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH55"/>
    <dbReference type="FunCoup" id="A0A0D2VH55">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VH55"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH55"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH55"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="61865" checksum="7E52A1E354D37856" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIE2</accession>
    <name>A0A0D2VIE2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366037.1">
        <property type="nucleotide sequence ID" value="XM_004365980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIE2"/>
    <dbReference type="InParanoid" id="A0A0D2VIE2"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="56251" checksum="8C644E340F08A088" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIW6</accession>
    <name>A0A0D2VIW6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349852.1">
        <property type="nucleotide sequence ID" value="XM_004349802.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIW6"/>
    <dbReference type="STRING" id="595528.A0A0D2VIW6"/>
    <dbReference type="eggNOG" id="KOG3491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIW6"/>
    <dbReference type="OMA" id="KSNDAFH"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="65" mass="7055" checksum="5B7EAF7FFE08DEA2" modified="2015-04-29" version="1">MAGSARMKKSNDAFHGNVNKRGIVKPTTRQDDKYPVGPAVLALFIFVVCGSAIFQIFQTVRSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ17</accession>
    <name>A0A0D2VJ17_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349892.2">
        <property type="nucleotide sequence ID" value="XM_004349842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ17"/>
    <dbReference type="STRING" id="595528.A0A0D2VJ17"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJ17"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJ17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000008">
        <property type="entry name" value="GAF domain-containing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="171" mass="18379" checksum="A24986A8F5B88ECE" modified="2015-04-29" version="1">MTAADKASFYENLIAEAKAVIDGEHDAIANLSNVSSLVAHALNGSSLHGKKTYNWVGFYLMRKGELVLGPFQGKVACIRIKPGRGVCGASVVRKAAVLVPNVHHFADHIACDSASNSNSELVLPLFSPTGDVIGVFDLDCEQEDGFTEEDQAGLEPIVRALEKECDWSSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJL7</accession>
    <name>A0A0D2VJL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364381.1">
        <property type="nucleotide sequence ID" value="XM_004364324.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJL7"/>
    <dbReference type="InParanoid" id="A0A0D2VJL7"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1248" mass="132129" checksum="1A9C1793FEFC605B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLK4</accession>
    <name>A0A0D2VLK4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348961.2">
        <property type="nucleotide sequence ID" value="XM_004348911.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLK4"/>
    <dbReference type="STRING" id="595528.A0A0D2VLK4"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLK4"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1255" mass="136453" checksum="F3797828F581E0C3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLV9</accession>
    <name>A0A0D2VLV9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLV9"/>
    <dbReference type="STRING" id="595528.A0A0D2VLV9"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLV9"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLV9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000732">
        <property type="entry name" value="GD11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253697" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="35"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="65230" checksum="CC45252E99126A5B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMF2</accession>
    <name>A0A0D2VMF2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein rpl14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349239.1">
        <property type="nucleotide sequence ID" value="XM_004349189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMF2"/>
    <dbReference type="FunCoup" id="A0A0D2VMF2">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMF2"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMF2"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="5">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="16670" checksum="E853DB9837089A90" modified="2015-04-29" version="1">MVYTRFVQVGRVALATDGPAKGKLVVIVDIIDQTRALVDNPAQGVDRQSLSFSAMQLTDFTVGIPHGVGSAPLRRAYAKAEVETKWNQTNWAKTIARRATRASLTDFDRFKVMVGRKERSKIVSTAFNKLRRPVSAANKAKKAGSKKAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMG6</accession>
    <name>A0A0D2VMG6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 6"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349251.1">
        <property type="nucleotide sequence ID" value="XM_004349201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMG6"/>
    <dbReference type="STRING" id="595528.A0A0D2VMG6"/>
    <dbReference type="eggNOG" id="KOG4749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMG6"/>
    <dbReference type="OMA" id="HRQHCIV"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMG6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="456" mass="50832" checksum="36408E73E33F0670" modified="2015-04-29" version="1">MQALRAEDWSYRGEGAANIVVSFTGDQASNPELEGKVLRIRKSPVVAPSEPRQTFSTEQNYAYLTRLIAPLLGDEYVNAGQLVPLAATFLQDLDQRIAAERPAKRVQAARLDCAGSAAQLLRDVGRPFIQSHDQSDTFCVEIKPKWGFLPTSSFIHPSNATAKLSKCRYCMHQWLKVSNGSIDRRSRYCPLDLFSGTRHRVERALHSLVDVPQNNVRVFRNGRAILTGDKAPPADSNSRAYIAELDRHLVDLVPAAADDSDAQPPHVQTFVSLLAEILLQEPLLQRLQAAQRLDHLDIEGLKGLYDSVIERHPVGQDHWLWDGRFDAPEWSRVVQQALARSSTAPSLSVHDVAALSLDEKAAIIAEYLLAATVKDCSIMVSVQRLSTPSEDPATHFKHITHSGTRFRYHVAVVDLDPKLFRNIPKYHRDDGEIVQHYMDHADDSTCYCSGPAQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNC1</accession>
    <name>A0A0D2VNC1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363720.1">
        <property type="nucleotide sequence ID" value="XM_004363663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNC1"/>
    <dbReference type="FunCoup" id="A0A0D2VNC1">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNC1"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNC1"/>
    <dbReference type="OMA" id="NWAVGIP"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNC1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="134"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="35800" checksum="6769E958420E8B74" modified="2015-04-29" version="1">MVDWAQLEKEAASHGLLWNFAYKVARPAKPRDGPPSSLKNLLAGSFGGICLVAAGHPLDTIKVRLQTQTVVAGQAPMYTGGLDCFRKIVAREGFSGLYRGMLAPLLGVTPMYAICFVGYDIGQRIQRKTPTERLSLLQLFNAGCISGVFTTAVMVPGERVKCILQIQGAQVSQGIAPKYSGPKDVFVKVYAESGIRGIYKGTVATLLRDVPGSGAYFGAYEYLKRTLSKDGSGQNLRMHEALFAGGMAGIANWCVSIPADVLKSRLQTAPDGTYPNGLRDVFRTLVRNEGYLALYKGIGPVMLRAFPANAAMFGGYEFMLNQLYEFFPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP77</accession>
    <name>A0A0D2VP77_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; alpha-glycerophosphate cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364069.2">
        <property type="nucleotide sequence ID" value="XM_004364012.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP77"/>
    <dbReference type="FunCoup" id="A0A0D2VP77">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VP77"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP77"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP77"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000088">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="11">
        <location>
            <begin position="144"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="12">
        <location>
            <begin position="332"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="480" mass="51269" checksum="92422534280A2DC9" modified="2015-04-29" version="1">MTHCDQSAATPRTNLSALLGLDAATTSAPSSFFATASASSGVDAASRRLNALFPMTSLLSSAPCASSSSSSSSKPPQQVLRSASANTSSAPAASSTSHSNSSNISSSSNGSSKSQRSPTAQKSNSRRRGSLKHTQSLPHKMPYKICIIGSGNWGSAIAKIIGNNVQAHSGVFDQHVTMYVYEEVVNGRKLTEIINTEHENVKYLPGIKLPSNVVAVPDVVEAAKDANILVFVVPHQFVINICKSLHGKIAHDAKAISLIKGIDTTNGIQLISDVIRDELNIEVGVLMGANIAGEVAAENFCETTVGCANVRMGGIYKQLFNTSYFRVNVVTDTIAVELCGALKNIVGVAAGLADGLKLGDNSKAAIIRIGLCEMMKFARLFYNCNDFMVYFESCGVADLITTCAGGRNRKVAEAYVQTRKPFQQLEAELLNGQKLQGTLTAKEVYHVLSEKKLTQEFPLFTAVYQVCFENLDPQLFLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTC8</accession>
    <name>A0A0D2VTC8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTC8"/>
    <dbReference type="FunCoup" id="A0A0D2VTC8">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTC8"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTC8"/>
    <dbReference type="OMA" id="QTGGMII"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTC8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="166" mass="18726" checksum="8621694D99A55A07" modified="2015-04-29" version="1">MRSQPSILITGTPGVGKTTLCELVSAATGYPHYNVSQMAKDGNMLDGWDEEYQTHLLDELEPLVHPGGAIVDYHGCELFPKRWFDLVVVLCADNTVLYDRLSARGYTGKKLSDNVESEIMQVILQEAHESYDAEIILHLENDTTEQMEQNVQTISEWIAQYKLKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTZ9</accession>
    <name>A0A0D2VTZ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346073.1">
        <property type="nucleotide sequence ID" value="XM_004346023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTZ9"/>
    <dbReference type="STRING" id="595528.A0A0D2VTZ9"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTZ9"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269539" evidence="4">
        <location>
            <begin position="32"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="479" mass="53577" checksum="D4B1CEA25D813E86" modified="2015-04-29" version="1">MAIQQGRLRLRLGLLPVLALVLLLATTAATADDSDNQVNPLAAIDVWLGRLGGRLDTSLVELRSDGDRGRGLVAKQAIPPKTVFARIPLTALINIEHAMVSDLGPVIDASDLSDQEIMSVFLWHQLHGCGQVEDGGVAESNWQPFLDTLPDRQEMHLTMLWTPEQLAHLDGSLLRDFSERRIQVLEASFKRHQQSTFGKFPSAESCDWTKFTLEDFLWGMAIGWSRTHAVRVRDGEGAWQTANCLVPVADLLNTDIASKVNAECYTNDESTHFECRTRHQLAQSEELLAQYNADSASIDNHHLLMDYGFVLNDDSARRAATIGRPIPLDDPDRAKRLSVLKQHKMQMGMSLPLSFTDFELPLTYYRILCARSQVLNSKWTPSFKPTILPEEETCARDHLRVAMLEQLGRFPTKQASEPIALAQIQAAFAENCKTNPTNAKCISLHRQALAIQLRISERGLLSDLVQRLTQKETPSKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU02</accession>
    <name>A0A0D2VU02_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346077.1">
        <property type="nucleotide sequence ID" value="XM_004346027.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU02"/>
    <dbReference type="STRING" id="595528.A0A0D2VU02"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VU02"/>
    <dbReference type="OMA" id="HSNHGDV"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU02"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000367">
        <property type="entry name" value="ABC transporter G family member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253894" evidence="10">
        <location>
            <begin position="28"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="939"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="319"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="966" mass="104813" checksum="58C37BA94B6C6777" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUW6</accession>
    <name>A0A0D2VUW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346333.2">
        <property type="nucleotide sequence ID" value="XM_004346283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUW6"/>
    <dbReference type="FunCoup" id="A0A0D2VUW6">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VUW6"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUW6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="138"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="472" mass="53620" checksum="CF212E98D648A909" modified="2015-04-29" version="1">MSSFMKGILIVKLVEARGLTKRGRDPGRPYCVVGYDGTEVLTHDADGVGDGCVWNQAFTFDVCQANAELNIAVWDRAGSAGNEFLGTFKIRPTRIPNKVNDTWFKLIPKDWKERTKGEIHLALCYRLVDAKPVTIDDFDLLKVLGKGSFGKVMQVRKKDTGRIYAMKILVKDTLVARDEVQHTKAERHVLAQCDNPFLVSLKYCFQTPEKIYMVLDYVHGGELFLHLQKVTTFSDERAKFYTAELVVALEHLHAHNIIYRDLKPENVLLDYSGHIVLTDFGLCKENMEYDTQTKTFCGTAEYLAPEVLKGQGYSRSVDWWSLGVLLYEMLTGLPPFYSENTNLMYKKILYSDINFPPNAVSEVGQDILRGFLKRNPEERLGAGPDDAVPIKAHPFFAEIDFDMLVSKKLLPPFKPHLKNLEDVSNFDPEFTVETPKDSFVDPTTLSSTLQNEFRGFSYVDYDENALHQASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV35</accession>
    <name>A0A0D2VV35_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346433.1">
        <property type="nucleotide sequence ID" value="XM_004346383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV35"/>
    <dbReference type="FunCoup" id="A0A0D2VV35">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VV35"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV35"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV35"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="212" mass="24850" checksum="526C8566993854A5" modified="2015-04-29" version="1">MNIFRLAGDLSHVVAIFLLLWKIWTTRSCKGISLRSQGLFALVFTLRYLDLFTTYISLYNTVMKILFITSSYGTCYLIFKKFRATYDHNVDNFPLQYPLGACVILALIFNHSWDPVELLWTVSIYLESVAIMPQLWMIQKTGEAESVTSHYLFALGAYRALYLLNWVYRYFEEDHFDAIVVFAGIIQTVLYCDFFYLYITKVLRGQRLKMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW44</accession>
    <name>A0A0D2VW44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345744.2">
        <property type="nucleotide sequence ID" value="XM_004345694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW44"/>
    <dbReference type="STRING" id="595528.A0A0D2VW44"/>
    <dbReference type="eggNOG" id="ENOG502QSJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VW44"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="791"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="860"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="928" mass="97606" checksum="608C0F751A703B1E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWK4</accession>
    <name>A0A0D2VWK4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345094.1">
        <property type="nucleotide sequence ID" value="XM_004345044.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWK4"/>
    <dbReference type="STRING" id="595528.A0A0D2VWK4"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWK4"/>
    <dbReference type="OMA" id="HIDNQCT"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="210" mass="23433" checksum="C62C868671A6A9CD" modified="2015-04-29" version="1">MNVALYSTPRFGALKHTIQSEEQRNSSSGDDVAQPPSSPSNNSSHQHEDAQDLLSFGTHCDVKDCRQLDFLPFRCDSCTQTFCLDHRTYESHKCSAAPNQDIRIPECPKCQQKIQRPRGSDAAAQIQKHIASGCRDLVLLAPRRKCNHKGCKNTEALSFKCNRCEHQFCIKHMRVQDHTCSSQSIPPSGSDAHRLAKPGQSALKRAITAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX50</accession>
    <name>A0A0D2VX50_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosome maturation protein SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345287.1">
        <property type="nucleotide sequence ID" value="XM_004345237.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX50"/>
    <dbReference type="FunCoup" id="A0A0D2VX50">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX50"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX50"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX50"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="250" mass="28354" checksum="5DAED151F410AC8C" modified="2015-04-29" version="1">MSIFTPTNQIRLTNVAIVRLRKGGTRYELACYKNKVMSWRSGVEKDIDEVLQTHTIFLNVSKGQAAKREEIEAAFGTADQEKVIHEILTKGELQVSEKERQVQLDAMYREIATIVTEMCVNSETQRPFTVTLIERAMKDAHFSVNVTKSTKQQALEVIKQLQETISIKRAQMRVRIVLPVKDAKKIKDRVVSLVSTVESEEWTGDLELTCLIDPGAFRPLDDVIRSETKGQGVLEVLSLKHIEEGDELIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY44</accession>
    <name>A0A0D2VY44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metal-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344514.1">
        <property type="nucleotide sequence ID" value="XM_004344464.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY44"/>
    <dbReference type="InParanoid" id="A0A0D2VY44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269611" description="Metal-dependent hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30055" checksum="4B02D6EBD69E7A89" modified="2015-04-29" version="1">MQAGVHLLAGLLMCLLFPRHKSIGAAAGDARLGCVLGAILPDADIPVTVLMVALSGNYEVADIYHRTVTHSIVFALLCFAIMTIFADLVRAHIQKDKLWFIARTHPVRRHVFEPQAFGTGLVLGLISHAVLDMMYLKGVAIWWPFSDARVGYPLFGYWTTQTELTVKLLEASDHYTDVLFFFIPVMVVANWHQIHTAQWNQIVGYCVAKCAVTTAFIILAFIPAVSFETFFTLLYIPGTFFFTISVIAPLLFRDAVRRFGDPTVPQRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY48</accession>
    <name>A0A0D2VY48_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270701.1">
        <property type="nucleotide sequence ID" value="XM_011272399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY48"/>
    <dbReference type="STRING" id="595528.A0A0D2VY48"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VY48"/>
    <dbReference type="OMA" id="FRAEWIL"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY48"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10001">
        <property type="entry name" value="HDAC_classII_APAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="365" mass="40302" checksum="C7B6A480DB6A0FE7" modified="2015-04-29" version="1">MSFVCVYDETNAQHAPPVEFYAATGWEKHVEKPIRTEKILTSLKATFGDRLALVAPRSEHYGKEHLLAVHDAAYLEWLEVAWSNYAEFRKLRFNDDKTVEHGLIPDVFTFGPRHQLPKCKSLHAGHYCFDTYTPIMPATYDAAVRCGAHVALTGADLLNEQNNARTAGEAAPTVYALCRPPGHHAGADYYGGYCYLNNAAIAVAHLKTLGHARISILDIDYHHGNGTQDIFFHDPAVQYVSIHGDPDAEFPYYSGYASEVGEHNQALNLPLPLFSGEVPYQEALKKAVKAISAFGPTILVVSLGVDTQLNDPMGTFKLVAPMYKAVGETVRAELVNLPTLVIQEGGYRLETMGDCVAQFMAAFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYM0</accession>
    <name>A0A0D2VYM0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343818.1">
        <property type="nucleotide sequence ID" value="XM_004343768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYM0"/>
    <dbReference type="STRING" id="595528.A0A0D2VYM0"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYM0"/>
    <dbReference type="OMA" id="KKDFAFQ"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="353" mass="37126" checksum="B9FC82E72D909946" modified="2015-04-29" version="1">MAQASKTVKAFAALQAGQTVSHWEFPAPELTPHMIAVDVTHCGICHSDIHMMGDEWRGDTGGSPTTFPLVPGHEVIGTVSALGSAVTGFKVGQRVGFGAQGSSCHECALCAKGHEHNCTKFGGLYDPNHGGYAAHIRADSRFCFAIPDEIPSAHVAPLMCAGVTVFTPLATHLLPPGSRVGIVGIGGLGHLALQFANKMGYHVTAISTSPSKEAEARSLGAHAFLNSSDAAQMKAHGNAFPLIIYTASGNIDWNAYMGLVAPEGKFVVCGLPEAKIQVSPMYLIGGSKTIVGSLVGGTKAIKEMLAFSALHGVRPMIEEVEVGHGADADKVNAALTRVRENKARYRCVMKYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHH0</accession>
    <name>A0A0D2WHH0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270001.1">
        <property type="nucleotide sequence ID" value="XM_011271699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHH0"/>
    <dbReference type="STRING" id="595528.A0A0D2WHH0"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHH0"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="181"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="558" mass="60029" checksum="F01C334C50A2B707" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIA1</accession>
    <name>A0A0D2WIA1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365146.2">
        <property type="nucleotide sequence ID" value="XM_004365089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIA1"/>
    <dbReference type="FunCoup" id="A0A0D2WIA1">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIA1"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIA1"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="759" mass="82525" checksum="4F4CC8F3C95545FC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIS0</accession>
    <name>A0A0D2WIS0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transforming growth factor beta regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIS0"/>
    <dbReference type="STRING" id="595528.A0A0D2WIS0"/>
    <dbReference type="eggNOG" id="KOG4443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIS0"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="645"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="811" mass="85426" checksum="0DAD89C533219AC1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ52</accession>
    <name>A0A0D2WJ52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ52"/>
    <dbReference type="InParanoid" id="A0A0D2WJ52"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ52"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="49437" checksum="6AEF6FC6AF110CBE" modified="2015-04-29" version="1">MSLPEAALKSGVLQLVVLVHGLDSPLGGHRDMRLLESRVLVHPGFRDFKVFVSTVNSGKTTDSIHVAGIRLADELERFVHALPEVIKTVRPPSADCSLGMRTEQAPTRTAIKLSNAASLKTQLHALLRRYAIGWLYERNYFQSGRMVPVAYMSMASPHIGISYDRDNCETREEDNRRIFTNVARWVFYESKQRVAKLFWRGQCVTELYLQDEGAAGSGSFKPLLYELAVPTSRYMLALGLFKSRTLVSNTHFDFQVDYLSSAIACDYPFDTPGDVVGMDLGETCQRPSDSYEGLKHPSIGLVAKTVGLVKQVADIARFPFDWFNYSADEDHDIFSVTYTGFSSVPKSLCNISARAYSEPQEKKITTPAISRSIGRLRAEITRNLQTLSWRRIDTRFNSLWCHDYFLGKSTVHFSVVSDPKPARPVLDMFLNVLAEDANQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJG7</accession>
    <name>A0A0D2WJG7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365836.1">
        <property type="nucleotide sequence ID" value="XM_004365779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJG7"/>
    <dbReference type="STRING" id="595528.A0A0D2WJG7"/>
    <dbReference type="eggNOG" id="ENOG502QU1X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJG7"/>
    <dbReference type="OMA" id="CIMFVLF"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF47">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="35"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46043" checksum="24033FC87590B4B7" modified="2015-04-29" version="1">MDEVSAFVTAPSSAFDDTLTPTTASPWSEGQQTALKAATVTTCCLSIVGCVLIILSFVLLKDLRATSRQLLVFLSLADLVTAMGNMVGVLTDDTGTLCVIQSSFTTYSSIASFLWTSSIALYLYLSIARESQRLAARSIPFLHVFSWLTPACIIIAALACEVLGSDDFSATTVGWCWIKSNVKYDLFWKLFAGKGWEIASYISVPILYFFVKRKIRVELHSAEQIQLVSRRSVQVAQEADRKMTFIPIVFVFVRSWGTTRFLISEIGSQEQADVFWLTLCQAIGDSSQGFANFVLFCVLTPKIRNRMIALVWPQYRGSNADESQRYSGSVATTASAAKSGAYPNLGRGSFNQVVPRSQHNQQQQQLRQGGGGGGGASSHHGSVDNGYYSTSLSSSVNPPNYDPSPGSYSSLSTRDSSYYGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJV6</accession>
    <name>A0A0D2WJV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366038.1">
        <property type="nucleotide sequence ID" value="XM_004365981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJV6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJV6"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJV6"/>
    <dbReference type="OMA" id="QIMAMAV"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254423" description="Nucleotide exchange factor Fes1 domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="5">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="61633" checksum="2B1BEFDE9995EBE6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK61</accession>
    <name>A0A0D2WK61_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xenotropic and polytropic murine leukemia virus receptor xpr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364741.2">
        <property type="nucleotide sequence ID" value="XM_004364684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK61"/>
    <dbReference type="FunCoup" id="A0A0D2WK61">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK61"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK61"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="9">
        <location>
            <begin position="671"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="936" mass="105083" checksum="6C3484544621042F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKD8</accession>
    <name>A0A0D2WKD8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI ethanolamine phosphate transferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKD8"/>
    <dbReference type="FunCoup" id="A0A0D2WKD8">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKD8"/>
    <dbReference type="InParanoid" id="A0A0D2WKD8"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKD8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1125"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="621"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="968"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1235" mass="136233" checksum="86F027452DB3A23F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKM3</accession>
    <name>A0A0D2WKM3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKM3"/>
    <dbReference type="InParanoid" id="A0A0D2WKM3"/>
    <dbReference type="OrthoDB" id="6153129at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="97" mass="10791" checksum="AA6130F7A73A83E1" modified="2015-04-29" version="1">MNVDIQDSDINDYMRDVYKAIHTKADKIPTSRKLVGVLQATKICLFSPLLKWYLEHGLVITPVYSLRHLVLGLIALYCGPIIVGQDEPATECSSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKS9</accession>
    <name>A0A0D2WKS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat and death domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKS9"/>
    <dbReference type="STRING" id="595528.A0A0D2WKS9"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKS9"/>
    <dbReference type="OMA" id="WFFISHE"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000307">
        <property type="entry name" value="Leucine-rich repeats and death domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="275"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="405"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="697" mass="78689" checksum="73DCAC133FB13AD2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKT1</accession>
    <name>A0A0D2WKT1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="3">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ROX family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364494.1">
        <property type="nucleotide sequence ID" value="XM_004364437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKT1"/>
    <dbReference type="InParanoid" id="A0A0D2WKT1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="404"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="908" mass="100859" checksum="C4B9CAA68650A086" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW5</accession>
    <name>A0A0D2WKW5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364548.1">
        <property type="nucleotide sequence ID" value="XM_004364491.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKW5"/>
    <dbReference type="eggNOG" id="KOG0515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKW5"/>
    <dbReference type="OMA" id="TAPLPHM"/>
    <dbReference type="OrthoDB" id="10038642at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Ras-associating" evidence="10">
        <location>
            <begin position="635"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1663"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1721"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1364"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1508"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="820"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="943"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1187"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1364"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1799" mass="188661" checksum="294C12C4339ABAA2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKX3</accession>
    <name>A0A0D2WKX3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348995.1">
        <property type="nucleotide sequence ID" value="XM_004348945.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKX3"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKX3"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="773"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1703"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1508"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1966"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1508"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2047" mass="219720" checksum="E4978EF18CD1BAB2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLS4</accession>
    <name>A0A0D2WLS4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLS4"/>
    <dbReference type="STRING" id="595528.A0A0D2WLS4"/>
    <dbReference type="eggNOG" id="ENOG502QUN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLS4"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLS4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007141">
        <property type="entry name" value="PRK09585.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="505" mass="53631" checksum="3D374E882E36B5A4" modified="2015-04-29" version="1">MNKRCLSRSTNTAPIQSRSAQSTPFWFFVFLMAEWCVGLMSGTSVDGIDCALIQTDGERVFWPRAEEQGKEDLTGSTGTTNSELAYLVPYDPAFQRELRSLFGVDTSAVLAGTSEVDTSRSTVIRIEQDLTERHAAAVAPLLARAARTDRHVALIGMHGQTVFHRPASAHPPDAPAPGITCQLGDGNLLAELTKVPVVFDFRTADVALGGEGAPLVPVFHQALCRSLSRTLLAKLGMYQQQRELVLGILNLGGVGNITFVRLKPAAQHTDTPGSAVVPVHALPGAGEDFVSEDGLDLLALDTGPGNALVDDWMLANTQVPCDFDGVAAASGTVDGGVLAKLMAHPYFDRVPPKSLDRQSFALSVPECGLVAPACSVADGAATLTAFTAASAIASTQWACFCADGPKLRCVTCPRVSGILVCGGGRRNATLMRMLRDRAQALAVVLRPVEDVGWDGDLLEAQAFAFLAKRVQQSQPTSFPRTTRVSKPVCGGRIAVPQVPQAEMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLX9</accession>
    <name>A0A0D2WLX9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ subfamily B member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349543.1">
        <property type="nucleotide sequence ID" value="XM_004349493.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLX9"/>
    <dbReference type="FunCoup" id="A0A0D2WLX9">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLX9"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLX9"/>
    <dbReference type="OMA" id="FAGRDFY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLX9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="41229" checksum="FD80CBF05B030A9C" modified="2015-04-29" version="1">MPAQSADYYKVLGLPKGTSDADAIKKAYRKAAMKWHPDKNPNNKTEAEHKFKEISEAYEVLSDPQKRQVYDMYGEAGLKGGAPSGGDEGAGGGGSAGGGPGTFYFSSGGAPGRGGMHFTPSNADDIFRQFFGGSGADMFGSPGASGSSSRSRAGRGARVDPFSSMFGGMHGGMGGMGGMPGGMGGMGGMGGMHGGMSGSDDDDDVQFTHAAAPRKPQVLTRALPVSLEDLYRGTEKKLKITRKIQDSATGKVVETSKILTVNIQPGWKAGTKVRFSGEGDELNGQPAQDVVFVIEEKPHSHFKRDGDQLTTKIQVPLVNALVGFKAKIPTIDGSVAELQITDVLTPGFKRIISGKGMPTKSGVRGDLLVEFDIVFPAALSPAQKDAVKRAFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNB0</accession>
    <name>A0A0D2WNB0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase activating protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348392.1">
        <property type="nucleotide sequence ID" value="XM_004348342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNB0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNB0"/>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNB0"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNB0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="405"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="623"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="817" mass="87393" checksum="15A8520CB2DC0EF5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNF3</accession>
    <name>A0A0D2WNF3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363821.1">
        <property type="nucleotide sequence ID" value="XM_004363764.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNF3"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNF3"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNF3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="3285"/>
            <end position="3453"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="3465"/>
            <end position="3757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="4052"/>
            <end position="4093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1465"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2009"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2093"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2369"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2407"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2467"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3875"/>
            <end position="3909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4121"/>
            <end position="4145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4337"/>
            <end position="4381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1474"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2010"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2093"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2467"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3875"/>
            <end position="3891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4121"/>
            <end position="4140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="4381" mass="468633" checksum="A441E1A1D3114838" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNV1</accession>
    <name>A0A0D2WNV1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxylase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNV1"/>
    <dbReference type="STRING" id="595528.A0A0D2WNV1"/>
    <dbReference type="eggNOG" id="ENOG502QPVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNV1"/>
    <dbReference type="OrthoDB" id="1365747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.90">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523:SF6">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00048995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="743" mass="82280" checksum="231420CE56648069" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNW2</accession>
    <name>A0A0D2WNW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364025.2">
        <property type="nucleotide sequence ID" value="XM_004363968.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNW2"/>
    <dbReference type="STRING" id="595528.A0A0D2WNW2"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNW2"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254521" description="LRRNT domain-containing protein" evidence="12">
        <location>
            <begin position="26"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="13">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="764"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="815" mass="82868" checksum="07E5BEBBEA4CE508" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNZ8</accession>
    <name>A0A0D2WNZ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364105.1">
        <property type="nucleotide sequence ID" value="XM_004364048.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNZ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WNZ8"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNZ8"/>
    <dbReference type="OMA" id="IGNACDY"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="37086" checksum="ED3299F3C0C6B3D1" modified="2015-04-29" version="1">MVVTTRSRSTNNSARFIIDTVPDSTASATESVAAAADAAGSAPEPAEVASAKMMSELRFKPLCRCHEVPQFLRQNFIERGYRGEISDTRAILLSLFRLHNETFNVWTHLVATIGVVALGIYTILYYSSIATLDQLIAFSLFFLSAGACFLLSSIYHLFSCHSFAVYRKVIVLDYMGVFTLILGSFLSGLHFSFHCFPTARMVYQGGILLLCLSGCVLALMPAFDAPQFKLWRVASYVATAGFAVFPLVHGAFLFGSENTWRWWSVLALYGLGLFFYVSKFPESKFRGRFDIFFASHQIWHVCVVLAAFWHYCTLHHFLHRITTESCDQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPR5</accession>
    <name>A0A0D2WPR5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363366.1">
        <property type="nucleotide sequence ID" value="XM_004363309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPR5"/>
    <dbReference type="FunCoup" id="A0A0D2WPR5">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPR5"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPR5"/>
    <dbReference type="OMA" id="RNANFCE"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPR5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="247" mass="26644" checksum="86B308C0DC3A7DED" modified="2015-04-29" version="1">MSVQCTQRLQKEYRMILKDPVPYIRAVPRTSNILEWHYVITGPENSPYHNGLYHGKLVFPKDYPFKPPAISMFTPSGRFQTNTRLCLSMSDFHPELFNPAWSVASILTGLLSFMLESTPTTGSIESSDETKRQLALESAAVNLKQPLFCELFPELVEEIKAKAAAAAAAAETSSSSSSAPSTENPANNAPASPDNKPVAAGAGAASPARKNNRSAKHDPPTFLSNAVAAMLIGVFAAIVYCVLQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQL4</accession>
    <name>A0A0D2WQL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQL4"/>
    <dbReference type="STRING" id="595528.A0A0D2WQL4"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQL4"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="237" mass="24996" checksum="0D09851E428E00E5" modified="2015-04-29" version="1">MMQKDDEVGKIAQGAAVSVGKAAELFMQHLLKQLNQVAKDRDTRTITPAHLKECVKTNQMFDFLADIVAKAPDLPPPGQESKPKTGAAAAKESRAKRPRKARSEDDQASKPSKAEAVDDSDSDGDDWEADSDDEDQKPRKRRPSKPATVHGQKGKTAAAPAPPSSSSSSSLASSSSSSDAAPVAPFAFVNFQSSSSSAPVLGTPAPLVSPTVAMPRAPVPTASTNKQPKEEDEDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQW8</accession>
    <name>A0A0D2WQW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rbm13-prov protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348095.1">
        <property type="nucleotide sequence ID" value="XM_004348045.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQW8"/>
    <dbReference type="FunCoup" id="A0A0D2WQW8">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQW8"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQW8"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="388" mass="44137" checksum="AEFC9D250AA03460" modified="2015-04-29" version="1">MQHDEVIWSVINNHFCSFKVKTQTQTFCRNENNITGLCNRQSCPLANSRYATIKEQNGILYLYMKTIERAHMPSQLWERVKLSKNYEKALEQIDTNLAYWPKYIVHKNKQRFTKITQMLIRMRKLKLKSQEKLVTVNKKVERREARREEKALVAAHIEQSIEKELLERLQKGTVYGDIYNFPTQAFEKALDEQEIEDAELEEDQDDDDNSGNREFVEDFDDENDYIDDLEDGQEFEFEEEDGDDDMMEIDEDDDGNDDDDGEDMDDMDDDDDDEDEDDDVAPVQTRRGAAAAASSNKALRGKAAAGVDKFMAELAQKAQAAAAKKGGKPPVSSGKPSAADVAPRRSTRGAAAPAQPPKGAKRRGGAAGGRVEIEYEHEDEHGLRQTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRS2</accession>
    <name>A0A0D2WRS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347457.1">
        <property type="nucleotide sequence ID" value="XM_004347407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRS2"/>
    <dbReference type="STRING" id="595528.A0A0D2WRS2"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRS2"/>
    <dbReference type="OMA" id="SRYFIER"/>
    <dbReference type="OrthoDB" id="6150516at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="10">
        <location>
            <begin position="520"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="757" mass="82486" checksum="3EA69B68A5282F90" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRV3</accession>
    <name>A0A0D2WRV3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRV3"/>
    <dbReference type="FunCoup" id="A0A0D2WRV3">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRV3"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRV3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="111"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="514" mass="57879" checksum="DFC96353818370CB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRW6</accession>
    <name>A0A0D2WRW6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5'-3' exoribonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347511.2">
        <property type="nucleotide sequence ID" value="XM_004347461.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRW6"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRW6"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="10">
        <location>
            <begin position="1142"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1558" mass="168555" checksum="91720A05F8F7839F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRX2</accession>
    <name>A0A0D2WRX2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRX2"/>
    <dbReference type="STRING" id="595528.A0A0D2WRX2"/>
    <dbReference type="InParanoid" id="A0A0D2WRX2"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="877"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128974" checksum="9EC1C9DDB1D1E69D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSG2</accession>
    <name>A0A0D2WSG2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alliinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alliinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346719.2">
        <property type="nucleotide sequence ID" value="XM_004346669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSG2"/>
    <dbReference type="STRING" id="595528.A0A0D2WSG2"/>
    <dbReference type="eggNOG" id="ENOG502QQJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSG2"/>
    <dbReference type="OrthoDB" id="2020362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.30">
        <property type="entry name" value="EGF-like, alliinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006948">
        <property type="entry name" value="Alliinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037029">
        <property type="entry name" value="Alliinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF20">
        <property type="entry name" value="TRYPTOPHAN AMINOTRANSFERASE-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04864">
        <property type="entry name" value="Alliinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254625" evidence="3">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Alliinase C-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="488" mass="53074" checksum="C64453599C91F02B" modified="2015-04-29" version="1">MQAQLFPLLIPLTLLLLLASGGAIQAANAQVNLCDSRPKVDPCMPGGWWDPLLGSCQGYDGSDCFACFYGPNCKSFNASSACPVDSGAGQPVLFREYWASTGLPCDAVPADYRTPYQLLNSEQPIKPLADAIRSLHRLVGNVNAENYTIVPTYGSTQAMMAALYAMTSLHASAGGQLQVFAQAPYYASYPNQVLSTFAPVAGGVATAAWNPLADPAALSTVEILTYPNNPDGTLRRPLVSDPTRVIYDCVYYWPHYQNESSFVPLDKDIMLFSASKMTGHAGSRFGYALVKNATIAAIMREYLSFSTIGVSIDTQLRLLDIIQSLVSSFAAEAPAPAVDAGATLNPYFSFAQSRMTAHFTSLASVFESNVSAHQYTFINRLQGGAFAWIQCPPNYDCYALFEQVALLGNSGIPYGASSNFVRFSMMMPESEFAQLLGRVHQRLYEVPLPELTDDLRADLKDKAAYIGQPKLQGREQLLRSAAELQRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WST7</accession>
    <name>A0A0D2WST7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345418.1">
        <property type="nucleotide sequence ID" value="XM_004345368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WST7"/>
    <dbReference type="FunCoup" id="A0A0D2WST7">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WST7"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WST7"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WST7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="386" mass="42945" checksum="3E615F82CDFAE0DC" modified="2015-04-29" version="1">MLPATLRSVRSFSTSVRAAASDISFANLKVQKAAPEARKTKPANKDLVFGASFSDHMLEVPWNKQSGWAAPIISPYHRLSIDPASNVLHYGIECFEGMKAYKDKHNQIRLFRPDKNMARLKSSCERIALPSFNTNEFLNCIKELVKLDADWIPKEKGYSLYIRPTAIGTQESLGVGASNSSLLFVINSPVGPYYKTGFAPVKLLADTNNVRAWPGGTGGYKLGLNYAPTILPQLKAMEDGCQQVLWLFGPELEITEVGTMNFFMFWKNQNGETELVTPPLKDIILPGVTRDSILSLARSWGEFKVSERNFTIHDVVRGIKEKRVIELFGAGTAAIVSPIGCIKFEGQDYPIPLELGGSGKLTKRFFDTMMSIQYGELEHEWSVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTK4</accession>
    <name>A0A0D2WTK4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RasGEF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344993.2">
        <property type="nucleotide sequence ID" value="XM_004344943.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTK4"/>
    <dbReference type="STRING" id="595528.A0A0D2WTK4"/>
    <dbReference type="eggNOG" id="KOG3541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTK4"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="183"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="398"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="674" mass="72798" checksum="8A911262DD4AA71D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTS1</accession>
    <name>A0A0D2WTS1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345092.2">
        <property type="nucleotide sequence ID" value="XM_004345042.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTS1"/>
    <dbReference type="eggNOG" id="ENOG502SE54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTS1"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1813" mass="194066" checksum="0490F47DE26E37CF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU26</accession>
    <name>A0A0D2WU26_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345196.1">
        <property type="nucleotide sequence ID" value="XM_004345146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU26"/>
    <dbReference type="InParanoid" id="A0A0D2WU26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="145" mass="16137" checksum="6A1C38A3BD19E497" modified="2015-04-29" version="1">MVCHTTETVLEIVYCFAAAAAAFVFGGMYHGHPFIHESFMRESKLQPSPHTKWPLIIEYLTALVKFVALNLLATELGVTSIAGKLSLAAALWFAFDFLPTAAEYVWAGRSFVLLAIHGVYHLSYLFVGLYTVKSLEYASKHLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU97</accession>
    <name>A0A0D2WU97_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345293.1">
        <property type="nucleotide sequence ID" value="XM_004345243.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU97"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU97"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="3664"/>
            <end position="3773"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="3786"/>
            <end position="4077"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="4560"/>
            <end position="4601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1530"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1632"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2138"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2525"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2703"/>
            <end position="2749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2828"/>
            <end position="2906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3068"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3136"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3601"/>
            <end position="3658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4119"/>
            <end position="4151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4166"/>
            <end position="4213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4425"/>
            <end position="4447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1642"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2138"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2525"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2703"/>
            <end position="2717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2735"/>
            <end position="2745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2841"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2886"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2897"/>
            <end position="2906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3136"/>
            <end position="3162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4119"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4181"/>
            <end position="4202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4434"/>
            <end position="4447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="4741" mass="504817" checksum="E1B8AA3B8E0A40E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUS8</accession>
    <name>A0A0D2WUS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344409.1">
        <property type="nucleotide sequence ID" value="XM_004344359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUS8"/>
    <dbReference type="FunCoup" id="A0A0D2WUS8">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUS8"/>
    <dbReference type="eggNOG" id="KOG2488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUS8"/>
    <dbReference type="OMA" id="AYLHYRF"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="67"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="240" mass="27474" checksum="06AB822067D4A35E" modified="2015-04-29" version="1">MKTPKGLREHQKLLDLANANTSYLDKLKPFSKFNRNGLDVALSTRHASELSKEDMEFCFNLTKTNMETIRSLTSAVDDFRTCTALLKRYNASSWGWSDQRKRTELKEDTARFLLARSQSSADGAPGQLVAFVHFRFDFESTADEAQIPVIYCYEIQLSEPVQRKGLGKFMMQIIELIGIQEKMLKSMLTVFQANTSAIKFYRTILNYEIDEISPSQCDDDEADYEILSKRLPHRASLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV03</accession>
    <name>A0A0D2WV03_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345055.1">
        <property type="nucleotide sequence ID" value="XM_004345005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV03"/>
    <dbReference type="STRING" id="595528.A0A0D2WV03"/>
    <dbReference type="eggNOG" id="KOG2836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV03"/>
    <dbReference type="OMA" id="IQVHGWT"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-tyrosine phosphatase catalytic" evidence="10">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="19219" checksum="850E32600B75526F" modified="2015-04-29" version="1">MVKEAKIPNPPSYIEFAHMRFLIMDAPSDSNLPAYITELKKHEVSDVVRVCDPTYNTEPLTRNDITVHDWPFVDGEAPPSTVTDNWLNLVNQRMSPAVQKEGKHPCIAVHCVAGLGRAPVLVAIALIEAGYEAEDAIELVRSKRKGAINNKQLLFLQKYKRRSKTPGKCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV22</accession>
    <name>A0A0D2WV22_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270696.1">
        <property type="nucleotide sequence ID" value="XM_011272394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV22"/>
    <dbReference type="STRING" id="595528.A0A0D2WV22"/>
    <dbReference type="eggNOG" id="KOG3976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV22"/>
    <dbReference type="OMA" id="HMINWVD"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="234" mass="25236" checksum="C6C5FDDE15F23A65" modified="2015-04-29" version="1">MASLIARRLPLLAASSARAFSSKAAGARALGASEAPKKPEEPSKGGLAKLISEKTGNTGALLLASGLAAVGISKEIIILHHETIMVGSFGLAAYFIYKNIKQPVAEMLDQDYQASVNSLQQFRDVQREKLAKDRKAAEQYLNTTDLVQDLRGFLNNLNEVDAEVRAREQYANVAAELKKSLDLAVSVVQAARRQEQLDLADALEQSLLNQGLSKEDDAAYLKKCLSDLAALAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWB1</accession>
    <name>A0A0D2WWB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LARP2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343754.1">
        <property type="nucleotide sequence ID" value="XM_004343704.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWB1"/>
    <dbReference type="STRING" id="595528.A0A0D2WWB1"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWB1"/>
    <dbReference type="OMA" id="YMTLMEA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="397"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1054" mass="110511" checksum="045C146008A2A8D5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWD0</accession>
    <name>A0A0D2WWD0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_007058</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343782.2">
        <property type="nucleotide sequence ID" value="XM_004343732.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWD0"/>
    <dbReference type="FunCoup" id="A0A0D2WWD0">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWD0"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWD0"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWD0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="356"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="486"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="565"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="639" mass="70634" checksum="CFFEE2C7290E90A0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ8</accession>
    <name>A0A0D2WWZ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270769.1">
        <property type="nucleotide sequence ID" value="XM_011272467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ8"/>
    <dbReference type="InParanoid" id="A0A0D2WWZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="68" mass="7283" checksum="777F1A7BBE0C6267" modified="2015-04-29" version="1">MPFFSSTLGLNQENGRTTRAQTAVPVKTTALSTAPTTQTTRQVMENISNRVVQARTDATVGKTRSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX35</accession>
    <name>A0A0D2WX35_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="22">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_007752</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342825.2">
        <property type="nucleotide sequence ID" value="XM_004342776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX35"/>
    <dbReference type="STRING" id="595528.A0A0D2WX35"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX35"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX35"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266645" evidence="20">
        <location>
            <begin position="29"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="631"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE97640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1024" mass="107212" checksum="4409FBADEF0BCA61" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXF8</accession>
    <name>A0A0D2WXF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXF8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXF8"/>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXF8"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="44948" checksum="ACCFA771E5DA151B" modified="2015-04-29" version="1">MAEQPTTSVETTTPMAARRTPSAASSPLDLKVQIKHLLDSLGTRAQDTAGPGVGRAAAAAGGRTGRGQFPALAALAAVPAAPVRTLPAGTVVIPSALCRPWERADYVQRLATFCSIPRWCAKPALLAPLECARYGWFNCDVDMLECVSCHSRLSAQLSDSPSETAIRKVHTQLSLNHKDLCPWLNSSCPDSFKQVVLSPPATAFAAFLERCTSLIGLGENLPAVSPEDRAEVSGRVETFNQLVQRVQDALAQPSIARSTIEKAALWALCNWSASRLEHAPTQQVLSCNICLRQFGLWNVPPKDVHHASDASAMSSESAAPAPAGQAANKRTSEVDTSRPAKLPRMAEQSSVHELQRQLFAEHRWYCSCSSTAAPTVASRLLDVLCPSTTSPVFHRNMPSADAVHSVKQALRQSTASNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXW6</accession>
    <name>A0A0D2WXW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXW6"/>
    <dbReference type="FunCoup" id="A0A0D2WXW6">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXW6"/>
    <dbReference type="InParanoid" id="A0A0D2WXW6"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="126" mass="13984" checksum="B85CB570CBB7EB7D" modified="2015-04-29" version="1">MGRLTIDTRCCMCAATADLASSKALPFCKDCGTVLDLSADDDYASCNACGKSREMADFELQVTRSYSHPFAFQKPKYNTMKVGKTKGATINEKCPSCGHPEMMFRTMQLRSVDEGQTVFYDCEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X033</accession>
    <name>A0A0D2X033_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364892.2">
        <property type="nucleotide sequence ID" value="XM_004364835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X033"/>
    <dbReference type="FunCoup" id="A0A0D2X033">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X033"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X033"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X033"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="172"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="387" mass="43405" checksum="DB212658CBC5672F" modified="2015-04-29" version="1">MAALTLLRSLPRAVVTVSASSSSGLMRGSVITAGRSGSRSGALAAPCLARRSARCFSTMTQPSLAQRSFQSNYEQQQQQQQQRTPPHNSKLRFRVKEVALHSTSFRLFVGGVAALLAYAWYQAEEVPFTGRRRMLLLPAWLEKLIGNQTDQGLVAETREMWVSESSPAYQLIREVGERICTANGIPPLRYHLVRSNEPNAFVTPGGTVFVYTGILPIMQNEHGAAVVLSHEIGHYIAHHSSEQVLFSVILGAFRLLWDWNSALLSSVFKVAAELPLSRSRETEADLIGLMLMARACFNIDEAQQVWKRFDDLAHQDNPVDRAEKLKSWLSTHPSHSERLKNFDPKGEWMAKARVEQDKACLYGQALEEQPSSPLSRILRRHRERRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0I2</accession>
    <name>A0A0D2X0I2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Asterix</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0I2"/>
    <dbReference type="STRING" id="595528.A0A0D2X0I2"/>
    <dbReference type="eggNOG" id="KOG3462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0I2"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0I2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12780" checksum="2D9A25FC5B5900DB" modified="2015-04-29" version="1">MTFASSLHSVIFLRMSDTPASLASLAAADPRRPNAVSPFKPPAAASANDDYYSFFSLILGMLGLFMKQKWAAWAAVYCCLFSFANMRSDGDVKQLLTGVTFAVMSVVLLYLQPVADAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K5</accession>
    <name>A0A0D2X0K5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365606.2">
        <property type="nucleotide sequence ID" value="XM_004365549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0K5"/>
    <dbReference type="eggNOG" id="KOG4270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0K5"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0K5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="79454" checksum="DC5D2D2B37479739" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X108</accession>
    <name>A0A0D2X108_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rab5-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X108"/>
    <dbReference type="STRING" id="595528.A0A0D2X108"/>
    <dbReference type="eggNOG" id="KOG3415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X108"/>
    <dbReference type="OrthoDB" id="286395at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X108"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14989" checksum="9099DE7ABD8D237F" modified="2015-04-29" version="1">MQRTQAGAKVAAAASKASDASAQPSSSSSGASSLGASAPARLLFGKNLAEKEGVLDVLYWARQIAAILVGVLWGLFGFTGLVAIIGFGIASTAITIAFLVQIVQVDEDEFGGRWELVKEGFMPSFSLFLVRRLGAFLMVAFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X116</accession>
    <name>A0A0D2X116_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X116"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X116"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X116"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254948" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2203"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2321"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2234"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2266"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2388"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2278"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="2396"/>
            <end position="2410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2456" mass="256201" checksum="260618A6319403F2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X141</accession>
    <name>A0A0D2X141_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364365.1">
        <property type="nucleotide sequence ID" value="XM_004364308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X141"/>
    <dbReference type="STRING" id="595528.A0A0D2X141"/>
    <dbReference type="eggNOG" id="KOG0913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X141"/>
    <dbReference type="OMA" id="PLMSCMA"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X141"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270324" description="Thioredoxin domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="261" mass="28290" checksum="8A54C9BAA40CF27B" modified="2015-04-29" version="1">MRFSLCALFLVVAAAAFVAAPAASAAASHDRPAPFIIALDTSNFDEKVAHGEWLVAFKADWCGYCKRLHPDFESLARESIINVGEVDISKNSALAARFMISALPTVYHIVNGEIRTYTKTRSLNDIRDYITREEWRNDEPTPFWKSPLAPHFRVLGLTLSLGAMAQDYYKVLTEDYQFSQAAVIAIFVGAIIAAGIAFSFVLLFIMAFVDLIRGTKPAPAPQPRGATAQTTGAPAQAAATSAEPGQPAPTIGKSPRTKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1G8</accession>
    <name>A0A0D2X1G8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1G8"/>
    <dbReference type="InParanoid" id="A0A0D2X1G8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="128" mass="13928" checksum="3E8F895DDA1D32F1" modified="2015-04-29" version="1">MRLKMRHQSAAELGFLQVGVEFAALKEAAWRAWPTLLAVDQRPGKEAARLVPGVLLAWSLGAELLPVVTPSALRPSVQGVRLAWHPKAGLLAVVKPTTNLAWRLGAGLRPVGNPRALKQSVQPKARWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1I0</accession>
    <name>A0A0D2X1I0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348836.2">
        <property type="nucleotide sequence ID" value="XM_004348786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1I0"/>
    <dbReference type="STRING" id="595528.A0A0D2X1I0"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1I0"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1I0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254957" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="257"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="394"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="522"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="858"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123007" checksum="C532D79D4B489B92" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q4</accession>
    <name>A0A0D2X1Q4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349128.2">
        <property type="nucleotide sequence ID" value="XM_004349078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q4"/>
    <dbReference type="FunCoup" id="A0A0D2X1Q4">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1Q4"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Q4"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Q4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="248"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="813"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1251" mass="136566" checksum="2ACB35AAED34F2CC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X244</accession>
    <name>A0A0D2X244_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X244"/>
    <dbReference type="FunCoup" id="A0A0D2X244">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X244"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X244"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X244"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="264" mass="29827" checksum="1FF276CBE68A8BD6" modified="2015-04-29" version="1">MCSAVEHDQLHLTLFVAILIDILKNAGIAQVVATALVYFRRFYFRVDWAACDPLLAITTCLYLSAKVEETGIIPVYSIITQAQYVCNNEMDLIFQNAFNFTVNDVVESEFYILEELGCYLIIFHPYRPLTHYCHGLDDKQLLTTAWFILNDSYRTDLCLQYPPYMIALAALYLACIMKEKQLSPKMVEWFAELNVNPEELIEIATPILALYETWETFSSDKQAVRDALSRIPKPERAAAAAAAAAPSTSSPALLSNSYPQQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2M3</accession>
    <name>A0A0D2X2M3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aladin seven-bladed propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2M3"/>
    <dbReference type="STRING" id="595528.A0A0D2X2M3"/>
    <dbReference type="eggNOG" id="KOG2139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2M3"/>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2M3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="3">
        <location>
            <begin position="351"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="739" mass="76929" checksum="32747C6048DEEC9D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2P0</accession>
    <name>A0A0D2X2P0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2P0"/>
    <dbReference type="FunCoup" id="A0A0D2X2P0">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2P0"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2P0"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2P0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="100"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="517" mass="57004" checksum="1DDCCE96539C3BB0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q4</accession>
    <name>A0A0D2X2Q4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363562.1">
        <property type="nucleotide sequence ID" value="XM_004363505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q4"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Q4"/>
    <dbReference type="eggNOG" id="KOG0507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q4"/>
    <dbReference type="OMA" id="AMFNKKD"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Q4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="663" mass="72512" checksum="50D94AE7BBCCEE50" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q7</accession>
    <name>A0A0D2X2Q7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363575.1">
        <property type="nucleotide sequence ID" value="XM_004363518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q7"/>
    <dbReference type="eggNOG" id="ENOG502STD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q7"/>
    <dbReference type="OrthoDB" id="5956754at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="945" mass="103728" checksum="51852AE852923562" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T1</accession>
    <name>A0A0D2X2T1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363667.1">
        <property type="nucleotide sequence ID" value="XM_004363610.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2T1"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T1"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="83"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1355"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1589"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1814"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1905"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1604"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1640"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1667"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1682"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1814"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1937" mass="220022" checksum="ACF8CD0C6F47F06D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X453</accession>
    <name>A0A0D2X453_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pirin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345498.1">
        <property type="nucleotide sequence ID" value="XM_004345448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X453"/>
    <dbReference type="STRING" id="595528.A0A0D2X453"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X453"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X453"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000055">
        <property type="entry name" value="pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34059" checksum="B88963ADA9B02842" modified="2015-04-29" version="1">MSAALSTPIKFLSRRVVKSILGVEQGEGVGARVRRSIGRPELGRLDPFLMLDYFTGVPPAGFPDHPHRGFETVSYLLEGKFAHEDFAGHKGVLNAGDLQWMTAGRGIVHSEVPLTKSVGLQLWVNLARKDKMIEPNYQELLKKDIPVATKDGVTVTVIAGSSMDIDSAVYTRTPTMYLDFKLDPNSSFNQAIPKGWNGFAFTISGKAYFGPADSAVEEKPFHTVLLDNDESADGVTFSTKDEPAHFVLIAGKPLNEPIVQHGPFVMNTREEIMQTIRDYQERKNGFERAAGWYSEAGRTQYGLGEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4F0</accession>
    <name>A0A0D2X4F0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345079.1">
        <property type="nucleotide sequence ID" value="XM_004345029.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4F0"/>
    <dbReference type="STRING" id="595528.A0A0D2X4F0"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4F0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4F0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="254"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="524" mass="57633" checksum="F79E15ECC85BF2A2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4M9</accession>
    <name>A0A0D2X4M9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="12">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006679</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M2 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344300.1">
        <property type="nucleotide sequence ID" value="XM_004344250.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4M9"/>
    <dbReference type="SMR" id="A0A0D2X4M9"/>
    <dbReference type="STRING" id="595528.A0A0D2X4M9"/>
    <dbReference type="eggNOG" id="KOG3690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4M9"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4M9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255504" description="Angiotensin-converting enzyme" evidence="15">
        <location>
            <begin position="25"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="744"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="245"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE96339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="865" mass="93898" checksum="0330EDDCAA8D22B1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4N2</accession>
    <name>A0A0D2X4N2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eapp protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344313.2">
        <property type="nucleotide sequence ID" value="XM_004344263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4N2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4N2"/>
    <dbReference type="eggNOG" id="KOG3395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4N2"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4N2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="481" mass="53123" checksum="A11C9CD517C1D8B6" modified="2015-04-29" version="1">MQPQSAPMRVGAGMGPVRPPLFGLAYDQAHADDDDVDDDDDERSASGFRGYDDDDGDDDDDDDEQLGLRVDGGMAGRDLDEDDGGDDLEDEAAGGRSTDPRRRELLEFETDMLRDMIMAFKVDEKRERAREKQAQADAALAEAKRRRHEAWLETHPTPGSAPEKASGAFEVPLQATAQAGGSSRQDSTTRTVRTAPFVLNSHQAFNAMPTPWSDRAKVADVAGNGQSGQSASRMDVNAGESISEADLLEEVVRNHAQATKEQQQKFYDDSYFDSDEEELEVDPHASTNNSNNNKPQSRRRRVAQPTNEDLMYDPVVDDEDDRWMQQQRQFYRNGIDPFKTSTEAKASEPPNSANSQQAAQPSKARIESDAILSCPFCWTTVCIDCQQHTQYNNQFRAVFALNCTIARAEQLQPGAQPSSSSSSKSSNRNTRKNRKLSRGQNDAAADTGPLHPVRCTECNTELGVIDGDEVYHFFNVLASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Y7</accession>
    <name>A0A0D2X4Y7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343856.2">
        <property type="nucleotide sequence ID" value="XM_004343806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Y7"/>
    <dbReference type="InParanoid" id="A0A0D2X4Y7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="322" mass="33584" checksum="306E2799A6397173" modified="2015-04-29" version="1">MLTMGILAAPKPVKASSAHSQPQSRQQSPSPKLLQQPRPASAAVLIQPQPSAATNSNSNSARPRVQPLTVSNPVAVPSTRARAIPNHGSFDSDSHAELQGILLQHGATSADARALFPASPPTRAANPMAMNDPFFMPHHQPGVELGLLSPSPPPTALAASSIRAMANSPTKGFPLHQTPPLQYRHNNQHDEGFFVGSPSQQSMIYSVNGHSHHHHHTGGVDNLVYANTSFSGSHPFSGVGSHPGSSGLSLTIPPTALGMASSGNGSGTASPNPSSPLSPRSYSRARFGRKVVAQQAPPPSSTNRAQGRKKAHSFGDEPLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5T2</accession>
    <name>A0A0D2X5T2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346396">
        <property type="protein sequence ID" value="KJE98354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5T2"/>
    <dbReference type="InParanoid" id="A0A0D2X5T2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270446" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="123" mass="13170" checksum="99CF48ACE51E48F4" modified="2015-04-29" version="1">MLSGRLVTTVAFLVLAALVHNSSGAYQIRNLHFLSPTQNTAVSCTSSSTQLDSVDAITHPTPHPNPPHPTSFHSTPTIPITTIPTTFTSTTIFITVITAVPDAIYCDCPYASERGLNSIADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5T3</accession>
    <name>A0A0D2X5T3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346398">
        <property type="protein sequence ID" value="KJE98359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341229.1">
        <property type="nucleotide sequence ID" value="XM_004341181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5T3"/>
    <dbReference type="InParanoid" id="A0A0D2X5T3"/>
    <dbReference type="OrthoDB" id="199238at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="142" mass="15360" checksum="4F86B09910A17ADB" modified="2015-04-29" version="1">MEMNDLGLYTSDDDTMTAMSLSSGQLRLTAPDPGAYWYTLLANANQCRDMSSYAAIQFSIQAPVGTKLILQLQFRNDRCKGWEGSSELQLAGFTGAQQTIRVPFTDFDTAVPASRLFAVSVFGLSGSPAPISISLDDLVFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZH1</accession>
    <name>A0A0D2TZH1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZH1"/>
    <dbReference type="InParanoid" id="A0A0D2TZH1"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZH1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="135" mass="14892" checksum="AFBA46845D186C67" modified="2015-04-29" version="1">MVLAIMTLLREQAISQPFQPAVSVSHLRDEIIDVSDRKRLAARWDEACKIVRRDSRVAQSVQSIHGIPQDMLSWVSPVVVASPMAAQRQASPLVDNPDNADNGGGDENDRQPAIRSPQAQHRPYASSIYPNIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0H3</accession>
    <name>A0A0D2U0H3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0H3"/>
    <dbReference type="STRING" id="595528.A0A0D2U0H3"/>
    <dbReference type="eggNOG" id="ENOG502QPSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0H3"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0H3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="407" mass="44049" checksum="0791BD3AE46F2676" modified="2015-04-29" version="1">MAEISKSKEYAAFRNSVALKTVVGETVEGEDKAWRLYDYGPRSVASPLIFFPPASGTADVYFNQIASLGSQGYRVIAVEYPPYWTHTNWAEGFRKLLDAMGLNKVHLFGASLGAFLAQKFAEYMYKTERVQSLFLCNGFPDTSVFTDMPYAGTYWMIPAFLLRRLLLSNFPEASVEPRIADSIDFMVERLESLKQAELASRLTLNCLEAYVEPQKLSRVPVTIMDVFDECAISNRVKEDLYKCYPHAKLAQLKSGGNFPYLSRPEEVTMYIQVHLRQFTGTDVDPCANTLVQTLNNAAAAAAATSSSSSSKKNGSSADLPATTTTTTDTTTTTDSSSSSGSSSSSASQSSSRSSAKGKPTTAASAAPAITAPKPALKGKAKASAAEILFRDDEIVDVNSSSSSSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1A7</accession>
    <name>A0A0D2U1A7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1A7"/>
    <dbReference type="STRING" id="595528.A0A0D2U1A7"/>
    <dbReference type="eggNOG" id="KOG1665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1A7"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18376">
        <property type="entry name" value="BTB_POZ_FIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="366"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="581" mass="61590" checksum="C2A8747CCDABF9C2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2Y0</accession>
    <name>A0A0D2U2Y0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2Y0"/>
    <dbReference type="InParanoid" id="A0A0D2U2Y0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="107" mass="12348" checksum="D90947F2227346F8" modified="2015-04-29" version="1">MIRDSEKEIKLFDVIASAFRQDLMTRKSETKKTRKKKSYALVAPSLPPFSFLPSNTCSFSIAFLSRTMGKSQSLRAMDWNFMQIFFVDRFAAFGWIALLPPCAQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U397</accession>
    <name>A0A0D2U397_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365948.2">
        <property type="nucleotide sequence ID" value="XM_004365891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U397"/>
    <dbReference type="STRING" id="595528.A0A0D2U397"/>
    <dbReference type="eggNOG" id="KOG3865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U397"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U397"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="209"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="50479" checksum="1A71EC5136FDE56E" modified="2015-04-29" version="1">MSNGGAAAGAKSSSNTRRVFKKQSYDEQLTLYIPTREFVDAGAHVDVVDAVVLIDDIVRKNKEKKVFVKLTGCFRYGNNDWDVLGVGFEKALYEVTVPVYPPPEKYERITKFQERMCKKLGRNSFPATLSFRPNLPSSVQLLTIGQEEKKKSSNGVVDNCGVFYDVIAYVAKDVAEAPNKKHAARFAIKKVPHTPASADGVSISKIVVEKKDPNVEVALSRHLYYHGEPIEVELAIANTSRDIKSIEIRLIQLLTLQMADAPKSWKYKNKLTFLESTADCPIVKGTTYKRTFTLQPIIPNAQDKKEVRHVAIDSTETGEDPKLAATTRLTHSGADTNAGLIVNYYVHVTLHRALGNIKAKVPFTLSHHERPKPSKASAAASLKSSSASHQVSASSSQSGASTSAAASALLQPPDNSSSHSGGATEYMSGADLDDLGDWDEEDSKLSEEFAKFISDRAKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3L9</accession>
    <name>A0A0D2U3L9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349756.1">
        <property type="nucleotide sequence ID" value="XM_004349706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3L9"/>
    <dbReference type="FunCoup" id="A0A0D2U3L9">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3L9"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3L9"/>
    <dbReference type="OMA" id="PNSSFWY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3L9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="598"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="699" mass="75073" checksum="6B8740A3E1244948" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U421</accession>
    <name>A0A0D2U421_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349851.1">
        <property type="nucleotide sequence ID" value="XM_004349801.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U421"/>
    <dbReference type="FunCoup" id="A0A0D2U421">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U421"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U421"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U421"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="16102" checksum="9A4ADA31F5154855" modified="2015-04-29" version="1">MVVFGVYVINKAGGLIYGQELGATPKLRANDRLTLASMFHSLYAITSNLSPQVQSSGIEVIETDTFKIQCKQTLTGTKFFVMSDPAHTGLDALLRRLYELYSDYVLKNPFYTPEMPIRCELFDINLARLMEQYESGRALTATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7Z8</accession>
    <name>A0A0D2U7Z8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor ISY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7Z8"/>
    <dbReference type="FunCoup" id="A0A0D2U7Z8">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U7Z8"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7Z8"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7Z8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="285" mass="32283" checksum="42DC265367207134" modified="2015-04-29" version="1">MHKRPARNEEKAQSMLNRFRALQQAELKGPKPKRPFYATDCNSIGEAEKWRLEVMSEVSKKVSQIQNAALGEFKLRDLNDEINKLLREKRHWQDRIIELGGKDYFKIGPRMLDHEGKEVPGARGYKYFGAAKDLPGVRELFAAATTQTTRRTRAELHKDVDADYYGYRDDDDGTLIPLEQEAEAQAIAEAVQQWEAKNNQRATAMAIDNEDDDDNDDTNIYKQAVASGSMFGKAGAEDDELDGALDSRKPEVFVAHVAVPTQADVEKLLVERKKQELLQRFAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U899</accession>
    <name>A0A0D2U899_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2U899">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U899"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U899"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U899"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1320"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1390"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1426"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1556"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="296"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1582" mass="176766" checksum="F8C0B05EF36E26AC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDL1</accession>
    <name>A0A0D2UDL1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDL1"/>
    <dbReference type="InParanoid" id="A0A0D2UDL1"/>
    <dbReference type="OrthoDB" id="2137924at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1213" mass="132674" checksum="34338A938BA42030" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE77</accession>
    <name>A0A0D2UE77_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proliferation-associated 2G4,b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348044.1">
        <property type="nucleotide sequence ID" value="XM_004347994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE77"/>
    <dbReference type="FunCoup" id="A0A0D2UE77">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UE77"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE77"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE77"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000013">
        <property type="entry name" value="DNA-binding protein, 42 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="395" mass="42281" checksum="58A3FECCA4C43AF0" modified="2015-04-29" version="1">MSTAAQIEEEEGDFTLDNPDTVTKYRTAGDIANRVIKKVLAAAVPGATVLALCKLGDGEINEEVAKIYKANKKVKKGIAFPTCVSLNSTVCHQSPLSSDAAITLQAGDVAKVDLGVHVDGLIAVVAHTIVVGATKEAPVTGRKADVLLAAYNASEAAVRLVQAGSTNHKVTETVQQVAQQFKCNTVEGMLSHQLERNIIDGKKTIILNPNEAQRKEHKELTFEIGEVYGVDVIVSTAEGKSRTLDTRTTVYKKTDAVYLLKMQASRTFLSQAKEKYGNFPFSIRSFDDENKAKIGVLECTKHNVMTPFSVLYDRDDTASVAQFKFTVLLTKNGPIRITSVPFEAELFKSEHSVVDAELKALLASSAKGKSKAKKADAAAPEAASSSSAPAPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFM4</accession>
    <name>A0A0D2UFM4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347397.1">
        <property type="nucleotide sequence ID" value="XM_004347347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFM4"/>
    <dbReference type="FunCoup" id="A0A0D2UFM4">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UFM4"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFM4"/>
    <dbReference type="OMA" id="ACWRITR"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFM4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="7">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="523" mass="57214" checksum="214414BA1235771F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL44</accession>
    <name>A0A0D2UL44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344976.1">
        <property type="nucleotide sequence ID" value="XM_004344926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL44"/>
    <dbReference type="STRING" id="595528.A0A0D2UL44"/>
    <dbReference type="InParanoid" id="A0A0D2UL44"/>
    <dbReference type="OMA" id="RNNIMAN"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="711" mass="74632" checksum="8FB2D80157590C12" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULC0</accession>
    <name>A0A0D2ULC0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULC0"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULC0"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="117" mass="13209" checksum="41925961C110203E" modified="2015-04-29" version="1">MGSTLHPVSLVYYGAHFSDLITFTPLVIGKFFIRYGVGCAMLFLTRLIFKTLMTRVFTYLLTSSGSLKGVPTVTRDRERPYGGYVIEIPTKFVTYSMVGFMATFAMPAFFRYIGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQQ1</accession>
    <name>A0A0D2UQQ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343086.1">
        <property type="nucleotide sequence ID" value="XM_004343036.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQQ1"/>
    <dbReference type="InParanoid" id="A0A0D2UQQ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="253" mass="28250" checksum="4115D8AF249E4ACD" modified="2015-04-29" version="1">MSQLHSVVTQTTKLTLPARVSLARRLLEQSTAIYLPRLCLEFLWSVLVDIEVPARKRQTAASIMQPSESTESSDSLGSLTNKLKLFVDNTVAMDAIRDALLALKTPSSPSSPKRPQRNILVLALSTWEKWHEDVVSTVAASSARDLVIEQMTSLNDPIDEDARPTDAAFKNAYTLLQKLDDRHFPHMPMIESNGQRGVMLVWETISATITFVDQGEVVVSMLRKPKPWLAAMNSTPEVFGKLVRELFEQTTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFH3</accession>
    <name>A0A0D2VFH3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Calcium-binding carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFH3"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFH3"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFH3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="373"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="471"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="568"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="705" mass="76971" checksum="2025AA2DCFC989CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFY7</accession>
    <name>A0A0D2VFY7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365159.1">
        <property type="nucleotide sequence ID" value="XM_004365102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFY7"/>
    <dbReference type="STRING" id="595528.A0A0D2VFY7"/>
    <dbReference type="eggNOG" id="ENOG502S6V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFY7"/>
    <dbReference type="OMA" id="DEKAMVC"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="131" mass="14733" checksum="5EBEF4DFFB0C4FEC" modified="2015-04-29" version="1">MANVQNLLSDLARVEALAEEVLDGKQEMVELDRKRQSCREAVNGIKAIPPSEGSKLWMAIGPLFLRVQKDKAIGMIQKDRDNIDKQLELTRQDVKFKTAQLYELQNKPHLASGYLLNSLSSEDANVLRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG21</accession>
    <name>A0A0D2VG21_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365211.1">
        <property type="nucleotide sequence ID" value="XM_004365154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG21"/>
    <dbReference type="STRING" id="595528.A0A0D2VG21"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG21"/>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="47434" checksum="B7602A9666EDB6CD" modified="2015-04-29" version="1">MSVPALEPIELGFAEQVDNPVFLTSPYFPSKIGGHPAWLNPQHLPSTESAAADGLACPLCTKPMAFLLQLYTPVDDSPACFHRSVYVFCCRNGGCHKTASATGAHCFKVLRCQLPRENPYFGVDANDNVELDSSVQGQRRVALSAPTCAVCGNLGPKKCGQCGRARYCSREHQVAHWGAGHKQACSNASGNVAPTAKEVALRFPEFELVTEPEEVRPGDDGDEDDEAAEKRRMQEFEAAVKDFKLDVQTEEEGKDVDDLFDGSDTVQEEDECFEAFQKRVARDSEQVLRYQKGGKPLWISDVAQCAPGAVPRCLNCGTQRVFEFQIMPQLLWILGVDNLDGNSLDWGTLLVYTCPNDCNPQEASATTPAQPATEPASFASVAATNAKPVPVTSSAYLPEFLYSQQVSEKGSIDLQQRERRAPQPDARPEATNASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIA7</accession>
    <name>A0A0D2VIA7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270048.1">
        <property type="nucleotide sequence ID" value="XM_011271746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIA7"/>
    <dbReference type="FunCoup" id="A0A0D2VIA7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIA7"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIA7"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="330"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="361"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="695" mass="76885" checksum="808096EB7A8A0674" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VII5</accession>
    <name>A0A0D2VII5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VII5"/>
    <dbReference type="STRING" id="595528.A0A0D2VII5"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VII5"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VII5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63600" checksum="F0BC546ACB34C67F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL42</accession>
    <name>A0A0D2VL42_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348811.1">
        <property type="nucleotide sequence ID" value="XM_004348761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL42"/>
    <dbReference type="STRING" id="595528.A0A0D2VL42"/>
    <dbReference type="eggNOG" id="ENOG502TGJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL42"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="322" mass="33912" checksum="3A68DD13203C2044" modified="2015-04-29" version="1">MAAHLARAARLKILAASACTRRRASEAASRVPLTARLSPLPLLSKHTTTTAAAASASHRQQPTPTIATATAAAAAAAAASMSMQVPSTQSPHAAAHLHNVVVGSAELMPNLPRSSGDVQIIPKLTAVNPMLPMHVGLPTLGLSSAAAMSLMMPGVQSYVQQQALWMFFLQQQHQQQQQQQQQQQQQQQYFQLRHIQQQLFLNRLSSHTATGAGVAPVFATGAADPITPGVFDDLDSYELLGNVSELSTDLAGFAHNPSSSDASSPTASSVSEHHDWDSLSTSASNSPLLTPNMHSAQQVQSDADMLQLKTLPLGLASSAVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMB0</accession>
    <name>A0A0D2VMB0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_009545</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMB0"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMB0"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMB0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1730"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1213"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1312"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1519"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1627"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1870"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1760"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1760"/>
            <end position="1770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2171" mass="231327" checksum="86D5364450BE3640" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN83</accession>
    <name>A0A0D2VN83_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_002822</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348635.1">
        <property type="nucleotide sequence ID" value="XM_004348585.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN83"/>
    <dbReference type="FunCoup" id="A0A0D2VN83">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VN83"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN83"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE91727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="512" mass="55700" checksum="A9534AD884361895" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQI2</accession>
    <name>A0A0D2VQI2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363537.1">
        <property type="nucleotide sequence ID" value="XM_004363480.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQI2"/>
    <dbReference type="FunCoup" id="A0A0D2VQI2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQI2"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQI2"/>
    <dbReference type="OMA" id="NCECTHA"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58047" checksum="580CCE6AF2C9D5E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQP5</accession>
    <name>A0A0D2VQP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidinol-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363612.1">
        <property type="nucleotide sequence ID" value="XM_004363555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQP5"/>
    <dbReference type="FunCoup" id="A0A0D2VQP5">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQP5"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQP5"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQP5"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="305" mass="34165" checksum="12C9D84C6496FEAE" modified="2015-04-29" version="1">MPFTYHSHSGQFCLHAAGTLEAVVLRAIDAGFTHIGLSEHMPRTRESQLYNEEKHLAPAALDDMFTAYIAEARRLRDKYGSRIHIVIGMETEYFGSETIAEIRALVARHEIEYLVGSVHHVHGIPTDYSSALCNDAETAAGGSSDQLFQAYFEHQYALINALQPQVVGHFDVIRLYRRDAPLSAATWELIDRNIRCAVSYGALFEINSRALKKMFAHPYPQLDIAQRILSLGGKFTICDDSHGENDVAMHYDQLPSYLELLNIDTVYLLERVKDAATGAVTTVTRPVDWRTHPYWSAKAKAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQY4</accession>
    <name>A0A0D2VQY4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQY4"/>
    <dbReference type="InParanoid" id="A0A0D2VQY4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="108" mass="10381" checksum="A453D910E0A41FDF" modified="2015-04-29" version="1">MMATSALATPTPALAPSLHAAGAAPTALPAANTSTGSSAGGSSSSSGNGRGATRRRNPQDASASASASASSSASAASSGARRNPKASCCSQCSCKRRCSTLPCFALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRC1</accession>
    <name>A0A0D2VRC1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein LST8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348021.1">
        <property type="nucleotide sequence ID" value="XM_004347971.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRC1"/>
    <dbReference type="FunCoup" id="A0A0D2VRC1">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRC1"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRC1"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRC1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000505">
        <property type="entry name" value="Blast:Protein LST8 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="38946" checksum="707EE1797B6C5649" modified="2015-04-29" version="1">MAAPNHQQFFQQTQQQQQYQQYQQQQQYLQQQQHHAQASMDPSANSVILVTAGYDHTIRFWEALSGVCYRTVQHPDAQVNCLAITPDKQYIAAGGNPHIRMYDIASHNHNPITSFDGHTGNVTAVGFRADGKWMYSGSEDTTIKIWDMRTPGCQREYVAGSAVNCVTLHPNQTELISGDQSGRIKIWELRTNKCAEDLIPEPDVPIRSLTIAPDASQLVAGNNNGNCYVWKLQHHANEPTTATPIKHLAAHSSHVLKCLISPDARLLATCSSELESSVKIWNIQANYSLFKTLSGHQRWVWDCAFSSDSAYLVTASSDQIARLWDIAQGESIKQFTGHLKAITCLALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRK7</accession>
    <name>A0A0D2VRK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium-dependent cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348120.1">
        <property type="nucleotide sequence ID" value="XM_004348070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRK7"/>
    <dbReference type="STRING" id="595528.A0A0D2VRK7"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRK7"/>
    <dbReference type="OMA" id="KSPKTKW"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="94"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="256" mass="28510" checksum="7E3197538FD54533" modified="2015-04-29" version="1">MTEPQFESLENFRITKAPPSVLYVPNFITDNEASYFWDQVHAAPKVKWTALKDRRLQNWGGTQTAKGMIAEPLPRWLQLLAERMHTTGVFGSLVPNHVLVNEYLPGQGIMPHEDGPFFSPVITTINLGSHCVIKFYRPRDSDIVSETANGREGSDSDNPATTNSRHSLESRRVTSLFLEPNSLLVLREDMYTRFLHGIEPVPQDSLAEVRATCANAAQCPSLAAASDDVLARSTRVSLTIRHAPNTIKLKFKLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUU1</accession>
    <name>A0A0D2VUU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346298.2">
        <property type="nucleotide sequence ID" value="XM_004346248.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUU1"/>
    <dbReference type="FunCoup" id="A0A0D2VUU1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VUU1"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUU1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="227" mass="24511" checksum="2B4A19496411B84E" modified="2015-04-29" version="1">MANAAVACVLFDLDGTLLDTEPLSDIAMQGVLDRFGKTMSWELKRKILGLKGSDWSVIVVDHFGLHGLIEPAAIVDGWETNFKQLYSRAQKLPGADRITAHLAQLGIPMAICTSSNSAAVELKRAAHPEMFARCTLVVTGDDPELKNGKPSPDIFLLAAKRLGMRPEQCLVFEDALSGCQAGVAAGMRTIVIPDTRLDRQPFEIATEILTSLESFQPAVYGLAPFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV56</accession>
    <name>A0A0D2VV56_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346455.1">
        <property type="nucleotide sequence ID" value="XM_004346405.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV56"/>
    <dbReference type="STRING" id="595528.A0A0D2VV56"/>
    <dbReference type="InParanoid" id="A0A0D2VV56"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="247" mass="25639" checksum="FFDDAC2899E51A0D" modified="2015-04-29" version="1">MSRGNSNVVKCGLTQTTYGEQPDWAFSEKGKAKHYQHNDAVPGVQRTGDWSSNSRSSAPPLKSVTRSSPSAASANLSNGQPRYGAPVDDLRAANSRPSASSSSFSSSSSSSSSSSQPKYGGPVSSSSSSSQPKYGGPVSSSSSSSSSSSWSTSNSAARTGATPRAVSPTRAGRPSVNAVSSGYARSSEQSSFQRDTDASGRSDVVECGLSKTTYEKQPAWAFAEQQKNQSGRYQVGKNTSTAGKSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWB1</accession>
    <name>A0A0D2VWB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344990.1">
        <property type="nucleotide sequence ID" value="XM_004344940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWB1"/>
    <dbReference type="InParanoid" id="A0A0D2VWB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="708" mass="76741" checksum="A3500E3930CE3225" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWG1</accession>
    <name>A0A0D2VWG1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345059.1">
        <property type="nucleotide sequence ID" value="XM_004345009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWG1"/>
    <dbReference type="STRING" id="595528.A0A0D2VWG1"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWG1"/>
    <dbReference type="OMA" id="PANACAQ"/>
    <dbReference type="OrthoDB" id="1840988at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="343"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="635" mass="67013" checksum="FD63FD2D8906CF76" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYJ3</accession>
    <name>A0A0D2VYJ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270723.1">
        <property type="nucleotide sequence ID" value="XM_011272421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYJ3"/>
    <dbReference type="STRING" id="595528.A0A0D2VYJ3"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYJ3"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="348"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="684" mass="73444" checksum="2A633BC365CF8CBA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W158</accession>
    <name>A0A0D2W158_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342657.1">
        <property type="nucleotide sequence ID" value="XM_004342608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W158"/>
    <dbReference type="FunCoup" id="A0A0D2W158">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W158"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W158"/>
    <dbReference type="OMA" id="GMFQKEV"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W158"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000002">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="35464" checksum="2D7564D252557939" modified="2015-04-29" version="1">MPKIRAESTSRRTRDETAKAASTVSQAIQFDKSFGQHILKNPLIVNGIIEKAGLRNTDTVLEIGPGTGNLTMKLLEASKKVVACEVDVRLVAELQKRVMGTPYQRNLEILVGDVLKADLPFFDVCVANMPYQISSPFVFKLLLHRPFFRCAVLMFQKEFAQRLYAKPGDPAYCRLSVNTQLLARVDHLMKVGRNNFRPPPQVESAVVRIEPRNPPPPINFQEWDGLVRITFVRKNKTLHAAFMSSAVLEMLDRNYRTFCALNNTELPEGFEIKPLVEQILEASGFSEKRARLMDTDDFLRLLEAFNNEGVHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1F5</accession>
    <name>A0A0D2W1F5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342727.1">
        <property type="nucleotide sequence ID" value="XM_004342678.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W1F5"/>
    <dbReference type="eggNOG" id="ENOG502S7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1F5"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1F5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="534"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE98107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1593" mass="172928" checksum="14EFF0986A130AA5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WG65</accession>
    <name>A0A0D2WG65_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364880.1">
        <property type="nucleotide sequence ID" value="XM_004364823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WG65"/>
    <dbReference type="STRING" id="595528.A0A0D2WG65"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WG65"/>
    <dbReference type="OMA" id="TAMAVEC"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WG65"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="276"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="398" mass="41231" checksum="B84931F2DCDB7BA1" modified="2015-04-29" version="1">MTYADSDVVIVAAARTPIGSFNGALSTVPASELGRVVISEVLRRAGNVAPSDVSEVILGQVLTAAAGQNPARQAARAADIPIETPAYGINMLCGSGLRAVALGYQAIRAGDSRIVIAGGQESMSQAPHAMHLRAGVKMGDASMVDTMMKDGLVDAFHGYPMGITAENIAKRDCISREQQDEFALQSQLKTEKATNAGIWKEEIVPVTIKSRAGDKVVDTDEFPRKGATIDSLKKLRPAFISDGTGTVTAGNASGINDGAAAVVLMTAAEARQRGVEILGRIVSWAQAGVDPAVMGTGPIPAIRSALAKASWAVNDVDFYECNEAFAAQSIAVVSHLQLPVEKVNVNGGALALGHPIGASGARVLVTLVHQLRRTSAKKGVAALCIGGGMGIAMCVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHP9</accession>
    <name>A0A0D2WHP9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHP9"/>
    <dbReference type="InParanoid" id="A0A0D2WHP9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="66" mass="6620" checksum="C1D8C3C3117D6896" modified="2015-04-29" version="1">MASTTERAVVDTPAPAANRLTIEEASSSHVMHPIRLSILICGTSSASSEAGTGSVQPPSPATSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHQ9</accession>
    <name>A0A0D2WHQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365581.2">
        <property type="nucleotide sequence ID" value="XM_004365524.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHQ9"/>
    <dbReference type="FunCoup" id="A0A0D2WHQ9">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHQ9"/>
    <dbReference type="InParanoid" id="A0A0D2WHQ9"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="136"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="552" mass="61832" checksum="C2613BE0B56D1701" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI74</accession>
    <name>A0A0D2WI74_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI74"/>
    <dbReference type="STRING" id="595528.A0A0D2WI74"/>
    <dbReference type="eggNOG" id="KOG4317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI74"/>
    <dbReference type="OrthoDB" id="10005492at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="60561" checksum="EF48FE7515E7CB00" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIC6</accession>
    <name>A0A0D2WIC6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365189.1">
        <property type="nucleotide sequence ID" value="XM_004365132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIC6"/>
    <dbReference type="STRING" id="595528.A0A0D2WIC6"/>
    <dbReference type="eggNOG" id="ENOG502QR0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIC6"/>
    <dbReference type="OMA" id="HQPDPKC"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIC6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="212"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40747" checksum="6C8B571C9FB5A35B" modified="2015-04-29" version="1">MEVPVINLAPFMSDATSAEAAAECAKAAKALEEFGCLVVRDPRVTEADNSTFLDLMEQYFEQSVEDKKADERPQWGYQVGVTPELVEVPRCTVDPKCLDTIAKMPEDERAHVPVGPDPKWRFFWRLGERPSETKFKELNAEPVVPKAFPQWGQVMNKWGSLMMDAVTSLSEMVAVGFDMPSDIFTKLAKNGPHLLAPTGSDLARYHEKNTIFAGFHTDLNFLTIHGKSRFPGLYVWRRDGKRVDVRVPDGCLLVQAGKQLEWLTGGRVIAGYHEVIVTDRTLEAIERAKAAHRSLWRISSTVFMHIASDNILRPLTEYGFQENAELYPHMLTGDQVARELSALQLKKIDNINQANAAAAAGQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ04</accession>
    <name>A0A0D2WJ04_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365553.1">
        <property type="nucleotide sequence ID" value="XM_004365496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ04"/>
    <dbReference type="InParanoid" id="A0A0D2WJ04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1090" mass="115305" checksum="6EDAAB2F2FA17A91" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJC3</accession>
    <name>A0A0D2WJC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365793.1">
        <property type="nucleotide sequence ID" value="XM_004365736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJC3"/>
    <dbReference type="FunCoup" id="A0A0D2WJC3">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJC3"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJC3"/>
    <dbReference type="OMA" id="RATENEC"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJC3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000207">
        <property type="entry name" value="serine/threonine-protein kinase dst1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="510" mass="55260" checksum="77D6DCB8DEF77A77" modified="2015-04-29" version="1">MASGLMKIDPEQLYERQERIGKGSFGEVFKGIERTSRMPVAIKIIDLEAAEDDIEDIQQEIAHLSQCDSAYVTRYFGSYCKGPQLWIIMEYLGGGSVLTLLKPGPIDEVHIAIIMREMLFGLDYLHQNGKIHRDIKAANVLLSSDGQVKLADFGVSGQLTSTMSKRNTFVGTPFWMAPEVIKQSGYDCKADIWSLGISAIEMAKAEPPHANIHPMKVLFIIPKDPAPVLHGMFTKAFKEFVALCLNKNAAERPSARELLKHRFIVRAKRTQYLQELVERYQQWVAVQGEQDHGDSTNASSAATVDADEEAWIYETVKTMKHQRKAALQRQDSDSTMLGDDSLAGGLPRPSGTDKSSIYSTINSRTENPTLSGASANTTGSAASGTPSNTSDAVDVKTSSLSALSGLLLPSIEALKGESTEGNKALVLLAEALQRAEAAQPGVALSLVDRIADQAAGVTLRRNGVVTPSTAPSGTFATTSGSTAANVRGTAEYLFARWMNKCVEVDGKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJQ6</accession>
    <name>A0A0D2WJQ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJQ6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJQ6"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJQ6"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="275"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="35779" checksum="A1A5C9070EC4125D" modified="2015-04-29" version="1">MKRIANRPQPFEQIALEADTLPLGELSPPMLVPATAYMDFECGTSPWMVIPITDNAVAANESKTAVVDGLTRVATAPAPVAAAGGCPSKRQEPSVEPMVVADASTSGTDADDETPPGPPGAWKSSTCYHDFYHETISQEDWAAFWATVNQPLPSSFRINASNPSIAQTTSATLSQRCQQLRSMLEQEKADSARMLRDLPQPISWYPLHPEVSEEPLAWRLALSTRGLASSVQHEPLRHFLMNAATDGAIVRQEEVSMIPPLLLQVESHHAVLDMCAAPGSKTTEVLDLLLQHHHQTSATSPNVPSIPTGFVLANDADCESPSSPSFNRPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK48</accession>
    <name>A0A0D2WK48_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK48"/>
    <dbReference type="FunCoup" id="A0A0D2WK48">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK48"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK48"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK48"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="232" mass="26597" checksum="7E7B3154A2828B59" modified="2015-04-29" version="1">MVSLRLQKRLAASVLKCGKRKIWLDPNEVVTISNANSRQNVRKLVKDGLIVKLPQTVHSRSRAREHLLSKQKGRHMGHGRRKGTRDARMPQKIIWIRRMRVLRRLLRKYREGKKIDKHLYHELYMNAKGNVFKNKRVLMEFIHKRKAEKARTKIIVDQAEARRARTKAARNRREERLAKIQVVPAEESKTEKKAEKKTAKQTEKAAPAKAAPVAAAAPAAAAPAKKAAPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKC9</accession>
    <name>A0A0D2WKC9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fts-prov protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364818.1">
        <property type="nucleotide sequence ID" value="XM_004364761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKC9"/>
    <dbReference type="STRING" id="595528.A0A0D2WKC9"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKC9"/>
    <dbReference type="OMA" id="WGFPEWR"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="230" mass="26310" checksum="5AD3450968E07D7D" modified="2015-04-29" version="1">MSGPAESSAAASAPAGNAPVLEAFAPYFRQYALLTEFKRFAAQYISGVLCVPSSKNSDVWDGVIFVRKGQYAGGIFKFYIHFPATYPMGTEPPRIVFQRPLFHPLVHPQSNELDVTRKFPTWRKNEDHIWDMLLYLKRCFYKIETDDPANPDAAALLLNDERMFQQRVDNCVSDSKMHVHSKDESEIQFCDWKDEYDAELKHYWETGSFEGPRVLSHSNPTGDSARVYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKJ3</accession>
    <name>A0A0D2WKJ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348808.1">
        <property type="nucleotide sequence ID" value="XM_004348758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKJ3"/>
    <dbReference type="FunCoup" id="A0A0D2WKJ3">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKJ3"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKJ3"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19123">
        <property type="entry name" value="AKR_AKR3G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044496">
        <property type="entry name" value="AKR3G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="314" mass="34325" checksum="5F3125BDFD9D5134" modified="2015-04-29" version="1">MSAVKQFILSTGATIPAIGFGTWRASPGEAGEAVKRALEAGYRHIDCAAFYGNEAEIGATAFAPLFQSGKIARKDVFVTSKLWNTEHDPKDVRPALIKTLADLQLDYLDLYLMHWPVALQRGAIRDADGNLLDLPIPLADTWRAMEQLYDEGLVKAIGVSNFTSVKIDKLLTTARVAPVVNQVEISPYLQQRKLVAYCEGKGIHVTGYATLGSGQTPRALDDPIIGQIAAKHNVSAAQVMINWCAYVNNCSVIPKSTNPERIQANFNSKDVKLDASDIATLQSLDRGLRLFPGKGFWRKGETADEFWDGFGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKU3</accession>
    <name>A0A0D2WKU3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348950.1">
        <property type="nucleotide sequence ID" value="XM_004348900.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WKU3">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKU3"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKU3"/>
    <dbReference type="OMA" id="SHTWIDQ"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="738"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="944"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1320" mass="144787" checksum="24E63445A269687F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WME8</accession>
    <name>A0A0D2WME8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Efflux ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363871.1">
        <property type="nucleotide sequence ID" value="XM_004363814.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WME8"/>
    <dbReference type="STRING" id="595528.A0A0D2WME8"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WME8"/>
    <dbReference type="OMA" id="RAAYCHE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WME8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18557">
        <property type="entry name" value="ABC_6TM_TAP_ABCB8_10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="166"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="558"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="797" mass="86435" checksum="A71EE0B170BE2386" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNE0</accession>
    <name>A0A0D2WNE0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008713</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270333.1">
        <property type="nucleotide sequence ID" value="XM_011272031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNE0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNE0"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNE0"/>
    <dbReference type="OMA" id="MRREWFV"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="19986" checksum="AEE196514A8C4378" modified="2015-04-29" version="1">MGLTISSLLTRLWSTAEMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVESVEYKNVNFNVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERITEAAAELQKMLDEPELQNAVVLVFANKQDLPNAMTTSMVTEKLGLDKLTCKWSVRAACAQSGEGLYEGLDWLSAQLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNH8</accession>
    <name>A0A0D2WNH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363842.2">
        <property type="nucleotide sequence ID" value="XM_004363785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNH8"/>
    <dbReference type="STRING" id="595528.A0A0D2WNH8"/>
    <dbReference type="eggNOG" id="ENOG502S9Q0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254507" evidence="1">
        <location>
            <begin position="34"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="31996" checksum="C75C83CC405DCF58" modified="2015-04-29" version="1">MRLHKKRSSLVMLATLAVAVLLLCGARNGPVSAGPGLFGLPSLIGADAQQVICPRCTFVNETVNWQILPRLAPFTLASGDGAPSQDTAVRLCHDTNALHVRFDATDIDIINNYTTCNSDIWNLETVEFFVAPGPETPTVYHELDQSPNPGAYFASLIHNPNDKCAGIVGNLMSCPTVGVSWATGRVSNGWWATIVADFDVLVNLTGDARGWHSDPRQFGEQLSVLNPPVDNEPVEVPILFEREGRAPIPKVWRANFYRIDAHANGTIEYSCLHSTLTNPACFHVPSRMVGLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNL0</accession>
    <name>A0A0D2WNL0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNL0"/>
    <dbReference type="STRING" id="595528.A0A0D2WNL0"/>
    <dbReference type="InParanoid" id="A0A0D2WNL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="345" mass="36972" checksum="489BC5EBC1E93E95" modified="2015-04-29" version="1">MSDPSAMLKSMLNLGGNSAPQPQQQHPPQQYDHQHHHQHHHQHQGQYDQQHQQHQHPFALQQQQQQYYGQMPLQQQPHHPFAAFTPHNQPLQPMQPMQPMQQHQQFQQQFHQQQQQQQQPAALLSPTHFGVNSASATTTTNSNTQEANAYESTFPAPAAAAAAAAEQQSNPLRNFFPPPPAAHAPQPSSSSSAAATSPAALAVVSPPPIGSPVAASSLSSSSTLAAAAAAPAQSFLNAPAITSVVHGQATGASDGGETDVEQDAWILPAELGPAIAIDRAQFGSRAAMIQASNKIKAETVTFYPSELTFSTGHLVAANEEFMAVCVEDEGASKRCCGCSLRLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP13</accession>
    <name>A0A0D2WP13_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363615.1">
        <property type="nucleotide sequence ID" value="XM_004363558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP13"/>
    <dbReference type="FunCoup" id="A0A0D2WP13">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WP13"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP13"/>
    <dbReference type="OMA" id="HAYKAIS"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="722" mass="75896" checksum="52E60B2A2C758EE6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP75</accession>
    <name>A0A0D2WP75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363661.1">
        <property type="nucleotide sequence ID" value="XM_004363604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP75"/>
    <dbReference type="eggNOG" id="KOG0648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP75"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000015">
        <property type="entry name" value="Nudix hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="482" mass="52843" checksum="EB14EB0C558464B7" modified="2015-04-29" version="1">MASVLNGLEDRYKGVTIDTEFAAELANNADQARFKTLLTDSLTAWRREGKRGIWLRIALKDAHYIPIAAEEGFVFHHAEPLHVMMTRWLPEDEPSQLPTYATHYVGVGGFVLNDQNELLVVSERYGDKPMWKLPGGHANRGEDLGQAAIREVFEETGIESEFISLTAFRHQHKYLFETSDLYFVCRLKALSLEIKHDPREISACRWLPLDQYIADPSVSYTNKHIATCIKLGLEKSDTTWEMTAAAVPSFNRKATNLLYCTKNADASQILCPEPVEGDESQANAAAAAAAGADNKTAPEWRRERRRSLRINMQMQAERLAKSSKRGDDDDIRSPEVAQDGNTSKPDIYSDPAIIAALAIAEAEEKGRKSPLPAPAPLSSNSSLDGLPTSVSPVSAFAHVQHASNLTRSRSRASSRANAKELVIDPARPTSFVVIVGGTGDGNASPRQRYSVHENLQQSQQLSSAGSSTASLDACTLPTISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPS2</accession>
    <name>A0A0D2WPS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin pyrophosphokinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348092.2">
        <property type="nucleotide sequence ID" value="XM_004348042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPS2"/>
    <dbReference type="STRING" id="595528.A0A0D2WPS2"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPS2"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="6">
        <location>
            <begin position="276"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="362" mass="38142" checksum="53EEBCB357BAB75B" modified="2015-04-29" version="1">MDWFPLIYSLTPAERNDLLLANGTADDCGAAAAVAGRVIRKPNRKTALVILNQPLIPVSSSLFQQLWADSAVHVCADGGTNRLYDGVGFAQQQVADSAAAAAAVARPVAEATDAVNHSDTSDRIARSNPHPQSVGCAPSQQTISRDMYRPDVIVGDFDSIRTEVKTFYSSSPATTIVHSPSENYHDMDKAILCAVDLLSGVSPRPLGSAGSALVLDDVQFDKAALAGASIVVLGGLGGRFDHTMACISSMLRWTNAVGATVTVITPECTVTMLPAGRHNIVANLQAEGPTCGLLPVCEPCMLTTSGFTWNLENGRIAYGELVSSSNSIDTTTVDARHPSLALLTVQTSAPLTWTTELHFAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPY5</accession>
    <name>A0A0D2WPY5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003780</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363508.1">
        <property type="nucleotide sequence ID" value="XM_004363451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPY5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPY5"/>
    <dbReference type="eggNOG" id="KOG1413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPY5"/>
    <dbReference type="OMA" id="KGYDLSW"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPY5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="453" mass="51512" checksum="AD02BBA9E8A99180" modified="2015-04-29" version="1">MRKVVLVPTALLAAAVIGFFIWNFLLLSSHLAGSAGETRMATLLEQVENSQQQIIAQQQQIQQLMERDANRQAAPCVQHQSEGTKADRRDDPPVPTLEDNNNTPAVVGKQTVHSAGEPIAVLVIACNRPDMVRCVDRLLKFRPSERFPIIISQDCGDASTAATIREHYGNQVIHVMQPELEEIPEAKHQPQFKGYYKISRHYKWALTQVFDVLFFNSVIIVEDDLEISEDFFDYFAAGRQLMEQDETLWCVSAWNDNGKSEFVSSAKKLYRTDFFPGLGWMLTRGVWSELSSKWPKAFWDDWMREPAQRANRACIRPDISRVSNFGERGVSAGQFFYDHIAKIKRPTETVPFLSMDLSYLLKDKYDPAYRAAVKAARTVRFEELLNSVPPGTGNLRVEYTSNQDFERKSSELGLMSDLKAGVPRTGYMGIVEFMYKGNRVYLSPPSDWSGYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPY7</accession>
    <name>A0A0D2WPY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPY7"/>
    <dbReference type="STRING" id="595528.A0A0D2WPY7"/>
    <dbReference type="eggNOG" id="ENOG502QYDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPY7"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="244"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121541" checksum="3B43F428E0F5B301" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQK1</accession>
    <name>A0A0D2WQK1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347426.1">
        <property type="nucleotide sequence ID" value="XM_004347376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQK1"/>
    <dbReference type="STRING" id="595528.A0A0D2WQK1"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQK1"/>
    <dbReference type="OMA" id="HATDTQS"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266507" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="167"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="525" mass="58801" checksum="8732DE0922E107A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQY2</accession>
    <name>A0A0D2WQY2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQY2"/>
    <dbReference type="STRING" id="595528.A0A0D2WQY2"/>
    <dbReference type="InParanoid" id="A0A0D2WQY2"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQY2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF161">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266516" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="76704" checksum="CBBFB2715792E9E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRH9</accession>
    <name>A0A0D2WRH9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cystinosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347322.1">
        <property type="nucleotide sequence ID" value="XM_004347272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRH9"/>
    <dbReference type="STRING" id="595528.A0A0D2WRH9"/>
    <dbReference type="eggNOG" id="KOG3145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRH9"/>
    <dbReference type="OMA" id="WIDVIYT"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000022">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270130" evidence="12">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="389" mass="43439" checksum="5D791A5308549289" modified="2015-04-29" version="1">MVGKSLVAAMMLVACLASSVRGATLDIDVPDPVLSGDTFQIAIRPSQRPLSDVTVLLRSSNEAIVNIQTLTVTLPANSTAQVIAYASALGAGNPDLKFTMGGADPAFRGDLSLGISIVKNKPLSIVITVIGWIYFVAWSISFYPQVYENFRRKSVVGLNFDFLAYNITGFLCYSAFNIGLFWVTSIQDLYFADHPDGVNPVQANDVFFAIHAVVLTLVTIVQCFIYDRGEQRVSWISRIILIGAWLFAFISFWIAFKGIISWLTYLYYFSYIKLGITLIKYVPQAFMNFRRKSTVGWSIGNVLLDFTGGALSILQMFLLAYNSDDWSSIFGDPTKFGLGLFSVVFDVLFIIQHYCLYRHNREDPASYMYSPYPLNGDSQDRSRLLTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS60</accession>
    <name>A0A0D2WS60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347637.1">
        <property type="nucleotide sequence ID" value="XM_004347587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS60"/>
    <dbReference type="STRING" id="595528.A0A0D2WS60"/>
    <dbReference type="eggNOG" id="KOG4435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS60"/>
    <dbReference type="OrthoDB" id="9979394at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047620">
        <property type="term" value="F:acylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="126"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="641" mass="68876" checksum="7744F5F576A55009" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSG5</accession>
    <name>A0A0D2WSG5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346250.2">
        <property type="nucleotide sequence ID" value="XM_004346200.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSG5"/>
    <dbReference type="eggNOG" id="KOG2242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSG5"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="1847"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1377"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1463"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1391"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1515"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2129" mass="232653" checksum="F29AD1437F2EC2E1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSW0</accession>
    <name>A0A0D2WSW0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345454.2">
        <property type="nucleotide sequence ID" value="XM_004345404.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSW0"/>
    <dbReference type="InParanoid" id="A0A0D2WSW0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="119" mass="13569" checksum="2A4995029BACF1B2" modified="2015-04-29" version="1">MPLPSIRPRVMPQTPIQLYRFCLGLIRHMPPVFQRRTRAIVRDMIVINGRHARPQDVPRLVREGVDHMESFYLVFTAKPETILQLFYAENVLGSASAASSAPAFKQPDQGRPNETTPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTE2</accession>
    <name>A0A0D2WTE2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTE2"/>
    <dbReference type="FunCoup" id="A0A0D2WTE2">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTE2"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTE2"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="217"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="47813" checksum="A67C2D943060EB59" modified="2015-04-29" version="1">MATNEERAKYQRAFAESATRPVIVDHVHVDGLTFTNPETVTYASKAVFEAKTVAEALQAASASAVELQRLGIFKSIEVTVDAAPYQPPPQVHDPSSPQHIEVTFNVTESSRLAASSGTLIGNAEVDWETNATLRNALFGRAEKLSLNYAVGMRNKAAYMLDYIQPISGDPDRFIHSSSAHQRRPRSLHSQLGLPVMVYIACNTRLLNIPFRASMLVREQAGHSLLSSIKHVLTHDTRNDTHLATQGKLVEWTQEFAGIGGDAKFIKSHVQAQFNQAFFNENLIVSASLWGGLLSMLGGTESRISDRFFLGGPNSLRGFTVRGAGPHDKGAYLGGDAYVAGAAHVYSTMPFKFLRDTFGRSLLLHGFASAGNITQIAPDQFVVPRLLSLFQPGSMRYSVGAGVVFRSGMARLELNYCVPFSAAGTDNFRAGFQVGLGVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU06</accession>
    <name>A0A0D2WU06_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU06"/>
    <dbReference type="InParanoid" id="A0A0D2WU06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="74" mass="8066" checksum="FE4A292FB4D70AE5" modified="2015-04-29" version="1">MLTDHLRIPSRPSQADGLSGRDHTHPGGPSLTGAYVIELDLPISGKKRDRIAQGWPQGPMEAQPSQTAIRRHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU09</accession>
    <name>A0A0D2WU09_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345177.1">
        <property type="nucleotide sequence ID" value="XM_004345127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU09"/>
    <dbReference type="InParanoid" id="A0A0D2WU09"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="90" mass="10233" checksum="6E6FF8179ACDC9B8" modified="2015-04-29" version="1">MFINHGSHVELNRVLTWLNDPARELQEASQAVPDEHDDPDDLSDDGELSDDSDRSEEEIVATYHPKLRRSVTSRATEVLAFHQCDFLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU22</accession>
    <name>A0A0D2WU22_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346436.1">
        <property type="nucleotide sequence ID" value="XM_004346386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU22"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU22"/>
    <dbReference type="OMA" id="MQLRYHD"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="451" mass="48924" checksum="D6AC1E79100D6CE7" modified="2015-04-29" version="1">MSTTRKSFAQAASRTGRAPRELEVLVFGATGFTGTLVARYLAERLPAGSKWGIAGRDAAKLNKVKSELIALRGSCAEDVVVVDGVDVESELSIKAATARTWVLLNCVGPFIAYGIPVVRSCIETHTDYVDITGEPRFVSAVVEQFHQRATEADVLIVPCCGFDSIPADLGVWYTLQLPGCIDAATQTSRVQSVKTVIAARANLSNGTFTTAIEAVGMSQLSDLRQLMQAWYNSGSLSQFLFPPAANAPRFSIQYMRAVKDWVMPLPVIDTAIVRRSWELTPKASGSSTTNVASPYPSPFYYGQYYQMRGFKSVLKLVLFFPILLLLTVVARFPGGRAYLQRFGPKQRQGPSEERRKRSWFKSQVIAYDAKGAVLAQGVVSGGDPGYTETAKMLSECALLLAHHRYELPLRAGVATTASAFGNHLVSSLSAAGIKFEDVTGKDPTSAAKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUA2</accession>
    <name>A0A0D2WUA2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345303.1">
        <property type="nucleotide sequence ID" value="XM_004345253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUA2"/>
    <dbReference type="eggNOG" id="ENOG502SYSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUA2"/>
    <dbReference type="OMA" id="MINHIVE"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUA2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="341" mass="37793" checksum="1464331B6213786A" modified="2015-04-29" version="1">MLRTFTLRVAQPLARQVRAQSTAAAAATESPFGVNGTKSTPEQIKAAEAMWAKSARAFVNIPRENISFVAVPSATNEANVLPLFQIKGEPAAKNSFDAGLRHLTPISSLLIATLGRDGTTGRESFRGNVLIAEDQAEHQLLLSAAAIDGQPGINPTFQQYAEFYSFLRDELVAHVVANRDAYAPSYKKLRSVPVDRLKDFLLASYREPIHHREDSQGQLGADDYIVFKKRAFLKLDPKTYELRKSHANFDHELWASKKVVPYPIPVHDKFGTMLPNKTNDDRKLTRGDIVLAEVLLQPQLFELAGTFGMGFRRQLKSVVVLNRADRVAYSNQGTSAFVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUL7</accession>
    <name>A0A0D2WUL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUL7"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUL7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="815"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="1653"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1402"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1772" mass="194385" checksum="BE8C7F758C565EF8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUS0</accession>
    <name>A0A0D2WUS0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Skp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345769.2">
        <property type="nucleotide sequence ID" value="XM_004345719.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUS0"/>
    <dbReference type="FunCoup" id="A0A0D2WUS0">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUS0"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUS0"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUS0"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="160" mass="17208" checksum="39868C292B14576E" modified="2015-04-29" version="1">MSQIKLQSSDGREFTVDAKAAKMSETIKNMLEDLGGDGENAIPVPNVTGAILEKVISYCLHHKDDVPKVVEEDPSKPKKEEIDAWDAEFCKVDYVTLFNIILAANYLDIKPLLDVTCKTVANVIRGKTPDEIRKTLGVKSEAPASAASSSSSSAAEPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV41</accession>
    <name>A0A0D2WV41_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344516.1">
        <property type="nucleotide sequence ID" value="XM_004344466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV41"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV41"/>
    <dbReference type="OMA" id="AYHANNV"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV41"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29036" checksum="2CDC3EB6C2B51E64" modified="2015-04-29" version="1">MLSYQNMNQRQRQLYDKAKNASELLDLNDYQIGDAGAQAIAEALRVNTTLTEIRLQRNHIGDVGAQAIAEALKVNSTLTTLYLSGNQIGDAGAQDIAEALKVNTTLAVFFLRLNQIGDAGAQDIAAALEVNNGIKSLNLQENQIADVGANAIAEALKVNKTLTWLDLSQNFLTNTGINALRQTGNTICQFNSFFGRLDSQRTPSPADLAKIAARAASAQLQPSVDFAAENRQLRSTLAAKDQELAAKDQELAAKPQELDGKDQGLAAKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVJ0</accession>
    <name>A0A0D2WVJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_006578</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVJ0"/>
    <dbReference type="FunCoup" id="A0A0D2WVJ0">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVJ0"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVJ0"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVJ0"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="421"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="468"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE96223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="570" mass="61749" checksum="95830613F5598ADC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVL1</accession>
    <name>A0A0D2WVL1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinal degeneration B-PD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344236.2">
        <property type="nucleotide sequence ID" value="XM_004344186.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVL1"/>
    <dbReference type="STRING" id="595528.A0A0D2WVL1"/>
    <dbReference type="eggNOG" id="KOG3668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVL1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVL1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000028">
        <property type="entry name" value="Phosphatidylinositol transfer protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="5">
        <location>
            <begin position="578"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1213" mass="132892" checksum="255E5420639ADA00" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVN2</accession>
    <name>A0A0D2WVN2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344276.2">
        <property type="nucleotide sequence ID" value="XM_004344226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVN2"/>
    <dbReference type="STRING" id="595528.A0A0D2WVN2"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVN2"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="255"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="469" mass="51335" checksum="D1A294FFA286FD10" modified="2015-04-29" version="1">MFSSRLSFIGSGESAAAAGASHAAAVSSLASAGAGAGAGGGIGRNHSLPAMLNEGSGGGARGHHHPHHHQPSPLGLGSNSNSKDASSASSAMAGAAVAGGAHLDAASGGSASSSAMLLHQQHLLHQQQQQQQQQQQQQQQQQQQLHSMVTLGSVAKQSSRVAAAWVRFTSALREAAIIFFESQKDQIFERLSHFPARKLLLSASPFIAYLVVFKNYVFLRHATGLDELIEPNMTFLPWLEQLVFQCLPHRILARFANPLFDILAAIPYLIHFLLPALFIVYLYVTPRRRRDIFSFLWIFGWVNFIAVGFQFFFPTAPPWFTDSAVFDSKGELLDVGPAEAGFTRVDALIHYPLFHNIYAQSPLKFGAFPSLHVGWPMTVLACGPWVSFRVGLLHVIWIFWAAMYSNHHYGVDGLLGVGIVLFVSFMSTRFWSPFRKYTVEGHSRLPVFGSFARSESEPTTLLRTTVAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVP7</accession>
    <name>A0A0D2WVP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344304.2">
        <property type="nucleotide sequence ID" value="XM_004344254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVP7"/>
    <dbReference type="STRING" id="595528.A0A0D2WVP7"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVP7"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVP7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="382"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="599" mass="66427" checksum="2363C112EEB9D13A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVX1</accession>
    <name>A0A0D2WVX1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVX1"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVX1"/>
    <dbReference type="OrthoDB" id="5237615at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044251">
        <property type="entry name" value="LHP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47240:SF2">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN LHP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1795" mass="191331" checksum="71F96808B9574BDF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX29</accession>
    <name>A0A0D2WX29_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysosomal aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX29"/>
    <dbReference type="FunCoup" id="A0A0D2WX29">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WX29"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX29"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="107"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="11">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="426"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="507" mass="53899" checksum="010833FC1D24335C" modified="2015-04-29" version="1">MLPPFPTALRIASNIFSSTSHSFLSKVLFAFGQQQSSFLFPFLFPMRFTAFVAVALLGLVALSAAIPVAPGVVKVAISKAPAAINPNRRSLGANPAVNLGNFENAQYYGEIEIGTPPQKFKVVFDTGSSNAWVPSATCKITDLPCDLHKKYHSEKSSTYVANGTTFAIQYGSGSLTGYLSQDTFTVAGLKVTNQVFAEATNEPGLAFVLARFDGLLGLGFQEISVLNVVPVFYNMVAQGLLNSASFAFWLSRNGTSILKPGGELVLGGVDPSHYTGAFTYIPVSKPGYWQFALDSVQVGSTTFGANTQGIADSGTSLLAGPVADVKKINAQIGAIGILAEECDMIIEQYEPIIVEGLVQRLDPVTICKEIGSCKANASTSCYTCKLLITALDAELGNNRTQAAIEAALEGQCNRLPSPDGESLVDCTKLDTMPTISFVLGGKSFPLTPKQYVLEVTSEGQSECISGFIGLDVPPPLGPLYILGDVFMGVYYTHFDMANKRVGFALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXJ4</accession>
    <name>A0A0D2WXJ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007338</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343197.1">
        <property type="nucleotide sequence ID" value="XM_004343147.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXJ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WXJ4"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXJ4"/>
    <dbReference type="OMA" id="RCHTDEY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXJ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10005">
        <property type="entry name" value="HDAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="373"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="445" mass="50061" checksum="E22C31E249977A54" modified="2015-04-29" version="1">MTSKRRVSYFYDQDVGNFHYGPGHPMKPHRLALTHNLVLNYGLYKKMEVYRASRATDSDMQTFHAPDYIDFLKRVTPDNLSQFSQALSRFNVGEDCPVFDGVYDFCSIYTGASLQGAAKLNLQTSDIAVNWSGGLHHAKKFEASGFCYVNDIVIAILELLKYHPRVLYIDIDIHHGDGVQEAFYTTDRVMTVSFHKYGNNFFPGTGDLHEVGVQKGKLHSINVPLKDGIDDFSYKMLFNPIIGAVMENYQPTAIVLQCGADSLGCDRLGCFNLSIKGHGECVNFVKSFGVPTLVVGGGGYTIRNVARCWTYETSLLVDTTVSNDLPFNDYLEYFAPDFTLHPDTNTRVENENSRTYLEQLKNSVLENLRSLQGAPSVQMHEVPPDLIPREDQDDEADDPDERISQRASDKMVEHENELYEDDRDNDLIDNDAVANGTHSSNAMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXJ6</accession>
    <name>A0A0D2WXJ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_010172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXJ6"/>
    <dbReference type="InParanoid" id="A0A0D2WXJ6"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="280"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1531" mass="161149" checksum="242C196501C08109" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXU6</accession>
    <name>A0A0D2WXU6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342737.1">
        <property type="nucleotide sequence ID" value="XM_004342688.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXU6"/>
    <dbReference type="FunCoup" id="A0A0D2WXU6">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXU6"/>
    <dbReference type="eggNOG" id="KOG1086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXU6"/>
    <dbReference type="OMA" id="PDNYEPN"/>
    <dbReference type="OrthoDB" id="447025at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXU6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03567">
        <property type="entry name" value="VHS_GGA_metazoan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF1">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="662"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="81820" checksum="9068928C67734F5A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYB4</accession>
    <name>A0A0D2WYB4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346419">
        <property type="protein sequence ID" value="KJE98415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYB4"/>
    <dbReference type="InParanoid" id="A0A0D2WYB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="101" mass="10973" checksum="2CE29B036DB35906" modified="2015-04-29" version="1" fragment="single">MGGGWLGNAAQDNARGLKVSKSRIALQASSESDGATKGAARTAISIELFNRVFKQAWKSKRNGIAEELHRQERKAPPPQLQISKRSRGAVSATRMRVDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYY6</accession>
    <name>A0A0D2WYY6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346396">
        <property type="protein sequence ID" value="KJE98353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYY6"/>
    <dbReference type="STRING" id="595528.A0A0D2WYY6"/>
    <dbReference type="InParanoid" id="A0A0D2WYY6"/>
    <dbReference type="OrthoDB" id="10068095at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYY6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF543">
        <property type="entry name" value="L-SELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="284"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="355"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="482"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="544"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="606"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="872" mass="93469" checksum="5DB0A7DFA0560305" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ02</accession>
    <name>A0A0D2WZ02_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346413">
        <property type="protein sequence ID" value="KJE98393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ02"/>
    <dbReference type="STRING" id="595528.A0A0D2WZ02"/>
    <dbReference type="InParanoid" id="A0A0D2WZ02"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WZ02"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116989" checksum="67CE10B014A88D95" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X043</accession>
    <name>A0A0D2X043_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sphingosine kinase</fullName>
            <ecNumber evidence="7">2.7.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.91" evidence="7"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364939.2">
        <property type="nucleotide sequence ID" value="XM_004364882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X043"/>
    <dbReference type="FunCoup" id="A0A0D2X043">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X043"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X043"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X043"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008481">
        <property type="term" value="F:sphingosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000005">
        <property type="entry name" value="Sphingosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="9">
        <location>
            <begin position="180"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="603" mass="65413" checksum="EDC9F1569A8AAF48" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0B9</accession>
    <name>A0A0D2X0B9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0B9"/>
    <dbReference type="InParanoid" id="A0A0D2X0B9"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0B9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="473"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="815" mass="87825" checksum="B66DA68A077E4196" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0H7</accession>
    <name>A0A0D2X0H7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0H7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0H7"/>
    <dbReference type="eggNOG" id="KOG2218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0H7"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0H7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="847" mass="92769" checksum="4C412CC5B3044599" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X184</accession>
    <name>A0A0D2X184_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cbara1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_001686</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364554.1">
        <property type="nucleotide sequence ID" value="XM_004364497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X184"/>
    <dbReference type="SMR" id="A0A0D2X184"/>
    <dbReference type="STRING" id="595528.A0A0D2X184"/>
    <dbReference type="eggNOG" id="KOG2643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X184"/>
    <dbReference type="OMA" id="YPEYMFF"/>
    <dbReference type="OrthoDB" id="10056860at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X184"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE90364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="476" mass="51817" checksum="BF84B35379B8C7BC" modified="2015-04-29" version="1">MLQRSALRSALTVAVAAAEAAAPSATAACVARRACLSTSAPAAAASTLSAGSQRGWSSSSSSSSSSAYATGAAVAAALALLVTSNELANAAGNEDAAAAASDATAKKKKGFKESIVTRYENRLRQYSNPDKIFRYFATKELDGEVYMTPADFIRSVIPGEMQPQDLGLDQFEKVDVESFEKKMASFSGGKNFFALGNAGLLSFSEYIFLLTILSTPERRFEIAFRMFDLDGNGTVDLTEFQQVQSVIRRQFSGRSKDRASKQAKNSASDSSDNSQASGTISRSPLLLHFFGKDGSKLLTYAAFKSFVHDLQSEINKIEFQSYSRNEQTISEVAFAELLLSYADLKDEEDFVLRAKSREGQKPVTFKQFQAFNNFLKNIDDVEMALGMYTAAGASITKDDFKRAAKAVANVDLDNHIVDTVFNLFDKDGDGKLSNREFVAVMKKRASRGLDQHRDLGVVRGFKGLLICAKDKMKNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1T9</accession>
    <name>A0A0D2X1T9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008613</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270213.1">
        <property type="nucleotide sequence ID" value="XM_011271911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1T9"/>
    <dbReference type="STRING" id="595528.A0A0D2X1T9"/>
    <dbReference type="InParanoid" id="A0A0D2X1T9"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1T9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="634"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="72975" checksum="92E611F0107379C7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X272</accession>
    <name>A0A0D2X272_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003083</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363922.1">
        <property type="nucleotide sequence ID" value="XM_004363865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X272"/>
    <dbReference type="STRING" id="595528.A0A0D2X272"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X272"/>
    <dbReference type="OMA" id="PGMGAPF"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X272"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000194">
        <property type="entry name" value="ERAD-associated E3 ubiquitin-protein ligase HRD1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="293"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="734"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="734"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="802" mass="84658" checksum="95BBE23164660654" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X278</accession>
    <name>A0A0D2X278_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X278"/>
    <dbReference type="FunCoup" id="A0A0D2X278">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X278"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X278"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X278"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="607" mass="68114" checksum="917DFD0C383A1015" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2B7</accession>
    <name>A0A0D2X2B7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364120.1">
        <property type="nucleotide sequence ID" value="XM_004364063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2B7"/>
    <dbReference type="STRING" id="595528.A0A0D2X2B7"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2B7"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2B7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="7">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="8">
        <location>
            <begin position="356"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="542" mass="57301" checksum="115ED9E0A0E2AF08" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2N0</accession>
    <name>A0A0D2X2N0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363468.1">
        <property type="nucleotide sequence ID" value="XM_004363411.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2N0"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2N0"/>
    <dbReference type="OMA" id="NYEEECT"/>
    <dbReference type="OrthoDB" id="10069199at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2N0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255443" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1511"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="452"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="635"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="696"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="816"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="940"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1057"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1125"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1245"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1306"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1430"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1658"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1572"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1578"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1956" mass="205142" checksum="8366256FD4BB0714" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X309</accession>
    <name>A0A0D2X309_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348100.1">
        <property type="nucleotide sequence ID" value="XM_004348050.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X309"/>
    <dbReference type="FunCoup" id="A0A0D2X309">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X309"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X309"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X309"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="532"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="715"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1173" mass="130627" checksum="64A1EB1CC2111FF6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X399</accession>
    <name>A0A0D2X399_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270441.1">
        <property type="nucleotide sequence ID" value="XM_011272139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X399"/>
    <dbReference type="InParanoid" id="A0A0D2X399"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="11103" checksum="7DA17ABAC8CA6EA8" modified="2015-04-29" version="1">MRVSIVHVPSPNLQTYRGSALCPMGQCPIRDTVSTPWLSTVDWAVSTPLNSFAATFTPRQQLSRSTPSLSSVTPFDHHRFVGVDVRDLVVSVPAVVINGKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Z8</accession>
    <name>A0A0D2X3Z8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346334.1">
        <property type="nucleotide sequence ID" value="XM_004346284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Z8"/>
    <dbReference type="STRING" id="595528.A0A0D2X3Z8"/>
    <dbReference type="InParanoid" id="A0A0D2X3Z8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="711" mass="77647" checksum="ABA26E7474B939C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4I3</accession>
    <name>A0A0D2X4I3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345227.1">
        <property type="nucleotide sequence ID" value="XM_004345177.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4I3"/>
    <dbReference type="STRING" id="595528.A0A0D2X4I3"/>
    <dbReference type="InParanoid" id="A0A0D2X4I3"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4I3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="254" mass="26936" checksum="A489DD6D6C1D4220" modified="2015-04-29" version="1">MVKRQPAKSSSSSSSAAAAAAGATPFAQAAASAASAASAAVGRSSSSGSPSSSSSASRVSRSSELLEPTRTSQTAARPGLSLLLSESSAMDVDDDDDDDDQDQDQDQDDDNEYEDDDDDDDDDDNEENDESDQESASAGAGLPEFPFPRRIPNFKNGDNSSLSSVLDRVANFLPQMKAANVQLERVIATQGQKAVDIETVDEEGAYVEMDLSCGIIEQQNELTAETMRVQPELPQSSPQITAKHRTNKPLIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4I5</accession>
    <name>A0A0D2X4I5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4I5"/>
    <dbReference type="STRING" id="595528.A0A0D2X4I5"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4I5"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4I5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266811" description="Exostosin GT47 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="4">
        <location>
            <begin position="231"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="609" mass="68136" checksum="DF458F6E4908BC6D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X574</accession>
    <name>A0A0D2X574_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sedoheptulose-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X574"/>
    <dbReference type="STRING" id="595528.A0A0D2X574"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X574"/>
    <dbReference type="OMA" id="PNWTVGT"/>
    <dbReference type="PhylomeDB" id="A0A0D2X574"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF35">
        <property type="entry name" value="SEDOHEPTULOSE-1,7-BISPHOSPHATASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="7">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="347" mass="37024" checksum="AEA74D21E28BABFB" modified="2015-04-29" version="1">MSSTTTTTLADVLTAVVRDARLAATFNAIADATAQIADTLRSASVGKAGTTNVFGDHQLEVDVIADKIVFNALRDSGAVSVGASEENPVAVPLHQLEQVQQVSQKEEETTKVAFFTQEQSADARENGLVVTFDPLDGSSCIAPNFAVGSIFGIWPHGELIGRKCGDQLGSAISIYGPRDVLAIAIPASAAKDDKPHVVELTHIRGVWQVTIADMKIAADGKVFAPGNLRATADNPSYQRLVNYWISSKKTLRYTGAMVPDVFHILVQGNGVFCNPPSKTAPLKLRLLYEVAPLSLMIEAAGGRSTDGLNPSVMDRRVSDYDERCAVALGSSHEVARFLEYNVVADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5H0</accession>
    <name>A0A0D2X5H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342977.1">
        <property type="nucleotide sequence ID" value="XM_004342927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5H0"/>
    <dbReference type="FunCoup" id="A0A0D2X5H0">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5H0"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5H0"/>
    <dbReference type="OMA" id="KNDIYAD"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5H0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="90"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="198" mass="22424" checksum="6739FB6BD9DF9FB3" modified="2015-04-29" version="1">MSALRIHRRNVLVAVIVVFSLTLAGVALYRSKPLQLEDQQDEQRGWAAVANTLLNKRRQNSDDTTNGNSNRNSDDDDGKEDASIMAPMGNQTLRAELGRAGWTTLHVMAARFPEEPSQDEQDAFVAYIHLFGMLYPCGDCAREFRKLVQAHPPSVGSRDQAMQWFCEIHNHVNVRLNKPIFPCEKVRDRWQCGCVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5J5</accession>
    <name>A0A0D2X5J5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342589.1">
        <property type="nucleotide sequence ID" value="XM_004342540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5J5"/>
    <dbReference type="InParanoid" id="A0A0D2X5J5"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5J5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40353" checksum="46409F38697C48EA" modified="2015-04-29" version="1">MTNSTWLQTDITPNWNPLETWVVGVGLFLFVCQLGMALLLVVEREWKPFKAKQPVVLLVCVLSAILSFLGEMHAILLLPQEACYFWKQWALIALGLCLCASAHLYRFFTRWVVLKILTSQLISISKTFHRRAFQLAGALLIFLPVLVSSVAMGTVVEITIQPVVMANGELMNVCSSTHKTMLYTVNLAMGIYFCILGTWWTYTLRNVRAAFNEYRSARPGIFCSMLCLAGYFTARLLLDNAKFYNRALKLALNAGVSTPIFVAIAGGVVWDWLTRRDLAEKAFEAGMAMTMLSRAPLRGRSSLSQETQATSSRKSSVASSADSTRSAPLPEPTEYAVEVEDEDEVDLELELGLTPAAPSAVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9C372</accession>
    <name>E9C372_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348761.1">
        <property type="nucleotide sequence ID" value="XM_004348711.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270151.1">
        <property type="nucleotide sequence ID" value="XM_011271849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9C372"/>
    <dbReference type="STRING" id="595528.E9C372"/>
    <dbReference type="ESTHER" id="capo3-e9c372">
        <property type="family name" value="SERHL"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9C372"/>
    <dbReference type="OMA" id="HGWMDVS"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="PhylomeDB" id="E9C372"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="42"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="313" mass="33619" checksum="DCA0B08A5C80DA7D" modified="2011-04-05" version="1">MAAALVGQHAAGAIARQFSLPLRGGLGTVYGKAWGPVTGKRVLGVHGWMDNAGTFDRLAPYLPSDIQLVAVDLPGHGLSYHKKATYLMVDYVQDVKRIVDALGWTRFTYMGHSNGAAIGAMFAGTFPEMVERLLLIEGLAPFPGTDESAPEHLRAGIESNAALLGKPGKPYDSASAAIAKMRENNKALTEEAVQCLAARGMTTNSDGTTKFNHDPFLRANSLQRINVKQFHAFLGRVVAPTMIIRAKGGWPFPVDYFQGCVDVLSKSTSDFEFVDVEGDHHVHLTNPQNVAAAAHRFLEKSSVGAGTQTASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0P5</accession>
    <name>A0A0D2U0P5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365268.1">
        <property type="nucleotide sequence ID" value="XM_004365211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0P5"/>
    <dbReference type="FunCoup" id="A0A0D2U0P5">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0P5"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0P5"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="221" mass="22583" checksum="EBEBDF5196B77395" modified="2015-04-29" version="1">MASAAVRVATSAAARRPTKALMTVTAAAAAQLKVLLAEQPGSYGMRIGVKKRGCSGLSYTLDFADKKLPLDEEVKAEGLNVLIDSKALFSLIGTEMDYVSDRLRSEFVFTNPNVKSMCGCGESFNVVDTAADSNSGYIPTLANTPSPAAGQVGAVKAPVSSSSSSSSSSSSGAAVSATPAAASNGSVNTAVPNRSIHSLARQPQASKLLSPLIALATSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1A3</accession>
    <name>A0A0D2U1A3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SOWAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269944.1">
        <property type="nucleotide sequence ID" value="XM_011271642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1A3"/>
    <dbReference type="STRING" id="595528.A0A0D2U1A3"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1A3"/>
    <dbReference type="OrthoDB" id="5969290at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1A3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF7">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="642" mass="67641" checksum="363936A0739FD4A7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U214</accession>
    <name>A0A0D2U214_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365647.1">
        <property type="nucleotide sequence ID" value="XM_004365590.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U214"/>
    <dbReference type="FunCoup" id="A0A0D2U214">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U214"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U214"/>
    <dbReference type="OMA" id="QLPMKKW"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U214"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="401"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="607"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="799"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1073" mass="113302" checksum="0B893C61FFA62368" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6P5</accession>
    <name>A0A0D2U6P5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270177.1">
        <property type="nucleotide sequence ID" value="XM_011271875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6P5"/>
    <dbReference type="InParanoid" id="A0A0D2U6P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="154" mass="15623" checksum="E3325361B03CF79A" modified="2015-04-29" version="1" fragment="single">MVSFGLGIRKSNHKRSVSDSSAAANSSSSSSSTTVSSASTVTAFSSSSRHGTTHMASTSAASIASAAGANSASSMQGVLVERSKSKMNVLDCLHHQRDSPDPHARYVSIGASSTGRSMGARVNSPRATRHDDSALHRSISSSTSSASTASMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U878</accession>
    <name>A0A0D2U878_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U878"/>
    <dbReference type="InParanoid" id="A0A0D2U878"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="101" mass="10878" checksum="6FE4D051092403E0" modified="2015-04-29" version="1">MSSIAVSNLMPPHSAQCTASTAAVGERGAQASRTEKASFRQPPNSNKTDGVLLLRPIRPPSHCSPPSLQPNPLKRIILCRMQQGRSAGVEQIACCTERQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9N6</accession>
    <name>A0A0D2U9N6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363710.2">
        <property type="nucleotide sequence ID" value="XM_004363653.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9N6"/>
    <dbReference type="STRING" id="595528.A0A0D2U9N6"/>
    <dbReference type="eggNOG" id="KOG2320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9N6"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01776">
        <property type="entry name" value="RA_Rin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="617"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="810"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="96021" checksum="E2B798E601A22B76" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAX9</accession>
    <name>A0A0D2UAX9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAX9"/>
    <dbReference type="FunCoup" id="A0A0D2UAX9">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAX9"/>
    <dbReference type="InParanoid" id="A0A0D2UAX9"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAX9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="15">
        <location>
            <begin position="421"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="14">
        <location>
            <begin position="526"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="647" mass="70692" checksum="C952786BAD72958C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDH0</accession>
    <name>A0A0D2UDH0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363652.1">
        <property type="nucleotide sequence ID" value="XM_004363595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDH0"/>
    <dbReference type="FunCoup" id="A0A0D2UDH0">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDH0"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDH0"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="428" mass="44961" checksum="2E9ED4B9331EF23E" modified="2015-04-29" version="1">MSSKLPPTPLMLKGLVPYLQRADEFDKHDPVTAYYCRFYAAQNALKDPEASKDKQCRAFLIALMDKLEADKRSLSNLEAIRNDVVAAAHLEDFALKLFDFSDNEDREGRANKKVARSFYAASIVFDVLKSFGEMDTEIAEKHKYAKFKAVYITKCLKNGEVPIPGPPTGEDAVGGDDADFGQQSQPPPAQSQQFYDSSSTPPSYGADGGAPQQQPSFGGARPPGAFPVLPLTDVPSSPAGPAYPPRGASLGDVPVPPVNNPYGSISNFNSAPGGGNMYNPAMGMGNGPAAGGYPGPPSQQQHQQPPLPPSYPPNPSHFPSVPGAGGKGPTSGNSAPQQPPAAPTPAAPRPMAHVPNAPSPAPANIPSAAAQGMNALGNLQPRPSISLDDFAMAAKHAKFAISALQYEDVTTAITNLQNALALISVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFW8</accession>
    <name>A0A0D2UFW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347465.1">
        <property type="nucleotide sequence ID" value="XM_004347415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFW8"/>
    <dbReference type="eggNOG" id="ENOG502SZF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFW8"/>
    <dbReference type="OrthoDB" id="2110994at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="686" mass="74123" checksum="07DFC62664F1BA01" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UG60</accession>
    <name>A0A0D2UG60_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UG60"/>
    <dbReference type="InParanoid" id="A0A0D2UG60"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UG60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="422" mass="46587" checksum="AFC11FB4FBFDDFFA" modified="2015-04-29" version="1">MLSCQNMSERQRELFDKVENACKALDMDCSQIGEDEAWAIAEALKENRRLNRLNLDENQLGDAGARAIAETLKVNTTLTDLNLGQNQIGDAGARAIAETLKVNMRLTYLNLYGNQIGDAGAQAIAEALKVNTTLTKLLLFSNQLKDDGARAIAEALKANKRLSMLHLNSNQIGDGGASAIAEALKLNRTLTELYLGTNYLTEVGVSALRRSGNTTCKLKELDSQWTAVREYAREYTESQPSLNSQRTAVRARKYTESQTSVTLPTETLRFRSELAVKNLELAAKDQMLATKDQMLATKDQMLAAKEQMLAAKDQMIAVKDQMIAAKDQMLVVKEQELQQLRSELAVEGSGRVFFHYINYTGAANPNHALNHRHGAFSAILQALGAPDEHQWTCRGDPVRLVFLCRILSVVIAKMASVVDSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGG5</accession>
    <name>A0A0D2UGG5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347586.1">
        <property type="nucleotide sequence ID" value="XM_004347536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGG5"/>
    <dbReference type="InParanoid" id="A0A0D2UGG5"/>
    <dbReference type="OrthoDB" id="20660at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGG5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871:SF1">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="72858" checksum="6291ED8D64AFD6CF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH75</accession>
    <name>A0A0D2UH75_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346789.1">
        <property type="nucleotide sequence ID" value="XM_004346739.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UH75"/>
    <dbReference type="FunCoup" id="A0A0D2UH75">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UH75"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UH75"/>
    <dbReference type="OMA" id="VVCVIAW"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UH75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="744" mass="79197" checksum="7B7211575B469496" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI85</accession>
    <name>A0A0D2UI85_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346086.1">
        <property type="nucleotide sequence ID" value="XM_004346036.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI85"/>
    <dbReference type="STRING" id="595528.A0A0D2UI85"/>
    <dbReference type="eggNOG" id="KOG4042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI85"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI85"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="258" mass="26085" checksum="C63CA56097B66CDA" modified="2015-04-29" version="1">MSFDPTAFVCVEALVKGQVVVGPGCVVQPAAQITADDGCTIVFGSGNIVSERAVIRAVAPESPSQSQSQSQSQSQSYSSSGNVTVTVGAGNIFEPDCRVEAVSIGSGNIFGAKCVVQRGCRVGSGNYFAPGTLVTQARLDAAAAASPDGASVHNATSQPGRSPAAVIARAVEQQLGEAASSTSASSTLQAASRPMSRVPKPSSVAKQGQGNAQGSGNTLAAAPISQAVVDAMRPLETLQQPFLASQLPLFLHPQLSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UII8</accession>
    <name>A0A0D2UII8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346163.1">
        <property type="nucleotide sequence ID" value="XM_004346113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UII8"/>
    <dbReference type="FunCoup" id="A0A0D2UII8">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UII8"/>
    <dbReference type="eggNOG" id="KOG1006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UII8"/>
    <dbReference type="OMA" id="VEMANGC"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UII8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF15">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="165"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="463" mass="50216" checksum="E022E93D3D0930FD" modified="2015-04-29" version="1">MSTSHNSPSRPVSGSASAPSVVGASNPYYQPRSGLADGMGVMAPTPVGGLAASPTPSRSVDNASRDLHSLSLNSSPAHGISTPTRAQTAGGAVGGPGARGGGSLSMRKGPGKLSFGSQPTPQQAQPNIFNSERNALTLRAEDEQVTIPTQTVHLPNGTEISPESLKQLEEIGRGAYGAVHRSIYEPTKTIIAVKYIPMDITEESKKLQLIRELNVLRTATDDTEPCPYIVKYYGAYFREGDICICMEFMDGGCFDVIYKKTGPIPEKILGKISVAVVHGLHYLKSRLQIIHRDVKPSNILVDSSGKIKLCDFGISGRLENSVAKTYVGTNHYMSPERIALAGQYDIRSDVWSLGIALVELATAKYPYPPDASIFGILRHIVDGPAPSVPEGQFSPEFVAFLSKCLQKDHEKRANYVELLQTDFIKKYEQEEVDVAGWVQDVQSKIAVIRAAERVEHSHFPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIM9</accession>
    <name>A0A0D2UIM9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIM9"/>
    <dbReference type="InParanoid" id="A0A0D2UIM9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="205" mass="21719" checksum="F2F67C37C3CC3EC2" modified="2015-04-29" version="1">MALPFDRVTASGWSASSAVASPLLERLLLVSSWLLLPPPRRPASECPEAPPRRSAPRDAACAPDDAVEAAERMDDALVPARALRSSGSARFLALSLGSRCCCCCPCCCCCPCCCCCPAARPGDALVVIDAAFASVAATGAANPSPEPMPMPGSIEKPNAACAPALPPPIEPDRLRVMRRSPIAFFSLYLLMHKMTRKNERTHTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ49</accession>
    <name>A0A0D2UJ49_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ49"/>
    <dbReference type="InParanoid" id="A0A0D2UJ49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="15433" checksum="F9DF19AAAF65A335" modified="2015-04-29" version="1">MATARAKSKSRRRTGAGASSEAAAVAAAATTTTTTSTKGPVQYARLDPTNNSKSGLLLALQAQAAAAAAATALKASGVLGDARPPANAEVAAQLLLQAQDTAQATRPQALEQAATQFTAMVEEFNAQVDALQQDNVVTTTSIKRPRVRGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJI9</accession>
    <name>A0A0D2UJI9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJI9"/>
    <dbReference type="InParanoid" id="A0A0D2UJI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="11747" checksum="4FDDDED3E5D19460" modified="2015-04-29" version="1">MYRLSFSRGEVEMLLRATLEISWMATSCETDCTNEGDPDADGVLEVEASASEERDEDLLRVRTGVMTAESITGGVFCRSRDGSGAVGVESVSSRSSSSSDAGGVGFSIHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK32</accession>
    <name>A0A0D2UK32_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucuronat epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK32"/>
    <dbReference type="STRING" id="595528.A0A0D2UK32"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UK32"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UK32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="569" mass="61924" checksum="8740F095356362AF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULM6</accession>
    <name>A0A0D2ULM6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MLH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULM6"/>
    <dbReference type="FunCoup" id="A0A0D2ULM6">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2ULM6"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULM6"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="240"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="784" mass="85376" checksum="F4ABFA887B97CAF8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMS5</accession>
    <name>A0A0D2UMS5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypoxanthine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMS5"/>
    <dbReference type="STRING" id="595528.A0A0D2UMS5"/>
    <dbReference type="eggNOG" id="KOG3367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMS5"/>
    <dbReference type="OMA" id="MQWRVAP"/>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMS5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="237" mass="26685" checksum="14A6D6B61D026941" modified="2015-04-29" version="1">MSAKPHCIDIPDTNQGLALDLFTIPHHYKDAVSSVLISHGQILDRVEKLAQDITRDVGQKHLIAICVLKGGHQFFADLLLHMKKFNSREGSAPLSIDFIRVKSYHNDQSTGTVTITGGDLESIRGKEVLIVEDIIDTGKTMTMLLKELEKYEPAKVRVASLLVKRTHLSNGYVPDYVGFSIPDKLATLWTISFMPLLHAHTRFPTLLFAPYHRHTEWFRDLDHICIISDVGKTKYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQQ7</accession>
    <name>A0A0D2UQQ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQQ7"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQQ7"/>
    <dbReference type="OrthoDB" id="5954366at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF1">
        <property type="entry name" value="NEPHROCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253665" description="LRRNT domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1322"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1364"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1400" mass="136901" checksum="3BA84F8CF58D0042" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USG3</accession>
    <name>A0A0D2USG3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myotubularin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342587.2">
        <property type="nucleotide sequence ID" value="XM_004342538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USG3"/>
    <dbReference type="STRING" id="595528.A0A0D2USG3"/>
    <dbReference type="eggNOG" id="KOG0248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USG3"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="6">
        <location>
            <begin position="428"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="815"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="579"/>
            <end position="580"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="627"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112225" checksum="03FB741242236B0F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF83</accession>
    <name>A0A0D2VF83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364910.1">
        <property type="nucleotide sequence ID" value="XM_004364853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF83"/>
    <dbReference type="STRING" id="595528.A0A0D2VF83"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VF83"/>
    <dbReference type="OMA" id="SHADNIA"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VF83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000003">
        <property type="entry name" value="Putative rho GTPase-activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="526"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="764"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="954" mass="101315" checksum="D440130CE88B2F33" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG47</accession>
    <name>A0A0D2VG47_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365257.1">
        <property type="nucleotide sequence ID" value="XM_004365200.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG47"/>
    <dbReference type="STRING" id="595528.A0A0D2VG47"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG47"/>
    <dbReference type="OrthoDB" id="5968745at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG47"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254199" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="674"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="834"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="122246" checksum="72E7E4BE0442A04A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG98</accession>
    <name>A0A0D2VG98_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG98"/>
    <dbReference type="FunCoup" id="A0A0D2VG98">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VG98"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG98"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="5">
        <location>
            <begin position="223"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="378" mass="43676" checksum="68F5A78C5D7CCC2C" modified="2015-04-29" version="1">MPLVVAMMYEITNKDSFWRPYLDLLPETLDTPMFWNDDDLELLEGTSTLSHLGKEDAETIFTEQIVPFMKLHPTHFDLKVHNMALYHRVASVIMAYSFSEDDDEDDDDEDDDEEEDCCDGDANNECCSQKRQKRMEKIAMVPLADMLDHKTGCNNARLFYGKTTLAMSCIEPCAAGHELYNTYGDLSNSELLRKYGFIDDVNEHNSVDIPVEMLEERFESCSFMEEAMEALEEIGCWLPEFHIPADALPPQELEASIALLFQSPKQVRALRALDDEDEIRSFLATLVNKCRRKVSETLLAFGQKRAEEYTTTREEDEERLKESDLTHRQKMALRVRIGERTILHNYISHLKERLETTPPDQETKEPAPAHKNKKARKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGC7</accession>
    <name>A0A0D2VGC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365364.2">
        <property type="nucleotide sequence ID" value="XM_004365307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGC7"/>
    <dbReference type="FunCoup" id="A0A0D2VGC7">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGC7"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGC7"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="535"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="726" mass="80134" checksum="70420B97A6759F71" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGT5</accession>
    <name>A0A0D2VGT5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myocyte enhancer factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGT5"/>
    <dbReference type="STRING" id="595528.A0A0D2VGT5"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGT5"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="32090" checksum="089F715F16132285" modified="2015-04-29" version="1">MLDSTTSRPCTSPPPPHHRAIQVTFTKRKLGLMKKAYELSVLCECEIALIIFSNQNRLFQYASQDMDNILLKYTEYSEPHESRTNEDLAAQIAKKEARARGDSSLRDDSDSDTDGEDGIQSLDQKRAATDQIRQDFTLQSQQQQHHSTISANRIQQLQATSNDALQQLHNFQQQQQQQQQQPFSLIPPAYVPHPETLNGQPNLVFAPAPLSASSMPFGSALGSAGYFPSYNLGSAELANAQAGSTLPPHINLGAPPFYTPQFAQGGPAPGASATMPTPPLPPPPVTTAKSRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIQ2</accession>
    <name>A0A0D2VIQ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_001283</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349803.2">
        <property type="nucleotide sequence ID" value="XM_004349753.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIQ2"/>
    <dbReference type="SMR" id="A0A0D2VIQ2"/>
    <dbReference type="STRING" id="595528.A0A0D2VIQ2"/>
    <dbReference type="eggNOG" id="KOG1226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIQ2"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIQ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF3">
        <property type="entry name" value="INTEGRIN BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0401">Integrin</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254255" description="Integrin beta" evidence="17">
        <location>
            <begin position="24"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE89867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1064" mass="111259" checksum="F53FAEFF31362151" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK72</accession>
    <name>A0A0D2VK72_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rap guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364600.1">
        <property type="nucleotide sequence ID" value="XM_004364543.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VK72"/>
    <dbReference type="eggNOG" id="KOG3542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VK72"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="766"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="869"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1549" mass="166053" checksum="6DFE59BFB1E3BF0A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKD6</accession>
    <name>A0A0D2VKD6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270131.1">
        <property type="nucleotide sequence ID" value="XM_011271829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKD6"/>
    <dbReference type="STRING" id="595528.A0A0D2VKD6"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKD6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKD6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF79">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="14">
        <location>
            <begin position="758"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="807" mass="88417" checksum="7BCCE713E6EE44E5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMP4</accession>
    <name>A0A0D2VMP4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex I assembly factor TIMMDC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translocase of inner mitochondrial membrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMP4"/>
    <dbReference type="InParanoid" id="A0A0D2VMP4"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMP4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055299">
        <property type="entry name" value="TIMMDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002">
        <property type="entry name" value="C3ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002:SF1">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="283" mass="30830" checksum="86B36123EA6F2F32" modified="2015-04-29" version="1">MASDPSFSALGCDDGSEGGWANVRELFKDFGKSSSEMDATREAPPQLAEWAQMTGSAGLIGFFAGGNRGMIQAREAHIANNANTLYHGQFHAQVNGRIFLFGYWRDFSDFTWILLGFRLKLNLAHRLARYQSQRELNYSTFMGYSSSGMRMAGRLALVTGVMVGTSILIDRYFARTHDIRSAVAAGTLTGAVFSLTRGPAGFARGVALGAGLSSVWGVARAGALWAGHAIDPETYASPQYNQARLDQRDARDLRTKEAGVHVTAAIIDDLDQQIHAMRRDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP18</accession>
    <name>A0A0D2VP18_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_009633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP18"/>
    <dbReference type="STRING" id="595528.A0A0D2VP18"/>
    <dbReference type="InParanoid" id="A0A0D2VP18"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253761" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="731"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1020" mass="103924" checksum="1D521A8DA6C7A5D6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRM0</accession>
    <name>A0A0D2VRM0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">6-phosphofructokinase</fullName>
            <ecNumber evidence="4 15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008769</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4 15"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270399.1">
        <property type="nucleotide sequence ID" value="XM_011272097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRM0"/>
    <dbReference type="FunCoup" id="A0A0D2VRM0">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRM0"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRM0"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRM0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="415"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="779" mass="83392" checksum="64386CE845C048D8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRM7</accession>
    <name>A0A0D2VRM7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protrudin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger FYVE domain-containing protein 27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_004309</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348137.1">
        <property type="nucleotide sequence ID" value="XM_004348087.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRM7"/>
    <dbReference type="STRING" id="595528.A0A0D2VRM7"/>
    <dbReference type="eggNOG" id="ENOG502QVKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRM7"/>
    <dbReference type="OrthoDB" id="5975347at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15723">
        <property type="entry name" value="FYVE_protrudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042405">
        <property type="entry name" value="Protrudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543:SF1">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="466"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE93537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="535" mass="55829" checksum="599B66CDE4691C84" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRY8</accession>
    <name>A0A0D2VRY8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MENTAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348315.1">
        <property type="nucleotide sequence ID" value="XM_004348265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRY8"/>
    <dbReference type="STRING" id="595528.A0A0D2VRY8"/>
    <dbReference type="eggNOG" id="ENOG502RVFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRY8"/>
    <dbReference type="OrthoDB" id="17317at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRY8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560">
        <property type="entry name" value="POLYKETIDE CYCLASE/DEHYDRASE/LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34560:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="3">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="544" mass="60652" checksum="9EC4862DA1636ED5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTX6</accession>
    <name>A0A0D2VTX6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTX6"/>
    <dbReference type="InParanoid" id="A0A0D2VTX6"/>
    <dbReference type="OrthoDB" id="20660at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871:SF1">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="652" mass="72748" checksum="2FB5A6F8F189452F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV00</accession>
    <name>A0A0D2VV00_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probable oxidoreductase that may play a role as regulator of mitochondrial function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with COX5B; this interaction may contribute to localize PYROXD2 to the inner face of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV00"/>
    <dbReference type="STRING" id="595528.A0A0D2VV00"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV00"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668">
        <property type="entry name" value="PHYTOENE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668:SF103">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="137"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="658" mass="69698" checksum="039E8A29FB474B0F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVJ5</accession>
    <name>A0A0D2VVJ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345546.1">
        <property type="nucleotide sequence ID" value="XM_004345496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVJ5"/>
    <dbReference type="STRING" id="595528.A0A0D2VVJ5"/>
    <dbReference type="eggNOG" id="KOG0518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVJ5"/>
    <dbReference type="OMA" id="RCKIRVY"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVJ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21184">
        <property type="entry name" value="CH_FLN-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="123"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="228"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="48831" checksum="062B2E47417850B6" modified="2015-04-29" version="1">MSWQDIQVRVFTAWVNEQLKERGMRVGDKEPLHKEMIDGIALINLLEIISAKKLPRYNKHPRSPYQKLENQKIALDFIASEGLKLVNIGAEDLADGSLKLTLGLIWTLILRYQVQRGSGDDSLSAKSELLKWVQSKIPEYNITGFTKDWNNGKALCALTNAVAEGSFPNHASLDPTKGADNNRDGMNKANEVLHIPLIMNPEDLAHPKVDEQSVMTYISYFWRATPIAKPNQANQCSAYGRGLVEGIVSEPAEFTVETPSKDCGKLEVKVFGPANAPQNVQVTPVPNDPSRYNVVYNPTEPGDYEVHVTLDGVHIPGSIFHVTVLEQVSLGGEGKIRVYFSTTSSTDKGRKDVIELQKLLETKKIHERPDFEPWYPIDIWTQADRNAVFKRAGTRNLPIVFIDDEYAGDADRMYELEASGKLNQLLKYNENKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX66</accession>
    <name>A0A0D2VX66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345309.1">
        <property type="nucleotide sequence ID" value="XM_004345259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX66"/>
    <dbReference type="STRING" id="595528.A0A0D2VX66"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX66"/>
    <dbReference type="OMA" id="FKTMFEC"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="404"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="471"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="544"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="802"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="946" mass="102309" checksum="67893C13A0BBA6D0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYZ5</accession>
    <name>A0A0D2VYZ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYZ5"/>
    <dbReference type="InParanoid" id="A0A0D2VYZ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254027" evidence="3">
        <location>
            <begin position="26"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="841" mass="83636" checksum="0899FE9DF5132656" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZL3</accession>
    <name>A0A0D2VZL3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Shaker cognate l-PA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343602.1">
        <property type="nucleotide sequence ID" value="XM_004343552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZL3"/>
    <dbReference type="SMR" id="A0A0D2VZL3"/>
    <dbReference type="STRING" id="595528.A0A0D2VZL3"/>
    <dbReference type="eggNOG" id="KOG3713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZL3"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZL3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="295"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="704" mass="75803" checksum="82E405B775B42114" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0X8</accession>
    <name>A0A0D2W0X8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342581.1">
        <property type="nucleotide sequence ID" value="XM_004342532.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0X8"/>
    <dbReference type="STRING" id="595528.A0A0D2W0X8"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0X8"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
        <property type="entry name" value="CID_SCAF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF7">
        <property type="entry name" value="SR-RELATED AND CTD-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="745" mass="80623" checksum="9FBBADE712F0F244" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1H1</accession>
    <name>A0A0D2W1H1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEC14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1H1"/>
    <dbReference type="STRING" id="595528.A0A0D2W1H1"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1H1"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF66">
        <property type="entry name" value="PROTEIN REAL-TIME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="302"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="505"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="644" mass="72716" checksum="6D0E934600D21DCF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH37</accession>
    <name>A0A0D2WH37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH37"/>
    <dbReference type="STRING" id="595528.A0A0D2WH37"/>
    <dbReference type="eggNOG" id="KOG4676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH37"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="32035" checksum="6B603A7B81DA440C" modified="2015-04-29" version="1">MAAVAEPMAIDTASSDDNVAEATLAADAAPSTAPPAAAVSEAATALPVPPPAVACVVQVLNISPTATEAQLQQLFANIGPISRFRGGVSDPSLVGGAAARSCLVRYYNVDDARVACLLNNTMLLDRALLVTPASAAIAQPVLVEPLMPGPPRALLPGIAPASGLLPAPLPGAPPLTTAGGAAPRQPSASMTAANGNNAPSATGVIPAYLSPQHKASLLTGTNLPILPPLPAGLDAVKMEEMRRTMHVGNIANHATEEDIRYFFSNFGEISYIKLVTIEGQPARFAFIEFKELLGAYASLMAASQILLDRPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI19</accession>
    <name>A0A0D2WI19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI19"/>
    <dbReference type="eggNOG" id="ENOG502QRHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI19"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="380"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="664" mass="70385" checksum="91C20CA7573AC1CC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIC3</accession>
    <name>A0A0D2WIC3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIC3"/>
    <dbReference type="STRING" id="595528.A0A0D2WIC3"/>
    <dbReference type="InParanoid" id="A0A0D2WIC3"/>
    <dbReference type="OMA" id="ATHLQHD"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIC3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1075" mass="114744" checksum="1809E2CC19796050" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIP1</accession>
    <name>A0A0D2WIP1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365401.1">
        <property type="nucleotide sequence ID" value="XM_004365344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIP1"/>
    <dbReference type="STRING" id="595528.A0A0D2WIP1"/>
    <dbReference type="eggNOG" id="ENOG502RS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIP1"/>
    <dbReference type="OMA" id="WSLSYTS"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266386" evidence="5">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="68"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="416"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="509" mass="56122" checksum="8279C98AFB61AC92" modified="2015-04-29" version="1">MRAAVLLLVAAVVALAAAGSPFITVGDHFQFVAPDGRTRIFHGVNVVYKIFPYYPSQGAFDPVTSFNDQDIDNIVNWGFTFVRLGVLWAGVEPAPAQYNQTYLGELRSIVDKLYARGIYTLLDNHQDVLSPKYCGEGVADHLVHPNKYQGTFPFPVTNKPAIDPTTGYPLLADCLKINFADYYFAVEVGEAFQAFYDNTDSLGDKFAAFWQNVTGAFSDHPGVIGFELWNEPWNGDVVANPLLLEPGHADAKNLAPLWEKLHTAIRQVDTEHLVFYENVQSDAFFQSGFTQAPGGAAWANKTVFSYHVYCPDQNGHGDPANPDVCFAFDSAKIVESVHDAQRLKGGMFLTEFGAVAGDAAGVDEISRVTNIADSNLQSWSYWQYKYFNDVTTQSSVESLFLANGTVDAGKIQALTRTYALAVQGKPTRMNFEPTSASFDFSFNLDKSVSNNTEIYASTQYWYPKGVNIEIFPAGAATANYVPANNRIWIVPAANTPTNQTIRVVVTKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIP2</accession>
    <name>A0A0D2WIP2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366041.1">
        <property type="nucleotide sequence ID" value="XM_004365984.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIP2"/>
    <dbReference type="STRING" id="595528.A0A0D2WIP2"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIP2"/>
    <dbReference type="OMA" id="FSWPHPN"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254479" evidence="10">
        <location>
            <begin position="30"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="687"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="973" mass="102218" checksum="60B4F18646394E8D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIS4</accession>
    <name>A0A0D2WIS4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synergin gamma C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349740.1">
        <property type="nucleotide sequence ID" value="XM_004349690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIS4"/>
    <dbReference type="STRING" id="595528.A0A0D2WIS4"/>
    <dbReference type="InParanoid" id="A0A0D2WIS4"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039656">
        <property type="entry name" value="SYNRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463">
        <property type="entry name" value="AP1 GAMMA SUBUNIT BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463:SF2">
        <property type="entry name" value="SYNERGIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254482" description="Synergin gamma C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Synergin gamma C-terminal" evidence="3">
        <location>
            <begin position="808"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="990" mass="99139" checksum="DD8C2349878C6EAA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJH9</accession>
    <name>A0A0D2WJH9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365845.1">
        <property type="nucleotide sequence ID" value="XM_004365788.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJH9"/>
    <dbReference type="STRING" id="595528.A0A0D2WJH9"/>
    <dbReference type="InParanoid" id="A0A0D2WJH9"/>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="48305" checksum="B7F9BFD5078D0874" modified="2015-04-29" version="1">MADQPAERPRLKLLPKGATAQQQGEPDGSTTPTSAGAAPKSDPFGGARPREQNVSQEREARYREKEAEIDYERNASIDKVAAAKQQMLAQQQDQPQDQPQGQPAQQQQQRGLVGAAGVPIGAAAAGSMHSTRGEQQQQQRYQGQHAASPRRGGASGLSDFSQLRIAAEEAEEGFQRVEHGRRSQHQGQGQTSHGAFQKHQRPHHQQQQQQHHYDQQSSFSRDGAAGSHQQQHHQQHHQQQQHPRNPPPETYVCNLCHVPGHWIQDCEQAVKRSAPVAAGDASSVPAGASRASHNHQQQQAQPRSHSAGRQASSQQQPQQQADRPRRTAFPASFADDEEADPSLKTAQAAPQQSGRKPPETYVCHVCETPGHWIQECPNRSHNNPANPNGTSSSGPRPARSSGTAHSGATNRDGIPPPGYLCKVCNIPGHYVESHRTQRSEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJP8</accession>
    <name>A0A0D2WJP8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJP8"/>
    <dbReference type="FunCoup" id="A0A0D2WJP8">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJP8"/>
    <dbReference type="eggNOG" id="KOG4112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJP8"/>
    <dbReference type="OMA" id="ERVFMIA"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="117" mass="12590" checksum="5EE07FF8724D0884" modified="2015-04-29" version="1">MTSLFKRVVDTVPSIDYHGQKLAEDLFTWILSGSAVIAFAVGWMLQDFMMTLYLSAAAAAFCVLLVVPPWPFYRRHPVTFLPPLKGGDHGAAEGLATTTPLASSAPSSQPAEGAKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLH5</accession>
    <name>A0A0D2WLH5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364841.1">
        <property type="nucleotide sequence ID" value="XM_004364784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLH5"/>
    <dbReference type="STRING" id="595528.A0A0D2WLH5"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLH5"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="354"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="946"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="760"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130061" checksum="723C8D2F96C2C0AE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLL5</accession>
    <name>A0A0D2WLL5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349370.1">
        <property type="nucleotide sequence ID" value="XM_004349320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLL5"/>
    <dbReference type="InParanoid" id="A0A0D2WLL5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLL5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="148" mass="16370" checksum="A71E942867E49A63" modified="2015-04-29" version="1">MSSADAKPPATPSPQQQQQQPAPAAEATPGSSRTDLSPALGQMGPTPPFWTQEYWVRVPCARQSALTGLAAMITVCAVQTVRTRDANKALTQAAWSWFGAGMISWWVCRYNYRTNIIQLRRSVELYREGVREKEEHASTDSPTTERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLZ0</accession>
    <name>A0A0D2WLZ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLZ0"/>
    <dbReference type="FunCoup" id="A0A0D2WLZ0">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLZ0"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLZ0"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="75" mass="8249" checksum="4340D0C9416F1819" modified="2015-04-29" version="1" fragment="single">MSDAPTKQGPSAFLRHIIGKPVVVKLNSGVEYKGLLACLDGYMNIALEQTEEYVNGQLKSKYGDAFIRGNNVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMB4</accession>
    <name>A0A0D2WMB4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Secretory carrier membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349173.2">
        <property type="nucleotide sequence ID" value="XM_004349123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMB4"/>
    <dbReference type="InParanoid" id="A0A0D2WMB4"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39680" checksum="B1FE4E5E3E15D532" modified="2015-04-29" version="1">MSGWDNNPFGEKQSTPFDDPSVAQASTGGGAEDEYTRWAEQQAHLFQPSAAALSKSQEAAQDSYYKAPTAAAPPRPAPPRPSAPTKNAYADAPVSSPRQTASPSSSSYATPSHSSDFASKEAALRAREEALVAREAQLADRERALDESGLHPPNWPAFPKWCIFPFKPLIYHSIDDEIPAAQRVLIKRLFRDWIFTCFCWVINCIAAFSALVGCGDCSDTGTSFAVALIFMFVFIPGAFVCWYRVIYKGLVNDKTFSYLKFFFVFGFQVGCNILFAIGIPGTGASGFIVAFSAFSENTAVAIILLVSAVFWAINSVVSLFLLKQVFNLYRGSGKTVADAQAEVITSAAANPTIREGVKDSILRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMC0</accession>
    <name>A0A0D2WMC0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349183.2">
        <property type="nucleotide sequence ID" value="XM_004349133.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMC0"/>
    <dbReference type="FunCoup" id="A0A0D2WMC0">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMC0"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMC0"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="131"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="332" mass="36386" checksum="BCBE1F532CF8704A" modified="2015-04-29" version="1">MTIAVGFEGSANKLGIGIVRDDGIVLANVRHTFVPPPGEGFLPRDTAKHHQQYVLSLLQQALTSASLKPADIDVICYTKGPGLGAPLVSAAVVARTVAQLWDKPMVAVNHCIGHIEMGRLITGAKDPVVLYVSGGNTQVIAYSMNKYRIFGETIDIAVGNVFDRLARVLNISNDPSPGYNIEQLAKRGTTLLELPYTVKGMDVAFTGIIGKLETLARTNKYTKEDLCFSLQETSFAMLVETTERAMAHTGATEVLIVGGVGCNKRLQEMMEVMVAERNGKLYATDERFCIDNGVMIAWAGLEMFRVGVVTPLRETWCTQRYRTDEVDVTWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMU1</accession>
    <name>A0A0D2WMU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRT-like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349426.1">
        <property type="nucleotide sequence ID" value="XM_004349376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMU1"/>
    <dbReference type="STRING" id="595528.A0A0D2WMU1"/>
    <dbReference type="eggNOG" id="KOG3854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMU1"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="507"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="739" mass="81594" checksum="5A354EEA0CE88298" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNW1</accession>
    <name>A0A0D2WNW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364021.1">
        <property type="nucleotide sequence ID" value="XM_004363964.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNW1"/>
    <dbReference type="FunCoup" id="A0A0D2WNW1">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNW1"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNW1"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="24489" checksum="E1BB848EE7DEE18C" modified="2015-04-29" version="1">MDSAEQQHLQRMYRIYQTVMQMCHDRHYIVTADELEQNLETFRAKVCTGNDLTPVRERMLCNFAYKDDPTKSILVMFATEVKVGVAPIRQMIEQMSTQSIQRGIIVVQDCLTSFARSTLAEAMPQFIIEEFKEAELLVNITRHTLVPKHEVLSDDDKIALLKQYKLKEAQLPRIHSTDPVARYLGLRRGQVVRITRQSETAGRYITYRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPD7</accession>
    <name>A0A0D2WPD7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPD7"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPD7"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPD7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48492" checksum="50CE0FE29A68E701" modified="2015-04-29" version="1">MLSYQRMTGKQRKLYRQVKNEEITIDKVADKLDVAEAQVIAAALKVHATIEDVQLDQNQIGDTGLQAIAEALTVNTTVTHLGLQLNQIGDAGAQALAEALKVSKTLIWLDLNKNQIGDVGAGAIAEALKVNTTTLTELFLGWNQIGDAGAQAIAEALRVTTTLTFLDLRRNQIGDAGAQAIAEALKVNTTTLTELFMSANQIGDTGAQAIAEALKVNTTLTENQIGDVGAQAFAKVAQVRPMMTCIDLQGNYIGDAGTRAIEEARFANESSAIDFDNQISPLAFSLQPRSSTTTDIQTVFHLLTRGPFLPALPAEIADRVLDEACYWQGVRYIKRPSHDGQALEVRVPWSIDGNSIQVKAIQALRYRSNRTDTDNIVFDLIVRDEHCAVRYKCAAKPTFVESTVECATIERASHGILREMREGWTVQLMPGAQPGVVIESLYIGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPL0</accession>
    <name>A0A0D2WPL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348002.2">
        <property type="nucleotide sequence ID" value="XM_004347952.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPL0"/>
    <dbReference type="eggNOG" id="KOG2205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPL0"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1305" mass="142800" checksum="72721997FD564820" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPM2</accession>
    <name>A0A0D2WPM2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPM2"/>
    <dbReference type="InParanoid" id="A0A0D2WPM2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="351" mass="37671" checksum="979669CD62EE7184" modified="2015-04-29" version="1">MAVTTEPGGMRKSWSVSLKYLLTASWFSAVTLKRTSSRFARACLYSSKVTGCWLRSPTHGGKMAAGGTVASGWQAEQLDGRGGLEGDASAALLPPDVSSVDSNSDETHSPKTWYRRRRELPPRHSPSSSSSSSSSSPSSSCRCPRGDFFDTFAVASLDDASTDTDGVGSAVAVAGITRLLNSDSSSSEEALAERNAASCSMSMCEVRGHEKVSSWWSKRSGTGNTRMLKMLSAATANRVGRKQFLASRALRCLAQLAFRQQPPRCAFSTRNGVVSSLLSSLLLWLLLSWDVAVVAVVAAWLCCFPADVEDKASMFPHVGCCCDCWCGCRRGVLRTAEAKPAVSEYPDMQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPV7</accession>
    <name>A0A0D2WPV7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348136.1">
        <property type="nucleotide sequence ID" value="XM_004348086.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPV7"/>
    <dbReference type="eggNOG" id="KOG1912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPV7"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPV7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="2">
        <location>
            <begin position="639"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="2">
        <location>
            <begin position="752"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1722" mass="180320" checksum="1C2813EE9757122B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQA1</accession>
    <name>A0A0D2WQA1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363634.2">
        <property type="nucleotide sequence ID" value="XM_004363577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQA1"/>
    <dbReference type="STRING" id="595528.A0A0D2WQA1"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQA1"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="14">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="197"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="529"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="756"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="890" mass="98910" checksum="BC06150B84E43841" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQP5</accession>
    <name>A0A0D2WQP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270388.1">
        <property type="nucleotide sequence ID" value="XM_011272086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQP5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQP5"/>
    <dbReference type="InParanoid" id="A0A0D2WQP5"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="293"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="53690" checksum="5EFD4FE3797DE06B" modified="2015-04-29" version="1">MKPRALVLIPFAAAVLLCSGLVLWPSMMLVQEQGTTVDYYADDQRNPFVEAWQALDPELSQLLRQPDQAIQRPSAELLDSHDQRDGLVVLATHPIGFLGRYATVHDPHATGDAVVFGWPGFEINAVFTGASSIAAVLAGPVIATQLAGTDSSVTVNLNDVQQGLDPSPHSSDCDFNVYVDGVQLSPLPPKTPVLSLSTDMVAAQQLVSGLDETAVHSVRIVKRTDSRALHTSVRQGVCAFYGFRLHSTGQMPPRLLPPPRPAVFAHGSHADMLNAVAGGTVHQRLTNPPRLVFYGDSVTAGSAALQNISCAKNVRDVRASYSSKVTKALHAEAHYIARSGMGVLRSNSVEAKTVMKDVMHLSMAAPSAPRWDTTLFAPDVLVLNLGTNDFIGWGSITPAFAASFTEGYQSLIQELRVAHNQPNLPVYLLCGPMHFEKAGCEAIKAVADLVGGTFLNVTDIIGPSDWGCRSHPGESGNEKIAAFVAERLRVDFADIWPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQR3</accession>
    <name>A0A0D2WQR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_004167</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347992.1">
        <property type="nucleotide sequence ID" value="XM_004347942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQR3"/>
    <dbReference type="FunCoup" id="A0A0D2WQR3">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQR3"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQR3"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="124"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="803"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE93368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122774" checksum="BBF92E5DB65095B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQT7</accession>
    <name>A0A0D2WQT7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347533.1">
        <property type="nucleotide sequence ID" value="XM_004347483.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQT7"/>
    <dbReference type="STRING" id="595528.A0A0D2WQT7"/>
    <dbReference type="eggNOG" id="KOG4734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQT7"/>
    <dbReference type="OrthoDB" id="534063at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQT7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="947" mass="100156" checksum="33F71E4E868196F5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQW5</accession>
    <name>A0A0D2WQW5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAOG_004265</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348090.2">
        <property type="nucleotide sequence ID" value="XM_004348040.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQW5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQW5"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQW5"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 21 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="23">
        <location>
            <begin position="322"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="731"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="630"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJE93478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="841" mass="92291" checksum="BE4A1591C67EBC9B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR37</accession>
    <name>A0A0D2WR37_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein furry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346655.2">
        <property type="nucleotide sequence ID" value="XM_004346605.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WR37">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WR37"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR37"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="411"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1884"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="2000"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="2242"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="2371"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2502"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="3399"/>
            <end position="3721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1750"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2314"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2793"/>
            <end position="2830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2847"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2983"/>
            <end position="3005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3084"/>
            <end position="3339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1754"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2316"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2804"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2851"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3110"/>
            <end position="3121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3168"/>
            <end position="3192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3218"/>
            <end position="3230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3263"/>
            <end position="3299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3323"/>
            <end position="3333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3728" mass="396497" checksum="F1EF8B110BD676B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR88</accession>
    <name>A0A0D2WR88_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR88"/>
    <dbReference type="STRING" id="595528.A0A0D2WR88"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR88"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR88"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047326">
        <property type="term" value="F:inositol-1,3,4,6-tetrakisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="350" mass="38934" checksum="4C3829C8DB0978E8" modified="2015-04-29" version="1">MQVGDLRSSSTGTLQPSHTHHQQHLGESLEHQQEQQQQHRQQQQLSELAATARAGHVDHLVRCDHQVGGHKPEEGKGKPLFQQGAFVFKPLPVGDPRSFHELLFYERIFDLKTPSTPGTAAIAHEMPLPRSEDVQELRLLVPKFAGVVLADDDSVEDLTKGNNSYLKMEDTSASFRKPCIADIKMGIQTWGENASESKIAKEREKYPPQQTLGFRVVGMKVYNATTDVFQPYGRKFGLGLDESTVAQGCRTYLSTDGGASIQREVLQLILVKLRAILSWFERQRSFRFYGSSLLLTYEGAAQAGAPPAVDVRMIDFAHVFPIVASDNGSLGRDDGYIHGLTTLIRVLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSN9</accession>
    <name>A0A0D2WSN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_005733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSN9"/>
    <dbReference type="STRING" id="595528.A0A0D2WSN9"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSN9"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="709"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE95260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="998" mass="105629" checksum="62948276548D2A12" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU24</accession>
    <name>A0A0D2WU24_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU24"/>
    <dbReference type="InParanoid" id="A0A0D2WU24"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="234" mass="23987" checksum="5C161BFE4CA3030A" modified="2015-04-29" version="1">MPGSGVAVCEATLVSVGRTSCEGFGLLEGFSECFCHASWGEARTSAEKSRFGPSKYFHASCREARTSKYLQISGEETRPELPGSLEVLDQREALGPSSEVDGAGGLSCSGSPEALGFLAAPGSPAALGFSEVVGPSEVEDAEAGLGSEAPGCPPAEAEAVGLPAEVLEVLGFPAEARCSPRSPGSPPEVGAGCAEAGLGFSKSDSCTFLCVLGAFSKFQNFKISKFQNFQNTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV88</accession>
    <name>A0A0D2WV88_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV88"/>
    <dbReference type="InParanoid" id="A0A0D2WV88"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="518"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="77085" checksum="0FCBD673649EBD4C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVB2</accession>
    <name>A0A0D2WVB2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Eukaryotic translation initiation factor 4 gamma 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_007037</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. Interacts with DAZAP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343761.1">
        <property type="nucleotide sequence ID" value="XM_004343711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVB2"/>
    <dbReference type="STRING" id="595528.A0A0D2WVB2"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVB2"/>
    <dbReference type="OMA" id="CAPLDIN"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVB2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MI" evidence="19">
        <location>
            <begin position="636"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="18">
        <location>
            <begin position="840"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="426"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE96765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112363" checksum="FC27B5B5D961878F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVI3</accession>
    <name>A0A0D2WVI3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCD1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVI3"/>
    <dbReference type="STRING" id="595528.A0A0D2WVI3"/>
    <dbReference type="InParanoid" id="A0A0D2WVI3"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="2">
        <location>
            <begin position="42"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="406" mass="44111" checksum="4CAC9EC449CAEF92" modified="2015-04-29" version="1" fragment="single">MTDDTMAEDVRLLEDAQRTAMAAKRETIQPRPNPNALPSTVNALRRAALERQIRVIFLPAGLQRRRDNTSFVNARKKQIQWRVEWLISIGNIVPLRYFEDQYVSAGFDACLASKRISDLGDHVVSPPVSPCLPPISSVSENLPLASIASRLLAGRTIKDEILRERIATAMAVLPAAAQPSSTEVPAESLVGFSILFKPDGQPANAARYYRFPDLSLSLRLALAGLTILEHPTLYLVADQALDRFNLLSSREELVQMCNSANSPINQLAMVDARQHTRSGKREGDRSSRDKRTLNSAPSHPLIQELPDPSSEGLAVVDAGLLPTPLLDATPHPEATMVPNSPGGDYDEEDDGDAFDQSDRSVAPISHADIAMETRGAVSHPPSSTATGGNHALKMLDYASSGDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVK1</accession>
    <name>A0A0D2WVK1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006602</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344223.1">
        <property type="nucleotide sequence ID" value="XM_004344173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVK1"/>
    <dbReference type="FunCoup" id="A0A0D2WVK1">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVK1"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVK1"/>
    <dbReference type="OMA" id="KDYHHYH"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVK1"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023471144" description="Phosphatidylserine decarboxylase beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023471143" description="Phosphatidylserine decarboxylase alpha chain" evidence="12">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="100"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="432" mass="46907" checksum="EBBFA534342129A2" modified="2015-04-29" version="1">MLGRLALLRLGSAAQTAARIGVPRPPLVLLPSSSSSSPSSSSSSSSFSQVLMPRAGRSMATSTATSQGSGSKSKQRHWPAWLAPSAIVCAGVVYVQHERALFENEQARLVATEGPDAVLASTEAQRRQSVQVTLLRTLPTRALSRVWGAFHELELPVWIRAPVYKTYAAMFGCNLDEMAQKDLSAYPNLSAFFMRHLVENARPIASSLMVSPADGKVLHFGVVDDDVIEQVKGVPYSLQHFLGETPKTERADRTGHSKPGDAKKLFHIIIYLAPGDYHRFHSPAQWTATKRKHFPGELLSVAPAVAEIIAGLFAFNERVVLLGKWAHGFFSFSAVGAYNVGSILINMDKDLMTNRGTKYSRHTVFDKELGAIAVGKGEEIGTFNLGSTLILIFEAPADFQFSVSNGQKLQVGQPLGDVVSKEAKPSSSGRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVP2</accession>
    <name>A0A0D2WVP2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344295.1">
        <property type="nucleotide sequence ID" value="XM_004344245.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVP2"/>
    <dbReference type="STRING" id="595528.A0A0D2WVP2"/>
    <dbReference type="eggNOG" id="ENOG502QSJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVP2"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="390" mass="42824" checksum="C601251D0F642627" modified="2015-04-29" version="1">MIRSVAFELTKRASSSSVAAVAASMRATTRCAAVAATSAVVRGMSTSANNNNQQEQDKQQQNNEQSESTASKLTKPGFVAAAAVALVVWQLESRGERFGASVDGGHQSQEPRGLISSWVAKALGHSTVRANARLSEDSNVRALIAEAAMGKTGSRQFTSLMTTVCQHADRLYDGGHMDDLYAFLHATMAADSPLKSGAIAWRAARAARERSLATTDAELKKKLVYEAYELAKRAIEYDPSDFACHKWLGITISDVGEYEGVKVKISNAFTIKKHFDEAVRLNPDDPTSRHLVGMWCFTFADMPWYQRKIAATLFATPPSATYDEALGHFVAAENIEPGFYVKNTLMIGKVYLRMGQKEEAKKYLTKTIFQAKTEADRESLEEAKQILEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVR7</accession>
    <name>A0A0D2WVR7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVR7"/>
    <dbReference type="InParanoid" id="A0A0D2WVR7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="96" mass="8968" checksum="1409A8FA07DD90EA" modified="2015-04-29" version="1">MTGPSKNSGTGPGQPAIASALAAAAQHQQRARTASPSSQVDMTSNDPAPVLPTATSGGNAAPGTAGNTNASTTTTPGQAGQATATAPTAASAARPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVV5</accession>
    <name>A0A0D2WVV5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344405.1">
        <property type="nucleotide sequence ID" value="XM_004344355.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVV5"/>
    <dbReference type="FunCoup" id="A0A0D2WVV5">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVV5"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVV5"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVV5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="115"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="35119" checksum="E5B7C852E28C7DC6" modified="2015-04-29" version="1">MEPAESTTTNTTTSTTSNCSSSSSSTQPQEGEIQPLVVARTQSVEARQLSEAEAAMVAATKMTVSEYHKSRFDTHARMFWDKFYHANKTFFFKDRHWLYREFPPLVEQEPVHTLLEIGCGVGNAFFPLLQANPTIEVYACDFAKKAVDLITQNELYKANASRCHAFVCDVINTPISDTVPANKVDLCTCLFVLSAMVQSKMPAAVSNIFNALKPGATLFFRDYGINDEAMLRFAKQRNSKLDENLYVRQDGTQAFFFTLEHVQELFQSAGFEQLSSVYVFTETINRKEELQVPRVFVQSLFRKPDTSAPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW61</accession>
    <name>A0A0D2WW61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAYSvFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343494.1">
        <property type="nucleotide sequence ID" value="XM_004343444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW61"/>
    <dbReference type="eggNOG" id="KOG3249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW61"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="3">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="155" mass="16815" checksum="A23A1A016637D6FF" modified="2015-04-29" version="1">MAPIASKPDPSRGTPMAMAALRRREQKQESSDPSSPPSNGAPAAATPAAAETDVLVAAWDWITRNVALATALKAVLWVLLLLIFAELEFGTVFVILSTPWLIFTNLGSGESAAERRRRDPHAKSAYSVFNKNCEPLQGELRAEQLDAALRQGRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWL6</accession>
    <name>A0A0D2WWL6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343906.1">
        <property type="nucleotide sequence ID" value="XM_004343856.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWL6"/>
    <dbReference type="STRING" id="595528.A0A0D2WWL6"/>
    <dbReference type="eggNOG" id="KOG4849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWL6"/>
    <dbReference type="OMA" id="YGDERCQ"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="535" mass="54642" checksum="AC5224894F3229BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXV2</accession>
    <name>A0A0D2WXV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXV2"/>
    <dbReference type="STRING" id="595528.A0A0D2WXV2"/>
    <dbReference type="InParanoid" id="A0A0D2WXV2"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57455" checksum="4CCAE1B866BD9F73" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY93</accession>
    <name>A0A0D2WY93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346407">
        <property type="protein sequence ID" value="KJE98380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY93"/>
    <dbReference type="STRING" id="595528.A0A0D2WY93"/>
    <dbReference type="InParanoid" id="A0A0D2WY93"/>
    <dbReference type="OrthoDB" id="6156466at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056806">
        <property type="entry name" value="EGF_STAB1-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24887">
        <property type="entry name" value="EGF_STAB1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266666" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="258" mass="26697" checksum="065463A81C3E0690" modified="2015-04-29" version="1" fragment="single">MSRTRSGLVVLLLLAALCCQHATAQSSQTLMLYNLGLVPSDPSALVVNTTQFYATVCIRDATVNPSDCAQTTTTPVFTVPETGSISPPSVVYSNPSAVLTPYNFDVYVYRVADAVLAPDQLVAFLHRENSVMVWGQTDEFGGSATPSAMPQSIAPSPTAGAASTTTWTSTISYNIQIACTSDHYGPFCNISCSPAITCSGSGSCVSETGACACDSGTYGSDCSMTCTCVHGTCDETSLDGSCVAGSCEAGFEGPLCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYY8</accession>
    <name>A0A0D2WYY8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346398">
        <property type="protein sequence ID" value="KJE98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYY8"/>
    <dbReference type="STRING" id="595528.A0A0D2WYY8"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYY8"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYY8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254912" description="LRRNT domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="931"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="966" mass="98765" checksum="8E72BE6DDA66449F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0L7</accession>
    <name>A0A0D2X0L7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365651.2">
        <property type="nucleotide sequence ID" value="XM_004365594.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X0L7">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0L7"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0L7"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0L7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="619"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1684"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1758"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1989"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1721"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2000"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2039"/>
            <end position="2048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2048" mass="220618" checksum="3C79064FC2C9ADD1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1H2</accession>
    <name>A0A0D2X1H2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TipD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348800.1">
        <property type="nucleotide sequence ID" value="XM_004348750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1H2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1H2"/>
    <dbReference type="eggNOG" id="KOG0288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1H2"/>
    <dbReference type="OrthoDB" id="2271613at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1H2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="107"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="340" mass="37293" checksum="3958309E5318C1AB" modified="2015-04-29" version="1">MATLSQQQQVPPSSPGGMLKGLASTSSLASISSAAPAPAPASASATASATATASASSPLAAAESALVLGAWHRPAAPPSALGSASESAVFLLQSPAGTLLLPWKRTMLKHLVERNGAQCDSFASLIDHHIKQMDVLDEHQAKMTSATRELASLQQENRELKHQLAMSKDHSEMSSALAVRDKVSALEEKLQRTQEELTESYKLKGQNAQMLLDLSQQIKVKDEELRQRQTEHKELLARIATSEKACEDVTARFNESMVAIQILQDELQALQLELLKVEERNKILEVENTSLVERWLRKMNEEALKMNEANMFYESVVDMKKREALMDAAQDKLSLIRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1N5</accession>
    <name>A0A0D2X1N5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na+/H+ antiporter NhaC-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349053.2">
        <property type="nucleotide sequence ID" value="XM_004349003.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1N5"/>
    <dbReference type="STRING" id="595528.A0A0D2X1N5"/>
    <dbReference type="eggNOG" id="ENOG502QWQB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1N5"/>
    <dbReference type="OrthoDB" id="5593520at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1N5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43478">
        <property type="entry name" value="NA+/H+ ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43478:SF1">
        <property type="entry name" value="NA+_H+ ANTIPORTER NHAC-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Na+/H+ antiporter NhaC-like C-terminal" evidence="8">
        <location>
            <begin position="357"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="807" mass="86746" checksum="E00111C2C73C4512" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q6</accession>
    <name>A0A0D2X1Q6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal sequence receptor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349140.1">
        <property type="nucleotide sequence ID" value="XM_004349090.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q6"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Q6"/>
    <dbReference type="eggNOG" id="KOG3317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Q6"/>
    <dbReference type="OMA" id="YGFFNYT"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Q6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254964" evidence="2">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="192" mass="20761" checksum="B95E135C61A62F36" modified="2015-04-29" version="1">MRQSTLLLVAVAVMACVGGAFADSAYILASKSILNNYLVENMDITIQYSLFNIGEGAASSIQLLDYFPQEGFNIVAGSTSAKWDHLAAGANVTHLVVVRPLSHGRYNFTFGQVSYLETADASDPVVALTSAPGVQQIYPFNDYDRQYASHILQWAVFAVATAVLVGGPAFLYLGSRAKYVAVAAEEKNRKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1R1</accession>
    <name>A0A0D2X1R1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349163.1">
        <property type="nucleotide sequence ID" value="XM_004349113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1R1"/>
    <dbReference type="STRING" id="595528.A0A0D2X1R1"/>
    <dbReference type="eggNOG" id="ENOG502RTPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1R1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="741" mass="81420" checksum="53A8F870F2796065" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1V0</accession>
    <name>A0A0D2X1V0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349328.2">
        <property type="nucleotide sequence ID" value="XM_004349278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1V0"/>
    <dbReference type="STRING" id="595528.A0A0D2X1V0"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1V0"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1V0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="46198" checksum="A7E5BACBC8DCAAC3" modified="2015-04-29" version="1">MVCGTRFDCPAKYSLIKPIGGAYGVVCSAQNNLLGRRVAIKKIIKAFEHLTDSKRTLREIKLLRHFHHENVLSIEDMLQPTSYEQFDDVYLVSELLDTDLHQIIGSPQQLTDDHCQYFLYQILRGLKYIHSAGVLHRDLKPSNLLLNGNCDLKICDFGLARVAQAGDASAAGFMTEYVATRWYRAPEIMLSWREYTKAIDMWSVGCIFAELLGRRPLFPGKDFLHQLSLITDVLGSPSNDDIAGISNDKARRFVRQLPAKPRIPFQTIYPNANPIALDLLQRFLMFNPDNRISVEEALAHPYLAPLHDPADEPTCHSTFNFDFENRPLTKEIIKELTFQEMLAFHPPVAGDEHALFLHSQLQILQQQQVLRAQQLILYEQAVIPPEGGGELPFDAVLSDDMIAPYAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1W2</accession>
    <name>A0A0D2X1W2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Srrm2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349383.2">
        <property type="nucleotide sequence ID" value="XM_004349333.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1W2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1W2"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1W2"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1W2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="387" mass="43957" checksum="081EFCBD4BC8B7AD" modified="2015-04-29" version="1">MSYNGIGLTSARGTGTNGYIQRNLSTIKWRPESAQARHDELSQQQKHRLDRDLHREPNAEILAHERKRQVEVRCMALQDELEEKGIKEAVIESRVAELREQLLSELQSETAAALLPQQQGNQRLSETHQLAAAQQAKNERTRSALGIEEGYVEGSAFDPETQQRKREERIAQREAQQAAYEAQRAVREAERAARLAERDARDAERRQQQQEQDRERRSRRSEDSDAASKKSDAPEAGEANRGESAAPRHESKRRRYDSESSTVARRRSPSASRSRSRSRSPSRSPVRRGRSRSPAQRRAQRSRSGSGSRSRSRSPPSRSRTSRRRSASRSRSRSPVQQRRNRSPSPAAAEAPRRSVARLSRRGDSSPPPQQQPPQPEPVQQEKEAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y0</accession>
    <name>A0A0D2X1Y0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349462.1">
        <property type="nucleotide sequence ID" value="XM_004349412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y0"/>
    <dbReference type="InParanoid" id="A0A0D2X1Y0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="154" mass="16239" checksum="00D0F03FBD42A98A" modified="2015-04-29" version="1">MEEDAPAGSDDSSDAEEDGNFEGSDSEDMDVSDPEYNGTAATSATKTTPKGRARKVAGSGAAAKLAATSSASTRQRKLSQSSDSSDVPAQASGSIDKRSLKRLRNREAAARCRNRRRQLIDELSTQVAELVAEKTTMAATIARLEAELATTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X253</accession>
    <name>A0A0D2X253_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270262.1">
        <property type="nucleotide sequence ID" value="XM_011271960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X253"/>
    <dbReference type="STRING" id="595528.A0A0D2X253"/>
    <dbReference type="eggNOG" id="KOG1557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X253"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X253"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="35024" checksum="0907E962EA13641D" modified="2015-04-29" version="1">MAYLSAEQKTELARIANYIVAPGKGILAADESTGTIGKRFDSIKVENTEENRRAYRQLLFTGDKAISDCLGGVIMFEETMYQKSDDGKLFPALLKEHGILTGIKVDKGTVNLPGLDNETTTQGLDGLLERCQKYKKDGADFAKWRSVLRIGANQPSELAVYENAKVLARYASICQQGGLVPIVEPEILMDGDHDLKKAVRTTEYVLATCYQALVAHHRTVPVAVPGVVFLSGGQSEEEATVHLNAMNALQTKKPWALSFSYGRALQHTVLKTWKGDKANVAAAQQALLKRAKANSDATLGKYQGSTDASASEKLFVSNYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X343</accession>
    <name>A0A0D2X343_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348243.1">
        <property type="nucleotide sequence ID" value="XM_004348193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X343"/>
    <dbReference type="FunCoup" id="A0A0D2X343">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X343"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X343"/>
    <dbReference type="OMA" id="MDLIPFF"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X343"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="257" mass="28911" checksum="4411A9E1F6BAD4C7" modified="2015-04-29" version="1">MSDAPSIITQVNRDGTPAHTAAGGKSAQKAKYPARRGIWSLLFCCGRGTQEAESPEHVTDRTVTESQSDYNGEPLLGPLRKDDKGRKCLVLDLDETLVHSSFRPIPNPDYIIPVEIEGIVHQVYVLKRPYVDEFLKRVGQLFECVLFTASLAKYADPVSDLLDKDRVLRSRLFRESCVQHRGNYVKDLSRLGRELSQTVIIDNSPASYAFHPDYAIPIVTWFDDKNDTALLDLIPFLEYIAKVDNVQTALRAKPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C3</accession>
    <name>A0A0D2X3C3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-catenin-interacting ICAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270458.1">
        <property type="nucleotide sequence ID" value="XM_011272156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C3"/>
    <dbReference type="STRING" id="595528.A0A0D2X3C3"/>
    <dbReference type="eggNOG" id="ENOG502QPUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3C3"/>
    <dbReference type="OMA" id="TKMMAGN"/>
    <dbReference type="OrthoDB" id="10262856at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3C3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="190" mass="20909" checksum="0CE40CC7E746A29F" modified="2015-04-29" version="1">MASRGKTETAKLKQNVEEQLDRLMQQLADLEECKADLDASEYEETKNETVAQLKEFDASLKKMIAGDMSLVDSLGSMQLAIQAAISNAFKTPEVIRLFAKKQPGQLRQRLTDLQRDVKLGKLAEPDFQQQSVEILVALRNLGEQLSPAEVEFLNKHSSGSLNNFEKVSSDLAGDKVLSAAGSQVATARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3X1</accession>
    <name>A0A0D2X3X1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270560.1">
        <property type="nucleotide sequence ID" value="XM_011272258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3X1"/>
    <dbReference type="STRING" id="595528.A0A0D2X3X1"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3X1"/>
    <dbReference type="OMA" id="CPPCAPI"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3X1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26113" checksum="511884480AA9468C" modified="2015-04-29" version="1">MTYAVTKNSLKALNVFYLVVSIILIAVAGAAKGMAKLSSAAVAGGVIACGVFLLLVSVLGFIGAHKHHQVMLFIYMIVLALIFIIQFSVSVACLSVTGGQQRDLVREAWIQLSADSRADIQNWGTCCGFDAPTGAYYNGTVFTANYLGPSENVHTNPHQRCPCSDGSNSAATGNLVCHDDGSGTEGTPGSGYPTRGPKGKGCMAKLEDDLDKGFKAAGGVGLFFSFTELIGIVAAARFRTSLKQEANYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A8</accession>
    <name>A0A0D2X4A8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4A8"/>
    <dbReference type="STRING" id="595528.A0A0D2X4A8"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4A8"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="37"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="205" mass="20739" checksum="4259E5822D4A6DAA" modified="2015-04-29" version="1">MTSDWFAAVVSVREDVMAMNMNTPTFDDAPPSPRASETVLQALNAKANKKPSVANLSLGGSKSTAMNTAMDNLVKAGVFAAVAAGNENQNACNVSPASAPLATTTGATTIKDARASFSNFGTCVDVFAPGQDITSTWIGSTTATNTISGTSMASPAVAGVAAAILSANLAWTPAQVEAELLATTTLDVVTNSGTGSPNKLLYLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4L5</accession>
    <name>A0A0D2X4L5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4L5"/>
    <dbReference type="InParanoid" id="A0A0D2X4L5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37520" checksum="D1F934E070CBDC11" modified="2015-04-29" version="1">MVFTTTLPLTPTHGGIDVCLLDTAGKIAEVVALFKSNAVTTIAVDIEGRNLGRGGLIATIQLHAPESPTTVYVVDVVAVGATQTFSHETGLAKVIQGLSTSYLSYAARNRMDLNKREAQRLFAPEQGGSYDVWFTRPLSAILIEYLTDVHIFSHLLTALLPEDQRAIHRPAIERASSRRLNIAHALDFSKDNSRNKLVDDEPFIDEIVSNCSSSVRTRISNERAELLRIQALPVKDRVRTRGGGPSAMQEVSEALRGHRTIQPVILWDVVQFICAHNRWFSSEDYMAFLELAMSSYYLTIKQRQTCSDWRSRNGAHKNQRYTDDECYDYDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4X3</accession>
    <name>A0A0D2X4X3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4X3"/>
    <dbReference type="STRING" id="595528.A0A0D2X4X3"/>
    <dbReference type="InParanoid" id="A0A0D2X4X3"/>
    <dbReference type="OrthoDB" id="2273864at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4X3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="29725" checksum="7F6DE27C69521B9B" modified="2015-04-29" version="1">MFPEKLLIAVMSDDFLSRVRQALATDILALEIAEDPSRFPKFTTKDDLLYFKSALYIPDSADLRSLVLESRHDSYAAGHFGIRKTIELVQRDYYWPKMHDTIQHYPLPIAEHPWKSISMDFITQLPPSNSFDAICVVVDRLTKMAHFMPCTTRINALGTADLLIRRVFLYHGLPDDIVSDRGSVFVSHLWNHLFTSLNTKINLSTAYHPQSDGQTEAINRILEQYLRCFISAGQDNWSDLLHLAEFAYNSSVQSSTVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X543</accession>
    <name>A0A0D2X543_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X543"/>
    <dbReference type="STRING" id="595528.A0A0D2X543"/>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X543"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X543"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="58708" checksum="399E6E4C2021113E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5A6</accession>
    <name>A0A0D2X5A6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343187.1">
        <property type="nucleotide sequence ID" value="XM_004343137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5A6"/>
    <dbReference type="FunCoup" id="A0A0D2X5A6">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5A6"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5A6"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5A6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="37"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="624"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="727" mass="79839" checksum="34D3F39EE208FA7C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0X3</accession>
    <name>A0A0D2U0X3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365330.2">
        <property type="nucleotide sequence ID" value="XM_004365273.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0X3"/>
    <dbReference type="STRING" id="595528.A0A0D2U0X3"/>
    <dbReference type="eggNOG" id="KOG0992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0X3"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0X3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="812"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1213" mass="129601" checksum="6188F8108B5AC22F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2T2</accession>
    <name>A0A0D2U2T2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365823.1">
        <property type="nucleotide sequence ID" value="XM_004365766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2T2"/>
    <dbReference type="FunCoup" id="A0A0D2U2T2">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U2T2"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2T2"/>
    <dbReference type="OMA" id="DDNDTMI"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2T2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23240" checksum="89B03664092B9773" modified="2015-04-29" version="1">MVKENERYLPKAVRSMRDILRAMGAEQYDERVIQQLLEFMHRYVASVNDEAKRYAAHASRDRINVDDVRLAASTVVSTGFVTPPPREFLAELAAQRNQFQLPTIRDHVHGLRLPPEKYTLSNVNYQVDPTLAAPLPSAELQAPLPPILGVVGVGVPMPAIRVAMPGVMMPGAPLADAMDTEPAGSQSTAQLEDSLSRKRKAEEEPEEFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4U4</accession>
    <name>A0A0D2U4U4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364376.2">
        <property type="nucleotide sequence ID" value="XM_004364319.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4U4"/>
    <dbReference type="FunCoup" id="A0A0D2U4U4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4U4"/>
    <dbReference type="eggNOG" id="ENOG502S0MC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4U4"/>
    <dbReference type="OrthoDB" id="5803434at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4U4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="29423" checksum="556CBF9EA12CB9F2" modified="2015-04-29" version="1">MDMMRRGYVLTKSLGVGHSDLNLAISDEKAVHSGLVNLAKARTAAATALVKWTTQEDNPAIRDIFARLAELDNEHNAVQKEFSDRYEDYRRCFKAVRDSEKTLDRARKHRDDCATKLQKLHRDLERYNRKGDYGKVSTVESEIIAAEQANDVAEAEFQEKYRECEIIKVAKIKEGLSNVANAYIEMAEKMVLVFSATKDLASVLPDEPAHLTTEPVYEGGEAYSEEIVQSARRALQEYQPQTPYSNSNAYANDEYEDDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5H5</accession>
    <name>A0A0D2U5H5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5H5"/>
    <dbReference type="InParanoid" id="A0A0D2U5H5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="624" mass="67628" checksum="9F1423E47E42503D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U637</accession>
    <name>A0A0D2U637_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364750.1">
        <property type="nucleotide sequence ID" value="XM_004364693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U637"/>
    <dbReference type="FunCoup" id="A0A0D2U637">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U637"/>
    <dbReference type="InParanoid" id="A0A0D2U637"/>
    <dbReference type="OMA" id="ANMSTWE"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U637"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="25008" checksum="E03CAEDF7FAD1163" modified="2015-04-29" version="1">MLNTSSNDHLLDSRANAAYNSITQSELRNMRSELVRAGVVGSAWTVAATSGAIFALSRLSPAIARTTIPSRVFVVTMLSTGVGVSCAERRMLAFRSESRAAKAAALSANTVNNPVLAKRLQEHENLANMSTWEAVRTMDWNRWLIVNKFYVIGGIWAASMVGSLALSFRNPNIKPSQKLIHARVYAQGLTVAAVVASAAVAPFDHKGDQEEKDAMDLLRYEAMGEPSAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8L1</accession>
    <name>A0A0D2U8L1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270218.1">
        <property type="nucleotide sequence ID" value="XM_011271916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8L1"/>
    <dbReference type="eggNOG" id="ENOG502SVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8L1"/>
    <dbReference type="OrthoDB" id="40547at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="325" mass="35367" checksum="9B8622CD8D588E16" modified="2015-04-29" version="1">MARVHLVPLTSFDEILGLWTRVLLEEPIGTEADTTTQVFWLQTRTLFADIRIPVPNKISGSAAAAAGRLYEQIARQKGFAGVTAITPADTDNGTPGQITWNRTIDYQPPTGMADVGYASFTTQTKDTLIEYGLEGDDYKEIWKRVDCSAEGLANQHMLAMTLESEAIASKSNDETFVNQPSVQGILVGAGDRFISCVDSPRQAALSQNNAPLTFSTAAAFLEAARNTTTATLGDSTTLGNLESSRAALFGVDIALFSSRRLLLSTRADSTLPTEELFLEMVGTFKLVDDSTVVQSLTTQAGERIRRIWRVQENSYPQFPLSTLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHZ5</accession>
    <name>A0A0D2UHZ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270532.1">
        <property type="nucleotide sequence ID" value="XM_011272230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHZ5"/>
    <dbReference type="STRING" id="595528.A0A0D2UHZ5"/>
    <dbReference type="InParanoid" id="A0A0D2UHZ5"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="449" mass="45417" checksum="C83118E5E3CE7F75" modified="2015-04-29" version="1" fragment="single">MAAPTPIEIANQFVHLYFTYLNRDAMQLHRFYKHNSSFTHAEESQSSDQQTYVGVEAIKNKIESLNFNDPRAVVLRIDAHQTVGDGVLVLVTGTLFINSLPRRFAQTFLLAPQQNGFYLHNDVFRFLKEDDAVDVVAAAAAAPAPVAAPAPAPVAAPVEHKAPEPVAAAPAPVAAAPVAAAPAAAAAPAPVAAAAPAPARVAEQPKAAAAAAAAPAEQKPAPSGQQQRRRPAPAAAGAATTAAAPAAEKPAPVKPTSYAGMAAQPAAKPKAEKPAAPAAAPAAAAAPVAAAAAAPAAAAPVAAAATAAAPVAAAATPAAATNGTERPPRTQAPRAAPGSSLFVKSVPENTTQADLTAAFASVAGFKSVSAPNAKGNFFVDFDTPENATAARTTGVSVKNVPLALEEKREQRRDAPRGDDRRPRGDGARNGPRDSAPREGGRGRSFPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI13</accession>
    <name>A0A0D2UI13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Appr-1-p processing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI13"/>
    <dbReference type="STRING" id="595528.A0A0D2UI13"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI13"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UI13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF121">
        <property type="entry name" value="ADP-RIBOSE 1''-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="53"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="262"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="551" mass="60769" checksum="CFD8EA90E089DD57" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIU6</accession>
    <name>A0A0D2UIU6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein transporter Sec24-like CEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UIU6">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UIU6"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UIU6"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UIU6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="657"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="732"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="1227"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="450"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1361" mass="147073" checksum="976D7A438084EACC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKV2</accession>
    <name>A0A0D2UKV2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345716.1">
        <property type="nucleotide sequence ID" value="XM_004345666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKV2"/>
    <dbReference type="InParanoid" id="A0A0D2UKV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="226" mass="25611" checksum="FD8C915880718D16" modified="2015-04-29" version="1">MSVNLKQIYRDLEDLIERVRGGEFSETTTLRSEISYITEGIVDVYKAVQQNKKAIERHEELLRQEQAQLENLRRKREAAHRKVQQTEQHRPRHATAQRSPAVTREQLRALPVVSGVVIEEVTDLYDSPSAAPAPEPMPIIPLPAPTYASQLNQDEINGIDTFVAHPSGYNFLDLAIRTNAPDYTLLPAEMHTTAQLICGSQNYIGYAIESAANRQLYYEQPLQLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL24</accession>
    <name>A0A0D2UL24_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345801.1">
        <property type="nucleotide sequence ID" value="XM_004345751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL24"/>
    <dbReference type="STRING" id="595528.A0A0D2UL24"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UL24"/>
    <dbReference type="OMA" id="NTIRMAR"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UL24"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="3"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="311"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE95796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="464" mass="50585" checksum="FE91D854C249A4DE" modified="2015-04-29" version="1">MPVGILGDLCGPKVRVGVFVDRQPIQLVQGKHIRVRSGDEPGSVTCLTTTTAAVVRQLEVGNTLLLDDGNFRLRMTERIGEDEIECLIEVGGLLKEKKGINVPELRLALSAFTEKDRRDAQFILEQKLDFVALSFVQRAADILELTSFIDDFNRSKEERDRVHPEIIAKIEKPHALDDIDEIIAAHPSVNIMVARGDLGVEASFERVPTAQKMLIAKANAAGRAVITATQMLETMMNSPVPTRAEVSDVANAVFDGTDAVMLSGETAAGKYPLETVRMMASICLHAETQHTILARMVAEVDTSEGGFSFDDAIADASVASARKAEAVAIIVLTVSGKMAVRVSKRKPTQLIIAMTQSWQVANQLNLLWGVHPLILGKFSDTDGALLECERALRAREWVRENDTLVVCSGANEFHTGLSNTLKLHSFGHASRAMTARAHWKDALGVLQHKGRVHSPAIDSDPNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULU9</accession>
    <name>A0A0D2ULU9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345182.1">
        <property type="nucleotide sequence ID" value="XM_004345132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULU9"/>
    <dbReference type="STRING" id="595528.A0A0D2ULU9"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULU9"/>
    <dbReference type="OMA" id="YVTMFLI"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="334" mass="36859" checksum="1086C6A48E8A6DCE" modified="2015-04-29" version="1">MRFSEYAGTNRLSCRGKGVTGPNRNVLYITLALMVVIYGVFLAFPARYLYYSLSKSIPFVGSYIFLQAFVLLIATALKDPGILPRARVPEREDPMAPLYKDINVNGIDIKLKYCVTCNFFRPPRANHCSICNNCIEGFDHHCPWIANCIGRRNYRMFFGFVLFITLLTIWVLAFSIVHIVQAANDGVFQEAAASVIVGLFAFVALWPVLMLLNFHARLVRLNLTTNEDITEKYVKTGNPFDQGCAKNCASVLCAPRFPRFIKPVQPQEVELTKVTATSAVAGSAPSASDAAGVQMEQRSPSAPPSESAQVGEVYDNALRSETNHDSTVVNVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNN3</accession>
    <name>A0A0D2UNN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rbm17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNN3"/>
    <dbReference type="STRING" id="595528.A0A0D2UNN3"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNN3"/>
    <dbReference type="OMA" id="LTHHTTH"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="614" mass="63610" checksum="AFD439B3A502537D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNV1</accession>
    <name>A0A0D2UNV1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNV1"/>
    <dbReference type="STRING" id="595528.A0A0D2UNV1"/>
    <dbReference type="eggNOG" id="ENOG502S2MD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNV1"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="240"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="518" mass="56451" checksum="62490EB6FEF2FA33" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPE7</accession>
    <name>A0A0D2UPE7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPE7"/>
    <dbReference type="InParanoid" id="A0A0D2UPE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252804" description="PSI domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14841" checksum="CC7C9C53A287CAB2" modified="2015-04-29" version="1">MSRSSSIALFVLSIVIAFGIASASSSLDPCLNGYGSTTALISNCSTCIDLSGCLWCASPSLTSGNSKYISPEGLCISGDWRGLGEQVCFSCSDWRYGECAISSVVLYGLCGGAVALVLIAITITVICVRRRRRSTAYMIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPJ1</accession>
    <name>A0A0D2UPJ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golvesin/Xly CBD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPJ1"/>
    <dbReference type="InParanoid" id="A0A0D2UPJ1"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPJ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.40">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033803">
        <property type="entry name" value="CBD-like_Golvesin-Xly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25275">
        <property type="entry name" value="Golvesin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253650" description="Golvesin/Xly CBD-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Golvesin/Xly CBD-like" evidence="3">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1074" mass="111140" checksum="402F1AF6008DD437" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ58</accession>
    <name>A0A0D2UQ58_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270764.1">
        <property type="nucleotide sequence ID" value="XM_011272462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ58"/>
    <dbReference type="InParanoid" id="A0A0D2UQ58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="144" mass="15684" checksum="76492CF673470BBA" modified="2015-04-29" version="1" fragment="single">VVANILQIVDMIKSPPIGIPEVMRIISRFLFVFTGLLLTLALCSLSIMEDWFRFLVDWRGFGLALMYLGVVSFAACADSPPLSQSRETARQVACWITIAVGGFYFVLGLGGGARLKLRKTSQIYGAPLHDGPAVISATTPDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US27</accession>
    <name>A0A0D2US27_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase 2</fullName>
            <shortName evidence="11">MAP 2</shortName>
            <shortName evidence="11">MetAP 2</shortName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007874</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342959.2">
        <property type="nucleotide sequence ID" value="XM_004342909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US27"/>
    <dbReference type="FunCoup" id="A0A0D2US27">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2US27"/>
    <dbReference type="InParanoid" id="A0A0D2US27"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2US27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="14">
        <location>
            <begin position="209"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="55775" checksum="B5FF224F311230E5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US79</accession>
    <name>A0A0D2US79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343000.2">
        <property type="nucleotide sequence ID" value="XM_004342950.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US79"/>
    <dbReference type="STRING" id="595528.A0A0D2US79"/>
    <dbReference type="eggNOG" id="KOG0033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2US79"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2US79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="525" mass="58944" checksum="6C11D0D8A19C0590" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT65</accession>
    <name>A0A0D2UT65_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_008157</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342758.1">
        <property type="nucleotide sequence ID" value="XM_004342709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT65"/>
    <dbReference type="FunCoup" id="A0A0D2UT65">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UT65"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UT65"/>
    <dbReference type="OMA" id="WNICRID"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT65"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000577">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="209"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="632"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="485"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE98146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="835" mass="92551" checksum="DC7A172283B43724" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFQ4</accession>
    <name>A0A0D2VFQ4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365077.2">
        <property type="nucleotide sequence ID" value="XM_004365020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFQ4"/>
    <dbReference type="STRING" id="595528.A0A0D2VFQ4"/>
    <dbReference type="eggNOG" id="KOG0167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFQ4"/>
    <dbReference type="OrthoDB" id="424220at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="2">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="302" mass="31786" checksum="421D4100C7D045CB" modified="2015-04-29" version="1">MPPSKSKKNGSTSDDSDDFGIFAVAGIALAAGALIGAGLKAVYDSVTAAPEPAHQSQHALSEVLEAFNCPITQEVMSDPVSTPYGHCFERDAIERWLQTHKTCPMTKKPLTQAQLFPNYTVKAAIESALASSTSSSLPCSSSASASGAERVPRVADDAVQVTLAPEALRAGLRCLDPDTVRALCTGANWNPAMAESVFLLLDALPTSNQSVPFAVTNRGTVPLVLVAQRHRPFASSNVHDDDGRETGRLTLAPQQSARLAISSTWRLNVQLPTQDGLPKTVLLAVDEAAALDGSPSSLPMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFW0</accession>
    <name>A0A0D2VFW0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FR47-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365124.1">
        <property type="nucleotide sequence ID" value="XM_004365067.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFW0"/>
    <dbReference type="STRING" id="595528.A0A0D2VFW0"/>
    <dbReference type="InParanoid" id="A0A0D2VFW0"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFW0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF1">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="36126" checksum="B2809810B24C278B" modified="2015-04-29" version="1">MFREITADAELEAMERHCLEHRGHYGLRMGYVLHNARRGRVPTARFYADLGDVTAGRFAAAAHGAGTTEPGSSPTSAASPKSGGESAACTMIIMVHPTADEDTIALDATTPEAARVLIHEHLTNFTLLGIAHPSNPQRPRRSITFSGFDDAHFTENIRQVFPQESGFVLKYHPCKMYSATNPALFAPELYLPKLQAGWTLGPLRAEDAPMVNQLWPYSSPGTLGFIADLITTYPSMCLFVDGTPACWCLTQNYGAMGMLHTKDEFKRQGLGKIVMMALSQHLHSKNHVPFLYVVHPNTASHGLFKSLNFPQEDRDQSWLLVHPPKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG09</accession>
    <name>A0A0D2VG09_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000322</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG09"/>
    <dbReference type="FunCoup" id="A0A0D2VG09">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VG09"/>
    <dbReference type="InParanoid" id="A0A0D2VG09"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG09"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="579"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="944" mass="104500" checksum="A4AF18291F3160C1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH79</accession>
    <name>A0A0D2VH79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH79"/>
    <dbReference type="STRING" id="595528.A0A0D2VH79"/>
    <dbReference type="eggNOG" id="KOG2152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH79"/>
    <dbReference type="OMA" id="KSMQCVI"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="416"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1158" mass="121416" checksum="A6F00EC1FD7F059E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI66</accession>
    <name>A0A0D2VI66_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase iron-sulfur protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365913.1">
        <property type="nucleotide sequence ID" value="XM_004365856.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI66"/>
    <dbReference type="STRING" id="595528.A0A0D2VI66"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI66"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="202"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="472" mass="52827" checksum="37BBBDEBA8476A6E" modified="2015-04-29" version="1">MLSLLRPALARTVASRMASTSAPAAAAAAAVAVTPALPQMRGAVEPAAAVSKKIGEWKPTVYSPPQTFYPPLADTEAAPYVPERHVSNYTMNFGPQHPAAHGVLRLVLELDGEVVHRADPHIGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMANEQAYSLAVEKLLNIQAPPRAQYIRVLFGEITRLLNHIMAVTTHAMDVGALTPFLWMFEEREKMMEFYERASGARLHAAYVRPGGVALDLPLGLMEDIYNFIKPFSSRIDEMEDMLTENRIWKQRLVDIGIVTARQALDWGFSGVMLRGSGIAWDLRKVQPYDGYEKFKFDVPVGKRGDSYDRYLCRVEEMRQSIRIIMQALNDMPTGEVRIDDNKITPPRRAEMKESMEALIHHFKLFTEGYVVPAGATYTAVEAPKGEFGVYLVSDGSSRPYRCKIRAPGFAHLAGLDFMSRGHMIADVVALIGTQDIVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJL4</accession>
    <name>A0A0D2VJL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364377.1">
        <property type="nucleotide sequence ID" value="XM_004364320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJL4"/>
    <dbReference type="FunCoup" id="A0A0D2VJL4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJL4"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJL4"/>
    <dbReference type="OMA" id="PDETFHC"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="336" mass="36887" checksum="D4126B6EEE87FCDD" modified="2015-04-29" version="1">MSHNTTGPLVTVNGHKFQLPADEQALEHAVRSFPWMTYRNHFAQIADSYYNTDAGWGCMLRCGQMLLARAMTVQHLGKNWAPTSRKQRHQEMARFLPLFFDTPAAPFSIHRIAERGEALGKTIGQWFGPNTVAQVLKNLVNSQRSSLIVHCAMDGVLNRTEASTQLAAALSDGKKHSLLVLVPIRLGLNQSINPVYIPALKATLELPQCLGIIGGKPNAAHFFVGTVNENVLYLDPHVVQDAAMELTPDTVESFSVAVLSKMAISDVDPSMCAAYLCSSVAELEDLGKRSKQITSQFRGYGLFDVIEDSRINSLSLDSMAVDSDDGSDEDDFDMCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJR9</accession>
    <name>A0A0D2VJR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJR9"/>
    <dbReference type="STRING" id="595528.A0A0D2VJR9"/>
    <dbReference type="InParanoid" id="A0A0D2VJR9"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJR9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39373" checksum="09E5C4CC2CE44323" modified="2015-04-29" version="1">MPVITLVEDQMTENQKLWYMQAKDAIQDQNWTEMGLCDEEAEAIALGLMANTNLLQLELDGNGIGERGAKCLAEALENNRTLKTLSLKKNQIGDKGAIALAEALKHGSTLTSLNLNSNMITTTGLMALADCLSVNSQLKELFLDWNHIDCQGARALAKALATNTSLRRLDLEANLIRLDGGIAIAKSLESNSALEVLNLKGNRVGSTGTSAFATALKVNRKLCKLNLSSNDVGSRGAKALGLSLKSNIGLTELSLSDNEIDDEVVKVLKTNLMLYPTLKTLDLTGNPKISTTTAQANANTAQPVIEVESQEDQPQDEQQPQGDQTQTIAVLTSAAVDPQDEQPELDKQDVDNDDDDEEADSDASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKM3</accession>
    <name>A0A0D2VKM3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364743.1">
        <property type="nucleotide sequence ID" value="XM_004364686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKM3"/>
    <dbReference type="STRING" id="595528.A0A0D2VKM3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKM3"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="392"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="67781" checksum="EF209638AB469FCE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM98</accession>
    <name>A0A0D2VM98_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM98"/>
    <dbReference type="STRING" id="595528.A0A0D2VM98"/>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM98"/>
    <dbReference type="OMA" id="HYMTDVE"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="3">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="84243" checksum="B9719F60CEB276D7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMF9</accession>
    <name>A0A0D2VMF9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMF9"/>
    <dbReference type="InParanoid" id="A0A0D2VMF9"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMF9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="807" mass="87047" checksum="873FB82FA1730C89" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMW7</accession>
    <name>A0A0D2VMW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349422.2">
        <property type="nucleotide sequence ID" value="XM_004349372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMW7"/>
    <dbReference type="STRING" id="595528.A0A0D2VMW7"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMW7"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="300"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="388" mass="40922" checksum="A6B233DBD880C94F" modified="2015-04-29" version="1">MGNSGSQQQPQQQSSSSSSSSRYGQPAQHAPTSRKTSDPSAMSPRMGRPMTAASPMQTSSNSSNNNNGNRVGSSSSGGSGGGGSSVPLHPGSTGSNGSVGSRGQDGGAVVSGGRQLVNNQRLGYFEAPSPPAFGSPLDTPSFLDFPYGPAGSGMSGSHDGRGGSNNGNGGAIPDPVSVAMLMEDDLANAGTPLRGSSANARREGVPTVFRWHRGGKNVYVTGTFNGWKGRIPLNKSHDEFTTIVELPPGTHQYKFIVDDEWMFNPDQPTVPDPYGAMNNMVDVLPPDSMYEIESDPTALSSSPPGDYGQEMPPMEYGAKPPPVLPPHLLQVILNADPVSEDDPTRLPVPNHVMLNHLYALSIKDGVMVLGVTHRFRKKYITTVLYRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN57</accession>
    <name>A0A0D2VN57_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN57"/>
    <dbReference type="FunCoup" id="A0A0D2VN57">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VN57"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN57"/>
    <dbReference type="OMA" id="AMQINFA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN57"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="28996" checksum="C58D2B23CC114C73" modified="2015-04-29" version="1">MEVDHQQQQQQQQQQQSSIPPSQTLYVNNLNEKLKKEELRAALYTIFTQFGPVLDIVALKTLKMRGQAFIVFHDITSSANALRSLQGFSFYGKPMRITFAKSRSYAVGRFNGEPDSHVRRPFIPKNQRPKGEKQPGKRNPNGAAAASSNGDAQAMNTEAPAAAGNHAPMLQQQQPGFGFSQAPEIPHNILFVQNLPQGITQDDIFNLFRGYTAGSCDVRLVPNRADIAFVEYENEGIAANAKATLHGYKMGDNNLSVTFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN84</accession>
    <name>A0A0D2VN84_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348640.1">
        <property type="nucleotide sequence ID" value="XM_004348590.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN84"/>
    <dbReference type="STRING" id="595528.A0A0D2VN84"/>
    <dbReference type="eggNOG" id="KOG2821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN84"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="2">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="498" mass="53356" checksum="851110F7E16C9994" modified="2015-04-29" version="1">MAAAAATATTIDELKRLAAKIDTTLQPQPPATTTAEAQSSLHTQARGLVASKHAVSSASSSPANQANRTTLAVRPAQSQSQAQPQPQAQSQAQAQVDYVVLTGIIAQLEKTTVDTETLRQTGIGKRVNAIRKHCAARLETLSKGANRHVKPDLVCQQLQTRAASLVERWRKAVELGEAATAPNNRAAVPPSSHHATGPSPTTKRPNEASTDTPPTKKLRYDDPNPPAAAATPSASLLRIAAPPPSAAAESPFANIPASLMPSAPASSRTPSLAPHSSAARHDPFARSGGRSESTHHHTVTSTVHRAIPSLTAMCQHVIATHLERFTSFGNLLPLDALLPALQRCTPRQLVRVELNNVDLVGSTDDIWKRLTESTFPGVAPQPNTSWRETFFAQQRFNDSKVDRIGARLRALKESSALQQQQHAVQQLKAPANGGFGTRSPTQLYSITAAMNQTHRPATQRPAGSVRAPMSDAQIKLNKTKRTIAQAVIREQAYTPMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNA4</accession>
    <name>A0A0D2VNA4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363696.1">
        <property type="nucleotide sequence ID" value="XM_004363639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNA4"/>
    <dbReference type="STRING" id="595528.A0A0D2VNA4"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNA4"/>
    <dbReference type="OMA" id="HCHHEER"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="180"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="300"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="476"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="850"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="910"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="921"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="954"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="968" mass="106904" checksum="858ADCF08C3E9359" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNL3</accession>
    <name>A0A0D2VNL3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2-aminoethyl)phosphonate + pyruvate = phosphonoacetaldehyde + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:17021"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57418"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="2.6.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNL3"/>
    <dbReference type="STRING" id="595528.A0A0D2VNL3"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNL3"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNL3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010006">
        <property type="entry name" value="PRK13479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02326">
        <property type="entry name" value="transamin_PhnW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42778">
        <property type="entry name" value="2-AMINOETHYLPHOSPHONATE--PYRUVATE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42778:SF1">
        <property type="entry name" value="2-AMINOETHYLPHOSPHONATE--PYRUVATE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="68"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="420" mass="45858" checksum="44BE97FCAFD0935A" modified="2015-04-29" version="1">MVEILAAADAAGTSAKHTVLADRIAGIPTDAEAAANFPAKFLGFELAKDKPLFTPGPLGVSLTTKQAALRDLGSRDRLFMDTVKDIRTQLVQLAGVSTKDFTSVLIQGSGSFAVEAVIQTALPRKGGKFLVLANGAYGYRMNKMANYLDIPVIMFEFPETEKAPLAEVEKLLKANPDVTTVAIVHSETSSGIINPISEVGALVRKHLPNATYFVDAMSSFGGIPINMEEANIDFLVSSANKCIEGTPGFSYAIARRSALDKCKGNSRSLSLDLQDQNAYMEQTGQFRFTPATHSILSFRQALRELEIEGGVEARAARYQLNRAILRKGMAELGFRELLDNSHEGYIITSFHFPKHAKFDFEKFYSTLSAKGYVIYPGKVTKADCFRVGSIGRLFPNHMTELLETMKVVLAEMGIPTPIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNQ2</accession>
    <name>A0A0D2VNQ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363863.2">
        <property type="nucleotide sequence ID" value="XM_004363806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNQ2"/>
    <dbReference type="STRING" id="595528.A0A0D2VNQ2"/>
    <dbReference type="eggNOG" id="ENOG502RZNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNQ2"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNQ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="28491" checksum="D2E5D3B0246D6F7A" modified="2015-04-29" version="1">MPVQSLVQNKMDVSSYSYDPLASSTLSTRSTSSLSQSQIFTAQQASGAPGASGASGASASGATATSAASASSSLQQQQLIQLAAATSLASTFDTLDLSGSVNDASSGFLQLLVPQLSAVAAQLAELQLGQELLLQTIRDESEGFKSLPDLQNITDTIAKIPAYQLKLVNFRREMLSMHERMARLKKRATKLKERRIEEDNKTSVQKAKEQEKEKALMAKPSDALLTVQDDTPAAVVAIPAATAAPSSSSTERKHAATASIAPAPKEPTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPA0</accession>
    <name>A0A0D2VPA0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270293.1">
        <property type="nucleotide sequence ID" value="XM_011271991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPA0"/>
    <dbReference type="STRING" id="595528.A0A0D2VPA0"/>
    <dbReference type="eggNOG" id="KOG0352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPA0"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPA0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="606" mass="65266" checksum="C630B4DB72D3723A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTQ7</accession>
    <name>A0A0D2VTQ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_005285</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346970.2">
        <property type="nucleotide sequence ID" value="XM_004346920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTQ7"/>
    <dbReference type="FunCoup" id="A0A0D2VTQ7">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTQ7"/>
    <dbReference type="InParanoid" id="A0A0D2VTQ7"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTQ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11030:FF:000001">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="17">
        <location>
            <begin position="69"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE94672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="418" mass="44059" checksum="6F29A59CD6FC3CE8" modified="2015-04-29" version="1">MSAAQHCVIARSFLHCLTRSIHRPPSSRFTMSASNSSSSSSSGSSSGSSSSSHTQLWTISPDQPYAAIYEQVAGAAALLAADEAVVIPTETVYGLAANAFSDDAVAKIFRAKNRPADNPLIVHVADESQLREVVEGEISQREQQLIAAFWPGPLTLILPRKISVSRLVTAGLTTVGVRMPSHPVAKAIIARCGKPLAAPSANISGRPSPTCGAHVIGDMMGKVAGIVDGGATGVGVESTVIDCSPEIPIILRPGGITKEEIETIIGPVTYAQELHSNERPESAKDVSALSGHVPRAPGMKYAHYAPKAPVTVVEGSPQFLQSLVDAHHQQHPTSKIGVLATDESRGQYRADVVVTCGARSDVASIARSLYDALRQFDIATPSVDCIYSESFSTDGLGAAVMNRLLKAASHQVVREHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXM6</accession>
    <name>A0A0D2VXM6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXM6"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="122" mass="13100" checksum="673298C2D05BA0E1" modified="2015-04-29" version="1">MTQRLHERRNAAAATTDAATASSHNNHHGHPHSHAHAHHHQSHHSAAAHGRHDMQADHPSPAVFTPPAFSDHHAANHADRGWGNFGGPHLRSHGLTPGASGHHETSNLLSIPVVEISEIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXN7</accession>
    <name>A0A0D2VXN7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344384.1">
        <property type="nucleotide sequence ID" value="XM_004344334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXN7"/>
    <dbReference type="InParanoid" id="A0A0D2VXN7"/>
    <dbReference type="OMA" id="IMHDERE"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657:SF1">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32077" checksum="52982B3424774BBF" modified="2015-04-29" version="1">MGRPDGRGGGRGRGGSFSRGGGRGGSRGAGRGGGGFRGGASRGGGGGRPQPMFGRGGSRGGAGVGKSQQQFVTATAARRSAMEQRTVTAYKKLLRKEGRPTTQTLRGEEREAEKDVELDRKQRQDKYAERDAQAVVNAERERARAALAAVHGGDLNDDDDEDEDLDGSARGSRSLKNDNQEVDDDRDDDNEDDDDTRTTIGGKHQRHSDRAAVPVGFAKERAQFEQDKLEREAAFAERQRERAEREQRIKEQRHKRRETTSLMKQRTKRGQPVLHNQVNGLLDKIIKMRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYN3</accession>
    <name>A0A0D2VYN3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343832.1">
        <property type="nucleotide sequence ID" value="XM_004343782.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYN3"/>
    <dbReference type="STRING" id="595528.A0A0D2VYN3"/>
    <dbReference type="eggNOG" id="ENOG502QQPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYN3"/>
    <dbReference type="OMA" id="WTTPWTH"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="344" mass="36890" checksum="F30DE6D2A873FD52" modified="2015-04-29" version="1">MLSQCVRQSSRCTRLAAATLPIRHFGASVAPAAPAAPSATPASGFAVREERLRRTLFNGKSFIETPKNHAFVLPGSDERKIAKASTLTADSIVLDLEDGVARNRKAEARKLVLNALNSVASASTMSAQASLAVEDLTAVLQSPKLQGIVIPKVEYASDVLFVSEFINSVAPASSRGEIRLLAAIESAVGLLNLREIAASCPRLDALIFASEDLCADMGITRTAGARELLFARSSTVVHAVAHRLQAIDMVCMEFKDNQRLSQECEEGFEMGFTGKQAIHPNQIPIVNDKFRPPASAIKKATRILEGYKAVTDKGVGAFDLDGQVIDLPVVKWAEKVLARAGIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZS9</accession>
    <name>A0A0D2VZS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343112.2">
        <property type="nucleotide sequence ID" value="XM_004343062.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZS9"/>
    <dbReference type="FunCoup" id="A0A0D2VZS9">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZS9"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZS9"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZS9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="550"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1081" mass="121116" checksum="33CA7C1CD1B25363" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0N9</accession>
    <name>A0A0D2W0N9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0N9"/>
    <dbReference type="InParanoid" id="A0A0D2W0N9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="118" mass="13350" checksum="FFA7BC725F000485" modified="2015-04-29" version="1">MTCASLAFSSAVCEQQCTARVDRTSSSFAFVAFVVVVCRHANDMRQPDYNFQIHFFFKNQSSQWRCEKKQRFGSPTNGAQLSKLGKYEHSRTPGHASVVTESLQLTSCPFSYRFTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W114</accession>
    <name>A0A0D2W114_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342614.1">
        <property type="nucleotide sequence ID" value="XM_004342565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W114"/>
    <dbReference type="STRING" id="595528.A0A0D2W114"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W114"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="452"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="518" mass="57104" checksum="3FA93556CE858CD2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHR0</accession>
    <name>A0A0D2WHR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHR0"/>
    <dbReference type="STRING" id="595528.A0A0D2WHR0"/>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHR0"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="854"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="357"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1267" mass="132687" checksum="C910B02250ECB584" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHS0</accession>
    <name>A0A0D2WHS0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHS0"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHS0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="42455" checksum="AF67832488AC3C61" modified="2015-04-29" version="1">MPCSGDIPVRSIPSFGGKVTDTLKTVGIETGGDVLRAPPSFLASLFGASSPTPASLLRACRGEDDSEVVDRGLIKSISSQMALTAWARPRFGGGPTATIEPVGVSEDISLFIRELAEDLAERTLEDQIVHSRHPSTLTVAYRVDDTWSRSRTFPFPLQAMNMVEISVSELTLGPVVLRPALSSAAKTARRPLPTSPTSEAPETTANAGVPTPFAFPGFEEFVAKITKLGVDAYTASLDVGDVGNLTSLSLSALNFLPDTNLITNFFGKTREPAAAAVGVAREPAAAAVDVARRSNSVASHQRGDALFRPSSSKPTDGNASAAVDLTSAQLLHSAQVSRSCDDNPRAAVLVRESANVGESSAAPMPIRASVRRLWEEDAVQSERLSQHSFFKRLAMNARVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WID4</accession>
    <name>A0A0D2WID4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Recombining binding protein suppressor of hairless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270035.1">
        <property type="nucleotide sequence ID" value="XM_011271733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WID4"/>
    <dbReference type="STRING" id="595528.A0A0D2WID4"/>
    <dbReference type="eggNOG" id="KOG3743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WID4"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WID4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="377"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="498"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="85226" checksum="E412F47EE8163243" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WII3</accession>
    <name>A0A0D2WII3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365304.2">
        <property type="nucleotide sequence ID" value="XM_004365247.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WII3"/>
    <dbReference type="STRING" id="595528.A0A0D2WII3"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WII3"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="830"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1014"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1261" mass="129462" checksum="6269CD3280C90BAD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIJ4</accession>
    <name>A0A0D2WIJ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 member 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365322.2">
        <property type="nucleotide sequence ID" value="XM_004365265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIJ4"/>
    <dbReference type="FunCoup" id="A0A0D2WIJ4">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIJ4"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIJ4"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIJ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="73"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="171"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="350"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="440" mass="47018" checksum="A00E2F142B96EEE9" modified="2015-04-29" version="1">MEGAAASSSPRPPQSPLAVPYHARSGLGLLLPSAREQQDTRQGRVTATGSSSTATNATSAHLAATTPGSRPPPPAWAHMLGGGLGGTLGTVATSPLEIIKTRMQSSQHRSDPRAPRTIRTALLQLYRVEGPRALFRGLVPNLVGVAPSRSIYFFSYSKGKEWVSALVDDKSSLVVPAGGAILAGVSASTITNPIWLVKTRLQLESESMRRVAAASTTTTTSLTGGAPLATAQPAQGLIAGTIRCVRDVYRREGIVGFYRGMSASYAGTLETIIQFVIYERLKEFAAKVRADSADVLMTTPQLSTTTDSGWESDDSAFGQRESTQSLPKHRLSAQPSAAVPSNAETSKSLRDFVEYTTIAGVAKLVASISTYPHEVIRTRLREKPVGNVAKYRGFFHCLGKIAIDEGWRALYSGMPAHLARVVPNTAIMFLTYEIVVHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIK2</accession>
    <name>A0A0D2WIK2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIK2"/>
    <dbReference type="InParanoid" id="A0A0D2WIK2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="470" mass="50174" checksum="B51D722E34718E9C" modified="2015-04-29" version="1">MKPNDCNTLEQSLAFWRFLTSCTRAFHALHAEICVRRSSRGSSAANSPPGTVPMLETLAARKVAQMLPTLSVTDLQDLYWAPILIREIVYQSAIRAGTLTDDVLVVLLHLDDGYRSVDVSNNSSVTNAGLLSVLPPAADPDAESLADLETWEDLFDDVGGLDQHEQCRSIVLPVTPAASPVGSISAAPIAIPLQQPASTSCQQSHGQESPSGSLPSRPGSSWNRDACSEAGRHVSTPTAIRRVPPRRSRDPLQQLQFDMDDVLEDVSSAPELPISNREAKPAAGSSTAKSSDCADAGLGQRPRGRSQSQPALTLGRRQVSTSAPSSATALSTSPPMPRGIGGFSLRACTVHIVTLDMSFSLGIIGGGAFVRQLAERLPALADLRIAGCFDEETGPETLLTIFGALTNLVYLDASKNYWLSGAELDYLVRKTPPPQSLLPRLSAFVLAGCPMLRHEHLHALAVARPSLQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIQ7</accession>
    <name>A0A0D2WIQ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIQ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WIQ7"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIQ7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="392" mass="41324" checksum="88BC18581BE1BE02" modified="2015-04-29" version="1">MQDTEGICYAVSEGNLSLVRKLLAEGANVNCIVAGQPSALPPPLYLASARGHLELVVELIRAGANLDGENTGYASPLRIAAERGHAAVIHELIRAGAQVNHLSGTREATPRTALMSASEQGQIDAVNALLHAGADVSTTMSNGLNALDVAVEKNKVEIAAILLRAGSHINWRAIYNVVRSNDLAMLQELLRHGADIKGKDSLLDAVRPAAGNGIDIKYAPMVLALVQAGAQDADGLSGYAWARHGNLEIVSRLVLGGTNSNRFLMAYLGAASTGQLAVLRWLFDVSKSPALLSSALSHACHANQAEAVRAILMAAAASQMKLEVNEPLLVACDRNFVHVSEALLDADASPNFVDKLGRPLLHIAVTQNHVALTRLLLAAGANPDAIMRFQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIU2</accession>
    <name>A0A0D2WIU2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GtrA/DPMS transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349779.1">
        <property type="nucleotide sequence ID" value="XM_004349729.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIU2"/>
    <dbReference type="eggNOG" id="ENOG502SDKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIU2"/>
    <dbReference type="OMA" id="INWLAVE"/>
    <dbReference type="OrthoDB" id="199351at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA_DPMS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA_DPMS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA/DPMS transmembrane" evidence="6">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="15711" checksum="DCC75350C1798F62" modified="2015-04-29" version="1">MPKHSPATEAIWFQISGAIGTLLFYAFYEGLYRIADFEWQKAAVCNAIAYAVSIIWQHALHRTLVFGATPGVSYWRSLGSTYLCYGLSIALLGPISVALDFVTGNHQVTWVLGLVITGAINYFTVKQAFAPPKGAQLDELHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ11</accession>
    <name>A0A0D2WJ11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_000694</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365565.1">
        <property type="nucleotide sequence ID" value="XM_004365508.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ11"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ11"/>
    <dbReference type="eggNOG" id="KOG0135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ11"/>
    <dbReference type="OMA" id="WKLPGCF"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="170"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="315"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="541"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="705" mass="78847" checksum="552708DD3E81786F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJW9</accession>
    <name>A0A0D2WJW9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJW9"/>
    <dbReference type="InParanoid" id="A0A0D2WJW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="15911" checksum="9F2AD0FB4AA1EA84" modified="2015-04-29" version="1">MRIRRPQSIGSLAQRTDKIAKTHGTALEHGVQRRRAVCDHAAATLTRALEWSTMEALPCRRRRGVALGCGRAENGGKSRKSHERTANVDAVTSLTRSLSSRLSRLACVCVLRWLVCRSESSKPLKRTRKTGEKMNGKEENETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL49</accession>
    <name>A0A0D2WL49_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349120.1">
        <property type="nucleotide sequence ID" value="XM_004349070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL49"/>
    <dbReference type="STRING" id="595528.A0A0D2WL49"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL49"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="269"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="390" mass="42198" checksum="6F9A3FB42E3F6D02" modified="2015-04-29" version="1">MLPSRAIARFGGLLVRFDSAAATRRLSGMPPRPTATAPLMSTSEPFGSGVQSSRLPQRSHNDEQQQQRENKQQRNHKAASASATIGATAAALLAAAGAVAATASVLAKNRTVVHAAAATTAGAPPPARAEADASEQPKSDRQRHSQSPSPHQDKHAVSQEQHAQQQHHHHHHEAESKASSNSAEHPRHPHAIDLQQQLSGLNTLEQVRANPKFRFLNPFKTVDVSNTLTFEALYGPGKFENVEMYHNPTDLQFVGMFKLGNRICGHPDTIHGGAIGVAFDETLGWLFMLTAGVGYTANLNINYRKPLPALHTIVVKAHVDRVEGRKVFLHATLEDLHGLVYADAAALFVVPRNKQALLDRYGKLESPSYAQVVAKEPPTSFAPTQTPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLT3</accession>
    <name>A0A0D2WLT3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348925.1">
        <property type="nucleotide sequence ID" value="XM_004348875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLT3"/>
    <dbReference type="STRING" id="595528.A0A0D2WLT3"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLT3"/>
    <dbReference type="OMA" id="KNYEARC"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF61">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE-INTERACTING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="349"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="417" mass="47919" checksum="FFD619EDA035AA99" modified="2015-04-29" version="1">MSSNLFESAFWDTDIISTAGFDVLCKRLREGKGSVHNYAEFARQRAAIEEVYAKSLIKLARSMVSKNELGTLRRSWDVLRTETENAGYLHIKAAAQISNEIEKTTRDFKLSQKTARKKTEELVKNRHATKLSAFEHMQKSRKTYETKCREFDTAEKEFKTAPTSKDVDKLKAKMKRSQEASEAADVAYQLSLTQLEESRRQWEGEMETCCKHFYDLEKERILYLRQSMWAFANIMSSLAVQDDELQEKVRCSLEECDWGKDLEEFVRTRRVGSQRPAMIGYINFYTGPRALPAAAVHSANLNSGLSPDYLPTLQRSTKPTSTLLQQLHQQAQPHQQAQPPPPPQSRMVSLDFIVVARYTYQAQGDQELSFNEGDFIRVLDNDANDWRRGELLTQDLTSFDPPIKGMFPAQYTTRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM32</accession>
    <name>A0A0D2WM32_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363741.1">
        <property type="nucleotide sequence ID" value="XM_004363684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM32"/>
    <dbReference type="STRING" id="595528.A0A0D2WM32"/>
    <dbReference type="InParanoid" id="A0A0D2WM32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="3">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="874" mass="93558" checksum="09C297BB85CE8626" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN43</accession>
    <name>A0A0D2WN43_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Roadblock domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN43"/>
    <dbReference type="STRING" id="595528.A0A0D2WN43"/>
    <dbReference type="eggNOG" id="KOG4107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN43"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN43"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="137" mass="14380" checksum="E9BF046AE95D0E83" modified="2015-04-29" version="1">MQRCLMRDDGLSVGWSGGWAGRAGLLTQNGTLIALTGDNDQSARVTGAIAANVWHAFEREGKAAFDTTAMNFLLLGCESGRVGVTRVAGLLLCLYAKPSVEYGLLKSKALALAKHLEEPLSSVVIGGLAVGTNLDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN84</accession>
    <name>A0A0D2WN84_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363730.1">
        <property type="nucleotide sequence ID" value="XM_004363673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN84"/>
    <dbReference type="FunCoup" id="A0A0D2WN84">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WN84"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN84"/>
    <dbReference type="OMA" id="YICGENT"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN84"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000223">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="111"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="24517" checksum="3895055725E9135B" modified="2015-04-29" version="1">MAQVEIVTPGTRLGTTQDFLPGAGTYVRPDDLNAIGGRGSTIVAALAGFRIVQQPTTTAHAAASASTAAASHAMEIDDDNDAAGAASARQVLPSIHVVRDLHDANPIPAIGNVVTATVTSITSRFAKVNILCVGSSPLREPFHGMIRIQDVRETEKDKVEMYKSFRPGDIVRAEVISLGDSRSYFLATSKNDLGVVFAESAAGASMLPVSWCEMQCPKTKAKEFRKVAKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNI7</accession>
    <name>A0A0D2WNI7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNI7"/>
    <dbReference type="FunCoup" id="A0A0D2WNI7">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNI7"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNI7"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNI7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266472" description="U3 small nucleolar ribonucleoprotein protein IMP3" evidence="10">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="204" mass="23834" checksum="E41F03CE9CF31416" modified="2015-04-29" version="1">MQSVLLFDFFHPFAFLSLCFATMVRAFKHHEAKLLKKVDFLQWKSENNLREVKVLRKYHIQRREDYTKYNKLCGIIRSLASKISLLDDRDPHKAHTSSALLDKLYRMGLIVTAKGFHQCEAVTASAFCRRRLPVVMVRLKMAENVREAVQLVEQGHVRVGPDAVNDPAFLVTRPMEDFVTWVDTSKIRRHVLKYNDKLDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNR5</accession>
    <name>A0A0D2WNR5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363479.1">
        <property type="nucleotide sequence ID" value="XM_004363422.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNR5"/>
    <dbReference type="STRING" id="595528.A0A0D2WNR5"/>
    <dbReference type="eggNOG" id="KOG3500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNR5"/>
    <dbReference type="OMA" id="CCIMLTA"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNR5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="74" mass="8127" checksum="A1C27CEA6ADF2C4E" modified="2015-04-29" version="1">MVAGGIVILIFTIVFLVLGGAGFFFAPKGPNRGLVQTMSILTAFCMWIFWLCTFMSQMNPLIAPIIKTEDIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNZ4</accession>
    <name>A0A0D2WNZ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_003258</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WNZ4">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNZ4"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNZ4"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="266"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="480"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="602"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE92253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1377" mass="154254" checksum="17D6F8330669B963" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP71</accession>
    <name>A0A0D2WP71_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP71"/>
    <dbReference type="FunCoup" id="A0A0D2WP71">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WP71"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP71"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP71"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="372"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="720" mass="78833" checksum="F471204948C0E715" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPC7</accession>
    <name>A0A0D2WPC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347835.1">
        <property type="nucleotide sequence ID" value="XM_004347785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPC7"/>
    <dbReference type="STRING" id="595528.A0A0D2WPC7"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPC7"/>
    <dbReference type="OMA" id="WASHAGD"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="184"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="463" mass="50685" checksum="DE513F7FA2DF9F3C" modified="2015-04-29" version="1">MTPTVQPRRTASVWIRRALLAAIIAGLVITWVALAELLQVVQHDKNYNKPFFLTYVVHGSYIIFWPVYWAVLRTHAWRAATTTTSRRPPRKLTRSSLLHSNHEDGTTSTNGAGSTPAAWSHTNAAINANLDDSDAYNQPSKAASLIHKQHESPYLQDEETPLIAHSTLPSTSSDTSGSGSSLFACFRNLRSPLPFTGRRYAWATFIMQLVFFFVSATWYYSLDHTSVAANTGIYNSSCIVVFILSALFLKEKVTKFKVAAVALSVGGVLMISFAPSSSSSDSSTVNPSALGYIMVVVSTVLYAAYEVLYRMICVDVTITDRVLYVASSFKVLGYIGFWNLLLVWPVLILCHYTGWELFELPSSEALPYLVGAALIDSVFQILLYLGILISSPLFIAVGCMLSIPGSIVADYIFHGTVLPALALGGIAVLSVGFALLNYDEYREQRHNQPSSSATSGCRSSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPN9</accession>
    <name>A0A0D2WPN9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363305.1">
        <property type="nucleotide sequence ID" value="XM_004363248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPN9"/>
    <dbReference type="eggNOG" id="ENOG502TDCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPN9"/>
    <dbReference type="OMA" id="CLTLRYN"/>
    <dbReference type="OrthoDB" id="10265086at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03786">
        <property type="entry name" value="GTB_UDP-GlcNAc_2-Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174:SF2">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-N-acetylglucosamine 2-epimerase" evidence="4">
        <location>
            <begin position="122"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="504" mass="54854" checksum="D3CEF188FC1C5577" modified="2015-04-29" version="1">MPSFRLPPFVRKPTVLALVFMLELVVALALLSSSTGLNGWKLGNPAPDNVDVQLSEQQPGASGDAVSPLPAALAAQLHQLAQHRQNQARRRPLALVFVGTRPEVIKMAPLVHEMQENSVNSHVFDTIVVSTGQHREMLAQTLRGFDLKIDLGLSVMQHNQNLGALFAAVVAQSTAVIASLRPEVVLVQGDTSTALACATAAYYERVPVAHVEAGLRSFDFNHPFPEEMNRRAIDSFATFHFAPTEYAAEAIRRENTCARNIVVTGNTGVDAVLARLNADPPAAARRLIAQLQTCTGGACDVNDAPPVIILVTSHRRENLGEPLESICRAVKRIVEDNPVVRVVFPVHLNPNVQKVVFAHLKNVDRITLTDPLDYDVLTYLLQEVTIVLSDSGGLQEEAVSIGKPVVLLRQTTERPEGVYAGTVRLAGTNEDRVVSDTQNVIDNLVEYHQRIKGQNVFGDGAASGRIANVLRQYLAADSAQRRKYLAPCTQEKQAELANVVYGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPT8</accession>
    <name>A0A0D2WPT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPT8"/>
    <dbReference type="InParanoid" id="A0A0D2WPT8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="116592" checksum="2B0703136664999A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ43</accession>
    <name>A0A0D2WQ43_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ43"/>
    <dbReference type="FunCoup" id="A0A0D2WQ43">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQ43"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ43"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ43"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="36370" checksum="EEF78FA06D4AFCE3" modified="2015-04-29" version="1">MANRTVRDAVSVHGTNPQYLIEKILRERIVEDAYWKEHCFALTAESVIDKAVELAYVGGTFGQHVKPSPFLCLTLKLLQLQPSHDIIMTYIENTDFKYLRALGAFYLRLTAQSLEIYEVLEPLYTDFRKLRTRNKEGEYGLTHMDEFIDRMLRDDRVCDVALPRLMQRHVLEVSGQLEPRVSVLEEDMEDNEEAAGDDSADDGEAEKPDWVLQVPLHRDKIAVAAVVAVQILDTKADMRDLDLAALLAIQRHGIAVEARVEAEAEALLHVTLPAAAAAAVPDDPSKAIDRATTVAAAAAAAVHRTTIPIVGAAQVLVGAELSGPSPWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQA9</accession>
    <name>A0A0D2WQA9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQA9"/>
    <dbReference type="STRING" id="595528.A0A0D2WQA9"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQA9"/>
    <dbReference type="OrthoDB" id="4571707at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQA9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF84">
        <property type="entry name" value="REPEAT TRANSMEMBRANE PROTEIN KINASE, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="372"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="640" mass="70175" checksum="2B7A84C694DBE640" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQE8</accession>
    <name>A0A0D2WQE8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347360.2">
        <property type="nucleotide sequence ID" value="XM_004347310.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQE8"/>
    <dbReference type="eggNOG" id="KOG1949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQE8"/>
    <dbReference type="OrthoDB" id="10062843at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQE8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1390" mass="149548" checksum="6FDC1B70B7535B9F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQL5</accession>
    <name>A0A0D2WQL5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQL5"/>
    <dbReference type="FunCoup" id="A0A0D2WQL5">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQL5"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQL5"/>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQL5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="366"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="902"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122956" checksum="0275A5AA5C442DB9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRT1</accession>
    <name>A0A0D2WRT1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346992.1">
        <property type="nucleotide sequence ID" value="XM_004346942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRT1"/>
    <dbReference type="eggNOG" id="ENOG502SG7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRT1"/>
    <dbReference type="OMA" id="ANSDGYM"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266533" evidence="1">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="281" mass="30468" checksum="102C5425AABC2882" modified="2015-04-29" version="1">MQPAARLALLVIAAIAVASCSSSSSAAAAAASSWSMKQEHIFLESFFASSPQGVAMLFANSSVPEQIVFSGKTILRRCSYVGKTMTFASILENPNALANVSALGYNHIGDIDIYNGVLYAPIEEDSYTRPAIVTYDPMTLEYTGLVQTTQKHMPWVAVSSLYKFLFSSEFDNVTSLYVYQVENLKMGLFTILDLHLPVGLEQGLMAVQGGVVSGTNLYLSSSAPGDPVYVVDYRTGIVQLEFNLPSTQETEGIAIANSDGYMYVLVQNNFDVVAYQYSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRU4</accession>
    <name>A0A0D2WRU4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_005327</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347012.1">
        <property type="nucleotide sequence ID" value="XM_004346962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRU4"/>
    <dbReference type="FunCoup" id="A0A0D2WRU4">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRU4"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRU4"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRU4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="19">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE94735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="181" mass="19008" checksum="8136A173BC05F6C0" modified="2015-04-29" version="1">MLRSAFRSSFAALSKHAGPVGSAPASAPAAATASNPDLLDRLQQAMKFIADPANPGFDSNLHGLEITHAEEGRVVCLFKLTEHHTNRMGNLHGGLSATIVDIVTTLACVSKTNHPGVSTDLNVTYLNPATVGDTIRIEASVIKAGGRLAFTAADILRNHDNVIVAHGRHTKYMAGGAHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT79</accession>
    <name>A0A0D2WT79_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT79"/>
    <dbReference type="InParanoid" id="A0A0D2WT79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="151" mass="15680" checksum="507E30D51B43F43F" modified="2015-04-29" version="1">MAARLVEFQASPPAARAAAAPASDSADDDSDSDEATRVSLMTPPVASRLLVGRWTSDRAIIIIASAALCCPSSTSALLQPPMRRPAVCRAADGANASRLHPPAAATTPARSIRPSTGLCVAMLNSDDGKRIERLRLVNGTSTSMEALLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTP8</accession>
    <name>A0A0D2WTP8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Presequence translocated-associated motor subunit PAM17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_005566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346239.2">
        <property type="nucleotide sequence ID" value="XM_004346189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTP8"/>
    <dbReference type="FunCoup" id="A0A0D2WTP8">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTP8"/>
    <dbReference type="InParanoid" id="A0A0D2WTP8"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="261" mass="27937" checksum="B6C105FF210C5498" modified="2015-04-29" version="1">MLLSSCRPRFGFFAAAHALGSVAARPAFSIPTLTLARSLASSSSTASPTDDAAKIPPTTTTTTTTTTTTTTTTAAAEPATATAAATAAATPKPPMMPFNEYCKAKTVHNMASNIAGVPVAIGSILLNSWVFVMVFPEVYDGSVPQDQLPQFFGLDLMVIAGMTGMASAVLGFAGGKWLYSQAYALLAPARARQMDARHADFVDRITTRRHATTSMSDDYYGDKIKSLSDYRKWLRVQHKRGKEPANDALRDPFADFGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUH0</accession>
    <name>A0A0D2WUH0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345613.1">
        <property type="nucleotide sequence ID" value="XM_004345563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUH0"/>
    <dbReference type="InParanoid" id="A0A0D2WUH0"/>
    <dbReference type="OMA" id="WRALELY"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="622" mass="68918" checksum="5916D355297F24B2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUT8</accession>
    <name>A0A0D2WUT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344419.1">
        <property type="nucleotide sequence ID" value="XM_004344369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUT8"/>
    <dbReference type="STRING" id="595528.A0A0D2WUT8"/>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUT8"/>
    <dbReference type="OMA" id="KTWQREL"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17002">
        <property type="entry name" value="CID_RPRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="375" mass="40799" checksum="8D2CEE1518CF3A68" modified="2015-04-29" version="1">MAFSTGNLETKLNALNETQAAIQSVSLWIMHHRRHASESVDTWFEKLCAVDASKKLAYMFVANDVLQNARKHGTEFTEAFRPVLIDAFAHVAGECEPPVVKSLNRVLTVWQDRSLYPADFVAQLKSALNSSSSESSSATASTSAAASQVEKRIPQPVDPDALALQLRQIQDAVVSDTLIQQRVTVLPVSSLKQRVATEVKDHQSGTYFQDQVSQGQRATLQLMERLEAQTKQRKRVIEMLQDALALQNQAVAKLAETAKECQEKMDTLNAAETELNSIMKSLPSIGYDTSSYSRLPSTSELFSRGGSGASSSRSHMPYATGGYASGYQQPSSSSASAPAWRTAPAVQPPTSSSEAPVDPRKRTATAAGFEQMGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV08</accession>
    <name>A0A0D2WV08_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345064.1">
        <property type="nucleotide sequence ID" value="XM_004345014.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV08"/>
    <dbReference type="STRING" id="595528.A0A0D2WV08"/>
    <dbReference type="InParanoid" id="A0A0D2WV08"/>
    <dbReference type="OMA" id="NTMIELA"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV08"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13048" checksum="5B12A396B9138D60" modified="2015-04-29" version="1">MAQDEAPSEYPPTPRVNNSMLAANVDRFVRLVGTVMKINQSTVTIRTSDKGETIVHTNSNAVYAEGDVIEYIGSVQPDLSLVAETFAPFPKSFNMDNYNTMIELARKQYHLFSAVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW40</accession>
    <name>A0A0D2WW40_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343468.2">
        <property type="nucleotide sequence ID" value="XM_004343418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW40"/>
    <dbReference type="STRING" id="595528.A0A0D2WW40"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW40"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW40"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF50">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="360"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="573"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="767"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="900" mass="95905" checksum="F55D7F1DB6DB7101" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWM9</accession>
    <name>A0A0D2WWM9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAOG_007198</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343922.1">
        <property type="nucleotide sequence ID" value="XM_004343872.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWM9"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWM9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWM9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="82"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="344"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="1125"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="1232"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="23">
        <location>
            <begin position="1381"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="611"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="958"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1195"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1268"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="890"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="620"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1020"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJE96958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1704" mass="185310" checksum="743B38B81BD2F46C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWX1</accession>
    <name>A0A0D2WWX1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343464.2">
        <property type="nucleotide sequence ID" value="XM_004343414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWX1"/>
    <dbReference type="STRING" id="595528.A0A0D2WWX1"/>
    <dbReference type="InParanoid" id="A0A0D2WWX1"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="8">
        <location>
            <begin position="239"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="428" mass="46969" checksum="2C3ACE642CE996E3" modified="2015-04-29" version="1">MSTTSHPAADVDATRQQLEFYYSDANLARNGFLMQRIRESPDGYVPVATIASFNKLVALGADESLIFAAAQASPALEVDANKTAVRRRTPMPAAYNADDRTIYVEGFPKTTTIDHLRAFFEPYSHVLAVRLPKFHGGDPKGFAFVELALLEDVDRVLQELSDRPFSVPDVPSDPSLAEPLRIMTLAEWSDFKDSYKQIKKLVAKETKKQRAKQTQQALVLPPGRAAGQVKSVQEPYRTPFVPGVIIQLTELSPDSSKAGIAKELAHHGQVKFVEYTAGQAVASVRCVDASSAQAILRAAHSQAFPFKVSELRGGAEKKFWQTLWSAQDAKHSIKPAVKNEPFKSEVEPERPASHTAASKRSLSESLESDAIVAAQPSSSTTTEAPAAKKRRTTRRKKKSHGAATGAAARVHTFFEIEEEERDDQGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXL8</accession>
    <name>A0A0D2WXL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tropomodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342642.2">
        <property type="nucleotide sequence ID" value="XM_004342593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXL8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXL8"/>
    <dbReference type="eggNOG" id="KOG3735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXL8"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40526" checksum="8A42BD31111148FD" modified="2015-04-29" version="1">MSDEDFEGLTEEELNQLADELKDESAPSHPRGASSSSSSSAPRRPTAAASSSSSSSSSSSSSSSSGVDSSSYNPDQLKKFMLSQAESTPDVKEKIPYRTPTKSATSSTTSSPAFSKQPPVATESAAASKARAAIDADDELLVALTGQSEADLLKMAEELNEEDRERGRVVRPIVAAGPAGSRSSGNSNSNSGIGMPSVVVATQVDRPRDDGVNSVDLDQTLKRVESNDSTLTAINLNNHPDLTVERAAAFARALGGNTHIIDVKMSNAHVSDAVAHDLIDSLKTNSTIQVLHLETNQISGKVIKQMIAAIVDNKTLIELKLTNQTNSIGDSYEMEIARLIDGNDTIRKLSLSCRSVAARNSIEKVASRNSEAARKRRVAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXQ2</accession>
    <name>A0A0D2WXQ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tenascin-X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXQ2"/>
    <dbReference type="InParanoid" id="A0A0D2WXQ2"/>
    <dbReference type="OrthoDB" id="543142at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="585" mass="63226" checksum="E16357FD5E35D974" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYT9</accession>
    <name>A0A0D2WYT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342486.1">
        <property type="nucleotide sequence ID" value="XM_004342437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYT9"/>
    <dbReference type="FunCoup" id="A0A0D2WYT9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WYT9"/>
    <dbReference type="eggNOG" id="KOG0464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYT9"/>
    <dbReference type="OMA" id="YAGNIMG"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254769" evidence="7">
        <location>
            <begin position="23"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="128"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="949" mass="101393" checksum="57920DAE7686B844" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0W3</accession>
    <name>A0A0D2X0W3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0W3"/>
    <dbReference type="InParanoid" id="A0A0D2X0W3"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0W3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="953" mass="103951" checksum="1F3F92B35DE226D8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X101</accession>
    <name>A0A0D2X101_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349867.1">
        <property type="nucleotide sequence ID" value="XM_004349817.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X101"/>
    <dbReference type="InParanoid" id="A0A0D2X101"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270319" evidence="3">
        <location>
            <begin position="21"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="789" mass="82782" checksum="CE422BF5DC0DDB05" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1D5</accession>
    <name>A0A0D2X1D5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364771.1">
        <property type="nucleotide sequence ID" value="XM_004364714.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1D5"/>
    <dbReference type="InParanoid" id="A0A0D2X1D5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="385" mass="41384" checksum="D828EA2A17198F7B" modified="2015-04-29" version="1">MSVFVVPPAPARIGNETKQQLREQLFGELALHDLHHEQELMKNMHAQRVQLSEQQCKQPSIAFLDMFGLPQPAVNLANFKSPFIVPPSIVPPVSYFTTNSNYNMGLYPAFNPSLSFAAAAAAAAFAPPQLTLADVMAGPAVKRERLDSAASIMSALSASSDASAASFLGNSDNFALPEPTTMETLLANLQHSSTLYPNLCNAFPVVLRPTSSLSSCTESRDVSSSASTLSSAGASPAPVVVSDSSRKRRASFDDEDQLFDSDGFNAGETFTLSSLIASAATSAGPVTPERLAHCLHDPLPPMPVPASQSVGNRVSRIDPNVDNVTAARRKKEREAKAASRQKQRDLMNDLERTNALLDQEHAELKQRVLSLQSQLTMLRGLVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1D9</accession>
    <name>A0A0D2X1D9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L23a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364786.1">
        <property type="nucleotide sequence ID" value="XM_004364729.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1D9"/>
    <dbReference type="FunCoup" id="A0A0D2X1D9">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1D9"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1D9"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1D9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="157" mass="17189" checksum="F355E0B8F0AC8ACD" modified="2015-04-29" version="1">MAKPTATATSKPKGQTPAADKALKARKANEKGTNGVAKRKIRTTSTFHRPKTLALPRAPKYPRRSAQRTNALDAYAIIKHPLTSESAMKLIEDTNTLVFITDVRANKAQIKDAVHSLYDIKAARINTLVRPDGFKKAYVKLAADQEALEIANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1P5</accession>
    <name>A0A0D2X1P5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1P5"/>
    <dbReference type="InParanoid" id="A0A0D2X1P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="232" mass="24360" checksum="5729937DE4F08E4B" modified="2015-04-29" version="1">MSNAEARKHKRIAKQHVTRRKPLPTTTTPASLPASSEDFPAASPVHSSPSSPSAFAPPAASAPPAPRPASEAPLLRTVLINNSLKLACRQRHELDRREYDQRTLFLQQLSQQRAALLNPGLNTPASNNTNQIICSPMMLLATPPPLPSSDGDCLSNSSSSSSSSSSNNSDSSDNEFDEVASTSDQGNSCPQSPSPLTAMVEEGKTTLASQCLLPQPSLLSSSLTVSGFGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1U1</accession>
    <name>A0A0D2X1U1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349285.1">
        <property type="nucleotide sequence ID" value="XM_004349235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1U1"/>
    <dbReference type="STRING" id="595528.A0A0D2X1U1"/>
    <dbReference type="InParanoid" id="A0A0D2X1U1"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1U1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10801" checksum="F8BB12373CD35C2E" modified="2015-04-29" version="1">MTESDPDRPHGGVGDSPPAAADRKKCYAARDAYYECAAKNIGNEASACSELRRALEGSCLPSWVRYFDRKVLYEDYKRRLAEEERARNQEQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q3</accession>
    <name>A0A0D2X2Q3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pirin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q3"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Q3"/>
    <dbReference type="InParanoid" id="A0A0D2X2Q3"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Q3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000055">
        <property type="entry name" value="pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="33388" checksum="863CB832BBDE4BF9" modified="2015-04-29" version="1">MSAALSTPIKFLSRRVVKSILGVEQGEGVGARVRRSIGRPELGRLDPFLMLDYFTGVPPAGFPDHPHRGFETVSYLLEGKFAHEDFAGHKGVLNAGDLQWMTAGRGIVHSEVPLTKSVGLQLWVNLARKDKMIEPNYQELLKKDIPVATKDGVTVTVIAGSSMDIDSAVYTRTPTMYLDFKLDPNSSFNQAIPKGWNGFAFTISGKAYFGPADSVSVAFSFALNLPFGLISPSLSQEPAHFVLIAGKPLNEPIVQHGPFVMNTREEIMQTIRDYQERKNGFERAAGWYSEAGRTQYGLGEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X360</accession>
    <name>A0A0D2X360_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X360"/>
    <dbReference type="STRING" id="595528.A0A0D2X360"/>
    <dbReference type="eggNOG" id="KOG4646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X360"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="347" mass="37134" checksum="1B0F0D9FA325FB48" modified="2015-04-29" version="1">MPSLMNKFGGSLRLTPPTTNNSTSSSDSSEADASTQDTAQQRSNGTVAGAGAGAGAGAGTNSTATTSNLTSDEPETKPKLNKLQPKQSRRQLAMQLAVMSGMLPPDEEALEAMDALDAMDLEDEADQDEDDEGDEDNDEDVDVNDDVDDDDDDDDQYEDVEDEDSLEVAELNRQLDALGAVLDVFENHSKNLEARVEAYRAQLLAEHKQRDADAKQESGSGASGSSSGSSTSAANVMYSTPEQLRRQTPASALPRFEYLQALVGELRAASTTPEARLQVLANLANFAYDPINYDHLVRLAVPDALIDLVQSPPALRPGAITAVEQLQFQQFALGGLCNLCLGNPEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C4</accession>
    <name>A0A0D2X3C4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347512.2">
        <property type="nucleotide sequence ID" value="XM_004347462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C4"/>
    <dbReference type="STRING" id="595528.A0A0D2X3C4"/>
    <dbReference type="eggNOG" id="KOG0690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3C4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3C4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01241">
        <property type="entry name" value="PH_PKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000033">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000027">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000362">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039026">
        <property type="entry name" value="PH_PKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="145"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="403"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="473" mass="54513" checksum="BCADCDA989DB35A4" modified="2015-04-29" version="1">MATTTPTANTTTSTAPFTIVKEGLLYKRGEFIKTWRPRYFQLCSDGSFRGFKESKPVADEEPLNLFHVSNCRIKLADKIKKTAFTITFFQLTSYIERIFYTETKEDREDWIKHIRSIADRLQDEQAKSPEPSEASADKKLNLEDFEILKVLGRGTFGKVVLARKKDTREIMAIKILKKEVIMAKDEVAHTMTENRVLQKVRHPFLTELKYSFQTEDRLCFVMEYVNGGELFFHLSRERKFPEERAKFYAAEILLAITHLHDLDIVYRDLKLENLLIDKEGHIKITDFGLCKEDVGFGNTTKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVLYEMLCGHLPFYNRDHEVLFELILKEEIKFPSSLSPAAASLLAQLLQKDPKNRLGNGTRDGREIMEHPFFANINFDDMYNRRVPPPFLPKVASDIDTSNFDADFTSESTQLTPPEESALRKTADAEFQNFTFVADSTLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3F3</accession>
    <name>A0A0D2X3F3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase 1</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_004887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347638.2">
        <property type="nucleotide sequence ID" value="XM_004347588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3F3"/>
    <dbReference type="STRING" id="595528.A0A0D2X3F3"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3F3"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3F3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="318"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="721" mass="79090" checksum="7E81A04996521D8B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3G9</accession>
    <name>A0A0D2X3G9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3G9"/>
    <dbReference type="InParanoid" id="A0A0D2X3G9"/>
    <dbReference type="OrthoDB" id="427001at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3G9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17982" checksum="A307E8104D4BD457" modified="2015-04-29" version="1">MLTYANMNERQRELYDEVTNEPNYVDLTDRELGDAEALAIAEALKVKTTVTGIHLDTNRIGEVGARAIAETLKANTLTFLNLCWNHIGDAGAQAIAELLTANTTVTYLDLSSNQIGDAGAQAIAEALKVNTTLTELFLWYNEISDAAVPSIVEVLKVNKTLKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3H1</accession>
    <name>A0A0D2X3H1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transducin family protein/WD-40 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346650.1">
        <property type="nucleotide sequence ID" value="XM_004346600.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3H1"/>
    <dbReference type="FunCoup" id="A0A0D2X3H1">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3H1"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3H1"/>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="415" mass="45596" checksum="EFBA1866924190CC" modified="2015-04-29" version="1">MADDGDVRAPSDLVLEDQVFELAFHPALDVVAVGLINGRIGIYQYSLDGNQALLDLTHHRKACRALAFSADGNVLYTGSGDKSIQAVDMNTGVILAAIDKAHEEKINTLIAFEECMLATGDDGGAVKIWDTRQAKSIFQFKENEDFISELSYVPGKRCILAPSGDGTLSVFSLRKKGLLARSENQEDELLSAVTLKNNRKVVCGSQGGILDIFTWDEFADISDRFPGHPDSIDSIVKITEDIVATASSDGLIRVVNIQPNKLLGVLGEHPDFPVERIRKSRDSKLIGSCSHDQRVKFWNIEDFYAEEEEGELPDLAEDAMASGAGVDAMDNDDDENADEDEWADEDDDGDDDDMDSDDDDDDDDDDDDAMDMDTGASSSHGRLQKSRAQQKQNNGKKKKQQQQASRDAQRFFSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3M4</accession>
    <name>A0A0D2X3M4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346877.2">
        <property type="nucleotide sequence ID" value="XM_004346827.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3M4"/>
    <dbReference type="InParanoid" id="A0A0D2X3M4"/>
    <dbReference type="OrthoDB" id="5960226at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="217" mass="23254" checksum="5F9F232C21A67A33" modified="2015-04-29" version="1">MVQSFIVLKCYADGCATHQVQQVKKSTKWTCVVTGHEHAQGDQQAVPAAEPDDTCELYSEPHDASSYLTQARTCSSSSSSSSMVVVVAMAIRWRAKTFDDPSQSYNLSSCRARGQPASIARHQAAGSHSFGQAATDIGSQSRRTGVSTAQVMTPPASNSGSTAAAASIVTRLLQDARRDLSKLSEPAPPAQRTSKWATFMPARRNNQDADDDDEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3W3</accession>
    <name>A0A0D2X3W3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346212.1">
        <property type="nucleotide sequence ID" value="XM_004346162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3W3"/>
    <dbReference type="InParanoid" id="A0A0D2X3W3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="338" mass="35269" checksum="3A1B18664CF29E07" modified="2015-04-29" version="1">MLRLKALLQRILPSAVPSSSASALRSSPTLPAPPTYVRTAPASSYPAAAAAQPHKHPRVHFPSLLAAALEPIPHRVRPVVVMTSRTASWPLHQRFLHSLPASALAAEPATTSSSSSLPKDAILPQAISQTSDKGASGTCAAAALDHAQASSSSTSNAAARSSSSSSASSDNATLPVDMHVTAAPTSSEEVDERTVVATVAMRLEEGIDGEASFTRDSHGHLTMRPSDPLAPWEREKLVGKSTTTSPDEAIAIHEAHEHETFLSESEPEPATASSGSSVQHGLHPLEGFQANRAPSVEETESQTLANEGNRAMSAEEVLEQDGAPTGVRSDHKVPTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X426</accession>
    <name>A0A0D2X426_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X426"/>
    <dbReference type="STRING" id="595528.A0A0D2X426"/>
    <dbReference type="eggNOG" id="KOG3729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X426"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X426"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="499"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1202" mass="131646" checksum="AD0532CA794508E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X442</accession>
    <name>A0A0D2X442_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cdc6B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X442"/>
    <dbReference type="FunCoup" id="A0A0D2X442">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X442"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X442"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X442"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="325"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="5">
        <location>
            <begin position="583"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="689" mass="76326" checksum="45A09BAEFC05E85F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5A2</accession>
    <name>A0A0D2X5A2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5A2"/>
    <dbReference type="STRING" id="595528.A0A0D2X5A2"/>
    <dbReference type="InParanoid" id="A0A0D2X5A2"/>
    <dbReference type="OrthoDB" id="10251426at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5A2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037351">
        <property type="entry name" value="Murr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="114" mass="12530" checksum="16B6C5118AD3B140" modified="2015-04-29" version="1">MAQVWNNRLASLSWRIDVKTKSRHVENINEATSIVELKIAQLDKSTETVRFELNSDRMQFLVGQIEAIEKQLSAQASVPVVKPLIKAKPTGPSASKPTVTSKPKPALKPTPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U067</accession>
    <name>A0A0D2U067_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365085.1">
        <property type="nucleotide sequence ID" value="XM_004365028.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U067"/>
    <dbReference type="eggNOG" id="KOG2998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U067"/>
    <dbReference type="OMA" id="WMKWILR"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U067"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="145"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="332" mass="37608" checksum="C3B9708A8B2A7F77" modified="2015-04-29" version="1">MTHPASSSVASNAARGRRLAARPSLFHRILKWVLHVLTRACELQRLLSALPVQAQPPSDVVARVELSLMWSRVLPDLSLPVSQHQSFDVPRAVHYVKAQKHIQEPADSPFTAQLRRCLEMISDLGTLFERVTELQDTPYDSSQESNEAQLVELWELMMPEQQLSARVSNDWKTLGFQGRDPATDFRGMGMLGLKQLLFFAQQHNTQARGALTVSCHPERGFSYAIVGINLSSMAVEFLDNPKLHELLYHLSNQPECSKDSLVNFNDFYCFLFCEFSRLWRQVNPENMLAFNQIRDSLKATVTRTLEHNLEAVSAAIVAMRVLNHDANSSIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U164</accession>
    <name>A0A0D2U164_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytochrome chromophore attachment site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365399.2">
        <property type="nucleotide sequence ID" value="XM_004365342.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U164"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U164"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF42">
        <property type="entry name" value="TWO-COMPONENT SENSOR PPRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="6">
        <location>
            <begin position="421"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1347" mass="145862" checksum="71FE160548EF6FEE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7K5</accession>
    <name>A0A0D2U7K5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349029.1">
        <property type="nucleotide sequence ID" value="XM_004348979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7K5"/>
    <dbReference type="STRING" id="595528.A0A0D2U7K5"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7K5"/>
    <dbReference type="OMA" id="FNSRRVW"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7K5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03187">
        <property type="entry name" value="GST_C_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034347">
        <property type="entry name" value="GST_Phi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="23759" checksum="5618C93D8810EF7D" modified="2015-04-29" version="1">MSLPKIYGSRFSTCGQRVMTALYEHNVEFEVVNVSVTELKEPAHLARQPFGQMPAFEDADGFQVFESRAIAHYIDAKYKGQGNTLLPEDIKQAALVEQWLSVEYSNFNPSAGAIVKETVFKPVFYKIEGDMAVAEAEAAKLAKILDVYEQHLSKNEYLANNQFSLADLAHLPYGQHLVRGPFGHLITSRPNVNAWWNRISSRPSWQKAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8B6</accession>
    <name>A0A0D2U8B6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8B6"/>
    <dbReference type="InParanoid" id="A0A0D2U8B6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="51199" checksum="306122C2592FB708" modified="2015-04-29" version="1">MEAPRTSPDFTSLPEFYKDTVFKIYKREHPTLDLTTLANAARSQFNPQPIIIERAAYFLFTVARADHASTLALSGIMVGKATIRPSTPVFTFQVHFRNCPYATPAENLCKMFSKALGINFSELKFTLTKDGFNDGSGHLVAFGDESQLKEYAKRVPYSIAIGKEDHVFLSCKNQLHGCCYCKTTEHTREKCTQAPACSWCLGEGLSGHHNPRFCSHNPSKLKRKRSSRSSARPHRTAHAASASQSSQPSTSASATSTSSLAPSQSNAQALLSSATAPGAASNVAARQAASSSSAAAPAAAAPAASAAGPSAPSGAPASASGPSRTVPSAAPTAPAAAPADSTATRPRANSTGAAVAHPRPSGASTPSASSRTPSASSTPTVSRSRAGSISIFPQWPPPSSASTPFSAGVHTAMHPSTASQSQSEGLATPSSTRVRLRSADSSPSGHANKAFRADPSESTTHVEQSSSQVTSLPPDQSSAPPGAPDQDVGSSNQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8Q6</accession>
    <name>A0A0D2U8Q6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349338.1">
        <property type="nucleotide sequence ID" value="XM_004349288.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8Q6"/>
    <dbReference type="FunCoup" id="A0A0D2U8Q6">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U8Q6"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8Q6"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8Q6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="309" mass="34843" checksum="FB48139C5EA27E9F" modified="2015-04-29" version="1">MAFNPYQQPTQPMNGLPQFSPFFANNNNNPNPSNPMMMAGQQQQQYAQGQQQMDFGNGNQLFSTMMSQGQAFMANPATNLALQHGFSVAENYVGKNLSRFVTINKLKYYFAVNTSYVARKLRLVLFPFLNRDWSRKHGTDPSTNSISFLPPRDDVNAPDLYIPVMAFVTYVLLVGFWLGVQNKFTIELLGMTASSALVWYIFEVAAMSLSMYIMNINCPIQTMDLMAYCGYKYVGMIVTIISMFVLNSLGSSAVLLFCCLSLSFYLVKTLRLAMVDEGGAQDHGYKRRTYFILSIVAAQVLLSFYLTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA89</accession>
    <name>A0A0D2UA89_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA89"/>
    <dbReference type="InParanoid" id="A0A0D2UA89"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="230" mass="24477" checksum="4CF2EFD77B1A0CDB" modified="2015-04-29" version="1">MKIRVVRSHLVRSRDAADTVTANANANATATDAADAAGAAQAKAQGVVAQVSPQLFEFSPLDQVGTGFQRVQCAWFYKTKLDADRMRIALALVLPRYPHFAGRIIAWKPRKHTSSDPSYAAAIAASHPTYRPKFGYAINDAGIPFDEAVIHGMSTGDLSWERTRVSDSFEVARAVLIPKAGDAVCSVQLGEFADGSGTALSVTTVHSVVDGQPVANPGSSYFPSQSTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAA5</accession>
    <name>A0A0D2UAA5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363867.1">
        <property type="nucleotide sequence ID" value="XM_004363810.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAA5"/>
    <dbReference type="eggNOG" id="KOG2059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAA5"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21669">
        <property type="entry name" value="SMP_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="557"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="630"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1328"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1456"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1458"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1590" mass="168654" checksum="224E5972D08ED06A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAZ6</accession>
    <name>A0A0D2UAZ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364068.1">
        <property type="nucleotide sequence ID" value="XM_004364011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAZ6"/>
    <dbReference type="InParanoid" id="A0A0D2UAZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="125" mass="12079" checksum="A1F54A728B38F31B" modified="2015-04-29" version="1">MSGQFSIDDDDENELLGTPAPALAPSTTLSAAATTAASARAASNAAAAAAAAIASGTEMSAEEEEALLLGESAPSSKPSTPAAAAAAAPAATTTTNAVAVHDGEADVEAVDEEAPAETPEQRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB67</accession>
    <name>A0A0D2UB67_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB67"/>
    <dbReference type="STRING" id="595528.A0A0D2UB67"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UB67"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UB67"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="112"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="287" mass="31360" checksum="B0D63948BD7842DF" modified="2015-04-29" version="1">MTDFAHLLPPSWKTTVTQWLDEDIPSFDYGGFVVGEKEETAELLGKSPGVLAGVPFFEEVFRQVDCKVHWLVKEGDFVDGKRVRVATVTGKARNILLGERAALNMLARASGIASRARELRKLKDEKGFKGVVAGTRKTTPGFRLVEKYAMLVGGVDTHRMDLSSMIMLKDNHVWSQGSITNAVRRAKTVGGFALKIEVECRSIDEAREAITAGADIVMLDNFDPEALKVAARILKQESPHVLIEGSGGITSETLASYFDDAVDVLSMGSLTQGVPHVDFSLKIVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF21</accession>
    <name>A0A0D2UF21_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348273.1">
        <property type="nucleotide sequence ID" value="XM_004348223.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF21"/>
    <dbReference type="eggNOG" id="ENOG502RZ4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF21"/>
    <dbReference type="OMA" id="TFSKQQY"/>
    <dbReference type="OrthoDB" id="411535at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="190" mass="20822" checksum="4A9B909A3D6E145F" modified="2015-04-29" version="1">MARESESVRHAGGRFASVLDAGDAASHYVPDNEFYSVVAAILRETDWTEPWLVGLLSFHVFNVIVALFARRHSTFQATYFCVLMVLAYSTEHLNKWAVDNWQQFSAKAYFDVHGLFISTVFAGPLLLTSLLFVVVWMKTAADLLVKVKRAELRTRARAARSDGAQTAAGASSAGSGSQSIATNAESKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFI7</accession>
    <name>A0A0D2UFI7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347361.1">
        <property type="nucleotide sequence ID" value="XM_004347311.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFI7"/>
    <dbReference type="STRING" id="595528.A0A0D2UFI7"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFI7"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFI7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="463"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="823" mass="87993" checksum="C4165E128C526A2E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFN8</accession>
    <name>A0A0D2UFN8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347407.2">
        <property type="nucleotide sequence ID" value="XM_004347357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFN8"/>
    <dbReference type="InParanoid" id="A0A0D2UFN8"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="381" mass="41466" checksum="3D786E863EA62B84" modified="2015-04-29" version="1">MQPKILVVGQTLSALAVTASLRSRGCHVLRARTRDNPTMTTTTEGRPGHALVLTPAAPMLKIVQEIRNAKDAHKHQALSDTSICEILTGGGESFSFRGHRITAIESELLAVVDRQRLASMLQEQCHGVQEVQMDHIDPSQFDLVVHTTGSFHRSESKALRPGMTMVAGVIPPGRFSEHEAARICPPRTLRVWGFDATVVAMVQDGQGTIQWHSLLPLHDAPLAAQINDAAQRSLNYLHDSVFSGLWDDRIRAAISATPSSQFLTRSLSADPVHVHMQPPGTSSKASSNPILSVSLGRAAVEYPPLGIQPLLHTFKAAVSLATTVANSSLDMLRPNIARYVATQTQQTAALVRRGERFATILQHAEDTEISLEYSFVTSMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJL7</accession>
    <name>A0A0D2UJL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-secretase-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJL7"/>
    <dbReference type="STRING" id="595528.A0A0D2UJL7"/>
    <dbReference type="eggNOG" id="ENOG502QWQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJL7"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="759" mass="83216" checksum="4DDA65CBE75DC018" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK75</accession>
    <name>A0A0D2UK75_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UK75"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UK75"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UK75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1962"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="568"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="850"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1543"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1682"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1818"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1996" mass="212497" checksum="8B7FAF7818EC7B60" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM21</accession>
    <name>A0A0D2UM21_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345224.2">
        <property type="nucleotide sequence ID" value="XM_004345174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM21"/>
    <dbReference type="STRING" id="595528.A0A0D2UM21"/>
    <dbReference type="eggNOG" id="ENOG502RWZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UM21"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UM21"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="45071" checksum="7CB83DD896FE0A8C" modified="2015-04-29" version="1">MTERSPLMEQDEHATNFAIANPPASYQRQSSSSAAAAASAATTTTTAAAAAGNAGASASASASAATGRRSGPPLSRATSNSASAARLSIPGSRRSGATSAAAAASGGGGSGGVPDEPLPSYETVTGNAPPPTYESLFGRIRDERDRSGIGANFILRVVILLIGTIGVSVMGALFLGIPISMIVIGAVKWDAPCDTDHFRIFLIVGGTCGLATNLYSLCCKKKRRDENGELIPEEPTLLGRLMTLTEVFELGWFIVGNVWVYSYDTGDDYANCDKTLFLFTFWIVTTFYLILGGILVLFCLLICVLSCYGRSVRQQQAADDDAPSEHGDDGDDDDDRDDGQNHDGEDEHGSPPGSSAGAGSGRASVARLPEMTTAPLTTNGSFSSTSLAREASVTRSSVPRDAVAVGMPQSAPSSPNTPGAGDNDEPPPPSYDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ93</accession>
    <name>A0A0D2UQ93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ93"/>
    <dbReference type="InParanoid" id="A0A0D2UQ93"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQ93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="110591" checksum="070649FF0DC630E1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTY5</accession>
    <name>A0A0D2UTY5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346440">
        <property type="protein sequence ID" value="KJE98451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTY5"/>
    <dbReference type="InParanoid" id="A0A0D2UTY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="265" mass="27668" checksum="12BCDBF70B55F737" modified="2015-04-29" version="1">MRANVRPNVVSRFRAEFGLITGHQGPWTRAPPLAYNANSITCNGEVDVAVHAVAELGEEGDAVTRNRSPHIDVPSPLFLCSSAFPPKPEHTRPTSANQQPNANPEMTGPPKTSGTGPGQPAIASALAAAAQHQQRASRTASPSSQVDMTSNDPVSVLPTATSGGNAGLNLNLNLILLLLLLLHCLLFLICRNHHCDQRPQPPLRPAPGLASAPAPAAAAKAPPPATGTLSQPTPETILTPTPKPKLPRCPLKKPGSSLKTQAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG15</accession>
    <name>A0A0D2VG15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269970.1">
        <property type="nucleotide sequence ID" value="XM_011271668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG15"/>
    <dbReference type="STRING" id="595528.A0A0D2VG15"/>
    <dbReference type="InParanoid" id="A0A0D2VG15"/>
    <dbReference type="OrthoDB" id="5875376at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="456"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="810" mass="87043" checksum="F75E2A12F0EF6E8A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIN6</accession>
    <name>A0A0D2VIN6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349792.1">
        <property type="nucleotide sequence ID" value="XM_004349742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIN6"/>
    <dbReference type="FunCoup" id="A0A0D2VIN6">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VIN6"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIN6"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="70" mass="8111" checksum="D6464C8AAE9AC830" modified="2015-04-29" version="1">MITPVRCFTCGKVTGNKYEAYITLLAQQTISEGDALDALRLKRYCCRRMILSHVDLIEKLLRYNVQDRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK94</accession>
    <name>A0A0D2VK94_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK94"/>
    <dbReference type="InParanoid" id="A0A0D2VK94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123588" checksum="E3B46F5B1FE00477" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL66</accession>
    <name>A0A0D2VL66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5898 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL66"/>
    <dbReference type="eggNOG" id="ENOG502ST1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL66"/>
    <dbReference type="OrthoDB" id="2137386at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VL66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045417">
        <property type="entry name" value="DUF5898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34871:SF1">
        <property type="entry name" value="DUF5898 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19250">
        <property type="entry name" value="DUF5898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254307" description="DUF5898 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5898" evidence="3">
        <location>
            <begin position="566"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="723" mass="79349" checksum="CC792EF9109099DB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLG4</accession>
    <name>A0A0D2VLG4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-like protein Rab-11B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348926.1">
        <property type="nucleotide sequence ID" value="XM_004348876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLG4"/>
    <dbReference type="FunCoup" id="A0A0D2VLG4">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLG4"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLG4"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="216" mass="24053" checksum="013029DAB4A0C07D" modified="2015-04-29" version="1">MATKDSDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADANIVIMLVGNKSDLRHLRAVPTDDSKSFAEKNNLSFIETSALDATNVELAFQNILTEIYHIVSQKTIVNDDHVAKVPTSNVQTITVAPSEATDDKKKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMM2</accession>
    <name>A0A0D2VMM2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349313.1">
        <property type="nucleotide sequence ID" value="XM_004349263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMM2"/>
    <dbReference type="FunCoup" id="A0A0D2VMM2">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMM2"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMM2"/>
    <dbReference type="OMA" id="RYSVRVW"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMM2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="336" mass="38138" checksum="BD450BF866D4F7E8" modified="2015-04-29" version="1">MASTSPFRDPIPDIDIDSIIERLLAVRGSRPGKAVQLGEDEVRGLCLKAREIFVQQSILLEIQAPLKVCGDIHGQYYDLLRLFEYGGLPPESNYLFLGDYVDRGRQSLETICLLLAFKIKYPENFFLLRGNHECASINRIYGFYDECKRRYSVKIWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLQSMDQIRKIQRPTDVPDTGLLCDLLWSDPDKDVAGWGENERGVSFTFGPEVVSKFLLKMDLDLICRAHQVVEDGYEFYAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAEKKTKYAYNGPSNGDRPMKPPRNSKKKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNH5</accession>
    <name>A0A0D2VNH5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363778.1">
        <property type="nucleotide sequence ID" value="XM_004363721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNH5"/>
    <dbReference type="STRING" id="595528.A0A0D2VNH5"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNH5"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22139">
        <property type="entry name" value="F-box_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="558" mass="60329" checksum="214BF9E1AAA2182F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNM7</accession>
    <name>A0A0D2VNM7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363828.1">
        <property type="nucleotide sequence ID" value="XM_004363771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNM7"/>
    <dbReference type="STRING" id="595528.A0A0D2VNM7"/>
    <dbReference type="eggNOG" id="ENOG502SBKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNM7"/>
    <dbReference type="OMA" id="SQFTYWN"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNM7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052863">
        <property type="entry name" value="RNase_H2_subunit_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47063">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47063:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="15038" checksum="97668867ED6A2B23" modified="2015-04-29" version="1">MEITVEHNTRAAQLAMHSLPCSIDHNGPANISSYFLVESDTASGVHAAKFRGRQLAGITAQVPSGLVGALLRESRPALTDQEARTLDVAGQFREFTLWNLETPPTAQADMMRALHAIEVAAILHGNDDDPQPPQSETPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS90</accession>
    <name>A0A0D2VS90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="16">2.7.7.1</ecNumber>
            <ecNumber evidence="16">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_004639</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="16"/>
    <dbReference type="EC" id="2.7.7.18" evidence="16"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS90"/>
    <dbReference type="FunCoup" id="A0A0D2VS90">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VS90"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS90"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS90"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 16" id="KW-0520">NAD</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 16" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE93922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="229" mass="25837" checksum="B36FD579FA00D889" modified="2015-04-29" version="1">MPVQRAVLLACGSFNPITNMHLRMFGKSIHSSIDRLDSTGRFKVVGGVISPVNDGYKKDGLLAASHRLAMCRASVANSTWIRTDDWELTNPEWQRTVSVLRHVRAQVNEGVSAEDQIRVKLLCGADLLESFATPGLWAVEDLLEIVGEFGIVCITRMPSDPFKFIYESDLLHAHSHNITIVHEHIRNEISSTHIRRHIRRGLSVRYLIPDAALDYIQQNNLYLEAKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVD5</accession>
    <name>A0A0D2VVD5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVD5"/>
    <dbReference type="STRING" id="595528.A0A0D2VVD5"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVD5"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVD5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="177"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="392" mass="43134" checksum="5285AA29C57423B1" modified="2015-04-29" version="1">MLVVISVPLTVEQDQTLGITNIQTLLPALRRDLRASHPLIGKESRILVQLLPEAPTHDNTDAQAPQLCALWHRVPWEQMKKFLSCAYEAFMDASNPVQRIEISLLGFAAFNIPLSKSDSRIKRFGRVNAAKDGWNLASVPDAQWTREMKLVPKETKPFDAASSLTSSNWPVADDVCLGGTFDHMHNGHRILLTVAVLLARRRLVCGVTDGSLLANKKRKELVEPLQQRINAVRDFCHVIRPDLAIEFHAIVDMYGPAGTDADLDLLVVSEETKGATPLINEKRSANGIPKMLKPELVELVQSDLHSAEKLSSTQIREWIAHTSTEGAKPPTGQAITVQRVGRTGHIEKSKTQGSRKPRGAAAIIAPVLSQSPEALASGRVLRPRRTSTTQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW08</accession>
    <name>A0A0D2VW08_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345694.1">
        <property type="nucleotide sequence ID" value="XM_004345644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW08"/>
    <dbReference type="FunCoup" id="A0A0D2VW08">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VW08"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VW08"/>
    <dbReference type="OMA" id="KIDNTRC"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW08"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000003">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="32"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="334"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="503"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="675" mass="73973" checksum="B7237CFE8B07E0CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXQ8</accession>
    <name>A0A0D2VXQ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_010023</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXQ8"/>
    <dbReference type="STRING" id="595528.A0A0D2VXQ8"/>
    <dbReference type="eggNOG" id="KOG2196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXQ8"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VXQ8"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="14">
        <location>
            <begin position="698"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="899" mass="90804" checksum="A641EA5A4DC2D38F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYP4</accession>
    <name>A0A0D2VYP4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional adapter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343846.2">
        <property type="nucleotide sequence ID" value="XM_004343796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYP4"/>
    <dbReference type="FunCoup" id="A0A0D2VYP4">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYP4"/>
    <dbReference type="eggNOG" id="KOG0457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYP4"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYP4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="12">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="453" mass="50692" checksum="AD64FCA8E3D78A36" modified="2015-04-29" version="1">MSLQSNTARAPATTATLPTAARTTCKACTKDTTNTPYIQCAECENVQLCVNCFTQGVEVEGVTCNHRNTHDYRVIDNYQYPVLEAGWTAQEELALLDAIEHNGLAWEYVSEALATKTAQECETHYAKFYLCHSQAPLPDTRKLLCRHLILPATSELDEPVADIPFSGTQTEASSLISTAPKSLGPEVAGFIPLRGDFEVEYDNTAEFLVKDVVFNDEDSDLERRVKLELVSMYNEHLDERLARKEVVRAHGLLDRRNVAHPNTEAERQLRNQLIGLARFQSFEQQEGFIQSLLLEQRLRKRLDQLREYRANGVRTLAAGKIHDLEKAKRASEKSRKASRPTPSFSSLVTANSRYPSSSSSSSSAAKAMVISNLPGYDQLTEDEKEICVTLRFAPNQYLSLKSTLVSACEANDGLRLIDARGLIRIDVHKTRRLWDFGISSGWLWSSTSKQSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYX7</accession>
    <name>A0A0D2VYX7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYX7"/>
    <dbReference type="InParanoid" id="A0A0D2VYX7"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="832" mass="91356" checksum="6927BB765C34937E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZ74</accession>
    <name>A0A0D2VZ74_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343427.1">
        <property type="nucleotide sequence ID" value="XM_004343377.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZ74"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZ74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1464" mass="159130" checksum="C7CC908A07E4CAD4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZA6</accession>
    <name>A0A0D2VZA6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_010081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZA6"/>
    <dbReference type="STRING" id="595528.A0A0D2VZA6"/>
    <dbReference type="InParanoid" id="A0A0D2VZA6"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZA6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000031">
        <property type="entry name" value="Probable copper-transporting ATPase HMA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="400" mass="42335" checksum="C48F0B72C6EA66EC" modified="2015-04-29" version="1">MNASPALFAIVTFITVMVIACPCALGLGTPTAVMVGTGVGASNGVLIKGGEALEKAHKTSAIIFDKTGTLTHGKPAVTHLRFLGASSSLSSEAQFEDWLVCAESGSEHPLGRAIVQHLQAKNPAAASIDASRIGGFRAVSGRGLECVVDGSRHIVVGNRAWMTENNVAISEAVESDMVALEGQGHTVMLAAAGATTSAATPTFELLGFVAVADTIKPETRSVVEMLRRQKIEVWMVTGDNERTARAIAQQAGITNIFAQVLPADKAEKVKELRAQGHTVAMVGDGINDSPALAEADVGLAVGAGTDVAIEAADMVLLKSDLRDVIVAFDISRKTFRRIQLNFVWAYGYNIIAIPLAMEILYPFTGWVFPAWLAGLAMAMSSVSVVMSSLALRWYRKPRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0W7</accession>
    <name>A0A0D2W0W7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 8">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 8"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343063.2">
        <property type="nucleotide sequence ID" value="XM_004343013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0W7"/>
    <dbReference type="STRING" id="595528.A0A0D2W0W7"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0W7"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0W7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="11">
        <location>
            <begin position="737"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="817" mass="91790" checksum="2274BBED4FD958E0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGB5</accession>
    <name>A0A0D2WGB5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269956.1">
        <property type="nucleotide sequence ID" value="XM_011271654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGB5"/>
    <dbReference type="STRING" id="595528.A0A0D2WGB5"/>
    <dbReference type="InParanoid" id="A0A0D2WGB5"/>
    <dbReference type="OrthoDB" id="2411356at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGB5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45651" checksum="CAD5FD14421CF522" modified="2015-04-29" version="1">MSAAAPAAAPAAAPAQQQPAFRGVFGFIGGVVANAVSSIFIIMVVAAFVAQHVLDHKNTIAKTHSPEIVLARMLARFEAGSVIPPIEGYHVSRPDAVAMLQAVLRPNKVTRYPVVVGETGCGKTSAVLDAIRPNRTGIVYHIVGAELLVDVPKRLAGSLAFEFNQFTFTAGYFKDRGVEMEQVTSAAEPFKSWAILDLSLRDVAAQFKAKHGHVATLVIDAVDEIDKQGSELLHAIQKFAKSAADEQLLNVVLVTCDGSNLPALKESSAMTRARVVEVGDLTDQQAVTYLVRRDIHEDLAKRAVAEIAGGRLILLNNLADDLQFKTVEQISTQLSIQTADSLQDVIDYSEMHNATSAVHKSLCDLTHGALHINIVHRSLGKDLTKKLLATNINILAYHPNDTYTLHSRHVQRSVAALLNCTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGV1</accession>
    <name>A0A0D2WGV1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGV1"/>
    <dbReference type="STRING" id="595528.A0A0D2WGV1"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGV1"/>
    <dbReference type="OMA" id="NIWHEPQ"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="545"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="707"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="938" mass="105157" checksum="45F5D05EB1CCE9D7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI75</accession>
    <name>A0A0D2WI75_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365109.1">
        <property type="nucleotide sequence ID" value="XM_004365052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI75"/>
    <dbReference type="FunCoup" id="A0A0D2WI75">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WI75"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI75"/>
    <dbReference type="OMA" id="HMENIEE"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="43287" checksum="4338D4F9AEAE86F3" modified="2015-04-29" version="1">MHLITAGLWLGDILDFSMVRFSTLTRDPSLIAPNYCQVTHVLSMTKVDAQIAPVLETYPSAAGPGEHPLIADYRKASDFAAQRSAAGKKGSGSRGAADVTNPSNPSGIVRTRPVTHKQCVIQDTESEDLLRVIPECVGFIHEALRANANGVAENVVFVHCAAGVSRSASIVLAYLAYTSFSSAEPLTYDRALKIIQQARPIARPNLGFEAQLRVFIASRGKVDRSTPDYKWQALRMVHMENIEEEPFDIVIDRYLVHVALQNREKLGHLPDADADDFFVRCKHCNHRLCSALAMIGHGLGSLPVELASPVSSDHRGTAACEYLFVEPQDWMRKTEASQEGPTHLLCPRCSATIGDVDWQDGLVCACEHLVRPGIAFRRDQLAHIPRALYPSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIF7</accession>
    <name>A0A0D2WIF7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIF7"/>
    <dbReference type="InParanoid" id="A0A0D2WIF7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="120" mass="13174" checksum="2B6B9B896E2D5F83" modified="2015-04-29" version="1">MPLTTTPTTPTVCLSGVETLTCQTQNVASRVQQSQEPEPVVMRQNRARTNHSRSWMRAVTRTEASAAPRQGVPEQREPQRLTGHLPGGAPGSWATAGVAARRVRSGQRTRCLRCSPSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIU1</accession>
    <name>A0A0D2WIU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365477.1">
        <property type="nucleotide sequence ID" value="XM_004365420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIU1"/>
    <dbReference type="STRING" id="595528.A0A0D2WIU1"/>
    <dbReference type="eggNOG" id="KOG2377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIU1"/>
    <dbReference type="OMA" id="CSTHHNG"/>
    <dbReference type="OrthoDB" id="26384at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="591"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="809" mass="89925" checksum="D94A89E035D70FE9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ97</accession>
    <name>A0A0D2WJ97_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ97"/>
    <dbReference type="InParanoid" id="A0A0D2WJ97"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="413" mass="43179" checksum="59D6C02726251C39" modified="2015-04-29" version="1">MSANESSSRGAAASARAAACTLGCAAAAVGSGWSAEPASSARDRSAAISASRSCCNAWLLCSSCSTRFEYESRAARAFSSCSFRSADCWSFFSRLLRAALRLLSFRLASLSSTGKLAPPVDVAEDAGWRRELEEVGAGAIGTGEVAVAAAAAAILPLQLLVRVRLLAGVANSSTSSKMCLARELATLVAANSVSSNVSSAMDRESGTDLCVNMSASASRNSELNSCWCAWKDAEEAEEDEDEGLAVVRIGPFISASRSSSSSWPVQSCISSQSDADETELADSGDRMGETRSCSIIWTIKCDDVVGVVVGVVKARAAEPVPASTSANALASPSSSSSKLLALSLYGMSAADCCSVMLFHRYVWGVGVLVFLLVLLFLASFFFLFFFVLLVFLVVCCCPSLVAISLTTDNKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJB3</accession>
    <name>A0A0D2WJB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270025.1">
        <property type="nucleotide sequence ID" value="XM_011271723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJB3"/>
    <dbReference type="FunCoup" id="A0A0D2WJB3">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJB3"/>
    <dbReference type="MEROPS" id="T01.990"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJB3"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="208" mass="23088" checksum="1A692FB8BB25FA62" modified="2015-04-29" version="1">MPGRTVVAVAGENFAVVASDTRLSEYYGIHTRNCPKTFVLSDKTVLASCGFHGDVLTLTKNIFTRLRKYEHQHEKTMATHAIAQMLSNTLYYRRFFPFYTYNVIGGLDESGKGAVYSYDPVGSYERESYRAAGTASALLQPLLDNQLGYKNLAPNVPRPPLTVARAVAIVKDVFAAATERDIYTGDSVDIQVITSEGVATERYELRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJE0</accession>
    <name>A0A0D2WJE0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364342.1">
        <property type="nucleotide sequence ID" value="XM_004364285.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WJE0">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJE0"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJE0"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="555"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="734"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="885"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1312" mass="142970" checksum="21F5EC21F25BABCF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJG6</accession>
    <name>A0A0D2WJG6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ash2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364393.1">
        <property type="nucleotide sequence ID" value="XM_004364336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJG6"/>
    <dbReference type="FunCoup" id="A0A0D2WJG6">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJG6"/>
    <dbReference type="eggNOG" id="KOG2626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJG6"/>
    <dbReference type="OMA" id="HEENFRI"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJG6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="351"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="818" mass="86719" checksum="93AE03CDE5292CE4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJH5</accession>
    <name>A0A0D2WJH5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364410.2">
        <property type="nucleotide sequence ID" value="XM_004364353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJH5"/>
    <dbReference type="STRING" id="595528.A0A0D2WJH5"/>
    <dbReference type="InParanoid" id="A0A0D2WJH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269969" description="ATP-dependent RNA helicase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="240"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="837"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="906" mass="97286" checksum="9F33821D05049D23" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKC4</accession>
    <name>A0A0D2WKC4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKC4"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKC4"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKC4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1459"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1648"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1468"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1667" mass="182348" checksum="D752DB54FF7E8345" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKF8</accession>
    <name>A0A0D2WKF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364306.1">
        <property type="nucleotide sequence ID" value="XM_004364249.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKF8"/>
    <dbReference type="eggNOG" id="ENOG502QQRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKF8"/>
    <dbReference type="OMA" id="FNTHRRV"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20760">
        <property type="entry name" value="capping_2-OMTase_Mimiviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="585" mass="64597" checksum="9F234B3C88AF72A0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKT3</accession>
    <name>A0A0D2WKT3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKT3"/>
    <dbReference type="STRING" id="595528.A0A0D2WKT3"/>
    <dbReference type="InParanoid" id="A0A0D2WKT3"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254535" description="HPt domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="88"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="194" mass="21813" checksum="27EE9C4329A40FC6" modified="2015-04-29" version="1">MWKCGRLTFHFSFLFSFSFCRPKTTLAIMLQSMSLRQADNVSFEFNDCLGLQAQTTVATFTSMAQLDETTSPIIDYESFNAVKECDDDPSFLESIVNDYIEQLESKKVELFDLHQKGELQQFSQVAHFLKSSSATLGVARLRYLFGKLQIFAQEGAQKDPAKVNELVLKVDPLVDEAVAKLKSEVDEAIRAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKT8</accession>
    <name>A0A0D2WKT8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Usp8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002196</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKT8"/>
    <dbReference type="InParanoid" id="A0A0D2WKT8"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="880"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="841"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1286" mass="138675" checksum="3CA69F32E3FFF838" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLU8</accession>
    <name>A0A0D2WLU8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349473.2">
        <property type="nucleotide sequence ID" value="XM_004349423.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLU8"/>
    <dbReference type="eggNOG" id="KOG1797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLU8"/>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLU8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="8">
        <location>
            <begin position="683"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1677"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1806" mass="196856" checksum="EBCE3C0EB22C22DA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM26</accession>
    <name>A0A0D2WM26_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Equilibrative nucleoside transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM26"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM26"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="76914" checksum="227F8AF42491C51D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM47</accession>
    <name>A0A0D2WM47_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349072.1">
        <property type="nucleotide sequence ID" value="XM_004349022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM47"/>
    <dbReference type="SMR" id="A0A0D2WM47"/>
    <dbReference type="FunCoup" id="A0A0D2WM47">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WM47"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM47"/>
    <dbReference type="OMA" id="FRSYFHY"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM47"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000002">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000004">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="296" mass="33099" checksum="BE1F70CE027DAF88" modified="2015-04-29" version="1">MILLEFQNRIIKEALLARVGVDKPDSIDLTVADFDGVTFHISSTGENKSVVQVSISIRCFAELQAHGADEYLKKVYGSNVAPTENGYSFTIALDFDKLPANKDEVINDFALLKRHCLAAPIGKYFDLCDKGGAGGDKTAVISYREDEKIYLNAEKDRVTVVFSVRFRDADDVVLGKVFLAEFVDARKRLNQAPQVLFSKEPPREIAGAGASVADNMSYVTFVLFTRHVKGAERENSISLVQTFRDYLHYHIKCSKAYLHSRMRARVTSLLKILNRARPEPVVVERKTATGKTFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WME6</accession>
    <name>A0A0D2WME6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349221.1">
        <property type="nucleotide sequence ID" value="XM_004349171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WME6"/>
    <dbReference type="STRING" id="595528.A0A0D2WME6"/>
    <dbReference type="eggNOG" id="ENOG502RY57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WME6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36076">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36076:SF1">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25079" checksum="BE45F706DFC5910A" modified="2015-04-29" version="1">MSAQQPPTSTAGQWRSYFDALIDGCYYYTGLPLSHNPSHQARKRIADERRERLHGASIAAPGTSQPQTPSQSPSTSTPDALKQTQSPVRQWTTEADFARRLHESGKPAIVVLSVNGDAFSEQFKPHFYRTAAEFHEAVDFVWVKCVNAQAFCRSRQVITFPHVELYESRPEGEHVPGQPRRYRVSITPFPLHMSYYGLREMLRQKDMLGSFGYRSNGAADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN72</accession>
    <name>A0A0D2WN72_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_002873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN72"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN72"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN72"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE91788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="317" mass="34591" checksum="5355D677800D3C4F" modified="2015-04-29" version="1">MSLHSFNFALISTQQQQQQQEQPPKPKPVVLKPISNIATFAFGGLAGMGATCFVQPFDVVKNRLQVSGAGGNSFNALASILKTEGIAGIYSGLSAGLLRQATYTTTRLGVYNSISERMVAQHNGAALPFVYKLGVGMFAGGVGSMVGVPAEIALIRMSTDGRLPVEKRRGYKNAFDAIARISREEGVLTLWRGATPTVIRACVLNATQLASYSQAKEMLQTYMSMRDGIPLHTGASLISGLLSTIVSMPIDIAKTRLQNMHDKEYSGVLDVWRKTVRKEGVLALWRGFTPYYLRLGPHTVVTFILLEQLNKLYRSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNP2</accession>
    <name>A0A0D2WNP2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="12">LTA-4 hydrolase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNP2"/>
    <dbReference type="FunCoup" id="A0A0D2WNP2">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNP2"/>
    <dbReference type="MEROPS" id="M01.004"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNP2"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="13">
        <location>
            <begin position="470"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="571"/>
            <end position="573"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="617" mass="68413" checksum="F76B15942C0641C5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNS2</accession>
    <name>A0A0D2WNS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363493.1">
        <property type="nucleotide sequence ID" value="XM_004363436.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNS2"/>
    <dbReference type="STRING" id="595528.A0A0D2WNS2"/>
    <dbReference type="eggNOG" id="KOG3047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNS2"/>
    <dbReference type="OMA" id="DAYKPPQ"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="21320" checksum="D5AB3FB331526CB6" modified="2015-04-29" version="1">MEQAPPTPTELSAKIAQYERFVDDKLKSDLQQVESKREQIYAQCAEYLQLKNSLLAICDATGLPSTAAAAAAAATHTGASSSSSFASASASSKVAAGSKASDAAVTPVKTMVDIGCNYYVQAEIPDPSRVFVKVGFGFYVELSIPEALVFIERKTAQLDKSTEALAAESAKIKANIKLTLQALQDLQSIREPSEPRRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPF2</accession>
    <name>A0A0D2WPF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 66 member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PQ-loop repeat-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348383.1">
        <property type="nucleotide sequence ID" value="XM_004348333.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPF2"/>
    <dbReference type="STRING" id="595528.A0A0D2WPF2"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPF2"/>
    <dbReference type="OMA" id="FKMWFFF"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="268" mass="29201" checksum="A697FB310ABDDD13" modified="2015-04-29" version="1">MVDLGDFVGFIAAAFMIFGGVLPYVPQYLAIKQTRNASGFSTFVSLILILANIVRLYFWLGKRFEMALVYQSVVMLVAQLMMLELCVSMRSSSSSSLAFDDLATGSNGSGVAALGASLSSSALSSARRSNANKSPFAIAHLFDPATFWQWSNFQDYTMFLVVFTAALGVVSVMLIQQNWFVELLGVASVALEASLAIPQFLKNWRTKSTAGMSNAMVLGWLAGDVFKTIYFVTRHSPLQFICCGIVQVLVDLAILAQVFLYPSNKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPK7</accession>
    <name>A0A0D2WPK7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347994.1">
        <property type="nucleotide sequence ID" value="XM_004347944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPK7"/>
    <dbReference type="STRING" id="595528.A0A0D2WPK7"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPK7"/>
    <dbReference type="OMA" id="YCTDPKV"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="168" mass="19142" checksum="99D82CC4D9A3B0CE" modified="2015-04-29" version="1">MYTSGARKPLVRIMFDKFDTDKSGFLDSAELKSLCYDLGHPLSPVELDLALKMLDENGDGKISYNEFAQWWQQQDRFNKLTYDEEEIRSVTAAVKYFQHFDKDKSGTIDANEFKALYKDLLKNGFRIGTVEQALSTLDSNGDGHVSLREYVDWLVAVGSIVLKEKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPP6</accession>
    <name>A0A0D2WPP6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363323.1">
        <property type="nucleotide sequence ID" value="XM_004363266.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPP6"/>
    <dbReference type="FunCoup" id="A0A0D2WPP6">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPP6"/>
    <dbReference type="MEROPS" id="M67.002"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPP6"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="OrthoDB" id="10266268at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPP6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE92678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="357" mass="39962" checksum="E5271C846684D114" modified="2015-04-29" version="1">MDADTSNARATFELSNDMTEVSSLDQVFRFNQQEQQQLLQSRPWTKDPHYFKKVKISAIALLKMVMHARSGGNIEVMGLMQGKIDGDTMIIMDAFALPVEGTETRVNAAAEGYEYMVDYMTVIKDVGRLENAIGWYHSHPGYGCWLSGIDVGTQSLNQQFQEPWVAVVIDPTRTISAGKVELGAFRTYPQGYTPPNEGPSEYQTIPLNKIEDFGVHCKSYYALETSYFKSSLDHKLLDLLWNKYWVNTLSSSTLLTNMEYTTRQIADLATKLESLEHKGTKYQVPGSTDSKKEDELSKITRDSSKMSIEAVHGLMAQVIKNALFNCLHHHQHGPQGSEHTHAPASLPSSTSAAMEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPR3</accession>
    <name>A0A0D2WPR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363361.1">
        <property type="nucleotide sequence ID" value="XM_004363304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPR3"/>
    <dbReference type="STRING" id="595528.A0A0D2WPR3"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPR3"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="71"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="93"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="282"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="567" mass="58797" checksum="F1377E0CC81A4217" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPW2</accession>
    <name>A0A0D2WPW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363459.2">
        <property type="nucleotide sequence ID" value="XM_004363402.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPW2"/>
    <dbReference type="STRING" id="595528.A0A0D2WPW2"/>
    <dbReference type="eggNOG" id="KOG2453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPW2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="403" mass="43058" checksum="7D96AB8157EB2C29" modified="2015-04-29" version="1">MGKILPEGEGEVQEYVDICDYAVGLSRIMSGKVIPSERPGHMLLEQWNPMGIIGVISAFNFPVAVFGWNQALALVGGNATLWKGAPSTNLASVAVTRIVADVLERNNMPGAVSSLVCGGADIGQLMAEDKNVNVLSFTGSTRVGREVGLTVQRRFGRSILELGGNNAIIVMNDADLKLVVPATVFAAVGTAGQRCTTTRRLLLHEDIHDTVVERVVKAYKQIKIGSPLEPGVLCGPLHTKAAVQQYKDAIAAAVAQGGKVIHGGNVLERKGNFVEPTIILASPNMPIVKQETFVPILYVMKFKTFEEAVEINNSVDQGLSSSVFTKDTTNLFKWMGPHGSDCGIVNVNIPTSGAEIGGAFGGEKETGGGRESGSDAWKQYMRRSTCTINYSDQLPLAQGIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQC5</accession>
    <name>A0A0D2WQC5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase C54 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363659.2">
        <property type="nucleotide sequence ID" value="XM_004363602.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQC5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQC5"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQC5"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="406"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="762"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE93088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1027" mass="110693" checksum="BD4B121490E44045" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQD6</accession>
    <name>A0A0D2WQD6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_004592</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQD6"/>
    <dbReference type="FunCoup" id="A0A0D2WQD6">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQD6"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQD6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23276">
        <property type="entry name" value="beta-trefoil_MIR_PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="524"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="175"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE93870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="932" mass="104335" checksum="9BF4D44AFCEF1F7F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR83</accession>
    <name>A0A0D2WR83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="23">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_004404</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR83"/>
    <dbReference type="STRING" id="595528.A0A0D2WR83"/>
    <dbReference type="InParanoid" id="A0A0D2WR83"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254587" evidence="21">
        <location>
            <begin position="33"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="786"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE93648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1075" mass="110670" checksum="E14612B3EEC097ED" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRB3</accession>
    <name>A0A0D2WRB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_005058</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cell membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346743.1">
        <property type="nucleotide sequence ID" value="XM_004346693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRB3"/>
    <dbReference type="STRING" id="595528.A0A0D2WRB3"/>
    <dbReference type="eggNOG" id="KOG1226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRB3"/>
    <dbReference type="OMA" id="HNEANCK"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF3">
        <property type="entry name" value="INTEGRIN BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0401">Integrin</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254732" description="Integrin beta" evidence="20">
        <location>
            <begin position="20"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="884"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1025"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE94415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1056" mass="109183" checksum="AB24DD0D48EF56D4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRK4</accession>
    <name>A0A0D2WRK4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRK4"/>
    <dbReference type="eggNOG" id="KOG0930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRK4"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="173" mass="20009" checksum="20DA86090F0F79A5" modified="2015-04-29" version="1" fragment="single">MLRVLAGSQSTARKKAGWLTKQGGSNKGWKRRWCVFENNCLAYFKSEQDREYAGIVYVEDMRSITIDQEESRKDNRYPYCFRVDTPDRAYMFCAESAADMDDWISMFKSVWQEEPRYLTGTLQFATAECFVDSGLRINGAVEASVLSVFSEGITPKQKRKDERGWFIDKQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRQ0</accession>
    <name>A0A0D2WRQ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WRQ0"/>
    <dbReference type="eggNOG" id="KOG3496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRQ0"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13528" checksum="1CDCEC9D6BCA8AC0" modified="2015-04-29" version="1">MGSTRSQLDREPKTAPDHHGILLQHALTSMLPLPLWAFGIKVAGDLLRGGRARDCAVSFFNQAMTEVAPVTTAAAPTEAKKCKPCCACPETKKPRDQCIVERGEANCQDLIAAHKECMKAHGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS20</accession>
    <name>A0A0D2WS20_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA helicase MCM8</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_008824</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270464.1">
        <property type="nucleotide sequence ID" value="XM_011272162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS20"/>
    <dbReference type="STRING" id="595528.A0A0D2WS20"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS20"/>
    <dbReference type="OMA" id="THTVDWQ"/>
    <dbReference type="OrthoDB" id="422555at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17759">
        <property type="entry name" value="MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000007">
        <property type="entry name" value="DNA helicase MCM8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058767">
        <property type="entry name" value="MCM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26065">
        <property type="entry name" value="MCM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="411"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE94138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="857" mass="94012" checksum="D15DA4B927564CEB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS61</accession>
    <name>A0A0D2WS61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346143.2">
        <property type="nucleotide sequence ID" value="XM_004346093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS61"/>
    <dbReference type="STRING" id="595528.A0A0D2WS61"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS61"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024641">
        <property type="entry name" value="HRS_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12210">
        <property type="entry name" value="Hrs_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="290"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="702"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="835" mass="91820" checksum="3425A0849AF5950F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSM8</accession>
    <name>A0A0D2WSM8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine kinase</fullName>
            <ecNumber evidence="10">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="10"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346385.1">
        <property type="nucleotide sequence ID" value="XM_004346335.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSM8"/>
    <dbReference type="STRING" id="595528.A0A0D2WSM8"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSM8"/>
    <dbReference type="OMA" id="TVKPMHE"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSM8"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000297">
        <property type="entry name" value="Uridine-cytidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="29222" checksum="5AC1B30B26ABBB24" modified="2015-04-29" version="1">MAATGPFFIGVAGGTASGKTTVCEMIMSQLGMNDIDHKERKVVILHQDSFYKVLTREQSEDAAREAYNFDHPDAFDYELIVSTLDKLTSGQPAEIPIYNFKTHSREKETILLDKPDVVLFEGILVLYSEQLRKLLHMKLFVDTDADTRLSRRVLRDIAERNRQVESVLRQYLAFVKPAFDEYILPTKKYADVIIPRGADNLVAINLISQHIKKIVNTPASKRSYASAQASHLPSDISASSSGLELKRSVSKDKSEAVRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSX0</accession>
    <name>A0A0D2WSX0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTPase Ran binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345470.1">
        <property type="nucleotide sequence ID" value="XM_004345420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSX0"/>
    <dbReference type="FunCoup" id="A0A0D2WSX0">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSX0"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSX0"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="23592" checksum="FB648CAC27E5D5AB" modified="2015-04-29" version="1">MADDDREEPTTGDDKDEVVESNDVHFEPIVKLNQVEVKTLEEDEDVLFKIRAKLFRFDKPTGEWKERGTGEVKFLQDRTTKMIRLLMRRDKTLKVCANHIVRDDMVLQTNVGSDRAWVWNVVADFADNEPKPETLAIRFANAENAKLFKDKFEESGRNNASNKGQTPAKGDAPSSSSSAATPAKEDDAAKVAEKLGDLKVADKPEGDKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT82</accession>
    <name>A0A0D2WT82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270544.1">
        <property type="nucleotide sequence ID" value="XM_011272242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT82"/>
    <dbReference type="InParanoid" id="A0A0D2WT82"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="523" mass="59457" checksum="7BD112F27348AD35" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTF2</accession>
    <name>A0A0D2WTF2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTF2"/>
    <dbReference type="InParanoid" id="A0A0D2WTF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="203" mass="22458" checksum="0FA8D39FF24ACFEC" modified="2015-04-29" version="1">MGSKGPERRGQVGVDEIRLQRTMQPFQHRLACLASISTLLHVLKDSGIHLGDGQCLDRKAKYFTKHFCHGMALGLFGRLVFVRQKGPSSADVMAIADVTHLRPWNNVWPNAIFEKDTQLLSSLHGVRIGSHASPTKQRVRKQDCTSQEGDSTAIIRSRQFGRGGFVLANALGGLSFFIRVVVGALATLDACHGLRRASHHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTS7</accession>
    <name>A0A0D2WTS7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class-III aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346261.2">
        <property type="nucleotide sequence ID" value="XM_004346211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTS7"/>
    <dbReference type="FunCoup" id="A0A0D2WTS7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTS7"/>
    <dbReference type="eggNOG" id="KOG1403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTS7"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="456" mass="49759" checksum="ACE4F3A75165EEB6" modified="2015-04-29" version="1">MSSNQSDNDETHRGWTYESLSAARQTLISPAVKLSYKKPLWIVRGERQFLYDHNGVEYLDAYNNVCHLGHCHPAVVQAVSKQMAILNTNTRYLHTAIVEYASRITATCPPELSVCIFVNSGSEANELALRLAYAYTRQKDLIVLDSAYHGNTNAVVEMSPYKTDHPDGPRAPSHVHKVVAPDDYRGLYRRDKYAPAELGPLYAKHVEETVRKIEHEGRKVAAFFCEGILGCAGQIVLPPGYLASCYKAVRQSGGVCVADEVQVGFGRAGTHMWVFQTQDVVPDIVTLGKPIGNGFPIGAVITRPEIARALGRLEYFNTFGGNPVACKAGLAVLDAIAAEGFMENARVVGNHLLSSLRALARKHPVIGDVRGMGLFLGVELVLDRHTLEPATALTSRVIDAIQQNDKILLGTDGPFNNVVKIKPPLCFTVADADKVIAAFDSALKQETQNATILAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV15</accession>
    <name>A0A0D2WV15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV15"/>
    <dbReference type="FunCoup" id="A0A0D2WV15">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WV15"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV15"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55267" checksum="C6FA718303A473DF" modified="2015-04-29" version="1">MQVQLWQAPIGGSKQNAGCVFNPALGFLSFTARTQFASPNPQIQYCTKYKLILPLLVFIVHSPFFANYSSSVKSQSIPFTMVKFAVSHNALLVIGMLLTGSINTLSKKAQNQVSSEGIDGTVRTFSKPWLQTFFMFIGESLCLIGLYVQRRRETAARLQMLSASVNQDPFASSYASPDPASSSLLPRTAASKNADVDTSKHVDRITHKRTWRQVLIFLIPTCFDLTGTTLAGIALLYCAASVWQIMRGSIIIFSAVLSVLFLKRTLGPHKWTGLFIVFCGLAMVGVASVLADSGDDSHPTSEVVLGIALNLAGQLCSAGQVVVEEKLIKAANYPPMEVVGREGLFGALISMFVALPIVYFIPGSQPSEVGSHGSYENALDGFVQMYHSGALIAFVVVYVFSIAFYNFFGLAVTKAMTAVHRTLIDACRTVLVWLVGLVIYYGITDSLGEQWTNYSPLEVAGFLTLVFGTLVYNNIVKLPGFKHDVPPPTCSETQPLLSPNLNAGNPQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVH8</accession>
    <name>A0A0D2WVH8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVH8"/>
    <dbReference type="FunCoup" id="A0A0D2WVH8">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVH8"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVH8"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="919" mass="100495" checksum="179FB9FB9C0A1C0E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVN8</accession>
    <name>A0A0D2WVN8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270688.1">
        <property type="nucleotide sequence ID" value="XM_011272386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVN8"/>
    <dbReference type="STRING" id="595528.A0A0D2WVN8"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVN8"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVN8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="56274" checksum="F9DEC739FA624DE6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVX8</accession>
    <name>A0A0D2WVX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVX8"/>
    <dbReference type="InParanoid" id="A0A0D2WVX8"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="12165" checksum="A98E28BD6B3B2CC0" modified="2015-04-29" version="1">MASETGCHHHSSPELAPPVTGHVLPVFQTDQTSSAFMAEHSGWPPRPCLRVGELQLVTLFRSPFSFLLSCCFLPGPEAQWPTFNSSFPLLMHQGLSHSRRSGPPDLGDPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWM1</accession>
    <name>A0A0D2WWM1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWM1"/>
    <dbReference type="STRING" id="595528.A0A0D2WWM1"/>
    <dbReference type="eggNOG" id="ENOG502RS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWM1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="105"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="439"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="529" mass="58844" checksum="10A728FDA450B464" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D8</accession>
    <name>A0A0D2X0D8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365328.2">
        <property type="nucleotide sequence ID" value="XM_004365271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0D8"/>
    <dbReference type="InParanoid" id="A0A0D2X0D8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="619" mass="65436" checksum="5755CA0F2CEE6B7D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0V5</accession>
    <name>A0A0D2X0V5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366021.2">
        <property type="nucleotide sequence ID" value="XM_004365964.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0V5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0V5"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0V5"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0V5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="374"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="590" mass="64402" checksum="E59F0EF05D6DBACD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0W6</accession>
    <name>A0A0D2X0W6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349699.2">
        <property type="nucleotide sequence ID" value="XM_004349649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0W6"/>
    <dbReference type="InParanoid" id="A0A0D2X0W6"/>
    <dbReference type="OrthoDB" id="2642739at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0W6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="476"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="807" mass="87998" checksum="759E62E508F87C25" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Z9</accession>
    <name>A0A0D2X0Z9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_001338</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0Z9"/>
    <dbReference type="FunCoup" id="A0A0D2X0Z9">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0Z9"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0Z9"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0Z9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="250" mass="29001" checksum="900BD9EB925FC949" modified="2015-04-29" version="1">MTRSAHSFILDHPMAGPSSTAAAPAKKPTPLPVKLYLAAYNLVQAAGWSYILYLMIDHYFVQQKSYNTLYPVVEQALAIFQTGAILEIIHAIVRFVKSPVAITFVQVYSRVFLVWGIAHSVPETQPHWAFTLMLTAWTVTEIIRYLYYFFNLFGSVPYILTWCRYTFFYVLYPMGVSGEVIMIFQAMPVVERNKLFSTELPNWYNFSFSYYYFLIVMAITYVPGFPPLYQYMIKQRRTIIGGKTDKRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1M4</accession>
    <name>A0A0D2X1M4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1M4"/>
    <dbReference type="FunCoup" id="A0A0D2X1M4">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1M4"/>
    <dbReference type="InParanoid" id="A0A0D2X1M4"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1M4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="52"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="210" mass="23106" checksum="FFDB12D810EC188A" modified="2015-04-29" version="1">MWGGCVCVCVHGTGGREAMELALHYALNHAPGTHAALGLLYQHQVFEKFFMVLIPRLNNKRILHDWDLWGPLILCVTLAMMLRDTARDDQKSLVFSGVFVIVWCGAAVVTLNSKLLGGTLSFFQSVCVLGYCLLPLVAGTLIIRTLALMSLASVPVRSVVVLLGLAWALFASMGFLGDSQPVNRKALAVYPMFLFYFVISWLIFVQPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2L4</accession>
    <name>A0A0D2X2L4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2L4"/>
    <dbReference type="STRING" id="595528.A0A0D2X2L4"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2L4"/>
    <dbReference type="OMA" id="THASPWS"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2L4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="220"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="488" mass="53736" checksum="7E6C4E2379E1370E" modified="2015-04-29" version="1">MRNRLHEIDDFAARAIAEALKLNTTLTTLVLSENQIGDAGAQSIAEALKVNTTLTELRLEFNQIGDAGAQAIAEALKVNTKLGTLYLRQNQIGEVGALAIAEALRVNKTLALLYLESNFLTKAEIIALRQTGNTCHLKALDNQRTRSPAEQAAVAKNQQLRTELAAKEQELQQLRSDLKSALDRIDALERHQPADGFASNVDQPIPEVPLATLVSATKNFADDSLLGEGAFGRVYRASLPGPPVAIKKLSAESIKGYASFQSELDSLSKFRHRNIITILSYAKSHDAYCLVYEFMPNGSVRDRLSRKNNTPPLTWSQRHQIAADVDRGMHYVQTALPDQVLFHLDLKTDNVLLDAHFNAKVSDFGLVRAAEHLDDKSYLRTKVPQGTAPYMCPEFFEEGRMTVKTDVYAFGMILLELATAAKPGTRLKAETRKAVSNQKFIEMLDSALKPSDAEHQSITGIVTLALKCLDDIADERPSFGRLIATLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q2</accession>
    <name>A0A0D2X2Q2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363554.2">
        <property type="nucleotide sequence ID" value="XM_004363497.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2Q2"/>
    <dbReference type="eggNOG" id="KOG0618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q2"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Q2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="170"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="425"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="1596"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="1717"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1773" mass="190352" checksum="FE02A1513BD36098" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T8</accession>
    <name>A0A0D2X2T8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2T8"/>
    <dbReference type="eggNOG" id="KOG0248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T8"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="424" mass="44585" checksum="9519CDB173127B16" modified="2015-04-29" version="1">MSLKSGYLTKQGGSVKASYCAAISWKRRWFVLQPAGLTTPASLQYFKTDRAALQANAEALGTISLADVAEVRKADADPEVAGKRFAIACVTPSRTYWLVADSESEMNDWLSILTETLAATAAQSPSSLSQPAGVASILAAPIVHEGYLTKQGGSVKTWKKRWFVLRGNAILYYRTQDAKTPLGIINLAASIGTAEISIPGHQFAFEIATRDRNYLCVASFKDELDGWLDAIRRVSDGSHASGIEHLTFQQVQATNSNGASAGTAVTNGSLDISDLLAQGEKILGSDSEEEEAPKSDSAAVAEVAPRPVAPPRNTSLNKHDLQAVAVREKLAQMGPPSPSTLKAPEVDAILAASVEEPAEGASSSNPFETISTMLTKVSGSLDESAPSSETATLGASAPACIDSRASIAPSSAAMDEMNSLLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3A5</accession>
    <name>A0A0D2X3A5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HLA-B associated transcript 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347425.1">
        <property type="nucleotide sequence ID" value="XM_004347375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3A5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3A5"/>
    <dbReference type="eggNOG" id="KOG1553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3A5"/>
    <dbReference type="OMA" id="PRQEQNA"/>
    <dbReference type="OrthoDB" id="6412627at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3A5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054518">
        <property type="entry name" value="ABHD16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF72">
        <property type="entry name" value="BAT5L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22990">
        <property type="entry name" value="ABHD16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylserine Lipase ABHD16 N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="274"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="578" mass="64353" checksum="7FA8D1EA65422CF9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X444</accession>
    <name>A0A0D2X444_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Geranyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345458.2">
        <property type="nucleotide sequence ID" value="XM_004345408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X444"/>
    <dbReference type="FunCoup" id="A0A0D2X444">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X444"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X444"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X444"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="347" mass="39935" checksum="1D380D94CE516DDA" modified="2015-04-29" version="1">MTMSEQLKQFLAVFDTLVADVMDVAVNQYETPKESQQWMSENLKYNVPGGKMNRGLSVVSTYEILLGRPLTKDELFKAQVLGWSVEWLQAFFLVADDMMDQSQTRRGQPCWYKKPEVSNIAINDSFVIEGSIYILLKKYFRSEPYYVDLLDLLHEVTFQTELGQMLDLITAPEDHVDLTRFTLSKYKTIVKYKTAVYSFYLPVAMAMHMAGVKNPAAFAAAHSILMEMGEFFQIQDDYLDCYGDPAVIGKIGTDIQDNKCSWLVIQALDLANADQRKILEQHYARKDEASVAAVKALYKELELQRVFTEYEEKSFAKLTQLINELDTATIPREVFTEFAKKIYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4C5</accession>
    <name>A0A0D2X4C5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA-damage inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4C5"/>
    <dbReference type="FunCoup" id="A0A0D2X4C5">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4C5"/>
    <dbReference type="InParanoid" id="A0A0D2X4C5"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4C5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000005">
        <property type="entry name" value="DNA damage inducible 1 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="514" mass="56200" checksum="C943DE3C62CEBB73" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4N7</accession>
    <name>A0A0D2X4N7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase-activating Rap/Ran-GAP domain-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344335.2">
        <property type="nucleotide sequence ID" value="XM_004344285.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4N7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4N7"/>
    <dbReference type="eggNOG" id="KOG3686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4N7"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4N7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="134"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="3">
        <location>
            <begin position="410"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="78885" checksum="61EF3B383ED3EE58" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4V3</accession>
    <name>A0A0D2X4V3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4V3"/>
    <dbReference type="InParanoid" id="A0A0D2X4V3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="330" mass="35317" checksum="61C85ACD9D545356" modified="2015-04-29" version="1">MSDDLLDLDALDVSLVASSPLLCGFRPSDGKPVKGQQELRQPQYARLHLLAIDSPVHETVSDKTTDARRIPASTPGMMSPVISSLSAHGNRRRRSSFGIAESVLPDIDLLATETMPVEDHLVTSPERPKTVVLQEDDVLITLKADLVDTLCVSSVTLGSAHNECTQQVENDDEEVFFGPAKPHEQHVASLITRHDQLLVLADQIPTVNNRSSTVHSSRPVSRIRAPKAAAPKPSSLLQELQAGKGPVVALMEQCAQIALLSGMAPVGLESGEAQQRARPLSNGLAANAGSENVNPTAATSKQQEELAPVREPKQAGSGSLRRQEQAGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X531</accession>
    <name>A0A0D2X531_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343443.2">
        <property type="nucleotide sequence ID" value="XM_004343393.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2X531">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X531"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X531"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X531"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="91"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="552"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="688"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1342"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1345"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1488"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1544"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1567"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1590"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1620"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1670"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1728"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1756" mass="191329" checksum="D95D10CA62D487B9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X540</accession>
    <name>A0A0D2X540_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343477.1">
        <property type="nucleotide sequence ID" value="XM_004343427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X540"/>
    <dbReference type="FunCoup" id="A0A0D2X540">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X540"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X540"/>
    <dbReference type="OMA" id="PPKEEIY"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X540"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="410" mass="44139" checksum="10086195C45E9E7F" modified="2015-04-29" version="1">MTAPYIGSRISLISNANIRYEGTLYGINTEESTVTLANVRSLGTEGRGIDGKEVPARADVFEYIVFRGSDIKDLHVQSEPPAFVPQAQQPQDPAIVQVTVAAPAPAAAAAAAAVPVAPAAQQPVVAQQQPQQQPQQQQAWGERPPRFNNQHQSNNNYNNNSSYNNNSNYNNRGNHYNNSNRRGGYQNANMHNTATFGGRPNRAPRADDGSVGILGTPNASVAMAPQSFDGDFDFEGSNARLRKEDLQSEFKDKLKLDDGSAPAAASTSGSTPDAAPAVEDDLLAQPRYNPSKSFFDTISCEVSDRQKEATEGRSHRKNWAQERQTNSETFGTNPNAPRRGYGHRGGEGGRGGRGGRGGQHGGYNNNNNSNNNNNYYHNSTGNPNAGGHHNSRRGGRNNYSNSTGVPTAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5C7</accession>
    <name>A0A0D2X5C7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343271.1">
        <property type="nucleotide sequence ID" value="XM_004343221.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5C7"/>
    <dbReference type="FunCoup" id="A0A0D2X5C7">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5C7"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5C7"/>
    <dbReference type="OMA" id="KRRDYTG"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5C7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="798"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="90322" checksum="FCD9E98E574B3AB5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I6</accession>
    <name>A0A0D2X5I6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270851.1">
        <property type="nucleotide sequence ID" value="XM_011272549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I6"/>
    <dbReference type="FunCoup" id="A0A0D2X5I6">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5I6"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5I6"/>
    <dbReference type="OMA" id="CIINEQG"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5I6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="227" mass="24482" checksum="663100D6AA54D1E9" modified="2015-04-29" version="1">MVTRADGRMPNQLRELSIEHAVLSRADGSSRFSQRDTSALTAVYGPAEVKSSKELLDKATVQTVFRPKTGLAGVDDHVCEAILRQALEPVIQRTANPRTSITVIVQVMHDDGALLACALNSASMALIDAGVPMSAVLAAVTCAWLPAADGSSERRLLLDPTLEEQTAATSIATFAFESTNQEIVFSSTEGQLTVDEYFYTIEMAQKAAANVLAFMRLSLERKFSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5K3</accession>
    <name>A0A0D2X5K3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Intersectin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270854.1">
        <property type="nucleotide sequence ID" value="XM_011272552.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5K3"/>
    <dbReference type="eggNOG" id="KOG1029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5K3"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5K3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="781"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1322"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="147781" checksum="B817657E9A85FEC2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5S5</accession>
    <name>A0A0D2X5S5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346385">
        <property type="protein sequence ID" value="KJE98319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341960.1">
        <property type="nucleotide sequence ID" value="XM_004341912.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5S5"/>
    <dbReference type="STRING" id="595528.A0A0D2X5S5"/>
    <dbReference type="InParanoid" id="A0A0D2X5S5"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="478" mass="53060" checksum="44B34DB1FE293624" modified="2015-04-29" version="1">MLQLVGGRDLVSLSDGEVRALLQSVLAALTPEATLPCLNWTWAQQLLDGTESAVETLAGLVSSVAALVHRVRDNDAAQADLAAAGSRRGGSNSPLATILLTGNAQAIADKPLSYHSPLFYHGTRGYYADLQVGCIMLEQVFGTASLLVTHCSSLGTSLVSGRVPSELGKSVMGRGLQWFPHSLLLRRAWHALRREQGRYQRLLSGLGELAMESGPLGLAFAIEDERTAGSRVHQAGGFDEETESMQGRINRIRAVLARAFDPTSRQCEGQFQSEVRHCVPLWRMFLQFEASCVFREEAAARVRERDLLVTLETKTSGLLERQEGQQLLQAERLRFLQPTSAAAPPQQHQTTGDGAENAELERLKSGFHKRLEDERRRRHRRQRQRLTGVFVRALQQCPWAKVLYLDAIQCGLYRGPLHPDLATQLQMVRNPHDWDDSLQDVVDLMQEKGLHVRTSVEEIEALDHVDAHRANDGSAMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5U8</accession>
    <name>A0A0D2X5U8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346427">
        <property type="protein sequence ID" value="KJE98434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5U8"/>
    <dbReference type="InParanoid" id="A0A0D2X5U8"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5U8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="372" mass="39166" checksum="110F87277BD76972" modified="2015-04-29" version="1">MSGVSNDGATKNANTATKALVGRRGSNPSKPGAVQSTLEAFMGGNGGAGASSGQNDSLPTQDHQIAVPDGMALLNGPRAQPTPTVSRPPTPPNLVGSSGLAVLDSTTASASSAQLPPPGPSAEDEPRPPTRGPSPMRTGEISYAEIVGATLTQLMQTASSEGAASSHRSSAFQPVHATQQAQSQGSQQPQRVQPQPQRQATPAASSSSAPSGEDGSSARKRFREDGNIDETEVNELSPNVDIEASASRTQHKQRKENELQARIKASRAHNNVLILPQFPRPTTQAELKKFAQRIQGIANTKYEVEIVEISAKLGRINLVFESEEHANKMVNELVEINGQSYDLEMAVEGFTISLTGNTAKVDEQAIRNAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9CCD0</accession>
    <name>E9CCD0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346443.1">
        <property type="nucleotide sequence ID" value="XM_004346393.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270540.1">
        <property type="nucleotide sequence ID" value="XM_011272238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CCD0"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CCD0"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="PhylomeDB" id="E9CCD0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="596" mass="64604" checksum="2C2276ABC1D4E481" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9CIJ8</accession>
    <name>E9CIJ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Krox-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343056.1">
        <property type="nucleotide sequence ID" value="XM_004343006.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270832.1">
        <property type="nucleotide sequence ID" value="XM_011272530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CIJ8"/>
    <dbReference type="STRING" id="595528.E9CIJ8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CIJ8"/>
    <dbReference type="OMA" id="IPCYELT"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="832" mass="92641" checksum="18D273C49E49052F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0D0</accession>
    <name>A0A0D2U0D0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tax interaction protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365136.1">
        <property type="nucleotide sequence ID" value="XM_004365079.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0D0"/>
    <dbReference type="STRING" id="595528.A0A0D2U0D0"/>
    <dbReference type="eggNOG" id="KOG3938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0D0"/>
    <dbReference type="OMA" id="VGWRHYE"/>
    <dbReference type="OrthoDB" id="6509831at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0D0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF1">
        <property type="entry name" value="GH21964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="301" mass="31902" checksum="11DE6828E5560BC3" modified="2015-04-29" version="1">MPIFGKNEGAAAPAAAAKPGQRVEFSFSTQLAHGSATKKISNFSNVKEMYQAISTAFSVPFGDIVFCTLNTPKIDMNRLLGGQIVFDDFIFAHLRGETKVAEVEKTSSTLGLSITDNGAGSAFIKRIYPDSILAKIPQVSVGDLIEEINGVSMLNKRHSDVANTLKEVPVGSKFVLKLAAVKRQGGDEKHATPAAAAAAAAAAPAVKPPAEEKPAAPSTQNFSDANNSAAIATKVEDLLESFMGIRDGDLASEMISLADGLENKEQFIDLVQENLGAFEFPDEFSLDVWDVIHGGEAALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2C6</accession>
    <name>A0A0D2U2C6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365726.1">
        <property type="nucleotide sequence ID" value="XM_004365669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2C6"/>
    <dbReference type="STRING" id="595528.A0A0D2U2C6"/>
    <dbReference type="eggNOG" id="KOG4064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2C6"/>
    <dbReference type="OMA" id="NQVAYMA"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2C6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="24684" checksum="F7081161ACBDE236" modified="2015-04-29" version="1">MDSTLSLEVMIQKLDVLMSQETVSVAAVNKLLESYDASRGDWQRYGQTFDAVRYTRTRVWGNKNYNLLVLAWDQGQGSAIHDHENSVCFMKILDGALTETRFSWAKSTGNEDDQEIRVVGSRTLQRNGVAFITDQIGLHAMNNKSNSDKCVSLHLYSPPFEECGVFGADGQALPRSKLTFCKDHAVKSLVPSSTEIAESVKRGCVFDQAEFEALAAAQAVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2K1</accession>
    <name>A0A0D2U2K1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365766.2">
        <property type="nucleotide sequence ID" value="XM_004365709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2K1"/>
    <dbReference type="STRING" id="595528.A0A0D2U2K1"/>
    <dbReference type="eggNOG" id="ENOG502S22Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2K1"/>
    <dbReference type="OrthoDB" id="15830at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2K1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF46">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="349" mass="39076" checksum="EB5332624090E5D4" modified="2015-04-29" version="1">MLCSRLLPSLLSRSARELSTVPVTRNNPPRCTMAAAMLARYTSAAPEPQSLATNQQSAPAHRRVQLDVPTADMKREFAEQGFLKVPGVISREFCAELNERIDRCFTGRFETGHYPDEWYWRAEMSLPDVTRHMCNIWKSDRLVASMVLSREVARFAAGLMNFDGARIGNDSVWVKPPNGTEITFHTDAFYVPYPMITCWLTLTDVSEANGTLQYIPGSHRWPKTAAIDRDAFHAPTSSYLSPAYEAAHAAGVDASTIKVESVELPAGSIVFHHGDMWHGSCKNTTSERWRRSLGIHLIPHTSRFGQGDGYIYGRYRKAGDDSMDPAFFPILWSKDGQRSATIKSHVGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U539</accession>
    <name>A0A0D2U539_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364478.1">
        <property type="nucleotide sequence ID" value="XM_004364421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U539"/>
    <dbReference type="STRING" id="595528.A0A0D2U539"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U539"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U539"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF5">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="32437" checksum="C2B81C08CFDF8952" modified="2015-04-29" version="1">MEEIARVERCSPTDYYAILAVDQQTWTADSVRRQYIRLSRLVHPDKHGNSPSSTAAFQRVAAAYKAIGTEEGKRAYDAAQAAGTGPTWSNTTTVNAEELLAEVLRQMYKEFCEGELDNIMRMLDQVMALQPDLQLDRQSILTTLERSSKWVQSVQTMSASIKEEFLTFADAYGRFHALAYSDIFGRFDLALLCIRVVIGLPTKTAGTSFAIPERAVSLIISTQNAIDVGRTHIQNFSESWNRASVAEHLQNVALGTIRAIANLRSGRTSASLDSAVESAAAASSSEGDPAPTAPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7V1</accession>
    <name>A0A0D2U7V1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349088.1">
        <property type="nucleotide sequence ID" value="XM_004349038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7V1"/>
    <dbReference type="eggNOG" id="KOG2857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7V1"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="214" mass="22638" checksum="9B76869F0F36BF40" modified="2015-04-29" version="1">MASPPPPALACAVCAVAVSKYKCPQCLAKYCSLPCFKLHKATCGEQQQRLTFETTLPRGPDSATASQVQQPLTTQSETVVDATTSAPLTSGGGAAVHASALPVQHESSSTNQQPLPLHLLLQSSDLRQFAASHPTLQTTLHAILTADNPLQTLISYLNSASDAEASALVDLSKHCMAAIGDHPAVERMRGEQALAEKQQLQREFALDPTGTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U854</accession>
    <name>A0A0D2U854_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_002445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349195.2">
        <property type="nucleotide sequence ID" value="XM_004349145.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U854"/>
    <dbReference type="STRING" id="595528.A0A0D2U854"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U854"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U854"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252430" description="ferroxidase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE91286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="27869" checksum="DF4AF299357D9E59" modified="2015-04-29" version="1">MRIIHWLFCSNLIHPVYLSTAFPPMLRSSFSALVRLRLAVAAAPRSQASLRQALASHAPLSTDARSAGFGLPSSSAAAAVAGHRRSISLAAVSKAAQHPAAPSSSSRLNAAEAAPSTSKTAPSSGEGTASTFMAPKSTRGDESAASALTAHEYHRLADSTLHDVRASLEETIDNAGDEVLDYDIIEQSGVMTMAFGSKGTYVLNKQAPNQQMWLSSPASGPHRFDWSSTQQAWISTQNPKLNLLELLETEFASRIGLRVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U859</accession>
    <name>A0A0D2U859_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U859"/>
    <dbReference type="FunCoup" id="A0A0D2U859">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U859"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U859"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U859"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253242" description="histone acetyltransferase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="792"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="881" mass="95788" checksum="3691E8CE7B3E5212" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8H3</accession>
    <name>A0A0D2U8H3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8H3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1327" mass="145303" checksum="6D2BA24DD6527C04" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9U6</accession>
    <name>A0A0D2U9U6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hgsnat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363755.1">
        <property type="nucleotide sequence ID" value="XM_004363698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9U6"/>
    <dbReference type="STRING" id="595528.A0A0D2U9U6"/>
    <dbReference type="eggNOG" id="KOG4683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9U6"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9U6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="800" mass="86917" checksum="3942C3A78CC1D5E4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAW6</accession>
    <name>A0A0D2UAW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364024.1">
        <property type="nucleotide sequence ID" value="XM_004363967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAW6"/>
    <dbReference type="STRING" id="595528.A0A0D2UAW6"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAW6"/>
    <dbReference type="OMA" id="DISKSHW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF181">
        <property type="entry name" value="LP04042P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253284" description="LRRNT domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="769" mass="79003" checksum="D60E61A83B8F06E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBL9</accession>
    <name>A0A0D2UBL9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364246.1">
        <property type="nucleotide sequence ID" value="XM_004364189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBL9"/>
    <dbReference type="InParanoid" id="A0A0D2UBL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1039" mass="111471" checksum="DD6465ECAE3C171B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCI7</accession>
    <name>A0A0D2UCI7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD-repeat protein GhTTG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363383.1">
        <property type="nucleotide sequence ID" value="XM_004363326.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCI7"/>
    <dbReference type="FunCoup" id="A0A0D2UCI7">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UCI7"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCI7"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCI7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="328" mass="37314" checksum="3936221751ADBB35" modified="2015-04-29" version="1">MSTVESRRKEVYTYKAPWSVYTLNWSNRQRYRLAVGSFLEEYSNQVTIVQLDDDKNDFVCNATFDHSYPATKLMWAPENANCDQDMLATTGDYLRLWRVDDQNKAKLVGILNNNRQSEYCAPLTSFDWNDVDPNIIGTASIDTTCTIWDVQAQAVRTQLIAHDKEVYDIAFAHSKDIFASVGADGSVRMFDLRNLEHSTIMYETAELTPLLRIEWNKKNPNYLATFMMDSSEVIIIDTRFPSVPYAELTAHRGSVNGISWAPHSSCHICTVGDDAQALIWDISQSMRPIEDPILAYFSGAEVDQVQWSTTQPDWIGIGLGNRVQILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCS2</accession>
    <name>A0A0D2UCS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363470.2">
        <property type="nucleotide sequence ID" value="XM_004363413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCS2"/>
    <dbReference type="InParanoid" id="A0A0D2UCS2"/>
    <dbReference type="OrthoDB" id="3270863at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="338" mass="35620" checksum="CD8E69E3DB951F32" modified="2015-04-29" version="1">MLTEAQIDALKRPELQQLAKEHGIRANQKNEVLKQALLELFQSALAAPAAVSLAQTAQEEEQQALQVDAQTEHATVAEEASTSAAEPAQELEESPKIELPQIQNAAELETLLFAEGETVNQAGECANQPIEAAMPVDAETPTAPIAPVDDARSAPDAAAPKEPCSSTNDDSKKNADGETHLVVTTRPSEGLKQNGPPAKTSVPASYVPPKVTRPYTSLAYEMVRRQAQQQRASQMQSASAFAPSTEAHAPKVAPKLPANSRSSSSSLAETKRSAPFSTSLKPAAVKPAASHQSKPAVSSTNPLGLHKTNTLGMHASGPALKEPRTQAATQTRASISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCV4</accession>
    <name>A0A0D2UCV4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCV4"/>
    <dbReference type="InParanoid" id="A0A0D2UCV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="599" mass="63722" checksum="2038082E2479D721" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE18</accession>
    <name>A0A0D2UE18_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347982.1">
        <property type="nucleotide sequence ID" value="XM_004347932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE18"/>
    <dbReference type="eggNOG" id="KOG1908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE18"/>
    <dbReference type="OMA" id="MSEPHER"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="851" mass="86896" checksum="51013395D2DA6767" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFY0</accession>
    <name>A0A0D2UFY0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_004723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347470.1">
        <property type="nucleotide sequence ID" value="XM_004347420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFY0"/>
    <dbReference type="FunCoup" id="A0A0D2UFY0">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UFY0"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFY0"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFY0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="518"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="854"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1185" mass="125914" checksum="62EA2542F7C72556" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGD4</accession>
    <name>A0A0D2UGD4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347547.1">
        <property type="nucleotide sequence ID" value="XM_004347497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGD4"/>
    <dbReference type="eggNOG" id="KOG4310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGD4"/>
    <dbReference type="OMA" id="DWEHEIA"/>
    <dbReference type="OrthoDB" id="47923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGD4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="486" mass="49180" checksum="E79A6C69E52AFEAE" modified="2015-04-29" version="1">MSLWGAWSALTSSLSDASSSSSSTSTTQSSSTTTGAAAGGAAAAGSTKPTTASASASASASASATGAASAPVNASSSSSDTSAGGRGGDIGASAASATLRSSVIVPQQPESDDATSSSAPNAAATTVNNEANPAATAAAAAAATGQARAGDKVSAFGSFAFGNLSSFASSALGNINTVVHKIKENVETTSFIASFEEEQQKFVQEKNRQRQHVGQGVPPWVGYHEEAEMKAQILSLSSDRRNFLTSPPKGAQVVFDFERFAPTALATLREDPELEKMRFELVPKHIAESDFWRNYFYRVSLVKQSSQLTALVHANAGSIHSAASSGSTTPVAPPIAAAIAAPQIAALSESKLSAPATPAAAPQQAAAAAAAAAAAAAGGVATPVSQARKRAPSAAEIYEPPQPSTAEFVSDTLHVVPPAVSPLKLAPVTTPVVASSSSLSASDSPDDNVDWEHEIAEELNDAVLHDSSDLSDAAWEKDIQEALELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ99</accession>
    <name>A0A0D2UJ99_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346314.1">
        <property type="nucleotide sequence ID" value="XM_004346264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ99"/>
    <dbReference type="InParanoid" id="A0A0D2UJ99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="637" mass="65868" checksum="CD405567E89D566F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULB6</accession>
    <name>A0A0D2ULB6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULB6"/>
    <dbReference type="FunCoup" id="A0A0D2ULB6">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2ULB6"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULB6"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULB6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="10">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="9">
        <location>
            <begin position="282"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="550" mass="63258" checksum="B07DD6662D9BD6E5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQH2</accession>
    <name>A0A0D2UQH2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WDR59 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343564.1">
        <property type="nucleotide sequence ID" value="XM_004343514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQH2"/>
    <dbReference type="STRING" id="595528.A0A0D2UQH2"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQH2"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQH2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="486" mass="51914" checksum="6F077D446245E8CB" modified="2015-04-29" version="1">MAGPSSTSGTTGTTTTTSGSNTMRGSPSPVTSPGPLLMSGQTTPQPSLMHPYGHHHHHQQQQQQQQHSAVTTPIAASSSSAAAATAGVLSRGASSNSLTSLGLNPAAANMLDVSSSFSISGAPGAAGLGGTGSGSGSAATTLYPSASFHASSTSLSMLAADAESTTFGTNMVARLDQQPTCFSIDASGTLGVVASRKGLSIIDLEAPDQPARPLVHHTKWEINDVQWNPHTTRSSYIASTSNTKALIWNAADDRTPLLHVLKTHQRAISDINWSNFDENVLATASVDTYIHVWDIRDPSKPSASLCAWTSGALQVKWNRFNRNLLASAHDGDVRIWDLRKGTAPAVYITGHMAKIYGLDWSRSSENELVSCAQDAKAKLWNITNTRAPQAVIHAGAPIWRARFTPFGNGLLTITLPPPQLRVDNSVLLWSLDNVSAPIHSYNGHSEQVKEFDWRIRGSDDYRDFQLVTCSKTRPCAFGISMHTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USR2</accession>
    <name>A0A0D2USR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342656.1">
        <property type="nucleotide sequence ID" value="XM_004342607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USR2"/>
    <dbReference type="InParanoid" id="A0A0D2USR2"/>
    <dbReference type="OMA" id="RSGHYTH"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="3">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="147" mass="15896" checksum="7FA1CF23C21F677B" modified="2015-04-29" version="1">MASTGNSTVWHIVAFKVNPTASAQQVLDMMEGLRGLRSLPGVLQLEVGVHDPRMYEGYVDRSKGYTHALVVELASPEALVNYAKSPEHQAVVVNLLRPVCELDTITAVDYVARKHVKSPIWCHSPHLISVVAAAAALAVGFALGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTI8</accession>
    <name>A0A0D2UTI8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346381">
        <property type="protein sequence ID" value="KJE98301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTI8"/>
    <dbReference type="InParanoid" id="A0A0D2UTI8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="77" mass="8392" checksum="79BBC33A435C34B9" modified="2015-04-29" version="1">MGKNRRAPPALPAAASKRQAEDPSEGQSKRARTEDNDKSETTNDVAPMDTSNATSQQQQQQQPGSTPLRVRDDQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTX8</accession>
    <name>A0A0D2UTX8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346436">
        <property type="protein sequence ID" value="KJE98446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTX8"/>
    <dbReference type="STRING" id="595528.A0A0D2UTX8"/>
    <dbReference type="InParanoid" id="A0A0D2UTX8"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="93" mass="10789" checksum="6F563F69B125E8AE" modified="2015-04-29" version="1">MPDPSIVSPADHLFEFLRELLSTLPACLHCDGEFFPVGRILDSQLRDDDELWYLIRWKDRPASEDSWEPAYNIVPGNARMVNAYHRAHPNKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG01</accession>
    <name>A0A0D2VG01_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365178.1">
        <property type="nucleotide sequence ID" value="XM_004365121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG01"/>
    <dbReference type="FunCoup" id="A0A0D2VG01">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VG01"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG01"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VG01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="269" mass="28263" checksum="A9CA3F1F06024F5B" modified="2015-04-29" version="1">MPRLNGKVAIITGAGGGIGREAAIRFANEGAKVVAADVNDAAGNETVEMINKVHPGAAVYVHSDVSKAADCENMVKVAEEKFSKLNIIFNNAGIMHPKDDDATGTDEAIWDLTMNINLKGVWLGIKYAIPAMRRAGGGSIINTASFVGLLGAATPQVAYTASKGGVLALSREIAVIHARENIRCNSICPGPLRTPLLMDFLNTEEKKERRLVHVPMGRFGEAAEIAQAALFLASDESSYITGSSMTVDGGITAAYVTPTGPTKSLPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI89</accession>
    <name>A0A0D2VI89_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365960.1">
        <property type="nucleotide sequence ID" value="XM_004365903.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI89"/>
    <dbReference type="STRING" id="595528.A0A0D2VI89"/>
    <dbReference type="eggNOG" id="ENOG502QRCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI89"/>
    <dbReference type="OrthoDB" id="20238at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028280">
        <property type="entry name" value="Njmu-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14416:SF2">
        <property type="entry name" value="PROTEIN NJMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15053">
        <property type="entry name" value="Njmu-R1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="726" mass="77357" checksum="FD67993863C55C6D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIG1</accession>
    <name>A0A0D2VIG1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349693.2">
        <property type="nucleotide sequence ID" value="XM_004349643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIG1"/>
    <dbReference type="STRING" id="595528.A0A0D2VIG1"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIG1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIG1"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="79"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="508" mass="54578" checksum="72D21ABFB6BE6F91" modified="2015-04-29" version="1">MPSDASPSLASSSSTAAVVVGVVVTGDRVLLSSAAEPVRAAIVVDVASGTVARIHTDDAAIDAAVQQATQVIEGGSNLILPGVVDCHVHINEPGRTDWEGFDTATRAAAAGGVTTVVDMPLNSIPPTTTVDNLNIKTTAAQPQCWVDVGFWGGVVPGNAPSLQPLLQAGVRGFKCFLINSGVEEFPHVTRMDLDSAMAALQGTGGVLLFHAEVEPCNSVLNGQNSSGTHQHDVTKYDTFLNSRPKAMENEAIELVISLCRQYRVRCHIVHLSSAEALPAIASAKAENLPLTVETCHHYLFHKAESIPDKATHFKCCPPIRDSANRERLWDAVRDGTIDIVVSDHSPCTPNLKLLENGDFMQAWGGISSLQFGLSIMWTEAFNHGLTLRQIVGLMCERTAQLASLAHRKGRIQEGYDADFVIWDDTAELKITTDMIQHKNKVTPYADLTLRGVACKTIVRGQVVYEHAAGTTPFANTKPVGKLLLEPLSRLSEKRIADESSEGDAKRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJL0</accession>
    <name>A0A0D2VJL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364372.1">
        <property type="nucleotide sequence ID" value="XM_004364315.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJL0"/>
    <dbReference type="FunCoup" id="A0A0D2VJL0">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJL0"/>
    <dbReference type="eggNOG" id="KOG4056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJL0"/>
    <dbReference type="OMA" id="PPPIFQI"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15721" checksum="F40D7BD0DD241627" modified="2015-04-29" version="1">MSLSTIVAATTASALVAYLVYFDHQRRNAPDYREKLIARRREERKAARRAAHAPVPDMNDREALQAYFVEQMRLGEDTLTAGNFGQCVKHFANAIRVCQQPTQMLQVFQQSLPPAVFRNLILELDPSYGQQSAPADQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJP7</accession>
    <name>A0A0D2VJP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364426.2">
        <property type="nucleotide sequence ID" value="XM_004364369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJP7"/>
    <dbReference type="STRING" id="595528.A0A0D2VJP7"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJP7"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJP7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF17">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="454"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="642" mass="70411" checksum="52E8D87C1277EDA1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJX6</accession>
    <name>A0A0D2VJX6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364510.1">
        <property type="nucleotide sequence ID" value="XM_004364453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJX6"/>
    <dbReference type="STRING" id="595528.A0A0D2VJX6"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJX6"/>
    <dbReference type="OMA" id="RCIHRIN"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="780"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="935"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1165" mass="121983" checksum="9B992F935B822CD8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLB4</accession>
    <name>A0A0D2VLB4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLB4"/>
    <dbReference type="InParanoid" id="A0A0D2VLB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="102" mass="11492" checksum="BD87E781FE9D8AD0" modified="2015-04-29" version="1">MAAVVQARTSLEREAGLVRLAIVVDQALSHASASSQHSQPIQQQQQQQQQQQQQQQQPHCLPVIMSHGIFLDRRIFHHQVPPLTAAGHTCIRYDHRGQASHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLT7</accession>
    <name>A0A0D2VLT7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic rRNA processing</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349019.1">
        <property type="nucleotide sequence ID" value="XM_004348969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLT7"/>
    <dbReference type="FunCoup" id="A0A0D2VLT7">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLT7"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLT7"/>
    <dbReference type="OMA" id="RETMFHR"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLT7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38469" checksum="7A28D35536D663C6" modified="2015-04-29" version="1">MLSRAPARKPAAAASQRKPVAATSAAARRAAAAAAAAAQNSNVDSDDESTDESDEDDDLEDGVIHEEEELAQAFKAGLLRADAAVPQRPKINNEERLRERLGDIAQQVDASFPWAERLDLVSTVPIVLDDAQDDFKREMSFYNQALEAVKLARPRLAAANIKFTRPDDYFAEMVKTDDHMRKVREALLSEHQAVERSEQAKKSRQMKQFGKKVQQQVLEDRQKQKTSDLEAIKKFKKDRSAKPDFLDDGDDQFNIGVDKEESHSQKTNSKRSYKNDKYGNGGKKRGSKRNTRDSASDDSSFNFARNKALPKGFKSAGVAKKFGGGAGGKSKAPRPGKSRRRSAKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN33</accession>
    <name>A0A0D2VN33_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">CAOG_002732</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="37">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN33"/>
    <dbReference type="STRING" id="595528.A0A0D2VN33"/>
    <dbReference type="eggNOG" id="KOG3670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN33"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN33"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050253">
        <property type="term" value="F:retinyl-palmitate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KJE91617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="463" mass="50344" checksum="2F1FCCB53DBCDD69" modified="2015-04-29" version="1">MVCCFFNVTSFFVLFYSLVGTSMQRAILLALIVAAVAVSTASAAALPMLTAEQLQLFTAPFFSTRKPTGGLDMPCDTAGGVSETVPTSVHMLRPGDIKVVAALGDSLTAAYAAMDPSIDGMLYEYRNISWSVGGGGSLAEQITLPNILKEYNPDVTGFSTSVNTLFQIPPTAGLNVAVSGAIATGLPAQARSLVNKTKSDPTIDWEKDWKVVTLFIGGNDACALCLNETLHSPQFIRDNIEAALDILLEGLPRTLVNLVELLDVTQLFEVHDDMCDALHQQLCPCLGGVNDTTIRANISATIVEYQRAVAELAQLPKYNSHENFTVVDQPFFSKTKIPLLADNVTPDRSYFAVDCFHFASIAHEASGLALWNSMVEPVGHKRTDWKIGEPLECPSDAHNRPFFFTNYNSYLYLKYGSQFGPGSDSDDHAVAIGVGVSVGVVALLVVIVLFVRWYNRRHSYQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRB5</accession>
    <name>A0A0D2VRB5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAMK/CAMKL/AMPK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348010.2">
        <property type="nucleotide sequence ID" value="XM_004347960.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRB5"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRB5"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1745"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="840"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1754"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1831" mass="190964" checksum="591F208CFFC4CC9A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRW9</accession>
    <name>A0A0D2VRW9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sestrin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348274.1">
        <property type="nucleotide sequence ID" value="XM_004348224.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRW9"/>
    <dbReference type="STRING" id="595528.A0A0D2VRW9"/>
    <dbReference type="eggNOG" id="KOG3746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRW9"/>
    <dbReference type="OMA" id="CSYLINI"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="723" mass="80339" checksum="02008609124B58EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS06</accession>
    <name>A0A0D2VS06_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270430.1">
        <property type="nucleotide sequence ID" value="XM_011272128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS06"/>
    <dbReference type="STRING" id="595528.A0A0D2VS06"/>
    <dbReference type="InParanoid" id="A0A0D2VS06"/>
    <dbReference type="OrthoDB" id="2411356at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46078" checksum="66EB5ED093E9CAC4" modified="2015-04-29" version="1">MSAAPAAAPAAAPDQQQPTFRGVFGFIGGAVANAVSTTFIVLVVAAFVAQHVLDAKKTIMDAKTHSPEVVLARMLARFEAGSVIPRFEKYHVSRPDAVAMLQGVLRPSLLKDYTVVIGEVGCGKTTAVHDAIRANSTGIVYHIVKSEVLVSMPGLLARSLAFEPNQFTFTEGYLKDRGVELDEVTSAAEPFKSWVLLSLILRDVAQQFKTKHGHPATLVIDAVDEIAQQGPALLHAIQDFAKAAADEQLLNVVLVTCDGSNLPELKASSAMTRARIAEVSDITDEQAVDFLLHRGVNEDAAKRAVAEIAGGRFVLLNRLTKQLGRGQQVNQIFEEFREDTADSLQRLIDDLALYNATSAVHKSLCDLTHGALHIDIVHRALGKDLTKKLLATHINILAYHPNDTYTLHSRHVQRSVAALLNCTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS11</accession>
    <name>A0A0D2VS11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal leader peptide-processing protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS11"/>
    <dbReference type="STRING" id="595528.A0A0D2VS11"/>
    <dbReference type="eggNOG" id="KOG1320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS11"/>
    <dbReference type="OrthoDB" id="17845at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039245">
        <property type="entry name" value="TYSND1/DEG15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004:SF0">
        <property type="entry name" value="PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="85984" checksum="323F168245DEC036" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV64</accession>
    <name>A0A0D2VV64_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV64"/>
    <dbReference type="FunCoup" id="A0A0D2VV64">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VV64"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV64"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV64"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="274"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="853" mass="93321" checksum="614544B2BD72C71F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYC2</accession>
    <name>A0A0D2VYC2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343708.1">
        <property type="nucleotide sequence ID" value="XM_004343658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYC2"/>
    <dbReference type="STRING" id="595528.A0A0D2VYC2"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYC2"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="88"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="826"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1042" mass="110573" checksum="EEB0CFD48702AC02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0F3</accession>
    <name>A0A0D2W0F3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0F3"/>
    <dbReference type="InParanoid" id="A0A0D2W0F3"/>
    <dbReference type="OrthoDB" id="10581601at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15369" checksum="6AE095675B79E2AB" modified="2015-04-29" version="1">MASPASSSSSAAPAPEAVPPQQKDQQQRSSLSSLTGLSLSETMLYASFGITGVVMAGQLVYAYRRRRIAEQTLTRAVELYNRRATELAVAHARQAEAGHTADAAGDFAQFPSVQLPDQHSAPSPIASNVSTGSVSSSSSSSSSEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0H7</accession>
    <name>A0A0D2W0H7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342879.1">
        <property type="nucleotide sequence ID" value="XM_004342830.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0H7"/>
    <dbReference type="OMA" id="WEMDDNL"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1745"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1947"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2057"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1610"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1880"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2006"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1745"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1770"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1783"/>
            <end position="1800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2199" mass="239801" checksum="44328A92F13AAE0B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0P8</accession>
    <name>A0A0D2W0P8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270844.1">
        <property type="nucleotide sequence ID" value="XM_011272542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0P8"/>
    <dbReference type="FunCoup" id="A0A0D2W0P8">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0P8"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0P8"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0P8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="144"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="350" mass="39907" checksum="05C948EBB3D73088" modified="2015-04-29" version="1">MPKSSAGLSTPAAAAAKAGKSFKKTAPEPLPSTDAATDASASASVDNPFAARQQMLADMKCKTLKKDLYKQLKHDKSVARRKERDQKLAERRQLGDAAPPKEVPKTIESTREFDETIVNPDDQEVVEDEAMDEFANYFNGETLPKLLITTSIKPVGETFKFVQDLVTAIPNATYVPRQKFDLKQIIEFAKNREFTDVMLINENNKEADGLIITHLPDGPTAHFKLSSIQIAKTIRNHARSSDHRPELVLNNFNTRLGHTVGRMFATLFPHDPEFVGRRVITFHNQRDFIFFRHHRYIFRNAQKVGLQEIGPRFTLKLRSLQKGTFDAKYGEYEWTHKRGEMDTSRRRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1I4</accession>
    <name>A0A0D2W1I4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342771.1">
        <property type="nucleotide sequence ID" value="XM_004342722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1I4"/>
    <dbReference type="FunCoup" id="A0A0D2W1I4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W1I4"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1I4"/>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE98162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="156" mass="18244" checksum="FABC684ED28BE0E7" modified="2015-04-29" version="1">MSTARVAMNRQGVEDAYAEPMNFLEIDVLDPQTHGLGRARYTDYEIRLRTNLPVFKVQEAVVRRRYSDFEWLKNELERDSKILVPALPGKAIMKQLPLLTKDEGIFEDAFIEERRKGLEVFINKIAGHPLAQNERCLHMFLVDRRIDRNYTPGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1N9</accession>
    <name>A0A0D2W1N9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270904.1">
        <property type="nucleotide sequence ID" value="XM_011272602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1N9"/>
    <dbReference type="STRING" id="595528.A0A0D2W1N9"/>
    <dbReference type="InParanoid" id="A0A0D2W1N9"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1N9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266199" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29351" checksum="B6F2695DA791D063" modified="2015-04-29" version="1" fragment="single">MSKRATFGLVLLLGVILNHAQLTQAVNACGSGGVCTCTGTGVSCISKYLTAIPSEIPVDTTKLTLSFNQITSISANAFAGLTALTDLQLNNNNITIIPDYTFANLPALTELHLFFNPITSISANSFAGLTVLNLLNSYNCQITSIAANAFTDLSKLTNMQMSGNQITSIAPNVFSGMSALKILYLNGNQITSISASAFTGLTALTYLSLDSNQISSIALNAFPGMSALKILRLNINQITGISAGVFTDLSALKELWLNDNQITSISANAFTGLTALTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGT6</accession>
    <name>A0A0D2WGT6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Purinergic receptor P2X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P2X receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGT6"/>
    <dbReference type="STRING" id="595528.A0A0D2WGT6"/>
    <dbReference type="eggNOG" id="ENOG502QSUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGT6"/>
    <dbReference type="OrthoDB" id="494673at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGT6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00863">
        <property type="entry name" value="P2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF31">
        <property type="entry name" value="P2X RECEPTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01307">
        <property type="entry name" value="P2XRECEPTOR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="474" mass="51843" checksum="115A5EA2B7263334" modified="2015-04-29" version="1">MSESKPTLRSRVATTLGEGFRAVVAYETAKVVEVRSLKLGFFNRFVQLAILGYVIGYTIVYQKGYQTQAPLQSTLTTKVKNVGFACQSTDSAGGRYGGRGGAAIGVTTCPIPGVDPPGNTELSLWDSTDYVIPANEHDALFILTNSIVTPEQKQTTCAEDPQYAQACTDDSECTKYSSTRNGKRIMTGRCVNSTCEIYAWAPLELDSLSPQSGSVIEQAGNFTVFIKNNVRFAKFGISRTNVDIGNTSAAYLANCRWNKETDYYCPIFKLGDLVEASGWKIEDMLVLGGVLGVNLDWTCNFDNDESECRPVFSISRIDDPTSTSPGYNFRYADYYTLPSPTDPSISVPHRDLIKAYGIRLIFVVSGEGGKFDVAALTMSLGSGLALLGLATLLCDFFMTHFFAKKDYYREKKFELVDDLPPLDQTFSRLVGGPRRSEVAVPVPSTSTSVGSVQGGNTASEKSPLLQEDQRHTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHX5</accession>
    <name>A0A0D2WHX5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365686.2">
        <property type="nucleotide sequence ID" value="XM_004365629.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WHX5">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHX5"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHX5"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="747"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1363" mass="148075" checksum="0D88206F308ED3FF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI06</accession>
    <name>A0A0D2WI06_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Origin recognition complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI06"/>
    <dbReference type="STRING" id="595528.A0A0D2WI06"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI06"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="6">
        <location>
            <begin position="523"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="7">
        <location>
            <begin position="749"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="821" mass="90523" checksum="DBBFA7528463081F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI57</accession>
    <name>A0A0D2WI57_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365082.1">
        <property type="nucleotide sequence ID" value="XM_004365025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI57"/>
    <dbReference type="STRING" id="595528.A0A0D2WI57"/>
    <dbReference type="eggNOG" id="KOG2856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI57"/>
    <dbReference type="OMA" id="ACQMKEL"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI57"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="347"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46115" checksum="335547B7A0233823" modified="2015-04-29" version="1">MGDESFWEVEQYKRVVERVSNAPKLCDELVACVDERENLEKAYAKSLQSWAKKWEGQIASEKSMEFGTLKTGWGGLFTEAYGKAEAHLAIIRDLQSAVNSAVDKWKSENFHKSIIHFKETKLAEDGFEKAQKPWIKHKHKVDKYRKLYHSAAKTAHVLQKRATEAEGNNQCSAEECSKMAEKASKAAQEADVLRQKYEEYLRIITEYRPNYIRDMKEVFERWQEFEGLRIEFFKRTLLDYQRIVDVSNNAGISATSTALNSILNGIDSNEDLHSFSQLKGADMDYHWPEFEEWTPNTPDDLDVPPSQVTRQNSHSSQMSASPTTTRASPQARTLPPAAGTFDEDWGDSSVKVRALYDYVASDREEISFSEGDTITQLEGEDDQGWCRGTVNGRTGLYPASYVQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIE5</accession>
    <name>A0A0D2WIE5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIE5"/>
    <dbReference type="FunCoup" id="A0A0D2WIE5">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIE5"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIE5"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIE5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="206"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="812" mass="87148" checksum="678747D32099EA84" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJE2</accession>
    <name>A0A0D2WJE2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJE2"/>
    <dbReference type="STRING" id="595528.A0A0D2WJE2"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJE2"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="362" mass="39164" checksum="428E0F2752918A52" modified="2015-04-29" version="1">MASRLAEYLDKNTLKDKLSITYAAAGEDTRQFKVTFDGVTMDATLVDLPTIIESQKSVDKRNFYKTADICQMLVCTSEDPEKKNVQVIYPHGLSAPLKNVRKKRFRKSAASKLTNSWEVQTAVARLLRDNMLASSDTYELVDVTEETAPAGDEDVELVSDDEAEANAVGSDSEEEEEESDDEDVEDREEEDVEADKEIMEDEASECGFKDNTASSSGQRIDVDEEGAGDQDSSSDSDSDSSSSDSSSSSDDESSTQVASSTQSTASAPAPPSSSSSAPQPMQIEVTETPEQAAERQSRAAAIEAATAEVTRLETRVAEVRKQLAATNNPLLSARVRASLRQAEEELNSKTQALESLKAASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKB3</accession>
    <name>A0A0D2WKB3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease GOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364795.2">
        <property type="nucleotide sequence ID" value="XM_004364738.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKB3"/>
    <dbReference type="FunCoup" id="A0A0D2WKB3">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKB3"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKB3"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="364"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="60446" checksum="5AA36683227F061C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL90</accession>
    <name>A0A0D2WL90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270133.1">
        <property type="nucleotide sequence ID" value="XM_011271831.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL90"/>
    <dbReference type="eggNOG" id="KOG3686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL90"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL90"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="79"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="196"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="916"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="6">
        <location>
            <begin position="1675"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="8">
        <location>
            <begin position="2060"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1250"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1509"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2011"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1509"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2018"/>
            <end position="2036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2385" mass="255310" checksum="C3C066B7827D620D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLP7</accession>
    <name>A0A0D2WLP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270181.1">
        <property type="nucleotide sequence ID" value="XM_011271879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLP7"/>
    <dbReference type="InParanoid" id="A0A0D2WLP7"/>
    <dbReference type="OrthoDB" id="17570at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLP7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25766" checksum="5EDE7F6CFAE30FA5" modified="2015-04-29" version="1" fragment="single">MGVAAAVAVAEGDANIMSSTTLHQEHSMIHHNAGDDDDDDDDPTNADPYADWGVDRCLTLVLALLYMALFLTVISQLARIVYYRHRLGSFQVGFQSLCLVWTLLRSIWFAKALATRWSNLVEELIYWPPVNLEFATFSLLGVFFVRIIHQQAWRDIHRRVMAAWVALNLFLLFLNVLWIAYIGDASTVSEDLVEVREAFVASTFLILAVIIGYFSWRLIVVLNSSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WME4</accession>
    <name>A0A0D2WME4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WME4"/>
    <dbReference type="STRING" id="595528.A0A0D2WME4"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WME4"/>
    <dbReference type="PhylomeDB" id="A0A0D2WME4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="474" mass="48602" checksum="9207E7066DB7B093" modified="2015-04-29" version="1">MLLWLDGRVNLDSSNAPISTLQLYYSTPVVLSANTFTNFNSLTYLSLRDASSMEDHALAGLPSLFELVLTGSLTSVAAAVQGVSPLEDVSSSLQMLTIAESNVASISDVGFNSLTKLKQLVIQTSRITSISSNAFAALTSLTSLTLNSNPITSIHADAFAGITRLQALSLQNTPLTTLPPGLLYGLSSLNVANFVSNNFSFGGNTVPPPSTFGNVGNPQTFMASASSDSASVASITSVSYMKIANSVASAVSVSTNSIASAESVASVKSAASVSVSSASIQSSISAKSAVSARSIASIKSVTTAQPVTSAATDISAGSGSVASATSSLSTMSVSATRNVAASNAPTGDDESLSVLPIIVGALGGVLLLALIAIGILIRRHRASRPTNQPASQDLHVKLNNPVYDQKPSTDSLWYSGVVTPSSNDASTGSVYETIPPVDKTYAELSLASGTSTRPFTRVDVVYAEPLVTPTNTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMH5</accession>
    <name>A0A0D2WMH5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMH5"/>
    <dbReference type="InParanoid" id="A0A0D2WMH5"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="41273" checksum="F7D34E0A26EEB624" modified="2015-04-29" version="1">MLAAATKTTKTTKTTKAETEVKAKTKTKTKETDPDTVQAKAPTKASSRSRVSTTKSEATPSPAVTGTDGDGAHVQSGASQASQAAAAAASTLPPGKAPPFNPLATLMFDSRQRALARKHPLDTIRSPLVAEMLVNMLGDVRGKTFVDVNCGVGLVSRLLLNKGAAHVLGTNQSSGVMGHYMELAERSNHRFALWQTSWPRDLDTPILPERLWNAPKRSWDEEPSVEVVGGGGRWAPVKLLEDLIARRGIFHFGRIPFTVLANVRKFACTLTAARPDGTVAPVTDSTIVGSHSYIDITYMLLFEATSIIYPVAEFHTSFGASSLLYSGSWTNKRKTIGVAAHCFVFFFLFFFSVFVATPAYAPASTRMPHSARSEIHQLATHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMN2</accession>
    <name>A0A0D2WMN2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidylserine receptor long form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMN2"/>
    <dbReference type="STRING" id="595528.A0A0D2WMN2"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMN2"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000045">
        <property type="entry name" value="F-box protein At1g78280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUMONJI, JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="295"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122627" checksum="F8D7644BDB59C807" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN20</accession>
    <name>A0A0D2WN20_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364241.1">
        <property type="nucleotide sequence ID" value="XM_004364184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN20"/>
    <dbReference type="STRING" id="595528.A0A0D2WN20"/>
    <dbReference type="eggNOG" id="KOG3521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN20"/>
    <dbReference type="OMA" id="EHCRIED"/>
    <dbReference type="OrthoDB" id="5585231at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="315"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="557"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="73870" checksum="39E0B1F5913D42EE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN26</accession>
    <name>A0A0D2WN26_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364250.2">
        <property type="nucleotide sequence ID" value="XM_004364193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN26"/>
    <dbReference type="STRING" id="595528.A0A0D2WN26"/>
    <dbReference type="eggNOG" id="ENOG502S6WF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN26"/>
    <dbReference type="OrthoDB" id="2133451at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN26"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="642" mass="69884" checksum="36A07826C3AD3A29" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN54</accession>
    <name>A0A0D2WN54_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270250.1">
        <property type="nucleotide sequence ID" value="XM_011271948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN54"/>
    <dbReference type="STRING" id="595528.A0A0D2WN54"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN54"/>
    <dbReference type="OMA" id="WIGPNCK"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN54"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="145" mass="16018" checksum="4C806C2E647D8EE9" modified="2015-04-29" version="1">MATKDAKLDRDEVTNAYNAVRDNNDPITWAVFKYGDGNLISTAATGTEYDEFLTHFTDDERVYGFLRLETGDELSKRAKFAFVAWIGEDVGALKKAKVSTDKAIVKSVVASFAAEILTSERSDLRYDTIFARVKKAGGADYNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPS8</accession>
    <name>A0A0D2WPS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPS8"/>
    <dbReference type="FunCoup" id="A0A0D2WPS8">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPS8"/>
    <dbReference type="eggNOG" id="KOG0542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPS8"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="48"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="269" mass="29596" checksum="8052D652F94B70E7" modified="2015-04-29" version="1">MVDCHCARVVFTAFERASQSTQCTHFHNGTDATILTSTAELEPQSFRYLLVLDFEAVCDEVTRPKPQEIIEFPTVVLDTTTLEIVGSFHKYVRPVSHPILTPFCTTLTGITQDMVSGQATFQEVFDEHLAWIQSFWKSLPPAANADADAASTASSSIPSEAPTWAFVTCGDWDLNRALPDQLAALGKKSPAPYRQWINIKKEFAVKYGVSPPGMTAMLDMLRLDLVGRHHSGIDDCRNIAAVAKEMLRDGHVFEITGTRGESKGSKASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPT6</accession>
    <name>A0A0D2WPT6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363404.1">
        <property type="nucleotide sequence ID" value="XM_004363347.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0D2WPT6"/>
    <dbReference type="STRING" id="595528.A0A0D2WPT6"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPT6"/>
    <dbReference type="OMA" id="FITYQSS"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPT6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000016">
        <property type="entry name" value="Insulin-like growth factor 2 receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266492" description="MRH domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="2933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2860"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="178"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="336"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="483"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="640"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="787"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="937"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1379"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1531"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1823"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1967"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="2120"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="2263"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="2414"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="2554"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="2696"/>
            <end position="2838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2933" mass="310956" checksum="33C39053B4D84A0D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPU5</accession>
    <name>A0A0D2WPU5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPU5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPU5"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPU5"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="897"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139551" checksum="9C19CC562D552968" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ36</accession>
    <name>A0A0D2WQ36_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine and histidine-rich domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363584.2">
        <property type="nucleotide sequence ID" value="XM_004363527.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ36"/>
    <dbReference type="STRING" id="595528.A0A0D2WQ36"/>
    <dbReference type="InParanoid" id="A0A0D2WQ36"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ36"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="237"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="34949" checksum="C0CA285180C7E877" modified="2015-04-29" version="1">MAKVLCYNKGCGKDFDPSSSSDEATCLFHDGTPVFHEGLKYWSCCPNKRHSDFGEFLNAPGCTRGKHTNVKPAAPAGQPAAAAAQTTPKAQIVVPTPTPPPVSAPEPWVKSTQPLERLKLVVTDAVRAAGAPAAAAAPSANVAAAGANGESAAVQGSAESKVAVGTICVNNACGKSYTGVESLTEPCLHHTGSPVFHEGSKFWSCCKKRTQDFDEFLAQKGCTTATHCWVKSKVAQQVKCRYDWFAMGGSISLNVYAKKVDCDVSYAEANATTLKVHIIFDSVNEFDLEIDLAGKINPAGSEMQVLGSKVEIRLQKADGNAWQSLERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQS5</accession>
    <name>A0A0D2WQS5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348017.1">
        <property type="nucleotide sequence ID" value="XM_004347967.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQS5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQS5"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQS5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQS5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000023">
        <property type="entry name" value="70 kDa heat shock cognate protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="632" mass="69425" checksum="E53159DBD6F70E9D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQU8</accession>
    <name>A0A0D2WQU8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347540.1">
        <property type="nucleotide sequence ID" value="XM_004347490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQU8"/>
    <dbReference type="STRING" id="595528.A0A0D2WQU8"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQU8"/>
    <dbReference type="OMA" id="MIALDSM"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQU8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="44"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="433" mass="46904" checksum="032C7651F64D0C45" modified="2015-04-29" version="1">MTSAASDFVSTASSSAATAQNILFDVRPGEVSFSFGAPDESLLRQIVPVLKQATIERLEADPDAYTLLQYGPIAGDAVFINQLAAFLRLHYNDPHVDATHLMATAGASQGLSFACTHLMKPGDPVLIEDPTYFLAEQLILEHHLKTVGVRTDDDGINVEDLEKQLKAIPIKNPSEGYSAMLYLVPTFSNPRGTTISHEKRQRIVALAHQYNVIVVCDDVYELLCYKGAQPPVPRLFSYDAAILRDTPAASKRGHVISNASFSKIFGPGVRLGWIEAWVDIQEKLTNTGFMASGGGVQHCMSGLMGTAIQNGSLDRVIAALQAAYGARMAAVCAKLRQAIPAGVVNLIEPQGGLFMWVEFRDTAVDTEALLARARREFAVGFQPGNRFSQSKTFGHCMRLGIAFHPEAELLSGVDRLARLIHASIADGSIRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQX6</accession>
    <name>A0A0D2WQX6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347608.1">
        <property type="nucleotide sequence ID" value="XM_004347558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQX6"/>
    <dbReference type="STRING" id="595528.A0A0D2WQX6"/>
    <dbReference type="InParanoid" id="A0A0D2WQX6"/>
    <dbReference type="OMA" id="HAFVGEM"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186:SF2">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186">
        <property type="entry name" value="SIKE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="229" mass="25793" checksum="3EA68BF1FB3828AA" modified="2015-04-29" version="1">MGVDTTKGRGLTEATAEAERLNRALAAADHAIVSLIQRAEAAKDRLSAPNRRQIRAARSELNTAVGRKSIDEVVDTVEKSLAGTTPSLQLAERERDQWLIHLQTENHELREAFDEFQCSLDLIMTKNRENLTTLRSTLKLEQEGVQRRLDRETQENEQLRNENVRLRLKLEEMRKIISLAIESEEQESMETQARIVELETENDGLRELLSVAVQSGSVPASAVAQPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS07</accession>
    <name>A0A0D2WS07_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MLF1-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346106.1">
        <property type="nucleotide sequence ID" value="XM_004346056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS07"/>
    <dbReference type="InParanoid" id="A0A0D2WS07"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50066" checksum="14C40B59AD989071" modified="2015-04-29" version="1">MDDDMPRRLQPEAIARRRALGTRQTTLRSNTITAPLPRAPPRPSPVPAIQHSQAMLRQARQSPIPAHLQPSPRSSGTGGVPSSGSSPAASAAAASSPLRSSSQTSANSAAHSRTPAATSSVGASASHSHAASVKSKQPSTHTPAVRRSQVESDDGGDDNDEDLPPALPPRTQGSSTFAKPLPVVKRPRLESPATGDPDQPSTSKPTQHSVSATASRSSRTEDTAASRQSAKSAPTTKGQKRPAPSDEDVASGESEDEPEDAPRRRQTASSQHSQRRSHSRVDAESADEDWNEPHKDTSQSGKLGYTTVHADRYLIYLRSPNETERSQASITYLDVSLHEIDKLLQHAINTYDRSSTQGLTAKAAIARFRDEFRSIMTDQIAVTEQCGQVRSLVRDGNISRNKRREQMLNLTSLRNEQEGLLADLKGRMEAESKRRDALDVSNILLRRLAEARSNLADHRTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS49</accession>
    <name>A0A0D2WS49_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270476.1">
        <property type="nucleotide sequence ID" value="XM_011272174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS49"/>
    <dbReference type="InParanoid" id="A0A0D2WS49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="40249" checksum="3BBE2590BE6473E2" modified="2015-04-29" version="1">MDAAEAARERRRQRIMANAGNRLQALAETSRATSTEAQHSHADGATTSTATATATATATAQQGEEYERPRGQVVATETATSAEPSAANANADATADAGLIKETPQAHSHAHHGGSVVAASETTAATATTKPESNQADEVTPTTSSTTETSKQEKQDSPAEQRERAASQASHHETDAKLVHRRSPATTTAATAAPVAPPAQERPAAGPHTPKQQVAPAQQATPKQPTPLQPKSAAAWGWPAYRLLLAALLGLLLAGEALRALLADPEIKGTEFVVLHRVLSEGYDYPLLHGMSIIVAFAVMEATFAVFEGNLLPLLMSVFTPSPFGGSPIMRLLPIGSALLSILKNATRDFAAFFFLFATTLAFPLLFVAQEVKDELLDETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSQ8</accession>
    <name>A0A0D2WSQ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSQ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WSQ8"/>
    <dbReference type="InParanoid" id="A0A0D2WSQ8"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSQ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="696" mass="74850" checksum="15BC7B6B032158E1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSU9</accession>
    <name>A0A0D2WSU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSU9"/>
    <dbReference type="STRING" id="595528.A0A0D2WSU9"/>
    <dbReference type="InParanoid" id="A0A0D2WSU9"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="873" mass="88539" checksum="5EAF0FC0F7801712" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT19</accession>
    <name>A0A0D2WT19_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346981.1">
        <property type="nucleotide sequence ID" value="XM_004346931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT19"/>
    <dbReference type="STRING" id="595528.A0A0D2WT19"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT19"/>
    <dbReference type="OMA" id="HIVPMEY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011230">
        <property type="entry name" value="PAP14/16/28/29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030250">
        <property type="entry name" value="Ptase_At2g46880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254768" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="353" mass="38593" checksum="2D41ECB93DD80505" modified="2015-04-29" version="1">MLGERRRLRAVLLAQLLAVVVMLATLAPLAHAGGLTTGAKPPLRFHADGSFKICQFADLHFGEGEDVTWGPVQDTNSSRVMRNVLERERPDLVVFSGDQITGNNVADNATAYWAQVVRECQVMGIPWAIIFGNHDDLASGVNGSRAALMEFDTSFELSYSQFGPEGLPGTSNYYLPLLASDSDQVASWIFFLDSGGGSIDEVITLPQVAWYRNTSASLEALVGRVLPSMAFFHIPLVQYDAVYSPEKCIGMNDDGITPQDEDLGIFQAFLDRGDVQLTSVGHDHGESFCCPLQTLTLCFGRHSGYGGYGDWDRGGRIFILSEPSKTTTQLSFSTYVRMENGTITDGPNFPKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT48</accession>
    <name>A0A0D2WT48_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345562.1">
        <property type="nucleotide sequence ID" value="XM_004345512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT48"/>
    <dbReference type="STRING" id="595528.A0A0D2WT48"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT48"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="743" mass="79792" checksum="840B880F46E84A55" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT49</accession>
    <name>A0A0D2WT49_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT49"/>
    <dbReference type="InParanoid" id="A0A0D2WT49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="138" mass="14109" checksum="E7475C28064D3DAB" modified="2015-04-29" version="1">MSTWSSLSMAIRLRSASTAAAVTEPWATSSGAPSISAASCARSVVMDGSAPFVHPSAAADRAAALVASANDTPSLPLKLLRLPVLSVPPDDRRILRARRRVPSAWDAASASKLLAGSVSSVSTDSLELPAKDASLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT99</accession>
    <name>A0A0D2WT99_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346097.2">
        <property type="nucleotide sequence ID" value="XM_004346047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT99"/>
    <dbReference type="FunCoup" id="A0A0D2WT99">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WT99"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT99"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="576" mass="62269" checksum="05F3FA96614EC257" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTN5</accession>
    <name>A0A0D2WTN5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345043.2">
        <property type="nucleotide sequence ID" value="XM_004344993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTN5"/>
    <dbReference type="STRING" id="595528.A0A0D2WTN5"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTN5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTN5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="268"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="536" mass="59882" checksum="58348A422D104B30" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUM1</accession>
    <name>A0A0D2WUM1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUM1"/>
    <dbReference type="STRING" id="595528.A0A0D2WUM1"/>
    <dbReference type="InParanoid" id="A0A0D2WUM1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="304" mass="32311" checksum="BE80CCEE1E9148E0" modified="2015-04-29" version="1">MFALNALRTAIRVQSALSPSAAAIRALSTATAASAGSSAAVPDVSKLSFNTLLVSKPTANVGLVTLNRPKALNALCDDLMSELNTALEHFHADPTVGAIVITGSERAFAAGADIKEMQPLTYSKCVNTNFLAHWTRVAESRKPILAAVNGFALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTQAVGKSKAMEIVLTGDKYSAQEMERAGLVARVYPVETLVEEVVKKASKIASLSKPVVQLCKEAVNASYEMTLKEGTHFERRLFHSTFGLKDRAEGMTAFVEKRGAKFTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVM3</accession>
    <name>A0A0D2WVM3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343882.1">
        <property type="nucleotide sequence ID" value="XM_004343832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVM3"/>
    <dbReference type="STRING" id="595528.A0A0D2WVM3"/>
    <dbReference type="InParanoid" id="A0A0D2WVM3"/>
    <dbReference type="OrthoDB" id="37484at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1248" mass="134198" checksum="A004438C1A7EEBCD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVW5</accession>
    <name>A0A0D2WVW5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVW5"/>
    <dbReference type="InParanoid" id="A0A0D2WVW5"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="156" mass="16285" checksum="FC1929554A98B2C1" modified="2015-04-29" version="1">MRRFTGGRSMKMSIERSSMLSVIAQLASQSLFCSLSRKATSHFSTDCSNNQTADRMGINCPACSGPVASGQKEAMGKTWHPKCFVCKKCGKQLANEYKVVSNKAYCNVCVDRTPALLKASRGSSSSAGGQPRQSNASTSSGNRGGSNGGGGGCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW53</accession>
    <name>A0A0D2WW53_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343667.2">
        <property type="nucleotide sequence ID" value="XM_004343617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW53"/>
    <dbReference type="STRING" id="595528.A0A0D2WW53"/>
    <dbReference type="eggNOG" id="KOG0965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW53"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="600"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="681" mass="73670" checksum="5DD39BF83D792D46" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW55</accession>
    <name>A0A0D2WW55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270712.1">
        <property type="nucleotide sequence ID" value="XM_011272410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW55"/>
    <dbReference type="STRING" id="595528.A0A0D2WW55"/>
    <dbReference type="eggNOG" id="KOG4579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW55"/>
    <dbReference type="OMA" id="CLDANTI"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="192" mass="20654" checksum="B5EB4CE9D2271300" modified="2015-04-29" version="1">MAAEAARVALRCNDAWSTGQLDLSACQLTSLPLGVFTLVREVKVTSVDLSDNIMSKLTPKIAQLAHVQVLSLARNKLTSLPDEMGALSELRSLNLAGNKLTQLPDVISTLTGLESLDLSGNDIVSIDVPTVLGPLKSLNVLNINGNCLDANTISSLWQLRCNTTIDDNRTPPQPGDLPITHTTTRHTQLSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXU0</accession>
    <name>A0A0D2WXU0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXU0"/>
    <dbReference type="STRING" id="595528.A0A0D2WXU0"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXU0"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXU0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF262">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="91605" checksum="543451B98842E511" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0N6</accession>
    <name>A0A0D2X0N6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365728.1">
        <property type="nucleotide sequence ID" value="XM_004365671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0N6"/>
    <dbReference type="FunCoup" id="A0A0D2X0N6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0N6"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0N6"/>
    <dbReference type="OMA" id="WAEKWNH"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.20:FF:000001">
        <property type="entry name" value="Pterin-4-alpha-carbinolamine dehydratase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="101" mass="11408" checksum="4D1E1BBC495D3ADC" modified="2015-04-29" version="1">MLQKLTPEARTAKLAQLPGWNEVAGRDAIRKDFVFADFNQAFGFMTRIALKADKMDHHPEWFNVYNQVHITLSTHDCGGLSERDITLATFIESVAAESRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0X7</accession>
    <name>A0A0D2X0X7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349770.2">
        <property type="nucleotide sequence ID" value="XM_004349720.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0X7"/>
    <dbReference type="FunCoup" id="A0A0D2X0X7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0X7"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0X7"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0X7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="221" mass="24349" checksum="DD95FB5E5991CC23" modified="2015-04-29" version="1">MFGCLASGRLVQTEPVAVDPARVVFTIDDADKINHLVVFLLGHIPFDEGFGGAVYFGWPSAEGPVWQYLGFISNLKPSAIFRVSKTRPTQSEAAAPFASMYQNAAPMGGFQQNFGGSMMDSEQAQYPAYMYDASSIQAQVGISIEPLDDIAQQTPLADEASQAGGMIGFTQAMLANFFNYAMSFSTPTPKYNEEYVPTSVVKQWYESFERKLALNPNFWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1A6</accession>
    <name>A0A0D2X1A6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Max protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1A6"/>
    <dbReference type="STRING" id="595528.A0A0D2X1A6"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1A6"/>
    <dbReference type="OMA" id="FGCLRDA"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1A6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000019">
        <property type="entry name" value="Myc proto-oncogene protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="13062" checksum="144EE431EB0AA9AF" modified="2015-04-29" version="1">MEENTISQGDEYDSDDMEDVQPDASGRHVKRAHHNALERKRRDHIKEKFNELRDTVPSIAGDKASRSLILNRATEFIVTMKQRNTAHEAEIDAIRKQNETLRKQILDLENGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X205</accession>
    <name>A0A0D2X205_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348627.1">
        <property type="nucleotide sequence ID" value="XM_004348577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X205"/>
    <dbReference type="STRING" id="595528.A0A0D2X205"/>
    <dbReference type="eggNOG" id="ENOG502SDZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X205"/>
    <dbReference type="PhylomeDB" id="A0A0D2X205"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48979" checksum="9A2C0DC11C0D0A7C" modified="2015-04-29" version="1">MYRLLAEVDRSPLSELLPFEVAGALLAALAQQQPTFRRVFGLIGGAVAKAVSTTFIILVVAAFFARHVLDNKNTIAKTHSPEIVQARMLARFEAGSVIPRFEKYHVSRPDAVAMLQKVLRPAPLETYTVVVGEVGCGKTSAVHDAIRANSTGIVYHIVKSEVLVSMPGLLAGSLAFEFNQFTFTAGYFKDRGIEMHQIASAEEPFKSWAILELGLRDVAAQFKAKHGHVATLVIDAVDQIAQQGPALLHVIQNFAKAAADEQLLNVVLVTCDGSNLPELKASSAMTRARIVEVSDITDEQAVDFLLHRGVNEDSAKRAVAEIAGGRFVLLNRVTKQLGRGQQVNQIFEEFRVDTADSLQRLIDDLALYNATSDVHKTLCDLTHGALHIDIVHCALGKDLTKKLLATNINILAYHPNDTYTLHSRHVQRSVSTLLNCTRPLGRPLFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X222</accession>
    <name>A0A0D2X222_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363727.2">
        <property type="nucleotide sequence ID" value="XM_004363670.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X222"/>
    <dbReference type="eggNOG" id="KOG1025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X222"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X222"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="657"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="978"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE91804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114354" checksum="E81922966C53D2BE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X289</accession>
    <name>A0A0D2X289_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363996.1">
        <property type="nucleotide sequence ID" value="XM_004363939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X289"/>
    <dbReference type="STRING" id="595528.A0A0D2X289"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X289"/>
    <dbReference type="OMA" id="GGNEHIQ"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X289"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="478" mass="51617" checksum="3FA0461BB242C2A7" modified="2015-04-29" version="1">MSASSPPAQGQANSSHPTENRQQSDNVIVAYYAKKVTDVNSLEEISENMNQLPQLVSGMLSDDPSVQFDCTIKVREILSKEKKPPLEAVVAIENGAVIPTLVAFLDRAENPILQFEACWALTNIAVGASEFVDRIVQHGAIPRLVALVSNRDANIAEQAVWALGNIAAASLQLRDLVLKAGVAAPLFALIRHSCHMGVMRTAVWALSNLCRKKPPPRLELLPGVVELLLILLYVRDEQTLSDTCYTLFFLADSVNQFLRTGFVERVVQLLLFQNSAVVLPALRLIGQILAGDNQVTQLVLDTNVLVHLPALLQGNHEDIQAYACLAISNITAGTTEQIEAVFAANLVPLILNLLRNGAPNTRKEAAWALANACAGGSATQLDQLIEAGVFLPLCDMLSCTSANLVRTILIAVNRMLSVPAAAVSRDLLTQLKANNYHIAVTGLTRHSTDGVSEMATQLARLHLKNNDPVESPAPPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2H0</accession>
    <name>A0A0D2X2H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2H0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2H0"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2H0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2H0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="15">
        <location>
            <begin position="228"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="871"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1157"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1157"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142053" checksum="CE765A4AF73A5327" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2H8</accession>
    <name>A0A0D2X2H8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270332.1">
        <property type="nucleotide sequence ID" value="XM_011272030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2H8"/>
    <dbReference type="STRING" id="595528.A0A0D2X2H8"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2H8"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2H8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="945" mass="102566" checksum="28F2627D0E630570" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3J1</accession>
    <name>A0A0D2X3J1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_005043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3J1"/>
    <dbReference type="FunCoup" id="A0A0D2X3J1">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3J1"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3J1"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3J1"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="E2 binding" evidence="14">
        <location>
            <begin position="441"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE94399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="525" mass="57419" checksum="E347C96EB14CC6C8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Q0</accession>
    <name>A0A0D2X3Q0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346982.2">
        <property type="nucleotide sequence ID" value="XM_004346932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Q0"/>
    <dbReference type="FunCoup" id="A0A0D2X3Q0">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3Q0"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3Q0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3Q0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="688"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="787" mass="84673" checksum="7775661BFA3CBD94" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3R2</accession>
    <name>A0A0D2X3R2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Triple QxxK/R motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3R2"/>
    <dbReference type="InParanoid" id="A0A0D2X3R2"/>
    <dbReference type="OrthoDB" id="10049402at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9814" checksum="752766144CB254DC" modified="2015-04-29" version="1">MGRSSGLGGGGGGGGGGPDRIDARPIEHYRRSIGRQENRGRSKQATLSIKNTAQIRRTGEKSVTVPKEAYTSLALLALVIVAAGLYWWMHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3V1</accession>
    <name>A0A0D2X3V1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3V1"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3V1"/>
    <dbReference type="OMA" id="RFECDAN"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3V1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56283" checksum="8EE4F27A981AD8DE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3X4</accession>
    <name>A0A0D2X3X4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3X4"/>
    <dbReference type="STRING" id="595528.A0A0D2X3X4"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3X4"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3X4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF291">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="4">
        <location>
            <begin position="563"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1218" mass="130005" checksum="DEA21316ED1275EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3X9</accession>
    <name>A0A0D2X3X9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346254.2">
        <property type="nucleotide sequence ID" value="XM_004346204.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3X9"/>
    <dbReference type="STRING" id="595528.A0A0D2X3X9"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3X9"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3X9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000011">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="250"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1005" mass="108240" checksum="B918CD9DD7B2E5DD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X405</accession>
    <name>A0A0D2X405_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_005694</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346367.1">
        <property type="nucleotide sequence ID" value="XM_004346317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X405"/>
    <dbReference type="FunCoup" id="A0A0D2X405">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X405"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X405"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X405"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="92"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="406"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE95219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="557" mass="62959" checksum="8D5753E8AD4DDAE1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4P4</accession>
    <name>A0A0D2X4P4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expressed sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4P4"/>
    <dbReference type="eggNOG" id="ENOG502QWKE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4P4"/>
    <dbReference type="OrthoDB" id="9995764at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4P4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019534">
        <property type="entry name" value="DUF2452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553:SF1">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 1 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C1ORF50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10504">
        <property type="entry name" value="DUF2452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="334" mass="36313" checksum="A30DF2E29E758711" modified="2015-04-29" version="1">MDPKQNQVASHTPSSFISYHTVINKHMSSSGASTAGNGAGASDMAAERLAVAQYATVNADALGTVQLSSLDTNVLTATAGAPREHLVDLARAIQDADVTLRATTGAKMQVIVDQIRLLQMQARVFMEEARRDADLHRAACNFTKRAGTTYHLYRRDGPQDDGVPYLSLLSPEEWGARGTPHTFVGSYRLEADQTWTPVERIRHREDNSAFVQRLLGPNIIKYTDAPLFTQQLNMIDNSYSSVAPQQLLGPSSNSSGTSESLGSAGGQQPQAVQSYQSSQSMMMMMTPQQQQQNPMAQQILNQSTLVTPVPKRQLGNAVPLPASVRQPEGFEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4U2</accession>
    <name>A0A0D2X4U2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343668.1">
        <property type="nucleotide sequence ID" value="XM_004343618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4U2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4U2"/>
    <dbReference type="InParanoid" id="A0A0D2X4U2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255510" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1265" mass="134357" checksum="5372EC5AD3636215" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Y4</accession>
    <name>A0A0D2X4Y4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Y4"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Y4"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Y4"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Y4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="315"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="182"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="583" mass="63902" checksum="0EE74E473E606F21" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X530</accession>
    <name>A0A0D2X530_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343439.1">
        <property type="nucleotide sequence ID" value="XM_004343389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X530"/>
    <dbReference type="InParanoid" id="A0A0D2X530"/>
    <dbReference type="PhylomeDB" id="A0A0D2X530"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48811" checksum="EFB1FE4D45DB3382" modified="2015-04-29" version="1">MGADPAPNENCSFPFSGEHCDKTFADELGGSYIAAQAIFLSANSLLVIIGCVCSYYITRKSGGFTWSVDNALVYMATVMALLGIIRCVDGNAWSDMYPMWFASLLYDVTTCLLITMWLTLVNSWATFVCKAVLSRTHNFGRIAKITFRASLVYSWITQPLSTLITYTIEFYVGKCLRYAFSTLIIAIWILLSSYFAFIIHRVLVEAQKRYGDVQNSSSSNHQHKSDSHSKEHESSSTAHKSGDNTSSKGKGRRVEGVASRRRRLAVKRIQRMNLLLILLECLGTFAVAYSLVSWVQNKYSLTPPNVIPLPQGSDIVFEFIFDIMFVIVCVAVFWFFRPTRETKASNSRAAADQDDAADVEATVEIGPPRVSSRHASGGTLSMSYVGMMSPWKGSSTLGDDSPSPARPASETTVEMGTTASTPEPSDTTVELGTASAPEIPPQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5M3</accession>
    <name>A0A0D2X5M3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342694.1">
        <property type="nucleotide sequence ID" value="XM_004342645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5M3"/>
    <dbReference type="STRING" id="595528.A0A0D2X5M3"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5M3"/>
    <dbReference type="OMA" id="RWEYSET"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5M3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="9">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="509" mass="53258" checksum="86318307A13DE8D3" modified="2015-04-29" version="1">MASKRKIVESDASEFDAFADTHDDMQAFAAAAQMAEAQMTGTRAGTRAGAGAGAGTGSGHHSSSSSSSLSSSVAGSTSTASSATPWVLSQELLVAAPGGHPMILGGGDAPGRLHAPGSLLEAHFGHLRTAATEPAGSGSGVGRPGSSSSSNAGVGVGASSAQVKRASSTPTLTRGGGATCLQVNKRQEHNPMLKCISGTVPYEIVEMVPDFVMGRSVCALYLSLRYHLLHPEYLWQRMRELRNMYELRILLILVDIKDTQRVLRELTTVTVRFKFTVVLAWSEDEAARYLETYKMYESKPADALKERIDTDFLSRVTDILTSIKSVNKTDVITLLSTFGSLKNIANATPEQLSRCPGIGEHKVRRIYEAFHQPFTPDAVKGASKTSVSTAPPVRSASTAKTAATFDIASAFDRHDTLPVSSSSSTGAASAATTISGASLHPVALLAPSSLHGGQAASSDSSSAASSTATGPRIGQFRMRTTSSTTAPPSTGQAIVSDWRQHLNSNAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U032</accession>
    <name>A0A0D2U032_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U032"/>
    <dbReference type="STRING" id="595528.A0A0D2U032"/>
    <dbReference type="InParanoid" id="A0A0D2U032"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U032"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10609" checksum="419B3152FCE5266F" modified="2015-04-29" version="1">MLWMKSWFADPWWNPMQEEQAIDRVHRIGQMREVIVERLVIPDTVEERVLLLQQNKQMLANAVLDEAGRAASQRLDLNDLMYLFGLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0A2</accession>
    <name>A0A0D2U0A2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365103.2">
        <property type="nucleotide sequence ID" value="XM_004365046.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0A2"/>
    <dbReference type="FunCoup" id="A0A0D2U0A2">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0A2"/>
    <dbReference type="eggNOG" id="KOG2034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0A2"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0A2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="48"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="639"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="872"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="998" mass="113575" checksum="B9CAED290BFA5B31" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2S4</accession>
    <name>A0A0D2U2S4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2S4"/>
    <dbReference type="InParanoid" id="A0A0D2U2S4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="12190" checksum="862CE1C268F7F43B" modified="2015-04-29" version="1">MVDRAVNGSAPHPQPQTPKRCFFRVLGPFTIQTESEQMRARMLLAGPKGGLEPNGFCIGSKHFDSPRLHRSLPRPNGLHSVSSRRNPIKWTVLYRIGRATSARGERMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4S9</accession>
    <name>A0A0D2U4S9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364353.1">
        <property type="nucleotide sequence ID" value="XM_004364296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4S9"/>
    <dbReference type="FunCoup" id="A0A0D2U4S9">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4S9"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4S9"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4S9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="111"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="290" mass="31972" checksum="2CC9133313245002" modified="2015-04-29" version="1">MSKASTSKQSTLTAFIKKRPAEDPAEGSDAAASKRTATSAADDQDAVEKRGVHKLGDNFKLEKETMGNTWFNALRPEFDKPYFAKLKTYLANEYKTQTIYPVEADVYSWSRYCSLPDVKVVIVGQDPYINENQAHGLCFSVSMKAAIPPSLRNMYTELASDIPGFKPPKHGNLESWSKQGVLLLNAVLTVRAGASNSHAGQGWEEFTKEVLSTVSRRRTNVVFILWGNYAKKLGKLIDKSKHTVLEGAHPSPLSVKLFTGCKHFSKCNDALEASGQQPINWNSVNEAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8A3</accession>
    <name>A0A0D2U8A3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349238.1">
        <property type="nucleotide sequence ID" value="XM_004349188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8A3"/>
    <dbReference type="FunCoup" id="A0A0D2U8A3">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U8A3"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8A3"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8A3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="310" mass="34811" checksum="855F462B5C470426" modified="2015-04-29" version="1">MAFVKVVKNKAYFKRYQVQFRRRRQGKTDYYARKRLITQDKNKYNSPKYRLVVRFSNRDIVAQIASAKIEGDVILAAAYAHELPRYGVKLGLTNYAAAYATGLLLARRLLTKVGLADAYKGVEKATGEEYHVEEEGEKRPFQAFLDVGLARTSTGARLFGVLKGAVDGGLNVPHSTRRFPGYSAESSTYKAEAHRDRIFGKHVADYMRTLQKEDPEAYKRQFSKYIAAKIGADQVEGVYKAAHAAIRADPTHKSTAKPAPATRKSYHRSKITLAQRKNQTKQRIESIAKKGHKTGKAKEAEPEAVAPQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9H9</accession>
    <name>A0A0D2U9H9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348639.1">
        <property type="nucleotide sequence ID" value="XM_004348589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9H9"/>
    <dbReference type="eggNOG" id="ENOG502SUIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9H9"/>
    <dbReference type="OMA" id="VEYGMEP"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31931" checksum="BA56BCDA10C38D63" modified="2015-04-29" version="1">MVSPGAVRFVQVLSVLSCIGVIVCGILQLKNGGLGSGSSLNLQYCETSPTEACWEDNYGPNAGYAMTLYGGVLVAFGCILFMVGARSEGWFPALQPWRYCGVALLGTGICTLGSAANLGIILGGFAILVGLTMFLMAVISNVEYGMEPGKEPWIPLGIITFVQLMAALWAIGAIAVGLMCIISQARNDTKLEWCKTQSGQDDEVCWTQTYNTKFAYCCYGAGLMIFGAIAFIATIRFKNWFPSLYQWNVLSLVHVFVGVISLGATGNTGIILGSLEIGFGGIMMLMFIFFSVTSGPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAL7</accession>
    <name>A0A0D2UAL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAL7"/>
    <dbReference type="FunCoup" id="A0A0D2UAL7">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAL7"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAL7"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAL7"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000004">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="10">
        <location>
            <begin position="248"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="351" mass="37593" checksum="E288E39E5898D3BC" modified="2015-04-29" version="1">MTVYATSSPFVTLIFVLSMSGRVVRVGSRKSELALIQTNSVIARLKAIYSDCTFELTTMSTTGDNVLDRALSKIGEKSLFTKELEVALAQNEVDLVVHSLKDLPTTLPPGMTIGAICKRDSPYDAVILRAKFAGLTLATLPEGSVIGTSSLRRIAQLRRAFPHLVFRDVRGNLNTRLRKLDDAETYAGLILAEAGLDRMGWQGRVSEILKPEVTLYAVGQGALAIECRENDTATLELLKPLQDNDTTLRCTAERAFMRSLEGGCSVPLGVHTEFDASSGQLRLRGGVFSLDGTDSRFAERTITATDAATASGLGQALATEMIAAGAAEILKQARETTHAAAAASIDAAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UC69</accession>
    <name>A0A0D2UC69_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348430.2">
        <property type="nucleotide sequence ID" value="XM_004348380.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UC69"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1529" mass="163126" checksum="42B968D740878879" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDP5</accession>
    <name>A0A0D2UDP5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347822.1">
        <property type="nucleotide sequence ID" value="XM_004347772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDP5"/>
    <dbReference type="STRING" id="595528.A0A0D2UDP5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDP5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="31859" checksum="16CF110025A227BB" modified="2015-04-29" version="1">MDLLADIEAELASRFGSTFSITSSASSAAAAAQPAAASEKARVCDAASAVAVESDAASNNENTSPQNNSILAAESEQAPSSPVRKPRKPVESLDPTTGRRPAIGTLQATSPASPTRKGPRGIPQVTSPAAFESGVPISQKVLLACLNNCPAELAVLLQVKTISQNTLDESLRISAAFGHTKCALLLVQRGSNTNSRADDNSTVLHFACRKADVELVQAVLQHDADVGARDDDYVTPLDIAAEQGLERIVALLLDRAIEVAKHSKPPLSASDLILAESRAKNCYFYQCAEAIGNARRTLYPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF49</accession>
    <name>A0A0D2UF49_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FGGY-family pentulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF49"/>
    <dbReference type="STRING" id="595528.A0A0D2UF49"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF49"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF49"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="446" mass="47711" checksum="5AE4B351B04B90F0" modified="2015-04-29" version="1">MDHRASKEAAEINQTNHNVLNYVGGKVSLEMQMPKLLWLKRNMQEACWTRAAHFYDLPDFLTFRATGSSVRSLCSLVCKWTYMHHPAHVAANAATVGWSNSFLQQVGLDDLATDNYARLGTQVQAPGSPIANGLSAAAAAELGLLPGTPVATSLIDAHAGGVGALGARSDASTSVNLPERLALICGTSSCHMALSAEPLFVPGVWGPYYSAMVPELYLNEGGQSATGKLIDHIIKRHAAYPELASQALARQRAPTALLTETLTVMAARAGVPIATLSRNVHVLPYFHGNRSPLADPSLRGSIVGLSLSETIEDLAVLYLATVQAIAYGTRHILETMASRGHSITTLVACGGLAKSSLFVQQHADVSGCTILLPKEEESVLLGAAILGACGSRHFPSIQDAMASMSGTASTVTPDATLRSFHEAKFKVFRRMHEDFLFYRTTMEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFF5</accession>
    <name>A0A0D2UFF5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347328.1">
        <property type="nucleotide sequence ID" value="XM_004347278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFF5"/>
    <dbReference type="FunCoup" id="A0A0D2UFF5">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UFF5"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFF5"/>
    <dbReference type="OMA" id="DNVASKW"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFF5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000167">
        <property type="entry name" value="Cell division control protein 42 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="191" mass="21100" checksum="9DB52CDADFCAD0BC" modified="2015-04-29" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPASFENVREKWVPEITHHCPKTPFLLVGTQMDLRDDATTTEKLAKNKQKAITVEQGNKTATDLKAVKYVECSALTQAGLKNVFDEAILAALEPPESPKKRKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFJ1</accession>
    <name>A0A0D2UFJ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004619</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFJ1"/>
    <dbReference type="STRING" id="595528.A0A0D2UFJ1"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFJ1"/>
    <dbReference type="OMA" id="HATRIMS"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFJ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="242"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="865"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1090" mass="115515" checksum="16D8C0A54B7ED336" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJX7</accession>
    <name>A0A0D2UJX7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal acetyltransferase B complex subunit NAA25 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345450.2">
        <property type="nucleotide sequence ID" value="XM_004345400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJX7"/>
    <dbReference type="FunCoup" id="A0A0D2UJX7">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJX7"/>
    <dbReference type="eggNOG" id="KOG2053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJX7"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="103929" checksum="E319DF1B760DCD66" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKN4</accession>
    <name>A0A0D2UKN4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345627.1">
        <property type="nucleotide sequence ID" value="XM_004345577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKN4"/>
    <dbReference type="FunCoup" id="A0A0D2UKN4">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UKN4"/>
    <dbReference type="eggNOG" id="ENOG502S7WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKN4"/>
    <dbReference type="OMA" id="VILCAHR"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKN4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16418" checksum="3837306EF32612E0" modified="2015-04-29" version="1">MDDDDVSYDESLKARIKASVHYTVGKICQREESEMGVKCSKQFLAALAELTYGKCGSLASDLESFAKHAKRSTIQVEDVKLCARKNPSLAKLVAEKATDLEAETQERLSKKRRKDNKPADEDGESASDAAPSAAVASAATGATHKSKKVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKQ8</accession>
    <name>A0A0D2UKQ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345650.2">
        <property type="nucleotide sequence ID" value="XM_004345600.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKQ8"/>
    <dbReference type="eggNOG" id="KOG0476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKQ8"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKQ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="607"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="683"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="868" mass="95402" checksum="B658512D767C3ECB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM96</accession>
    <name>A0A0D2UM96_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_006545</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;2)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:13802"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="ChEBI" id="CHEBI:138067"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345294.1">
        <property type="nucleotide sequence ID" value="XM_004345244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM96"/>
    <dbReference type="STRING" id="595528.A0A0D2UM96"/>
    <dbReference type="eggNOG" id="ENOG502QSG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UM96"/>
    <dbReference type="OMA" id="NYETEIH"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UM96"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13937">
        <property type="entry name" value="PANDER_GnT-1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000252">
        <property type="entry name" value="Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039474">
        <property type="entry name" value="POMGNT1_PANDER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="ILEI/PANDER" evidence="21">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="782" mass="87952" checksum="E99F71DAABA281A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPA4</accession>
    <name>A0A0D2UPA4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2063"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2063"/>
            <end position="2106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2198" mass="234425" checksum="FEB2DEE615A9DFBC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQY5</accession>
    <name>A0A0D2UQY5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343155.1">
        <property type="nucleotide sequence ID" value="XM_004343105.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQY5"/>
    <dbReference type="eggNOG" id="KOG1551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQY5"/>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="533" mass="57612" checksum="71796115FF8EAB5B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFB0</accession>
    <name>A0A0D2VFB0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364937.2">
        <property type="nucleotide sequence ID" value="XM_004364880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFB0"/>
    <dbReference type="InParanoid" id="A0A0D2VFB0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="71915" checksum="EE70A82D3F5EFD08" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFC6</accession>
    <name>A0A0D2VFC6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Folic acid synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000086</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364957.1">
        <property type="nucleotide sequence ID" value="XM_004364900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFC6"/>
    <dbReference type="SMR" id="A0A0D2VFC6"/>
    <dbReference type="FunCoup" id="A0A0D2VFC6">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFC6"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFC6"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFC6"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="15">
        <location>
            <begin position="279"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="555" mass="60241" checksum="D879A4DC7DC2F865" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFT2</accession>
    <name>A0A0D2VFT2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000228</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365099.1">
        <property type="nucleotide sequence ID" value="XM_004365042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFT2"/>
    <dbReference type="STRING" id="595528.A0A0D2VFT2"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFT2"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="483"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1263" mass="136574" checksum="81E34C2956FC2E48" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFX7</accession>
    <name>A0A0D2VFX7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_000270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFX7"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFX7"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000088">
        <property type="entry name" value="Receptor protein-tyrosine phosphatase LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253551" description="protein-tyrosine-phosphatase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1515"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="223"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="480"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="576"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="882"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1191"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1292"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1407"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="1604"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="1776"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="1891"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="2058"/>
            <end position="2131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2146" mass="229964" checksum="E47CFACBA70B9F47" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGH2</accession>
    <name>A0A0D2VGH2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365408.1">
        <property type="nucleotide sequence ID" value="XM_004365351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGH2"/>
    <dbReference type="STRING" id="595528.A0A0D2VGH2"/>
    <dbReference type="eggNOG" id="KOG3773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGH2"/>
    <dbReference type="OMA" id="LERMAFQ"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGH2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="341" mass="36743" checksum="228D6EDEDF817B2C" modified="2015-04-29" version="1">MNFSFSGAGFLGAYHLGVAQCLVNKLGRETLRRSQFIGTSAGALTAAVLATEADIDQCMVQTTRLAKYWANHPVTRLLTGQVLTNVVSIVLNAPADMLTATAGVAMPSPAQVAATTPIQDPDTDAPFIQEVERSLRAVLPLDALERMAFQTPRSTLAATAASTATPSRASPSRVTVVVTRAVPVPLARRFSQFTSYDDLIAALLCSSFIPGYCGRVPPLFRGANKYIDGGLTDNWPQFRPDELIAPVPELPGPTLPARTIKVSPFLGTFDICPPPDDSVPYMLAPVLPWTNSDKVQVAPANMRAIYDALLPRDPKLIPMYFQNGYDDATRALRQLRLCEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH52</accession>
    <name>A0A0D2VH52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365643.1">
        <property type="nucleotide sequence ID" value="XM_004365586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH52"/>
    <dbReference type="FunCoup" id="A0A0D2VH52">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VH52"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH52"/>
    <dbReference type="OMA" id="INQGTHQ"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH52"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="387" mass="42301" checksum="D5C522FB8B2A6806" modified="2015-04-29" version="1">MADATTAPTATATRVCSGAGCGKPAKMQCPTCLKNSIAGDKTFFCDQDCFKRNWAAHKLVHPAAPLNNPWPGFEFRGPLRPYPQTPMRTVPSHIPPPDYSVSGIPESERREPQSSIATPLSPERIAKMRVACRLTREVLDIAVAAVRPGVTTDEIDRIVHEATVARNAYPSPLNYRNFPKSCCTSVNEIICHGIPDLRPLQEGDIINIDVSVYYDGFHGDLNETVFVGKVDAASETLVRNSWECLENAIAMVKPGVAFRDLGNVISKTAHAANHSVVRTYVGHGINELFHTNAPVIPHYAKNKAPGVMKAGHVFTIEPMINAGSWQDVTWGDEWTSSTVDGKRSAQFEHTLLVTETGVEVLTARPHTTKPHFYDQLEAQKAEAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHA5</accession>
    <name>A0A0D2VHA5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHA5"/>
    <dbReference type="STRING" id="595528.A0A0D2VHA5"/>
    <dbReference type="InParanoid" id="A0A0D2VHA5"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="621" mass="69646" checksum="EE36064F4B897896" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJQ9</accession>
    <name>A0A0D2VJQ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJQ9"/>
    <dbReference type="InParanoid" id="A0A0D2VJQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="108" mass="11743" checksum="194F01A00AFEEC87" modified="2015-04-29" version="1">MVAHSTCRWSHAVLLTCTQFVHKSPATARSLWAEKHASSWHGTHRSENQSATATQLYMCAARTLPDMEAISGGASESQNTASSWEETSAWNAASLSRTVAAMNNFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMR3</accession>
    <name>A0A0D2VMR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349367.2">
        <property type="nucleotide sequence ID" value="XM_004349317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMR3"/>
    <dbReference type="InParanoid" id="A0A0D2VMR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="9834" checksum="ABEACC5BC310FAEE" modified="2015-04-29" version="1">MVNDTAVMSDANTPPTVPEDCLQCRLVHIGVFAAAGAWTFFQRTQVPKTATTSRATLAVVGTGLFALSATRAFIPLNQSATPAPSPASSSPPSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQC1</accession>
    <name>A0A0D2VQC1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363458.1">
        <property type="nucleotide sequence ID" value="XM_004363401.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQC1"/>
    <dbReference type="InParanoid" id="A0A0D2VQC1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="18723" checksum="C4BB3E89FFBEB2DB" modified="2015-04-29" version="1">MQEELRSWFASYGIPYPDQALSIGVIEKTIAIHGKERWTRAVRRDLMDEAIELFEEARARLQRQANRMFSNLQEFNKLLRFLGRSPQPSTNKACEAMSSIHVNIYDLIAAYNADNSGTFNGRTFPSVKELAKYSRAKNLIFPRDKAKSEGLRHFLRHFFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQE9</accession>
    <name>A0A0D2VQE9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363498.1">
        <property type="nucleotide sequence ID" value="XM_004363441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQE9"/>
    <dbReference type="InParanoid" id="A0A0D2VQE9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44434" checksum="7ACF5CF369B48F2C" modified="2015-04-29" version="1">MAGDDEIIYTDMTSYWNPFEVWAVAMCTLVLSLQFLVALYMVIHRDWKPFKAKQPWSLFLGASAAIISFVAELHSQILIPNDYPVLSACALWRQWFFVTFGMGLISACLLYRLFMRWIVLDFLSSRFAATHRKIDRTFIQILGVGVIYVPMLVLSIVNSTAGETSLGPLVLANGQVIQVCYTRTKVLNYSLNCFIGIYCAAMALWWTHALRDVRRSFNEFRAGRPALIFAVCCLLSYLALLFVIDSSKYYYRAVFLLLNTGITSPIFCAVVFDVITSWFVRRQEEEDVFEAGLAMTMLTHAPRRGRRGNTYDERNHPGSKASTHASGDSGRNTPKATTVEYTEYNVELEEEMDDEQVVVGVEEFVPTGMQSPAPNSVVAQPNPGAPPAADSPPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS94</accession>
    <name>A0A0D2VS94_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 38 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS94"/>
    <dbReference type="eggNOG" id="ENOG502QVYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS94"/>
    <dbReference type="OMA" id="TNFPMWW"/>
    <dbReference type="OrthoDB" id="197879at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10791">
        <property type="entry name" value="GH38N_AMII_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032482">
        <property type="entry name" value="DUF5054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16477">
        <property type="entry name" value="DUF5054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253836" description="Glycoside hydrolase family 38 N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80757" checksum="BAF2A87D1A1BC102" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTK7</accession>
    <name>A0A0D2VTK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTK7"/>
    <dbReference type="InParanoid" id="A0A0D2VTK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="21654" checksum="C41847005E843752" modified="2015-04-29" version="1">MSFAGSFAAPQLPFAPSLLLGSTGVLDGGISLPPQNFLSNREELVVTRLDQIASLGAHSRIIGVSPQALASLQQQAANAAQPAPAQVQPGVAATVASGHPTTAQPQTPAQAIAVPVRLPRSTPARPSQFIAGVTGVLQVDQSFGSPGTAARSPLLPNPSFATVSAVSRHPFAHDRHASSSAADLDRAFTADDDESQLDDDIDADDDHFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTY6</accession>
    <name>A0A0D2VTY6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347065.1">
        <property type="nucleotide sequence ID" value="XM_004347015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTY6"/>
    <dbReference type="STRING" id="595528.A0A0D2VTY6"/>
    <dbReference type="eggNOG" id="ENOG502QVBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTY6"/>
    <dbReference type="OrthoDB" id="744564at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTY6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044599">
        <property type="term" value="C:AP-5 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028222">
        <property type="entry name" value="AP5Z1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055450">
        <property type="entry name" value="AP5Z1_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056856">
        <property type="entry name" value="TPR_AP5Z1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056857">
        <property type="entry name" value="TPR_AP5Z1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14764">
        <property type="entry name" value="SPG48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25153">
        <property type="entry name" value="TPR_AP5Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25154">
        <property type="entry name" value="TPR_AP5Z1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-5 complex subunit zeta-1 N-terminal TPR" evidence="3">
        <location>
            <begin position="330"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 ARM repeats" evidence="2">
        <location>
            <begin position="491"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 C-terminal TPR" evidence="4">
        <location>
            <begin position="791"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1099" mass="116597" checksum="53755770AD3E62F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV11</accession>
    <name>A0A0D2VV11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346403.1">
        <property type="nucleotide sequence ID" value="XM_004346353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV11"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV11"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43573" checksum="BE7A46BB2F1DC512" modified="2015-04-29" version="1">MLSYQNITPSPRELNDKVTNTPHDFSLYGEEVGDAGAPAIAEALKVNTTMTWLALWQNQIGEVGARALAETLKVNETVTKLDIWRNQIGDAGASAIAEALKVNTTVNMVDLGGNQISDIGASAIAEALKVNKTVTKLDLDENQIGSAGAQALAEAFKVNTTVTQVDLGENLIGDAGAQAIAELIKVNKTLAWLNLSWNCIGDVGIQAIADAREFHPSPTALRISFQFSPLVLSLLPRLATADDLQTVFGLLTSGLELEDQLASLPALPAEIADLIMDEACYWQGLRRTRPNLSNVHFLQVRLPRSSTANSIRVKAIQVLLGIKHIHANNPEQCVVKLIVRDEQGAVRYECTAKPTLVDSTLWRVTILPASHPVIRQMHEGWKVDVQPGIYVPFLSFYVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV93</accession>
    <name>A0A0D2VV93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345425.2">
        <property type="nucleotide sequence ID" value="XM_004345375.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV93"/>
    <dbReference type="STRING" id="595528.A0A0D2VV93"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV93"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="334"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="10">
        <location>
            <begin position="462"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="643" mass="70868" checksum="9A089881D7C8D09B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVI1</accession>
    <name>A0A0D2VVI1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-sialoglycoprotein endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345531.2">
        <property type="nucleotide sequence ID" value="XM_004345481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVI1"/>
    <dbReference type="FunCoup" id="A0A0D2VVI1">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VVI1"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVI1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="201"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="626" mass="66014" checksum="E3EDA28C2C2AF149" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW55</accession>
    <name>A0A0D2VW55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW55"/>
    <dbReference type="InParanoid" id="A0A0D2VW55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="12626" checksum="2A6FD14C2F68BE82" modified="2015-04-29" version="1">MSYSQDRQEFSVRRPLSPFAADRSPSEVQRPRVEQLPPAAVGRERLEAEIARLNAALAHSQDRLRHYEDLATATRNAGNIAEAQQYASQAQNWLATIAPTTQLLLGARFIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWT6</accession>
    <name>A0A0D2VWT6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345170.1">
        <property type="nucleotide sequence ID" value="XM_004345120.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWT6"/>
    <dbReference type="STRING" id="595528.A0A0D2VWT6"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWT6"/>
    <dbReference type="OMA" id="WIDVCIM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWT6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="132"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="80474" checksum="19DE9F9D1FD2E1AA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX01</accession>
    <name>A0A0D2VX01_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345220.2">
        <property type="nucleotide sequence ID" value="XM_004345170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX01"/>
    <dbReference type="FunCoup" id="A0A0D2VX01">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX01"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX01"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="11">
        <location>
            <begin position="99"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="764" mass="83043" checksum="6C6FA761FF5F5247" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX73</accession>
    <name>A0A0D2VX73_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345316.1">
        <property type="nucleotide sequence ID" value="XM_004345266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX73"/>
    <dbReference type="STRING" id="595528.A0A0D2VX73"/>
    <dbReference type="eggNOG" id="ENOG502T0N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX73"/>
    <dbReference type="OMA" id="HACVCET"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="523" mass="55959" checksum="0CAEC5D1F191ED75" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYK9</accession>
    <name>A0A0D2VYK9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYK9"/>
    <dbReference type="FunCoup" id="A0A0D2VYK9">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYK9"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYK9"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYK9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000003">
        <property type="entry name" value="apoptosis-inducing factor 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="554" mass="57935" checksum="EC3052BF63A96764" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZM3</accession>
    <name>A0A0D2VZM3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343616.2">
        <property type="nucleotide sequence ID" value="XM_004343566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZM3"/>
    <dbReference type="InParanoid" id="A0A0D2VZM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37621" checksum="0948EB00689B56F9" modified="2015-04-29" version="1">MQSTTTTLKPASQPTTTSTSTSTPTPSNPTSASSSKQQTTKQQQTKPQQGQQQSKAAAPGKLVFKTYTTSPYSLQGPQCMAKQDTAEILELLKRYTLQFPPKSNSRRSFLYIGAQACFTHFRKCAAIVVAQQVQPDAIFRHLATMSHVTSVPMLPLDCDSATLGASIGLNSAIVVGIRSPSAIPKEKQLPLELQQITTKAPAWNIPWIPKLPQLDSSHASKPSLTSDNAVVAAPTAAATSGTLQPLALVHVLATSKPNKQSKKVKRAARKTAELQRKTNTPATSTTPKSNPRTGRPSPSARRAELNAVQTRARQSLVNSNRPGLASTHAAKVASAAKISSSWLESLRATQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W015</accession>
    <name>A0A0D2W015_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4209 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343196.2">
        <property type="nucleotide sequence ID" value="XM_004343146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W015"/>
    <dbReference type="STRING" id="595528.A0A0D2W015"/>
    <dbReference type="InParanoid" id="A0A0D2W015"/>
    <dbReference type="OrthoDB" id="6282368at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W015"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4209" evidence="2">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="686" mass="75711" checksum="3B38F8602EBFD60B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHR2</accession>
    <name>A0A0D2WHR2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHR2"/>
    <dbReference type="STRING" id="595528.A0A0D2WHR2"/>
    <dbReference type="eggNOG" id="ENOG502S2IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHR2"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="605" mass="65917" checksum="41FE9CDCB682C4DF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIX8</accession>
    <name>A0A0D2WIX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIX8"/>
    <dbReference type="STRING" id="595528.A0A0D2WIX8"/>
    <dbReference type="InParanoid" id="A0A0D2WIX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="768" mass="81168" checksum="B3104091C44F073F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ27</accession>
    <name>A0A0D2WJ27_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349895.2">
        <property type="nucleotide sequence ID" value="XM_004349845.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ27"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ27"/>
    <dbReference type="InParanoid" id="A0A0D2WJ27"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="166"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="36233" checksum="DF8B0891012D4A9F" modified="2015-04-29" version="1">MPLESKQLSINADNNAPNEPQARTDSPQKKLWARSLIGELSAIDDNGAMPATDNSSAPASADTTESHGDLTATDSTTSYNLAEDLATNIARANNSKSSSSHPHQRELHSDSHSQRRARHSLDEQQRSAAMNYAETKSTPSSSVDNSTDTATQTPPSGILSSTSSAIVVALDDSAESQAAFEYVLDNLLAENDVLVLVHVYEPFSFVNMDVNEMGYVSSDIFDALSKEHKGIAKRVMQRYVAECNRRNIKCLVKTWEGEPKSGICQIAEQTRAKFLVVGTHRRNALMRLFIGSVSDYVVHNCKRPVLVIPSNIETQQQSAQQSAEVPRRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ30</accession>
    <name>A0A0D2WJ30_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ30"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ30"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ30"/>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="142" mass="15977" checksum="5F343BFDF0FE4C09" modified="2015-04-29" version="1">MSESKVNQGKYAQNPDFKGTTKICFSNKFSTMAEKGVFFEIIVGAPTQQWAKLTSAEASAQDAASLDSMQASLQTVRNNLHEITRLQTQFRHREARHMHTAEDNNHRVFYFSLIECLVLVATSVVQVFFVRQLFGSTKKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJC2</accession>
    <name>A0A0D2WJC2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adaptin ear-binding coat-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NECAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365788.1">
        <property type="nucleotide sequence ID" value="XM_004365731.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJC2"/>
    <dbReference type="STRING" id="595528.A0A0D2WJC2"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJC2"/>
    <dbReference type="OMA" id="STNWIQF"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000064">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NECAP PHear" evidence="6">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="281" mass="29759" checksum="4805E67C55B44450" modified="2015-04-29" version="1">MEFETTVMQKQECFVYRLPPRPSNRGFRAADWDLEHPIWSGRIKVVTQGDTITIKLEDKSTGELFAPCPVDAFPGTAVEAVIDSSRYFVLRIVDPSGRHAFIGLGFADRGDSFDLQVALQDHFKFLHSSREIEKQAAMAKANPQPSLDLGFKAGEKLHINFGKKTGIEAGHASSASANSNASSFILPPPPASGSTVIAPPPSNGGSRVRGHQQQAPATATSSFFGAPAPAATASPSLAGFGQAPPPQQNFAADPFGGGWGQPAAPAAAPQASKDAFDWTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJU9</accession>
    <name>A0A0D2WJU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366025.2">
        <property type="nucleotide sequence ID" value="XM_004365968.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJU9"/>
    <dbReference type="FunCoup" id="A0A0D2WJU9">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJU9"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJU9"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000007">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="239"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="437" mass="48675" checksum="05A0D97CAED1205F" modified="2015-04-29" version="1">MATAMEVIAPEQDRAVANPSASMERFDRATELATVRPDEAAALFHSLIVDDSLADDEALRLREQAVYALSDLYVATKRPTELAALIRTTRGFLSSISKAKAAKLVRTLLDKFLAVTSATQDAVNLIREFIDWTNEEKRTFLRQALEARLIALYIDTRAYSEAIALSTALLKELKKLDDKPLLVEVLLLDSRTFHALANIPKARAALTSSRTYANAIYVPPVLQAALDLQGGVLHAEEKDFKTAYSYFIEAFEGFDSLNHKEALSALKYMLLSKIMLQSSDEVASILTGKIALKYSGSHVDAMRAVESAHKNRSLEQFQQALVQYKAELTDDPNIRSHLQALYDTLLEQNLQRIIEPFSRVEIKHVADLIQLPVAQVETKLSQMILDKKLIGILDQGLGCLDVFAEQPADRTYNASIDTVQFMGQVVDALYKKAQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJW2</accession>
    <name>A0A0D2WJW2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJW2"/>
    <dbReference type="InParanoid" id="A0A0D2WJW2"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="567" mass="56826" checksum="76FB404C451376B3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL09</accession>
    <name>A0A0D2WL09_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dihydropyrimidine dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="7">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_008545</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270127.1">
        <property type="nucleotide sequence ID" value="XM_011271825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL09"/>
    <dbReference type="STRING" id="595528.A0A0D2WL09"/>
    <dbReference type="eggNOG" id="KOG1799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL09"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL09"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000056">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="951"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="985"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE90453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1028" mass="110940" checksum="2B1E4AAC9DEE7F92" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL78</accession>
    <name>A0A0D2WL78_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL78"/>
    <dbReference type="InParanoid" id="A0A0D2WL78"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="111" mass="12794" checksum="16D42AD451847057" modified="2015-04-29" version="1">MQGGRGRERASRRRNSIRHRPLKRPEPRKGGRRKAEEKKGGGILCSHVSPSTLHISERNVLENKKIRGRRRRNKGKLDRMAWLCGGGSFGVSKKRPPQVRHFLLHSNRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN80</accession>
    <name>A0A0D2WN80_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363726.1">
        <property type="nucleotide sequence ID" value="XM_004363669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN80"/>
    <dbReference type="STRING" id="595528.A0A0D2WN80"/>
    <dbReference type="InParanoid" id="A0A0D2WN80"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="439" mass="48234" checksum="2F4AFE49E06BBE12" modified="2015-04-29" version="1">MSLFGRRVPAVRPLESCYTGSDMIPFKVSSFNGGQFSSEHGPANTLQADTSCFSSASRDNVGVLYELGASVAFVSAANSNATQPLSAASSQAHYREMNRVHAARPRRLRFSTNRHLPVADLTSSVADLTSSVADLTPSVADLTPSSMPLRRRFTREFYDFGTSSAADAVVNPTSTLQSQPRYAPDYSGVGTYNWESTTAVRSREPYVPECHADCDPPRADCDPPRADCDTPPAGLTPEDLDLASTEFEAMTSPYPCASPIFDEIMAHRRILRRDAAMPNLSTLWQNFSLVRPALGPTKPPPRENKLLKRFLRPSCFLSEIIIKAPDSGYTSPVREGVIFLSYDAPPRPCVVASYRDISESDFLRRRLSSLSAPHERPDAFFKVDEKTNVATVTLPVARTVRYVYILFLRSHSSADNIDVQFVGFRGLTRPTSTASGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNU6</accession>
    <name>A0A0D2WNU6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_003145</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNU6"/>
    <dbReference type="STRING" id="595528.A0A0D2WNU6"/>
    <dbReference type="eggNOG" id="ENOG502S11J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNU6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Roc" evidence="19">
        <location>
            <begin position="197"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="809"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1182"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE92123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137699" checksum="76D95C59F69FECD4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNX3</accession>
    <name>A0A0D2WNX3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364050.1">
        <property type="nucleotide sequence ID" value="XM_004363993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNX3"/>
    <dbReference type="FunCoup" id="A0A0D2WNX3">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNX3"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNX3"/>
    <dbReference type="OMA" id="NIIDWFF"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNX3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254523" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="307"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="383" mass="41397" checksum="CD9338BF4EA448E0" modified="2015-04-29" version="1">MKLLLISAVVAALCVASSVGLDNGLGRTPQMGFNTWNHFGCNINETIIRSTVDAMIDTGLTAVGYNYINLDDCWALNRTAAGVIVADPVAFPSGIAALASYVHSKGLLFGVYSDAGTKTCAGRPGSLGYEKIDAQTYASWGVDYLKYDNCNAPADQTPMVRYPVMRDALNATGRPIFFSMCEWGDYDPAKWAAPVGNSWRTTGDVSDSWSRIITILEANEPLWKAAGPGGWNDPDMLEVGNGVLSTTEYTSHFTLWALMKAPLIIGCDVTKMTNDTLRILTNTEVIEWNQDSLGIQGHRVKRGLLSEVWMAPLANGRFAVVLFNTDPLLSAHMTVTWAELGLTAGSKYTARDVWQHKNVGLYAGTFDAQVAPKGVVAVTLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ18</accession>
    <name>A0A0D2WQ18_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ18"/>
    <dbReference type="InParanoid" id="A0A0D2WQ18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="16667" checksum="CD1C9D537A1F1427" modified="2015-04-29" version="1">MLLPRVLSVRHLAPVAPHGAHPAASLHGWHSANRGGMGGSGRARSSPTLKNPRAELRFALRGSAVAPGALFLATWHAQLCPLLAQHWARTNYLFNEIEQEYEGSQKQTLGNADIADMSDRLALDPGDDEDDDCQQLFRAIEGAYRRSQDKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ69</accession>
    <name>A0A0D2WQ69_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ69"/>
    <dbReference type="FunCoup" id="A0A0D2WQ69">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQ69"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ69"/>
    <dbReference type="OMA" id="CETRPLN"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ69"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="361" mass="37829" checksum="ED7DCD149D6EED5A" modified="2015-04-29" version="1">MSSTPTLEAIRYTRGSLDILDQLQLPAQTVYVSIPDSRAAWTAIRSMQVRGAPAIAIVAALSVAVELAAAPRAAWPNAQAVADHVRLAFEALCTSRPTAVNLSEAASALTARAAALAASNASVDTTVDALLKAMEDMLLKDVADNRAIGAHGRAAILAAKSQAAMLTHCNTGSLATAGYGTALGIIRALHETGKLSHAYCTETRPYNQGARLTAYELVYERIPATLITDSMVAALMASRKIDAVVVGADRVVANGDTANKIGTYQLAIVAKFHNVPFYVAAPTTSIDLDKADGSMITIEERPASELTQLNGVRIAAADIGVWNPGFDVTPAALITGIVTENGVISARREDGSFDVQSFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQS4</accession>
    <name>A0A0D2WQS4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348011.1">
        <property type="nucleotide sequence ID" value="XM_004347961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQS4"/>
    <dbReference type="STRING" id="595528.A0A0D2WQS4"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQS4"/>
    <dbReference type="OMA" id="HAAPRNS"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="545" mass="57721" checksum="2E69D4DD008478EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRQ9</accession>
    <name>A0A0D2WRQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347446.2">
        <property type="nucleotide sequence ID" value="XM_004347396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRQ9"/>
    <dbReference type="FunCoup" id="A0A0D2WRQ9">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRQ9"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRQ9"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="268" mass="29136" checksum="4A62B94ED6EDEB7E" modified="2015-04-29" version="1">MAAALVDKIMKLGLGLAIAGGVAQTALFNVEGGHRAVILDQFAGIKPDVFGEGTHFKVPYVQKPIFFDVRSQPRSIPTVTGSKDLQNVNITLRILYRPRIDQLPHIVKTLGPTYDEVVLPSIANEVLKSVVAQFDAGELITQRETVSARVREHLTSRAGEFNILLDDISITHLAFGKEFTAAVEMKQVAQQDAERARFVVELAEQNKLASIIRAEGDSKAAELGCHPLCKSPAPVSSSCARLTLPRKLAPPSRARVTWYTFPAATALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRS9</accession>
    <name>A0A0D2WRS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRS9"/>
    <dbReference type="FunCoup" id="A0A0D2WRS9">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRS9"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRS9"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="342" mass="37568" checksum="133FC74A6BBD15EE" modified="2015-04-29" version="1">MFHHFTAISPCSRVGRAFGSIITRSRIHTCVAPLQSRHGQHAHSGDHHTAVKLAFNHYAPPAHHQTTTNSINNNVPLLLIHGLYGSKRNWASIGKALAHDPTAPRHVFTLDLRNHGESPHSDTMSYSAMVSDVLRFMDDRGVSQPPVMLGHSMGGKVVMTLAMEHPDRIAAPIIADMAPFDFLALPEVSELRAIVAAMQKVDLAQATSPSEVEDQLKPTIPNTAVRKFIMTNLAPTHSEHGPRFRWLANIDVIARDFPQLAAFPHAPGLIYDGRAYFLAGSKARYVTLPAAIDAIHDLFPNNTIEYLDAGHWLHAEATTAFLAKVRGYLSAVDAREKSTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRT2</accession>
    <name>A0A0D2WRT2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WRT2">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRT2"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRT2"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="3064"/>
            <end position="3657"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3882"/>
            <end position="4223"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="4236"/>
            <end position="4274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2402"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2496"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2640"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2716"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2411"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2497"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2723"/>
            <end position="2741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4274" mass="466604" checksum="33A245166FDFCAA4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRX8</accession>
    <name>A0A0D2WRX8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRX8"/>
    <dbReference type="STRING" id="595528.A0A0D2WRX8"/>
    <dbReference type="InParanoid" id="A0A0D2WRX8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="129" mass="14037" checksum="AEDCBEC27678C5AA" modified="2015-04-29" version="1">MSSGQSAPLLHPHIGIDALIDTGGQGASGSLHTGRRRRHPDLETVTLTAWECCSYGATPYGKMDGRETLAYLEGGGRLPTPEHCTSDLFSLMFSCWNILPELRPSFTQLIKGLRNFEDGTTSREIGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS38</accession>
    <name>A0A0D2WS38_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270470.1">
        <property type="nucleotide sequence ID" value="XM_011272168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS38"/>
    <dbReference type="InParanoid" id="A0A0D2WS38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="387" mass="41319" checksum="DD09AC6DFB9CF12B" modified="2015-04-29" version="1">MSQQQHNHTMAAFGETLVLESYNAFCEHDADDDGSMVMMMDTSSASSSAASSSASSLTASPFSSDEDIHCSVAATQARLLGVAALAAVASPSPSSSASAAAAAAASGSIGSTLSSSAPMAAASMTDAYRRVTPPSYDTLAAYTQQQQQHQQQQQHDLLDSSSDEDDAILSNTATGTATSSFSSSSSTTVSSSSSPSSSSSSASASASLSQQHQQFIHLSIEDDEDLAEEALLDEEEEEEAEEFATPQDQDVIAAGSSRLHELLRLAAAQKQQLTDSSDSDEDDALDDFEHEWEEELRSNLAASTAYDLDGDSSAAADQQPPRKRTLTFATHTRVAFTHSRDTYDRTCCYRLPQTMEELAAINEEIFMLKWHEMFVHPESLGNNTYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS67</accession>
    <name>A0A0D2WS67_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347651.2">
        <property type="nucleotide sequence ID" value="XM_004347601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS67"/>
    <dbReference type="STRING" id="595528.A0A0D2WS67"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS67"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS67"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="266"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="366"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="641" mass="69676" checksum="93797A3F4A84BB32" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSB4</accession>
    <name>A0A0D2WSB4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSB4"/>
    <dbReference type="FunCoup" id="A0A0D2WSB4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSB4"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSB4"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="580" mass="64330" checksum="DDA1B01FAB060454" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSZ7</accession>
    <name>A0A0D2WSZ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346945.2">
        <property type="nucleotide sequence ID" value="XM_004346895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSZ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WSZ7"/>
    <dbReference type="InParanoid" id="A0A0D2WSZ7"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF24">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="141"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="494" mass="55718" checksum="FB2FD42D3E45636A" modified="2015-04-29" version="1">MTDTQTTTPATAVADSALWHQNKPVVHTGWLVKQGGRRKNWKRRWFAISANQIFYFKDPKDAVPLAAIQLFGNEVRVIPESQEPRKRFCFEIIPGGETKTMMTDNHRTFIMYAATKPEMETWLSYIRKECYAPRGGGMFGTDLAATLEREGRTDDQVPMVVEKTLNYLVQFGLKEEGLFRKSGLAARINKLKEQFAKGENPELDGEADVHVGAALFKMYLRELPEPLLTFQHHGEFIAAAQIYTDNAATTDHATLLVPVRALLSKLPPCNVTLLRFLCQFLRQVLVHEASNRMGIDNLATVFGPCLLRDRQNHDDPLTQLGLSKMINVVVKMFLQEFDILFSDLSVPKALPRSTSWRKTTLIEADLSDDSDDEDATARDRRSGRVRRESSQAESSPTSPTPLSPGPSSASPFLQPDAFPVQHSNTVRASVAEVAESRVKDLEAKVANLEERLKMAEIRYLEEWQTRQHLELVSAELQRKLKDYEEKDGLKSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTG1</accession>
    <name>A0A0D2WTG1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Smarca2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345756.2">
        <property type="nucleotide sequence ID" value="XM_004345706.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WTG1">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTG1"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTG1"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003020">
        <property type="entry name" value="SNF2-related domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="13">
        <location>
            <begin position="320"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="586"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="911"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1284"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1377"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1438"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162848" checksum="A2BD87BD81671AE3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU54</accession>
    <name>A0A0D2WU54_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008921</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270592.1">
        <property type="nucleotide sequence ID" value="XM_011272290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU54"/>
    <dbReference type="STRING" id="595528.A0A0D2WU54"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU54"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="432"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="432"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE95378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="757" mass="81748" checksum="F1A51128DB1C32E3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUL0</accession>
    <name>A0A0D2WUL0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain phosphoinositide-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345680.2">
        <property type="nucleotide sequence ID" value="XM_004345630.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUL0"/>
    <dbReference type="FunCoup" id="A0A0D2WUL0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUL0"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUL0"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="373" mass="40769" checksum="34D04798032B8807" modified="2015-04-29" version="1">MNLANKPRNELLFVNFNQDYTCISVGTKQGYKMYNCDPFAKCYGRFEGGTGIVEMLFCTSLVALVGAGAHPAFSPRRLQIANTKRQSTICELNFVNKILAVKMNRKRLVVVLEDRIHIYDITNMKILHTVDTAANPRGICALSPNSDSNYLAYPASHTDGNVLMFDALNMQASSVMQAHKGPVTCLAFNYSGSMLATSSEKGTVIRVFSVPDAKKLYQFRRGSYPATIYSINFSVDSTRLCVSSSSDTVHIFNLGQEPRQNSGASSSKGGAFSLSSYLPEMLTEMWDPERHFAHFKLPNAGNDVMNVCALSSTLPQAMVVTADGNFYQYQIPKDGGECTLVKQYSILDPSEGKTSRTAASDSPDVGSLADPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC5</accession>
    <name>A0A0D2WVC5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WVC5">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVC5"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVC5"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="1448"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1386"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1573" mass="174023" checksum="698F955F67DB5B60" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVM7</accession>
    <name>A0A0D2WVM7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inositol phospholipid synthesis protein Scs3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344266.1">
        <property type="nucleotide sequence ID" value="XM_004344216.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVM7"/>
    <dbReference type="FunCoup" id="A0A0D2WVM7">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVM7"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVM7"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVM7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="32818" checksum="BF2A8F22F036DC51" modified="2015-04-29" version="1">MAKGHQPHHAAAAHGKHHRHTTRRPQLWAASHVADGIHLPWVVVLQAIVVVFGSVLANLDAEHYFADKTNILNIMFVKRGWAWTVGLLVVFKLAVVLDGRQSWRHFSNVCARLAIATAGWWCVTTGLDTVRHWTGVCSDPLHETRRLCVHNGHRWDSLDLSGHTFLLAFSMLVIWEELRPHFELPFERATAAALATEASSSSPSESSSPNLNLNLNPNGASTSAETGTGRLSTPALWVLVALFVLWAFMLCTTALYFHTWVEKLVGLLLAQAIWFLQYPTFLQTHRYPGPPPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW22</accession>
    <name>A0A0D2WW22_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270700.1">
        <property type="nucleotide sequence ID" value="XM_011272398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW22"/>
    <dbReference type="STRING" id="595528.A0A0D2WW22"/>
    <dbReference type="InParanoid" id="A0A0D2WW22"/>
    <dbReference type="OrthoDB" id="2411356at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45710" checksum="BD78A61E697A8CEE" modified="2015-04-29" version="1">MSAAAPAAALAQQQPAFRRVFGFIGGAVAKAVSTTFIVLVVAAFVAQHVLDDKNTIAKTHSPEIVQARMLARFEAGSVIPPVRKSHIDRPEAVAMLQGVLRPALLKDYTVFIGEVGCGKTTAVLDAIRANSTGIVYYIVESELIVDVPKRLAGSLAFAFNRFTFTAGYFKDRGVEMEQVTSAEEPFKSWAILDLSLRDVAAQFKAKHGHVATLVIDAVDEIAKQGSELLHVIQKFAKSAADKQLLNVVLVTSDGSTLPELKASSAMTRARIVEVGDLTDQQAVTYLVRRDIHEDLAKRAVAEIAGGRLILLNNLADDLLFKSVDEIFEEFRVDTADSLQDVIDYSEMHNATSVVHKTLCELTHGALHIDIVHRALGKDLTKKLLATNINILAYHPNDTYTLHSRHVQRSVAALLNCTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW36</accession>
    <name>A0A0D2WW36_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343460.1">
        <property type="nucleotide sequence ID" value="XM_004343410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW36"/>
    <dbReference type="STRING" id="595528.A0A0D2WW36"/>
    <dbReference type="InParanoid" id="A0A0D2WW36"/>
    <dbReference type="OrthoDB" id="101791at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="771"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="855" mass="93916" checksum="0F9F8F0CC238EB33" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWE3</accession>
    <name>A0A0D2WWE3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mu-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWE3"/>
    <dbReference type="FunCoup" id="A0A0D2WWE3">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWE3"/>
    <dbReference type="InParanoid" id="A0A0D2WWE3"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWE3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="379" mass="39424" checksum="147DDFCB27E44FA6" modified="2015-04-29" version="1">MHGAASAIPFYTAETVQRVLQMPQLILAMEGALRAFSGGRVTQPVRSTVGAHEGFLALMPAFVHPSDHHQHSSTPASSGSSQAHALSSSSSSSASSGALGVKLVTFYPHNPRGVATHSAVIALFEPTTGIPTALMDGSVITELRTAAVSAVAARLLAPLDSSVLCILGSGAQAWSHWQAMRLVRPFTHVRIWSRTPANAHALADRITRQQASQTAHSSSSENPSPVQVTVASTPRDAALGADVIVCATSATEPILLGEYVKPGAMVTAVGACRPNWREMDDALMQNSIVIADSLAGALKESGDIILSQATVAGELGELLTRRDEIARAQNATSTLNTLASSNAYLPLQTSPVKPIVFKSLGMAVEDVVAASLVVGALHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWT6</accession>
    <name>A0A0D2WWT6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343410.1">
        <property type="nucleotide sequence ID" value="XM_004343360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWT6"/>
    <dbReference type="STRING" id="595528.A0A0D2WWT6"/>
    <dbReference type="InParanoid" id="A0A0D2WWT6"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="303"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="927" mass="101169" checksum="DA3C03C5E5DA13A4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXG3</accession>
    <name>A0A0D2WXG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343047.1">
        <property type="nucleotide sequence ID" value="XM_004342997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXG3"/>
    <dbReference type="STRING" id="595528.A0A0D2WXG3"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXG3"/>
    <dbReference type="OMA" id="ANEMFIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="17458" checksum="15B11C9284F05499" modified="2015-04-29" version="1">MSSTPKIARKGTMAATAEAGKDFIRRENAAKRGKAAGTTSTKTRSSRAGLQFPVGRLERFLRSGAYARRIGGGAPVYLAAVLEYLTAEILELAGNAARDNKKTRINPRHIQLAVRNDEELNKLLANVTIAQGGVLPNIHAVLLPRKDDGSKYDEEVEDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXU8</accession>
    <name>A0A0D2WXU8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zuotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342742.1">
        <property type="nucleotide sequence ID" value="XM_004342693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXU8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXU8"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXU8"/>
    <dbReference type="OMA" id="SFWYDFD"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXU8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="585"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="651" mass="72676" checksum="6D214B9802242B5A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY19</accession>
    <name>A0A0D2WY19_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342935.1">
        <property type="nucleotide sequence ID" value="XM_004342886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY19"/>
    <dbReference type="eggNOG" id="ENOG502RVFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY19"/>
    <dbReference type="OMA" id="KWSSANQ"/>
    <dbReference type="OrthoDB" id="19798at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="157"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="690" mass="73303" checksum="497BD06C96B222B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYW4</accession>
    <name>A0A0D2WYW4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_010202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346380">
        <property type="protein sequence ID" value="KJE98298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYW4"/>
    <dbReference type="STRING" id="595528.A0A0D2WYW4"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYW4"/>
    <dbReference type="OrthoDB" id="2020019at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYW4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254771" description="BZIP domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="739"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE98298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="798" mass="82229" checksum="72B145EE2856A219" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ18</accession>
    <name>A0A0D2WZ18_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346426">
        <property type="protein sequence ID" value="KJE98433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004340389.1">
        <property type="nucleotide sequence ID" value="XM_004340341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ18"/>
    <dbReference type="STRING" id="595528.A0A0D2WZ18"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WZ18"/>
    <dbReference type="OMA" id="MVESEFM"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WZ18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE98433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="138" mass="15368" checksum="AEA2400164772D8A" modified="2015-04-29" version="1">MIRWFCILTGKYSQGKFPEGSRLSLESLAWLKDRKLAAENKWQFEAADKLLPIAEELGCSLAQLSIAWCAKNPHVSTVILGATSLKQLEENFKALEVVPKITPELIKRIDEIIGNKPKLTAVEAQVRNLLNVDALGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X080</accession>
    <name>A0A0D2X080_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-methylacyl-CoA racemase</fullName>
            <ecNumber evidence="7">5.1.99.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-methylacyl-CoA racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters. Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40455"/>
            <dbReference type="ChEBI" id="CHEBI:58677"/>
            <dbReference type="ChEBI" id="CHEBI:77251"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:40456"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:40457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46732"/>
            <dbReference type="ChEBI" id="CHEBI:86982"/>
            <dbReference type="ChEBI" id="CHEBI:86983"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:46733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:12657"/>
            <dbReference type="ChEBI" id="CHEBI:57313"/>
            <dbReference type="ChEBI" id="CHEBI:57314"/>
            <dbReference type="EC" id="5.1.99.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:12658"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:12659"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.4" evidence="7"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X080"/>
    <dbReference type="STRING" id="595528.A0A0D2X080"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X080"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X080"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000004">
        <property type="entry name" value="Probable alpha-methylacyl-CoA racemase mcr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10540:FF:000004">
        <property type="entry name" value="Probable alpha-methylacyl-CoA racemase mcr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="439" mass="47473" checksum="3543BC2EF1178FB3" modified="2015-04-29" version="1">MQRANRVWMHGFGHWCLPFIHSCPPGVHFTRLAAIALPFVSLCYCWACISGYWEKMALRGLKVIEMAGLAPAPFAGLVLADFGANVIRVDKLADFSVDRLSRGKQSVSIDLKSPRGAQAVRDLCKNADVLIEPFRPGVMERLGLGPDDLLKTNPRLIYARLTGYGQTGKLAQRAGHDINYVAVSGVLSALGRRHENPAFPGNLVGDFAGGSLMCVIGILTALQERARSGKGQVIDAAMVDGASYLASFVYGVRETGMWDGPRGTNLLDGGAPFYETYKTKDGKYMAVGSIEPQFYRLLLQGLGLDGDSTLPEQLDKEGWPQLKERFTQIFASKSQAEWCAIFDHTDACVTPVNELDDPLTDANSHGASRGILYRSEEGVMPVPAPRLSREGALDVQNLTMPRVGQHTVQALTEAGISPADVAKLLKDGIINDASGAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Q8</accession>
    <name>A0A0D2X0Q8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365817.2">
        <property type="nucleotide sequence ID" value="XM_004365760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0Q8"/>
    <dbReference type="InParanoid" id="A0A0D2X0Q8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="653" mass="70917" checksum="49559E308E0D8F8D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1H6</accession>
    <name>A0A0D2X1H6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348817.1">
        <property type="nucleotide sequence ID" value="XM_004348767.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1H6"/>
    <dbReference type="STRING" id="595528.A0A0D2X1H6"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1H6"/>
    <dbReference type="OMA" id="KKSCVFG"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1H6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22306" checksum="D8CF03B3064B3329" modified="2015-04-29" version="1">MSGDGKYHVHYFAGRGLGEIARIALSEAGVEFEDHRFESLPADLKATTKFGQVPLLVTPAGDRINQSTAILRFIGATHGLSGKTALENAEIDQVIEGVNDIRAKYRALPADAANEERIKFFSTVLPQWLGYFEAILKKTGSGFYVGSNVTIADLYVYVSFDSVINKTADAQPIDAFPLVKAHLEAIAARPRIAAWIAKRPVSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2N6</accession>
    <name>A0A0D2X2N6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nudix hydrolase 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363492.1">
        <property type="nucleotide sequence ID" value="XM_004363435.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2N6"/>
    <dbReference type="FunCoup" id="A0A0D2X2N6">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2N6"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2N6"/>
    <dbReference type="OMA" id="GMRDETD"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="255" mass="28142" checksum="B421B5E1A9123342" modified="2015-04-29" version="1">MQAPDVDVILERLRHYIPEHPQESLSSSLRALPTAAVLVGLFYCETTHSVRVLLTKRAVDMRSHGGEVAFPGGKRDDTDRDAAHTALREAEEEVGLPQTWPQVIKAMAPFVSKNLLLVTPVVAWLGNRSQLPRLTPNPREVSVIFDAPFDMFALGLHHSFMDISFRSVPFRIHFFDYPIDALSLLATSDKVDPTLTSSANIFGLTALVLIVASKVAYEHTPSFSLMPPGGLLPTQLELDGDRFVLPATHQPSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2R9</accession>
    <name>A0A0D2X2R9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2R9"/>
    <dbReference type="STRING" id="595528.A0A0D2X2R9"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2R9"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2R9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="624"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="963" mass="106622" checksum="4822EE9198BA91E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T9</accession>
    <name>A0A0D2X2T9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270376.1">
        <property type="nucleotide sequence ID" value="XM_011272074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2T9"/>
    <dbReference type="FunCoup" id="A0A0D2X2T9">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2T9"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T9"/>
    <dbReference type="OMA" id="AFKGWRK"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17347">
        <property type="entry name" value="MFS_SLC15A1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000049">
        <property type="entry name" value="Solute carrier family 15 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="808" mass="86739" checksum="83AB46D245682FCC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X306</accession>
    <name>A0A0D2X306_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348086.2">
        <property type="nucleotide sequence ID" value="XM_004348036.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X306"/>
    <dbReference type="STRING" id="595528.A0A0D2X306"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X306"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X306"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="58030" checksum="8E5BEBCC40D29FAB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3B0</accession>
    <name>A0A0D2X3B0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270446.1">
        <property type="nucleotide sequence ID" value="XM_011272144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3B0"/>
    <dbReference type="STRING" id="595528.A0A0D2X3B0"/>
    <dbReference type="eggNOG" id="ENOG502S5S2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3B0"/>
    <dbReference type="OMA" id="IPQENYY"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3B0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="151"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="389" mass="42069" checksum="281EF7B7B329A7FC" modified="2015-04-29" version="1">MSVGRVLIASVVLSAQLELARRAVVALSRDPALALGLLSLAAWGSRTLPGTALLQAIAAPLGAVLAPIRARFSPSTEPDASRPASAMDRRLMFDMYDIQSSKRALLNLRPPTETWMNFGLWPSASALPPSYGLREACEALATLLAHTVELNSQDTLLDVGCGCGDQDVLFAKTFQPKSILGVEIAPSQVAQAQCHIQRHGLESNVQVVQGSAVDLAASCRAARQFSVVLSLDSAYHYALRRDFVHEAFRVLQPTGRLGLVDICVTDSWQETLCSPAFSARLSQIMFRLGCKAAAIPLANMVSQTEYASQLSAAGFEDVHIRDISDQVFEGFARHIETTAEQLASVTRPLDWIGFRLAARLMRFLGNKRVVKFIVVKSVKPATRSGLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3G3</accession>
    <name>A0A0D2X3G3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347678.2">
        <property type="nucleotide sequence ID" value="XM_004347628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3G3"/>
    <dbReference type="STRING" id="595528.A0A0D2X3G3"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3G3"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3G3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF92">
        <property type="entry name" value="CIN85 AND CD2AP RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="474"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="692"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="749" mass="81280" checksum="010A6542A9B7A6C0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X455</accession>
    <name>A0A0D2X455_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X455"/>
    <dbReference type="FunCoup" id="A0A0D2X455">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X455"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X455"/>
    <dbReference type="OMA" id="MTIANAN"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X455"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="228" mass="25317" checksum="9177A78987AA3712" modified="2015-04-29" version="1">MTIANANALLSKLRGEWTATKPNHQLCGDLLIQLKIALTELSFLPTAGVQSAEELLLAREVLEIGALHSIAVGDFAAFDRYAVQLRTYYFDYAAAIPTSSQRSLLLGLHLLRLLSQQQIGDFHVALERLNSVTLTSDPFVRFPIALEQHIMEGLDHQVFAAVQNVPHPSYVPFMEQLLQTLRSNAESDKLKLSVGDARKLAAKIELHDYSAQVIQNALGYAKELERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X458</accession>
    <name>A0A0D2X458_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345523.1">
        <property type="nucleotide sequence ID" value="XM_004345473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X458"/>
    <dbReference type="STRING" id="595528.A0A0D2X458"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X458"/>
    <dbReference type="OMA" id="FRRIQYT"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X458"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="136" mass="15177" checksum="01904D2172F5D163" modified="2015-04-29" version="1">MQIFVKTLTGKTITLDVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGKVHGSLARAGKVRGQTPKIEKTEKKKSPTGRAKRRLQYNRRFVLALVKGKKGPNTQNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X460</accession>
    <name>A0A0D2X460_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345533.2">
        <property type="nucleotide sequence ID" value="XM_004345483.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X460"/>
    <dbReference type="STRING" id="595528.A0A0D2X460"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X460"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X460"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="490"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="794"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="834"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="947"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="979"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117927" checksum="EB3E5D4B154DBF17" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A7</accession>
    <name>A0A0D2X4A7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345741.1">
        <property type="nucleotide sequence ID" value="XM_004345691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4A7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4A7"/>
    <dbReference type="eggNOG" id="ENOG502QU2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4A7"/>
    <dbReference type="OMA" id="GWASWHA"/>
    <dbReference type="OrthoDB" id="2020799at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009199">
        <property type="entry name" value="PhoPQ-act_pathogen-rel_PqaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31497">
        <property type="entry name" value="AUTOCRINE PROLIFERATION REPRESSOR PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31497:SF0">
        <property type="entry name" value="AUTOCRINE PROLIFERATION REPRESSOR PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10142">
        <property type="entry name" value="PhoPQ_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014728">
        <property type="entry name" value="PqaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254873" evidence="1">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="496" mass="54620" checksum="1A22AF7A3DCD9409" modified="2015-04-29" version="1">MVSRVTALAVTVALAAIVAVAAATPLDDYVNKPDSTYAYKLVNQVKGPDYVTYNIFMTSQTWLTANDTNKPVWTHWLQVCVPDYPVHTTLGLLYIDGGGSANENGNAPDPDALVSIICGTSRVVAAHLTSIPNEPIVFTSDPTQASRSEDAIIAFTWEHFIFNKNDSFWLAHLPMTKASVRALDTMTSFVGSLGGKAIAPTQFIVAGASKRGWTTWLTGAVDKRVVGIVPIVSPFGNLVPQMNTMFQAYGNFSFALDDYMNAGCIHYLNTQSFVDLLAALDPLNYADRLVMPKLIVCDTGDEFFLPDSIDYMWSGLKGEKLFRVVPNAEHSLTGHQLEVADQVLSFVETMIYNHPRPQADWEISADGTTITYRHLSPQVLPTKVVMYHNHHPGPARDFRIIKCANFKDPKCIDVRLWLSQELVDQGNGVYIAQQVAPQVGYTGFFIEAEYNISLIALVDPFKVTSGVSILPQTLPYPPCGSNCAWPDPTADVERFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4M6</accession>
    <name>A0A0D2X4M6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4M6"/>
    <dbReference type="FunCoup" id="A0A0D2X4M6">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4M6"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4M6"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="43438" checksum="13FF07B5A3DC2A95" modified="2015-04-29" version="1">MATSVPLVKIDTEYSADAVEWCPTSAEPLLACATYQLAAAEQEPEPEPEKSSTTTTTTQEDSDDETEKRTPPRARLGRLLLYRLETGAAAAADGETTTLRDAGLNSSNIRLVEVLRRDMPAILDIKWLPRTIANSDPVLAIVDASGFLTLYRVGMSAKSVTLEVLCQSNAVSDTLRLSLEWNCRIDASSPLQIASSDSAGQIALHQFAEGEVALVQEWEAHSFEAWITAFNQWNTSTVYSGGDDSLFRGWDTRTDCTTPIFTSKRHTMGVCSLQSHPSREHILASGSYDEHIRLWDTRSMRAPVEDIRVHGGVWRLKWQAQNPSLIAAAAMHGGVPVVSVDESNKPSLTHRHTAHESIAYGVDWHPQIEGLIASCSFYDHSLHLWRLPTNADMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4S2</accession>
    <name>A0A0D2X4S2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4S2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4S2"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4S2"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4S2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="37648" checksum="66DDFA9F82B49943" modified="2015-04-29" version="1">MFKKSSQSRPSNLRRRDGDEDEPATAVPSTAAAAAERRVRSQVDDGANDSDEDPSKLKTATKQPAADDADDSDDDASSDDDGEDGDDRKAGHVAKRARLVTTGLDAGTSSTLSAASSSDGSKLATPFEAGRQSLEQRNGGPRMYNEADPVLRKGEATSTGLRGFRAAPMKAAANIRTTVRFDYQMDVCKDYKETGFCGFGDTCKFMHDRGDYKTGWQLDKEWDEHKKAADSKPKTGAKEVFTRDDDLPFACHICRGDFVNPVVTRCKHYFCEKCALEHAKKSSLCAVCQSATNGMFNRAKDLADALKRRQKRQDDSSQKEHEQAMRRSAGNGIANDDEDEIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X599</accession>
    <name>A0A0D2X599_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Squalene monooxygenase</fullName>
            <ecNumber evidence="13">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007297</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="13"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343156.1">
        <property type="nucleotide sequence ID" value="XM_004343106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X599"/>
    <dbReference type="FunCoup" id="A0A0D2X599">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X599"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X599"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="15">
        <location>
            <begin position="227"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="57611" checksum="5E843839BA49A622" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5A4</accession>
    <name>A0A0D2X5A4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="14">ETF-QO</shortName>
            <ecNumber evidence="14">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_007319</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="14"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343178.1">
        <property type="nucleotide sequence ID" value="XM_004343128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5A4"/>
    <dbReference type="FunCoup" id="A0A0D2X5A4">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5A4"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5A4"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5A4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000012">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="12 14 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ETF-QO/FixC ubiquinone-binding" evidence="16">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ETF-QO/FixX C-terminal" evidence="15">
        <location>
            <begin position="538"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE97464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="642" mass="69583" checksum="43B1F8D934ABBCA6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5A8</accession>
    <name>A0A0D2X5A8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5A8"/>
    <dbReference type="InParanoid" id="A0A0D2X5A8"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5A8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="309" mass="34810" checksum="4A0DBD5D1FA56AC0" modified="2015-04-29" version="1">MAPGSKQTHNVLIVLLLVCNIATVVLLRPWDTQQAEQSVHQDTIASLETELQDTRRQLEQLVQSISLQDAIDVPCTQLASPPENPVQADLELPELAERFQDLARVVGVFASDFAPAPLPAVTSRIFVTMAGHLRSQALNLANFESWVEPMRAQGAQIFLAEYLWSDLDAPQDSWWKKNGSALVKEQTLIHGKPVDILAKQIEPALRRLQIPYVTVVSDQQAERGVFHSHRARSWVGVHRAMHLLPRMPNSGRFTVAPADIVMSTRPDVLYERSFAVRPLVAFLKRNPMTVFVMSFYHDPTKTVRFFFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5B1</accession>
    <name>A0A0D2X5B1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5B1"/>
    <dbReference type="InParanoid" id="A0A0D2X5B1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="121" mass="13749" checksum="91298612A7022F4F" modified="2015-04-29" version="1">MSLQRQRGDSSESSRAMHQRLNRMSRGTRRCICSMGRRLMTSNRRVSRSLLQWRSIGMALTCAAALRTRAGLVAQSVRFDMETLKAGRHGPQRKGKPADQESKANATHLQDRTKTDFRSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5C4</accession>
    <name>A0A0D2X5C4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007401</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343260.1">
        <property type="nucleotide sequence ID" value="XM_004343210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5C4"/>
    <dbReference type="FunCoup" id="A0A0D2X5C4">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5C4"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5C4"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5C4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266828" description="Mitochondrial inner membrane protease subunit" evidence="12">
        <location>
            <begin position="35"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="167" mass="18662" checksum="6C135042838A476A" modified="2015-04-29" version="1">MKSFLKAFAVRSLVILPLAITLTDSVASVAGVQGRSMQPTLNPDIAVDHILLDKWSVRDHRHRRGEVVVLWSPDEPTVAVIKRIIALEGDVVKTLSYKDPFVKIPRGHCWVEGDNHIHSRDSNTFGPIPVALIDARATHVIWPPARIQKIETVVSPDRIERYGRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I5</accession>
    <name>A0A0D2X5I5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343036.1">
        <property type="nucleotide sequence ID" value="XM_004342986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I5"/>
    <dbReference type="STRING" id="595528.A0A0D2X5I5"/>
    <dbReference type="InParanoid" id="A0A0D2X5I5"/>
    <dbReference type="OMA" id="MPCHGLR"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18462" checksum="613C75BB7A762744" modified="2015-04-29" version="1">MLPNLIPISTFEDVDTAISAKDKLQGYEHNGRRLDLDFAEGERKTSRTMASNDPRGGRRRGRSRSRDRRGRSRSRSPVRRYSRSRSPVRRRSRSPVRRRSRSRSPVRRRSRSRSPVRRRSRSRSPDRSARRRSPSRSRSRSRSPARRPMSRSPSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0A7</accession>
    <name>A0A0D2U0A7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365107.1">
        <property type="nucleotide sequence ID" value="XM_004365050.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0A7"/>
    <dbReference type="InParanoid" id="A0A0D2U0A7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="528" mass="56829" checksum="E397D33EC7E93F28" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0D8</accession>
    <name>A0A0D2U0D8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0D8"/>
    <dbReference type="STRING" id="595528.A0A0D2U0D8"/>
    <dbReference type="ESTHER" id="capo3-e9byc7">
        <property type="family name" value="NLS3-Tex30"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0D8"/>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0D8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046879">
        <property type="entry name" value="KANL3/Tex30_Abhydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20408">
        <property type="entry name" value="Abhydrolase_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL3/Tex30 alpha/beta hydrolase-like" evidence="3">
        <location>
            <begin position="313"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="776" mass="83468" checksum="12A64CAD5C6C2DD9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2P5</accession>
    <name>A0A0D2U2P5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365801.2">
        <property type="nucleotide sequence ID" value="XM_004365744.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2P5"/>
    <dbReference type="FunCoup" id="A0A0D2U2P5">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U2P5"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2P5"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000073">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000003">
        <property type="entry name" value="DNA damage-binding protein 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="38"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="410"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="803"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126199" checksum="D36D75BFABE28384" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U387</accession>
    <name>A0A0D2U387_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRCA1 associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365927.2">
        <property type="nucleotide sequence ID" value="XM_004365870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U387"/>
    <dbReference type="FunCoup" id="A0A0D2U387">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U387"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U387"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U387"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12437">
        <property type="entry name" value="RRM_BRAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="518"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="728"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="894" mass="96442" checksum="B8B82EB74C39FBF4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4K6</accession>
    <name>A0A0D2U4K6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neutral ceramidase</fullName>
            <ecNumber evidence="2">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364319.1">
        <property type="nucleotide sequence ID" value="XM_004364262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4K6"/>
    <dbReference type="STRING" id="595528.A0A0D2U4K6"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4K6"/>
    <dbReference type="OMA" id="NNHMGYF"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4K6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265417" description="Neutral ceramidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="472" mass="49703" checksum="0B53C13A01BA23D9" modified="2015-04-29" version="1">MTRTAAALLLVLACATAAALANPLHDAFSAPAGSVRAGVSKVDATMPIGVPLGGYNHGERRVPNWPLPIRTNYTYWMTPSVGHLDPTWAKALVIDDGNTKFCFATIDAIGSEGDLRKMAYDNAVSRGFTVPYGQFILSASHTHSGPAGISSSFLFEAAPAMDLKVAALQELMASHIADALVQAEQNLAPAQFGIGVGQLVGVTRNRRANISPYVTPTSIDPNLGVVRVDDQNGKPIATVFNYAMHGTCYGPSNMNSSGDIPGASCNAVEQAIGGVALFVNADAGDIDPTGESCQNFAGAVTIAQAVKSTRDSIVTATNITIAAAYAEVNFGDTDMNITLARFENCTSGGELDICTICAVIGCEYNAHLGPFYIETVPAFAGVRFTVNNVHTLLATLPGEPLLELGWQVRNDSAALGFDQMILAGYTNNHMGYFCTPNEYVIGGYESQLTLWGIDTAEKIRASVKQVAAQVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9C6</accession>
    <name>A0A0D2U9C6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9C6"/>
    <dbReference type="FunCoup" id="A0A0D2U9C6">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U9C6"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9C6"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9C6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="57"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="308"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="710" mass="77456" checksum="6AA3BB00C634BF26" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9D7</accession>
    <name>A0A0D2U9D7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_002769</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349522.2">
        <property type="nucleotide sequence ID" value="XM_004349472.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U9D7"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9D7"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9D7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="832"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="20">
        <location>
            <begin position="1487"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="490"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="688"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1358"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1459"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1564"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1694"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1358"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1381"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1416"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1577"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1694"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1749"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1762"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE91661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1771" mass="188070" checksum="5CA467A45D29D5E0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9K9</accession>
    <name>A0A0D2U9K9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363695.1">
        <property type="nucleotide sequence ID" value="XM_004363638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9K9"/>
    <dbReference type="STRING" id="595528.A0A0D2U9K9"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9K9"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="261" mass="28355" checksum="1A8DCB74EDFD5C9D" modified="2015-04-29" version="1">MSLQLKSLVRKELRARLRAMDTATRAAESKRIVTQVLTQCERYKQAKHVAMFLSMPSEVDTAELLADSLKAGKTVYVPRYEADTMDFLRVYSLRDIATLPRNEMNIAQPEYHVSQSVLTPEATEVEMASPAEAAGGASVTTTSETTAPTTAPTTATTAHSNTTTTNTTPSIKESAETVARENPLDNGKLDLILVPGLGFTAAGDRIGRGKGYYDKYLTRIFTTFAANGWTAPATIALTFPCQIMDSIPTDATDVRIGHVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAS5</accession>
    <name>A0A0D2UAS5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363967.2">
        <property type="nucleotide sequence ID" value="XM_004363910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAS5"/>
    <dbReference type="STRING" id="595528.A0A0D2UAS5"/>
    <dbReference type="eggNOG" id="ENOG502SGMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAS5"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218:SF3">
        <property type="entry name" value="OS07G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="406" mass="45884" checksum="C3BF85CC9B950123" modified="2015-04-29" version="1">MNEHSNEADSDSVQRAHAETRNDDDDGDDGDDTSGLTNASAAAAATHAHRSRLLHYFRSHDGEDIEQDGDDEDDDDDDDGDDEEEEEDQDQEDQQDEAADQQQQLEDDDFGVDADDEEEDRFVRMLLEQENRRDMFRWSSSDEESMSDYEVEIAGGIRMVIALRRPRGHSAPVPPTHAAAELASSSSSSALLATSSAAAEGDVGDATAADFTTILPLEILEFILSFLDPVDLHRAGQVSRFWHQIADADTLWKPACHRLWKGKFGMSLTSSDPPRCMAREEFAGLQELDICRFKKYYFATLADSKRTVISFDEVVDSQWDLRFRSHLHVAHNTNPRFFRNGTFRSNMHRESMVWRFVDNTHTIQVAHFPPLVPSRSTIDWSFKLKNPWVIIRTLDANSMASAKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAT9</accession>
    <name>A0A0D2UAT9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAT9"/>
    <dbReference type="InParanoid" id="A0A0D2UAT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="146" mass="16564" checksum="AFC9DF281A1C2A15" modified="2015-04-29" version="1">MGWLDRLLLVFEAVMTLFVIVIRIFYPFSFLFGSCFAAIRLHSDCKATTAQCGQTQANSHHDIERDPFKGTGVDGRNCSAFSNFQKSSVLLLCPSLYYIAHDTPLYIEWQSSLVCTLLNSLLTVFVLFFAFLFICLFLFLFLGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBL4</accession>
    <name>A0A0D2UBL4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364242.1">
        <property type="nucleotide sequence ID" value="XM_004364185.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBL4"/>
    <dbReference type="InParanoid" id="A0A0D2UBL4"/>
    <dbReference type="OrthoDB" id="3213154at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="192" mass="21072" checksum="064CD083E7B12BF0" modified="2015-04-29" version="1">MPPKAAPPAAAEPLAAAEPHAEESHDTEPDWSTLSASNVFSESFLEYNRGRESHLRDLMRKSKDLGKEVDALKTQHTSTQEALRHFRALRDDLTAGTDRLERGAKAAQQEIYTKLKRFSEHGIQGEPGTPAFMENLVKALKAGALSPEVLSDLREAIKSLDLSLFDSAKIISEGQQSQPPSTDEPAPMQVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGL7</accession>
    <name>A0A0D2UGL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347653.2">
        <property type="nucleotide sequence ID" value="XM_004347603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGL7"/>
    <dbReference type="STRING" id="595528.A0A0D2UGL7"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGL7"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="822" mass="87699" checksum="5346208785C13FE4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK16</accession>
    <name>A0A0D2UK16_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK16"/>
    <dbReference type="InParanoid" id="A0A0D2UK16"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="66" mass="7379" checksum="F73F9FFD13C59981" modified="2015-04-29" version="1">MTDEDNNNTFENTLARPSLASRVPAFEYAKCVNAWAGHHDYSAFDHSVILGAHPNLELFGLFLNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULZ2</accession>
    <name>A0A0D2ULZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345209.1">
        <property type="nucleotide sequence ID" value="XM_004345159.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULZ2"/>
    <dbReference type="STRING" id="595528.A0A0D2ULZ2"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULZ2"/>
    <dbReference type="OMA" id="VHKSCMK"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF48">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="350"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="521"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="648"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="711" mass="71816" checksum="06253F0E693ABBF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMJ9</accession>
    <name>A0A0D2UMJ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344240.1">
        <property type="nucleotide sequence ID" value="XM_004344190.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMJ9"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMJ9"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53086" checksum="73A04EA4AAAC9AEE" modified="2015-04-29" version="1">MLSYDDMTERQREVYDYVKNEVVLMLSGARMNEAEAQAVVEGLKVNTKLIFLSLSTNPIAAVTIADLLRVNKTIQNLFLQENQIGDADAVAIADALKVNTTLNDLDLKVNQIGDAGAVAIADALKLNMTLKKLRLDENQIGDAGAVAIANALKLNTTLARLLLVENQIGKAGAQAIAEALTVNTTVTELRLDKNQIGDAGAQAIAEALKVNTTLTELRLHQTQIGDVGAQAIAEALKVNTTLIDLQLSGNQIGDIGAQAIAEALKGNPTGITVDLNSNCIDRAFVQLVKQAQKTKNRGLYLSNDTQFNPLVFSLLPRLASTEDIQAVLGMLTSGLELENQSQSLPALPTEIAELIMDEAYYWQGVQHAKRMHGDQHYTLTVTVPRSVIGNSIRVKTIQVLREWKLCPDTISDCVFDLTVQDEQGAVRYECLVQPTFVDSNLLQLATIWPANHPILRQMREGWQVRVARSKSNEYVRFEALYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPR2</accession>
    <name>A0A0D2UPR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343350.2">
        <property type="nucleotide sequence ID" value="XM_004343300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPR2"/>
    <dbReference type="STRING" id="595528.A0A0D2UPR2"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPR2"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50070" checksum="2846B5D628CDB184" modified="2015-04-29" version="1">MQSKTERQRELYDKFKNANGGLYLSENQIGDAEAQIIAEALKVNTTATSLDLSENQIGDAGAQAIAEALKVNKTLFWLNLHQNQIGDAGAHAIAEALRVNKTLKELSLAQNQIGDAGAQAIAEALKVNKTLTLLNLIVNQIGDAGARAIVDTLKVNETVTSLHLHDNLIGDAGAQAIADALKVNKTLSWLNLIDNQIGDAGAQAIAEALKVNKMVKTLSLSENQIGDIGAQAIAEALMVNKQLWWLDLKCNCIGDAGFQAIGEARQVNRTLAHLLIDKQINPLAFSLLPRMSTAEDLHDVFHLLTSEPAVEDQSAALPALPTEIAELILDEAHYWQGVQHTKRQWFQYHSPECILKVTLPQGVNGNAIRVKEIHVLRGNRSDSVNDTGFELIVQDEQGAVRYECSVKPTLVDSSLELVTIVPASHLVIRQMRAGWQVQVRPSKFHYNVVFESLYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQL0</accession>
    <name>A0A0D2UQL0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQL0"/>
    <dbReference type="eggNOG" id="KOG4744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQL0"/>
    <dbReference type="OrthoDB" id="6363407at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="800" mass="89323" checksum="EA4E6FAF3A850ADF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR85</accession>
    <name>A0A0D2UR85_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR85"/>
    <dbReference type="InParanoid" id="A0A0D2UR85"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="118" mass="13602" checksum="16E3EEF74461C45A" modified="2015-04-29" version="1">MTILQRYHLPMPVKLLCLVHYTFLIQLLANSTLIFIVLPVCQAILSSPTSDVASLVDASLAFHHQLEFWIFIQFIPRRTLLHPFPLDFLCVYRSIDLNKKKKVETQTCVHVDLACHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URW9</accession>
    <name>A0A0D2URW9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URW9"/>
    <dbReference type="FunCoup" id="A0A0D2URW9">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2URW9"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URW9"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="553" mass="61878" checksum="9381F9EA93A13811" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USA6</accession>
    <name>A0A0D2USA6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343020.1">
        <property type="nucleotide sequence ID" value="XM_004342970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USA6"/>
    <dbReference type="STRING" id="595528.A0A0D2USA6"/>
    <dbReference type="eggNOG" id="KOG3845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USA6"/>
    <dbReference type="OMA" id="VCITCCD"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USA6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="7">
        <location>
            <begin position="87"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="380"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63911" checksum="A7A9E543E52E0DCC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USR5</accession>
    <name>A0A0D2USR5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342661.1">
        <property type="nucleotide sequence ID" value="XM_004342612.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USR5"/>
    <dbReference type="STRING" id="595528.A0A0D2USR5"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USR5"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USR5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="633"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="866" mass="91693" checksum="4E6FC8D6FF792F07" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTK3</accession>
    <name>A0A0D2UTK3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar ATPase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346385">
        <property type="protein sequence ID" value="KJE98316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341958.1">
        <property type="nucleotide sequence ID" value="XM_004341910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTK3"/>
    <dbReference type="FunCoup" id="A0A0D2UTK3">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UTK3"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTK3"/>
    <dbReference type="OMA" id="LPCFEHF"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTK3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE98316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="35652" checksum="1521BE85677FA421" modified="2015-04-29" version="1">MSGKDRIPIFPTRMALTTMKNRLKGAQKGHSLLKKKADALSLRFRSILGAIIRSKESMGEVMRLASFSLAEAKFVAGDFSHGVIESAKVAKVRVRTKTDNVAGVKLPVFEQYMDSVGSTFELAGLSKGGQHIARTRLNYIEAIKLLVEIASLQTTFITLDEVIKITNRRVNAIEHVIIPRIENTISYINSELDEMDREEFFRLKKIQKKKKASRAASEAKAALANAATKLAEDQAAQAAFAQSSAGAPAPAKPAKGKKGDKAAAAAAAPAPNYDIPEALREAATAPTNPFETDAPADTSAADTGMMSNPFITPEAHAGQDIVSQQDQDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTP1</accession>
    <name>A0A0D2UTP1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346397">
        <property type="protein sequence ID" value="KJE98356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTP1"/>
    <dbReference type="InParanoid" id="A0A0D2UTP1"/>
    <dbReference type="OrthoDB" id="2429079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="596" mass="66385" checksum="C454867445DFBAF1" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH12</accession>
    <name>A0A0D2VH12_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_000726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365597.1">
        <property type="nucleotide sequence ID" value="XM_004365540.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH12"/>
    <dbReference type="STRING" id="595528.A0A0D2VH12"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH12"/>
    <dbReference type="OMA" id="AHAQYMV"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="291"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="493"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE89207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="680" mass="76277" checksum="EF2DD7D7BE301796" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH41</accession>
    <name>A0A0D2VH41_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365628.1">
        <property type="nucleotide sequence ID" value="XM_004365571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH41"/>
    <dbReference type="STRING" id="595528.A0A0D2VH41"/>
    <dbReference type="eggNOG" id="KOG3294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VH41"/>
    <dbReference type="OMA" id="PYPGINA"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VH41"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="35623" checksum="6673529129DD3B31" modified="2015-04-29" version="1">MALNAAFLQNGGIVTLPGEQFAFDRGGIEFSVTGSPGGSSQGAPAGSNTTVGYNGKGHIFLSNFRIVFLNQPVVHNFESFVLPLPHIYDATLKQPIFGANFFAGFVNPLPEGGLSGKVEFKIYFKEGGATDFATRFLAVARTTTRERAPGPGGPPSYYAAASLHGGGIGPGLRAAGAPVGAAGMGMGLGPGIGLGMRMGMNTRPVQATSRPPPSSSSSSQSGVHQPAGGPSAPPPTPNQKAVEAGVPQYQTEQQRVYGAHPHPYQSQPQPYQPYPPYPASYPQQQHPQQPPLPYPAQHLPYPTTNQQPQQQPVPPAPAHAAPTPSAASQIRPDDLPPPYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHN9</accession>
    <name>A0A0D2VHN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365797.2">
        <property type="nucleotide sequence ID" value="XM_004365740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHN9"/>
    <dbReference type="FunCoup" id="A0A0D2VHN9">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VHN9"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHN9"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="710" mass="77754" checksum="15F96D9BE00BCCE9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJW8</accession>
    <name>A0A0D2VJW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MSH5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJW8"/>
    <dbReference type="STRING" id="595528.A0A0D2VJW8"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJW8"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112542" checksum="56AC8C8C43382CD6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKH4</accession>
    <name>A0A0D2VKH4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKH4"/>
    <dbReference type="STRING" id="595528.A0A0D2VKH4"/>
    <dbReference type="InParanoid" id="A0A0D2VKH4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKH4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17952">
        <property type="entry name" value="DEADc_DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="321"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="524"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="909" mass="98320" checksum="72F519EE1284FC7B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL45</accession>
    <name>A0A0D2VL45_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL45"/>
    <dbReference type="InParanoid" id="A0A0D2VL45"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="147" mass="15766" checksum="193054C366BF3715" modified="2015-04-29" version="1">MLVGKPHKVWWYRQGAAALMGGGGSRGTSLWGAGAGTGRRCGSTTEQLKAERLPQQRGGILLASHAQKTMHFDRNHVRHRVTSGVAVRDGSQSAVKVVVLDERVADQRSAFARREPGEGVWQIAGLDADQRRAPANCLLGSQLSEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL60</accession>
    <name>A0A0D2VL60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348834.2">
        <property type="nucleotide sequence ID" value="XM_004348784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL60"/>
    <dbReference type="STRING" id="595528.A0A0D2VL60"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL60"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VL60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00682">
        <property type="entry name" value="HscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="346" mass="38045" checksum="7DB57B32C917D232" modified="2015-04-29" version="1">MLLQLLKSRPPPLSTLANSIPFASSLASSSSSSSSSLSLTVPSMRSTATAATRAMQTRAAAAIASSRDCHCSPAARASSCYYTQAPSIQPHYALTRAERRRSACSASTRDFHLHAPSVASTSGQPGQTTARQAAGDASKTPSKSNGHSCWSCPGLLAKNDLFCHSCSVIAPPALSGTYFDLFGLPVSFDLDTANLERLFRQLQWKLHPDRFSQKSPTEQEYSTHHSSTVNKAYDVLKVPLKRAQYLLHLKGIEIEERSTADLQMPELLMEVMELNERIDQAQSEAEVKEIAADIEDQLQHGLRELSSAFKAEKYDVAKQWTIILKYYYNLQQAAHNWGDSRGRVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNJ9</accession>
    <name>A0A0D2VNJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363803.1">
        <property type="nucleotide sequence ID" value="XM_004363746.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNJ9"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNJ9"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1803" mass="198326" checksum="B599C452A6875C1D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPS8</accession>
    <name>A0A0D2VPS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 10">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 10">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_003477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 10"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348382.2">
        <property type="nucleotide sequence ID" value="XM_004348332.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VPS8"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPS8"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="230"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="14">
        <location>
            <begin position="838"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="948"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158781" checksum="99E37BB0D4F12E8F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPX0</accession>
    <name>A0A0D2VPX0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270330.1">
        <property type="nucleotide sequence ID" value="XM_011272028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPX0"/>
    <dbReference type="STRING" id="595528.A0A0D2VPX0"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPX0"/>
    <dbReference type="OMA" id="NTSKFTH"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16455">
        <property type="entry name" value="RING-H2_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000259">
        <property type="entry name" value="E3 ubiquitin protein ligase RIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="15">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="647"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="399"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="694"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE92567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="768" mass="84482" checksum="E9064147C38CE8CA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQB8</accession>
    <name>A0A0D2VQB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_003725</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363453.1">
        <property type="nucleotide sequence ID" value="XM_004363396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQB8"/>
    <dbReference type="FunCoup" id="A0A0D2VQB8">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQB8"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQB8"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="1845775at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQB8"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="143"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="932" mass="99279" checksum="03F4DD821137E8D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQM3</accession>
    <name>A0A0D2VQM3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="23">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_003855</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363583.1">
        <property type="nucleotide sequence ID" value="XM_004363526.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQM3"/>
    <dbReference type="STRING" id="595528.A0A0D2VQM3"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQM3"/>
    <dbReference type="OMA" id="SHRYYER"/>
    <dbReference type="OrthoDB" id="271226at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQM3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269465" evidence="21">
        <location>
            <begin position="28"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="885"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE92987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1174" mass="119365" checksum="3F8B04A7DBCD93D7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQU1</accession>
    <name>A0A0D2VQU1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spore protein YkvP/CgeB glycosyl transferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQU1"/>
    <dbReference type="InParanoid" id="A0A0D2VQU1"/>
    <dbReference type="OrthoDB" id="10661918at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055259">
        <property type="entry name" value="YkvP/CgeB_Glyco_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13524">
        <property type="entry name" value="Glyco_trans_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spore protein YkvP/CgeB glycosyl transferase-like" evidence="2">
        <location>
            <begin position="527"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="938" mass="104196" checksum="D34EA119D23D8121" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQV0</accession>
    <name>A0A0D2VQV0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363673.1">
        <property type="nucleotide sequence ID" value="XM_004363616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQV0"/>
    <dbReference type="FunCoup" id="A0A0D2VQV0">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQV0"/>
    <dbReference type="eggNOG" id="KOG0647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQV0"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQV0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="362" mass="40370" checksum="976BD8C9FE2AA538" modified="2015-04-29" version="1">MAQAAVGPPHNPNNDLEMANAPDDSVSSMRFCPSDTLDYLVVGAWDQTTRVYNVDPMSGQSEQKMVFPMDAPVLDVAWHADCSKVFAAGCNKQTHMFDLGTGQSMPVAMHDQPIKTIRYLTEPGLLMSCGWDRMVKFWDLRSPNCINQLQLAERVYAADAVYPMAVVATADRHVNLIDLRQPSADWRQETSLKYQTRCVAVFPQANGYAIGSIEGRVAVNYPEFAADDKRNFSFKCHRLNEGRLNDGQTRDDVYAVNSIVFHPTYGTFATTGSDGCFFFWDKDSRQRLKPFNRANQPIPCSSFNGAGNVFAYAVSYDWSRGIDGASNQRPHLLLHSVRPDEIRPKPAPAAQPPSYLKSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT50</accession>
    <name>A0A0D2VT50_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT50"/>
    <dbReference type="FunCoup" id="A0A0D2VT50">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VT50"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT50"/>
    <dbReference type="OrthoDB" id="10063861at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT50"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="235" mass="26863" checksum="43964E442D336CEB" modified="2015-04-29" version="1">MCNTTKTSIFKTYRIQSTHQNNEILVDISLDLLQRALKTANNADTVTMRMIRKEETPFLVLDVVLRPQNTRPGQNSRPRLLCQQIPMLILHHSLIDDYQEPVLPRPEVSIYMPSLKLLRNVVERMKTISSHLDIAANNDKTFWLRVDSDMLEIRASFPNLQNPEWRDGLQPEQEATDPKQFTVARVAIKHFAQFLHGHQVGASNVICSIVEGKAVILFLIDDGVALTYRLPIIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUB8</accession>
    <name>A0A0D2VUB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346176.2">
        <property type="nucleotide sequence ID" value="XM_004346126.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RCNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUB8"/>
    <dbReference type="OrthoDB" id="6142675at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253891" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1804" mass="195571" checksum="959B2361E97A786B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVL7</accession>
    <name>A0A0D2VVL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345572.1">
        <property type="nucleotide sequence ID" value="XM_004345522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVL7"/>
    <dbReference type="STRING" id="595528.A0A0D2VVL7"/>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVL7"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVL7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="697"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="951"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108754" checksum="A10AFBF06BBC54AD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYR4</accession>
    <name>A0A0D2VYR4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343863.1">
        <property type="nucleotide sequence ID" value="XM_004343813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYR4"/>
    <dbReference type="InParanoid" id="A0A0D2VYR4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="160" mass="17928" checksum="416E37092C2A1348" modified="2015-04-29" version="1">MGGESVPRGFLKSETFSSMINFLEHPPNDVRSPNSLNTQARIIRVCRTLTVIETWHHVPPEVSERIVHACASLCSVLAVRPIAMQCVETILRFTQTVKLAIDKKYPSVSFKIALQGLFMRAAYGSADRTNLRALMTSLRVRIPPDLPAREPLDMDDPCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZN5</accession>
    <name>A0A0D2VZN5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZN5"/>
    <dbReference type="InParanoid" id="A0A0D2VZN5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254000" evidence="1">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="188" mass="19579" checksum="C564093699FF705F" modified="2015-04-29" version="1">MARAVGLAAVCAALFALGLLAAERSTAIPVRVATDATDGRPDLGASASARCSAVAGIHLRTLALCLIHIRIRQHWKCLDGGAIDFNVMTRRAQCQSTTSVLELISGGYFSRVVPGATTCFVHALSGEIAVQVVSCSVGLVPTTCPSVCVRSHESAVLEPSAGTKDSIVLEVHCAQHARFILVELTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0K9</accession>
    <name>A0A0D2W0K9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342940.1">
        <property type="nucleotide sequence ID" value="XM_004342890.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0K9"/>
    <dbReference type="FunCoup" id="A0A0D2W0K9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0K9"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17544" checksum="E177E6DE8732C32F" modified="2015-04-29" version="1">MPKYNLQVKAELARVEQFQPASAAEYEFHLLLACAHCKESTGKHVNFSLQDEADIPGGRGVANFVAKCKLCSRDFSIEIIKGSIVPYKSSSNNGFATIASFECRGVELTGFEPASGWTVVAEETGTTFTDVDLSEEFAEYDEKASEPVGISSLESRFVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W154</accession>
    <name>A0A0D2W154_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W154"/>
    <dbReference type="FunCoup" id="A0A0D2W154">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W154"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W154"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W154"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="106"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="225" mass="24236" checksum="F37B5798B1F77962" modified="2015-04-29" version="1">MLPSAEQFAQHAGSALGVNNKTHVVVYDSQGIFSAPRVWMTFRTFGHENVSVLNGGLVAWKQANLPLETTKPASVTPSQFIAKLSPNLMRDFPFVDKLVRDKQVSKDNGLQIVDARSSPRFQGTVPEPRPGLAGGHMPGSRNIPFTDLLDPKTQCLLSDDELRQVFARANVDPLRPLVASCGSGVTACVIALAAFQLGNKSAAVYDGSWTEYASQPGALIECAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W168</accession>
    <name>A0A0D2W168_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTP binding protein RAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W168"/>
    <dbReference type="STRING" id="595528.A0A0D2W168"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W168"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W168"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="206" mass="22845" checksum="A9FB494E06E25A17" modified="2015-04-29" version="1">MLGPASARQFNQHQLPPSAGDEAATLAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPASFENVRAKWYPEVSHHCPNTPVILVGTKLDLREDRETIEKLKEKKLSPITYPQGLQMAKDIGAVKYLECSALTQKGLKTVFDEAIRAVLCPTKPPKKKKSCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1W9</accession>
    <name>A0A0D2W1W9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346395">
        <property type="protein sequence ID" value="KJE98347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1W9"/>
    <dbReference type="InParanoid" id="A0A0D2W1W9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="67" mass="7499" checksum="D57E0B6C4D020CE5" modified="2015-04-29" version="1">MSEELKPSVRICGSEGSIEMLDIEHTESGFTETGEFKAYVEPTNREIMAYAAFERVAKIAMNALHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHS7</accession>
    <name>A0A0D2WHS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365610.1">
        <property type="nucleotide sequence ID" value="XM_004365553.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHS7"/>
    <dbReference type="STRING" id="595528.A0A0D2WHS7"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHS7"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="308"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="516" mass="55472" checksum="BCBA118157F4A54F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIQ4</accession>
    <name>A0A0D2WIQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ddhd2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIQ4"/>
    <dbReference type="STRING" id="595528.A0A0D2WIQ4"/>
    <dbReference type="eggNOG" id="KOG2308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIQ4"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIQ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1234" mass="130778" checksum="EAE69696D80AE922" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIQ6</accession>
    <name>A0A0D2WIQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC1 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349690.1">
        <property type="nucleotide sequence ID" value="XM_004349640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIQ6"/>
    <dbReference type="FunCoup" id="A0A0D2WIQ6">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIQ6"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIQ6"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="136"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="878" mass="96598" checksum="DB20EAB8D84B1D9E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ94</accession>
    <name>A0A0D2WJ94_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ94"/>
    <dbReference type="InParanoid" id="A0A0D2WJ94"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="288" mass="30625" checksum="DF3B53443B984B3E" modified="2015-04-29" version="1">MRMPTPPKVVGRLVPSEVTHANNTCVSNIFEKEDLPCAAHRDLSCGADELRGIQRSIAALAACLGVAKTVFAPFSKSLVSNVPDASRCAALLEVLTGQVAGKAKPTGEEKLVVKLLFENLGLHLAAEGIAQCKATGKLLLVTLVHDLKSKKTAEDAANQVARATNQAAEAIAQAKMRIAEAANQVAAANAQVATATNQVEAANARVKELWAKNRTLEARKLELEAKGNANPATFPPVPQLHGVNLTPDVDKWLLTRPELQEKIVNAGDRVLVTAPPIHALPQNLELCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKC3</accession>
    <name>A0A0D2WKC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364809.1">
        <property type="nucleotide sequence ID" value="XM_004364752.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKC3"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
        <location>
            <begin position="2293"/>
            <end position="3071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1733"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1799"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1874"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2047"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2792"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2961"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1901"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2050"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2277"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2961"/>
            <end position="2977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3082" mass="328816" checksum="D4B9C675043BB49F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKF0</accession>
    <name>A0A0D2WKF0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364852.2">
        <property type="nucleotide sequence ID" value="XM_004364795.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKF0"/>
    <dbReference type="FunCoup" id="A0A0D2WKF0">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKF0"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKF0"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKF0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="530"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="738"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1207" mass="136936" checksum="2751D35B6CBA4498" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKY2</accession>
    <name>A0A0D2WKY2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Atypical/ABC1/ABC1-B protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349005.2">
        <property type="nucleotide sequence ID" value="XM_004348955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKY2"/>
    <dbReference type="FunCoup" id="A0A0D2WKY2">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKY2"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKY2"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKY2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="662" mass="75683" checksum="DB2AD64C36383032" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLV5</accession>
    <name>A0A0D2WLV5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349488.1">
        <property type="nucleotide sequence ID" value="XM_004349438.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLV5"/>
    <dbReference type="FunCoup" id="A0A0D2WLV5">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLV5"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLV5"/>
    <dbReference type="OMA" id="EVRFQTQ"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLV5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000079">
        <property type="entry name" value="Ubiquitin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="475"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00071717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="519" mass="53983" checksum="EFEC3007E4F88C23" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMW2</accession>
    <name>A0A0D2WMW2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270167.1">
        <property type="nucleotide sequence ID" value="XM_011271865.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMW2"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMW2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058544">
        <property type="entry name" value="ETR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25487">
        <property type="entry name" value="ETR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="584"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1330"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1463" mass="155989" checksum="7F36596D673A41D5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNC5</accession>
    <name>A0A0D2WNC5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363782.2">
        <property type="nucleotide sequence ID" value="XM_004363725.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNC5"/>
    <dbReference type="STRING" id="595528.A0A0D2WNC5"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNC5"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="164"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="361" mass="37143" checksum="4BCEE66F4A15E868" modified="2015-04-29" version="1">MSDLLDEAVPELNATEAELTPQQSNDNDNNSTSSDNGNNNAAAAHSSGSDNEYDKLEEEDNRIDDEAVVSHQPEPVAAAAAPAPAPVAAVVAAPALAPAPAPAPAPVAAAPASVAPESKKPSSSSSSSSAAAAAASTSASASSSSKGPIVLCSGCTSSSCSVSSCDLLYWKNPVHSGLALVAGVVAIWVLFLSKTTLVAMAAYATLATLISAIAYVHGSQLYLTIIKKQPAVHPFEAFLNNEVHIVNPDVAAEHVRRTLACTHACLQKVKGIVLVADLKTTATFAAGAAGVALVSCLFGCILKFGCVLLATHIGLFTIPKIYQLYQPQIDAQIAALRARAQQLFHQASQKVTDAARKKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNI2</accession>
    <name>A0A0D2WNI2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNI2"/>
    <dbReference type="InParanoid" id="A0A0D2WNI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="182" mass="20812" checksum="EAD74AB67B0433FD" modified="2015-04-29" version="1" fragment="single">KKKKRRGFESEGSEEGLKVTAEAHDKQSVVTQRERKREKERKRERKREANNVSRNLLVVYILSALCLFRSSSSSRMPHSRRVLRFFLLFALSVFAMQREGAPPRRSRSLQQTPTGNSEWVTKQKKKKSNLRIIIIRAVCEPDSHTHTRTRTEVVPIAGCARFGSFSGGGEERNEEEAAAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNI6</accession>
    <name>A0A0D2WNI6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNI6"/>
    <dbReference type="STRING" id="595528.A0A0D2WNI6"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNI6"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNI6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF73">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="423" mass="47545" checksum="DE7DE158EA1F7AED" modified="2015-04-29" version="1">MAALLRHIGGTVVGAAPLAVAFACAPSFTMLWSVMRVATAPLPIRVFERCDVVLYDLYQSFVSFFYEHWAGVRLVFHGDVLPSSAQAATIVPLTADGTKPLLEVQAHGAAAVGNAGAASAAATATAATGAPEAENVLYMSNHQCAADWVMVDLIALRHGALGRIRYMMKRSLRLLPLYGWYFAMHSCVFVRKNWNHDQRGLLVVLDRFRSRNMPIWLVVFPEGTRFEPTQKPAILERSKLYCAERGWPQFEQVLPPRINGFRGCVNGLRNHIDAVYDVTVMYSTSNDLASGRTVRDRTPSMLDLLARRYKRIDIHIRRHPVEALPMSDEGIEQWLVDRFQEKNNRIKSFLENGTFAIPEDEHATFVLPQLVREERVNPWRTFFKSVLLVATLVPFVALEKGRKILFYFCTVGTLAGMAVSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNJ4</accession>
    <name>A0A0D2WNJ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Paramyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363860.2">
        <property type="nucleotide sequence ID" value="XM_004363803.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNJ4"/>
    <dbReference type="eggNOG" id="KOG4678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNJ4"/>
    <dbReference type="OrthoDB" id="21607at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="771"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="903"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109991" checksum="0EBEAFFAA80AF2A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP17</accession>
    <name>A0A0D2WP17_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364151.2">
        <property type="nucleotide sequence ID" value="XM_004364094.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WP17"/>
    <dbReference type="InParanoid" id="A0A0D2WP17"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="520"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="839"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1376" mass="145095" checksum="313C7F0C9FBA5DF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQL9</accession>
    <name>A0A0D2WQL9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270447.1">
        <property type="nucleotide sequence ID" value="XM_011272145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WQL9"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQL9"/>
    <dbReference type="OMA" id="IPETAGF"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF1">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="548"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="740" mass="80179" checksum="84DF662DC5C8CBAD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQN3</accession>
    <name>A0A0D2WQN3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347935.2">
        <property type="nucleotide sequence ID" value="XM_004347885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQN3"/>
    <dbReference type="STRING" id="595528.A0A0D2WQN3"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQN3"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="502" mass="53970" checksum="1502D7C3CEAE7D7B" modified="2015-04-29" version="1">MSDYADISELQPKLASLVIAPVPSSDTLGTSYLQAPGHFNPPTLPPRGRAATLATPTTSDPLYAVVDKKLKTAVLGNAAPRPHDRFTEAELDSVFDDLDIMASAILSAGKGAGMNTVAFRDAAPSPLVAPRPASLFFPDGEKPPLPANHPAERTKSDVYDVPADTILSAAAARSLTSAQSFVSSPEYESFSDLKKAPATLPRSAQLNYASLAHASGAEAAQALAPEPAKKEEPAAEPVPQHDAAGVPLCATCRNPVTSTQPALEALGRTWHHDHFVCHACKLPITGNFFHHNDMPYCHRDYLNAIAPKCALCNLPVVERGLHAMNKDWHAACFACAKCGSPLKEYMLVNGKPYCQEGTCKVSLSSADVKQGDHCRGCQALITDEFLVALGAHWHKPCFCCKTCGSQLQDGGFFVHEGHPYCILDYQAVTGVICVTCSKPIVGEVLTFNSSYYHKTCFTCERPGCPEVLGGQFYNFNNKRFCVAHGTEMLQNLTAKYIYTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQU1</accession>
    <name>A0A0D2WQU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQU1"/>
    <dbReference type="InParanoid" id="A0A0D2WQU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="55" mass="6551" checksum="44281F981BFD4EFE" modified="2015-04-29" version="1">MVAKFQPSCIRQLVMPVHANDDQEIAQATPRKRRRMSLDLRRQIVALRDKDLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR47</accession>
    <name>A0A0D2WR47_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR47"/>
    <dbReference type="STRING" id="595528.A0A0D2WR47"/>
    <dbReference type="InParanoid" id="A0A0D2WR47"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="391"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="520" mass="52352" checksum="53F1CD9093650B6F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRF5</accession>
    <name>A0A0D2WRF5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346796.1">
        <property type="nucleotide sequence ID" value="XM_004346746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRF5"/>
    <dbReference type="InParanoid" id="A0A0D2WRF5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1221" mass="127310" checksum="9CA457FD9D56D29D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRL9</accession>
    <name>A0A0D2WRL9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347391.1">
        <property type="nucleotide sequence ID" value="XM_004347341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WRL9"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRL9"/>
    <dbReference type="OMA" id="MAHPMGP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="331" mass="35540" checksum="11A4094012150361" modified="2015-04-29" version="1">MLSAVSRASAVRAFSSLAARAEAQHPIKNVTIFGAGFMGAGIAQVSAEAGYNVKLVDVSSAAAEKGVAGIKSNVARDARKKFAELAKTSAEQAAESERKHVEAIVGRIQATDKLESAVAEADLVIEAIVENIKVKQDLFRKLDAHAPKHAILASNTSSLRVTDIASATNRRDRVGGLHFFSPVPVMKLVEIVRTDDTSNDTHAALLDFGKSVKKVTVSCKDTPGFVVNRLLVPLMLEAIRMLERGDASKEDIDAAMKFGANHPMGPLELGDFVGLDVCHSIIEGWHQSYPDVQLFNPSPLLTKLVSEKKFGRKTGEGFYVYPPAAPKPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRR8</accession>
    <name>A0A0D2WRR8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRR8"/>
    <dbReference type="InParanoid" id="A0A0D2WRR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="212" mass="23507" checksum="5226CEE66F9B2E08" modified="2015-04-29" version="1">MTAIAVGDCFEQPFRAFNNRELDLTEGCPFGIVLRVYTHDVVMVFATELGWDPEQDGAVTNVMVHKSPSEHFTVSVCPLLVYTRDKRTLAGQPVGRVHDVSSLIPPRPTRRLLVRSLCCPHVDSNITDQRPCVQVSPVCQRSNFALCLMITTGAQGATSEHLVNIDELGWEQRTKAVIGSLHTYRLFCAYVDPSQPVLGTLDGELVAARLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WT94</accession>
    <name>A0A0D2WT94_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345623.1">
        <property type="nucleotide sequence ID" value="XM_004345573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WT94"/>
    <dbReference type="eggNOG" id="ENOG502SEVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WT94"/>
    <dbReference type="OrthoDB" id="10668092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WT94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="266" mass="28642" checksum="9D7C3C1FA1412021" modified="2015-04-29" version="1">MGVLSQVNARAVVIASVVVSLTTIFGCYATAVHLHHVKAWLPMISDCGVDAPEKYPFRLGIISSALLIMFNAYLVWAISGSSASKSNTVAFISALGGAAGLAVVGAVNEAEDNSVHGTAAVIFFFLYELYMIIITVNLFHVRGKTAQGYRAVSDFSLTLKVFALTVGTVALALFVYMNSDWGKYSLQIAICEWTGTMMIQLFNISFVFEYGTDYKLDATIVNSVASYAAPKQPALPLMFVAVASPRVNSKTGEWLDQVAWKPAAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTU8</accession>
    <name>A0A0D2WTU8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTU8"/>
    <dbReference type="STRING" id="595528.A0A0D2WTU8"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTU8"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTU8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="63773" checksum="8365B6915E14D779" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU74</accession>
    <name>A0A0D2WU74_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345462.1">
        <property type="nucleotide sequence ID" value="XM_004345412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU74"/>
    <dbReference type="STRING" id="595528.A0A0D2WU74"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU74"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="30621" checksum="4B9D75EE266A1B2B" modified="2015-04-29" version="1">MSLVLLRLVQQRSAPALLARQSQRAAASSASTSNAKPASSAQTQQQTTAAAIAAAVPKTPGMAEFFESQAARDVPFDGRRWSTQELRLKSFEDLHKLWFVLLKERNLLLTHMHYERSQNRAVPSYTRRMQMVKKSMGGIKRVISEREIALNMAKSAHGLAFKRTRIAAAAPERDDEKVRFQPLIEERTRIKAWQVKDKPSMAHLEEATEKTMSHLETIRAALGAHGRKLSLRQALLRGAAIATLQHVTGVPASAPASSPTSDTTTETTSQAPPPSTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUY3</accession>
    <name>A0A0D2WUY3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_006281</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345030.2">
        <property type="nucleotide sequence ID" value="XM_004344980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUY3"/>
    <dbReference type="FunCoup" id="A0A0D2WUY3">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUY3"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUY3"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUY3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="16">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE95878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="238" mass="26302" checksum="0F437371674C184E" modified="2015-04-29" version="1">MAELISIGLGEEGMTDTHRLFVQALMSRTLIAENDLQELFKQVHVATGKQPGTLNEFLKIIKANLDIISFDITSVKSEDDGRRYFALVNRYADEISKMASDYEPQEMELLNKLVELITLSDSGTASSIDVDNVAPLLTRPLTKAAAEVAVRKFTHDGWIHDDEGTLSLTTRTILELEPHLKESFSEHVIACAACSSLVFRGQVCKQSGCGGKLHNHCLALFRGTRPNFACLTCKADFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV81</accession>
    <name>A0A0D2WV81_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV81"/>
    <dbReference type="FunCoup" id="A0A0D2WV81">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WV81"/>
    <dbReference type="ESTHER" id="capo3-e9cft4">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV81"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="509" mass="57858" checksum="B33B6E2F84FFA0BE" modified="2015-04-29" version="1">MLTLSFMLSVPVGNRFVQFTLGGYARLLFAILVLVVESAVRLVFMFVPQPVTSGLDFVRAHLIRQGVRLFRGYMDANEDPAMDMTTVQLIQHFGYTAEEHIVKTDDRFVLTLHRIPRRKNESHSVNGDRPAVFLMHGLMMCSEVWVATNDSLAFMLADHGFDVWLGNNRGNRYSHKNTKFKPSQNHFWDFSVDELALYDVPANLNYILDLTQQKTLSYVGFSQGTAQAFASFSLNPQLAARVNMFVALAPAGRAKGLKKGVIGSFVRLAPDSIFLMFGAKACMPSALFWRNLLARNSFTSLIDASCRLLFGWRMANFGSQDRKNMLFAHLFSYTSVKTIVHWFQMVAMNQFQMYDENQDLAKTPYRGTTPNPYPVHQIKCPMAIFYGGADGICDVQWLLDQMPKNTFIHRQDEYEHLDLIWAASASTCIFPKVIRIIKETVEREAEHELQRRKREEECAHEIELLERANDISVASANAGRHFQRRISAHLSSSTLLPCESQDSGIDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVB4</accession>
    <name>A0A0D2WVB4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343767.2">
        <property type="nucleotide sequence ID" value="XM_004343717.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVB4"/>
    <dbReference type="FunCoup" id="A0A0D2WVB4">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVB4"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVB4"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="36"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="292"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="47631" checksum="2DED497C5BE16BD9" modified="2015-04-29" version="1">MMDAHDDAAVIRARTESTSGAAGSSSQTALEPYDNAALQIFVTDPEKHGSGMDAYVSFCVTTKTTMQEFQAQEFFVRRRYTDFVWLRSKLFSEFSTSVIPQLPSKDVAKHLNRFSPEFLEKRRYFLERFLRRCASHAKLSTSKDLHTFLEAKKWALDTAKKEKGEFLSSVKDSIDKRVASYKLKNPDERFANLRSHANSLGEHLTSLEKIGTKVQKHASDIADDLQEMGPVFTMLANSESELRDVFTQAGQAFDKLATIGHETAEKLDALYNNPVHEYVLYAAASADLLDKRDVVEYQCENAQNTLMKHENERNSLESSDGKAGLGSFFSSKNPELLKQEKLDKLATAIAEDEQTLREKQQEKKETDELVLQEFDSWHSRKVKDFKKILTDLANAQIAHHSQNLKIYESLLPHFEKIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWS2</accession>
    <name>A0A0D2WWS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCY1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWS2"/>
    <dbReference type="FunCoup" id="A0A0D2WWS2">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWS2"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWS2"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="731" mass="79202" checksum="6EE8A84E0C71CE9D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWT3</accession>
    <name>A0A0D2WWT3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343199.1">
        <property type="nucleotide sequence ID" value="XM_004343149.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWT3"/>
    <dbReference type="FunCoup" id="A0A0D2WWT3">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWT3"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWT3"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12033" checksum="CDBA6EF54E0BC5B7" modified="2015-04-29" version="1">MSSDITTTESKQQQQIASEAQLGAKWDRCFTNMLVHTGVGAGVGIVLSLIFFKRRMAPVYLSTGFAIGTAYQQCQDDFASARATGKVVRISEAALQQFVQQQEKQQKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX05</accession>
    <name>A0A0D2WX05_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX05"/>
    <dbReference type="InParanoid" id="A0A0D2WX05"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="886"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106668" checksum="B98CE1CA3AD00EF2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX89</accession>
    <name>A0A0D2WX89_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX89"/>
    <dbReference type="STRING" id="595528.A0A0D2WX89"/>
    <dbReference type="eggNOG" id="KOG3454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX89"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="222" mass="23718" checksum="1139911C926FDCC8" modified="2015-04-29" version="1">MPRYFCHYCQAHLTHDSSSVRKTHISGRKHKEAVKLFFENYINENGWPRFPWRAEPFHPMPIEQDWAPPGAERRRRFTPRGGGGGGFRGGDRGGDRGGDRGFDRGGDRGGDRGGGDRYGGRDDRGPRPSYVGGGPSVAPSYNGNAAPAPPPSYNRAPLTGANAAPFGGGGGGGGYAPPPPAGYASFGGAPPPQQHYQPQSQHHGGPPNPYSQQQPPSGYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYA4</accession>
    <name>A0A0D2WYA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343035.1">
        <property type="nucleotide sequence ID" value="XM_004342985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYA4"/>
    <dbReference type="STRING" id="595528.A0A0D2WYA4"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYA4"/>
    <dbReference type="OMA" id="EIFAKCG"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="12710" checksum="013CB40D7D1C1C5B" modified="2015-04-29" version="1">MSSRSPSPAARSRSRSPVAARSRSRSRSRSRSPSRSPVRNAGGRQGGRGGNGRNRSVLPPRATLHVRNLTYDARPDDIREIFAKCGNVKDIYLPRDYYSNKLRGFGYVEYRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0C1</accession>
    <name>A0A0D2X0C1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365253.1">
        <property type="nucleotide sequence ID" value="XM_004365196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0C1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0C1"/>
    <dbReference type="InParanoid" id="A0A0D2X0C1"/>
    <dbReference type="OMA" id="PISCEAQ"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1018" mass="102840" checksum="F2DFA7EA32D04DBA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0E0</accession>
    <name>A0A0D2X0E0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365340.2">
        <property type="nucleotide sequence ID" value="XM_004365283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0E0"/>
    <dbReference type="InParanoid" id="A0A0D2X0E0"/>
    <dbReference type="OrthoDB" id="14788at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022166">
        <property type="entry name" value="UBAP2/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="119158" checksum="86C1A70913B17645" modified="2015-04-29" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Y4</accession>
    <name>A0A0D2X0Y4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0Y4"/>
    <dbReference type="STRING" id="595528.A0A0D2X0Y4"/>
    <dbReference type="InParanoid" id="A0A0D2X0Y4"/>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0Y4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="219" mass="23534" checksum="44C6CD00FA730C27" modified="2015-04-29" version="1">MIENRQAIKIGYVKHCNTCGRKIAAGETFALKGQLLYCKADYDQLAAGLTPSSSARSSAAGLTPGGYSDPPLSPSSRHSANFPGLQRQFSAPTGSPPHALERRASGSAADQRRLSNKSARSSLNSIITDPASPLNGLDSDGMPKRVRTKITPEQMDTLMASFELNMTPDAATRERLAAITGLSIRVIQVWFQNKRATYKKKRDSGLAEWAPISGRKGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X180</accession>
    <name>A0A0D2X180_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X180"/>
    <dbReference type="InParanoid" id="A0A0D2X180"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="106" mass="12249" checksum="6C2CCBFC21B3B5B3" modified="2015-04-29" version="1">MELTLMNLTACEFLFFFSFVHVCFCVVFVVFCMSIGCCPIRGYACEKNFDEMTKRSAHIPPGARWDCLQGGVHVPFRARRCIFSPAFFLSPTFPTYVHYLHYVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1J3</accession>
    <name>A0A0D2X1J3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348892.2">
        <property type="nucleotide sequence ID" value="XM_004348842.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1J3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1564" mass="167248" checksum="0F15A8757F7ADBC4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1S8</accession>
    <name>A0A0D2X1S8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349236.1">
        <property type="nucleotide sequence ID" value="XM_004349186.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1S8"/>
    <dbReference type="InParanoid" id="A0A0D2X1S8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="8">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="242" mass="27077" checksum="6DD00CB20B3624CA" modified="2015-04-29" version="1">MQHKVRAAVRALRSPAAILERVNRLVVSDAVSRPGWFNVVERIPPPQHAHRPSPAPPKIVFPEDGLRRSARRIRGEGVDIVGILPSIQMNESHKFTVKTDGDRITQEYTRLRKEEKLSHPEALARAIPESHRGTYLQRYVAAVRKIREANATEFKLMGAAAPDMGPQPTPPAVPALLESKAFLPYVDSLFASRARNDPRRRSALFNSASQRRQSPIHLRGSQTRNPFDPFNAKDQPTIGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2A0</accession>
    <name>A0A0D2X2A0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2A0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2A0"/>
    <dbReference type="eggNOG" id="KOG0904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2A0"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2A0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05165">
        <property type="entry name" value="PI3Kc_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="300"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="750"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118046" checksum="690482E2549C7416" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2D2</accession>
    <name>A0A0D2X2D2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2D2"/>
    <dbReference type="InParanoid" id="A0A0D2X2D2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="384" mass="40059" checksum="4B3F144B73D85ABA" modified="2015-04-29" version="1">MEASSSDQRLADLDRRFAELERSFLVDDAMATDDNDDLILAQQQQEQDHQTHDEHRQQQQQLQQHRSLSSSGSAPVSSSAASMLDDDEDLADENAARAMIEQLVQARRDRAAAATLESEPLQQIRAADGAAGSVVRPDGRAHVTATTASASTTPHTATPTTLTPKPATRTPLMDAARAAAGAGNAGGRLEDDRAQIHAPAPAPASAGATGMTINTPAVVAPNAPQQARIIDQVAGTPPGLTPPGEVSSQSKTSPAAPAHAASAVAGTAAAQYAESASAEVNKIWHAHRQQVDARLANLLLKFGPNPAAPNGGAPAPDHPLGAVLCKEHLAVDSDTAGIARRCRVSARGCTTERIPSRRHQTHLFGLAGQSPKQSKSIARTNDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2K4</accession>
    <name>A0A0D2X2K4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID complex 60 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363357.1">
        <property type="nucleotide sequence ID" value="XM_004363300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2K4"/>
    <dbReference type="FunCoup" id="A0A0D2X2K4">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2K4"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2K4"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2K4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="7">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="541" mass="58059" checksum="D32946557760562B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2U2</accession>
    <name>A0A0D2X2U2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347808.2">
        <property type="nucleotide sequence ID" value="XM_004347758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2U2"/>
    <dbReference type="STRING" id="595528.A0A0D2X2U2"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2U2"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2U2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254995" description="rRNA methyltransferase 2, mitochondrial" evidence="9">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="326" mass="35144" checksum="7578E83C006A0CB2" modified="2015-04-29" version="1">MLRSTAVRLFSTLSLHGSIAATAAASGSRLGASSSRWTKRQQSDPYVHQALEDGYRCRSAYKLKQLDDKFHFLRTPAGQAAASKRATASTATAAQPVVVRSGLVVIDCGARPGGWTQVAVERVGKDFRDLLLRHSNETKQSSGTPPMAGAQQNEAHIDKEEQAQLKPNATNASSIATSNGAANAPPSPPLSPLVLAVDIEPMERVPGAIVLPQADMTATRTHNQLAAILGTRLVDVVLSDMAPPASGNAGVTHLQCVNLIEAALRFATRFLRIDGWFVCKSFHGTEDQLLTTTLRRHFREVHFCKPPATRTESGEFYYVCEGFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Y4</accession>
    <name>A0A0D2X2Y4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347989.1">
        <property type="nucleotide sequence ID" value="XM_004347939.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Y4"/>
    <dbReference type="OMA" id="STHEDAY"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1401" mass="146660" checksum="09EBA5518E496A1B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3F4</accession>
    <name>A0A0D2X3F4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3F4"/>
    <dbReference type="FunCoup" id="A0A0D2X3F4">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3F4"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3F4"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3F4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47352">
        <property type="entry name" value="CLASS I PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47352:SF1">
        <property type="entry name" value="CLASS I PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="114" mass="13067" checksum="7A1CE22E66CE38E7" modified="2015-04-29" version="1">MLGGVTDRVSVTFARSSGPGGQNVNKVNTKVELRFNLSEASWIPERVKNRLVQFNIEDAFEKLEVMLAKASELPTETSPEQQAKVRRLERAANERRMMEKKMHSSRKSSRRDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3G1</accession>
    <name>A0A0D2X3G1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347669.1">
        <property type="nucleotide sequence ID" value="XM_004347619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3G1"/>
    <dbReference type="STRING" id="595528.A0A0D2X3G1"/>
    <dbReference type="InParanoid" id="A0A0D2X3G1"/>
    <dbReference type="OrthoDB" id="61288at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3G1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="407" mass="44905" checksum="C548DFDB330DC4EA" modified="2015-04-29" version="1">MSGTHTPSAATPAVSGCPVMHHGMSRGNMAVCPVTGMSAPPTPNRSRSGSISSVSSSTSQSSALSAHSALSSRSTTSSMSGISDLGPMLSSQMLDLLRHETRDAIQSSWALAIQKHDDHDVTPVATFVNILFAKLFEVCPETRLVFGHDMVRQGKSLSSILTGMLEFVVHPKKLQSQVKRLAHMHVGLGVTPDMFEAFGFSLLYTIRVRIGSAWNQQIERVWVDTYGGVSNILSQHMSHITLDANDIPSWMVSRYLEHHAVMMATWKEATDADSGERVLNGFFTRLQVNDPQASHIYETADARMRKVIIWSAVTKILDCLENPRSLRKELKPLAQSHAHMGVTPQMIDAFGTSLCAVLKEVLQEKYTTEVDVVWRRCFRLFAAQFSLSLERYSKSKNKNGKQACVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3M6</accession>
    <name>A0A0D2X3M6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346888.1">
        <property type="nucleotide sequence ID" value="XM_004346838.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3M6"/>
    <dbReference type="InParanoid" id="A0A0D2X3M6"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="360" mass="39769" checksum="16BF31D2CD01D3EF" modified="2015-04-29" version="1">MIPRLVISFTSHPTAAATTALRSLSTLARASAQQHQHHQHQHQQHHHSQDGAADPVQRTVARIVALPSALTTLQPATSSGNTSWLFHCLTDRTVIGDETSKPETPQQQQQQQATSAENLLSDNQAPASNAKVTIVQRISNAASDQWHEMETAPPESMRGRMYAIIQKLQSKVDPAELFFKDVSVRIHHARTHAHKHIPDVPEVFGQCDVVEILHPLQQPAEFGAIQHNLGSLATDYRKRLDRRMAMYVALVPLTAMMSVVPGPNIFLLWNALRLHSIIKARQGCAFLTDACAKNAKRRPSLLIIQSAQAPELADAALHVKTHAELLDAAATILLEPTLPVRLDRLQQRFSKLSLAKDANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3R6</accession>
    <name>A0A0D2X3R6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3R6"/>
    <dbReference type="InParanoid" id="A0A0D2X3R6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="117" mass="12902" checksum="0AE88854B8B7A1FB" modified="2015-04-29" version="1">MHPSEPVELLVVGDPRCLPSQCNSTNSCSVRLYRFCSMMCSREKKISAAVLCDLCVRDRLFVFCVFVVSFFFPPPSSPLPVRSDRPSLFYFGGALSNPRLGIQGLSGTFVFLSATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4D0</accession>
    <name>A0A0D2X4D0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polynucleotide kinase-3'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344997.2">
        <property type="nucleotide sequence ID" value="XM_004344947.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4D0"/>
    <dbReference type="FunCoup" id="A0A0D2X4D0">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4D0"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4D0"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4D0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270415" evidence="2">
        <location>
            <begin position="17"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="633" mass="66722" checksum="534EFDE2C8DC9A4D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4J1</accession>
    <name>A0A0D2X4J1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345263.1">
        <property type="nucleotide sequence ID" value="XM_004345213.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4J1"/>
    <dbReference type="STRING" id="595528.A0A0D2X4J1"/>
    <dbReference type="eggNOG" id="KOG3130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4J1"/>
    <dbReference type="OMA" id="IMHIVEP"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4J1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="403" mass="43024" checksum="8641955604864331" modified="2015-04-29" version="1">MQREQLAYAQQSFMQATEALRHEQRQFEHFQADYRALRQTLTSLTDKTSHPAMIPLGSLAFMPGRLVHTNEIMVLLGDNWFVERSAKQAAEIVLRREQFVDQRLAALERQLKSMQTRTELTHDYLAEMDDAESGEIMHIVEPVPDTDADDQDDEAARNAARARQGSGYLVSNDEINSMVNTKDVPAPSASSASASKGKQPLQSAMKKKESSAPVVASPAASASASSSSSSSSSSTTGPASATASTSASAAGSSAASASPAKSVHFNPDIESVEITPENIRLTPASSASARRPLIMEIENGVAVPPSQPESFDEAADSEPVLFPLKTVTPRADLNTPATITERSIPQPQSLSSGAVSTRLVERPTAAAPLVGGIVERSPRAPAPQTATGEKKMSKFKAEQLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X501</accession>
    <name>A0A0D2X501_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343916.2">
        <property type="nucleotide sequence ID" value="XM_004343866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X501"/>
    <dbReference type="STRING" id="595528.A0A0D2X501"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X501"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395555" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="645" mass="65008" checksum="F674F3C37B44114D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5D6</accession>
    <name>A0A0D2X5D6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343310.1">
        <property type="nucleotide sequence ID" value="XM_004343260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5D6"/>
    <dbReference type="InParanoid" id="A0A0D2X5D6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="612" mass="67546" checksum="A5BF374D0C29DDC4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5H3</accession>
    <name>A0A0D2X5H3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342988.1">
        <property type="nucleotide sequence ID" value="XM_004342938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5H3"/>
    <dbReference type="STRING" id="595528.A0A0D2X5H3"/>
    <dbReference type="eggNOG" id="KOG2257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5H3"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5H3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="199" mass="21888" checksum="411174E2529E2B4D" modified="2015-04-29" version="1">MATRRSARLLPGPPPQTPALSATALSPSSQGEVAPTRLDDRAGPSSRRSANSISISKPATLVVKDPNAPSREIYGFVFYLAAWAAWVAYILWAVVPDEYLRMVGITYFPQKYWAVAVPAYACMIWVFIYWFYLASNLLRVPALDSTATILDSHTVTRPAAAILAEIEHPQAIPALADIPVSTVHRVMFPDEDDDNKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>E9CI05</accession>
    <name>E9CI05_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_007456</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343315.2">
        <property type="nucleotide sequence ID" value="XM_004343265.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270786.1">
        <property type="nucleotide sequence ID" value="XM_011272484.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.E9CI05"/>
    <dbReference type="eggNOG" id="KOG1388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CI05"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007654499" description="CUB domain-containing protein" evidence="13">
        <location>
            <begin position="35"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="855"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="951"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE97633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1306" mass="139416" checksum="077DACFFA60491D1" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9CJQ2</accession>
    <name>E9CJQ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">TKL protein kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">TKL protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008354</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346411">
        <property type="protein sequence ID" value="KJE98388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346411">
        <property type="protein sequence ID" value="KJE98389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346411">
        <property type="protein sequence ID" value="KJE98390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004340834.2">
        <property type="nucleotide sequence ID" value="XM_004340786.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270950.1">
        <property type="nucleotide sequence ID" value="XM_011272648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CJQ2"/>
    <dbReference type="STRING" id="595528.E9CJQ2"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CJQ2"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="493"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE98388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="782" mass="83428" checksum="D318B56B9F0A8760" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZG2</accession>
    <name>A0A0D2TZG2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZG2"/>
    <dbReference type="STRING" id="595528.A0A0D2TZG2"/>
    <dbReference type="InParanoid" id="A0A0D2TZG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268211" description="LRRNT domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11622" checksum="356E055A8D38BB85" modified="2015-04-29" version="1">MSRRVVLLLLLLVALVAALVRSAEAVCLFGLNLSLLLCTCDYADVTCDGPLSGLLVGEIPVGATSFTQINNPGITALASRLLSLAVPTLITLYVSVSGVGGFCIFFFFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U203</accession>
    <name>A0A0D2U203_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365637.2">
        <property type="nucleotide sequence ID" value="XM_004365580.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U203"/>
    <dbReference type="FunCoup" id="A0A0D2U203">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U203"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U203"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U203"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000166">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="14870" checksum="F103DBDE2040BBCB" modified="2015-04-29" version="1">MPPKPQKTKEAKAIAAASGGKSKKKKWSKGKVRDKLNNAVLFDKDGYQRLLKEVPSYKLITPSVLSERLKIRGSLARAALKELADKGLVKLVESHSAQYIYTRSTKGDEMAAAAEAEAAAAATTKGGKKGGKKEAASADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U239</accession>
    <name>A0A0D2U239_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365662.1">
        <property type="nucleotide sequence ID" value="XM_004365605.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U239"/>
    <dbReference type="eggNOG" id="ENOG502SCT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U239"/>
    <dbReference type="OMA" id="EDMGLNQ"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="22391" checksum="6559204B68CBF5D9" modified="2015-04-29" version="1">MTKPSSLKPALKAGSSPSHRSSSNSSASHTAPSTAKSPIAAVAGAAGVGGKKSSKQPATRAAIPVVPSSTNKTKTVPLTSSKAAAATNSEVQLARPQADQQSSKSKKAAKKANAKAEKDEEDDDDIDALFAESTKTQAKVREAKAAEAAIEAAAQAKANLLARYAAAAANDDDSFGDSRGAKSRKRIEGYNVYTEDELKLSTTGGDTPLCPFDCDCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U408</accession>
    <name>A0A0D2U408_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_001322</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349842.2">
        <property type="nucleotide sequence ID" value="XM_004349792.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U408"/>
    <dbReference type="FunCoup" id="A0A0D2U408">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U408"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U408"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U408"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="44354" checksum="6CD9893B811F38AE" modified="2015-04-29" version="1">MSKGETDPEVLYTKMERIGKGSFGEVFKGIDNKSKQTVAIKIINLEEAEDEIEDIQQEITVLAQCDSPYVTRYFGSYLKGSKLWILMEYLGGGSALDLMKPGPFDEVYIAIILREILKGLEYLHEEGKIHRDIKAANVLLSENGDVKLADFGVAGQITETMTKRTTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELVKGEPPNAELHPMRVLFLIPKNPPPTLEGNYTKPFKEFVSMCLNKDPADRPTAKELLKHKFIKGAKKTSTLVELVDRFKRWQAEGGDDGSSSDGSDDENEDGEEGDGNWDFGTVKAAKKGTVKRAPAAAGAAPSAAAPAVAAPPAPVVSPSLAKKVVPGLNKVESSLEDKAIASQIAQIKKAFEMAEASNPGITDKIVAQLVARVRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U426</accession>
    <name>A0A0D2U426_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349855.1">
        <property type="nucleotide sequence ID" value="XM_004349805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U426"/>
    <dbReference type="eggNOG" id="KOG4030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U426"/>
    <dbReference type="OMA" id="HMGNEVV"/>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U426"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="212" mass="22831" checksum="84E8F7B11B94FE8A" modified="2015-04-29" version="1">MNHLCYQLFSCFGGPPDDRDNIIAATAAANARQSNAAAGASGDGRPEVLLDSRHMAPDCVIVKAGKRLCGSGAVLATAPLAQDKSYFEVKLQAAGRWGVGVASRKEDLAAVPLGNENSWVLRSDSTTWHKQQLGSVDVKFEEGDVLGFSYDHVELNIFHNGKALNCPIIGVRGTVYPAFYVDEGAILDVIFHTFVHTPPTGFTEIMLEKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4T8</accession>
    <name>A0A0D2U4T8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364367.1">
        <property type="nucleotide sequence ID" value="XM_004364310.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4T8"/>
    <dbReference type="FunCoup" id="A0A0D2U4T8">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U4T8"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4T8"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4T8"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="244"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="523" mass="57049" checksum="E752D17F8A75E831" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9H3</accession>
    <name>A0A0D2U9H3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348629.1">
        <property type="nucleotide sequence ID" value="XM_004348579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9H3"/>
    <dbReference type="STRING" id="595528.A0A0D2U9H3"/>
    <dbReference type="eggNOG" id="KOG1011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9H3"/>
    <dbReference type="OMA" id="DEWHAVQ"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044511">
        <property type="entry name" value="At1g03370/At5g50170-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46296">
        <property type="entry name" value="BNAA05G37250D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46296:SF8">
        <property type="entry name" value="OS06G0297800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="252"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="6">
        <location>
            <begin position="523"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="83681" checksum="A90059BB4FCF6C92" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9R2</accession>
    <name>A0A0D2U9R2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAMK/CAMKL/PASK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U9R2"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9R2"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000351">
        <property type="entry name" value="PAS domain-containing serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1750" mass="183611" checksum="54D148CFFBA1A2BE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA00</accession>
    <name>A0A0D2UA00_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase 1 alpha subcomplex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363789.1">
        <property type="nucleotide sequence ID" value="XM_004363732.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA00"/>
    <dbReference type="STRING" id="595528.A0A0D2UA00"/>
    <dbReference type="eggNOG" id="KOG3365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UA00"/>
    <dbReference type="OMA" id="ENQWKWP"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UA00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="113" mass="12745" checksum="42A66C1D7C64EF25" modified="2015-04-29" version="1">MSSKASTGLVGLAVNPSARLSLVNLYRQTLQVLGGFPQSAVYRQHAEKLTNHRLSILDQEPSDDAAERRINSGQMEELVRQAEDELALAKKMGEWKAWEKLSVQPNSEQWKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAN6</accession>
    <name>A0A0D2UAN6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363952.1">
        <property type="nucleotide sequence ID" value="XM_004363895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAN6"/>
    <dbReference type="FunCoup" id="A0A0D2UAN6">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAN6"/>
    <dbReference type="eggNOG" id="KOG4071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAN6"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="191" mass="21929" checksum="2ADF8E638BA72983" modified="2015-04-29" version="1">MAKRFLEFTAAEVEFLAEDTIITIVPNFQMDMLFFISGTVGPFSPSLPVQVPVWLACTLKTRKRCSIQAPEWLDVAYLSAKLDEERMFHDRFIEMPEHFMEISAMLLECASDDIRNASQLRGIIEDICEIRYAKARHGLSILQDNPVATQVNNLSLMEINSIRPFFIHAMNEFRNFAQTLQATRIRANEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCU9</accession>
    <name>A0A0D2UCU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP-ribosylation factor-like protein 8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003774</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363502.1">
        <property type="nucleotide sequence ID" value="XM_004363445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCU9"/>
    <dbReference type="STRING" id="595528.A0A0D2UCU9"/>
    <dbReference type="eggNOG" id="KOG0075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCU9"/>
    <dbReference type="OMA" id="FRNMWER"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="184" mass="21056" checksum="C8FD35080BCC2198" modified="2015-04-29" version="1">MSWFKAIVEWFKSLFWKEEMELTLVGLQNSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKLWDIGGQPRFRSMWERYCRGVNCIVYMVDAADHEKLEAARNELHGLLEKPQLNGIPVLVLGNKNDLPDAFSVEELIVRLNLKAISNREVCCYSVSCKKQDNIDITLQWLIKHSKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDV6</accession>
    <name>A0A0D2UDV6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347903.1">
        <property type="nucleotide sequence ID" value="XM_004347853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDV6"/>
    <dbReference type="FunCoup" id="A0A0D2UDV6">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDV6"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDV6"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="184" mass="20990" checksum="6BC6DA6CAD26E534" modified="2015-04-29" version="1">MSSPKRRLETDVMKLMMTDYNVNLVNDSMHEFVVKFHGPKNSPYENGVWKVRVEIPSAYPYKSPSIGFLNKIFHPNIDETSGSVCLDVINQTWSPMFDLLNVFESFLPQLLHYPNPTDPLNGEAAALLMREPEQFRTKVKDYIQRYATETALKEAEESEADKPDSDLSSLDSFSDDDATADMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE86</accession>
    <name>A0A0D2UE86_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348054.1">
        <property type="nucleotide sequence ID" value="XM_004348004.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE86"/>
    <dbReference type="STRING" id="595528.A0A0D2UE86"/>
    <dbReference type="eggNOG" id="KOG2181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE86"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE86"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="508" mass="55267" checksum="3EF730F5439B292F" modified="2015-04-29" version="1">MDTAFDSAFPQPYLGRQTAAAATAAAQAAAGHAAKQQRLQLEWSATMLKQLQPQDKQQLPSSSTTTTNTTTTTSTTSTTSATPQSQAQQTPAVQGARLPDSTSLSALSLSRGMMTTPVPVPVAPAAMYMSSGRCLARMLQMNELLNHNRLNSLGWWQQFTTEFFATDAIIQYSLWNSVDGTTRSFDFPAALLPRFYKAHFDSGITELALLMKTPRELPRDSSKAPVLLESNVASLLHGFDKTTQVTFNGQFQATFDQDAKITCWRFDVQNFREYVLRDAVAAVLPPPSPINEYGMTKPVMRCLELAENVVHLDDIISASGANTSPADIMGLIISERLQLILQRERQRSEYPLPPFTNNSGQQSVPDRAFEFHAGADDHERSVGSTSYDTFLPANQEANVQAWLGSRIPYSPHPVTSNKPQASTGSVAVGKPDPASTQATPSIVAVLNAAREASLLHSLANLTPEQRVAAMQAIGKTATQTTHVNYLAHSPKTTLSQPSVHSPNEFMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJS0</accession>
    <name>A0A0D2UJS0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345396.2">
        <property type="nucleotide sequence ID" value="XM_004345346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJS0"/>
    <dbReference type="STRING" id="595528.A0A0D2UJS0"/>
    <dbReference type="eggNOG" id="ENOG502QW4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJS0"/>
    <dbReference type="OrthoDB" id="661220at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJS0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029327">
        <property type="entry name" value="HAUS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219">
        <property type="entry name" value="AUGMIN SUBUNIT 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14735">
        <property type="entry name" value="HAUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42581" checksum="390165B903C18FEC" modified="2015-04-29" version="1">MNKLQPLGMQSGVALSSSSAQAVSAAAGIDADVLERHPHFARMVEALLQTTALVSGSTSAGSLGGAGIPRATHEALKRTRADADVQRQAYLEAACVYSELEAALLVQPQSSEEQRIQANAACIEAAQVVHLSPRDGRGSSSQASDDRQSTKQAEFGAKSARHSAGETLLGLSSADLAQDASDELAALNGTLVRQIEAQIQDKCSALLAFYTPVSSASGAQNSTTMAARMSAFVDGVQRDQALLQQKQDSSTNDSRPNVQMEAYFTALLQTLRTMHEMVSKHLLGSQAQFDAATSKWAAAKCEAMGLKLSVLAMQLEHDTYTPATLPALALLRDYVSTAFVESRTERDASNRMLVAYQSIGSKFTELVREYGSVLEEIENRRWALEELRRDQAPTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMC9</accession>
    <name>A0A0D2UMC9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345320.1">
        <property type="nucleotide sequence ID" value="XM_004345270.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMC9"/>
    <dbReference type="FunCoup" id="A0A0D2UMC9">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UMC9"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMC9"/>
    <dbReference type="OMA" id="SHFHGKN"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="35161" checksum="428DA8438D0478DB" modified="2015-04-29" version="1">MSDTFNPAIPTTSNDGKSTGRFGYRTPAEEVVTELGIDLSDRVAIITGASSGLGQETARVLALKGARIILAIRNLEAGQKVAQEIQQSTGNTKIEAMLVDLTSLKSIKEFADTFLAKKLPLNLLVNNAGVMANPTRETTADGFEMQFGTNHLGHFYLTQLLTPALVAAAPSRVVAVSSLGHTFSPVVFDDINWEKSYDRWLAYGHSKTANALFALELNKRLSPKGVIAVSLHPGGAATNLSRHIPRDYAISQGWMNEDGTMNSVFKTVEQCSSTTVYCAIAPEVLEHGGAYFEDCNLGVPAPHASDPQAAAKLWEVSEKLISNALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMG9</accession>
    <name>A0A0D2UMG9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344226.1">
        <property type="nucleotide sequence ID" value="XM_004344176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMG9"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMG9"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53057" checksum="C0376FFFFC650724" modified="2015-04-29" version="1">MLSYDDMTERQREVYDYVKNEVVLMLSGARMNEAEAQAVVEGLKVNTKLIFLSLSANPIAAVTIADLLRVNKTIQNLFLQENQIGDADAVAIADALKVNTTLNDLDLKVNQIGDAGAVAIADALKLNMTLKKLRLDENQIGDAGAVAIADALKLNTTLARLLLVENQIGKAGAQAIAEALTVNTTVTELRLDKNQIGDAGAQAIAEALKVNTTLTELRLHQTQIGDVGAQAIAEALKVNTTLIDLQLSGNQIGDIGAQAIAEALKGNPTGITVDLNSNCIDRAFVQLVKQAQKTKNRGLYLSNDTQFNPLVFSLLPRLASTEDIQAVLGMLTSGLELENQSQSLPALPTEIAELIMDEAYYWQGVQHAKRMHGDQHYTLTVTVPRSVIGNSIRVKTIQVLREWKLCPDTISDCVFDLTVQDEQGAVRYECLVQPTFVDSNLLQLATIWPANHPILRQMREGWQVRVARSKSNEYVRFEALYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMR0</accession>
    <name>A0A0D2UMR0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344289.1">
        <property type="nucleotide sequence ID" value="XM_004344239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMR0"/>
    <dbReference type="InParanoid" id="A0A0D2UMR0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="69" mass="7500" checksum="F6215A9286A89DE6" modified="2015-04-29" version="1">MSEELNASVRFCGHEGCTSTEIVSVGFSEAAIEMLDVDNSEATNREIMASAALERIAKLTKIKKSHIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQL8</accession>
    <name>A0A0D2UQL8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343614.1">
        <property type="nucleotide sequence ID" value="XM_004343564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQL8"/>
    <dbReference type="STRING" id="595528.A0A0D2UQL8"/>
    <dbReference type="eggNOG" id="KOG0095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQL8"/>
    <dbReference type="OMA" id="LNVPRWV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQL8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="37842" checksum="BB6DE895652A9DF0" modified="2015-04-29" version="1">MPADASLLGSSSPSLRASTSSIATALHSPVSPVGSVPSNLLHTQAIAQFKVILVGDASAGKTSLLHRFIHGFMPEHTVATIGVDFDAREVFHPRTGQFVRIHLWDTAGQERYRTVTTSYYRADGCLLVYDLTSPKALASVRYWLDEVAEWAPSSIVTRVVGNKADLEDKLTQEQVGNIQAIETLATCQGATASRMSVAQNADAVDELFVNLIDAMLDQATASTAILATSPSSQRDIRSPSFSLHGRRDSLGAHSVASTLLESSSSASFSPPSGRRSPFQSLLALRKPSDSPGSASSTTTTSSSLSNPSMGSIESFVARSPSPTSARTEAARRKRKQAANLEFIEVRKSSRCCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQY1</accession>
    <name>A0A0D2UQY1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQY1"/>
    <dbReference type="STRING" id="595528.A0A0D2UQY1"/>
    <dbReference type="eggNOG" id="KOG2639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQY1"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQY1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="559"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1058" mass="112715" checksum="2E3D1F194E69B82C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG19</accession>
    <name>A0A0D2VG19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG19"/>
    <dbReference type="InParanoid" id="A0A0D2VG19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="124" mass="14115" checksum="F0BB60E5A3A6EDE4" modified="2015-04-29" version="1">MNIVPVTYSESRDAEAGGWPLVPLCPERQILPKMSRSGSGTNRGPIGNNEARATHAWRHHPIPLVFPRPVIHLPQMWRFNVVQVWNRYAPPRHISAFILTRGEGCEHDPGKTPKSKQRRTQPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGP5</accession>
    <name>A0A0D2VGP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGP5"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGP5"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1517" mass="166081" checksum="55CC629039EC3C54" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJQ0</accession>
    <name>A0A0D2VJQ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_001563</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2VJQ0">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJQ0"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJQ0"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJQ0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="472"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="690"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="890"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1363"/>
            <end position="1385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1385" mass="148664" checksum="E1134D5ABC2A2F92" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKK2</accession>
    <name>A0A0D2VKK2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKK2"/>
    <dbReference type="InParanoid" id="A0A0D2VKK2"/>
    <dbReference type="OMA" id="INTNACM"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKK2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="15594" checksum="FCA431852490A5F2" modified="2015-04-29" version="1">MDFAYGSLLGMMVLCYVPHTIKAILYKAITKRTPNNADPRNALNVADPVLQTEKAAILRRAQSCHYNLLENFAFFAAGVIAAKVAHVPTATINYYVAMHVLFRVAYVPLYLLISTNPASALRSIAFFGAAYASAMLMISAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKV7</accession>
    <name>A0A0D2VKV7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKV7"/>
    <dbReference type="FunCoup" id="A0A0D2VKV7">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VKV7"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKV7"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKV7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="474" mass="52724" checksum="BDC47F8692F329EA" modified="2015-04-29" version="1">MRPTTVRVSEMKDLTRIERIGAHSHIHGLGLNDALEPREVSDGMVGQLAARRAAGLILEIIRQGKIAGRAVLIAGQPGTGKTALAMAMAQALGADTPFTTISASEIFSLEMSKTEALTQAFRQSIGVRIKEESEIIEGEVVEIVIDRPATGAGQRRGKLTLKTTDMETLYELGQKMIESLTREKVQAGDVISIDKATGRITKLGRSYARVKEYDAMGPQTKFISCPEGELQRRKEVVHTVTLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVSEWREERKAELIPGVLFIDEVHMLDIECFSFLNRALESEMAPILIMATNRGITRIRGTNYKSPHGIPIDLLDRLMIITTTPYTETDIAQILRIRSEEESVTLSPDALRILTKIGTEASLRYAIQLITTANLVCRKRKATVVEVSDIKRVYKLFLDETRSAQYLNDFQDEYAFDKLMAEREQQKQAAAPSGEAMQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNI8</accession>
    <name>A0A0D2VNI8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNI8"/>
    <dbReference type="STRING" id="595528.A0A0D2VNI8"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNI8"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNI8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="450"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="768"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1054" mass="110602" checksum="274649DD3C10BB56" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ55</accession>
    <name>A0A0D2VQ55_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ55"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ55"/>
    <dbReference type="InParanoid" id="A0A0D2VQ55"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="64529" checksum="DD217A9E1461E3F5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQR4</accession>
    <name>A0A0D2VQR4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363628.1">
        <property type="nucleotide sequence ID" value="XM_004363571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQR4"/>
    <dbReference type="InParanoid" id="A0A0D2VQR4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="115" mass="12816" checksum="A24DD2EC90FA18C2" modified="2015-04-29" version="1">METLTMQMPRSPRPRSIVVQPIEPIALDKALSSPLFQELSSDCSALRLAVFSCPLVQQLAEIDPEIYDDIDECLADPAFIDELESLLSDPSAIRTLLDEYQDELSDEYGCLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRJ6</accession>
    <name>A0A0D2VRJ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRJ6"/>
    <dbReference type="eggNOG" id="ENOG502S7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRJ6"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRJ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="769"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1793" mass="194561" checksum="A17705EA5DA0FB73" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSI5</accession>
    <name>A0A0D2VSI5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347510.1">
        <property type="nucleotide sequence ID" value="XM_004347460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSI5"/>
    <dbReference type="STRING" id="595528.A0A0D2VSI5"/>
    <dbReference type="eggNOG" id="ENOG502QRPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSI5"/>
    <dbReference type="OMA" id="QRAIMTT"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSI5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="292"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="966" mass="103596" checksum="AA589732C7913E37" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTM1</accession>
    <name>A0A0D2VTM1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346909.1">
        <property type="nucleotide sequence ID" value="XM_004346859.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTM1"/>
    <dbReference type="InParanoid" id="A0A0D2VTM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="353" mass="37925" checksum="063F1EB9A7DD8057" modified="2015-04-29" version="1">MSETSTEMLVASTEIPVAPTQSMAAVLEDIPCTAPLDFVLPVVPYQLNALLDQLTPGALGFDPIQFARGIKVRTDNLTQTECLQLKHGSAFVFPNGGKNTKGLGVDVKRWRDGNRYKKAHNTATNIPTIKAMVYPPFYLGGLYKTLYQIDDQRVLVLYTKGSPAASGRKPATRTSPKAGKSQSLRKSSAAPAHPLTPSSSSESSSSDLDSDSVTTVDAPRIVGSDIHSFPSPSSSEELNVGAASARLARADNAHHDQSLGLGMDFANFPNAVLRSLPQAGDIGMPDFLNNVPSTASTIRYDVGAEAGNDRTADWVQLSSQDRAEVLADDMDDAPLRKMFSDEELLMLNIEGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUL8</accession>
    <name>A0A0D2VUL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUL8"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUL8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUL8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17575" checksum="DC13CC6D9DD59094" modified="2015-04-29" version="1">MTDIQSSGKMLQEANQPAHLSYENMTRRQRELYDKVKTPESDHIWFLDQQIGDAGAQAISEALKVNTTLTQFGVGTNQIGDAGATAIAEALKVNGKLYWAELEDNQIGDAGAQAIAEALRVNTTLKDLILYANRIGDAGAQALAEALKVNKTLTSLRCRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVR9</accession>
    <name>A0A0D2VVR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345607.2">
        <property type="nucleotide sequence ID" value="XM_004345557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVR9"/>
    <dbReference type="FunCoup" id="A0A0D2VVR9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VVR9"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVR9"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007764403" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="306"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="41204" checksum="597AC25C5B1B273F" modified="2015-04-29" version="1">MKVFQISAVVAALLVASSVGLDNGLGRTPQMGFNTWNHFGCNISEALIRSTVDVMVATGLSAVGYKYINLDDCWAVNRTAAGVIVADPVAFPSGIAALASYVHSKGMLFGLYSDAGTKTCAGRPGSVGYEKIDAQTYAAWGVDYLKYDNCNAPADQTPQVRYNAMRDALNATGRPIFYSMCDSIDDPSAWAKPVVNSWRTASDISDSWSSIMKIVDKNEPLWKIAGPGGWNDPDVLEVGNGGLSTTEYTSHFTLWALMKAPLIFGCDVTKMTNDTLRILTNTEVIEWNQDSLGIQGHRVKRGLLSEVWMAPLANGRFAVVLFNTDPLLSAHMTVTWAELGLTAGSKYTARDVWQHKNVGLYAGTFDAQVAPKGVVAVTLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYY2</accession>
    <name>A0A0D2VYY2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin alkali light chain 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343341.1">
        <property type="nucleotide sequence ID" value="XM_004343291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYY2"/>
    <dbReference type="FunCoup" id="A0A0D2VYY2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYY2"/>
    <dbReference type="eggNOG" id="KOG0030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYY2"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYY2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF49">
        <property type="entry name" value="FI08416P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="149" mass="16720" checksum="A847C5BB5A70EF50" modified="2015-04-29" version="1">MSKLSEDQIADYKETFLLFDKKGDNKIALSDVGRTLRSIGQNPLESDVKKICDEIDPTGQKRVAFEQFLPYITRPTKEPGNADDFIDGLRVFDKDGNGFMSAAELRHVLTSLGERLTDDEVDSLLVGVEIDKDGGINYEDFVKHITTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZE8</accession>
    <name>A0A0D2VZE8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZE8"/>
    <dbReference type="InParanoid" id="A0A0D2VZE8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="37447" checksum="E5DEED52DBFA415F" modified="2015-04-29" version="1">MLAAHHPQPALHDGSDAEHTDQKPAPAPQAQYSQAAQAMYMPQAYPYHFAHMAQQQLLPQHYQHHQQQQEQQQQQQQQQQQQQQQQQQQQQQQQHYAAIAAAAAAAQHGYNYHAYAYPYGYYAVQPQAAVAPPAAASPAAAPPAAASPAAATVPPADLAAATTPAKLRTLAVKFKTPRQTTRKAKSAAPAAPAAPAAPAAPAAPAAPAAPAAPAAPAAPAAPAAPAAIETALPSSSSRRLQPRSASGSDVDSPTNSEGDDVDSLQLGIEMAARRKLTHSAIERRRRDRINDRFRALRLAVPASTRASDGPAIASSKVSILQNAITYIETLRGQVSQLQQQLQLATSQTGPTNQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZY5</accession>
    <name>A0A0D2VZY5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343169.1">
        <property type="nucleotide sequence ID" value="XM_004343119.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZY5"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZY5"/>
    <dbReference type="OMA" id="DSQWQKT"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="2701"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2493"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2833" mass="303608" checksum="08620162DFA685F0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZY9</accession>
    <name>A0A0D2VZY9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343172.2">
        <property type="nucleotide sequence ID" value="XM_004343122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZY9"/>
    <dbReference type="STRING" id="595528.A0A0D2VZY9"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZY9"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZY9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="35021" checksum="44AF75530F733481" modified="2015-04-29" version="1">MAALAISRRMFTSLSAHSRALASLSATPSSAAAAARKAEEPQPAAYANRILPMNQVEQYNRDGFLVVPNLFTPAEKQQVFSWTDQIGALPETKGKWMQYFENKNGQRLLCRTENFLDYFPELDKLIRGKITDAVSDLLQEPALLFKEKVNFKLPHSSGFEPHQDAPAYTTFKQRLHLTAMIAVDKAVIDNGCLEVVRGEHTKGMLPHPGGVMEEWLVKKWEQEKKWEPVQVEAGTILFFGSFLPHRSGANNSDRSRRAHYITYNALSDGDFRAAYYADKRIKFPPQIERVPGVDYSAGASVYNVANPIDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1Y3</accession>
    <name>A0A0D2W1Y3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346401">
        <property type="protein sequence ID" value="KJE98367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1Y3"/>
    <dbReference type="InParanoid" id="A0A0D2W1Y3"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1Y3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="682" mass="76155" checksum="FE842AC130F05F7A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHN4</accession>
    <name>A0A0D2WHN4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365544.1">
        <property type="nucleotide sequence ID" value="XM_004365487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHN4"/>
    <dbReference type="FunCoup" id="A0A0D2WHN4">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHN4"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHN4"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHN4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="16595" checksum="24C5DCBEDE7FC739" modified="2015-04-29" version="1">MSTERTFIAVKPDGVQRGLVGEIIARFEKKGFRLVALKLVTASEELLKQHYADLAGKGFFNGLIAYMASGPVAAMVWEGKGVVKTGRKMLGATNPLDSEPGTIRGDYAIDVGRNICHGSDSVESATKEIALWFKAEELNAYTQTIRPQVYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI28</accession>
    <name>A0A0D2WI28_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI28"/>
    <dbReference type="InParanoid" id="A0A0D2WI28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="79" mass="8450" checksum="937BF2DB42AE3B50" modified="2015-04-29" version="1">MQDMPRAAQTIKQLASAARPLATSAESSTRLVVPPEIAAEFPVRGPAFDDFIRRTPPDVLKAALAHAQAVLEAASRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI54</accession>
    <name>A0A0D2WI54_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365078.1">
        <property type="nucleotide sequence ID" value="XM_004365021.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI54"/>
    <dbReference type="InParanoid" id="A0A0D2WI54"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="359" mass="39455" checksum="605FF21FD80F1FA7" modified="2015-04-29" version="1">MPAQLTPTLHAPEADNQGAAPFEAASLFAHARNNAIRVIRQHLTAEEKSAINTGHVYIYCGKKIERWTDNRLWSKAYSTKAGWLIYREFEFDPNNTNGRTKKRKAGGLIKKILSDPTPNSTLRLVFYTNHISAAEAEEVPTSPQIARRHSSSVIPSVAASMGGSYRQRRSSDSLSESDLETLHERDEQNHTNLFASSTLRPSRSEPTQADASDYQDYASIMAQLKSYQQRVGMLDRPAMFYDPAPVASTTFFQPMLGQFADARMTLATAANDMTFEQFLAQDYSSSSSASTLLSTSASMPAIDASTLTDSSTATCLTPFGNFFQPIPSVSTAEMVAFENNFPFGFSSLSSHNISGVSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI95</accession>
    <name>A0A0D2WI95_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI95"/>
    <dbReference type="STRING" id="595528.A0A0D2WI95"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI95"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI95"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13631">
        <property type="entry name" value="PBP2_Ct-PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="296" mass="31611" checksum="AEED9F626D241EB2" modified="2015-04-29" version="1">MPSVAFQGNPGAYSEIAAKTHFDTAPDVTTRPCETFEQVFDLVAAGQVDFGFCPIENTLSGNFLPVYDLLLRRDVSIVGEFIAHDEHCLIAAAGTALSDVKLVYSHPHVLDQCEAFLKTLPATHVATTDTAGACQLIKAQNQPGSAAIASTLAASISGLTIIKRGIEDDANSSTRYIAIAKQAANPPSHVNAKTSMSVALRNQPGALFRALAAFALRDLNISKIESRPSSRAGALHTSTRQWEYMYAIDVEANASQQVMINALSNLEEFATKVKVLGCYPIFVPRGTPSSLSPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIL1</accession>
    <name>A0A0D2WIL1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365990.1">
        <property type="nucleotide sequence ID" value="XM_004365933.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIL1"/>
    <dbReference type="STRING" id="595528.A0A0D2WIL1"/>
    <dbReference type="InParanoid" id="A0A0D2WIL1"/>
    <dbReference type="OrthoDB" id="8949373at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIL1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254402" description="PKD domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="6">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="840" mass="89080" checksum="AF088046F113BA79" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIR2</accession>
    <name>A0A0D2WIR2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365436.1">
        <property type="nucleotide sequence ID" value="XM_004365379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIR2"/>
    <dbReference type="InParanoid" id="A0A0D2WIR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="47416" checksum="D17CCEED741A99EF" modified="2015-04-29" version="1">MSGLVAAVRSAIVDNLFGTTAEPDNGTARSDGNDLPQDSQQFGGSSGRSSAYGLRSLPAVAYDHMEAPHHRGHHHAQHPHPHQSPANEAAPDEDQNPASTAGIQQHQHSSLTAIRDNHDADADADAATGWTQTSSEAVVDDDDDGYGDDGISHQEEDDLVLNSANQSKPSHIENDRDDKFKRAGNADETTVNASNDNEDEDDDDEASSDRSMHDDGAGVSASTQQLSEKRVPRKQRNSHSLPTRRTADRTTLLQQEPSPVPSVNASANNRHAADSASLARGGKFETVQYQQQQLQHVSVETLRGSMVDIRQMAGYKSRGKKRPAFFTPPAARQTHFDSSTVQVVHSDNVRISQRSRALASLHHRAPPRSLPASPLALQSADSDPLFRRHVRALRAIERQIRSEYTYSNVSAPNDQPLIDSLVDSVWGLWDKFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIS7</accession>
    <name>A0A0D2WIS7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIS7"/>
    <dbReference type="InParanoid" id="A0A0D2WIS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="351" mass="39145" checksum="5D15F61B9898DBAD" modified="2015-04-29" version="1">MRPSVANRAPVPLCTSQQRRIRRENRLLLLWASKGSSRLLALFKDGTIRAQLFGRTSAWLQAGLELLEEFDALLDQKGGGVEHGQPRSSSRRRWGACRCGSLRNNRECTDATLRGGEIDFWADIGPQERPRKPQIARSQQSRWVWELEHPLACATSNHLHTRACRALWIKALLCTGGQAGHHELGWLMISNVVIVARSAAVAAVLFALRSNPCTLSVCRVLGGGWNRVSVEGARLAQIAWQHGRKPSARDGSHEHDGCTRIECPCSRLKLEQRSAASLGGLAAAAAAAAFGRNRAQQHWRCVQRRGRRSKPRDANTRCADHRCGSLGARQPQHAQRKRVQRDQTEREDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK15</accession>
    <name>A0A0D2WK15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK15"/>
    <dbReference type="FunCoup" id="A0A0D2WK15">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK15"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK15"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="144" mass="15336" checksum="1238037D069A427B" modified="2015-04-29" version="1">MSGRGKKGAETASSAAANKKQKTRSTRAGLQFPVGRIHRMLRKGSYAERVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRINPRHLQLAIRNDEELNKLLAGVTIAQGGVLPNIHTVLLPKGESETDAAPVKKVKSGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLC9</accession>
    <name>A0A0D2WLC9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLC9"/>
    <dbReference type="STRING" id="595528.A0A0D2WLC9"/>
    <dbReference type="InParanoid" id="A0A0D2WLC9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.40">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033803">
        <property type="entry name" value="CBD-like_Golvesin-Xly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25275">
        <property type="entry name" value="Golvesin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266445" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="429"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1172" mass="121662" checksum="DBDDEDF1D762DCDA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLL8</accession>
    <name>A0A0D2WLL8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348804.1">
        <property type="nucleotide sequence ID" value="XM_004348754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLL8"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLL8"/>
    <dbReference type="OMA" id="INPTACH"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLL8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254559" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="67779" checksum="A0F6F00440010B96" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLQ9</accession>
    <name>A0A0D2WLQ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348881.2">
        <property type="nucleotide sequence ID" value="XM_004348831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLQ9"/>
    <dbReference type="STRING" id="595528.A0A0D2WLQ9"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLQ9"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254565" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="566"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="732" mass="78487" checksum="B9184B9FAA8ACA87" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLR3</accession>
    <name>A0A0D2WLR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLR3"/>
    <dbReference type="STRING" id="595528.A0A0D2WLR3"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLR3"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="370"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="82958" checksum="19EF84CF1152690D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMH2</accession>
    <name>A0A0D2WMH2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMH2"/>
    <dbReference type="STRING" id="595528.A0A0D2WMH2"/>
    <dbReference type="InParanoid" id="A0A0D2WMH2"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039110">
        <property type="entry name" value="KNL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16124">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16124:SF3">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="93414" checksum="FC71ABBDFFA62452" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMQ3</accession>
    <name>A0A0D2WMQ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorting nexin 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMQ3"/>
    <dbReference type="FunCoup" id="A0A0D2WMQ3">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMQ3"/>
    <dbReference type="InParanoid" id="A0A0D2WMQ3"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571:SF1">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="265"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70331" checksum="B1102CD5BF42A928" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMZ6</accession>
    <name>A0A0D2WMZ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMZ6"/>
    <dbReference type="STRING" id="595528.A0A0D2WMZ6"/>
    <dbReference type="InParanoid" id="A0A0D2WMZ6"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF110">
        <property type="entry name" value="FI17948P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="449"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="688" mass="73927" checksum="B5CC9B090DA8A2F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNG5</accession>
    <name>A0A0D2WNG5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363829.1">
        <property type="nucleotide sequence ID" value="XM_004363772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNG5"/>
    <dbReference type="STRING" id="595528.A0A0D2WNG5"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNG5"/>
    <dbReference type="OMA" id="HQTGSMS"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNG5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="510" mass="51466" checksum="2C43681068A0A194" modified="2015-04-29" version="1">MSAATVLVRDDAPTADATAEPVAIALESDGTLLLTKLAERFAGATGLRFHPEDAPDTFKTVRLENGALHAPEGAAWKPVFFVVRAESTPAVAAAAAAAAAAATTTTAAAAAPATATTTTADASSNGAASDGSAGGVKRKAEDEADDGPRKKENCYKCGGFGHIQDFCPSPSGSIDMEGAVECHLCKGKGHVKMRCPNSVPSNVCYLCQMPGHFARECPRGRDPYGLNRAPFGGDSRLCYRCQQPGHLSANCPRVARGEQSLSSCYKCGQEGHIAKDCNVCYHCKKTGHVAASCPDRPPGAPFSDRRDRDRPYDSRGYDSRTASGYGSGYGGYDRGYDRGYDDRDRDSRGGYGAPPPSRSYGGGSGYSSGGYGSGYGSSSGSYGGGYGSSTGYGSAAVGYGSSSGYGSSASGYGAPSSGYGAPSSGYGSSSQGSSQYGSGYGGYGQAGSSYGSSSSGYSAPASGSGYGAGAAPSSGYGAQGGAGAAPYTSGYGSAPSSQPGGYSNQTYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP20</accession>
    <name>A0A0D2WP20_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP20"/>
    <dbReference type="STRING" id="595528.A0A0D2WP20"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP20"/>
    <dbReference type="OMA" id="WFRSHRS"/>
    <dbReference type="OrthoDB" id="5972258at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="359"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53166" checksum="293AAAEA5CD655D2" modified="2015-04-29" version="1">MLSVRKIKRIGKTAFKFKFFATFKSATLKAQLGADLGDANVVWSRSNRTAATKEASWTFARDPDAARPGATIATIKWDETLELIDNKGEFDVKDYKISLEQPHGKDGKDKIVLATGTINIARMASLTALDRQETIALKPIHKKLSDVVLEVCFTCEFLKEGRATDDDMISTWSRTTSGPHDEHDDSASGEEDEKAESPGRKGSVFDNVVSFLSGDKSKEKGKDKEKDHEEKDKEHDKEEKEKEKEKSKAKDSPAKAPSSAPTSAPKIVIESSDSYSSERESSKKDKKDHSSALKEQLAEKDAEIDRCRQRISRLEDQASDMQEIIRSLNDKVATLTVALQSSQGEGQRSERQRKEMAALKDLNGWLMKLGDKGWIKLWRRRWFSCDGQGKISYYKENDDINEMGHIDIDAITNVRVQLDLMQDKNKATFVVSVPGRDYYLMAHDTANMQAWVSAIETLRALRSEIRQASSTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPL6</accession>
    <name>A0A0D2WPL6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348013.1">
        <property type="nucleotide sequence ID" value="XM_004347963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPL6"/>
    <dbReference type="InParanoid" id="A0A0D2WPL6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="170" mass="19331" checksum="6FC2B48654C9ACDF" modified="2015-04-29" version="1">MEWSSSSSHANPSNHYNANLTHERDQSVYGSMDARASSLLNTDDAGLATTLLTASITDAAAGISFSRNQWSLQMQEATEALEALQNQSRHYRQLISSMDLNHRKLDFRTAEFRYHAKLFEVEADKLRKEHELNSEETMQITLLLERWKREFEVERRRANKAAGGKSGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPR6</accession>
    <name>A0A0D2WPR6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPR6"/>
    <dbReference type="InParanoid" id="A0A0D2WPR6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="117" mass="12420" checksum="F5B1FCE49C1BF562" modified="2015-04-29" version="1">MKEDIDKSTQARENSPLSLVKQSSDAGMEQVLSQPNHAASPNMVERVVVMDHLDQRVEDVAGMVGIGDGLVVGARRAVFEQTDNGLISKVNGAAFGFPLVFAFAGLHVALVSLMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPY9</accession>
    <name>A0A0D2WPY9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPY9"/>
    <dbReference type="STRING" id="595528.A0A0D2WPY9"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPY9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPY9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF100">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="477"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="765"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="821" mass="89206" checksum="7E94C44A170D790C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ51</accession>
    <name>A0A0D2WQ51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348282.1">
        <property type="nucleotide sequence ID" value="XM_004348232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ51"/>
    <dbReference type="FunCoup" id="A0A0D2WQ51">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQ51"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ51"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="180" mass="20451" checksum="F964888AD281C13D" modified="2015-04-29" version="1">MPAYHSNFNELPGLRSLGNFAFLPLNSSVKGPAPRGDGSEDIVEEALKYFKANVFFKNFDIKGNADRVLIYLTLYITDCLQKLAKCPTKNDGLKAMNTMSLETFSLPGDKNGNFPLNGLYQLPEARADADTMRQYITQLRQEIGIRLCERVYKNGPADKWWMCFQKRRFLNKSLDGRNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR97</accession>
    <name>A0A0D2WR97_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR97"/>
    <dbReference type="STRING" id="595528.A0A0D2WR97"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR97"/>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="667" mass="69520" checksum="90FABFF2C252115F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRF1</accession>
    <name>A0A0D2WRF1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347283.1">
        <property type="nucleotide sequence ID" value="XM_004347233.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRF1"/>
    <dbReference type="STRING" id="595528.A0A0D2WRF1"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRF1"/>
    <dbReference type="OMA" id="HWAARHA"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRF1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="48917" checksum="EBCCEC3834459DFB" modified="2015-04-29" version="1">MRFDHPNNLLLRYHPSPIHTVLASAIVILPHPSEHSASSARSSMTSRIVAAASVPPETVELLHESLAHGADVNATDQYGVSPLHLACCSDSFLEILSLLLERGANIAARTSFSSTPLHWAARHASLQTAQRLVEAGADILARDRHGWLPLHDAAAAGSGEMVRFLLEQLRLQHAAVVVNGLVGQLKNNTSGNVVACMPSREEELAHLAPGLDPSVLKPEPDEDVVRSRLELERSESQQQLPECCLDAQKALPVVHSIREFCRCVGRTISDPMLGNPCCGGGDSRSEQGPLTARTSPVPHVDDRDMYGSTPLHVAAAFDKIATVRELVYSGGADVHALNHDGLTPLHKAVIAAPVVNSEASILVARELLLAGACAHARKLKKPPLGGQAPSSASANIIEAGSGGCAVAQTSPCEPSGTLNFAGPSCLHIAAMQGNVWMCRLLLECKVNPDVTFVGTHRGLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRH3</accession>
    <name>A0A0D2WRH3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346819.2">
        <property type="nucleotide sequence ID" value="XM_004346769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRH3"/>
    <dbReference type="STRING" id="595528.A0A0D2WRH3"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRH3"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="852"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="730"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1118" mass="121653" checksum="099C8D77874F64E7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRJ7</accession>
    <name>A0A0D2WRJ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347349.1">
        <property type="nucleotide sequence ID" value="XM_004347299.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRJ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WRJ7"/>
    <dbReference type="eggNOG" id="KOG2083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRJ7"/>
    <dbReference type="OMA" id="FRIKFAE"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRJ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="143"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="619"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="747"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="931" mass="101405" checksum="B2A5205BB540A8F8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRP9</accession>
    <name>A0A0D2WRP9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PX domain-containing GAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346915.1">
        <property type="nucleotide sequence ID" value="XM_004346865.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRP9"/>
    <dbReference type="eggNOG" id="KOG1449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRP9"/>
    <dbReference type="OrthoDB" id="5873004at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRP9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11835">
        <property type="entry name" value="SH3_ARHGAP32_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69360">
        <property type="entry name" value="Cell wall binding repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="267"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="425"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="642"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1396"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1674"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1831"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1708"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1674"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1855"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1876" mass="196582" checksum="4B515458FB7FDAF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRX5</accession>
    <name>A0A0D2WRX5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 35 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347072.2">
        <property type="nucleotide sequence ID" value="XM_004347022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRX5"/>
    <dbReference type="FunCoup" id="A0A0D2WRX5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRX5"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRX5"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="395" mass="42295" checksum="9ED3A323D3E5DBFF" modified="2015-04-29" version="1">MSDPSIRFGAFTIPIKYLSLAILVIQNSTLVLTMRYSRTSEGPMYLSSTAVVMTEAIKLLTCLVIIFFEENLSVAATLGLLHREIVAKPDETAKMGVPSFLYTLQNNLLFVAVSYLDAATFQVTYQLKIITTALFSVIMLGKRLTRAKWIALVVLMVGVALVQLPPPKATEELPARSENNGGVVPADAAGAAGRKLNGLELTADLPEQHLRRLLAAIPANEKESDAELAVAGDDAGAASGSFIGLMAVITACCSSGFAGVYFEKILKGTQASIWVRNVQLGLFGAIIGIIGAFYQDGAAIAENGFFQGYTTVVWLVILMQAFGGLLVAVVVKYADNILKGFATSVSIVVSSIISIFLFGFHPHMAWNVGAGFVLLSTYLYSLPDAPVDQIRRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSZ6</accession>
    <name>A0A0D2WSZ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSZ6"/>
    <dbReference type="STRING" id="595528.A0A0D2WSZ6"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSZ6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSZ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="265"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="530" mass="58474" checksum="43461E0D635A54B4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTC3</accession>
    <name>A0A0D2WTC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="4">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="4"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTC3"/>
    <dbReference type="STRING" id="595528.A0A0D2WTC3"/>
    <dbReference type="MEROPS" id="M38.980"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTC3"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTC3"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000007">
        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="80"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="417" mass="44557" checksum="FFE2FE26DBF549BC" modified="2015-04-29" version="1">MSTSNKTYKLCVHNAAQLVTVCSQGERMKRGKAMDEVAIVENGTVVIGHDGRVAYAGPAADAPATATDADMVVNAAGKCVLPGFVDGHTHPFAMKLAGATYMDIHKMGGGIGFTVQHTRASSEEELQKLLQGRLDRMVRAGTTCVEAKSGYGLETATEMKMLKVLHRASKSHPITICSTYLGAHSVPKGTPVADYTKNIVEEQLPELKRLMDAGEIAPTAIDVFFEKGVFEREDTTRILQAGKQLGLLLNFHGDELNFVGAGELGGELGARAISHLEEVSDAGIAAMAQREVFGTLLPTTAYVLRIKPPPARKLIDGNVPVALGSDFNPNAHCLAMPFVMNLACVTMRMTMNESLVAATINAAGSLGVAQDHGSIEVGKLGNLVLIDAPRWEHVVYELYDPPIETVFIKGQVAHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTP3</accession>
    <name>A0A0D2WTP3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345057.2">
        <property type="nucleotide sequence ID" value="XM_004345007.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTP3"/>
    <dbReference type="InParanoid" id="A0A0D2WTP3"/>
    <dbReference type="OrthoDB" id="4507at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTP3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254654" description="C2H2-type domain-containing protein" evidence="4">
        <location>
            <begin position="37"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="341" mass="37032" checksum="BB4881E32D1327FB" modified="2015-04-29" version="1">MMTGRPTPSTTASIRRCCLLLLIPATLLSLASLTAAKPCSHDGSRLARASLERLVGSRTDLFDWPPSCPLHPLRDVHFVSQHKRRMTSFSKHQCLVCGKGFDTAEHLDDHFDHRHRDLEIQSQPVCLADFCDVLGCYTQSIGQKPDCSNSSIHHLHFKCGSLFRSCLSSELSGSALTNQVNAYCQHLDCTPAALDQQGAGDFVLPKSAAPPKSPTLSRRRDLSRMQLIVGIATVVLIVAIAVVKFIERRRGRANPQWDSTGTFASAREQAKGLTTGTRARLGNSSSFASSSSRLGDAPAAKPSTAFSDTVGWLRQRQSQGQHQSQQSAVVSSSREPSDPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVR1</accession>
    <name>A0A0D2WVR1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial processing peptidase alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344327.1">
        <property type="nucleotide sequence ID" value="XM_004344277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVR1"/>
    <dbReference type="FunCoup" id="A0A0D2WVR1">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVR1"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVR1"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVR1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="297"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65220" checksum="4C4C56439FE1A564" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW69</accession>
    <name>A0A0D2WW69_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="24">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAOG_006964</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW69"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW69"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW69"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1336"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="434"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1488"/>
            <end position="1772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJE96683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1789" mass="190358" checksum="641F9425EF841A2D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWG9</accession>
    <name>A0A0D2WWG9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_010059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWG9"/>
    <dbReference type="InParanoid" id="A0A0D2WWG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="912"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1490"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1566"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1491"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1518"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1628" mass="175698" checksum="3ECD48FDD7E321FE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX40</accession>
    <name>A0A0D2WX40_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGC/AKT protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WX40"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX40"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="630"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="775"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1906"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1775"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1836"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1775"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1836"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1970" mass="210195" checksum="D4FB25EAAECC0AAB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXB6</accession>
    <name>A0A0D2WXB6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342978.1">
        <property type="nucleotide sequence ID" value="XM_004342928.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXB6"/>
    <dbReference type="FunCoup" id="A0A0D2WXB6">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXB6"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXB6"/>
    <dbReference type="OMA" id="YYYFGKK"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXB6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="311"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="604"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="838" mass="89113" checksum="1357A7606F6D2EBD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY13</accession>
    <name>A0A0D2WY13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_010190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY13"/>
    <dbReference type="InParanoid" id="A0A0D2WY13"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="314" mass="34419" checksum="E58A1DEF4DA20D25" modified="2015-04-29" version="1">MLMYAKMNQTQRELYDEVSSEPDTVILSDREIGDAEALAIAEALKVNTTVTMIHLLFNQIREVGARAVAETLKVNTRLTFLDLGWNHIGDAGAQAMAEALKVNTKLAFLVLSGNQIGDAGAQAIAEALKVNTTLTHLRLWHNEIGDAAVPSIVQALKVNKTLKTLDLDGNFLSRGAIDALTQTGNKGTTWKNMRVQPKKEPSPATSALNAATAASIEPQSPVTLATENQQLRSELAAKDQELADERQKLAAKNHELADERQKLAMKEQELAVKDQELADERQLRAAKEQELQKLLLGIADREDWIDVKSPADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYT0</accession>
    <name>A0A0D2WYT0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342466.1">
        <property type="nucleotide sequence ID" value="XM_004342417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYT0"/>
    <dbReference type="STRING" id="595528.A0A0D2WYT0"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYT0"/>
    <dbReference type="OrthoDB" id="90295at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="486" mass="50298" checksum="B4D9C39371DD1FA7" modified="2015-04-29" version="1">MTALALTPNTRLQEAIRSNDLAAVQLELQNGFDHAATILAVRLQRSAIAQYLVKAGVDPMPGLIAAVSTNDKQMLEVLLAAGANPNPTETGQSRAVLEVGLIHAHVALECVQLLLAAGANPNHWSAMRRPPLAISTGPDMVDITRAMLAAGADPNRTGSNGWSALMHAAQSGNVAQAGVLLDAGADPHIRADDGSSCLHIAVQSGHVGMVRFLLSRQAAAVDAQAFALRRVIDADDAITLGNLLRAGADPSTRFGRQETLLGRAAMAGATKVVELLLKHPSQDLADTKSMLGRTALMFAANTDLTWLLLQAGASVHTADARGWTALAYAAASNDSERISMLIEAGAEVNSAALDGKTALMIAASRGFAAAVSTLCHVGARVDLCDNSGDTALLAATSNRPGATVAVLVQLLIDAGANIHAVAADGATALIRQAIRRDNESIQVLLKAGAAATHADRTGRTALEYWPSCPSLKFLTAPVKPALASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D0</accession>
    <name>A0A0D2X0D0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cdc42 GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365293.1">
        <property type="nucleotide sequence ID" value="XM_004365236.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0D0"/>
    <dbReference type="eggNOG" id="KOG1449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0D0"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0D0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11835">
        <property type="entry name" value="SH3_ARHGAP32_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="WH2" evidence="7">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="656"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="927"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1286"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1385"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1548"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1620"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1415"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1434"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1512"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1551"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1635"/>
            <end position="1652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1661" mass="173453" checksum="5F23E13560FCFBFD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0G4</accession>
    <name>A0A0D2X0G4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0G4"/>
    <dbReference type="STRING" id="595528.A0A0D2X0G4"/>
    <dbReference type="eggNOG" id="ENOG502QYDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0G4"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0G4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="540" mass="61620" checksum="ACFE1E32802D0075" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X260</accession>
    <name>A0A0D2X260_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_009623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X260"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X260"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="860"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="956"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1419" mass="146452" checksum="D747D0DFD09166AF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X294</accession>
    <name>A0A0D2X294_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364022.1">
        <property type="nucleotide sequence ID" value="XM_004363965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X294"/>
    <dbReference type="eggNOG" id="ENOG502SC4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X294"/>
    <dbReference type="OMA" id="HLLIMAG"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X294"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="143" mass="15904" checksum="2CE8431F116B2EC5" modified="2015-04-29" version="1">MSVLTRFSSTLGSRAAIAGTQTALRRFAATHAAYAPNPERQIGDYPDFAPSSAQLKDPSLYEDAQERRNLKDTLHENDELYTVWVVDEKSPVSRSTALKHLLIMAGLLTGLYGLAKLYDAPSRKPTTQRELPFHEPNGFAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2M7</accession>
    <name>A0A0D2X2M7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363455.1">
        <property type="nucleotide sequence ID" value="XM_004363398.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2M7"/>
    <dbReference type="SMR" id="A0A0D2X2M7"/>
    <dbReference type="FunCoup" id="A0A0D2X2M7">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2M7"/>
    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2M7"/>
    <dbReference type="OMA" id="DLIFNWQ"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2M7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18927" checksum="D247AC7C9E501577" modified="2015-04-29" version="1">MIRGILVFNNHGKPRLSKFYQHYSEEMQQQIIRETFFLVSKRSDNVCNFLEGGTLIGGSDSKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILDEIVMGGMVLETNMTEILGAIDSQSKLEKQEAGLMVQARRATTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q8</accession>
    <name>A0A0D2X2Q8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAMK/CAMKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q8"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Q8"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Q8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="660"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125089" checksum="025FD78B0FD4D4A3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Z6</accession>
    <name>A0A0D2X2Z6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348042.1">
        <property type="nucleotide sequence ID" value="XM_004347992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Z6"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Z6"/>
    <dbReference type="InParanoid" id="A0A0D2X2Z6"/>
    <dbReference type="OMA" id="HLYEDIN"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Z6"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="370" mass="37932" checksum="A2BF6ACC6DD0845A" modified="2015-04-29" version="1">MTSSLLKDILITQREASGITLLADSAADPLGALLAAGARAVATRGRGVVLVAIDRAPQLLCASLGLTGITGQRPIVVDAFSDPLGWSSASRGNSSLCQTCVSNLTQLADTIAKAAAAAAGGAALSTVYIDSLATLCLHHSVGDVSRFLAALVSSNRGVASVVALVHQDVLAALSESAESALATLAYVASTTVTVQPGTASVDVHHRRKTGKVLRSNEAFSFTLAHELVTVPASELSTTGSAGSTAGASASAASSSSSSAAGKTKQPDPTANLTFNLSLNAAERQARQNVVLPYLKTEADKRAILRQDYPSASAPGTIAYADDTEPPRVHAARPAVASNIVFEPEVGVDELDDFGDEEDQEEEDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X305</accession>
    <name>A0A0D2X305_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348082.2">
        <property type="nucleotide sequence ID" value="XM_004348032.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X305"/>
    <dbReference type="InParanoid" id="A0A0D2X305"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X305"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31294">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31294:SF8">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 21-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255453" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1599"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1702"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1734"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1819"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1853"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="950"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1896" mass="194944" checksum="37643183CA0124BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X313</accession>
    <name>A0A0D2X313_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348114.1">
        <property type="nucleotide sequence ID" value="XM_004348064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X313"/>
    <dbReference type="InParanoid" id="A0A0D2X313"/>
    <dbReference type="OrthoDB" id="24786at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="68237" checksum="344B1B01E81F4337" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3H5</accession>
    <name>A0A0D2X3H5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3H5"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3H5"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3H5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="581"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1309" mass="137588" checksum="FE7C6D29C9CE8F66" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3K2</accession>
    <name>A0A0D2X3K2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3K2"/>
    <dbReference type="InParanoid" id="A0A0D2X3K2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266775" description="Secreted protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11387" checksum="198F83AE0923EB50" modified="2015-04-29" version="1">MAGLIPSEVLLHLLMLALLFLLFHPHKVAPPPPPNSQIQCWQLPCLRKPRSGRRINKTAPFPIIPIPIIPYHFLRLASPPLHVMTENAAASSITTRFCPRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3T2</accession>
    <name>A0A0D2X3T2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3T2"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3T2"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3T2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="298" mass="32700" checksum="482BE6D9CFDC41DB" modified="2015-04-29" version="1">MSQQQQQQPPRPTAAPPPAQQPKFYLGGLASMMAACCTHPLELIKVRLQTFQQKGNTQFLPTLKLVVRDSGVLGLYNGLSASLLRQATYSMMRFGSYDVIKKQLEDPSRAPLTVGYKITAGILAGAIGGLCGNPADVVNVRMQADGRLPVEQRRNYRHAFDGLRRMVTEEGAAALFKGVVPNLQRAVLMTAAQLATYDQTKQFLMEQYGCKDTVLTHLYASMASGFVATVVTQPVDVIKTRIMNSKTGEFAGPIDCLRRTLAGEGASALYKGFWPAYARLGPHTILTFIFLEKLKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Z6</accession>
    <name>A0A0D2X3Z6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346326.1">
        <property type="nucleotide sequence ID" value="XM_004346276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Z6"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3Z6"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3Z6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55763" checksum="009D11CC21E83390" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4G2</accession>
    <name>A0A0D2X4G2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345128.1">
        <property type="nucleotide sequence ID" value="XM_004345078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4G2"/>
    <dbReference type="FunCoup" id="A0A0D2X4G2">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4G2"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4G2"/>
    <dbReference type="OMA" id="PPAEKYW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4G2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="35317" checksum="FDA955A653D9174F" modified="2015-04-29" version="1">MSEAFKPVIPTTTNEGKSIGRFGYRTPAEEVVTELGIDLSDRVAIITGASSGLGKEAARVLALKGAHIIIAIRNLEAGQKVAQEIQQSTGNTKIEAMLVDLTSLKSIKEFADAFIAKKLPLNLLINNAGVMALPTRETTADGFEMQFGTNHIGHFYLTQLLTPALIAAAPSRVVVLSSMGHAFSPIMFDDVNWEKSYDAWRAYGQSKTANALFALELNKRLSPKGVIAVSLHPGGAMTNLGRHISREYMIANGWMNEDGTLHSIFKTVEQCSSTTVYCAIAPEVLEHGGAYFEDCNLSVPSPHASDPEAAAKLWEVSEKLISDALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H2</accession>
    <name>A0A0D2X4H2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H2"/>
    <dbReference type="InParanoid" id="A0A0D2X4H2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="121" mass="12872" checksum="6E396D22E8766703" modified="2015-04-29" version="1">MQLFERSNRNVPVRNWIAHASGLIRWTSCLKNTSLEAHPAPLSSPVRTQYGQQPPNDNSINELRARARTALVLKGLRSSVPKLLCAALTAAAAKVGAVRNAASDESAGASEDPAASSPNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4J4</accession>
    <name>A0A0D2X4J4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345276.1">
        <property type="nucleotide sequence ID" value="XM_004345226.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4J4"/>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="12">
        <location>
            <begin position="1459"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1814"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1212"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1805"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1813"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1834"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2073" mass="220144" checksum="230660C00CF0F8A8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4J9</accession>
    <name>A0A0D2X4J9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral sphingomyelinase activation associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345297.1">
        <property type="nucleotide sequence ID" value="XM_004345247.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4J9"/>
    <dbReference type="OMA" id="FDDAVIH"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4J9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1916"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="2087"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2545"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1216"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1833"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1849"/>
            <end position="1910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2815" mass="305652" checksum="75A7343DD3057544" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4K0</accession>
    <name>A0A0D2X4K0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345302.1">
        <property type="nucleotide sequence ID" value="XM_004345252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4K0"/>
    <dbReference type="InParanoid" id="A0A0D2X4K0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="669"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1116" mass="119491" checksum="1A274B8AE1EEB3EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Q0</accession>
    <name>A0A0D2X4Q0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Q0"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Q0"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Q0"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Q0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="117"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE96444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="345" mass="38012" checksum="4A82E57C526C97F5" modified="2015-04-29" version="1">MTRSSSSSLVHGTSRPTPILQRLLLLLLLLLLVVVVVVVPVAQASAAADPDKSSAPSPPSLKRPTAKDARYVAFALTHVEYEHGDAMGLVLALVCLTPFATLVGLATLLLFRRELHTATIALGIVLNEVLSWGLKRLIAQPRPTREQHHHHQEASALGKRAGGALLGTLQEMITADSEDARTAEAVAEAQVLSSTPQISTQFTEFGMPSSHAQFAFFVAVYLILFMYASRRHQAASFANPHWRHLISVLLLAGAALIAFARVYLWYHTSLQVVVGAFVGAAAAAAWHHITNRWLRPCFPHIQRWRIARYFYIRDSSHIPNILRFEYDAAVQESERRAREAASKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4R2</accession>
    <name>A0A0D2X4R2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4R2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4R2"/>
    <dbReference type="InParanoid" id="A0A0D2X4R2"/>
    <dbReference type="OrthoDB" id="6158172at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395681" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="5">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="24231" checksum="A2D764AEF4F93D33" modified="2015-04-29" version="1">MTPKGLAFGLLLLLFCVISYGQLAQAVNACDPGVCSCNGNSVNCIGRSLTTIPSAIPPNTRELSLSNNPLYSISASAFTGLTALTYLSLSDCYLTSIPSNAFADLPALISLFLSWNQITSFPADAFTGLTVLSALQLNSNNITSIPDGAFTDLTQLTYLSLLNNQITTVSANAFTGLTALTYLYLTNNLFTTVPPSVFAGLTALKTLMLSRNPITSISADAFTGLSALTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4W9</accession>
    <name>A0A0D2X4W9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343781.1">
        <property type="nucleotide sequence ID" value="XM_004343731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4W9"/>
    <dbReference type="InParanoid" id="A0A0D2X4W9"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="307" mass="31763" checksum="2A6CCA541EE36BBE" modified="2015-04-29" version="1">MLRKFVERVLSGTAKRAATPVTTQSASAARSSAATASASAKPKSLLEPTSATLPTTTTTTQNQNAPRQPASIRTTSYRDGPPSASSSSSSLASAGRVSLTSLPDASAAASATTTLGLPDAGKMNVLSNKAGSTSNMNDDIEAFQRMALPSSSAAAASSNVAQQQPPHHQGQRVANVEVRGIGVVTATSVAINPITLQPYHVHAVLFRAPPARSLHSGSVARKPQPQVIPKVDSRMVAKQQSPAAESSSALAETVSWTVPEVEGDVLRLDPSVEVTHFGTPRPAPEPRQSEDEDAAAFISRGGPAKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X518</accession>
    <name>A0A0D2X518_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343394.1">
        <property type="nucleotide sequence ID" value="XM_004343344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X518"/>
    <dbReference type="InParanoid" id="A0A0D2X518"/>
    <dbReference type="PhylomeDB" id="A0A0D2X518"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266822" evidence="1">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="166" mass="17809" checksum="90A70606158F7B0A" modified="2015-04-29" version="1">MWSLVITAALLLAAAGRGSADTCVATAGFNARMSSPISFYNVALTTCADSVDPCPAGYTSCVYKAHSPHGIEQYTLYCTHCVNITNPCCEGSERRPSDEYSGLCPLCAPVLEYCPEFVENGRMDGTTLICDAGYQCNGENTNGSNSCMYVQCRPNGTINRSCVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X539</accession>
    <name>A0A0D2X539_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343473.1">
        <property type="nucleotide sequence ID" value="XM_004343423.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X539"/>
    <dbReference type="FunCoup" id="A0A0D2X539">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X539"/>
    <dbReference type="InParanoid" id="A0A0D2X539"/>
    <dbReference type="OMA" id="ASFRTFH"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X539"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="18578" checksum="BF748450CAAD6D98" modified="2015-04-29" version="1">MLSTIARRAYGSHASAPAVSSGPILVSTATLDLIAQVNSGLPAQPPKSLAPTPTPEIAALRVKEKGSWKDLTIAERQALYDASFRTFHDNRKAKPRGAIYLGVGAGVGAGLLLFVLGRLVLARDAETPRTLTKEWKEARRQIAIRTASNPVYGESRATWQDTVFNMLKKPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5G4</accession>
    <name>A0A0D2X5G4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5G4"/>
    <dbReference type="STRING" id="595528.A0A0D2X5G4"/>
    <dbReference type="eggNOG" id="KOG1456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5G4"/>
    <dbReference type="OrthoDB" id="302770at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5G4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12424">
        <property type="entry name" value="RRM3_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="302"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="460" mass="49964" checksum="2EEE554E4878480C" modified="2015-04-29" version="1">MSQQQKHSRDSDEDDMPGKRVRLEHTDGSSYSVNVDPHNPPPSRVLHVRKLPDGISSPQLSSAISELGGVVSFVIMMPQKHQALIEMVSVSDAMTVIAHCAQHPVYLQGQQIMFNYSKSQELKRTSGEQPDEGNPAKILLFTVFNPIYPITCEVSHTSPSAYRLVSQARPLPQRRALITPHTTTSLKVRQNNDESWDYTGAVPLGPPAGGPPPPPGGHSQYGGRPDDRGRDNRGPPPSGVYDGGRHYGGPPPGQLPPPHHYDGGRGGYDMGPPPHHYNPSSPDSRGPPPQFASNNGPQGSSPVLMIYHINPQRMTCQSLFNLFCLYGNVLRVRILANRTDAALLQFDQAHAADTALANLNRAVIFGTSLEVTHSRNTYIAGAATAPIPGSPATLVDFSDSPHNRFTNQRAAMKNRISPPTRNVHFFGLGVGATEEHIRSIFTPAGIEEPESIKLFEKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I1</accession>
    <name>A0A0D2X5I1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343016.1">
        <property type="nucleotide sequence ID" value="XM_004342966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I1"/>
    <dbReference type="InParanoid" id="A0A0D2X5I1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="648"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="875" mass="95017" checksum="8A088BA36E584BC9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5S1</accession>
    <name>A0A0D2X5S1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346380">
        <property type="protein sequence ID" value="KJE98299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5S1"/>
    <dbReference type="InParanoid" id="A0A0D2X5S1"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5S1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="934" mass="103723" checksum="0D395EB982BE23C6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0W3</accession>
    <name>A0A0D2U0W3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFA2 Winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365320.1">
        <property type="nucleotide sequence ID" value="XM_004365263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0W3"/>
    <dbReference type="STRING" id="595528.A0A0D2U0W3"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0W3"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0W3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFA2 Winged helix" evidence="2">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="337" mass="37757" checksum="D6767F7F69DA6BA3" modified="2015-04-29" version="1">MDARSQAAESLARQREQFRRSAVASSAMLPTRPVPVMAGTTITPIGSLASMLQGSSAASSSSSSAAQQADQQQQQQQGQQGQRPGGLPSLLSSLTNNSEPRGGQFIRQAQQQRAAEVSSNLVRLCERIVTHLRDRHLARDDNAATEFSLDELLARVSERVLSPAELDDMRHRLEGNILINHVDGKFRYKPKYAVGSKDELLELLRSYYMQGLGGIKQSELLQCYREAADDVMQLQADNRIYVLKPTKGTEMILFYNDPRLRVDVDEEFKDLWSKIQLPLSVDAELRAAQLQPLKVALPNSVEEQNKAKKQTARKITKFTNTHLQNLDLTQDFKPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1X2</accession>
    <name>A0A0D2U1X2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicular integral-membrane protein VIP36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365592.1">
        <property type="nucleotide sequence ID" value="XM_004365535.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1X2"/>
    <dbReference type="FunCoup" id="A0A0D2U1X2">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U1X2"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1X2"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1X2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252250" evidence="7">
        <location>
            <begin position="26"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="333" mass="37332" checksum="591EB22A17BE03F9" modified="2015-04-29" version="1">MPLRMSSSWLATLAVAALALTVAHAQEPARQFTLSRPYLGAGMEIPYWEFGGHSVVSDEYIRLTPDRQSKQGYLWSRLPVLFDHWDLIVEFKVHGSGRKLFGDGMAFWYAKQPMTPGPVFGSVDFFSGLGLFFDTYSNHNGHHHHAHPYISAMIGDGTLHYDHDADGTLTELAGCEAQFRNKPYPTRFRVTYLNNVLQVFHDIDNERSWKECFTKSGVHLPSGYHLGFSAATGDVADAHDVITAQLTQLHGQPKQPQRPLQETRELRQTEVPFVAEAPLKRERVNDDHGDTIGSTLGSIALIFLGSLAVIALIVGGIVFYRSKQEQHKAKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U382</accession>
    <name>A0A0D2U382_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365917.2">
        <property type="nucleotide sequence ID" value="XM_004365860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U382"/>
    <dbReference type="eggNOG" id="KOG3945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U382"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="606" mass="64629" checksum="A485D9E5BB92597A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3A9</accession>
    <name>A0A0D2U3A9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365967.2">
        <property type="nucleotide sequence ID" value="XM_004365910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3A9"/>
    <dbReference type="FunCoup" id="A0A0D2U3A9">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3A9"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3A9"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3A9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="450" mass="49722" checksum="BE07297605B1297E" modified="2015-04-29" version="1">MASTVTSAAAAAAAAAVPSTTYTCITCRVAFRTADAQRDHYKADWHRYNLKRKVAEMPPLSAEQFGERVMSQNATAAATAQRAASTQQFNCDVCSKHFASQHTYATHIQSNKHKDAAAAAEARAASGEQPQAAAAASERKHNTQQHHKKDDGVARRKAEQPTAPTDAAASTSTTATATSNAEAAAAPENAKPTTEAATETAEDDEEEDLEAEYLARAVELSEEDCLFCSRKSASFEANMEHMAYDHSFFIPDMQYLVDLRGLIKYLGEKIGTGNICLYCNGKGRSFRSIGAVRKHMISKGHCMLKDDEELEFADYYDFRSTYPDFDPNNPDANADEEVDEQRLIALGTAVISEDDMELTLASGAKLGHRALRRYYKQHFSWQDSRDAETIGRLAANYRMLGYHDSSILHNGKTRAQLHQDKRIQQAQAQQSMKVGIKYNKIHTIVPQVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3F6</accession>
    <name>A0A0D2U3F6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366036.1">
        <property type="nucleotide sequence ID" value="XM_004365979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3F6"/>
    <dbReference type="InParanoid" id="A0A0D2U3F6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027917">
        <property type="entry name" value="MITRAC7/Phoenixin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15061">
        <property type="entry name" value="MITRAC7_Phoenixin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="144" mass="16308" checksum="3BDDDDA24B77584E" modified="2015-04-29" version="1">MGFSFDGPSRPAGMLTARSRSRLFLLAMLGAMGMALYSVAGRPMMRSDEYRRAQRTNREAMQARDRDFRPDPSSPEEQARVAEVLERKRLMSQLAQKREAAALSQAANDAGRQQEARRIAREQQQQQQQQSQGQSQGQDQRPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3G0</accession>
    <name>A0A0D2U3G0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366042.1">
        <property type="nucleotide sequence ID" value="XM_004365985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3G0"/>
    <dbReference type="FunCoup" id="A0A0D2U3G0">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3G0"/>
    <dbReference type="MEROPS" id="A01.068"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3G0"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3G0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000149">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252292" evidence="10">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="62"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="40106" checksum="5079B13F299123C5" modified="2015-04-29" version="1">MQKLLVITLLAALIATAAGASIKLRKFESARRSLANVGNFIESRYLGVGAIEPQHNYQDAQYYGDITIGTPGQKFTVVFDTGSANLWVPSKKCPVTDIACQLHNKYDSTKSSTYKVNGTSFAIQYGSGKLSGFLSTDSVSFAGLTVTGQTFAEATAEPGLSFVAAKFDGILGLGFPQIAVDGVTPVWNNAILQGVAAAPLFGFWLNRDPTAADGGEIDFGAIDDSHYTGPILYTPVTRQGYWQFALGAVTVSGKNYCASGCQAIADSGTSLLVGPTDAVTAIAAAAGATKNIAGEYTLDCSKIASLPNLVFTISGQQFALTGADYVLKITSGSTTECLLGLMSMDLSAEGIQWILGDVFIGKFYTVFDFNGNAPRVGFATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3V4</accession>
    <name>A0A0D2U3V4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">PAP/25A associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349811.2">
        <property type="nucleotide sequence ID" value="XM_004349761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3V4"/>
    <dbReference type="STRING" id="595528.A0A0D2U3V4"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3V4"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="378"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="612"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="711" mass="75732" checksum="75C79F6066DF466D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3X4</accession>
    <name>A0A0D2U3X4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3X4"/>
    <dbReference type="STRING" id="595528.A0A0D2U3X4"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3X4"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3X4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050433">
        <property type="entry name" value="Myc_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45851">
        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="619"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="72805" checksum="19AC1C9CF07E0488" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5L7</accession>
    <name>A0A0D2U5L7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anti-silencing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5L7"/>
    <dbReference type="FunCoup" id="A0A0D2U5L7">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U5L7"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5L7"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5L7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268325" evidence="7">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="247" mass="27579" checksum="63860C5F4254FDAD" modified="2015-04-29" version="1">MLLFILRFIILKSNQSTIIHQKHSNTTSIRSSAVFVPSSERKTNMALVNVVNIVVLDNPTQFLNPFQFEISFECISALKEDLEWKIIYVGSAESEDYDQVLDSILVGPVPIGLNRFVFQADPPNTERIPDGDAVGVTVVLITCSYRGQEFIRVGYYVNNDYVDTELRENPPSRPDYTLMYRNILASKPRVTRIPIEWDPVETLESGLDGVELSSEALMMAATPSSSGIEETEGFPQASMMVGAEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5U1</accession>
    <name>A0A0D2U5U1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurofibromatosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364674.2">
        <property type="nucleotide sequence ID" value="XM_004364617.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U5U1"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5U1"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5U1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2817"/>
            <end position="2837"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="1364"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1633"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2538"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1648"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2545"/>
            <end position="2567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2982" mass="323774" checksum="AE12C73410289904" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7T9</accession>
    <name>A0A0D2U7T9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349075.2">
        <property type="nucleotide sequence ID" value="XM_004349025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7T9"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7T9"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7T9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="224"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="559" mass="62187" checksum="CDCA15F65C0AD925" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9H0</accession>
    <name>A0A0D2U9H0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348625.1">
        <property type="nucleotide sequence ID" value="XM_004348575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9H0"/>
    <dbReference type="InParanoid" id="A0A0D2U9H0"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9H0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="267" mass="28010" checksum="9F312E30C4AFB2AC" modified="2015-04-29" version="1">MHRSSSSSSSSCVVARVGRGAAVLALATACFAVCSVQAVVNPKLLVAFYPGSTDCSTLGANDTTPMIVTSSTCYPGATESDYWTLIAALDSGTGTYRQFQLLAGCPSGCNAGDCTTNISGAEFSEYCSSTNFASADTASVKVYVVPPPTASAPTRQIQFFSDSHCEDPTTFVNIQSNQLFTCVAASGKRYGLTNVEIVDDDAQIALMMGCNSNCSSCETNYIGQFNHCHTVNSLHFVVTNAAGLLQVPTLFALLATSMLGLFVSKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE06</accession>
    <name>A0A0D2UE06_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxidase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347971.1">
        <property type="nucleotide sequence ID" value="XM_004347921.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE06"/>
    <dbReference type="STRING" id="595528.A0A0D2UE06"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE06"/>
    <dbReference type="OMA" id="EWPATHM"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="34513" checksum="CA9F5E6C52AD82D0" modified="2015-04-29" version="1">MAAIANASRRLFSSLAANSRALSSVSAAAPAAAAAIQTPASYANKILGMNEVNQYNRDGFLVVPNLFTPIEKKKIFEWTDQISALPETKGKWMQYFENKNGQRLLCRTENFLDYFPELDQLIRGKITDAVSDLLQEPALLYKEKINFKLPHSSGFEPHQDAPAYTTFKQRLHLTAMIAADKAVIENGCLEVVRGEHTKGMLPHPGGIMEEWLVKKWEQEKKWEPVQVEAGTILFFGSFLPHRSGPNVSDRSRRAYYLTYNALSDGDFRSAYYADKRIQFPPQIERVAGVDYSAGASVYNVANPIDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEZ3</accession>
    <name>A0A0D2UEZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEZ3"/>
    <dbReference type="InParanoid" id="A0A0D2UEZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="17352" checksum="445776390F4D0613" modified="2015-04-29" version="1">MPVQHLPASNLSDNSKLTSQPSSIAALDTSQPHHTFTTMSQEVPQQAYVAFDHARISSSNLNSSVVVEYYAGPTAAEHFASAPLLQGHSSAFSDDEDTVELSDDSSDELHAHEESKNNNDNDKEFGSARSPSKFAAILQVLQVLQVLQVRTKQLGGAACQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF01</accession>
    <name>A0A0D2UF01_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF01"/>
    <dbReference type="FunCoup" id="A0A0D2UF01">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UF01"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF01"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000509">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="617" mass="66095" checksum="96A3345715A6A85C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFJ9</accession>
    <name>A0A0D2UFJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFJ9"/>
    <dbReference type="FunCoup" id="A0A0D2UFJ9">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UFJ9"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFJ9"/>
    <dbReference type="OMA" id="EPGWLVN"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="230" mass="24658" checksum="3E69D460F31EA94F" modified="2015-04-29" version="1">MSSVVVNLGRKPLSAKSLASLPRITLTSLKPIAGTNKERKRIGRGPGSGFGKNGGTGDAGQNKKEGHSRPGFEGGAMPFYRKVPKQSPVLAEVNIHQISKLIQTGFIKPSEPITIKTLHDVGLVKDFQNGVKLLATGAASLRSPIEIAVTRASEAAVASIERAGGKVTTVFYNQRGLRGLVHPERFEPTPPPSGFPVKNKHIQYYKNAQHRGQYAPALQLAQARRSIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFS6</accession>
    <name>A0A0D2UFS6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFS6"/>
    <dbReference type="InParanoid" id="A0A0D2UFS6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="485" mass="54563" checksum="8E9B2404E2E177F2" modified="2015-04-29" version="1">MYKKKRRGARGDFRRSLDEPQKSGMKTGRVDLCGLLSPFPCDRSSIAPTNARTRARTHRAPHLHKMSVPAPENPATTWSPILTVTFVVDAKPSPADQTLQLELPPRTDRLMVRHVTAALPGFIPPELLTSPETPIIQLVTFDQDNIMRVQHDNTAVKTSQLMAVVSFRCSKNNHDRRSYEFFEGRKTCKSCTDRNARYRKKATAKKVALKDQQSSEPAEEAARNAPTTRLTELAHTRLMFNDPQSLEDFWESQQSTIDLRLKHDYCPGQSRRSQVRDEMDSASPVLSAHAPHDAEDDLAASSVSSVPEAAQLIHADEVSESIDEDDLNSHPGTSPVYLTQDERNQLNLWFENRPVLCSRTQRFWCFNHRSTSSKEPSPASSMIQDRFLESLDFTHPMHTHRLDNDFRVQPGLGQGSCTFAISKSVLVQVDGNNLRFVGWKVSLAGQHDARCTKGDFAHKQLTHRIFKHGHLISHPSAATRAKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJM1</accession>
    <name>A0A0D2UJM1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346441.2">
        <property type="nucleotide sequence ID" value="XM_004346391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJM1"/>
    <dbReference type="InParanoid" id="A0A0D2UJM1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="314" mass="34540" checksum="472921119E87D3C2" modified="2015-04-29" version="1">MTEPVVRTYLRKPWKHSASPVHLASNGHLIHAIHESAKASAPATPSPRQDEMDASFILARKIQTQNSVADPLLLLLDLPPASVERPGTPVPMARSTTTDPLCAQVQPGDFSSDSSCQTNTTANSVELDFLIASPGSSSDETVDPEHIRATPPVVVAEPCFLTTPTPRWLPTLEFPPTPDSSRGLSPDWLVSGGPTQAQNNRQTYAAKKSTARAKRQWTERSPVSPPRSREQVKSGQIDWSPPPAQPAALQLDRDESPDVLQYKRMPKKPRISNTPIDHSQDKEYMAFAEAATKMFAEIEQTELEMTFDVSDWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULC8</accession>
    <name>A0A0D2ULC8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345049.1">
        <property type="nucleotide sequence ID" value="XM_004344999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULC8"/>
    <dbReference type="InParanoid" id="A0A0D2ULC8"/>
    <dbReference type="OMA" id="TMVPVST"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="208" mass="22610" checksum="18AE702FE1067B71" modified="2015-04-29" version="1">MHETMTVSMVLVMMVVVVMMIVLVVLVVLVVLVVPVMLLVPVVLVMLVVFVMLVVPVVLVVLVVLVMLVMLVMLIMFIMLVVPIMLIVRVRLVVPVVLVVLVMPVMLVVFVRVIPFMTLVVLLVLVVLVVLVVLVVLVMLVMLGMLVVLLFGLDLAVAAALGATAGLTLNATIAATVRTTVCWRSARLITEGVLKRRVPVDAVRRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMR3</accession>
    <name>A0A0D2UMR3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344293.2">
        <property type="nucleotide sequence ID" value="XM_004344243.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMR3"/>
    <dbReference type="STRING" id="595528.A0A0D2UMR3"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMR3"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMR3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="182"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="383" mass="42835" checksum="6DAC5E65968B69CC" modified="2015-04-29" version="1">MTSYADRGAKPEVGRYLAFDHITFWVGNAKQAAAYYCLRFGFKPIAYAGLETGSREVVSHVVALNSVVFVFQSALNPSDRAMGDHLVLHGDGVKDVAFLVEDARGIYEKAIQRGGKSVRAPYELTDANGTVVLATVQTYGDTTHTFVDRTNHKGGANFLPGFAKPVFVDPLLDNLPATHIEFVDHCVGNQPDREMESVASWYERVLQFHRFWSVDDTQMHTEYSALRSIVVADYDEKVKMPINEPAAGKKKSQIQEYVDYYGGAGVQHIALRTEDVIASVSALTKRGVEFLSVPDTYYENLRIRLASASIKVAENLDELQKLKILIDFDENGYLLQIFTKPLEDRPTLFIEIIQRRNHQGFGAGNFKSLFEAIEAEQGRRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNW7</accession>
    <name>A0A0D2UNW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase m2 polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343661.1">
        <property type="nucleotide sequence ID" value="XM_004343611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNW7"/>
    <dbReference type="FunCoup" id="A0A0D2UNW7">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UNW7"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNW7"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="352" mass="40259" checksum="59EF032EBFFA7AC4" modified="2015-04-29" version="1">MTTNGHSSTTESILARTAEEALVNGLSKLELDEPLLKPNPHRFVLFPIQYHDVWKMYKKAEASFWTAEEVDLSKDLNDWDKLKSEERHFISHVLAFFAASDGIVNENLLLRFSTEVQIPEVRSFYCFQIAIENIHSEMYSLLIDMYIKDSAEREKLFNAIETLPCVAKKAQWALRWISDRRSTFAHRLIAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACMLFGLLNNRPSNADVLAIIKDAVAIEQEFLTDALPVALIGMNGGLMKTYIEFVADRLLVALGQEKHYKVENPFDFMDLISLQGKTNFFERRVGEYQKPGVMSTKDEHRFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPQ5</accession>
    <name>A0A0D2UPQ5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE96981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPQ5"/>
    <dbReference type="InParanoid" id="A0A0D2UPQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="233" mass="24715" checksum="2129C97E6662BA15" modified="2015-04-29" version="1">MPLNPTTTGRDDEQMVGSQRMPQGSINKGLTGQERSGYTDTDASQQRYGGQQGDRYGQDQSGSDRYGQGQQGYGQQSQQGYNQGQQGQQGYNQGQQGYNQRQQGGDRYGESQIGGEFNRTNESERTTTRSTDQTSSRFTSDVGGGSSDRCGMPDRSGMSDRSGMSSDRVGDDRMGGRVNEQASDQGGIFGRVGAGISNVGNSLSDTGNKIGGMFGSTNTPSTGSGLSGGQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQU2</accession>
    <name>A0A0D2UQU2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorcin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343120.1">
        <property type="nucleotide sequence ID" value="XM_004343070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQU2"/>
    <dbReference type="STRING" id="595528.A0A0D2UQU2"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQU2"/>
    <dbReference type="OMA" id="LNQFIYC"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16181">
        <property type="entry name" value="EFh_PEF_Group_II_sorcin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="205" mass="23266" checksum="899D94EE37EEEADB" modified="2015-04-29" version="1">MAYFPPQGGYPGAPGGYGAPSAGYGAPGTGYGYPPAVDPLFGYFSAVAGRDGQISPEELQRCLQGAGYGNGWETFSLETCRLMIGMLDRDGNFQMGFEEFKELWNSLNQWKHTYYTVDRDRSGTVNEQELHQAIRTYGYNLSPEAFRVVFKRYARREQTIITFDDFIAVSVRLRCLSENFRRRDTHQNGTAMLSYDEFIRFSFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URV4</accession>
    <name>A0A0D2URV4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342869.1">
        <property type="nucleotide sequence ID" value="XM_004342820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URV4"/>
    <dbReference type="STRING" id="595528.A0A0D2URV4"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URV4"/>
    <dbReference type="OMA" id="GILECEM"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="214"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="374" mass="39166" checksum="A9E77E502C515BC5" modified="2015-04-29" version="1">MRLATLTAPAATHRLGHLLLRPTIAASASAASATTTATATATATARRSISCSGPAKPNLTRLGLGSRPASLSSVSAAAPPAAASLVKPYSPRSIITWPTVALAAAAAAAPSALKRKQSSSQSSFMSTSLATCSAAELLAAADRVVADAVQHMSGIVTTGREVTHSGRWLRSGVVKYTVPIVAQQEGGSSSSSTSSSASARSWEYAERTTRLADVGVDGVDIIALIGSSKNPVRGSEKSLVLVLNYRPPVGRPSLEFPAGLIDKGETPSQAALRELKEETGFTGVIREISKDINVDPWKSTENFHLVTMDIDSDDPNNATLKQELDEDENLVPIIVPVKNLLQTIIRYKELHGVAIESKLYGFAKALELASSASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT45</accession>
    <name>A0A0D2UT45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT45"/>
    <dbReference type="STRING" id="595528.A0A0D2UT45"/>
    <dbReference type="InParanoid" id="A0A0D2UT45"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT45"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="447"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="690" mass="73689" checksum="62074178050A5977" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT70</accession>
    <name>A0A0D2UT70_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342766.1">
        <property type="nucleotide sequence ID" value="XM_004342717.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT70"/>
    <dbReference type="FunCoup" id="A0A0D2UT70">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UT70"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UT70"/>
    <dbReference type="OMA" id="IGGHAMS"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009566">
        <property type="entry name" value="PRK13020.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="213" mass="22977" checksum="ED2A6A8FA3F4DE2E" modified="2015-04-29" version="1">MFTGIVRGLCPIRSALLTGGILRLQVELPAGDASAGIELGASIAINGTCLTVVHFDAATRIVDFDVIQESLSRTNLGSLQAGSRVNMERAMKFGDEIGGHQVFGHVDATGTIERVVATEGNRDVYFRFFEEWSKFVVPKGWIAVDGISLTIVHVAPGLLSVSLIPETLARTTLGFKNEGDIVNLEFDPQAKLVVLTMERLLPGMLERQLAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHF9</accession>
    <name>A0A0D2VHF9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365746.2">
        <property type="nucleotide sequence ID" value="XM_004365689.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHF9"/>
    <dbReference type="STRING" id="595528.A0A0D2VHF9"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHF9"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHF9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="248" mass="27227" checksum="F78A79C96E249842" modified="2015-04-29" version="1">MASSVAALEPFLILARTAKGAACASLINQAIEAQGTFVFSELLATPAVKELEGTAHQQSLELLKLFAYGSYADYTANPSRFPPLSATQQTKLRLLSIVSLASDCKTIPYAKLLAVLALDNVRELEDIIIEGIYSNVLKASLNQQHQHVRIEFAIGRDIASNAQLDSMIQTLGAWCQQCETLLTNIHSNIASANRQKTSAMDEQVALQERIAIQKQAFTSQMSHKLMDGHGLRDFRSGYGTDKKGRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI86</accession>
    <name>A0A0D2VI86_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carnitine/acylcarnitine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365955.2">
        <property type="nucleotide sequence ID" value="XM_004365898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI86"/>
    <dbReference type="FunCoup" id="A0A0D2VI86">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI86"/>
    <dbReference type="InParanoid" id="A0A0D2VI86"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI86"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="119"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="325" mass="35673" checksum="3F5E830CC700F1BD" modified="2015-04-29" version="1">MSDLSDHGGPPHHSHLPHAEPRFSKMDHFISGSFAGIAQSLIGHPFDTIKVRLQTQSVTNPLFKGPYDCLQQTIRKEGVRALFKGMSSPLVASIVFNSILFGTFEEFKSRLSNPLTGQLSTANFVLSCTATGALESLLYCPLELVKARLQVHMQASAASSAASAATTTATTTTTATQLGPMGMLREVVQQRGIRGLFIGLNVTMLRECPGNVMYFGAYEMFKTHYPATRPETERIIMSGGLTGMLYWTFIYPIDLLKSKVQCDDLQSPRYRGLVHCFRVSLQESGWRGLFVGLSPCILRAFPANGAAFVAFEFSKSFLRSQAEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLZ7</accession>
    <name>A0A0D2VLZ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLZ7"/>
    <dbReference type="InParanoid" id="A0A0D2VLZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="70" mass="7713" checksum="5C54B3FDE3CEF8F3" modified="2015-04-29" version="1">MDNLNATDFRMDLPCRQQQKQQQQQQCACLLSVRGGRGSILNAWHSDSFIGSAAPFGTFGSSLPPCRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNI0</accession>
    <name>A0A0D2VNI0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002942</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363781.1">
        <property type="nucleotide sequence ID" value="XM_004363724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNI0"/>
    <dbReference type="FunCoup" id="A0A0D2VNI0">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNI0"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNI0"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNI0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254370" description="ribonuclease Z" evidence="12">
        <location>
            <begin position="27"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="880"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1169" mass="124516" checksum="A3838DA863FCE22F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP65</accession>
    <name>A0A0D2VP65_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364048.1">
        <property type="nucleotide sequence ID" value="XM_004363991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP65"/>
    <dbReference type="InParanoid" id="A0A0D2VP65"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="73" mass="7712" checksum="6C91C2FF56ABFCC6" modified="2015-04-29" version="1">MISSSVLDLGHKIIVSALVLTTIVSLAEVSGKGYTSLRRSYGVMQQQKAEEAAREAAAKAGEGFVTESTSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP75</accession>
    <name>A0A0D2VP75_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP75"/>
    <dbReference type="InParanoid" id="A0A0D2VP75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="237" mass="26953" checksum="40409A681BBA1059" modified="2015-04-29" version="1">MQLKEVMATSPMSASESSSLASEIEQTAHDGANFRVDVKALPTSVALLDEEHAKLTKTQVSTAMSSELATMRSTLANWKERLDELEATAQYRQECQLISEVAFRVDRRLVQFVICNSSEREEELGIVYSLKMLLRQSSCWEDLQPAERARSLAINEYLVEKTFSKFNLLTPFKLLKGMRLDYTQAVPPKDPDYLNSLIQKHRAEDPQWLLDQFSVIVDLYCCSDEALSSLLQAYVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQW8</accession>
    <name>A0A0D2VQW8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347816.1">
        <property type="nucleotide sequence ID" value="XM_004347766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQW8"/>
    <dbReference type="STRING" id="595528.A0A0D2VQW8"/>
    <dbReference type="eggNOG" id="KOG4538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQW8"/>
    <dbReference type="OMA" id="RKWKQPK"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="183" mass="19804" checksum="D63E5741EC3B3568" modified="2015-04-29" version="1">MGRPRKVAAAPAAPAAAAVKPAPVAPAPVAAPAPVPVAAPAAPAVAPAETAPAKPRKAKPAIDPRNNAAPNPLDAGVVGKAKSGRHWKTRQTQRASARMNVPSARVGWAKLMERKQEKLPMREQERQLQEQIDQAKQAEREARIAKQKRRAENERKSEVVQKITNTSKIKRMSKAQLRTLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS75</accession>
    <name>A0A0D2VS75_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_004620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS75"/>
    <dbReference type="STRING" id="595528.A0A0D2VS75"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS75"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE93902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="738" mass="75138" checksum="B3800BC449E0C42C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTQ4</accession>
    <name>A0A0D2VTQ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTQ4"/>
    <dbReference type="FunCoup" id="A0A0D2VTQ4">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTQ4"/>
    <dbReference type="eggNOG" id="KOG1582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTQ4"/>
    <dbReference type="OrthoDB" id="438495at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTQ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="403" mass="44597" checksum="EF8B81C375729171" modified="2015-04-29" version="1">MHKQQQQQQQQQQQQQQQQQQQGKTSGAELESVRSISGASNGSTNSSPGSGMMMSNQTTTTNAASSVASEPFVLLGIHMDRQPRTVQFVAAASLVIFFFVIYGSILETIFRDPGYAQYGYHMTLTLFICYSIFSAVEITYKGGKVFKAPLGGYCLIALLTVITMTLSNVALAYLNFPTQIIFKSCKLIPVMIGGILIQQKRYELLDFACASLMTLGLILFTLADVQVSPSFSFIGVGLISIALCADAVIGNVQEKYMKLYKCSNAEMVFFSYSIGACYLTLFMLVTGELYHGTIYALAHPRETYGLTVLLSISGYLGIEYVLLLVRHFGALLAVAVTTFRKAFTMILSFALFPKPFTWNYVFASLLVFAGGFLNIYAKQPEVVYAWIYRWTGITIGRSRPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU07</accession>
    <name>A0A0D2VU07_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346085.1">
        <property type="nucleotide sequence ID" value="XM_004346035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU07"/>
    <dbReference type="InParanoid" id="A0A0D2VU07"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="804" mass="87602" checksum="B7FA443E88A3319E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV79</accession>
    <name>A0A0D2VV79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV79"/>
    <dbReference type="STRING" id="595528.A0A0D2VV79"/>
    <dbReference type="eggNOG" id="KOG3549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV79"/>
    <dbReference type="OrthoDB" id="409749at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57073" checksum="0DA428E39532C3B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWE0</accession>
    <name>A0A0D2VWE0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345033.1">
        <property type="nucleotide sequence ID" value="XM_004344983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWE0"/>
    <dbReference type="InParanoid" id="A0A0D2VWE0"/>
    <dbReference type="OMA" id="WHIDEAR"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="601" mass="66904" checksum="A7E39727F43B1DA6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX42</accession>
    <name>A0A0D2VX42_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX42"/>
    <dbReference type="InParanoid" id="A0A0D2VX42"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="51" mass="5714" checksum="D937FC4D580B2BE1" modified="2015-04-29" version="1">MNASNHHKLEQQIDTQVRGEIVCADDSPLEVSKRHDSLEFITITMTTDSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXH6</accession>
    <name>A0A0D2VXH6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleiotropic regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344321.1">
        <property type="nucleotide sequence ID" value="XM_004344271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXH6"/>
    <dbReference type="FunCoup" id="A0A0D2VXH6">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VXH6"/>
    <dbReference type="eggNOG" id="KOG0285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXH6"/>
    <dbReference type="OMA" id="FAMCFDQ"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VXH6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="503" mass="54373" checksum="A9548E85125A456F" modified="2015-04-29" version="1">MEVEPTTTESFADNNDSIGNDEPVPQHSLQTLVFRSVKRTHDMFLSDYGAPVEIPVEHPSVRLCLDAKFQDEYSHLSLQAAQKGSAGPLGPAAAGAAAAVAQNGSAPASMLMLTNGAAGNVATVVTGSTDASSRAMVVSQGRSNPVLQSAAAAAAAAAALPQTRALALQASAPKMPKPDWHPPWKLMRVISGHTGLVYCIAMDPTNQWFVTGSADRMIKVWDLASGTLRLSLTGHISSVRSLAVSARHPYLFSCAEDKSVKCWDLESNKVIRHYHGHNAAVYTMDLHPTLDVLVTGSRDATARVWDMRTKACVHVLTGHKSQIDVVKTQAADPQVITGGADHTIRLWDLAAGKTRVVLTNHKKSVRTLALHPTEFSFVSGGADNIKQWRFPDGMFLQNMEGHNTIINTVAVNHDNVLMSGGGDGTIFAWDYKTGYNFQQLSSPVQSGSLDSEAGMYASTFDMSGARYLTCDFDKTIKVYKEDETATPESHPLNWKPGMLKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXK1</accession>
    <name>A0A0D2VXK1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344346.2">
        <property type="nucleotide sequence ID" value="XM_004344296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXK1"/>
    <dbReference type="InParanoid" id="A0A0D2VXK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253987" evidence="2">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="23658" checksum="A77205FFE3972C16" modified="2015-04-29" version="1">MRKSPCRIAFILLLIALLGAPALGQSTRSSNNDDQANTPAPPAQTTPAPQPPAQSSTTPNSPEDGEEAPEPVSTPPARPSSAAQPAPTTAAPPPQPASSHTPVPVSSNTPIPAPVSSNTPIPAPVSSSTPIPAQSSAPSSSSSSSSSSSSSSAAQSSSAPATSSKSSVNLYPSFKPPGPIGPGPTTIVYPTYYPNPGYNGDGSNNDYNQDKNTNSASGLQATLLSLVLPLALMLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZH8</accession>
    <name>A0A0D2VZH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343573.1">
        <property type="nucleotide sequence ID" value="XM_004343523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZH8"/>
    <dbReference type="STRING" id="595528.A0A0D2VZH8"/>
    <dbReference type="InParanoid" id="A0A0D2VZH8"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="490" mass="52438" checksum="3EE8243BD79586EB" modified="2015-04-29" version="1">MATAAGAAGAAGAAALIAASRRCIATSARALLPRRTAAQPRRATAALSSNDDSNNDAGGHQQSAHRIDAAVEQDRVASDPILAHLAANTIVSRPSPTAPTTTKTTTTTTTTAAAAGLGRTRGAAADARRRSPVLAPAAAAIQPLQPAAPLVHRELAASEDDDAQVTIEDSPLGAARAARSANQQPPPQPFRARAQPAPEQVAEPVETAEERIQRLQHMFEDKSLVVEEAARILRRGAVTDLVAIAGRISENAEEDEAQSVDVQFPPELAADLAARHRVTLATLAAGSNATSSRKSSPKDLDAEPPKRFTLFDTMLIATAKSSRHMEALARDLGAAFKVPGTTQQPYFKQEGSDFWMTVELGQVHVHMLQAPARAYYKIEDLHVFRHLDPETIRFMRERQAMGELVKKPAGGKPVNPDKVQKGTIRRERKLRSEKDQAQRQEEKRVRVQAALAQQQARKSAPKSPRQPAASPSAGETSNTSQRSGGKSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0M9</accession>
    <name>A0A0D2W0M9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342966.1">
        <property type="nucleotide sequence ID" value="XM_004342916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0M9"/>
    <dbReference type="STRING" id="595528.A0A0D2W0M9"/>
    <dbReference type="eggNOG" id="KOG3938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0M9"/>
    <dbReference type="OrthoDB" id="9442170at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020984">
        <property type="entry name" value="Speedy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052316">
        <property type="entry name" value="Speedy-Ringo_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545">
        <property type="entry name" value="SEEDY PROTEIN A/C FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545:SF5">
        <property type="entry name" value="SPEEDY PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11357">
        <property type="entry name" value="Spy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="644" mass="70249" checksum="DE0514EF249DBE89" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1Q1</accession>
    <name>A0A0D2W1Q1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_008252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1Q1"/>
    <dbReference type="STRING" id="595528.A0A0D2W1Q1"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1Q1"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1Q1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21201">
        <property type="entry name" value="CH_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="13">
        <location>
            <begin position="229"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="436"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="555"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="707"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="804"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="905"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE98262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1207" mass="129684" checksum="ED888C224900A756" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1S5</accession>
    <name>A0A0D2W1S5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346379">
        <property type="protein sequence ID" value="KJE98292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1S5"/>
    <dbReference type="InParanoid" id="A0A0D2W1S5"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1S5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114119" checksum="05025242FAE4F02F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGB2</accession>
    <name>A0A0D2WGB2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364960.2">
        <property type="nucleotide sequence ID" value="XM_004364903.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGB2"/>
    <dbReference type="InParanoid" id="A0A0D2WGB2"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGB2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028156">
        <property type="entry name" value="RIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028159">
        <property type="entry name" value="RPA_interact_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742:SF1">
        <property type="entry name" value="RPA-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742">
        <property type="entry name" value="RPA-INTERACTING PROTEIN RPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14768">
        <property type="entry name" value="RPA_interact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RPA-interacting protein C-terminal" evidence="6">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="35036" checksum="BC656CDBD439D6F9" modified="2015-04-29" version="1">MSAPKRANPGSNIAKWQNHRSGRPVDSMEAFRQSFTERCKQNWQAARSRFFNQRRGLGDDSSAENERTSEGAPTEQGDGLDAYLYSFLQSELASYRAGATAAPGTTTVEASSGLASATAMQLGTADECFDNYEAALAQSTRSAAENDEDRDYTDDEREEIMQEFMLQVLQELIEQERERNLALYDDYEKALQRDEAPRHSADIDNEFDVEDDAESAAYFEEALRQADSTVCPLCWQGQLSQRMQAIMCNHCGFAMDTQFDSITLPQLQATIHERLQAHSAACPQRPFFSYQANVAGSLLHLRCNYCDCFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGQ6</accession>
    <name>A0A0D2WGQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365111.1">
        <property type="nucleotide sequence ID" value="XM_004365054.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGQ6"/>
    <dbReference type="FunCoup" id="A0A0D2WGQ6">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGQ6"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGQ6"/>
    <dbReference type="OMA" id="RSPQFMQ"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="248"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="371" mass="39775" checksum="34803E20C1DF192A" modified="2015-04-29" version="1">MSLFQQQSTQRQSNNRLVEFRAGRLTQSGTTVTADPRKGLLYMHVEPTDQLLHFVWKDRGTNAIVDDWIIFPEDAEWKRVPQCTTGRVYLLKFKSSDKRWFFWMQEPKIDKDDELAERINKILTSSDPSSLAQPQPSPAVSRQSALMQSMGLTPAQITQMLGAQAARPQRSNRQRMEPAVSGSPPTAPPATAAAAAAAAAIPDTPVPETPASAPSGAAAGAPAVTQTPTASAAQQLEFLQQFASSLAAPRQREQIGLSHIITPDALNLLLSNDQVVEQLLPFLPETLPHTAAELRTTVRSPQFSQAVQAFSAALGAGNLNAVMQQFGVDPSLAGSAQGVEAFLTALQQSQNQSSGSSDASNTGSSNMDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH99</accession>
    <name>A0A0D2WH99_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH99"/>
    <dbReference type="STRING" id="595528.A0A0D2WH99"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH99"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="49782" checksum="F06BF116ACDBFC14" modified="2015-04-29" version="1">MLTGNLPKLLAFSGSAPSAIGVAAARSLCSGGVLVAHSTPGPGMHSAARDAPRAVAAAEEGVANPTRSGSDDAHPGYVPEPTEPGDRRHRLVIVGSGWGGFSLLKYADAKRVHVSMVSARPFFLFTPLLASTCVGTLEFRSIQEPVRNMRFPNEGDFHQAIVTGVDTSKQLLLCQSALDASYKYSVHYDTLVLGVGMRPNTFNIEGVTKYGHFLKELADARAIRVHLLRNLELACEPGVSAEERQRLLTVVIAGGGATGVEFGAELHDFLVQDLPKLYPHLQDHIRIVLVEPNDILGAFDSRLRTFAERKIRQRRDMTIVRKFIVDVTEKNVHFKDGTTHPFGVLVWVTGLAPSPLAVSLSQFPKNKQHQFVVDQQLRVTGIPNVYALGDCAAMTPALPCTAQVAERQGRYLASVLSNLGSDSAAVASAPPFVFKSMGMMAYVGDHDAISDLPVTKLSGKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHB3</accession>
    <name>A0A0D2WHB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHB3"/>
    <dbReference type="STRING" id="595528.A0A0D2WHB3"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHB3"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="558"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="943" mass="99412" checksum="CD118A6544F97516" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHP7</accession>
    <name>A0A0D2WHP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHP7"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHP7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="511" mass="55083" checksum="1048BDA49582E8D1" modified="2015-04-29" version="1">MLAVAAPRVWLVAVHLVINPNQNTAQKLLCKPNLKPSLGQALNVQSWMSTRSLRPRRLSSRRRREIARAIDEEQMRHADQASAQCVICLSSFTERGRLPTCPHLFCAPCIQAWADVNNACPMCKLVFRVIIVEEIATKLVLRKIRVESREQPQWYADQMPIPDETDEHEEDGSGHAAHSPSFLEHEHNVEDKNEDEDEDEDEGEGEGEDNDNHKLQHRGRRTIARATRLPSMSDSSAPCSSSSEQTSSATGAAVFDFDVDFDDDARHPPPKRSRVGHAQDRAPLRSAPFMFQPLAHAFASGMPRPRKAPPLSDIEDSDGDDSNPNPVGSSSAAPAPLAQSSSSPPPQLAASGTDAADTSFVAIESPAHPALARCHPPHARANRAPLANVGNLLHIAQQPSKQANNSACQPPGSPVFIDLSSTPSRASQPIVSQSPSKRTAMPRSFSLSPIKGNVRTLVPSTPSPPGSPEASCLPLTPAAVVLVPDTPPSRKKRASGAAPPILIHSQSFGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIJ1</accession>
    <name>A0A0D2WIJ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365317.1">
        <property type="nucleotide sequence ID" value="XM_004365260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIJ1"/>
    <dbReference type="InParanoid" id="A0A0D2WIJ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="707"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="981" mass="106568" checksum="1A544C26BF6BD5B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIK6</accession>
    <name>A0A0D2WIK6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365344.2">
        <property type="nucleotide sequence ID" value="XM_004365287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIK6"/>
    <dbReference type="FunCoup" id="A0A0D2WIK6">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIK6"/>
    <dbReference type="ESTHER" id="capo3-e9bvx2">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIK6"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIK6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="14">
        <location>
            <begin position="147"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="13">
        <location>
            <begin position="624"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="829" mass="89135" checksum="8C90631FAC9E700D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIR1</accession>
    <name>A0A0D2WIR1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349700.2">
        <property type="nucleotide sequence ID" value="XM_004349650.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIR1"/>
    <dbReference type="STRING" id="595528.A0A0D2WIR1"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIR1"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIR1"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="310" mass="34046" checksum="4FF36301EA767A68" modified="2015-04-29" version="1">MSASILTQSHPAPVHLVRWVASIRDQLKPPVGNKLLNGDGCEFKVMVVAGPNTRTDYHLEDGEEWFYMVEGDMCLRVVDGGVFRDVVIREGESFMLPGNIPHSPQRLANTIGLVIERERDQTEIDHLRWYCPQCREIVHEGTFHCVDLGSQLKPVIEGYYASTESRTCSKCGTLDLHPSQRTPPAADPAGAAKKPGHNSINPDTHPNPFNLRQAIEAKGIAPGSSAFLYGPESQFHLKASRGPSTSVEFKAAANETWFYQLSGSCTVNVQVADKTESVQVDEGQCYLLPRGISHAVQRSADSLGLVLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ39</accession>
    <name>A0A0D2WJ39_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365617.1">
        <property type="nucleotide sequence ID" value="XM_004365560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ39"/>
    <dbReference type="STRING" id="595528.A0A0D2WJ39"/>
    <dbReference type="eggNOG" id="ENOG502RZMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ39"/>
    <dbReference type="OMA" id="KDFYPGW"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ39"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04697">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="199" mass="22188" checksum="2591ED6B351AAD51" modified="2015-04-29" version="1">MSTAYQRVADPSQGLSKSEPVAIVDEQDNVVDVVPRWRVRKDNLRHRATFIFVRHREAGKPVPASWQDELFVVQKRALIKDYCPGYLDACTGGVMQDGEEYEPSARRELEEELGISAASLTPLFHFLHEDSVTKVWGGAFLCDYTGRLADLVLQPEEVLSVETLTLGDMVARSSAGEPFTPDSMSAVKRYIAQLEAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJS5</accession>
    <name>A0A0D2WJS5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJS5"/>
    <dbReference type="STRING" id="595528.A0A0D2WJS5"/>
    <dbReference type="InParanoid" id="A0A0D2WJS5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13270">
        <property type="entry name" value="PROTEIN C20ORF116-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13270:SF14">
        <property type="entry name" value="SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1129" mass="118667" checksum="E1ECC45D95D5B12E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKG4</accession>
    <name>A0A0D2WKG4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364871.1">
        <property type="nucleotide sequence ID" value="XM_004364814.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKG4"/>
    <dbReference type="eggNOG" id="ENOG502RK9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKG4"/>
    <dbReference type="OrthoDB" id="74158at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF76">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="80007" checksum="CD5BF958CBBE4700" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMG4</accession>
    <name>A0A0D2WMG4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_003052</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363891.1">
        <property type="nucleotide sequence ID" value="XM_004363834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMG4"/>
    <dbReference type="FunCoup" id="A0A0D2WMG4">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMG4"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMG4"/>
    <dbReference type="OMA" id="ASQNICI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMG4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04113">
        <property type="entry name" value="Rab4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000280">
        <property type="entry name" value="Putative ras-related protein Rab-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041819">
        <property type="entry name" value="Rab4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="221" mass="24116" checksum="FA569D0075157C5C" modified="2015-04-29" version="1">MSEGYDYLFKFLVIGNAGVGKSCVLHSFLEGKFKQESSHTIGVEFGSKIAKLGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITNRESYNALANWLTDARTLASPDIVIILVGNKKDLEDDREVTFLEASRFAQENDILFLETSALTGENVDEVFMKCGRNILSKIESGELDPEKMGSGIQYGDNKNVKAPLGNAERTVDPAVTGGASKPPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMV1</accession>
    <name>A0A0D2WMV1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270301.1">
        <property type="nucleotide sequence ID" value="XM_011271999.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMV1"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMV1"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1449"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1482"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1552"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1617"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="674"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="785"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="878"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1408"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1747" mass="184283" checksum="2B83E6B364E1D99C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP01</accession>
    <name>A0A0D2WP01_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363597.2">
        <property type="nucleotide sequence ID" value="XM_004363540.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP01"/>
    <dbReference type="InParanoid" id="A0A0D2WP01"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26342" checksum="EFF91DA139FDF67C" modified="2015-04-29" version="1">MGNILYGDLYDRVRSASGTYLLQSQFIGPKRAQDAANGLKENCTLLMLNFYRSAVGDVGAQAIADALKVNSTLTWLNLSENNIGDLGAQALAEALKVNTALTTLHLGRNNIGPQGAQALADALKLNKTLTALHLDSNRIETAGAQAIADALKVNQSLTEIDLQSNRIGAGAGQALAEVLKVNQALATINLNINKIGEAGAEAIADALKVNRTVTTLHLWSNEITQPGTRAFAAALKTKLECNEADWVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP98</accession>
    <name>A0A0D2WP98_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363680.1">
        <property type="nucleotide sequence ID" value="XM_004363623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP98"/>
    <dbReference type="STRING" id="595528.A0A0D2WP98"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP98"/>
    <dbReference type="OMA" id="NRCATRM"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30432" checksum="25426106F61C36E4" modified="2015-04-29" version="1">MQNSALAGKSALVIGGTNGIGRGMAEWLAQQGASVTVAGPTSAGSSAPTYAFSPINAQSVADVGKFCAEYLRTHDRLDYLVVTAGIATMQGRTETDEGIDQKLAIHYYGRVAAIQGLLPLLESTAKLPNADVRVLSVLSAGVHSAYANYRTDPEVRTYSLQRAANAAGFYNDLALDALSREHPTVTFAHAAPGLVSTSLGAELNPFLRGVVRAMQLFAKSPERCARLIGAALIAPEFKGGFHLVNPNGKPAKRTPQHDEARDFVWQNTKEVLARASATGAAANAAKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPV6</accession>
    <name>A0A0D2WPV6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPV6"/>
    <dbReference type="STRING" id="595528.A0A0D2WPV6"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPV6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="726"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1017" mass="103682" checksum="7A5389F86C4DBE87" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQQ6</accession>
    <name>A0A0D2WQQ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQQ6"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQQ6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="44845" checksum="129A8C81D2ACDC35" modified="2015-04-29" version="1">MEWDSLIHRRIGDAGAQVIAEELKRNATLARLGLIESQIGDAGARAIAEALTVNTTLITLSLEKNPIGDAGTKAIAEALKVNLTLATLLLGENQIGDAGVQAIAETLKVSTTLTRLQLQKNQIGDAGAQAIAAALRVNTSLTELNLGLNQIGDVGAQAIAEALKVNKTLAWLDLGQNLIGDAGAKAIAEGLRENTTVTRLHLDRNRIGYDGAQAIDDARNATKALTYCSIDNQINPLAFSLLPRLATAKDLQTVFHWLVSGPELQDQPAALPALPVELAERIMDEACYWQGVQHTKRSHFHDGTTNGALTVTVPQGIAGNSVRVKAIQVLRDEKHWLDPPYSTNGKTFDLVVRDKGGVVRYECAANATFVDSNLNLVTIRPASHPFIRQLRKGWQVQVLPSKSFGISLIESLYLGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR07</accession>
    <name>A0A0D2WR07_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348143.1">
        <property type="nucleotide sequence ID" value="XM_004348093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR07"/>
    <dbReference type="InParanoid" id="A0A0D2WR07"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="17442" checksum="1853DDC5A0D4AFE9" modified="2015-04-29" version="1">MDHTTNRSAAPTQSFEKQANVAVAMMDDGLHGAPKTAPRTAPETAPMALLFCGLAFVFAIYVVYCMRYVPSTMDALFIIAQPLSFLLVDATWNWTYGKPRQVSCAALSAAGLAYLAITYLSAPSEPWIWCVLVASQIAGIAVSNCSIAVQEEQDDPYLPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR12</accession>
    <name>A0A0D2WR12_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348151.1">
        <property type="nucleotide sequence ID" value="XM_004348101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR12"/>
    <dbReference type="eggNOG" id="KOG4526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR12"/>
    <dbReference type="OMA" id="ATNTWIP"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="240" mass="24860" checksum="39BFD69DA9F35236" modified="2015-04-29" version="1">MASLCLLRARVALCGQSYTCAPSISGRVGVAAVTGFGLQPASSSTSIARSLSSSATGWLPAAAAVARPGSSWMNARVTLPAMASKPLAQSHSRGLSLAARSLAAEKPASATSSTSTSGPDAATSAKPPKEESRFRRFVREYGRVGLVTLIAIDLVTYAAVYAALSFGVDIPAVFDYLGIEHAWFNPNAGQFVVAYAVYKVTAPLRWGFALGVTPAIVSKLRSMGWIETPPPSPPSPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRL4</accession>
    <name>A0A0D2WRL4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347382.1">
        <property type="nucleotide sequence ID" value="XM_004347332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRL4"/>
    <dbReference type="FunCoup" id="A0A0D2WRL4">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WRL4"/>
    <dbReference type="eggNOG" id="KOG2919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRL4"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="539" mass="57670" checksum="DD55DA90F735CE7B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRR7</accession>
    <name>A0A0D2WRR7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_005278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRR7"/>
    <dbReference type="STRING" id="595528.A0A0D2WRR7"/>
    <dbReference type="eggNOG" id="KOG4278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRR7"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="269"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="340"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="466"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="528"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="590"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="783"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1073" mass="115818" checksum="95030354EE97714C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSA4</accession>
    <name>A0A0D2WSA4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347707.1">
        <property type="nucleotide sequence ID" value="XM_004347657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSA4"/>
    <dbReference type="InParanoid" id="A0A0D2WSA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="126" mass="13670" checksum="2FC613838414C7D2" modified="2015-04-29" version="1">MAAFEHPPGAICDFESELPHRSYLEKLKSRSGCALDHKETGEVNAASVSDKDDLNDNDDDDDDNSSVSSDDCKSATAFVGDAPRRPGPIRSRLPDDSSLKTFLALQDCMSFSLTTLLCPNMSLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSE1</accession>
    <name>A0A0D2WSE1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSE1"/>
    <dbReference type="STRING" id="595528.A0A0D2WSE1"/>
    <dbReference type="eggNOG" id="KOG4069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSE1"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="68"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="214" mass="22721" checksum="F7C610BB12600C85" modified="2015-04-29" version="1">MSASLVLEPEAVSLQPQPDTRPFSPAGPAGPAGSFGASASAAAGAAASTSTGGGAAAGGDEAFRFQGVEVERDYSHGMACQFQSQFPVELTGLISQEAFTKTIDHINKLFEHSEDVDAKSALFSFVSCLCGFLCFPMLESRYDRTLKALDKYIQDQNQQVYHPLGLHIIPPIRSGLRVALPVAHRVSAFVAIMFCMKTASNSAVLPTEHITLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSP8</accession>
    <name>A0A0D2WSP8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSP8"/>
    <dbReference type="InParanoid" id="A0A0D2WSP8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52201" checksum="6C0EF2DC83C90034" modified="2015-04-29" version="1">MVRGKKRRLTLWEYIRRENTARQVREQRAREVVVALAVAAAAAAAAAAAAAASASDAADASSAASSSAASELSPAAVEAIVQNMTKTQRGLFNKVWKTRERLFLNKQQIDDAGAEAVAEALKVSTLLILELETNQIGEGGARAIAEALKVNTPLTTLMLHQNQIGYAGALAIAEALEVNDTLIYLGLNANQIGAAGAQAIAEALKVNRGLIQLFLHENQIGDAGAQAIAEALKVNKTLWRLNLDKNRIGDAGAQAIAETLKVNKMLIELSLRWNCIGNRGSQALDEARKVNGFRELFSELQINPLVFSWLPRVATAEDLQTVFCLLTSGLELENQSASLPALPAEIADIIMEDAHYWQGVQHTRGNEFFEDKNHPPLSVTVPRDVTGSPIRMKAIQVIREMQFPDTTLGVCFELSVRDGRGVARYQCAVKPTRIDSSIGLVLLRPGSHPIFEQLREGWEVLLQPSVYGMQVGIESLTLAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU82</accession>
    <name>A0A0D2WU82_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_006515</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU82"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU82"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="173"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="462"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="1384"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="1495"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="1773"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="977"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1229"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1572"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1145"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1257"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1304"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1586"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1613"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1652"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1666"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1690"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1719"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE96150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1840" mass="199331" checksum="A70373639C0EAF4C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUA8</accession>
    <name>A0A0D2WUA8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345512.2">
        <property type="nucleotide sequence ID" value="XM_004345462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUA8"/>
    <dbReference type="STRING" id="595528.A0A0D2WUA8"/>
    <dbReference type="InParanoid" id="A0A0D2WUA8"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="6">
        <location>
            <begin position="299"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="568" mass="61727" checksum="1E0FDA3A34F76F1A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUC3</accession>
    <name>A0A0D2WUC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUC3"/>
    <dbReference type="STRING" id="595528.A0A0D2WUC3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUC3"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUC3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF395">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254664" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="69072" checksum="6F2B5B0B238AD695" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV57</accession>
    <name>A0A0D2WV57_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">15-hydroxyprostaglandin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV57"/>
    <dbReference type="STRING" id="595528.A0A0D2WV57"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV57"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV57"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="229" mass="24388" checksum="BD1357C646BFC141" modified="2015-04-29" version="1">MQVALVDLDTNTGEKLSAELNAKYGSDRTAFIKCNVTKEAELEHAFSHTFKLFGRLDIVANNAGIAREPDWQLVIDINLTAVVAGSRLAITYMSAPHGNGGVIINTASMGGLIPMPYAPVYAATKAAVIQYSRSLGQAHENIRVNAICPSFTDTALVAEGKTMLPTVFGEVVAATGPLLSPELIATSMIAIVEDDSKNAAVMRVTNARGVDYQSYDGFLNKSTPLTPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVF3</accession>
    <name>A0A0D2WVF3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sec61a1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVF3"/>
    <dbReference type="FunCoup" id="A0A0D2WVF3">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVF3"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVF3"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVF3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="501" mass="54957" checksum="C56718C15A782E43" modified="2015-04-29" version="1">MYSTSISSKDQSGFCFFTVSSFCQVMGFLHYLKPFISLIPEIEAPVKKVPFKERAIYTVITLVIFLVCCQVPLYGIMSSDSADPFFWMRAILASNRGTLMELGISPIVTSGMIMQLLAGAKLLEVDQSNADERALFSGAQRLFGLIITVGQAIIYVATGLYGPVGELGFFVCFMLVLQLLIAGLIVMLLDELLQKGYGLGSGISLFIATNVCESIIWRSFSPTTVNTGRGTEFEGAVIGFFHLLATRSDKFKALREAFFRQNLPNLTNLFATVAVFLIVIYFQGFRVDVPVVSRNAPGVVQTYSIKLFYTSNMPIILQSALVQNLFIISQLLWFKLSHTGLGWIIGLLGSWENVAYQGSNRSYPVGGLCYYLSPPNGLTGVVADPLHGMIYIAFILGTCALFSLLWIDLSGASSQDVARQLREQQMFVKGHKDTQESTARQLNRYIPTAAAFGGLCIGALSITADFFGAIGSGTGILMAVTTIYQYYEIMAKEQISMGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVJ7</accession>
    <name>A0A0D2WVJ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345342.2">
        <property type="nucleotide sequence ID" value="XM_004345292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVJ7"/>
    <dbReference type="InParanoid" id="A0A0D2WVJ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254696" evidence="1">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="167" mass="17169" checksum="86DA6C00393EC89E" modified="2015-04-29" version="1">MVMMTTMMMMGRRVVAALPALASSAPSMSAATATATAGPATVLAATAPIYHQQPSRGVRRRNAARMYRGIVILSDGSTVEERFSTPGRVVVLTDDRLNSPPFVTTKSRTQDEQIAQFYENKLGVGSAAAILANRSMSSKNAAADAAAAAAAAGVDVAAAAATPAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX36</accession>
    <name>A0A0D2WX36_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX36"/>
    <dbReference type="STRING" id="595528.A0A0D2WX36"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX36"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX36"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254863" description="LRRNT domain-containing protein" evidence="14">
        <location>
            <begin position="27"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="914" mass="96648" checksum="D1A199E4AE4DE00A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX47</accession>
    <name>A0A0D2WX47_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342850.1">
        <property type="nucleotide sequence ID" value="XM_004342801.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX47"/>
    <dbReference type="STRING" id="595528.A0A0D2WX47"/>
    <dbReference type="InParanoid" id="A0A0D2WX47"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX47"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22934">
        <property type="entry name" value="HFD_TADA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="33826" checksum="4B311FDFD6204529" modified="2015-04-29" version="1">MSAPEGEAAASAGPPQQQQQQQQQQQQQRASRPPSAVSAARSKLNAALGANGPVYYDMLKRYMLAEATKSELDATARNLLGDDHFGLHTAFLRSSIQNAAAKSAVPRKKRPLSADSSGAGTPVVDTPQESNQSTTVDMTAVQEEPTPQDERAFASSTDEWQPVQHDARPANTRAVTLCSQLRRLPTVAEMRARLFVTAFDYELHDVTDEAAKLLVQALEYHMMNVIGKTIWWKKRGRRKASVVRRELAAQIPQPHAELALPLIDIPDPAALTDPLGPEDLLLALSMSPSLLGDDRLSKERILSRLRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY50</accession>
    <name>A0A0D2WY50_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346384">
        <property type="protein sequence ID" value="KJE98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363272.2">
        <property type="nucleotide sequence ID" value="XM_004363215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY50"/>
    <dbReference type="InParanoid" id="A0A0D2WY50"/>
    <dbReference type="OrthoDB" id="5945766at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY50"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="498" mass="56197" checksum="ECD701314AFD7CE7" modified="2015-04-29" version="1">MSKLELLFQRRWLLLFICLTCILLSLFVLLPNGGEHVPNSFVTDAQFRLGRHALSHGDPAAGSEFAELLHAQTTTSDDDDRVEQLSSETRVLSIKNAVGRQLTATNMTTEKDTSSDSTLSSSSSSSSSSSQLIACDDYFARNNVLLVLQFNQALPQYYDHEKYFRGAFRHVVLSIPEPSSDPQSNHFVCPDGYAGRYAYYCLSSIMLRYPEYRGYLYVHFDVFLKFWQLHDMPLNTIWTSHFYKYQNDPDWVHWGRPWGMRALNKMYKRALSDCGSRSHRFEACQLIDEWATRGGSTKFRVGDFADVAYIPSEHVRNFVWFSSYAHLTKVFAEIAIPLFASLTQESFKRLHPELPNAAAATHTVLEGVDNLTPNTGELATWFYAVCTSDSVHFCHRTDFRVPSLAAFYDLSMSTCSAPRVPSTLDLDLDYLSDLRAQQSIGNRALRGAAYVLLLVCSLILSAGLVWLVARAITVARNKREHDDRVKPCAASFGNCSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYF2</accession>
    <name>A0A0D2WYF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342616.1">
        <property type="nucleotide sequence ID" value="XM_004342567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYF2"/>
    <dbReference type="STRING" id="595528.A0A0D2WYF2"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYF2"/>
    <dbReference type="OMA" id="NCKLDVT"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="355" mass="39722" checksum="11F8F531259582F1" modified="2015-04-29" version="1">MNQIFIRTHKGEYVGGETIYGTVYLNLAIPLPAKSLELRVKGVERTKWNYVHYESVSDGQGGTTQRREIREHAGKKEFFKVKIVMYEYPTIFTPGYFAYPFQFTLPANLPGVFMKHKKSREDTRMKAEIFYKIKATLDIPGTKHDLKITQPLVIHERLDLAIAPQHYTKNGTVRLLCCIPRGDVNVEAWMDKNAYMAGETAQIHVRVQNGSKSNIDNFAVKLMRVITITNGHGASKVITDTVAQQQYPGCLAGESKESDIPLPLVSKKGARGAIKPATTAGLVKCVYHVDIEMQIPWAPDVEIHAPVKIYAPANFAWAQWQPPQWAAQATIQPVMGDLSVPQAVLQTQFTGLPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ12</accession>
    <name>A0A0D2WZ12_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346421">
        <property type="protein sequence ID" value="KJE98418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ12"/>
    <dbReference type="InParanoid" id="A0A0D2WZ12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="159" mass="17251" checksum="FD97487FB3EE91A3" modified="2015-04-29" version="1">MATSATSSPVPGAALSLSHFSQFTRLLQNSRKKQPCGSQPAAIASAERADEKDSFEEDEPAHHVQLSLSQSTPSSLAAPKPVMKMFQLPPPPHHIPSMDRLVESRSEADETLARSESRSSAIVRDDSTHSSGHSRPQQQQQQQQIGAARTDSAADWRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D9</accession>
    <name>A0A0D2X0D9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365334.2">
        <property type="nucleotide sequence ID" value="XM_004365277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0D9"/>
    <dbReference type="InParanoid" id="A0A0D2X0D9"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0D9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="823" mass="91608" checksum="C23EE28F296DED1C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0E8</accession>
    <name>A0A0D2X0E8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365373.1">
        <property type="nucleotide sequence ID" value="XM_004365316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0E8"/>
    <dbReference type="InParanoid" id="A0A0D2X0E8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="366" mass="39133" checksum="667B71CE6710462A" modified="2015-04-29" version="1">MQTAKSAKPTISPRMERIQAQDVHVRARIAACAARAQAVLDLLAKYELAEAARADAQPAEASRSGPSASGAEQAVSDAPSETVHAEATALTPETMSAGFSEPRGQPKKKGAKSQSRASPTNVQAGRQQAHASKPTPRPDSAAVAHARETLVHAWLVDHLLQQSGSVLAHFPYVYEHEWDASGSPDGGRQVIPREQRRERLGSGDLVLHAASGSEFAVVEVKLIEFPPRRNQIEKTEGNPKEPCTSAPPGHEDLSPARQAAETETLPAIAPTSADNATETSKCDASDAGGDSSSKDSRLLSRQQPNANTSRQKAAKLREQALRYGEWWMRKHPQAITRVFTVTGASEDCISELGAYAKGAWLPVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K1</accession>
    <name>A0A0D2X0K1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365590.1">
        <property type="nucleotide sequence ID" value="XM_004365533.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0K1"/>
    <dbReference type="eggNOG" id="KOG0685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0K1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0K1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF418">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="460"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="949" mass="101271" checksum="6E7E87C1BBA2BF01" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0T5</accession>
    <name>A0A0D2X0T5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VMA21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0T5"/>
    <dbReference type="InParanoid" id="A0A0D2X0T5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="133" mass="13800" checksum="1D242796BACD4C9C" modified="2015-04-29" version="1">MSTQPSTSAAASPVPVTAGIVNAFHLVQFVPLERVNAAAADLVVVCRPRVEPGVLRTLLIFTFAMIVAPIGMYYFAAAIAEQAEASMPHIVGAIAAVVVVQIVMAAFVVVALREDKNTAATSSANPADKPKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X299</accession>
    <name>A0A0D2X299_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X299"/>
    <dbReference type="InParanoid" id="A0A0D2X299"/>
    <dbReference type="PhylomeDB" id="A0A0D2X299"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="5">
        <location>
            <begin position="1214"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="822"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1532"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1573"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1600"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1918" mass="208879" checksum="6BAE91C699E85AD6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2E4</accession>
    <name>A0A0D2X2E4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENND10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364230.1">
        <property type="nucleotide sequence ID" value="XM_004364173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2E4"/>
    <dbReference type="STRING" id="595528.A0A0D2X2E4"/>
    <dbReference type="eggNOG" id="ENOG502QVHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2E4"/>
    <dbReference type="OMA" id="HKDIAMF"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2E4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042431">
        <property type="entry name" value="FAM45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544:SF1">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544">
        <property type="entry name" value="PROTEIN FAM45A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="361" mass="39801" checksum="99550804BB619217" modified="2015-04-29" version="1">MPVEKLQAVALLEKDTNGDTMWTWVYPALDATWRELLQRKSGLEAASATVELPAFVYGRFADTYFYIVNLVTSPGAPEGETPSPAAPDSSDLPVLPRVTAFSLVLLAKEFHPEKYEAIARLCAAEYTTSKGNTVAVVQAYLNIFTLGRHGDFAEEQYDIRKSYLGASLKNVIQTFGLETILLYAALLLKKRVVVYADTLDTLYDFVRPLPLLVWHRQNWDSLRPYVSVNDSELADLAASGNFVAGFTDENIENHSDLYDVFVNVNTKSVSLAPHAQESLALGKVHKELATFLTQVAADEARSESAVVKAIAVRTGELLTKIRSLTDESGRVTYDSLKALELPPSSINFLWNVALSEAIAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2F0</accession>
    <name>A0A0D2X2F0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364260.1">
        <property type="nucleotide sequence ID" value="XM_004364203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2F0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2F0"/>
    <dbReference type="InParanoid" id="A0A0D2X2F0"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2F0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="499" mass="55704" checksum="E8EE61A6C44EF3C0" modified="2015-04-29" version="1">MFGTQKIKQSIAVPRRLTIALLALGFAAALLFLALSGAGTISPKPPSDETLTVQYQCQQHNWWAKRTSLRVPPPEQQPQPTPQTLKDALGKSITPIKPAWVRVDVRGTDTHVPPAPVVNASVARAPLGAFVPRDALLQTTGLQCLVLQDHQSLAEQFHGFWDGPMGQSLPPLYLSAISTVFRQHPDSTFLVHSNTLPLDQFDSLRAMGFNIAVVRFDAERALTYGKLPGLRWLREDRVRHAEHRNIRTHTSDLMRTIFMYQCGGIYLDLDSVLLRPLHFLNRAITMEPMRPDHLRVQYIKMSAPTSMLSCNEGVVVRPEPVGQDGSMTLSPYILHGDFALVPGVLAFGPRDNFIYMMMQVFDEAYDPSCFSCVGPMAANKAYMASTPAEKIRLQLYPADVMFGPNWSGVLDKNEEFWVTTTEERARILINDAAARGFTQHLYGSGQGAPKFDRNSYIHRLLLTFQLLPLPDVWSPEQPQQQQPPAVLSSEVVDPNELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T3</accession>
    <name>A0A0D2X2T3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_003947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363675.1">
        <property type="nucleotide sequence ID" value="XM_004363618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2T3"/>
    <dbReference type="FunCoup" id="A0A0D2X2T3">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2T3"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T3"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="171"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="385" mass="41388" checksum="81EB87634B86C481" modified="2015-04-29" version="1">MLLHRPTAASSASPPPPPPLQEQQCRLVLAAASPRWDALCTTGADVQALIDIAESVQPASASASSSVPVAGPGAAVGGCGGAFQAAFSRLVAALGQGSQGTSIIRNTAHDDDSHDSQSNGDVGSAVRRSDESTATTLTLATAEQVVHLALCVRQATTAIEQALQIYKTDTIMLSFNGGKDCMVVLHLLNAVLRTRCGRHNAENSRHLPIPAIYLSFPDQFHEVESFVREAAQDYSMDLFTIDGSIKAGLTELSKQRPQVRAIFAGTRRTDPFSASLETCTPTDPDWPQFMRINPILDWSYADVWLFLRAFRVPYCHLYDLGYTSLGGRSTTSPNPALLRAGTQSPPRFSPAYLLQDGSKERDGRRPSLQPQSPQQSSRPSAQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2U6</accession>
    <name>A0A0D2X2U6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAMK/CAMKL/AMPK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2U6"/>
    <dbReference type="STRING" id="595528.A0A0D2X2U6"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2U6"/>
    <dbReference type="OMA" id="IMPERES"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2U6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="264"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="517"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="751" mass="82690" checksum="51DF4963D3C2C9EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2V5</accession>
    <name>A0A0D2X2V5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004038</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347863.2">
        <property type="nucleotide sequence ID" value="XM_004347813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2V5"/>
    <dbReference type="STRING" id="595528.A0A0D2X2V5"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2V5"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="977" mass="106425" checksum="10E1394B8E78C587" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3B3</accession>
    <name>A0A0D2X3B3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3B3"/>
    <dbReference type="FunCoup" id="A0A0D2X3B3">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3B3"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3B3"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3B3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="48"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="482" mass="51638" checksum="E75DC686D8FCF440" modified="2015-04-29" version="1">MADQASTSAASSSAAPAPAKGSHLRTQTLEGLDVATLSPLSPDVLSRQATVNIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNPACPRPGNYRSASSNKEDDLPCERLGCSGRFRILRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHIIILQNKIDLVREAQALEQHQEILKFVDGTVAQGAPIIPISAQLKYNIDCVCEYIANKIPIPVRDFTAAPRLIVIRSFDVNKPGAEVDDLKGGVAGGSILVGVLKAGQEIEVRPGIVAKNDEGRLKCTPIFSRVVSLFAEQNELQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGSVGALPEIYTELEISYFLLRRLLGVRTEGDKKQAKVQKLTKGEVLMVNIGSLSTGGRVVAVKADLAKIALTQPVCTESGEKIALSRRVEKHWRLIGWGSIRRGITINADGTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3L0</accession>
    <name>A0A0D2X3L0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_005128</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346813.1">
        <property type="nucleotide sequence ID" value="XM_004346763.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3L0"/>
    <dbReference type="FunCoup" id="A0A0D2X3L0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3L0"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3L0"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3L0"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="184"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="304"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="379"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="505"/>
            <end position="509"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE94494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="541" mass="57689" checksum="6C3B58A02BB90CD9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3P6</accession>
    <name>A0A0D2X3P6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346971.1">
        <property type="nucleotide sequence ID" value="XM_004346921.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3P6"/>
    <dbReference type="FunCoup" id="A0A0D2X3P6">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3P6"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3P6"/>
    <dbReference type="OMA" id="QMTPPGV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3P6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255480" evidence="1">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="466" mass="51085" checksum="7060600E6222371A" modified="2015-04-29" version="1">MRSACALVALCLVAVAAVQPAAALPRPMDGLLRTLTAEYQQFCDSLEHSTMFPYRCTTDEKVAAKSQAMSALASVAAAKTLDPIIFFPGLTGSGFEAKFSKSSTVGAVCRANRDWFRLWMDAAQMLTPGCFLDSMDINYDPATDSYSNTEGVEIRAIDFGGVDGFEYLAYLYGVKLSIQDTYHDMVAAFKSAGYKPGQNLRGAVYDWRLPTDKLFGTGYGDLVQALIEDTYNRNGNSPVHIVSHSMGGPTSLFFLNSMTDAWKAKYIKSYIPISAPWSGSPSTLRSLLSGEALSLPINEEKFRLLFRAMTREAGGPVSLLPSINPEFWPADKVFVRTPTRSYTIADIPQLFIDAGTPITAQVYAKVKNVLTNLKAPNVPTHCVYGVDVPTQISYTYTSNWDDIPTIEYSNYGDGVVPIESLRRCQDWATQMTATIDINEIGLEAGNHFSIVQDPAVISYILSLTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X439</accession>
    <name>A0A0D2X439_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X439"/>
    <dbReference type="InParanoid" id="A0A0D2X439"/>
    <dbReference type="PhylomeDB" id="A0A0D2X439"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="933" mass="105074" checksum="919E2686B2BC724B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X478</accession>
    <name>A0A0D2X478_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X478"/>
    <dbReference type="STRING" id="595528.A0A0D2X478"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X478"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X478"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027251">
        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500231">
        <property type="entry name" value="Oat_dag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="551" mass="62890" checksum="9682CD1D28424305" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4M4</accession>
    <name>A0A0D2X4M4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tbpl2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344277.1">
        <property type="nucleotide sequence ID" value="XM_004344227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4M4"/>
    <dbReference type="FunCoup" id="A0A0D2X4M4">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4M4"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4M4"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4M4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="208" mass="23286" checksum="A1C137A1DCDD2246" modified="2015-04-29" version="1">MALQLQPPSQNENYEDYLRTSVVQPVLQNVVSTANLGVTLDLKTITMQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSREAARKFAKIIQKVGYKNAKFLDFKIQNMVASCDVKFPIRLEGLVLGHSTFASYEPEIFPGLVYHMVSPKVVLLIFVSGKVVLTGAKEKEQITTAFNNIYAVLKEYKKDVPQLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Y8</accession>
    <name>A0A0D2X4Y8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Y8"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Y8"/>
    <dbReference type="eggNOG" id="ENOG502QQD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Y8"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Y8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27383" checksum="D200E9F235C967A2" modified="2015-04-29" version="1">MKQQQHQQQHERQAPKNKNAAASSSSSSSSPSSSSTTTSSSSSSSSASAQKDTHQTTALQRHCEFFDRDGDGMISMRDTFTGCMSIGLGILVSAVSVLVINGLGAWFTSDSWWPTTTVHLKNIHRMMHGSDSGVYERNSGRLNHQRLDKLFQGNDAPDAAFTLRSFARHLVRDRLMLDIVGLIASCMEWLPLFFLNWRHYGTLSISRKTIEQMFDGSLFPELEKHWASKKQQQQQQKGKKDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5D9</accession>
    <name>A0A0D2X5D9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="22">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_009123</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270833.1">
        <property type="nucleotide sequence ID" value="XM_011272531.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5D9"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5D9"/>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5D9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255525" evidence="20">
        <location>
            <begin position="27"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1384"/>
            <end position="1660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1673" mass="176215" checksum="F07007F1CE7D0D9F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5J4</accession>
    <name>A0A0D2X5J4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270859.1">
        <property type="nucleotide sequence ID" value="XM_011272557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5J4"/>
    <dbReference type="STRING" id="595528.A0A0D2X5J4"/>
    <dbReference type="InParanoid" id="A0A0D2X5J4"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5J4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF3">
        <property type="entry name" value="BIFOCAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="725" mass="78655" checksum="F45F6528C02E5D2C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5Q3</accession>
    <name>A0A0D2X5Q3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342462.2">
        <property type="nucleotide sequence ID" value="XM_004342413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5Q3"/>
    <dbReference type="FunCoup" id="A0A0D2X5Q3">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5Q3"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5Q3"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5Q3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="376" mass="40926" checksum="FFB75096FBF938CB" modified="2015-04-29" version="1">MAERKVLNKYYPPDFDPSKLPRQQKKAQCKVRLMAPCNMWCNVCGNYIYKGLKFNARKETVAGESYLGIKVFRFYIRCPRCASECTFKTDPEHSDYVAEINLTRNLEPWREKLAREDEERKKRLADEEDNPMKALENRTLDSRREMELIEALEDIRDTNARHGRVDHNAMLDHYAKLQQQDLERQELEDETLVQNVFRKGAGAAGSLNSGPGGVKRRLAELQNSNGGAAKSALDGLDSEGYLNFSDDDDDDEDDDADSGIVVEDGLANVFSRAAAGAQPASNVLTGETSAAATHDAKRPKIEGFDAGPDKLIATGVTKLVGLVKKKTATTETAAKPAAPVAGGAASVSAPLLATSSAKPAPGGLSLLGGYASDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U063</accession>
    <name>A0A0D2U063_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365080.1">
        <property type="nucleotide sequence ID" value="XM_004365023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U063"/>
    <dbReference type="InParanoid" id="A0A0D2U063"/>
    <dbReference type="OrthoDB" id="1908104at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252374" description="Cystatin domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="154"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="445"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="683" mass="74107" checksum="06D03C69B01C628E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0L1</accession>
    <name>A0A0D2U0L1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365240.1">
        <property type="nucleotide sequence ID" value="XM_004365183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0L1"/>
    <dbReference type="STRING" id="595528.A0A0D2U0L1"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0L1"/>
    <dbReference type="OMA" id="MRLGCNQ"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0L1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="320" mass="34329" checksum="4EAFEBA42FE97E0F" modified="2015-04-29" version="1">MFRPILSQTAVTRAAIRSIATSAASANAAAPGSDKIVAPVRRLGVIGAGQMGIGIAQVAAQVAKIPVTVMDVSMPRLQQQLAFVDSLLAKNVAKGKMQESERKDIVSRFTLTTDIKDFASADFVVEAVSEKTDLKLDLFRQLSEVTSKDTILASNTSSISITKIASVTKNPENVIGVHFMNPVPVMKLVEIISGLQTSPETLQRSLALATAMGKTTATSQDVPGFIANRLLMPFINEAVFALQDGLGTREDIDATCRLGFSHPMGPLTLADFIGLDTCLAIMQILHSQLGDSKYRPANLLVKYVEAGWLGKKSGRGFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U383</accession>
    <name>A0A0D2U383_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365922.1">
        <property type="nucleotide sequence ID" value="XM_004365865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U383"/>
    <dbReference type="STRING" id="595528.A0A0D2U383"/>
    <dbReference type="eggNOG" id="ENOG502RCJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U383"/>
    <dbReference type="OMA" id="HIVAGMY"/>
    <dbReference type="OrthoDB" id="203754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U383"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037357">
        <property type="entry name" value="COMMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="23858" checksum="E1A906D70D73BF40" modified="2015-04-29" version="1">MSAAASDRTLFVGARIPVEIRKTTRLIEKLDKPTFRKLVQLALLELQGRAEDDSLVHGLATPTLSEETLAVVLTGITTILRCAIRQPRTSLKQDTFKEDLKELKFPPEFVVDLATIVYGQSREALEQSIHDYKPRHPTVDGLKWRTDVTISTSSLSRALKPTITLQLHLSDKSIKTVELSTDKFHELRYNVAYMLKEMEAVESKSILKIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5Y3</accession>
    <name>A0A0D2U5Y3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364704.2">
        <property type="nucleotide sequence ID" value="XM_004364647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5Y3"/>
    <dbReference type="FunCoup" id="A0A0D2U5Y3">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U5Y3"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5Y3"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5Y3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="206"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="684" mass="73552" checksum="12A868324515E4C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6L5</accession>
    <name>A0A0D2U6L5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6L5"/>
    <dbReference type="InParanoid" id="A0A0D2U6L5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="877"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1115" mass="117815" checksum="948343A9CE4C45D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE65</accession>
    <name>A0A0D2UE65_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE65"/>
    <dbReference type="InParanoid" id="A0A0D2UE65"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="145" mass="14414" checksum="DF2A56CD40986F74" modified="2015-04-29" version="1">MSGSPANAGSGDEVRDGKVPTLVVSSSDEPAATSAATTPVRKPALQMSKLRHTEGTNGAVGDASPASGHTANAAEHANASPSTPPATSAFRALPLASPSPLSLTSSASSSGLLPLANTLSHLLDAEMTSPEEDEEGNLSLDAWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEG2</accession>
    <name>A0A0D2UEG2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348116.2">
        <property type="nucleotide sequence ID" value="XM_004348066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEG2"/>
    <dbReference type="STRING" id="595528.A0A0D2UEG2"/>
    <dbReference type="InParanoid" id="A0A0D2UEG2"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="7">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="666" mass="71058" checksum="69876E326531E10D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF59</accession>
    <name>A0A0D2UF59_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF59"/>
    <dbReference type="FunCoup" id="A0A0D2UF59">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UF59"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UF59"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UF59"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="2">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="32442" checksum="643AD48C8B86F16F" modified="2015-04-29" version="1">MSRLATLKDIRTDEGDDHGHGSDDDDEPQQHYAGGSERSGQLIQDPSRRAGRGNDNLVQNVFRQAREQGASEVEDQPRRQRQAAFGGAGMRLGDGNEPPPQAGAASTAAAGAAAEEPASTKVHYRLTFWRDGFSVDDGPLRRFDDPQNAAFLADIQQGVAPRELIGNTNPGEVSISLVDNRTQEFVQVKKPAQAFAGTGYTLGTPTPNVIGTQAAGPSVSAAPTPAAPVSQLSVDPSQPTTSIQIRLADGTRSTIRTPWRTFATLWRRLDPVPSTFPNRELTDESQTIIAANLANAVLVQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK87</accession>
    <name>A0A0D2UK87_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine phosphorylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345555.1">
        <property type="nucleotide sequence ID" value="XM_004345505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK87"/>
    <dbReference type="STRING" id="595528.A0A0D2UK87"/>
    <dbReference type="eggNOG" id="KOG3728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UK87"/>
    <dbReference type="OMA" id="HPNICAG"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UK87"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="335" mass="36252" checksum="81A1007C059D7CE1" modified="2015-04-29" version="1">MNPLLRKDSVLPNAPLQLASNATAVAAAAAHHAAGLTSSIALDNPHVVKLDVDFLYHLGLDTSMDFKAMFGDVKFVCMGGSNNRMLEFAKRVAEELGITLPVGAAIADVSRTDRYCLYKVGPVISVSHGMGIPSISILLHEITKLMHYAGATEVIYLRIGSSGGIGVPAGTIVITEEALDGELNPFHTLKVLGNKIYRDAKFDRALLDEIAACKTPEMNVLVGKTMCAEDFYEGQARLDGAICEYPQDAKFAFFSKAQAKGVVNMEMESLEFAAFTWHLKIPAAVLCATYLNRMETDQVSSPPHVIHAYSENTQNLALAFMKKRLASYAARPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL16</accession>
    <name>A0A0D2UL16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006202</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345792.1">
        <property type="nucleotide sequence ID" value="XM_004345742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL16"/>
    <dbReference type="FunCoup" id="A0A0D2UL16">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UL16"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UL16"/>
    <dbReference type="OMA" id="EMGLFML"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UL16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="14">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="15">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE95786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="216" mass="25004" checksum="BB56030650207751" modified="2015-04-29" version="1">MALEWTFVYYLLITEVVIFALLCIPLPIRWRQAILSRIANSKTLLKLWPLALVVVAILSFLFFAALTEARATHREHEEHKRHNGYHHSGDMQTEIRMFRAQRNMYITGFALFLLVVLNRFYSLITELVRADVLASQARNQSETTVKALGDADKLKKENETLTQKLKESEEAKRKALVNVDNLVEQAKRNQAALDRHFEERQQEAQSSAPAERKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL19</accession>
    <name>A0A0D2UL19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270626.1">
        <property type="nucleotide sequence ID" value="XM_011272324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL19"/>
    <dbReference type="eggNOG" id="ENOG502S0WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UL19"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UL19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="891" mass="96630" checksum="097904442BD84C81" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL63</accession>
    <name>A0A0D2UL63_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270644.1">
        <property type="nucleotide sequence ID" value="XM_011272342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL63"/>
    <dbReference type="InParanoid" id="A0A0D2UL63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="449" mass="47745" checksum="3CDFA6073123B885" modified="2015-04-29" version="1">MSSDQLFSRFRRNKSGEDATKTKEDLQKDKQERDTVTSAVETRLAASTRSVRGKLEQLSWKGKAKVSAAVTSPIFNLTLWAEIEIGSVEGRISVSSNASTPMDDPSATNKQDESLLSELVEDDPDAGSSKRRGRLVRRFNQSVNDTLHRLESTSMCMQQLKINGDVGCRIYFLVPMPGLFINVKFTIDLSVSVESVVQAFSARGLSVAQLQATETAAVAATAPAAATATTGLFAQFASLRLGGSKSKIATTQPAADAGLTTSASDGFDVTKKAPRVQRQLLIALTAAQLRFLSMRWSGTIRVEISFPFLVLWVETSVEISESRAQITPAPAGAASVAGAASATSDAQDDVDEDADLLADDDSTAATSPASTDAAPSAVAADVMAAATSPLSAPVIHSGLRRSVDRLERLLVLYKQHFKAVSLGASFSLNIGGFGGLVELTVRRKFQHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULT5</accession>
    <name>A0A0D2ULT5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345174.1">
        <property type="nucleotide sequence ID" value="XM_004345124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULT5"/>
    <dbReference type="InParanoid" id="A0A0D2ULT5"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="38033" checksum="9D163396D806B9A8" modified="2015-04-29" version="1">MDSSTGSTSIVSADSCNTSDLIASLRQQLQECHAECERSHAALETEKSAQLRMTGEHLERVRVFESTIADQKVLIKQLHADVDHLELLMKIGPSASNPSAKNRDLTAQNRDLVIQNRQLSASVNRLTLEKSNLLQDAQTLQAKILALEATVAHQSSTILELKAKIAAQDEKIAGLETAFEEFKAQAATKEAQAAAKEALLNLGASMSTLVNHVLKEAFPDRAARRDAFDVCAENFSGRGRYSPALLSGGRLTEVSNTVRDDDEAEIKKLKEHFTTTKWSFRSFMVAYWLLIAYGLRSRFHALAHYGAGKTTEQLKAEMSQLPEEYRLYAQEDLDSILSLPWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMN3</accession>
    <name>A0A0D2UMN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMN3"/>
    <dbReference type="InParanoid" id="A0A0D2UMN3"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="33211" checksum="6534BAB3B0AC517C" modified="2015-04-29" version="1">MVSPSGSTHTSSPLGDAADSIDSLRQQLEECHESCERSRKALEAEKAALQANLVTTTDQHVFRVKELESVILSQRKLLKQLQSNAEIETDSASNRNLATQNRELVTQNRQLSSSERDTLLQKVEALEAQLAVQASEIVNLRARIVEQAGSFDRFKTQVVAEIAALKTAFDQFKAQADKKEALLNLGDSMCTLVNHVLDEAFPEDDANFKAYRADDDDEEIKQLKQHFTDTMWEFRSFMVAYWLRTERHSVTHASAHKTPDELKAYMTKLPEAYALRAQKDLNSIIEMADLIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPE4</accession>
    <name>A0A0D2UPE4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPE4"/>
    <dbReference type="STRING" id="595528.A0A0D2UPE4"/>
    <dbReference type="eggNOG" id="KOG2921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPE4"/>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPE4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252980" description="Endopeptidase S2P" evidence="7">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="8">
        <location>
            <begin position="130"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="475" mass="52580" checksum="EBB1249509799931" modified="2015-04-29" version="1">MSLAQTSVALACGWAAILGAHTVLKRCIGEPYKALLARLGISLSVGQLRIHSNALNRWFMAVGRRFARFWSAWFLLSVGFGWLGMLGSIALLTANLIQALAPRTILESDVQMLSPVIPGVNVPTNHLAYYFLALAISGFCHEAGHALAAASHSVTVEGFGAFVTVLYPGCYVSLNDDQMNAISPLRQLKIYCAGVWHNAMVALLAVIGLMSITVLVWPAFAYNTGALTVVDVMEDSPLYSSLHIGDRVRSIDRVCSLSLRGDWGRCLTERRSVPVEAKGYCIPENDLREWDTAVRPWRDDGVLPPCWDQGLIFPLYLKLACLPVRRSILDRNRCTSKADCTPGDVCIHVEGESEQQQLITLEVEGRAPVMFLGDPYVLAYTVHLSDYAPRMRYFSAQWPIRLEMLLRYTLSLSAALALLNMLPTYYLDGQWALYASVDFFLGRIVPQSRRLAICNAILIFSLVLFVANMLAMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQH7</accession>
    <name>A0A0D2UQH7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQH7"/>
    <dbReference type="FunCoup" id="A0A0D2UQH7">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQH7"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQH7"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQH7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="43553" checksum="65E1C33C856E6654" modified="2015-04-29" version="1">MDDGPLLARFLSVLSIYPCSIPKFSTCILQIHSLHFSFIFGCLCCFLRFFTCLTRMSDDSSVLRKRLAFAIIEHLASEVASKAFPEEATESLEVAIQCLSQVYDVDKDDPAQQAALTIRPANLQRLFKMFVSTASATKQAAPAGDAAKSSPVSHHNVDAGAKPSDASTAERAAEAEKLKAEGNERLNSLDYDGAVKKYSLAIDLNPTNAVYFANRAAAYTNLKRFKDAVEDSHTAISLDPTYSKAHARLGHAYFALRQYDASISAYKSALEIEPNNSSYLTNLKAAEKASQEEGGVEAAAPRGGNAPAAAPGGFDIGSLLSNPNLMNMASQFMSSPAAANLMSNPMFANLASSFMGGAGAGAGAGAGAGAASANPDDDGEDDGATPGAAGGQMPDLSALLNNPALRNMFAGGAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT15</accession>
    <name>A0A0D2UT15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT15"/>
    <dbReference type="STRING" id="595528.A0A0D2UT15"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UT15"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="229"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE98086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="563" mass="62336" checksum="88192608A41F5CC7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT50</accession>
    <name>A0A0D2UT50_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT50"/>
    <dbReference type="STRING" id="595528.A0A0D2UT50"/>
    <dbReference type="eggNOG" id="ENOG502QUAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UT50"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UT50"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="178" mass="19750" checksum="14A63CAC5E33BA9B" modified="2015-04-29" version="1">MSETSSSVGGDDYYAFISDTEDVDQAELELDEALNESVSVVVIDQQELGKAIAAAIRVGNFMHKASVLSGLACLGTGLLSRWLRLNFWGLTLPAGVISVTCALFYDLSWRTDPCCKYQVVDWNGLEFQNIPLERLQSTNPVVLVRRDDTIRKRLHNIVSFSSAVFCGARLFQAVRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFF0</accession>
    <name>A0A0D2VFF0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364982.2">
        <property type="nucleotide sequence ID" value="XM_004364925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFF0"/>
    <dbReference type="STRING" id="595528.A0A0D2VFF0"/>
    <dbReference type="eggNOG" id="KOG3733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFF0"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFF0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="8">
        <location>
            <begin position="579"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1032" mass="109094" checksum="46BD9D45489EA498" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFY2</accession>
    <name>A0A0D2VFY2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365150.1">
        <property type="nucleotide sequence ID" value="XM_004365093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFY2"/>
    <dbReference type="FunCoup" id="A0A0D2VFY2">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFY2"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFY2"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFY2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="432" mass="47018" checksum="81EA12B7FF178248" modified="2015-04-29" version="1">MSDAAAPAPAAEPVTATAAAAGQSSQQQPSKVAPAVLVIGMAGAGKSMVMQRLSSHLSENRLKTYGINLDPAVVGDLSFPANIDIRDTIHYKKLMEEHNLGPNGAIVLSLNLFTTQFDQLSNLLAQRALENDFVLIDTPGQIEIFTWSAGGAIICDALASRLPTCVVYVVDTVRCQNPVTFMSNMLYTCSILYKTQLPFVVVFNKTDIVKHDFAVEWMRDFEAFEEAVSRESSYTSGLARSLSLVLDEFYSNLRVVGISAARGDGMNDLVEAINEASAEFERDYRPKLEQLRKEKEAEEAARQQAQLNKFAADKNAGMKVAMNLSDAATAVSAAAGASGSRKAQVKLSKINYGKGSHEEYDSDDSDSAYTPRDGLSYMNENEEDEDDADDDEAEGDEYSTAEEAEKERLQFESFKSFLASQNASSAVAKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGF8</accession>
    <name>A0A0D2VGF8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGF8"/>
    <dbReference type="STRING" id="595528.A0A0D2VGF8"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGF8"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="275" mass="31023" checksum="3353648BDFF34D60" modified="2015-04-29" version="1">MAMIGVFQGLRAIGQKEGLLGYYKGNGAMMARIFPYAAIQFMSYEQYKKLLKSYFNGRESPVHRLLAGSLAGVTCVTFTYPLDLVRARLAFQVSENRYTGIAHAFRTIYAEEGGLRAMFSGFRPTIYGMIPYAGLSFFTNETLKAFFLENMTSITTKPVHKRDGTAPDPTLRELTYTTNLLCGGIAGGVAQTFAYPFDVVRRRMQLNRGLPDGQATSTIRTLVYILRHDGFFRGWYRGMSLNYMRVVPQAAVSFTTYEFLKRMLQIEDRSIVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGW4</accession>
    <name>A0A0D2VGW4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365525.1">
        <property type="nucleotide sequence ID" value="XM_004365468.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2VGW4">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGW4"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGW4"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGW4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="471"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1561"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1566"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1592"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1614"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1641"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1678"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1900" mass="206012" checksum="EB42682540D5BF3E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLJ7</accession>
    <name>A0A0D2VLJ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLJ7"/>
    <dbReference type="STRING" id="595528.A0A0D2VLJ7"/>
    <dbReference type="eggNOG" id="KOG0551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLJ7"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLJ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="277"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="400" mass="44089" checksum="8F1A4E71C0582D26" modified="2015-04-29" version="1">MELKALDGKQSARVDMEKVPLFMTKSPDHIDPDASPALAALAAIIHEETTPDDKVEYYKEQGNALYKKATRDELKKAVIMYSEGLSVPDAVNMQLRATMYLNRAAANIQLGNNRAALADTTLAKKTDPANIKTYARAAKACLALGQHTEGIQWCDEGLALDATNKPIQEERVKLVKAQGEAQRKQRMEAKRLREVAAQETRIHAAILNRNIKMKAHPMHEEEEQKAAAEAAASGASASDPSPVASIANDANNKGTAQAVKLFRLENPSGVKPTLNEDGSLCWPVFFLYPEYEQSELVSSFHEQATIGEQMENMFPDDAPPAPWDSNKFYTRHDALEVFFEEQLPANAKSGTIPKLVRVSKSKPLLQVLADPRYVVIGGTPTFVVLSSQSPFRAKYLSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNX2</accession>
    <name>A0A0D2VNX2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNX2"/>
    <dbReference type="InParanoid" id="A0A0D2VNX2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="79" mass="8548" checksum="49081A6F7995BB4D" modified="2015-04-29" version="1">MPQNSPVQKVQLRPDHLHRPISAVTFIVCTVLVGLALASSLNGRAFICAGVDFAKRDIRQGAPSLFPLVPSGMLFSIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPA3</accession>
    <name>A0A0D2VPA3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="12">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009646</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="12"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPA3"/>
    <dbReference type="STRING" id="595528.A0A0D2VPA3"/>
    <dbReference type="InParanoid" id="A0A0D2VPA3"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPA3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="157" mass="17727" checksum="FF65AD4D49605A5C" modified="2015-04-29" version="1">MAASAAAAAATRQLTLAVIKPDLFANPARVQAIMDVIQEHRFEIKHSAVVRWTRADAERFYAEHHGKFFFNRLTGYMSSGPMQPMVLEREDAIRYWRLLMGPTHPARARQNSPNTLRSIYGLSDTRNSLHGSDSKASALREIGFFFPDLPIDWPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ44</accession>
    <name>A0A0D2VQ44_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ44"/>
    <dbReference type="FunCoup" id="A0A0D2VQ44">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQ44"/>
    <dbReference type="eggNOG" id="KOG2325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ44"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="141"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="64510" checksum="2FE86306EE495F91" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ78</accession>
    <name>A0A0D2VQ78_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arfip1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363388.1">
        <property type="nucleotide sequence ID" value="XM_004363331.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ78"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ78"/>
    <dbReference type="eggNOG" id="KOG3876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ78"/>
    <dbReference type="OMA" id="NARINYD"/>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ78"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000085">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="150"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="409" mass="43895" checksum="09608793482CD6B5" modified="2015-04-29" version="1">MSSSSSSEMPVDNANAIPADSDAAVSDAPVTAASITAPDANAQAKAADLAGSSSSSSATSSSPSQHAPARPPPPYTQHAQHQPSAAATTQTGQQQQQQQQRGGADPASSSLPVQHHQSAAARGTLMDWGYETYAFTRQFLTEKLGGGSYTVDIELQRKIDTMRDNHTQCKRLLQLAESYVNNFTTLVGTQHQLGSLFAEAAIKTPALATEFSFNHATQVALQKNGRVLLAALRFFASNLHTLCNKTMEDTFDTLKEFENARINYDAFRIDLERMQASGKGLTKSAQDARERFDAAKGKFDAVRIQLNIKMRLLDENRVKVLQKQLLLFHNAISAYFSGNQEALASTMHQFLVPAPEPSAFLAGENPLHNLPQLPVLDNQPPITLPSTSSSQPTSAGDDASGNSTASAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQA6</accession>
    <name>A0A0D2VQA6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363430.1">
        <property type="nucleotide sequence ID" value="XM_004363373.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQA6"/>
    <dbReference type="eggNOG" id="KOG3621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQA6"/>
    <dbReference type="OMA" id="KYTCLDV"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16484">
        <property type="entry name" value="RING-H2_Vps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="2013"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2065" mass="215179" checksum="8ABB6770F00DD237" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQZ0</accession>
    <name>A0A0D2VQZ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347878.2">
        <property type="nucleotide sequence ID" value="XM_004347828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQZ0"/>
    <dbReference type="STRING" id="595528.A0A0D2VQZ0"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQZ0"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012891">
        <property type="entry name" value="GCK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01227">
        <property type="entry name" value="GCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GCK" evidence="10">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="163" mass="17600" checksum="E756612B69C2B81D" modified="2015-04-29" version="1">MCSAAKDQVIFLTKEEEAAQPKEAIQPDNGDFRQAVGPNGEIDWDCPCIKPMTEGPCGLEFKDAFSCFVKSKEEIKGSDCIEAFRLMQTCMASHPEEYGGNKDADAEDEADINAAVLASQEAELDANPADLPVEEPAASQPQAIVASSIDESSSSSSSGWWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRU9</accession>
    <name>A0A0D2VRU9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear transport factor 2</fullName>
            <shortName evidence="1">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348224.1">
        <property type="nucleotide sequence ID" value="XM_004348174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRU9"/>
    <dbReference type="FunCoup" id="A0A0D2VRU9">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRU9"/>
    <dbReference type="eggNOG" id="KOG4353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRU9"/>
    <dbReference type="OMA" id="HFTRLYY"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="129" mass="14242" checksum="FD5BBBE42F5F1B6E" modified="2015-04-29" version="1">MSQAIHDAAVAGDSLVAEFYERYQTQRDNLVQLYSDSSSVMWNGNLYYGTEAIRGLLAQLPQCRFSIHSYDAQPITAAASGNIAVTMVSVAGYVQYANSSPKPFSHTFVIQIDVTSNALFIQSECMRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSV4</accession>
    <name>A0A0D2VSV4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSV4"/>
    <dbReference type="InParanoid" id="A0A0D2VSV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="120" mass="13553" checksum="204DBDADE248CA81" modified="2015-04-29" version="1">MRHKTCSISCQSIGCWGTCSAAESAAQEAKRCADWGLLCIDRRNEKLVWKDEQKRIAWSQQLANKRMDRTLRMPFFVTSASDLAVASKGRGRGRGQEGNIGRNLQNKKTEQLETPKIQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU94</accession>
    <name>A0A0D2VU94_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU94"/>
    <dbReference type="STRING" id="595528.A0A0D2VU94"/>
    <dbReference type="InParanoid" id="A0A0D2VU94"/>
    <dbReference type="OrthoDB" id="2372305at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VU94"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024857">
        <property type="entry name" value="Cappuccino"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230:SF3">
        <property type="entry name" value="BIOGENESIS OF LYSOSOMAL ORGANELLES COMPLEX-1, SUBUNIT 4, CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230">
        <property type="entry name" value="CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="25489" checksum="0380C7EB3F0EEBEA" modified="2015-04-29" version="1">MSEAASTLSPAAASALATAAAIEAEAASIDAATATTVAAASVDTTTGATAGGASAAAPEMASPVTIAAAAVAAAQVEIDLSAASAKAAADYAQFLRFENLGEITAVATNVDDMLKKLDEMRSLSETLHRDSLVTIQTHLPYLMKNTAKLQGLFAYIEQVEKYINHIKGFVSRLEERLDQAEKDFQSRSIKKVFDGFKLPSLFGKKSMEVPVAAPPGRFHPVEVFATEDYFPARESDVVAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX59</accession>
    <name>A0A0D2VX59_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345300.1">
        <property type="nucleotide sequence ID" value="XM_004345250.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX59"/>
    <dbReference type="STRING" id="595528.A0A0D2VX59"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX59"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX59"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="697" mass="73132" checksum="E87F0B128EFEEC7E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXB8</accession>
    <name>A0A0D2VXB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344246.1">
        <property type="nucleotide sequence ID" value="XM_004344196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXB8"/>
    <dbReference type="eggNOG" id="ENOG502SFFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VXB8"/>
    <dbReference type="OrthoDB" id="2019083at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF86">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56263" checksum="CA5490D1DE20D6C4" modified="2015-04-29" version="1">MLGFGLLRRRRRVLSLLLAACVLIGIVVSMNYSFDSLDARRLRNAVTERNPMHAQQAALQPNRHGHAGGRHPADEPRDDAGNDSDIDNETERDDERDDGLVAQPPLFEPRLSHNERRRLAKLDLINKNNNNNNNNGEQVPPQLRKANHGGPARPQQQQQVEKVKANALADLNARLANAAAAKNNENQNNEAQDKAEGVGRDPVQGGPPNRFSDVCDPWCSMERRAYPPPAAQPYFLTGVLLMRIYDEDKADLTFKEMLQWIAYMQYAGVEHIYVYDAYFQSMPHEKQEARLKPYIDGGYITYYDWSRYNPYSIDGTQVRAYQDCLTRHGRESTWTVAMDIDEYPFVLQDFEPGFFARYIREYSKKNPHVSEITAQNFLFLEGPIPKAQNDLLMERIRRRTPHAHNALVKPTYRNADLGGCQVHHNYVRTGSSQDAPPSEYRMNHMWGARLQNWNPITPKSILDMTVADDSMLALSARVSPCICYPRTGVRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYA5</accession>
    <name>A0A0D2VYA5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006963</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343687.2">
        <property type="nucleotide sequence ID" value="XM_004343637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYA5"/>
    <dbReference type="FunCoup" id="A0A0D2VYA5">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYA5"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYA5"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYA5"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="15">
        <location>
            <begin position="187"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE96682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="353" mass="40144" checksum="9CBC923693FE5A34" modified="2015-04-29" version="1">MSESSSFSLTDHPHRRLNLLNGKWILCSPHRAKRPWQGQQEKTSGSTRPEYDPNCYLCPGNKRVTGELNDKYEHTFAFRNDFSALLSDTPAGSVSEGDGLLVAQSTRGRCHVMCFSPKHNLTMAQMSTEEITGVVHEWMRQQKELSAEYEYTQLFENKGEVMGCSNPHPHGQVWASDTVPEEVSQEVASFRLHRADKHSCLLCDYLALELSKQERIVLENDSFVVLVPWWAYWPFETLVLPRTHTSSIAQLDEKQQVDLAAILQKLTCKYDNVFECSFPYSMGIHSSPNSMLASGEYHMHMHFYPPLLRSASVKKFLVGYEMVADICRDITAEQAAERLRSLPTVHYTVSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZQ5</accession>
    <name>A0A0D2VZQ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZQ5"/>
    <dbReference type="eggNOG" id="KOG1011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZQ5"/>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="363"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="10">
        <location>
            <begin position="787"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1435" mass="155010" checksum="DEC723E0E64AB9BB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZT2</accession>
    <name>A0A0D2VZT2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343116.2">
        <property type="nucleotide sequence ID" value="XM_004343066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZT2"/>
    <dbReference type="STRING" id="595528.A0A0D2VZT2"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZT2"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="113"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="446"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="529" mass="57742" checksum="2D529F4B26C193A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZZ4</accession>
    <name>A0A0D2VZZ4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343176.1">
        <property type="nucleotide sequence ID" value="XM_004343126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZZ4"/>
    <dbReference type="STRING" id="595528.A0A0D2VZZ4"/>
    <dbReference type="eggNOG" id="KOG3082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZZ4"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZZ4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="3">
        <location>
            <begin position="370"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="528" mass="57003" checksum="271E11C79FB63D17" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W030</accession>
    <name>A0A0D2W030_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343213.2">
        <property type="nucleotide sequence ID" value="XM_004343163.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W030"/>
    <dbReference type="InParanoid" id="A0A0D2W030"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W030"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="223" mass="24060" checksum="148438DADC1BAD7E" modified="2015-04-29" version="1">MSITDALLKKVQAASGLGFGSFLVLHLCNTLSGHISPAVYDSVQSVLRCYYQNPAVELVMVFGSLSIHVGASLWRMQKRVAADAVLAQSLKHELSTADVSATSAPDPKAVRAAAAGPDTMTLSLVRKLHRLSGLALLPLISVHVMATRLSPIVSGVVPDMTIVTGSSVWKAFVPLGALLVSSVLAMTGYYWHIATPRVYTDYVQLHEVYMQYVPDVVRKHLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1L4</accession>
    <name>A0A0D2W1L4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1L4"/>
    <dbReference type="STRING" id="595528.A0A0D2W1L4"/>
    <dbReference type="eggNOG" id="ENOG502S42V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1L4"/>
    <dbReference type="OrthoDB" id="6502630at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1L4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048897">
        <property type="entry name" value="Nol11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20998">
        <property type="entry name" value="Nol11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 11 C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="57169" checksum="B6F7D13E48B0ACB8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGC7</accession>
    <name>A0A0D2WGC7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364981.2">
        <property type="nucleotide sequence ID" value="XM_004364924.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGC7"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGC7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000016">
        <property type="entry name" value="Adenylate/guanylate cyclase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1361" mass="146889" checksum="B0CF472C71BEB68F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGH2</accession>
    <name>A0A0D2WGH2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365029.1">
        <property type="nucleotide sequence ID" value="XM_004364972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGH2"/>
    <dbReference type="InParanoid" id="A0A0D2WGH2"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="425" mass="45521" checksum="B72BBA3063F3CD33" modified="2015-04-29" version="1">MLQASTALVRAAVPWKQTALLLSSTSVAASGAAASGAASAIAVRSCPMARSHSSLTARRSAAITATAASAAATAATATSATVSTATVASSPSLSSSSSSSRMFGSLATLRPRAAAPAAGSAASLASASSQRYTRRNALARAVERDPSPANASANASASLTQPPQSSQQATRSADASPSAASSDSEAAFQSEGYDQAEDELEEVYKVDETDLWDELDEEVQAELLFKFQTSIDELTPAERIVLLRRFGPSLWDEGDDRQVYQPHTWTHIAATERRPAQIGLPGVLPVNPNGATGFYTEDKSFKEAVRKSTFTKRIPLPRGDMTVELFLTRIGNEAVSHLAKFPSWFALMGYSSRQMNALGIPIATRRYICEWRDRYSRGVEPYVIKRTPWKKLKDRKAQRIERRANARRVAQGLAPNKPKAAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGN1</accession>
    <name>A0A0D2WGN1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGN1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1535"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2746"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1870"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1991"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2104"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2174"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2292"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2470"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2632"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2754"/>
            <end position="2766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2795" mass="301845" checksum="77D0A1154958D182" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGN6</accession>
    <name>A0A0D2WGN6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGN6"/>
    <dbReference type="STRING" id="595528.A0A0D2WGN6"/>
    <dbReference type="InParanoid" id="A0A0D2WGN6"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266360" evidence="10">
        <location>
            <begin position="28"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="524"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="815" mass="87284" checksum="5E699D10756E6B68" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHN3</accession>
    <name>A0A0D2WHN3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270005.1">
        <property type="nucleotide sequence ID" value="XM_011271703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHN3"/>
    <dbReference type="FunCoup" id="A0A0D2WHN3">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHN3"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHN3"/>
    <dbReference type="OMA" id="HMVNTDA"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="67"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="322" mass="36092" checksum="891B9403B6DE1680" modified="2015-04-29" version="1">MIDLGTVMAVLAVLALVALIVLIAALWYTSPVLHPRSGTELSFVNPASGGRQDFPSLLRDPATVDLSLIVPAYNEEKRIDLMLEDALGVLEKRPAPFKYEVILVDDGSKDGTTAKGLDYVRKYGSDKIRVLTFTRNRGKGGAIRMGMLSARGKYLLFADADGATSFKDVVRLEDALKQHEAKNEHAMAIGSRAHMQDDAVANRTLLRNILMYGFHILVFLVGIRGIRDTQCGFKMFTRPAARVLFPAMHVERWCFDIELLFLALRLGYPVAETAVNWQEIDGSKLDPIWSSVQMFKDILLIRLYYLFGIWQLPRSMDAKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI04</accession>
    <name>A0A0D2WI04_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI04"/>
    <dbReference type="STRING" id="595528.A0A0D2WI04"/>
    <dbReference type="eggNOG" id="ENOG502S2FH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI04"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="456" mass="49323" checksum="89554089A951A9C3" modified="2015-04-29" version="1">MLHPGAPELTPEQTFAASLRGRLVTRDSPDYEQICASWNAELKKHPKYIVQARTNTDVIAAIKFAQANNLEVTARCGGHSLRCLVDDGLVIDLRQMSMVRVEADKKIVHVGGGAQLGDVDAELSLHNLVVPAGIVSDTGVGGLALVGGVGWMARSYGLTCDNIIGLDVVTAEGKLIRVTADNEYKDLFWGMKGAGTAFGIVTSFTFKAHEFGAGAATVFGGALIFPFPRAQEILTKFNEFTKTMPDALALYAVCVNAPPGPVVILEFCYNGKEEDGRPLVQPLIDLGPIMQAGVGTVPWTTWQRAKDTLAPHGGNYYEAGLNLNELSEGFIKKLMEAFPRSPSPQSFFLLESNGGAMSRVPNDSAAIAWRHAAFTIVFFAAWPADTEAEANKAWLRETRTSLMPFHTGTLYANFSSEGTAVESYGQQMLARLVELKQKYDPTNFFHVATFGNLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIM5</accession>
    <name>A0A0D2WIM5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366012.1">
        <property type="nucleotide sequence ID" value="XM_004365955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIM5"/>
    <dbReference type="InParanoid" id="A0A0D2WIM5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="2">
        <location>
            <begin position="529"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="910" mass="96567" checksum="FDF1601C5EBFDFC9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJT5</accession>
    <name>A0A0D2WJT5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="9">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365992.2">
        <property type="nucleotide sequence ID" value="XM_004365935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJT5"/>
    <dbReference type="SMR" id="A0A0D2WJT5"/>
    <dbReference type="FunCoup" id="A0A0D2WJT5">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJT5"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJT5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="103"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="363" mass="39089" checksum="70A3A9429E7918E8" modified="2015-04-29" version="1">MDSFIGLLQSNSSYILAVAAIAFTWMVAQKMGGGGAPGSGNSRGAAASCPFVNSGAAAASSTSTATATNTEVASAAAGQAPPKLSPGHPRVTAEGRLIALDPENKIAFKLVKKEHISHDTRRFRFALQSPEHVLGLPIGKHMNLSANIGDQLVVRPYTPTSSDDDLGYFELVVKVYFKNVHPKFPEGGKMSQYLEGLRIGDTVDVIGPKGRITYQGNGRLSVCEINKPEAFRQAKHFGLIAGGTGITPMLQVIAAVLKNPKDTTTLSLLFANQTENDILVRDMLEQYARDHPTRFKVWYTLDKAPAGWKFSEGFINADMIAEHLPAATPDAQILMCGPPPMINFACIPNLEKLGFTAEQFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK63</accession>
    <name>A0A0D2WK63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349866.1">
        <property type="nucleotide sequence ID" value="XM_004349816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK63"/>
    <dbReference type="STRING" id="595528.A0A0D2WK63"/>
    <dbReference type="eggNOG" id="ENOG502QWR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK63"/>
    <dbReference type="OMA" id="ENELHAD"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="533"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="791" mass="82819" checksum="56396C312359A4E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW2</accession>
    <name>A0A0D2WKW2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_001676</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364544.1">
        <property type="nucleotide sequence ID" value="XM_004364487.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKW2"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKW2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKW2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254541" description="receptor protein-tyrosine kinase" evidence="17">
        <location>
            <begin position="33"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="261"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="447"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1061"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="933"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE90353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1351" mass="144149" checksum="A0062D68D4F4A1C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKW3</accession>
    <name>A0A0D2WKW3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348978.2">
        <property type="nucleotide sequence ID" value="XM_004348928.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKW3"/>
    <dbReference type="InParanoid" id="A0A0D2WKW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1145" mass="119457" checksum="6F4D47472FBCF20B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLG2</accession>
    <name>A0A0D2WLG2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAMK/TRBL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364816.1">
        <property type="nucleotide sequence ID" value="XM_004364759.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLG2"/>
    <dbReference type="STRING" id="595528.A0A0D2WLG2"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLG2"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="530" mass="56813" checksum="3A2CD4D70C4FA03B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLM3</accession>
    <name>A0A0D2WLM3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002062</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348812.1">
        <property type="nucleotide sequence ID" value="XM_004348762.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLM3"/>
    <dbReference type="STRING" id="595528.A0A0D2WLM3"/>
    <dbReference type="eggNOG" id="ENOG502QTNG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLM3"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLM3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="194"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE90818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="566" mass="63345" checksum="DB7A98F64BF08A78" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMG7</accession>
    <name>A0A0D2WMG7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Meiotic recombination protein SPO11-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_003056</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363895.2">
        <property type="nucleotide sequence ID" value="XM_004363838.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMG7"/>
    <dbReference type="FunCoup" id="A0A0D2WMG7">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMG7"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMG7"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000387">
        <property type="entry name" value="DNA topoisomerase 6 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase 6 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF4">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 14 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="15">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="16">
        <location>
            <begin position="243"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE92020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="46405" checksum="1641B155EBB6BB01" modified="2015-04-29" version="1">MGVNSGTVAVLSKASVSKRKGPLAVASKDAAVVLQEVNKLAKAQQQSVKHRATLEELGISDAREVAVMDDADVAQTIERIVIQAAQSILAGTGFSYDVPSRASSNQLYVPQLERIVLKSAVSNRPFSSTATVRKTAITTRVLSLVHEVLNKRIHITKRDLFYTDVKLFEKQNDSDAVLDDVACMIGCTRTSLNVVASEKGVVIGRVTFRDDGDFIDCTKMGVGGKAIPSLIDRITDLQGDAQFVLLVEKDAAFMRLSEDRFYNQYPCIIITARGQPDVSTRLFLNMVKTRLNIPILGLVDSDPYGLKILSVYLSGSKNMSYDSASLTTSDIKWLGVRPSDLETYNIPKECRLDMTESDIKYGQDLLKEDFIKNNPAWMAELELMLKTKEKAEIQALSNFGFQYLTQTYLPLKLQQGDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMQ6</accession>
    <name>A0A0D2WMQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364042.1">
        <property type="nucleotide sequence ID" value="XM_004363985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMQ6"/>
    <dbReference type="InParanoid" id="A0A0D2WMQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="272" mass="29881" checksum="2EAF546D7085B950" modified="2015-04-29" version="1">MFGDLHARYPKWFLPKHLRQALKSAQTKTPEQLSAGTTDTDEGVELWFQNRLLALVTSHKHHEVNDVLYKVYDSARGLNNNAKKRATARTPDAQESVMVEAQQVADSIAMSQPLPDIDLSAGATDDINFHTEPSSDDDSNNSSDDSNNNNNVSSSESLLTNSNLAAADESEDDDAHPASSDSGLAAASSDSESHEANDRVTSAEIDDQDDSRQDNNCTGGLVRRRSNRDYRPAHNVSRSSKRMRFCTEGEQSGPRRHQTRAQRAASRALQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN22</accession>
    <name>A0A0D2WN22_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364245.2">
        <property type="nucleotide sequence ID" value="XM_004364188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN22"/>
    <dbReference type="STRING" id="595528.A0A0D2WN22"/>
    <dbReference type="eggNOG" id="KOG2129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN22"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="409" mass="47050" checksum="CB38D6340514ACBA" modified="2015-04-29" version="1">MSGVGAVQHSASDPGPPTARPTYEQLEEENERLRRELDIERGRVVHLQSDIAQVRKQSMDMQLQVEAEEEHIALTLLKRIDQLQKSKEALALQVEREEEYLTNTLQKKLLQLQHEKEHLEKILEHEQENVVNKMKQQVDQLQREKVLMSSKLSKLQNEKVQIENALEQEQEFMINKLTKQIEHLRSDKKHLQEELFKSPRSSGTDLSSEIQSLRRQLQENEAKRTASQQTSSHDLEELHLENLHLRQRLARELERVEALASEKTLDEFEKETSEERMFNHQLTDEFDSRRFRSHSNPTPPSHAPPARRGSIDTSIAEPKWWSERTPSISKDRDDGAPHISPHSSMHGLQLPSPQLSPIQHHHQHHHASPHGHGILLHSMSSPAGSHLSTTTAHAHDLHSPGSATVHSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPB4</accession>
    <name>A0A0D2WPB4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein rab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPB4"/>
    <dbReference type="STRING" id="595528.A0A0D2WPB4"/>
    <dbReference type="InParanoid" id="A0A0D2WPB4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="25872" checksum="F9844C7FE5013D74" modified="2015-04-29" version="1">MASGSPSGAAQQQQQQQQQQQQGGGRALEAKVVILGSQGVGKTSLVLRYVQGTYAADITSTIGASFMTRKMTVDRCQVRMQIWDTAGQERFRSMAPMYYRGANAALLVYDITDEQTFDDIKSWVKGERSNTSERPLDFEMPCSHCTLSSIPLLVAIELQHNVDSDIVLVLVGNKSDMASQRKVSGETAAIYAEEINALFFETSAKADSGRSRVFKSSLIAFCSHAQLFVLLLTNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPJ8</accession>
    <name>A0A0D2WPJ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348427.1">
        <property type="nucleotide sequence ID" value="XM_004348377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPJ8"/>
    <dbReference type="InParanoid" id="A0A0D2WPJ8"/>
    <dbReference type="OMA" id="VADCAYA"/>
    <dbReference type="OrthoDB" id="194033at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052491">
        <property type="entry name" value="TNFRSF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330:SF6">
        <property type="entry name" value="HEMATOPOIETIC DEATH RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395746" description="TNFR-Cys domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="565"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="565"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="904"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="913"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="959" mass="97777" checksum="96A57635C9AE649C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ14</accession>
    <name>A0A0D2WQ14_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ14"/>
    <dbReference type="InParanoid" id="A0A0D2WQ14"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="537" mass="58221" checksum="B56F3EC3B78E9895" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQJ5</accession>
    <name>A0A0D2WQJ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004033</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347858.1">
        <property type="nucleotide sequence ID" value="XM_004347808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQJ5"/>
    <dbReference type="FunCoup" id="A0A0D2WQJ5">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQJ5"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQJ5"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQJ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000382">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="634"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="781"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE93213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="896" mass="98057" checksum="4B0E1475E2E81B22" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQX7</accession>
    <name>A0A0D2WQX7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQX7"/>
    <dbReference type="InParanoid" id="A0A0D2WQX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="10308" checksum="3EEA5BCE3BFD120F" modified="2015-04-29" version="1">MLETNDAMKEEEVVVVEVAASDGGGDGGLARGVLLALLTPILDLVADKMLMNSVLGTAVASSSCPGEGQAPDMLLLLLPSVAEEVGGRADVGGGAWSRITVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRD8</accession>
    <name>A0A0D2WRD8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cathepsin L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347262.1">
        <property type="nucleotide sequence ID" value="XM_004347212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRD8"/>
    <dbReference type="STRING" id="595528.A0A0D2WRD8"/>
    <dbReference type="MEROPS" id="C01.092"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRD8"/>
    <dbReference type="OMA" id="HNGEYSE"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRD8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018599892" evidence="6">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="108"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="324" mass="34428" checksum="25A56BC66BCDA0A4" modified="2015-04-29" version="1">MKAFTAVALLALVACAAANPCFDSWKATHGVSYATVGEETARRGIYRANLDFIEKHNSEGHSYKLAVNKFADLTYPEFAAKYLGLRFDATNATKSFAASTYLPRMVSLPDSVDWRTAGIVTPIKDQGQCGSCWSFSTTGSVEGQHARKTGQLVSLSEQNLVDCSSAQGNAGCNGGLMDQAFQYIISNNGIDTESSYPYTAQDGTCQFNSANVGATVASYQDIASGSESDLQNAVATVGPISVAIDASQPSFQFYSSGVYNEPACSSSQLDHGVLAVGYGTSGSSDYWLVKNSWGTSWGQSGYIWMTRNSNNQCGIATAASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRH5</accession>
    <name>A0A0D2WRH5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347316.1">
        <property type="nucleotide sequence ID" value="XM_004347266.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRH5"/>
    <dbReference type="STRING" id="595528.A0A0D2WRH5"/>
    <dbReference type="InParanoid" id="A0A0D2WRH5"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="512"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="842"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="104425" checksum="EE293EAE235615A2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRM6</accession>
    <name>A0A0D2WRM6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346889.1">
        <property type="nucleotide sequence ID" value="XM_004346839.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRM6"/>
    <dbReference type="STRING" id="595528.A0A0D2WRM6"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRM6"/>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="568" mass="60699" checksum="14F767F771E04ADC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS14</accession>
    <name>A0A0D2WS14_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_004811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347562.1">
        <property type="nucleotide sequence ID" value="XM_004347512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS14"/>
    <dbReference type="STRING" id="595528.A0A0D2WS14"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS14"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS14"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266541" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="773"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="555"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE94123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1062" mass="111088" checksum="B3E907C56FE921F7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS95</accession>
    <name>A0A0D2WS95_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346189.1">
        <property type="nucleotide sequence ID" value="XM_004346139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS95"/>
    <dbReference type="InParanoid" id="A0A0D2WS95"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS95"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="33310" checksum="E3E7C26C2B8626A4" modified="2015-04-29" version="1">MEDDPLATLAELASTDPVAESLDLNPDSPPGNWPVRTVRSLERAMVKGALVERLKIATFGGELAVESLLNFVYQPRSQPLEPTFNENFLLLDLANSKVLPSALRSLRGRHPGIFIEDLVARPHDFIDTNRSIATLDLSGNSFADEDLPNVLKLVQLCQPSIVKLRSNRFGYGRCNPMIVAWLRKTVELPCVVFVDIVGEMFTGVDWAPAYEDWPATLWTKLVFIRLQWLEGHDWKLVHICPSNFTALAQETHRLYFLHKSANPMFTLLRLQEVLLLATPEWRAASNATAIASLQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSM4</accession>
    <name>A0A0D2WSM4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346376.1">
        <property type="nucleotide sequence ID" value="XM_004346326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSM4"/>
    <dbReference type="InParanoid" id="A0A0D2WSM4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="256" mass="27747" checksum="5A6299B8B60FF34D" modified="2015-04-29" version="1">MNKTYTSVTLQDKVSSTPVIAVATTYNDGGNKGLYNRFLDFNSIVTGQTTPPDYPPLVSLTASGSGLVAGENLKITIGGAGSAMGGVCRLYYKSLVLPAEKYHALAGALRAGYVKKVHFVASDVSTVNNTTAVLPYQVTGGLTQIQKYGALGINNVDAQLRSCNIDINDEQYFNKDMFLDLELWNQVRECMVGYGTSNEIGSLLNYHDWKNFIIRNGSTSVAYDKFMGNPDTRAGSLGDMNDIKRVRQNAEDALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTE7</accession>
    <name>A0A0D2WTE7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345727.1">
        <property type="nucleotide sequence ID" value="XM_004345677.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTE7"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTE7"/>
    <dbReference type="OMA" id="NTCHINC"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTE7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254786" evidence="11">
        <location>
            <begin position="25"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="838"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2286" mass="241453" checksum="97EE7435D886452E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTV6</accession>
    <name>A0A0D2WTV6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTV6"/>
    <dbReference type="STRING" id="595528.A0A0D2WTV6"/>
    <dbReference type="InParanoid" id="A0A0D2WTV6"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="82" mass="8957" checksum="F836D85E2A95065D" modified="2015-04-29" version="1">MSLDIRVKKADRIYHEGELVAGVVVVTSKGEMAHNGMTLALDGWVNLQLSSKSVGVFEAFYNSIKPIQLLSSSLEILRPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVU2</accession>
    <name>A0A0D2WVU2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344379.1">
        <property type="nucleotide sequence ID" value="XM_004344329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVU2"/>
    <dbReference type="STRING" id="595528.A0A0D2WVU2"/>
    <dbReference type="eggNOG" id="KOG2293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVU2"/>
    <dbReference type="OrthoDB" id="10262769at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22687">
        <property type="entry name" value="FHA_MCRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037912">
        <property type="entry name" value="MCRS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025999">
        <property type="entry name" value="MCRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233:SF0">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13325">
        <property type="entry name" value="MCRS_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="674"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="766" mass="78844" checksum="5228FDBA7E8BA46C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWL1</accession>
    <name>A0A0D2WWL1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWL1"/>
    <dbReference type="InParanoid" id="A0A0D2WWL1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254721" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26317" checksum="81C884C130B16070" modified="2015-04-29" version="1">MGFILCIGHPLLVIHCRSSLSCPSCQCVHTINNHVNVLSKRVSLLNLSGSGQGQITNFYPWLFPIFQPKARPVTIKLTRLTTPRVTRCISPEPSDVPMYPTTNGRTCGQTAMGSAVHHHLPFSPLSRPLSSPTRSCCCDEISLPTHLHLHLQARCVRVLLEQGSAYGAQTSKRHPFFFPLCLHLPSPSPTCSCYCTESDGCLVHTTLQARMRARSCGTSPVYIRRPNQKPASSFLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWW7</accession>
    <name>A0A0D2WWW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWW7"/>
    <dbReference type="STRING" id="595528.A0A0D2WWW7"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWW7"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266637" evidence="5">
        <location>
            <begin position="20"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="659" mass="72026" checksum="B58CCA7D128657E1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYC3</accession>
    <name>A0A0D2WYC3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346426">
        <property type="protein sequence ID" value="KJE98430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYC3"/>
    <dbReference type="InParanoid" id="A0A0D2WYC3"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="102" mass="12008" checksum="50D92FE2E754CA4E" modified="2015-04-29" version="1" fragment="single">MRTASFLRIQTCEREVAEKTKANPQSQRSSRERINDFRCLLLTLTSQTGNFPLKYTITPHNNKDIQHCLNNLSSKTQSRQDTKQKMKQKQARKQSQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYZ2</accession>
    <name>A0A0D2WYZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346402">
        <property type="protein sequence ID" value="KJE98368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYZ2"/>
    <dbReference type="InParanoid" id="A0A0D2WYZ2"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF78">
        <property type="entry name" value="OS12G0587133 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116115" checksum="7C0954250D7178B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WZ16</accession>
    <name>A0A0D2WZ16_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346425">
        <property type="protein sequence ID" value="KJE98428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WZ16"/>
    <dbReference type="InParanoid" id="A0A0D2WZ16"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="505" mass="53840" checksum="FF1ADC368A4747E0" modified="2015-04-29" version="1">MNPQPSSSSSQQQQQQDSDGVLNVLQSFRSKRRVDLPLRAITATLFVDGIACLIVDVTCFAFLWWRCGWQAAHAVLQSRLAETLLRSQSKASPSAAAARGGSLGASSSTAVTTPAAEKQRKVWPAQLQHHQQPHPHQQEQSKAPLHTHHPLPHQHSAAQLYHHQPTQLVRQPHSAADLTTHLSSALGDGYQNLLFDRISPTMFEDRYSAPTTDHDDGEAAPPLSSFQSRSTAPITAAAAAGAAGAAGAAGISEAMNISNRGSLPKNYSTAMFGTPPSYSAHYFISSPRSYEAASAMAAAAASGAIHQQQSPPGIGASTSRRASVVSSGSGTWLSSTPPFKHANPFKSMNHQSPPQPNHSQPHQHHSHHFESGDASRLGSSRAGSGALGEDTPSHLAASPARAIPMPRGRHQSVDPSLDDPHHSNGWLQSKRTSDVSDDDDLTVLMTQLQSAEALRVYSRLDASTQHSMSDMMAKFSDFKAAAANFDFPPNADQTTAPEQQPPGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D2</accession>
    <name>A0A0D2X0D2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365301.1">
        <property type="nucleotide sequence ID" value="XM_004365244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0D2"/>
    <dbReference type="FunCoup" id="A0A0D2X0D2">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0D2"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0D2"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0D2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="320"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="453" mass="51172" checksum="EC0919923CFACD91" modified="2015-04-29" version="1">MTAMDVPLSWLEDAARQVRGRQIAWDGHQRAGFITEEELDMIRRYDNKGAATQNELLATQGQKYGALFLHLLGKITADQTVQYLILLVDDLLSESRDRAKLFHACNTASDGVLPYAPFLSLLRSRDAYTRYASNKILSVLLSTGRPLDTRSVSFYAAWLSNELTSADESSLSVVLSALQAILSVEQIRNAFYSETKGVELLIDVIDRRRPNFQIQYQVVFCFWLLTFTPSIADTITIHPVVNTLSLILKGTTKEKVVRIILATLRNLLEKVKDSKHNAAQMIGAKVLEAVTLLQTKQYADEDMVEDIKFVLDELQKAVNELSSFDQYAGELRSGNLQWSPVHRSERFWLENAVRFNDNKFEMLRLLATVLQSSTDPTVLAVAAHDVGSYVRYVDGGKKTLESLGIKTAVMHLMAHRDDNVRYEALLAVQKLMVTNWEYLGRNVTTAKDRLPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0M6</accession>
    <name>A0A0D2X0M6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365691.1">
        <property type="nucleotide sequence ID" value="XM_004365634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0M6"/>
    <dbReference type="STRING" id="595528.A0A0D2X0M6"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0M6"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="732"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="909"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126791" checksum="D1E4DC60A9FB2917" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q0</accession>
    <name>A0A0D2X1Q0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-beta-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349109.1">
        <property type="nucleotide sequence ID" value="XM_004349059.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q0"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Q0"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Q0"/>
    <dbReference type="OMA" id="FYPEQPE"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Q0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270336" evidence="3">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="109"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="49678" checksum="36874FDD5CFBF1D3" modified="2015-04-29" version="1">MLSLTVAVAILVGAVLAWLGVQHRTRTIASRPRPPVTLAVLPRSVDAAGGPVDAREKAFLDGFASAGAEIVQVTPLLSTTSKSSTASRSTSTSTSTTGTAATTQCKRILITGGRGFVAAYVIRRYLKQQQQSSSENGLLHVHVLDLQLPDPTSTATDAIGQAVYQPSITYIRADITNKEQMKIATRGMDVVLHMASLLPSVGVSRDTFERVNVRGVETVLAACRENGVKALVYTSSATVLLDLHNKSIENADEDHPYPRQHIDDYTATKAAAERIVLKANTPSFATCILRPSAVFGLGDKVLLDMLVRGQTPVYLGKGNELLDYVHGDSVAQGHVLASERLAPGSKAAGQIYHICTGKPVMYRKFNGDGTGDKTLSHWGYKHPSSLPLPIATTMARLNEFVHSVTGSAPFGLALSLTAIDYTQRTYWFSVEKARRDLGYDPLDSLEALVSDVKTFQKTMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1V3</accession>
    <name>A0A0D2X1V3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349340.1">
        <property type="nucleotide sequence ID" value="XM_004349290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1V3"/>
    <dbReference type="eggNOG" id="KOG3744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1V3"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1V3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="469" mass="49969" checksum="2F624EC23D593877" modified="2015-04-29" version="1">MILRPRSSRASVLSAAAAAAAGAVIALGLLLSLAAVRCSATTDNADRHSHGSHLRQPLALHAARSEEASSSLLLDGGAAEHPSSATRSDEPAVRNLADSSGSGASSFTGPDDDVRALMTLAADASDGALAGPVYEGLPVPDYSTTYLPCPGAYCGRVLAVVPANGSVGAHVRLATGECGACPDGYRSDGYVCLPCSEPIPAYAWMYLIGMALAYYYPATAVVLVNWANVRVRQHLISATLETVLAILFAVLVNTPAWTLDLTGCAVSSVDDFYSMLHNPEIDFEYVLQCGQQAVYPLFSIVLEIFGFQFALLLLFRVPLVWLQPKSQFDRDVLLMSFFLLPLAALAFVLFCGPLYYAFPYLGIVFSLLSTTGALSGAFGQRSVVAARMQQVPLLKMIREIILLPHTLLLLTRQAGVMGFSVAALICFYDGFEPGTSADILAPHVISVLLTPLVPSLLFFATERVTRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1V5</accession>
    <name>A0A0D2X1V5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349350.1">
        <property type="nucleotide sequence ID" value="XM_004349300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1V5"/>
    <dbReference type="FunCoup" id="A0A0D2X1V5">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1V5"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1V5"/>
    <dbReference type="OMA" id="KISMHIS"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1V5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="195"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="366" mass="40491" checksum="AB34E97A117AABC6" modified="2015-04-29" version="1">MSFVACSLRLSVVRQQASLVASALSRQHGASISTNAHGWSVERSSCVGAVQARLSSSLASSSVQPTPEAPSPSTAWQTIRSAISDMKDGAVQLYRDVGQMRKLTSQSRKLNWAETQFVDITRTNLKSLVPFAILTLLPGSFVIIPLAVSLHPTIVPTVFQPRKMKLEQRVANALRREHTAEDVLQQLKAACWNQVAFETQPDSVHDALKLFYGLRLNRDLSDHSKLPTLEQVTSTAYLEEYAELRDEFQRAAHCGRLTTSQCKTVAEFDGVRTYPLFSLRSRLNARAEAIHNDDILLAEYGVQNITRVQLIAACEARGIPTLDVSEADLRQMLNAWLQLSAAETKPRQPLYHACYAALLTVIALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X227</accession>
    <name>A0A0D2X227_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363748.1">
        <property type="nucleotide sequence ID" value="XM_004363691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X227"/>
    <dbReference type="STRING" id="595528.A0A0D2X227"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X227"/>
    <dbReference type="OMA" id="NDIFKPH"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X227"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="859"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="212"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="941" mass="101854" checksum="107405A932BF2622" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X259</accession>
    <name>A0A0D2X259_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLA2c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X259"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X259"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="5">
        <location>
            <begin position="403"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="5">
        <location>
            <begin position="835"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1537" mass="167565" checksum="4386F292A05A958A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X281</accession>
    <name>A0A0D2X281_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363961.1">
        <property type="nucleotide sequence ID" value="XM_004363904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X281"/>
    <dbReference type="InParanoid" id="A0A0D2X281"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270348" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34407" checksum="61F79FF82661988E" modified="2015-04-29" version="1">MIGQRMLAASLLVLAIATHHALAANFVFGPNTKVVADVWDAENQLILQPSGRLIVTGGDNIYEIVRSGSTYTKIPLMSGPGYYLGLSQVNNTLYALQSVPGCSTNESATTNFLLSAPIVDGKQLVFSKIYAIQSFTLPNGMAFYDNKFYIADTAYTGSGKIATLALSPSDPNVITAQVTFLTTAQAEAPNGVKIFNNTLYYSSLGTVKSVLLTQSPPKPVALFTLDTVLDDMNLLNVVGYPNTLLMVCNYLEGEIVLWDLTESKQVYKTRLEGFSGPSSLQMTGGALGFPLDSVLLTDKGVVCSHTATGNFLSYFTIVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X283</accession>
    <name>A0A0D2X283_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X283"/>
    <dbReference type="InParanoid" id="A0A0D2X283"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="869" mass="90409" checksum="8AC1D18CE16BE862" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X369</accession>
    <name>A0A0D2X369_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphorylase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347280.2">
        <property type="nucleotide sequence ID" value="XM_004347230.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X369"/>
    <dbReference type="eggNOG" id="KOG3635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X369"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X369"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH15-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="7">
        <location>
            <begin position="184"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1424" mass="155987" checksum="3B1B64B43E6A949D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3F1</accession>
    <name>A0A0D2X3F1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3F1"/>
    <dbReference type="FunCoup" id="A0A0D2X3F1">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3F1"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3F1"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="10047020at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3F1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="747" mass="85817" checksum="74BA9D7E3E354B2B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3W4</accession>
    <name>A0A0D2X3W4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Centaurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3W4"/>
    <dbReference type="STRING" id="595528.A0A0D2X3W4"/>
    <dbReference type="InParanoid" id="A0A0D2X3W4"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3W4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="325"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="590"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="870"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="904" mass="98480" checksum="609DCB53F33EBA30" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Z5</accession>
    <name>A0A0D2X3Z5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346321.2">
        <property type="nucleotide sequence ID" value="XM_004346271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Z5"/>
    <dbReference type="InParanoid" id="A0A0D2X3Z5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="367" mass="42800" checksum="1F4ED998EACFBEFB" modified="2015-04-29" version="1">MPLSLVMFCASHVSDEARLDMMEQMLNSWAAQFLPVELWISVSCANDALKDKVKTLLTNRGPGLNAFIRRSPYKQFEHLQWLTSKYIERFSGRSHADAWVCFTDDDDTFAIHRTSVFGQLIRAPENDQHADDAVPFVCINGPPLNAPLPRSPEQTLLIKAQNVHGNKLVKRGSGQEYFQYCVRLSLLEYFFKHTTEVLWQYQFADLLFQRFLLRGVHIDKPDNWWPLQADEDASCEYVYWDRHALDQARNPNPNDEGWIPLMDYLRLSMASSVDFNREDYWRWLKGSYKVTWAAGKLSRDNLKLKAQLELPIVQEMIRLPSYVHWRIQDLQERGQPEKALRLQKQLDAFVAKANNTPVAFQQGERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X414</accession>
    <name>A0A0D2X414_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346407.1">
        <property type="nucleotide sequence ID" value="XM_004346357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X414"/>
    <dbReference type="STRING" id="595528.A0A0D2X414"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X414"/>
    <dbReference type="OrthoDB" id="413581at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X414"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266799" description="Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="4">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1152" mass="118666" checksum="D6E64611DD06027D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X432</accession>
    <name>A0A0D2X432_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345399.2">
        <property type="nucleotide sequence ID" value="XM_004345349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X432"/>
    <dbReference type="STRING" id="595528.A0A0D2X432"/>
    <dbReference type="eggNOG" id="KOG1171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X432"/>
    <dbReference type="OrthoDB" id="6283463at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="136"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="53123" checksum="63404E8576AA3F6A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X456</accession>
    <name>A0A0D2X456_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345513.2">
        <property type="nucleotide sequence ID" value="XM_004345463.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X456"/>
    <dbReference type="InParanoid" id="A0A0D2X456"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="22903" checksum="EAEB39B17336D1BC" modified="2015-04-29" version="1">MNHWARQSGPGVAGNDATQPIADDLISDDALKRGANIFLRPEELKIVNFVVRDASTLARPDVVELFTRISQVPQHLHRTTFEKLLRSLPLTLSSSCHSKELANLNPNVTPVDLARTRKRRHAGDSDDDDTSAFEEALIGGSDTNVTFSLRPEILEQSVAISRTNTLGVSSRLTSGVVAMQLVPNDENGNSTPKADRRKRHPLTDCSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4B8</accession>
    <name>A0A0D2X4B8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4B8"/>
    <dbReference type="STRING" id="595528.A0A0D2X4B8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4B8"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="647"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="677"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="715"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="761" mass="84028" checksum="2C02D9E5AC2D77AB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4F7</accession>
    <name>A0A0D2X4F7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA-dependent ATP-dependent helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4F7"/>
    <dbReference type="FunCoup" id="A0A0D2X4F7">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4F7"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4F7"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4F7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000001">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000005">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ku" evidence="14">
        <location>
            <begin position="280"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE95979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="731" mass="81355" checksum="674CB242FA33A745" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4J7</accession>
    <name>A0A0D2X4J7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270667.1">
        <property type="nucleotide sequence ID" value="XM_011272365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4J7"/>
    <dbReference type="FunCoup" id="A0A0D2X4J7">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4J7"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4J7"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4J7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="509" mass="56478" checksum="85D08517EA5666F6" modified="2015-04-29" version="1">MNSMELQSALASSSFVAIVEQERLQSQAAILVATLALLVRAAVGLYPHSGQATPPMYGDYEAQRHWMEITLHLPPAEWYHNSTSNDLLYWGLDYPPLTAYGSWLCGAIAHFFDPEWVALDTSRGFESKSSKAFMRATVLVSDLLIFFPAVFLFCRQILADFTRSKQIAIAFMILLQPGLILIDHGHFQYNCISLGLALLAIVAVMRDWDILGSVLFCLSLNYKQMSLYYAPAFFSFLLGKSLQSAHPVLRIAALGVTVIATFALCWLPFLTSIDSVAQVLHRIFPIGRGLFEDKVANVWCAVSVLIKLRAIFEQALLVRISAICTLLAILPSSVNLALRPSQTGFLYALVNSSLGFFLFSYQVHEKSILLVALPASLLLASDPLNAVFFLLLSTASMFPLLHKDGLAIPYAICIVFFVIVVLHMLNVSLQACQHLTTIGKLQLAAVIVCFSGLHLAWYFYIPPAHLPHANLLLFAVVSCASFVLFAVYFNWRQWQLNGVPTSTHKLKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4S7</accession>
    <name>A0A0D2X4S7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344503.2">
        <property type="nucleotide sequence ID" value="XM_004344453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4S7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4S7"/>
    <dbReference type="eggNOG" id="KOG1452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4S7"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4S7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="181"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="711"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="81898" checksum="8B6CA659F8D0AFD0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X532</accession>
    <name>A0A0D2X532_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X532"/>
    <dbReference type="STRING" id="595528.A0A0D2X532"/>
    <dbReference type="eggNOG" id="ENOG502S2G1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X532"/>
    <dbReference type="OMA" id="MWFLQAY"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X532"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="107"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="245" mass="25965" checksum="F8BEF3B12C75FCC7" modified="2015-04-29" version="1">MAADDSVARRRISPAARIPLAIRSASGTAAIESKHSTKKACCHSESVPQQSAQSAHSAQPVPPMQPHLNPSHSHAPSLSSSGVASTTTTTTTTSSMLTTSFWSHVPSWRTAALNTSRCLVFCSLGDLSALFYMQSQHIESSPLVMAVSMAAGLLTSFGAETILLKRNQSVSSWSQAANLAAGMSLISMLVMEAAMNIVDVHLTGGHVHLDRPEWWLSVAVALGAGFVAPLPYTYARLRKLGKSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5C8</accession>
    <name>A0A0D2X5C8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343276.1">
        <property type="nucleotide sequence ID" value="XM_004343226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5C8"/>
    <dbReference type="FunCoup" id="A0A0D2X5C8">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5C8"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5C8"/>
    <dbReference type="OMA" id="FRKTCAD"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5C8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="688" mass="75094" checksum="DF75D07559C3AEA4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5G5</accession>
    <name>A0A0D2X5G5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342957.1">
        <property type="nucleotide sequence ID" value="XM_004342907.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5G5"/>
    <dbReference type="FunCoup" id="A0A0D2X5G5">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5G5"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5G5"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5G5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="34425" checksum="5F6C533DBB773233" modified="2015-04-29" version="1">MFGSLRGRKKLVDDEHETNVKNYMRLQEVSENLQKSLKSFQDSMKAITQSHNRMAACVDEMFEPFEAQEVKQSAKLYAEACQALERTNHDLESEMRITLFEPMTLFMKIFPIVDELLKKRDQKLIELEKRREKLGKNSKSKDRGSSRAEQAERAVAEAEREYNELNDKLRAGLPGFCEARTSYFDACFEALVKIQLQCSKNCQQLVAGKMGGGFSKTQALSDAAYDQDIRAKLDSFLSLAIVSGSSKMPRSALGASSIASSQAAAALPASPVSAPIPAATAVASAADEMDEQAPAQDYVDEQASQPEAASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5H5</accession>
    <name>A0A0D2X5H5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270847.1">
        <property type="nucleotide sequence ID" value="XM_011272545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5H5"/>
    <dbReference type="eggNOG" id="KOG0632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5H5"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5H5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF2">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266834" description="glutathione gamma-glutamylcysteinyltransferase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C83" evidence="7">
        <location>
            <begin position="216"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="56005" checksum="1FE94ACC81572064" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5I3</accession>
    <name>A0A0D2X5I3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343029.1">
        <property type="nucleotide sequence ID" value="XM_004342979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5I3"/>
    <dbReference type="FunCoup" id="A0A0D2X5I3">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5I3"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5I3"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5I3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="414" mass="45131" checksum="BA7A04DE4EA3C870" modified="2015-04-29" version="1">MSGRKRTTSTSSGGAMDTSSLAPTGSKSSSKPRAGASAAATTQASMSPAHLGSVEDRRDAGKRAMQEIRSRVVLEADRVENAASIDFPANFPEEAAELAWDFGKFAAGFRIERIETDPDDPMAVTFDMVGVDAAIANAFRRILIAEVPTMAIETVFFTNNTSIIHDEALAHRLGLVPIRADPRYFETRDTPDTQATDRNTLVFTLDVKCTKNPHASPNATDDTEKYINSRVLSSDIVWVPKGDQEAQFQDAPIAPVHDDILIAKLRPGQAVACEMHCIKSIGRDHAKFSPVGTASYRLLPEIILTRPVTGDDAYLLQKCFSPGTIGVRNENGVPTAYVIDARRDTCSREIFRHERLASAVKMRRVRDHFLFSIESTGALPPGDLLFESVLKLKSKCELILAHLNNATSSVDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZK1</accession>
    <name>A0A0D2TZK1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">arginine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_009259</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZK1"/>
    <dbReference type="STRING" id="595528.A0A0D2TZK1"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZK1"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000116">
        <property type="entry name" value="Arginine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="405"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="16">
        <location>
            <begin position="1124"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="669"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1050"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1240" mass="132732" checksum="4D08567E4B81120C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U047</accession>
    <name>A0A0D2U047_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365063.1">
        <property type="nucleotide sequence ID" value="XM_004365006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U047"/>
    <dbReference type="STRING" id="595528.A0A0D2U047"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U047"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U047"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="432" mass="46264" checksum="8E11F66930E46693" modified="2015-04-29" version="1">MAANIALRGVRVLDLSRVLAAPFCTMLLGDMGADVIKIESPNGGDDTRKWGPPFAAPAVKRDNHQVPVRQPESAQHTSAVGQADASAPAAESAYFLAANRNKRSVTVNLKSERGVQIVRELAATADVLVENFLPGKMEQLGLGYEGVLQPLNPRLVYCSLTGFGRHGPYRDRAGYDLVTQAMGGLMHITGQPGSGPVKVGVAITDLATGLFAHGAILTALLARTHTNRGQRVDCSLMSSTVALLANIGSNYLIAGKEAKRLGNAHPSIVPYQSFQSSDGEFVVAVGNDAQFVAFCRVLGLPDLPRDSRFAKNADRVAHREVLIPLIAAMLRTQPTAHWMDALTREDLPCGPINNLQQVFNDPHVLATGLIQQVEHPTVGRISLTGSPVQYSDTPARIALPPPTLGQHTDQILAEVLGYTPEQIAALRRDKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1X9</accession>
    <name>A0A0D2U1X9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1X9"/>
    <dbReference type="InParanoid" id="A0A0D2U1X9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="128" mass="13983" checksum="632D9B976CDBBE67" modified="2015-04-29" version="1">MRLCQKLMAALSNETESAFVRGRRAWAQVAGGERTQKSTAFTYAVTVFHVATKRMLILTEPASLTEPPSHPHKGAHNTQDSGLILCFGAQPDGCSDSTDEKNIRNRALASPCLGSWSKRAKENNDHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2R6</accession>
    <name>A0A0D2U2R6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365814.1">
        <property type="nucleotide sequence ID" value="XM_004365757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2R6"/>
    <dbReference type="FunCoup" id="A0A0D2U2R6">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U2R6"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2R6"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2R6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="142" mass="15826" checksum="E63E35A8C4EA6EDE" modified="2015-04-29" version="1">MSAAAASTPVAASAAAPKVKTVAPKRIGKVQKKKPQRFIVDCSHPVEDAIIKIAELEKFFHDRIKVEGKINNLGRHIAITTDASKVTVTANDIPLSKRYLKYLTNKFLKKSQLRDYLHVVSTSPTTYELRYFKIAADEEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4H0</accession>
    <name>A0A0D2U4H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349947.1">
        <property type="nucleotide sequence ID" value="XM_004349897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4H0"/>
    <dbReference type="InParanoid" id="A0A0D2U4H0"/>
    <dbReference type="OrthoDB" id="6161911at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10861" checksum="61337B1D743BAD02" modified="2015-04-29" version="1">MLVKISTLRAFSSLVSSRAAAAAATTTATATATSKPGYDHARGPFQSSKARDGQSIYSYDNKGDAYQTQLFFQYTPYSYFDVERDVGPHRIPQPVPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U608</accession>
    <name>A0A0D2U608_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U608"/>
    <dbReference type="InParanoid" id="A0A0D2U608"/>
    <dbReference type="OrthoDB" id="549068at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U608"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042023">
        <property type="term" value="P:DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033246">
        <property type="entry name" value="BIN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="15906" checksum="1C289328F35ADF21" modified="2015-04-29" version="1">MDIDLSTNADTNAAADADAADATFDLAAAAAEAVEGLLQSKAKATAALPVGAIPLVLGKPATAFLMETTEPQLNLSGDTGSVGRLVVNAQDAAAPLVLDLKGLIFQGTVVPSNTFMLVTIGPNEARIDATVNNVIHTTCLGDALDSMTVVEGSIDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7R3</accession>
    <name>A0A0D2U7R3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349055.1">
        <property type="nucleotide sequence ID" value="XM_004349005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7R3"/>
    <dbReference type="STRING" id="595528.A0A0D2U7R3"/>
    <dbReference type="InParanoid" id="A0A0D2U7R3"/>
    <dbReference type="OMA" id="NANECNQ"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7R3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF9">
        <property type="entry name" value="PROTEIN SPINDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="284"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="467"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="652" mass="72432" checksum="05EB57E0F6B2E531" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDN6</accession>
    <name>A0A0D2UDN6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347805.1">
        <property type="nucleotide sequence ID" value="XM_004347755.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDN6"/>
    <dbReference type="InParanoid" id="A0A0D2UDN6"/>
    <dbReference type="OrthoDB" id="5946061at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032055">
        <property type="entry name" value="TMEM72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16054">
        <property type="entry name" value="TMEM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="156" mass="17234" checksum="3BA483CC5FD28031" modified="2015-04-29" version="1">MPSQDSNFFWRHIGICARIFGLLTVVALWGTGIAEVGDHLGVGAYTICAGIVMTIIEGSWVLQKCACCNAESCIYKTYFFLVNLRGWIKFILYALMSIVCFIETTWCIVGGVMLDVDAVFYLLSSFVSKKEGDAAAKDESKPEEKRASLRDPNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE81</accession>
    <name>A0A0D2UE81_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE81"/>
    <dbReference type="STRING" id="595528.A0A0D2UE81"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UE81"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UE81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="229"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="488" mass="51565" checksum="3FF7424FD7D6655F" modified="2015-04-29" version="1">MAQPPPVQPQPASPSTHPNELSTTTQGSLSALHQSQSQSQAHSESPAPSSSASSSTHHRSLSTGSSSISFLSSSIANLITSSATAITKTIAKHRRSPSAADSSTSASPSPSFTASDNHASSNIGATSRSAGSPNISSDSNTVLHDAKASAGAAAAAAIPFDSNTAASAGLPSATRPLSSQYEDGGAPPAAMARVSPPLNAAAALPAPAAPAPAAAPLLLVKPSSSGPARTLFQGTLHKWTNYITNWQSRFVVITGEPEWTLSYYMNENQQADGAAVRSFLPLGDVVITVAADSDTDFSVYNKSEAYYLRAPSKEERKQWVVALGSAKSQQAMALARLAESTEIDERNRRTEQLNRLIAASRHHEEAIRKQLVNVQTAVSTLVLEAKEAENGTGAGSGAVVVVPAVADKRKSTRELLVERAMVLRATLRTTMDNLAESIDLVNEQEEIWERSVEYERRQQLKAEQSLRAIRSQQEALEKLLERAQAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEB8</accession>
    <name>A0A0D2UEB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lysophosphatidylcholine acyltransferase 2-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_004258</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEB8"/>
    <dbReference type="STRING" id="595528.A0A0D2UEB8"/>
    <dbReference type="eggNOG" id="KOG4666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEB8"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEB8"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE93471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="639" mass="69980" checksum="99B354A86592E75B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFJ5</accession>
    <name>A0A0D2UFJ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the costars family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347370.1">
        <property type="nucleotide sequence ID" value="XM_004347320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFJ5"/>
    <dbReference type="eggNOG" id="KOG3376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFJ5"/>
    <dbReference type="OMA" id="QRVHDNV"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFJ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1540:FF:000002">
        <property type="entry name" value="costars family protein ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044302">
        <property type="entry name" value="Costars"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334:SF1">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="81" mass="9101" checksum="4BEC27196E8925C1" modified="2015-04-29" version="1">MNVDHEIGLLKEEIKRLGAKNASGQYSVKYGVLFKDDRVANIFEALLGTLKSAKKRKIVDFKGEMLLQGVHDDVDVILLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHX9</accession>
    <name>A0A0D2UHX9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346995.2">
        <property type="nucleotide sequence ID" value="XM_004346945.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHX9"/>
    <dbReference type="eggNOG" id="ENOG502QSNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHX9"/>
    <dbReference type="OrthoDB" id="2125500at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268556" description="Glycosyltransferase 2-like domain-containing protein" evidence="3">
        <location>
            <begin position="37"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1805" mass="199616" checksum="1CC8E6949749E17A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIZ2</accession>
    <name>A0A0D2UIZ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346251.1">
        <property type="nucleotide sequence ID" value="XM_004346201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIZ2"/>
    <dbReference type="InParanoid" id="A0A0D2UIZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="374" mass="41053" checksum="5BD7919726AD84DC" modified="2015-04-29" version="1">MNQTIEQFNRRAARNAARNNAIPRRVAQNIPYCSLNVGDAPVTTEWVQGLFDAVLNGIRFIIFFVHLNRIQKQNVRGGNIYIISRSTIERFPIGGHWGKSFMLKNGWQKYKSSDERFVKYLIHQGGLSLLWVRDIQAVRNAGLEEQLEDEQELMAAQAVGNAGLEEQPEDDQELMAAVGNAGLEEQPYDEQELMAAQAVGLEEQPEVEQELMAAFGNAGLEEQPEDEQDAFGNAGLEEHPEVEQELMAAFGNAGLAEQPDDVNGAIDEHELMAVMADLLPLPEGEWLGGRLLSDMLDVEPFLNSDPNAAHYGQGTVAPTTLASAPADTVAAYLDAYLQEGSPAGAYIMSRSPPQVNTRSPADEPEADAKMPFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJE6</accession>
    <name>A0A0D2UJE6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJE6"/>
    <dbReference type="InParanoid" id="A0A0D2UJE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="138" mass="16091" checksum="7F87AAFD3E31D74B" modified="2015-04-29" version="1">MELCLKVGQFQKKKKKKKRAKPIDLNPFQKGAEGRGFQLTTEQRPVGGRKLRGKWRDSESARGKHKTRKKARKKRKSKKIVRNKTTRKAERQRHTRKEDPCCTAYGESVRRNVALCKCGFPTKSEQRKTKVTKNLPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL52</accession>
    <name>A0A0D2UL52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL52"/>
    <dbReference type="STRING" id="595528.A0A0D2UL52"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UL52"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UL52"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253554" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="6">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="380" mass="38515" checksum="A92BFB6E4A9259A6" modified="2015-04-29" version="1">MTPKGFAFGLLLLLLCVNYHVQMAQAANACDIGGVCTCSGTQVRCDDRSLTFIPSGIPNDTTILSLNGNQITNISAHTFTGLTALTFLHLGANQITSIPVGAFTGLTVLRALFLSDNQITSIPADAFTGLTALVSLYLYNNQITSIPSAAFKDLSVVGVLALNNNPFTTLPPGLFQGLPNGLWLSCDEYSCVGPLRPNNFAFGANTAAPPSTYGSASTPNQCDTACATCYGYGSSSCCELNCLTCSSSDLCTQCYEGFVLMDGSCVSLASAASASIASIASQASASAASASSVWLTSAASVASAASASAASAASAASNESSGASSGPIIGGVIGGVFALLLLVALVVALRRRRALVSSPTTYATLDEGPSGMSMTSKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULK7</accession>
    <name>A0A0D2ULK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULK7"/>
    <dbReference type="InParanoid" id="A0A0D2ULK7"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="299" mass="32669" checksum="DC6859803A45A19A" modified="2015-04-29" version="1">MAEPSHLTDPLWPDVDPKAEKSAQFVLQDHQHLHRLCMDSLPSPFKLMESDYVETSPGSGVLQHYANGSSKAVGFSVVVPHPTNDRVSPFWRLTRKASYCFVAQEQQFAQTKLGFSRSLDENWLAGGMVHYVVHPTVADMTIAEFQAELLTLFSTQCGVGMGSDSGLSTSALSIGGSSTVSGKTIEDAPSSIRPIVAALRRHVSQCAGVDPTRALVSCMVHDNLALRQLSLDDAMQHEDLCWYLYCAILQTTFSLGGLQFRDQVNTFLADCALEFGFPSAEVKTDEPSHPASSEPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP02</accession>
    <name>A0A0D2UP02_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343699.1">
        <property type="nucleotide sequence ID" value="XM_004343649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UP02"/>
    <dbReference type="FunCoup" id="A0A0D2UP02">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP02"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP02"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP02"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="8">
        <location>
            <begin position="343"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="499" mass="53966" checksum="2550A9E7EFA8A087" modified="2015-04-29" version="1">MLSLPRGFSVLAVRSASASIASASIASAAASASASAAASASIRAISTATVTARRAVAASQSQSQSASVVARSSLTVSAVRPFSSSLGRAAYSKDAKDAKDAKDAGKDGKNGKDSKDAGKDGKDGKEKKKEVSLPPGTTSDLSRNLSNRLKEGFDDKEYKQNVEEFQAGMRPIMEPMEPIGKAAQQAKSIAVATAQSVPVQAVVGGIKATANVAGKVANAVVDQIPTDHPIVQGLTDTASFVKREIIDTAHNSTRPYRPPAKVKVLTPEEEEAAAAQADPTKTAVVVHQGFRWQKEWKNFKDSNPIMVKLQAARQRFGESDNAIIRVLSNVSDSISNIFSPSEIGMVIGEINRVDPNFNVDEFTIDCEKQIIPILMEAVFKSDLKALEQWCHEVCFRRLLEPIKSRRALGVQLEHKVMELNGVELRTAQLMEQGPTLVFIFNMQYTRVLRNSSSEIIEGDPDQILAATYAMALTRDLNVYDTHASWRVIDLGLVHERKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPB5</accession>
    <name>A0A0D2UPB5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343836.1">
        <property type="nucleotide sequence ID" value="XM_004343786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPB5"/>
    <dbReference type="FunCoup" id="A0A0D2UPB5">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPB5"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPB5"/>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPB5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="7">
        <location>
            <begin position="173"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="969" mass="110908" checksum="9D3FC0AFE7A2A8A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR80</accession>
    <name>A0A0D2UR80_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007353</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343212.1">
        <property type="nucleotide sequence ID" value="XM_004343162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR80"/>
    <dbReference type="STRING" id="595528.A0A0D2UR80"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UR80"/>
    <dbReference type="OMA" id="RLCEAYS"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UR80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="180"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="441" mass="48621" checksum="63EF4FDDC76665E0" modified="2015-04-29" version="1">MSVLRWRSLAAPPAELRIDVTLACGQSFRWKKTGDNEWSSVLGGRLISLQQTADDVLFADRTVSEPASAAATSMSMDSHDNGATDAAGAAAAGASSATKASVLLQSSIAPTMTNSTDVKPMLDDTLGDMLRRYFWLDVKLEPLYASWAASDPRFKYISQRLPGVRILRQDPTENLFSFICSSNNNISRITLMIDRMCQQYGVKRGDIDGQSFFDFPEVSALAQDGVEERLRELGFGYRAKFIEQAAKQVLKLGGSEWLLQQRALPYVTARTNLVQLQGVGPKVADCICLMSMDKHDAIPVDVHVRRLAERDYKLKLAVGESKTMTAAAHDQVGNFFRKLWGEYAGWAHSVMFSGELKRFEDRVAGEPSASAETDTKPRKANNSRKVEEGVTVKLESKPDILNAPLPRSKRAADKEMAESASQSAPPPVRHAAKKARMQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URJ3</accession>
    <name>A0A0D2URJ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343280.1">
        <property type="nucleotide sequence ID" value="XM_004343230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URJ3"/>
    <dbReference type="InParanoid" id="A0A0D2URJ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="446" mass="48671" checksum="1E2DFF93EF4E0C5B" modified="2015-04-29" version="1">MSPGVTGTASSPTGEVSRLCRELVSTNHTSEVAPSGRLPTTCSLAASIYSTATETSALAALSLTSPVASDDLKAGLTVLSTALNSPNLDSVSMFKLELLLLEQFLLYRQVLLCGPLNVETSTQYRQSLARLVAALPRRSPDENEDETQAKTKHPSLSDDGWKWNPFPQATTLVMLLEEELALRSAANSVQDLTELLELLGATFEIGPPRSRAELSDAAIKTLTEMYLHMAFAGDKIGRSVGRALAHWVYNNESGKGKLRQTLFEHDNEKRTFLEHLGRLEMSAETAPSCALLVQNWVCGDEELQREIVDSLFFTHPCQFFSSTCHKPLLSLNSALMSSARRLCVMVREVHPGRHATTSVLAGLAASVAELFVRCLREMPLQLVCAQLLLELKSHVKLSPGAESEAITMIASFPKSKLAETLRPLVNANIRPMPPPAGSKIDMAWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US65</accession>
    <name>A0A0D2US65_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342985.1">
        <property type="nucleotide sequence ID" value="XM_004342935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US65"/>
    <dbReference type="InParanoid" id="A0A0D2US65"/>
    <dbReference type="OrthoDB" id="2154664at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="44432" checksum="14FB76C806FBA0BA" modified="2015-04-29" version="1">MSNAKRVFGCLLVFAVIGSFTLYSTNTESDARQQAPLETADPQRMARTEQTEPLPSRFIARPDLTFSQVNAHKLMEDNAWVSPSVVRLQDGPDGWPRPWTAVAFSGTMRSFKYPALLDSLRNNLLAALGGTILIFSNSRLEDWPRSGLGCANSQEDLFDALRDLLPGKAEHFVVWRSFQVPDPMWTHNCASRPSLIQSLSVLDSYSLVLDYENQVGVKFDWIVRARPDVGFPEPLPSLASLNESVFVPGNSEYQLSNQFALVPRKYSDVFFQLPPREIECAVENDNDRLRLWLDTNNTPYYRHKAIHFTIVRAYYGAECFRSCNGFGVGSQCELRKVCEAMFGEITNDRKSKKVDAQLLISELKTPHAGCSVSLSSPAPVHLKERKFRSRTKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USI9</accession>
    <name>A0A0D2USI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270866.1">
        <property type="nucleotide sequence ID" value="XM_011272564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USI9"/>
    <dbReference type="STRING" id="595528.A0A0D2USI9"/>
    <dbReference type="eggNOG" id="KOG1865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2USI9"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2USI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="225"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="767"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1096" mass="119174" checksum="30569417158B01F4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTD3</accession>
    <name>A0A0D2UTD3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="12"/>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342489.2">
        <property type="nucleotide sequence ID" value="XM_004342440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTD3"/>
    <dbReference type="FunCoup" id="A0A0D2UTD3">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UTD3"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTD3"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTD3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="377"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE98241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="489" mass="53099" checksum="004CF41B6238531B" modified="2015-04-29" version="1">MLRLIASPASRSALANARGIATAAPALNAAAAAATAATAKPPRTYGNLKDSDRIFTNLYGRHDWGIKGALARGDWYKTKEILLKGHDWILNEVKKSGLRGRGGAGFPSGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLIAGRAMGARAAYIYIRGEFYNEASNMQVAIHEAYKAGFLGKNACGSGYDFDVFMHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVAPTICRRTGEWFASFGRERNQGTKLFCISGQVNTPVTVEEEMSIPLKELIERHAGGVIGGWDNLLAIIPGGASVPLLPRKICDDVLMDFDALRDVTSGLGTAAVIVMNKQSDVIRCISRLSDFYKHESCGQCTPCREGVGWLAKIMKRFVDGNAKPAEIDMIEELTRQIEGHTICALGDAAAWPVQGLIRHFRPEIESRIATFQQQKQEAKQRHAAEKAAKLQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGA1</accession>
    <name>A0A0D2VGA1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365349.2">
        <property type="nucleotide sequence ID" value="XM_004365292.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGA1"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGA1"/>
    <dbReference type="OrthoDB" id="17009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056883">
        <property type="entry name" value="NPHP3_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF24">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN DDB_G0287407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24884">
        <property type="entry name" value="NPHP3_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="216"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4062" evidence="8">
        <location>
            <begin position="422"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="670"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3 helical" evidence="9">
        <location>
            <begin position="868"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1524"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1646" mass="180494" checksum="1B0A42F4A9953288" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHQ6</accession>
    <name>A0A0D2VHQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHQ6"/>
    <dbReference type="InParanoid" id="A0A0D2VHQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="11419" checksum="EA105BC422708A64" modified="2015-04-29" version="1">MFILNVHGTSLRRLSFARSNEHSSQGCEASLKTPAHQDQTNVRPSFLWSIWGSTSASYSPGKPVETQHKLPLRWAGLRSSSPSAGRQAAEQNPERQLRGVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI15</accession>
    <name>A0A0D2VI15_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365886.2">
        <property type="nucleotide sequence ID" value="XM_004365829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI15"/>
    <dbReference type="SMR" id="A0A0D2VI15"/>
    <dbReference type="FunCoup" id="A0A0D2VI15">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI15"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI15"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="92"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="485" mass="52380" checksum="297F3455999B3A89" modified="2015-04-29" version="1">MTTLFAAATVAVRSSGLSLSSLSLSSLSVLPRLSSSSSSSKISPFASMSTSPSNPASAAPPPLVFSPAQRVSGFGDSVFAEFTALAIAHSAVNLGQGFPDFAAPDFVKQAGAKHIVESNLNQYVRSMGHVKLVNTLARHYAPADRHNNPSINPMTDIVVTAGATEGMFATFQAILNPGDEVILMEPFYDAYPAQITMAGGVPRYVPLRLKAAEARNGTSDDWYLDLAEFRAAFTSKTKAIVLNNPHNPLGKVFRRDELEAIAQVVCEKNVIAISDEVYEHLVFNDAPNRHIPLSTLPGMLERTIKLGSAGKTFSVTGWKVGWVVAPAPIARAIFLAHQWIPFCVAAPFQEAVADALEHADKSGFFDEFQVALCKKRDRLMDGLKQGGLPGILPHGGYFVLADTSSIWPKLQRDLQSGDANPSQPHDYTVCKQLTKSVGVVPIPPSSFFTPQHQPSVKDLARFAFCKEDRVIDEACRRLQAFGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJJ0</accession>
    <name>A0A0D2VJJ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364340.2">
        <property type="nucleotide sequence ID" value="XM_004364283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJJ0"/>
    <dbReference type="STRING" id="595528.A0A0D2VJJ0"/>
    <dbReference type="eggNOG" id="KOG0568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJJ0"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="1">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="316" mass="35953" checksum="90693F0E885ED713" modified="2015-04-29" version="1">MQPPSSIAFNLHTRPFAKNLTNKPSRRKRSHYRQQKSCTSKCLIFGMLHHSIDERDAPGETIAARQRNSQAIRLRQAVDNVHQHRVDAALRDAAEAHSNPDETKVSTRMAMAYADSVDLLKKQTQSIDKMVDDMIKNAMARGEFDNLKGVGKPLKMEEHQFLDTTTTKLNQVLINSGVLPEWINADKELREILPRLRQRTLDVWRSALQSLGTEDPRKQDESEAEHCTRIAGTLAKLEQALVDEGIDGILALLPLRQRQDLLSHREELLRDVAVANKKIASFNLIAPLLTQQKLLFDEARALRQHLAQCRSSLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJQ3</accession>
    <name>A0A0D2VJQ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">3-methylcrotonyl-CoA carboxylase biotin-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001568</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJQ3"/>
    <dbReference type="STRING" id="595528.A0A0D2VJQ3"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJQ3"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="80"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="199"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="671"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="752" mass="81601" checksum="E79711AE80295058" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM91</accession>
    <name>A0A0D2VM91_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349172.2">
        <property type="nucleotide sequence ID" value="XM_004349122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM91"/>
    <dbReference type="FunCoup" id="A0A0D2VM91">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VM91"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM91"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM91"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269393" evidence="3">
        <location>
            <begin position="22"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="64836" checksum="7838DFF63C1A5F98" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VND9</accession>
    <name>A0A0D2VND9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363746.1">
        <property type="nucleotide sequence ID" value="XM_004363689.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VND9"/>
    <dbReference type="InParanoid" id="A0A0D2VND9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="284" mass="30115" checksum="87B9397A5328F378" modified="2015-04-29" version="1">MAGIDDLMTDAQDAFFADDSVAATRLCARVLGLKRNEGDAYHLAHLALHSLRLHNAAMTVAQEWGVHCNESAKQLYAELVSAYLAGNSAVVEYAARALVRREDASVISKSVAIALAADLHHAVGSAETIRGFKTEDLPSDVLHFMDLLAAWTELSVGKAEAGLAELQSLATSHPTSGVATALLAVVLYELDQRAAAQELIAHNTTDTMSTRVARLIVNATTAPSGDVSAAHDDLGMLNGVPDLLTRRLDQSVRGDAPDTHNLAALFPRVPLAPVSRGPAEDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQF6</accession>
    <name>A0A0D2VQF6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQF6"/>
    <dbReference type="InParanoid" id="A0A0D2VQF6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="77" mass="8159" checksum="0345CE8DA506F0F6" modified="2015-04-29" version="1">MTQKRRSRPMPHRLESGQIRASPKVHTATGCARRSDATRNAQRPVIDGSGTSIERAGLGQCPTAGYGQPSTSPQGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRD3</accession>
    <name>A0A0D2VRD3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348035.2">
        <property type="nucleotide sequence ID" value="XM_004347985.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRD3"/>
    <dbReference type="eggNOG" id="KOG3688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRD3"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1464"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1564" mass="167650" checksum="DF2C0CD4E4203640" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSN3</accession>
    <name>A0A0D2VSN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_004797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSN3"/>
    <dbReference type="InParanoid" id="A0A0D2VSN3"/>
    <dbReference type="OrthoDB" id="17536at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16094">
        <property type="entry name" value="PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="263" mass="27037" checksum="075E5085FF1F94B1" modified="2015-04-29" version="1">MYAFHRFATAGAVSAAQGVPELVASMTSTAAAAKPQPKSAVAIKAAAKEFCHIYRNSALPDLLVCAVTAPVSPSEAFEFAATLLTHVHADRVLAFDAALKSSINGLYDDPENDDSDYDYDSGHRGALVCALATAAWRRDGRLPARALPTANMVTGAPAALLSHCEVIGTPAALLLALQESVEISPELLLAMDAVITSDNSQLGTVAPALAPLQADALRAAFKSAGPASDSALASVPGAIHLVLSASTTTAATFVRPTPDSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUP2</accession>
    <name>A0A0D2VUP2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346252.1">
        <property type="nucleotide sequence ID" value="XM_004346202.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUP2"/>
    <dbReference type="STRING" id="595528.A0A0D2VUP2"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUP2"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="254"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="779"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="90061" checksum="B3F726E72BD9CA93" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUY7</accession>
    <name>A0A0D2VUY7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUY7"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUY7"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37560" checksum="AE0D44BD0F5A3B48" modified="2015-04-29" version="1">MAGWPGPVPEFLDGPVISGLWQNQIGDAGASAIAETLKVNKAVTSIAIWDNQIGDAGASAIAQALKVNTTVTRLIIWRNQIGDAGASAVAEALKVNTTVTEFDLHKNLIGDAGAQAFAELVKVNKTLAWLNLSWNCIGEVGIQAIADAREFHHTRTALRIGNQCSPLVLSLLPRLATADELQTVFGLLTSGPELENQLASLPALPTEIADLIMDEACYWQGVQRTNRACYFDSLSVTVPTSSTGNSIRVKAIQVLLDVKHVDANDSEQCVVKLIVRDEQDAVRYECTAKPTLVDSTLRRVTILPANHPVMRQMREGWKVDVQPRKSSRGVRFESLHVGYIERQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVQ6</accession>
    <name>A0A0D2VVQ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345600.1">
        <property type="nucleotide sequence ID" value="XM_004345550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVQ6"/>
    <dbReference type="STRING" id="595528.A0A0D2VVQ6"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVQ6"/>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="273" mass="30488" checksum="4C186DDC133B24B1" modified="2015-04-29" version="1">MSSGHLRDKRQVSVGLRKPHVQSSDIPSPLYTFQYASSRDGIDSNLLILLHGMGDKCAPFFKFAERMQLPQTAILALQAPVPIMDFGFCWFESFDEDGELLAPSLSRYQSLKAVREGLESLINDVLVQPSFGWQRDRIFLLGFAQGGTVALDLALHGSGRLAGVISISGTLTEEELDVHVGDPVRADIARQTPILLTHGTKDEMIPIAEAHNRFDRLVRLVPEHPSLRLLQFPKGCKMIDSPEEMRAVMTFFSERLYLRNLAMENTPGIIPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW99</accession>
    <name>A0A0D2VW99_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344977.1">
        <property type="nucleotide sequence ID" value="XM_004344927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW99"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VW99"/>
    <dbReference type="OMA" id="TIMQCHT"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254544" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="7">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="649" mass="64632" checksum="6C041E7CF057AE62" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWF7</accession>
    <name>A0A0D2VWF7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PI31 proteasome regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWF7"/>
    <dbReference type="STRING" id="595528.A0A0D2VWF7"/>
    <dbReference type="eggNOG" id="KOG4761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWF7"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWF7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="327" mass="33751" checksum="D6272AEE7C37E2FB" modified="2015-04-29" version="1">MDSALVQQQLSESGARSRHDAALVAVHCALLSQGFVVVSSSANTPAARASGDGDGADASSNVASSTASSASLSISGALPPNWNASTSSNATDDANADIYVVRYCFGALTNAVFELKALVVASRLLVHIVAPADSSTVSDEIDVSGLDISTASTLMPVIKRTVDNVARSLRCKHTPATDPPAPSSSNAASTAASRSPSASSNLSDPLRMPTRGGPVYSPTYYPYDPLSVGEGDRRPVYSPTYGLLKQFEFHIFVALMPPPGVRPAPGFLPPGAVPPGARFDPIVGPVGPGNGWPGGVRPSGYRPAQRGPRSDPDPDHLPPPGYGDMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYW1</accession>
    <name>A0A0D2VYW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CAMK/CAMK1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343917.2">
        <property type="nucleotide sequence ID" value="XM_004343867.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYW1"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYW1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="516"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="629"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1522"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1565"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1357"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1655" mass="176327" checksum="898EF9DB2691B1FB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZG9</accession>
    <name>A0A0D2VZG9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZG9"/>
    <dbReference type="STRING" id="595528.A0A0D2VZG9"/>
    <dbReference type="eggNOG" id="KOG1923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZG9"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF10">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="448"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110192" checksum="1E3DBFF01D35FC45" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZV8</accession>
    <name>A0A0D2VZV8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZV8"/>
    <dbReference type="STRING" id="595528.A0A0D2VZV8"/>
    <dbReference type="eggNOG" id="KOG3585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZV8"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00182">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="152"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="780" mass="85299" checksum="7FD08F9E33C40AAE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0I4</accession>
    <name>A0A0D2W0I4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342890.1">
        <property type="nucleotide sequence ID" value="XM_004342841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0I4"/>
    <dbReference type="STRING" id="595528.A0A0D2W0I4"/>
    <dbReference type="eggNOG" id="KOG2657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0I4"/>
    <dbReference type="OMA" id="ECVYPGV"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="11">
        <location>
            <begin position="63"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="661" mass="70686" checksum="8D714989845979E9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0Y4</accession>
    <name>A0A0D2W0Y4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0Y4"/>
    <dbReference type="FunCoup" id="A0A0D2W0Y4">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0Y4"/>
    <dbReference type="InParanoid" id="A0A0D2W0Y4"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0Y4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="15938" checksum="A51530C992396D8D" modified="2015-04-29" version="1">MTKLVAVLKGDGAVKGTVVFTDDGAATKVEGTIEGLAPGKHGFHIHEFGDNTNGCISAGPHFNPAGKTHGAPEDEERHVGDLGNVEAGADGIAKFTITDNLIQVSGVNSIVGRSVVIHADIDDLGKGGHELSKTTGNAGGRLACGVIGVANAPVIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1V3</accession>
    <name>A0A0D2W1V3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346388">
        <property type="protein sequence ID" value="KJE98327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270931.1">
        <property type="nucleotide sequence ID" value="XM_011272629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1V3"/>
    <dbReference type="InParanoid" id="A0A0D2W1V3"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1V3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="582"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="894" mass="97811" checksum="B696142045417BC5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1Z4</accession>
    <name>A0A0D2W1Z4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346405">
        <property type="protein sequence ID" value="KJE98377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1Z4"/>
    <dbReference type="InParanoid" id="A0A0D2W1Z4"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1Z4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49567" checksum="5E8650AD8C6BEE79" modified="2015-04-29" version="1">MPRIGVAEAQAIAEALKENTTLTWLDLQRNQIGDAGAQVIAEVLKVNTTLTWLRLSDNQIGDIGAQAIAETLKVNSTVTDVDLNSSLIGDAGAQAIAEALKVNKTLTALQLQLNRIDLAGARAIAEALKVNTTVTRLYLNSSLTGDAGVQAIAEALRVNKTLSCLNLDFNQIGDGGAWAIAEALKVNTALTALLMELNQLGDAGAQAIAEALKVNTTLTSLRLEFNQIGDAGACAIAAALKANKTVTLLDLTSNCIGNLGSQAIDAARKRNCGCEVLLRDQINPLAFSLLPRLASAEDFQEVFGVLTSGLELQNQPPSLPALPTEIAELIMDKAHYWQGVQKTYRWWFDETTSSLKVTLPQGDSIRVKAIQVLRDWKRPNNIGDCAFDLTVRDEKGAVQYECAVHPTFVNRNLALATIGSASHPIVRQMREGWQVQVQPSTFAHELLFESLYVGYVDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGA7</accession>
    <name>A0A0D2WGA7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_009263</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGA7"/>
    <dbReference type="STRING" id="595528.A0A0D2WGA7"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGA7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="385"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1084" mass="117331" checksum="9EE833F0221D5756" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGZ3</accession>
    <name>A0A0D2WGZ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365236.2">
        <property type="nucleotide sequence ID" value="XM_004365179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGZ3"/>
    <dbReference type="InParanoid" id="A0A0D2WGZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="680" mass="73949" checksum="A0451314362A3243" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHZ7</accession>
    <name>A0A0D2WHZ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365003.1">
        <property type="nucleotide sequence ID" value="XM_004364946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHZ7"/>
    <dbReference type="InParanoid" id="A0A0D2WHZ7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49493" checksum="A41DFE4FDDDA11F9" modified="2015-04-29" version="1">MQRSASLQSSASDQSADDVFFDLIDVDGQPVAHEAGAQQPPQGSPAFAQLEPNALPPHPTASSGFNPNVAANMLAAPAAAASGGWTQEQQRHPQQAAVSFELATRPSPSQADDANAATVLHVSVSGDDVEDEFLDVSPVEVASIITDTVRPLFTSGSPVLSPTGLVDVPSNRSLGVSFAVPASSIGSSTGRFSSRPRSIRAQTTTSQSNHDDSSVADIKFRLASVRLKVSSFLGILISGFAFTALVEVKFGELPASVLVPYAVIASIQCTSSMIAFMMGSFIRPVINPSLIEGRKQNLAEYAQRREQRRLEQLTQPQQPSARATLQAPPSFASGLTVATSSESLLLWASNRSVQTRQGSRGDFAGSGRDPTAVAYDRFQVIITSVWLISTVSSVILFVASAAMIGYVRFYYHATAKIVSVVLISPFAAIFVVFAFYMYRLLMALELAYHKQRLDRARRLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI56</accession>
    <name>A0A0D2WI56_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000951</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365822.1">
        <property type="nucleotide sequence ID" value="XM_004365765.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI56"/>
    <dbReference type="STRING" id="595528.A0A0D2WI56"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI56"/>
    <dbReference type="OMA" id="TAHDETI"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="458" mass="48025" checksum="A5D74E6EDD1FEBD5" modified="2015-04-29" version="1">MASESTSAGLALEQPQPADSITTTTTTTPTTTSSSSSSSSSAGAGAGAGTTSLREDLLDTATKFLRNPKVQQAPKAKRVAFLEQKGLTAAEIDEAFRRVGPDAPPSQPAAVGSSIQPAQQQQHAQQAIATIHGHLQQQQLPPMGYAPQPQQYPAQQYAGQYGPPQQYYNQQQQPFMMMPPPPPPPHEVALAPLGWKDYAVASAALGAAGYGVWRLTRQFITPHLPEWLVRPDSAADGATTATTTETNEDNSANSNNSNNSNFRQHLDSSLNELKQSVAATVSSVRELADAHKMQADQNEVVMQSLSSDVALLKSMIASPTFGASSAASQDAALAELRSELASLKGLLLNRKQFPSTPSGSSTGFAAAGAASPTPGTPSSSSASLPAWQRSYMVKRPTPPVDSPKNDGTVETTRDEIASASAPTTTTPATVENGTVLETSANDLPAREDSPTPVEQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIA5</accession>
    <name>A0A0D2WIA5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="11">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_000285</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="11"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365156.2">
        <property type="nucleotide sequence ID" value="XM_004365099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIA5"/>
    <dbReference type="STRING" id="595528.A0A0D2WIA5"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIA5"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIA5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254471" description="Alkylglycerol monooxygenase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="17">
        <location>
            <begin position="157"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="18">
        <location>
            <begin position="368"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="490"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="58818" checksum="A0071C989EAD4CA7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIJ6</accession>
    <name>A0A0D2WIJ6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365327.1">
        <property type="nucleotide sequence ID" value="XM_004365270.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIJ6"/>
    <dbReference type="FunCoup" id="A0A0D2WIJ6">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIJ6"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIJ6"/>
    <dbReference type="OMA" id="HSIKNMI"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIJ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47426" checksum="DA776514ACE7D72E" modified="2015-04-29" version="1">MSARPTKRPASESDEGRRTKARTSKRNPSKDEDDDAGYHTSDSEPEFDAAPTRSSSSAAAPSTSSSSSSSSSSSSAAAASVGGAGKQKSSAASAGAKHADLAAAAPRGARGKKASADQASEDEDDADNADDDDDAEDDDDNGQDDGADEDGMEELVGPDEEIQVEFDAVGPEEADFFGIKAILEHWFLGVNTINTSEIADTVVAQAAQQDIGSVIKVVDAYGEIYGVMSVINMQTHKELDCIKQIRHYVLSKCANAPNNMATRLAPILEGSQGHVGLIINERFINIPFQLAPPLHASLHQQIKLALEDGEAFDFSHYLFVMKAYKDLPLLNDEVEAESAAAAAASGKKPAAKPKRANIVISKPDASVPLEYVNPEDEIFVKHASMSYTFALPVTASGTSGVKRSLHDTQLKLFRTVALLTREQAETALEEIAESLTGGVVTDLLGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ55</accession>
    <name>A0A0D2WJ55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001406</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349926.1">
        <property type="nucleotide sequence ID" value="XM_004349876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ55"/>
    <dbReference type="FunCoup" id="A0A0D2WJ55">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJ55"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ55"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="261"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="140"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="447" mass="51511" checksum="58138BA15DE44BCB" modified="2015-04-29" version="1">MASGTQQHVAFSFPLLKRNEILGILNDLRIPITEDDLREPSATSMRFLYENFVELIVGINKEDLAQPQFEAAAMLEYPELHNESLSEFVFSSALQRLMQICGIKDFSMNDVLKPDQNRTRTILSALINFTKFREEHLVHYQDLVAETDQLHDRMQQLEETTQHLASQVRMIRAQREDEQPAVDEVHKQVDVLEVEINTLNKLQAQLHGESRKIKDEITAQADQAANLKFSIENARQDCARLRSQIVPAPDKLKKEIVDMNASLVHEKELRANADRRARDMSAKLEALNKAQLDMRKATALLEDVGAQMGKHRETLREIDNTQEGIQVQQRRAAELSAKEQHVRKQLAQMQERHSRLLHQQDMKREAAGQAVDTMRQEREAVENERQNAMAKMEKNATYIKELNEKRTQVLQAHATEIQNIHVLHMQLFNQVGEYHQKLLDSIDGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJJ9</accession>
    <name>A0A0D2WJJ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364456.2">
        <property type="nucleotide sequence ID" value="XM_004364399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJJ9"/>
    <dbReference type="FunCoup" id="A0A0D2WJJ9">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJJ9"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJJ9"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="339" mass="38084" checksum="2C2D5927922800F7" modified="2015-04-29" version="1">MEDETGFAGFGIELGVNDDELDVAAEAARADRSFARKGRRGPQVMTDTELAALRDKRRELRLSKKKRRQARATQGLRAPTPWRTRRPVNMDRTTLADQRIVVDLDWEPWMSQHDLVCLHRQLRYVVGSNQRLRRPLRVSLAGIGPGMQELIETFGKGEATRWPIERRREPYTELFPLESLVYLTGDSPNVLTELDPARVYVIGGMVDHNRHKGLCYAEAEARGVAHAKLPISQYFKLPTRSILTVNQVFAILGTVSAGADWKTALWHEVPKRKGMIELEGQAEQHDEDDGDDDGDAAGETDDDGDDDDDDDDDDLSDDLSDDLSENSDNDGFDDEPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJL9</accession>
    <name>A0A0D2WJL9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LBP/BPI/CETP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364491.1">
        <property type="nucleotide sequence ID" value="XM_004364434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WJL9"/>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJL9"/>
    <dbReference type="OMA" id="TEPPMIN"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254505" evidence="7">
        <location>
            <begin position="36"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="9">
        <location>
            <begin position="281"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="532" mass="56380" checksum="85F51D915968A4B7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJY3</accession>
    <name>A0A0D2WJY3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="3">2.7.7.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJY3"/>
    <dbReference type="STRING" id="595528.A0A0D2WJY3"/>
    <dbReference type="eggNOG" id="ENOG502QS1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJY3"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJY3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="631" mass="70487" checksum="93CB0A28AD45E158" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKM0</accession>
    <name>A0A0D2WKM0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364378.1">
        <property type="nucleotide sequence ID" value="XM_004364321.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKM0"/>
    <dbReference type="FunCoup" id="A0A0D2WKM0">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKM0"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKM0"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKM0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000005">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="160" mass="18716" checksum="A520CC7C8DE4DD77" modified="2015-04-29" version="1">MIQFVLLFSRQGKVRLQKWFSAFSQKDKKKITREMTSTILARKPKMCNFLEWKEFKIVYKRYASLFFACAIDPNDNELIALEIIHRYVELLDKYFGSVCELDIIFNFEKAYFVLDELIINGELQESSRKSVLKSAATQDQLQEENEGMGNPIDDLIGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL93</accession>
    <name>A0A0D2WL93_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349201.1">
        <property type="nucleotide sequence ID" value="XM_004349151.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL93"/>
    <dbReference type="FunCoup" id="A0A0D2WL93">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WL93"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL93"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL93"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="515" mass="54579" checksum="1DAEB1A786FD894A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLB3</accession>
    <name>A0A0D2WLB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_008558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLB3"/>
    <dbReference type="STRING" id="595528.A0A0D2WLB3"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLB3"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TAP-C" evidence="8">
        <location>
            <begin position="676"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="730" mass="76693" checksum="DD8F14AD289F6396" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLL4</accession>
    <name>A0A0D2WLL4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 16">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_002042</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348792.1">
        <property type="nucleotide sequence ID" value="XM_004348742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLL4"/>
    <dbReference type="STRING" id="595528.A0A0D2WLL4"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLL4"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLL4"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="18">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="17">
        <location>
            <begin position="125"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE90798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="420" mass="45643" checksum="3B73430D3BF9F911" modified="2015-04-29" version="1">MSCWVDVPAGSDFPIQNLPYGVISTADAPSVRRIAVAIGAHALDLAATAHLFTDAAVQAAFAQPTLNQFMSLGRAAWSSARAEITAWLTSTASALHSDAALRARALIPLAHVTMHMPAQIGDYTDFYSSIDHATNVGIMFRGRENALMPNWKHLPVGYHGRASSIVVSGTPLRRPCGQTKADDEKAVPVYEPSKTLDFELEMAFFVGAGNKLGEPIPATRAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKNFGTTISPWVVTMDALAPFAVPNAVQDPQPLPYLRHDDAYTFDIKLEVAIKGENMAAPGVVTRSNFRHMYWTMKQQLAHHSVNGCNMQPGDLLASGTISGPEESSFGSMLELSWKGTRTIDLGGGEVRKFIKDNDEVIIRGHCEANGVRIGFGEASGKILPATPMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLR7</accession>
    <name>A0A0D2WLR7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLR7"/>
    <dbReference type="InParanoid" id="A0A0D2WLR7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLR7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39210">
        <property type="entry name" value="HEPARIN-SULFATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39210:SF1">
        <property type="entry name" value="HEPARIN-SULFATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254469" description="Heparinase II/III-like C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="751" mass="84522" checksum="22530BBD53ED862B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMH8</accession>
    <name>A0A0D2WMH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonucleoside-diphosphate reductase subunit M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMH8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMH8"/>
    <dbReference type="InParanoid" id="A0A0D2WMH8"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="63" mass="7056" checksum="FDC7C83E2C30F2FA" modified="2015-04-29" version="1">MFVKKRDGRTEKVMFDKITSRVNKLCYGLNSDYVDAVEITQKVSHPTQTGPLASRPAPPAHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMP8</accession>
    <name>A0A0D2WMP8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364027.1">
        <property type="nucleotide sequence ID" value="XM_004363970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMP8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMP8"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMP8"/>
    <dbReference type="OMA" id="CQIIVLK"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="403" mass="42786" checksum="D9709B1A1A2E2AD0" modified="2015-04-29" version="1">MTQTGLVTLSFEGQQRKLTTAADAEVVVSQLNATPGLQHLTLSGNTFGVEACVAICSALAPHAATLEVVNFSDIFTSRLHSEIRDAVTAFSAALVNMPKLREINFSDNAFGPIGAERLSPLIAGNRNLEVIRVNNNGLGSIGGTIVAKALCELANSDQPVRLHTFVAGRNRLENKGATALAHAFTQLKTLRLIAMPQNGIHYIGIGKLAEAFVSNPGLQVIDLNDNTFTSKGGKNMAKAIASLKTLKRINFGDCLARKAGGKALIEALTGGHELLEDLDLSYNELKPANAEQLIEALKTLTGLKQINVLGNEMSNKGVKKIKAALASGVQYTAPDEDDEDDQSCDDDDDDEEEEESEAEPEEEEQEEEEAAEESVPASAVKPSATAEVEVLTGQVAALNVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMQ7</accession>
    <name>A0A0D2WMQ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349382.1">
        <property type="nucleotide sequence ID" value="XM_004349332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMQ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WMQ7"/>
    <dbReference type="eggNOG" id="KOG3219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMQ7"/>
    <dbReference type="OMA" id="NMENEQA"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="375"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="480" mass="50327" checksum="D8E6291B64455707" modified="2015-04-29" version="1">MSDDSDYDFATEMSGAAGSGSGTAGSGSGTNAGSGSGGGNSLLAQLRGPTSSRPSPRSSAASSSLRTSTAAVPMFADDDLSGGGAGGGFGFVDESAKYYRHAKNVKSVPPEQRFTMSNFQIEQPGDARAFRAAPPGTATPEGRGSPTPGFGSSSSLSASGSGGGLLMAAASMAAAAGGGGGSSKSGFTNAPGMRPRPGGLMAIVPATPETGGSKRPRHQPQSSGKKPGRGRGGGDDDDDDDEFQVDEELLGGDSSSGNEEEDEDDSDAEFRPKRKKAHQDSDDDEEGSDASEHSDAREDEGEEDDEDDDDPEGAATLRRFRARHRAASAADGGDAAASGEAAKQEEENMENEQAITFAKDDDEIDLESDRDKLKLLVDAFTPEQLHRYECYRRSGFPRAVIRKVMQQQLNSAVSIPSVIVMAGIAKVFVGEIIEQARDVMVERDEGDKIQPAHIREALRRLRSKGVISERDPPKARLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMU3</accession>
    <name>A0A0D2WMU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMU3"/>
    <dbReference type="InParanoid" id="A0A0D2WMU3"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44413" checksum="EDE1EF7E4A384258" modified="2015-04-29" version="1">MSESQRELYDKVKNERGWLHLESNQIGDVGAQVVAEALKVNTTVTHLELGQNHISDVGARAIAETLKVNKTVAEVTLSWNQTGDAGARAIAETLKVNTTLTWLNLSSTQLGDAGARAIAETLKVNTTLEYLYLSRNRIGDAGAQAIAEAVKVNTNLIWIRLNTNRIGDAGAQAIAAALGENKTMTELHLGRNCIGKVGVQALREARKVNGILTELDIQGQINPLAFSLLPRLATCEDWQRVFHLLTGRHELENQPALLPALPAEIAELVMDKAEYLQGVQHIHQEWSREGYNQIDFLKLTMPRSSDGNSIRVKAIQVLREQSEAKSGRFDLIVRDEQGAVRYVWAAEALVVDSNIQLVTISPTDHPVIRQLRAGWEVEVPLSQYCSFVRFASLSVGYIERQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNW3</accession>
    <name>A0A0D2WNW3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363555.1">
        <property type="nucleotide sequence ID" value="XM_004363498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNW3"/>
    <dbReference type="FunCoup" id="A0A0D2WNW3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNW3"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNW3"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000027">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="33737" checksum="66C6A1BB81771789" modified="2015-04-29" version="1">MGSGSASLSSSSSSSVLHATLHGHRRNATPLRIVLLASTAAAFVSSIAPSSALQPRQLRFGNSNSGKYARSAAESADLAKACSSQNTASRSTKSSLKMAWRSHGTTNDGLVDALQRNGIIVSTEVEAAMRAVDRGDFTLTQPYQDSPQPIGHGATISAPHMHAHVLELLKGHLRPGMRVLDVGSGSGYLCACMAHMVGPAGKVVGIEHIPELVNMSLINLKRHHNEALEAGRIEIVVGDGRLGISGSQFDAIHVGAAAPTIPQSLVDQLKPGGRLVIPVGQSFGQSLEQVDKLPDGSIVTQHLMGVIYVPLTDREHQLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP06</accession>
    <name>A0A0D2WP06_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364123.1">
        <property type="nucleotide sequence ID" value="XM_004364066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP06"/>
    <dbReference type="STRING" id="595528.A0A0D2WP06"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP06"/>
    <dbReference type="OMA" id="TWGTVKK"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="257" mass="27323" checksum="742393B8541598E0" modified="2015-04-29" version="1">MEVESSSSADALAAKVAQALQERQQSAADAGAAATTTTTSAPSALKASLPLSRVKRIMRSDEDIGLLSADAVFLVTRATEMFVAEFAKKVSADLGKRKTVQYKDVANVVEQDTAYQFLADIIPQPVALGKVKGKPSTSGVAPGKIYPTNTPFVLQFANRRTEENGKHLLERRDPRRDKKKAASTRKTATAADAAKFFGGARQAGEDVDGEEDDGGDFQSSPSARRSSRPRQQSAALQGMDDGNDIGDEENGDDAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQG5</accession>
    <name>A0A0D2WQG5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347795.2">
        <property type="nucleotide sequence ID" value="XM_004347745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQG5"/>
    <dbReference type="STRING" id="595528.A0A0D2WQG5"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQG5"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQG5"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="226" mass="24487" checksum="84BB2C01FB3B574B" modified="2015-04-29" version="1">MQFSIVVAATRDALGIGLNNRLPWKLSGDMQYFKRLTLAPNAHSVAPTATAAATTASPAPDQTMASQTSDSRVVLESAVTTTTTTTATPPNAVIMGRSTWTSIPAKFRPLPDRLNVVLTSNPDARSLYEIPEHVLVEPSFSSALQTLEQLHANGTVNQVFVIGGAQVYATALQSPLLQRIYLTQINADIHCDVFMPPIDPAFRIVASEPRTENGIAYEFQVLQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQU9</accession>
    <name>A0A0D2WQU9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347546.1">
        <property type="nucleotide sequence ID" value="XM_004347496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQU9"/>
    <dbReference type="InParanoid" id="A0A0D2WQU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="719" mass="76051" checksum="45207F048B1C7391" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR52</accession>
    <name>A0A0D2WR52_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346679.1">
        <property type="nucleotide sequence ID" value="XM_004346629.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR52"/>
    <dbReference type="STRING" id="595528.A0A0D2WR52"/>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR52"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR52"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF74">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4 HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="260"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="684" mass="75463" checksum="6413F468FB79AC7B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR77</accession>
    <name>A0A0D2WR77_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348218.1">
        <property type="nucleotide sequence ID" value="XM_004348168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR77"/>
    <dbReference type="InParanoid" id="A0A0D2WR77"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024887">
        <property type="entry name" value="Ashwin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15323">
        <property type="entry name" value="Ashwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="316" mass="34487" checksum="4A5333FF533C35DD" modified="2015-04-29" version="1">MDAQTSPFNLSEGVQHPLPPPESSPVVDLMHPETMSVAALLQALTLHGVPLAQDSESNKDALVALFRRFVMPRPQRQHRRSAMLNERQASQGLSSKSPLLLRIPESTNHETLQRITQLGFHQSKDAVDSNANRKRAASRQLTAADCAELPNTNATGAWVSCSNARQRHGDALLQSMPASPAADMVISALKHARLESPNSEADEPFTLPIQALPPSTLLSDEHRHVVERISTPSHPSPRPRRTRRLSDELQSAHQLSHAEAAASATLNLGTASSEESAYNLHQSKRMRWDSASEQTPNSDAFHSLGSADTTTAMELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS53</accession>
    <name>A0A0D2WS53_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS53"/>
    <dbReference type="STRING" id="595528.A0A0D2WS53"/>
    <dbReference type="eggNOG" id="KOG2528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS53"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS53"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="165"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="510" mass="56968" checksum="6F86ED4AFAB155E7" modified="2015-04-29" version="1">MTQARALYDYEGGEGELSFFTDNVIQVTDKGSGDGWWMGVLNGQMGYFPESYLPSSPAARALPSRALPVPTAAAAADDEENWDDDDAEPVPATRGATRSTSNASSAGYGTAARRGTVRRNLNRFSAFVKTGGEAFLMAESIDKVPSDLVVRVVAGPRWLDAPQYFSVSVTEPTKKSKFHGVKSFIAYNVMPSHTGVAVSRRYKHFDWLYERLTEKFASLSIPPLPDKSAMGRYEEEFIKLRQQQLQRWLTRLARHPVISQCEALNHFLTCNGEEKEWKAGKRKAEKDECIGGKFFMCISAPDGNVPPDADTQVESFGKFVRGMERRMDKVRECGERFSSFSQDIKTEVQRVGHAFGDLTSDDWKDEGHPCTPLTKAIEFTSTTLNEIGQSFADQPAKDMTPLLADTAEYLGILPTYPSIVDTHTSAYNRLKETTKLQEQGKADGSDVAAVQQRCEVISNVTLSELDRFHTERNFDTKLSMETYLASQIEFYQQIVGKLQNALQKFQDIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSJ9</accession>
    <name>A0A0D2WSJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346310.1">
        <property type="nucleotide sequence ID" value="XM_004346260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSJ9"/>
    <dbReference type="eggNOG" id="ENOG502SPAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSJ9"/>
    <dbReference type="OrthoDB" id="10625938at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="455" mass="50650" checksum="4AC956D1F2389CAA" modified="2015-04-29" version="1">MLDTPKRTLPLHPDHEARLARRSSSELNSLAIFVSESRALDSPAPGALNPDDLDCCEPLEPLESLEPLEALESESEQPASEVEQVEECPPKQAEDNDDTTLPDSTESQSQEDALPSAKHTKSASLRLSVIHLLKVATIGTILCWLLFTTALPATRAVWSHFTALSILALAVVFARPIASVVTFCNLLAGPSAQDCKLKPQLRLNLHVTKTSLLDEVTMNELFTLALSTLDTNQSLSQSLDMFRSYVLSFDFVIMYRSKLDGSLRGMFLMGQESTHARPDGKSAAVLKVGLALFREGYHGGPWFPLAVLYIVLLTKLSRPFTQVYIIMKCFSIRSYLFAVRNAQECYPRHDMPTPAWEKTVMDGFGRAMTSPSEQYDAVHGVIERKNSHLKKGIAEISEKDKQDPHIRYFEEQNPDWQQGHQLVVMGAVSAGCFCRGVLSAARRYLGNSRWELRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSN3</accession>
    <name>A0A0D2WSN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vinculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346808.1">
        <property type="nucleotide sequence ID" value="XM_004346758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSN3"/>
    <dbReference type="STRING" id="595528.A0A0D2WSN3"/>
    <dbReference type="eggNOG" id="KOG3681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSN3"/>
    <dbReference type="OMA" id="ANNLCEL"/>
    <dbReference type="OrthoDB" id="29742at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="834" mass="88387" checksum="8F235B07AB5C4DFE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTA2</accession>
    <name>A0A0D2WTA2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTA2"/>
    <dbReference type="InParanoid" id="A0A0D2WTA2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="185" mass="21260" checksum="E97EDC63388DA66D" modified="2015-04-29" version="1">MGQYYICVVINDERRVVWAYSTFGGAKLMEHSYFGQRRVLAAMERLRHRPQRMVWVGDYADGEPDGTHLYSAGHEWESENHGDVNTKHWRESDSQDKSLKSEESLRFLVNHDRHEIIDLQVYLRDDVHPLPLLTAEGNGRGGGDFLGNGNVGIWSRQLISSETLLDAQVYIDLGYTKVEQFFTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU10</accession>
    <name>A0A0D2WU10_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346418.1">
        <property type="nucleotide sequence ID" value="XM_004346368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU10"/>
    <dbReference type="InParanoid" id="A0A0D2WU10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1241" mass="132194" checksum="DD2A94120113AC6C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUA1</accession>
    <name>A0A0D2WUA1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345502.1">
        <property type="nucleotide sequence ID" value="XM_004345452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUA1"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUA1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="115"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="483" mass="53977" checksum="AFFCFEFC0B1BC673" modified="2015-04-29" version="1">MQSKVWKRPLPIVVAVLVVLLVMRLTSTVSWESTLAGFSGQQHDDDDNDELGSEGELFDERCSPVKGGVPVHPKSQSDTNAAAAAALAAEIAAVPFQCMPSTLSSHLLDAPVGVLRIYVYKELLPSGDLLRDHCTAAGASAEVHFAKRPEEKYFLDWLATSKHATSNPNEAHFFIIPTPIECLFRITDDASLPALEVVQNVLNNHNYSIRAGHDHVLFTSSMAERAQTEVFHGASEQKYYSPVAVHFPNVILMSTESMYTQWFRPPRDIVIPPALNVDDYLDVLASSESEESFNEDRPQLCSYVGDFNSSAERKSIGDSATLRAKYTPVVTITDAVTAPAEVAAIYRQSSYCLAAQDETPSTMQMYEIMAAGCIPVLLTRNYLLPFPNHIDWELLIVRWLDEDIKGISIYIHLENLPRAHLVERRFLVRRARSLLTYGVERPSPPVAAFTHEDPHVRRRAYYTGPSGMIVRELADRFCRKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUI0</accession>
    <name>A0A0D2WUI0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344314.2">
        <property type="nucleotide sequence ID" value="XM_004344264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUI0"/>
    <dbReference type="STRING" id="595528.A0A0D2WUI0"/>
    <dbReference type="InParanoid" id="A0A0D2WUI0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="701" mass="75565" checksum="DDFA7E526D6A69BF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUP5</accession>
    <name>A0A0D2WUP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345730.2">
        <property type="nucleotide sequence ID" value="XM_004345680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUP5"/>
    <dbReference type="InParanoid" id="A0A0D2WUP5"/>
    <dbReference type="OrthoDB" id="194033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="405"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="405"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="605"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="605"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="977" mass="100413" checksum="4B5946578C35711E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUW3</accession>
    <name>A0A0D2WUW3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344991.1">
        <property type="nucleotide sequence ID" value="XM_004344941.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUW3"/>
    <dbReference type="FunCoup" id="A0A0D2WUW3">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUW3"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUW3"/>
    <dbReference type="OMA" id="IVERVYI"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="180"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="349"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="930"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="969"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="771"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131777" checksum="91E16847A65B1A3A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV58</accession>
    <name>A0A0D2WV58_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345132.1">
        <property type="nucleotide sequence ID" value="XM_004345082.1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV58"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270201" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1411"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1457" mass="153890" checksum="48E3A849B6C654F6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVT5</accession>
    <name>A0A0D2WVT5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_010014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVT5"/>
    <dbReference type="STRING" id="595528.A0A0D2WVT5"/>
    <dbReference type="InParanoid" id="A0A0D2WVT5"/>
    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="741" mass="75611" checksum="77AF54DFDEF13FBB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWW3</accession>
    <name>A0A0D2WWW3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxysterol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343249.2">
        <property type="nucleotide sequence ID" value="XM_004343199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWW3"/>
    <dbReference type="STRING" id="595528.A0A0D2WWW3"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWW3"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="242"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119097" checksum="5B880E452C46D3CA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX99</accession>
    <name>A0A0D2WX99_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-1,4-N-acetyl-galactosaminyl transferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342953.1">
        <property type="nucleotide sequence ID" value="XM_004342903.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX99"/>
    <dbReference type="STRING" id="595528.A0A0D2WX99"/>
    <dbReference type="eggNOG" id="KOG3588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX99"/>
    <dbReference type="OMA" id="VNMHVFE"/>
    <dbReference type="OrthoDB" id="5971499at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF5">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254868" evidence="10">
        <location>
            <begin position="27"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="147"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="728" mass="81713" checksum="1465D72F14FF642E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXK1</accession>
    <name>A0A0D2WXK1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXK1"/>
    <dbReference type="FunCoup" id="A0A0D2WXK1">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXK1"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXK1"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXK1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052677">
        <property type="entry name" value="Dinucleoside_ppp_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46981">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46981:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="116" mass="13332" checksum="B78827AE46AC6D7C" modified="2015-04-29" version="1">MLVAPLRVVHRFTDLNPDEIADLFQTTQRVSRAIEIAYKSIALTIAIQDGVGAGQTVEHVHVHIIPRHKDDFVPNDKIYHELDQHDKEAQRRARTSQEMADEATWFRQFLAMDTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXW0</accession>
    <name>A0A0D2WXW0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342841.1">
        <property type="nucleotide sequence ID" value="XM_004342792.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXW0"/>
    <dbReference type="STRING" id="595528.A0A0D2WXW0"/>
    <dbReference type="InParanoid" id="A0A0D2WXW0"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1209" mass="130911" checksum="5EE48740D1419076" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0I9</accession>
    <name>A0A0D2X0I9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_000672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365543.1">
        <property type="nucleotide sequence ID" value="XM_004365486.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0I9"/>
    <dbReference type="eggNOG" id="KOG4521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0I9"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0I9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056547">
        <property type="entry name" value="NUP160_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23345">
        <property type="entry name" value="NUP160_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="199"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="490"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 helical" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="8">
        <location>
            <begin position="1216"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE89139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1867" mass="201328" checksum="08CF5E9399F38280" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0K9</accession>
    <name>A0A0D2X0K9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0K9"/>
    <dbReference type="InParanoid" id="A0A0D2X0K9"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270309" evidence="2">
        <location>
            <begin position="29"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="323" mass="34630" checksum="85ED4164F195F4E2" modified="2015-04-29" version="1">MPLEAPRFKILAVFACLVLIITWALVWSESAIPPDTPEADHAADASPSLLPNNVLPQVVDHAAVVLSDPSTTGAAFASCIASATDSLADSLAAEPSHSESDQPTPTPLDLTPSPPTSPTATSLPSAAPAAQTPSPTTQAQSTTQAPSPAEPALPTSQASSASPRGWYQLPADHPRVLARLVAYADWNKTFDIYPPPSIWQCPYEDEARWFWDTDTVAEIGVDWKTALTVALTNKTVGIHGDSLTLQTVSVFLNLVESAGFELVKVKRINRVTGYFPALNFTLIANYVPYIVDMLGEKPYPQLSLDRLSQAFTIMADAADYSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X168</accession>
    <name>A0A0D2X168_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X168"/>
    <dbReference type="InParanoid" id="A0A0D2X168"/>
    <dbReference type="PhylomeDB" id="A0A0D2X168"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="218" mass="23387" checksum="1C9C9DCC8C626610" modified="2015-04-29" version="1">MESDYVETSPGSGVLQHYANGSSKAVGFRWSCRIQLTTDLDENWLAGGIVHYVVHPTVADMTIAEFQAELLALFSTQCGVGMGSDSGLSGSTSALSIGGSSTVSGKTMDAMTIAAAPNCIKPVLAALRTHVNQYADVDPTRALVSSMVHDNLALRQFSLDDAMQHEDLCWYLYCATLQTTFSLGALQFRDQVNDFLVGAEVKTDKPSHPASSEPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1U5</accession>
    <name>A0A0D2X1U5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pectoralis alpha actinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1U5"/>
    <dbReference type="FunCoup" id="A0A0D2X1U5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1U5"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1U5"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1U5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000088">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254968" evidence="7">
        <location>
            <begin position="33"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="59"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="172"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="763"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="901" mass="101500" checksum="EBBC66FC043ADE8F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Z0</accession>
    <name>A0A0D2X1Z0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Z0"/>
    <dbReference type="InParanoid" id="A0A0D2X1Z0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="106" mass="11935" checksum="69252E7E90DCA8FA" modified="2015-04-29" version="1">MQCQRRRGVARTAKPRPERGKRGLQTSFVGSTERMQPPMHGLVVDSDVPDVYVVYSVSQMWRNGLVCDLQICRLLSAFLFFSVDAEGPSILLGAQLKPALFRNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X203</accession>
    <name>A0A0D2X203_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptosome-associated protein 25a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348618.2">
        <property type="nucleotide sequence ID" value="XM_004348568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X203"/>
    <dbReference type="STRING" id="595528.A0A0D2X203"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X203"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X203"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="243" mass="26786" checksum="436E840053151A5D" modified="2015-04-29" version="1">MAKKTTALPAEPKEQNSQVVQDMLREADEITNESLEASRRIKQLAMESAEVGGRTVETLQEQGRQLNRIDRNLDNVNEDLRGAEKTLTKMEKVCGLCRCPCGKAKKFESTEMYERDTFDPDHSKDPNKKGKNKGKGKEAAAAAGGATAVVDKQPTSLSNGREDDGMFIKQVTHDHREAEINENIGAVADILGDLRHQAMVMGTELDKHNEVLDRIEKKTDSNTARVDEANIRATKLLGGKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2C8</accession>
    <name>A0A0D2X2C8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAOG_003321</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364160.2">
        <property type="nucleotide sequence ID" value="XM_004364103.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2C8"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2C8"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="444"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="1000"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="1545"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="864"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1461"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1649"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1284"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1307"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1481"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1649"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJE92334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1670" mass="177582" checksum="734D21ECB5CF043D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X328</accession>
    <name>A0A0D2X328_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348177.1">
        <property type="nucleotide sequence ID" value="XM_004348127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X328"/>
    <dbReference type="FunCoup" id="A0A0D2X328">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X328"/>
    <dbReference type="eggNOG" id="KOG4267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X328"/>
    <dbReference type="OMA" id="CATSALM"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X328"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="10970" checksum="ED6A10F829E6ED86" modified="2015-04-29" version="1">MQVSPHDPAVINTAVGALVAIGGIAGFAKSRSAPSLIAGVSFGAIYAYSGYLIAHGNPVLGHQIAAGASLLLAGTMGTRALRTGKFMPAGLVAGIAVAALAYNLPRAQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Y2</accession>
    <name>A0A0D2X3Y2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346266.1">
        <property type="nucleotide sequence ID" value="XM_004346216.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Y2"/>
    <dbReference type="FunCoup" id="A0A0D2X3Y2">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3Y2"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3Y2"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3Y2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="861" mass="97305" checksum="D1E05A1E675EF07A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4D2</accession>
    <name>A0A0D2X4D2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription elongation factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345006.1">
        <property type="nucleotide sequence ID" value="XM_004344956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4D2"/>
    <dbReference type="FunCoup" id="A0A0D2X4D2">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4D2"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4D2"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4D2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="145"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="433" mass="47020" checksum="73B71F62CD172C6A" modified="2015-04-29" version="1">MSEADTRTALAEYGRQLEALASDNADRSLVVLSELAKQPISVTLLSDTGIGKIVNNFGKRATNAAVQAEAKRVVALWKTACNAEGAAAPATPTPVPAGFASQTQNAPTPTVSRAESSGSAPAEPARRSSVNSNAISTLVHTGDAHRDSCIKALAKALDPTVTDETQISEYFVSLAQSIEASIYKLHNSEVSPKYKTAVRSKMFNLKQNEDFRKAVLNGSIPPEKVAVMTSEEMATKELNAERKKLTTEAMNDAQMPAPKMSKTDQLRCGKCGKRDASYFQLQTRSSDEPMTTFVTCNVCGHNWKDDDSDCRAGGSNPATSTLGSRNSRLTQRRFSIAAAKMMQKIWGTALVEHLSSEFEYKLHTLLITAARIRAEEKYLRAVEGSHVFPATLPDMPTIMYCDPTPIAAKHHDPADYTNRTEQRILVVPKLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4F3</accession>
    <name>A0A0D2X4F3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4F3"/>
    <dbReference type="FunCoup" id="A0A0D2X4F3">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4F3"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4F3"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4F3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255047" evidence="5">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="23574" checksum="0732D7C774EE40F9" modified="2015-04-29" version="1">MGRILLILGLAFLSDRSLFSYFAMGIDIKYKHLKKKVRTEPKSEDLYIRLLVKLYRFLARRTDSPFNKVVLKRLFQSRIHRPPLSLSKLVRLTKGSEKLTAVVVGTVTDDERLHVVPKLTVCALRFTAAARARILKAGGETITFDQLALRSPTGKNTLLLRGPVKSREAVKHFGAAPGVPKSTTKPYVRSKGRKFEKARGRRASRGYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4K5</accession>
    <name>A0A0D2X4K5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345323.1">
        <property type="nucleotide sequence ID" value="XM_004345273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4K5"/>
    <dbReference type="InParanoid" id="A0A0D2X4K5"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE96219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="777" mass="84233" checksum="4AF20D65D2873931" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4X2</accession>
    <name>A0A0D2X4X2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343796.1">
        <property type="nucleotide sequence ID" value="XM_004343746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4X2"/>
    <dbReference type="FunCoup" id="A0A0D2X4X2">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4X2"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4X2"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4X2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000615">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="316" mass="35114" checksum="DC946CEF4AF68531" modified="2015-04-29" version="1">MAEQLTLRGTLKGHSGWVTQIATTPEVPDLLVSASRDKSLIIWNLTRDETNYGVPKRRLQGHNHFVSDVVISSDGQFALSGSWDHTLRLWDLNSGVTTRRFVGHTSDVLSVAFSADNRQIVSGSRDKSIRLWNTLGECKFVIQEDGHSEWVSSVRFSPNTSNPNIVSVGWDRVVKVWNLNNCKLRTNHYGHTGYVNTVTVSPDGSLCASGGKDGVAMLWDLNEGKHLYTLEAGDEINALVFSPNRYWLCAASGASIKIWDLESKNLVDDLRPEFLSVGKKSQLPQCISLAWSADGQTLFAGYTDNVIRVWQVTRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X537</accession>
    <name>A0A0D2X537_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X537"/>
    <dbReference type="InParanoid" id="A0A0D2X537"/>
    <dbReference type="OrthoDB" id="192748at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="172" mass="19080" checksum="C64E7AE57FCB014D" modified="2015-04-29" version="1">MFALAGRVSRQAVTLVPRLPRHCASASRPSAAAALALTHPYALTRPQSIRNSTSSSTSTSSTDKKAQQKAQDDAAERDLSLPVLFPNNQGTLQNIARLAAAFVVFWGVWMADYGDHEHVFSPIRRWTDELLDQFRQVSLEEKLAAQQRAKEQIEQLKQQQQAQPTSLKPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X547</accession>
    <name>A0A0D2X547_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X547"/>
    <dbReference type="STRING" id="595528.A0A0D2X547"/>
    <dbReference type="InParanoid" id="A0A0D2X547"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="528" mass="56810" checksum="410E811B8092B04B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZR8</accession>
    <name>A0A0D2TZR8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZR8"/>
    <dbReference type="STRING" id="595528.A0A0D2TZR8"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZR8"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF47">
        <property type="entry name" value="LIPOPOLYSACCHARIDE 1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127952" checksum="7DF3FF3FA677D51C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZW3</accession>
    <name>A0A0D2TZW3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364991.2">
        <property type="nucleotide sequence ID" value="XM_004364934.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZW3"/>
    <dbReference type="eggNOG" id="ENOG502SPAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2TZW3"/>
    <dbReference type="OrthoDB" id="10625938at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2TZW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="405" mass="45608" checksum="4DBC5037C776F5D5" modified="2015-04-29" version="1">MTLVNLTTSSPVSFVSLLGITPQDVSAWFDPSAASASSSSASMLADTSAHGVFGTLVWTLTALWTRLGELAIAIPLSSIMLFVLVAPLVYYILRPIIKLELLHHIAKNGSSKKTVYGSLFAYCVRTELLDDAALHELLVLAHDMVDVRSESELELFHRYLLSFLYVIIFRDQVDGSLRGMFLIDRERGQSYNGKSFTLFKTGLALFKASNRGGPLIYLAFFYFFIKELIWHPFTPLYGVFKCFSVKSYLMAKRSSESVWPQAGVPTPAWEQSLIDSFGVKTATGQEVYDPVTGVINRTTTALRPDVAPISEEDLKNPDIRFFAERNPRWDQGHLLVVLYKITWGCVFKSIVAILRKTFRVKAQQKLLRIQSKHRLLRSPSVKDRFEQARRVTVVDPLTNCQADTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0E5</accession>
    <name>A0A0D2U0E5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365163.1">
        <property type="nucleotide sequence ID" value="XM_004365106.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U0E5"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0E5"/>
    <dbReference type="OMA" id="CIFLDEV"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0E5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="391"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="719"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="921"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1355"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1538"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="602"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1361"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1383"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1582" mass="167651" checksum="F71441FC3472E7A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1Y0</accession>
    <name>A0A0D2U1Y0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1Y0"/>
    <dbReference type="STRING" id="595528.A0A0D2U1Y0"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1Y0"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1Y0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="541"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="704" mass="75164" checksum="3B5604D7FA78F66C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U814</accession>
    <name>A0A0D2U814_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349156.1">
        <property type="nucleotide sequence ID" value="XM_004349106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U814"/>
    <dbReference type="STRING" id="595528.A0A0D2U814"/>
    <dbReference type="eggNOG" id="ENOG502SF3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U814"/>
    <dbReference type="OrthoDB" id="2102136at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="487"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="849"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="913" mass="101561" checksum="AF3573A7DC3F2C4F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCL0</accession>
    <name>A0A0D2UCL0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363405.1">
        <property type="nucleotide sequence ID" value="XM_004363348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCL0"/>
    <dbReference type="InParanoid" id="A0A0D2UCL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="384" mass="40652" checksum="FCC9D65D7004F4D6" modified="2015-04-29" version="1">MLLRVGVRTLRRGLATISASRPTPHQQPTVQCVQVLTRLQSSTAAAAAAVPPQQVEALLRSLVADPTSSSTGAAAAAAAAAAASTLPIHDLSRMLASQTNPVALAEFEHYLRSLSVDQRVRFLATMVYKPGEAHLAGTSAQDSIHAVEPSNELASNSGPALTGRAATRQEVHSSDAFKSPSSTSTSSTAPNVDASVVVMPERGADVRQTDSQLVMAKQVIELVSLFNHGTRKLTGSVLALMAFALIAPLLVLNKLLDDAMENISTDLIQIGGKFNPDPQVFANNLRQYYYDILRQQSTQTQQSPASQVLDQQVQALQAQVAQLEQRLAAAQSTPQAVQAAAPPTIPPALHPTADSTSTAALVEPLRQPVSVQHPIPLENDQTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCM1</accession>
    <name>A0A0D2UCM1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363418.1">
        <property type="nucleotide sequence ID" value="XM_004363361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCM1"/>
    <dbReference type="STRING" id="595528.A0A0D2UCM1"/>
    <dbReference type="InParanoid" id="A0A0D2UCM1"/>
    <dbReference type="OMA" id="QARIEMQ"/>
    <dbReference type="OrthoDB" id="10047268at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF11">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="815"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="874" mass="90364" checksum="E1E9A4F78273629D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDW7</accession>
    <name>A0A0D2UDW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2UDW7">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDW7"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDW7"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="730"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1668" mass="180379" checksum="8B9A6D691038C484" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEC3</accession>
    <name>A0A0D2UEC3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13">2.1.1.17</ecNumber>
            <ecNumber evidence="13">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phospholipid methyltransferase</fullName>
            <shortName evidence="13">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_004263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13"/>
    <dbReference type="EC" id="2.1.1.71" evidence="13"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEC3"/>
    <dbReference type="STRING" id="595528.A0A0D2UEC3"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEC3"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEC3"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000024">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF11">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="13">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="13">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="13">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE93476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="237" mass="26047" checksum="70A893C701014345" modified="2015-04-29" version="1">MIHVQVHLYTPIPNLITWRIRVMIWGSCTVFFSPVPQQRTMSALAAVLVAPLAAIVLHVANYNATAQIEHKTRCFTKILGANAVYYYAVYLVLSAAVRDAVIHSAIEASLPELQWIVLPVEIATIVGYGLFVVGILLNLWTLHALGIKGMYNGDSFGFLMDAPVTSGPYTIFSDPQYVGTTLAMFGAALRQQSIVGYALTLAMGIVFWISVKFIEGPHLQRLYSKKPSSSSKSAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJQ3</accession>
    <name>A0A0D2UJQ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJQ3"/>
    <dbReference type="STRING" id="595528.A0A0D2UJQ3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJQ3"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252859" description="LRRNT domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="8">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="743" mass="76198" checksum="DE61721374577C17" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKA1</accession>
    <name>A0A0D2UKA1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345564.1">
        <property type="nucleotide sequence ID" value="XM_004345514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKA1"/>
    <dbReference type="STRING" id="595528.A0A0D2UKA1"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKA1"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252716" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="61556" checksum="88214ACC8DD94C27" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKX7</accession>
    <name>A0A0D2UKX7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKX7"/>
    <dbReference type="STRING" id="595528.A0A0D2UKX7"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKX7"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000002">
        <property type="entry name" value="Sortilin-related receptor isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF47">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268644" description="PKD domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="9">
        <location>
            <begin position="785"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="9">
        <location>
            <begin position="879"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110393" checksum="A2A99EBBDA08D74F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULS8</accession>
    <name>A0A0D2ULS8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345169.1">
        <property type="nucleotide sequence ID" value="XM_004345119.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULS8"/>
    <dbReference type="STRING" id="595528.A0A0D2ULS8"/>
    <dbReference type="eggNOG" id="KOG1095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULS8"/>
    <dbReference type="OMA" id="YASFANN"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268670" evidence="12">
        <location>
            <begin position="46"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="475"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="741" mass="79092" checksum="2609170030C929C9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UN66</accession>
    <name>A0A0D2UN66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344410.1">
        <property type="nucleotide sequence ID" value="XM_004344360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UN66"/>
    <dbReference type="FunCoup" id="A0A0D2UN66">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UN66"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UN66"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UN66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="112" mass="13010" checksum="75EEAB107D1B5621" modified="2015-04-29" version="1">MLVFCPTCSNLLVAGTYQDSRENVMFRCATCPYVYQVQSMIGNMREMNKKEVDDVMGRESDWDNVDQTDANCPKCGHTKAYYRQVQTRSADEPMTIFLRCSNMECKHNWRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP58</accession>
    <name>A0A0D2UP58_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343771.2">
        <property type="nucleotide sequence ID" value="XM_004343721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UP58"/>
    <dbReference type="FunCoup" id="A0A0D2UP58">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP58"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP58"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="423" mass="47024" checksum="6366E01E57FDE784" modified="2015-04-29" version="1">MSFHLSDAYARKLEQYELSTKLGEGTYASVFRAIHKPSSTLVALKQINLNRDEGTPCTALREISLLKELRHANIVALLDVAHTRERLTLIFEHLDCDLKQHMDACGKNLAPANVQLILYQVLRGIAYCHSKSILHRDLKPQNLLLNRATGDVKLADFGLARAFGIPVKAFSHEVVTLWYRPPDVLMGSQVYSTSIDMWSIGCIFGEMTTGRPLFAGKNVDEQLARIFKQRGTPTELTWPGVSQLPNFRGDFPVTPAVQLASIVPKMDSLGVTLLNRLLQYNPAMRVSAAEALQHVYFASIHAIVGNLPNEQSIFDRTGITMILEPPVEAAQAPAASTAAAAAAVPAPIAQQQQDISQQQQAFQDQQQRELQLTRMQQMSQFQQFQQLQAHQHLLAQPNHVVNNNNNNSSSQAHPSHLDSQFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URS2</accession>
    <name>A0A0D2URS2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URS2"/>
    <dbReference type="STRING" id="595528.A0A0D2URS2"/>
    <dbReference type="InParanoid" id="A0A0D2URS2"/>
    <dbReference type="OrthoDB" id="6138780at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252858" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="38"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="813" mass="82346" checksum="8FDD680E703BE83C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URZ8</accession>
    <name>A0A0D2URZ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URZ8"/>
    <dbReference type="FunCoup" id="A0A0D2URZ8">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2URZ8"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URZ8"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URZ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="105"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119069" checksum="C5495D2FF5CFB904" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFP8</accession>
    <name>A0A0D2VFP8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 26B-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFP8"/>
    <dbReference type="FunCoup" id="A0A0D2VFP8">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFP8"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFP8"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269251" evidence="4">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="318" mass="37279" checksum="C6818AFAEF4C9B76" modified="2015-04-29" version="1">MTFPSIFLFIQSFFGFGQTAQIDIVLDDKSTRPQIEVKDEEGHKNQLYLFLDGETVKGQVHINLKTPGKKLEHNGIKVEFLGQIEMFYDRGNHHEFTSLVRELAPPGEMTRSQTFQFEFQNVEKSHESYNGINVRLRYLLRVTIVRRLADITKELDLWVHQYSILPKINNSIKMEVGIEDCLHIEFEYSKSKYYLKDAIVGKIYFLLVRIKIKHMELAIIKRESTGTGPNVYNESETITKYEIMDGAPVRGESIPIRLFLAGFELAPTMRDINKKFSVRYYLNLVLVDEEERRYFKQQEITLWRKKEDGETAEQYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGG8</accession>
    <name>A0A0D2VGG8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365403.1">
        <property type="nucleotide sequence ID" value="XM_004365346.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGG8"/>
    <dbReference type="eggNOG" id="ENOG502S7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGG8"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGG8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="951"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1986" mass="216284" checksum="61788A6A100FCEF0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHM2</accession>
    <name>A0A0D2VHM2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHM2"/>
    <dbReference type="STRING" id="595528.A0A0D2VHM2"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VHM2"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VHM2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06142">
        <property type="entry name" value="RNaseD_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051086">
        <property type="entry name" value="RNase_D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47649">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47649:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="58905" checksum="534B8C17B4D6C987" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIZ5</accession>
    <name>A0A0D2VIZ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIZ5"/>
    <dbReference type="STRING" id="595528.A0A0D2VIZ5"/>
    <dbReference type="eggNOG" id="KOG3820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIZ5"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIZ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04880">
        <property type="entry name" value="ACT_AAAH-PDT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="10">
        <location>
            <begin position="96"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="390" mass="43678" checksum="14EEA5AA19DEDDE0" modified="2015-04-29" version="1">MTDSAVSAAAASPATNSYRPDAAPKDTSVLFAVEEKVGALQDILGFFSTNNISLKHIESRPSKSEGQYDFFVTIDAKYADQLAVVLPQLKGIVNNCQLFNSELSAANAPWFPRKISDLDMYANTILSYGAELESDHPGFSDPVYRERRAMLADLAIKYRHGQKLPHVNYTPEEVATWGRVLTELTKLYPQYACKEHCRVFPLLIDNCGYRPDNVPQLEVVSNFLKDCTGFRLRPVAGLLSSRDFLNGLAFRVFHSTQYIRHHTAPLYTPEPDVCHELLGHVPLFADPSFADFSQEIGLASLGASDEDIEKLATCYWFTIEFGLCRQDGKVKAYGAGLLSSFGELEYSVSDKPEHRPFDPPKTAEQKYPITEYQPVYFVADSFDDAKDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJN0</accession>
    <name>A0A0D2VJN0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364400.1">
        <property type="nucleotide sequence ID" value="XM_004364343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJN0"/>
    <dbReference type="InParanoid" id="A0A0D2VJN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="252" mass="27846" checksum="654E1D0948A62C76" modified="2015-04-29" version="1">MQYHSGHSAQYYSDISRIFAQLEWQLTNTAAAATATADDPYSSSGLLLEDGSGAAAFELPAGNDSAAYAQNTYAMQMVDEASALLSQAGQNGIVNDLPAYTRYGRSMAGIDTNRDAAQYILAQQAEQDEMWNSVSEEARMQAEGLLPPTQAVMQQRFAGAAAHPPPPLLQPTPDDASLRSTRKRGWEPSDETDQTDQQPRKRLADDVQDYSGSLQLLYEDNIPPAILQQQQELQLLHEQQQQQQEQHESQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL55</accession>
    <name>A0A0D2VL55_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="3">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ROX family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348829.1">
        <property type="nucleotide sequence ID" value="XM_004348779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL55"/>
    <dbReference type="eggNOG" id="KOG3706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253681" description="Bifunctional lysine-specific demethylase and histidyl-hydroxylase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="259"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="879" mass="97782" checksum="1AACDF0BDFDC9BFA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLB8</accession>
    <name>A0A0D2VLB8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CEMIP beta-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270183.1">
        <property type="nucleotide sequence ID" value="XM_011271881.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLB8"/>
    <dbReference type="eggNOG" id="ENOG502QT0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLB8"/>
    <dbReference type="OrthoDB" id="190675at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253683" description="CEMIP beta-helix domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="domain" description="CEMIP beta-helix" evidence="3">
        <location>
            <begin position="390"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1722" mass="185184" checksum="515683721E98FF4E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM56</accession>
    <name>A0A0D2VM56_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349123.1">
        <property type="nucleotide sequence ID" value="XM_004349073.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM56"/>
    <dbReference type="FunCoup" id="A0A0D2VM56">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VM56"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM56"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM56"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="298" mass="32741" checksum="6C859CC7A1E32C3B" modified="2015-04-29" version="1">MASTSAAASSASTTTTGTAPRDDELTAALAELKGIAQRDAALSPEVQLARLTNEATKHTSLLNPYEVLQLPFEASESDIKKTYRALSLLVHPDKHADNPQAHEAFEVVNKAYKSLTDPEQATKLKIIVSEAKLMAAEELKRRRKPPTAASAQQQHQILSSGVAILPGEADEVILDKMARAHATLLFVDLDRKRKEHDAREALNKKRARELELEMEESRKKLLLSKQAMDDSRDDRVASWRTFVETGKKSGKTSTGAAKSVSKGFGRGMRPPKLQPEARTEFSLRQQQASDQLHGGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM95</accession>
    <name>A0A0D2VM95_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349177.1">
        <property type="nucleotide sequence ID" value="XM_004349127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM95"/>
    <dbReference type="FunCoup" id="A0A0D2VM95">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VM95"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM95"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM95"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="26191" checksum="FF355648B12EF426" modified="2015-04-29" version="1">MSSITGLQGSASAAIAAIQQSNAQVQPELMQEVKLYTTAKERELYDNMADLFAIIQTLNYLEKAYVRDSISPSEYTPACEKLIAQFRTAKSMLKDQVPSIEKFMGDYKLSCPAAYQRLQIGVPATVEHGGTGESTSARNAAVHVAETVQSFITLMDSIKLQMSAVDELHPQLNDLLGSMNKLPSLSADWEGKVNLREWLAKMNAMQASDELTPEQLRQLLFDLEKHHNAFYRSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VP51</accession>
    <name>A0A0D2VP51_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364028.2">
        <property type="nucleotide sequence ID" value="XM_004363971.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VP51"/>
    <dbReference type="STRING" id="595528.A0A0D2VP51"/>
    <dbReference type="eggNOG" id="KOG2223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VP51"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VP51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="266"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="586" mass="63548" checksum="EB6AE2FBD3118333" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPS3</accession>
    <name>A0A0D2VPS3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348379.2">
        <property type="nucleotide sequence ID" value="XM_004348329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPS3"/>
    <dbReference type="eggNOG" id="ENOG502RZ7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPS3"/>
    <dbReference type="OrthoDB" id="2093442at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="421" mass="45444" checksum="CF15796D0DFCDFE8" modified="2015-04-29" version="1">MNQSEATALIVQQQQQSPQTARAMMSRRTRVVLGAILAIGLVCGAVALAVSMSSSSASSSSEAQGRRTGATYPVACPAAPANPEDRRTDKSRLRVASFNAEWLFLGQLAPTGARESGTDDKRSSQSSDSDVHRRGAISCPGDCTWTTPQEAVQHFDRVVKVLKDVNADIINLVEIENCTILYYLVNALPGFGYKPYLITGTDTATGQNVGILTRVDPYMAMTRDESRQNYPVPGTQCAAATASGTTGVSKHYLTAFQINNKKVGMMGLHLLSQPWQAENCRKREAQALVARNAADTILAGVDELIFLGDFNDYDGTVLDIAGSVPTSRTLEYLKTPINPSTAHLALSNVASHVPLENRYTSWWDKDNSCVDEGGDEHTSIDHMLVSAGLAAGIQNVLFDHEFVACCQCVSDHWPVVVDFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ61</accession>
    <name>A0A0D2VQ61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270350.1">
        <property type="nucleotide sequence ID" value="XM_011272048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ61"/>
    <dbReference type="FunCoup" id="A0A0D2VQ61">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQ61"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ61"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="13">
        <location>
            <begin position="146"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="11">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="11">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="11">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122801" checksum="0F8FE2BB785AAD3F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ87</accession>
    <name>A0A0D2VQ87_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363400.1">
        <property type="nucleotide sequence ID" value="XM_004363343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ87"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ87"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ87"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ87"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="280" mass="28940" checksum="DBBFE2B3449FED0C" modified="2015-04-29" version="1">MSLSPATILAADADARRAIVAGDHSACKVALLVDHTQLKQECTTAHIVALCAQAREHDFRSVCIPPSRVALARSLLVLPAQLSKADAAGAAVRVCTVVGFPNGYMTTAAKVAETADAVAAGADEIDFVQNVGWVKDANWTDTRNEYRAIVAAAGPARLVKVILETALLTPDEIERCSTIAVQAGIHTVKTSTGFAARGASLADVEAMQRGIELAFADGSTPRRVVGIKASGGIRDTVTALQFIRAGATRLGTSSGVAIISGLQHHQPGESSGAAASTSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQC4</accession>
    <name>A0A0D2VQC4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363462.1">
        <property type="nucleotide sequence ID" value="XM_004363405.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQC4"/>
    <dbReference type="STRING" id="595528.A0A0D2VQC4"/>
    <dbReference type="eggNOG" id="KOG2567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQC4"/>
    <dbReference type="OMA" id="VCFLTIT"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQC4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="187" mass="19656" checksum="1293D5E12874EB14" modified="2015-04-29" version="1">MSVANYKRTVQAQPLVPNSASNAAVLAPHVRSVARTQVFAPSSSASSSTDPATSTTAASEAAASASTTSSGVADLPVNHVRITPHGSMKGFISYALRQLEETEATEIVLHAIGAAVNRGISVAEIVKRKYPGLHQNTQIFYTKTVEVWEPTVPGLDKLKASRNQPTIQIVLSKAPLDPSAPGYQAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQZ7</accession>
    <name>A0A0D2VQZ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347891.1">
        <property type="nucleotide sequence ID" value="XM_004347841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQZ7"/>
    <dbReference type="STRING" id="595528.A0A0D2VQZ7"/>
    <dbReference type="eggNOG" id="KOG0702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQZ7"/>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQZ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="216"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37876" checksum="7BABD02DD6A9D8A2" modified="2015-04-29" version="1">MVLSEDERHLKELRLMLADPKNRNCCECGALYPQYANVMNGTFVCERCSDVLRDLSQRTKPVNTATFSATEVELLRTRGNRSAYKVWMGNWNPTEHPVPDAADTPRFRQFLRLKYIERKFYDPEAERTVDEYGGVGSVFANGKKTRIVSAPPQNSNTRRSWYEGITNRLRPSSSASQQARSLQYADNSRSERSSVSYSVAEVEDNASLGSNGTGDIPTLTWSAKVVDNVRKEDGAQAFVIDVATSLGGQHSVKRTYDEFFDFQCALLDHFPVEAGTTGQKRVIPYLPGKKVFMTARVLLERQKELNEYVQELSLLPEELRSWEKFQDFFCFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR31</accession>
    <name>A0A0D2VR31_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347928.1">
        <property type="nucleotide sequence ID" value="XM_004347878.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR31"/>
    <dbReference type="InParanoid" id="A0A0D2VR31"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="entry name" value="AF2212/PG0164-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141694">
        <property type="entry name" value="AF2212/PG0164-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20099" checksum="15CC56E236295502" modified="2015-04-29" version="1">MPPVSFRAPLRRPANNPSQSEPWWFVVLPTESSASLPRRGRTTVTGTINGRAPFQATLEPDGQLSHWLKLNDELRRAAGAEEGDTVAVELRPVETEPEPQIPDDLAAALAAAPQAARDAWNQTTTIARVDWIHWMTSAKQPRTRTKRVADACDKLASGKKRVCCFDPSGHYSKAFCAPEAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRC9</accession>
    <name>A0A0D2VRC9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRC9"/>
    <dbReference type="InParanoid" id="A0A0D2VRC9"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038801">
        <property type="entry name" value="TAF1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1160" mass="123477" checksum="7F2BD3E3BA41F04E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VT60</accession>
    <name>A0A0D2VT60_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346740.1">
        <property type="nucleotide sequence ID" value="XM_004346690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VT60"/>
    <dbReference type="FunCoup" id="A0A0D2VT60">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VT60"/>
    <dbReference type="OMA" id="ETHFAFY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VT60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="200" mass="21908" checksum="800D8A5754F9A1C1" modified="2015-04-29" version="1">MSRPTAGLFDLRGQIGFYAQYHHNTWNKLIHIVCVPLLLWTPMIWLARTGAIAALPAGVQSFAAGFGLNPVFDGAMVLALFYGTYYAILEPVAGTVAAGILLAGAYSATYVSFNVDNVINLSIGLHVVCWIAQFIGHGVAEKRAPALFQSLFQSLVLAPLFVWLEVLFAFGYRKSLAKEINIQAIKDIKTFRDSQKNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTV6</accession>
    <name>A0A0D2VTV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347030.2">
        <property type="nucleotide sequence ID" value="XM_004346980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTV6"/>
    <dbReference type="STRING" id="595528.A0A0D2VTV6"/>
    <dbReference type="eggNOG" id="KOG1277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTV6"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354333" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="596" mass="67882" checksum="ADC3FA799F5F2F69" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWH4</accession>
    <name>A0A0D2VWH4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345070.1">
        <property type="nucleotide sequence ID" value="XM_004345020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWH4"/>
    <dbReference type="STRING" id="595528.A0A0D2VWH4"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWH4"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWH4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="93" mass="9733" checksum="FC463C51A88FFCE6" modified="2015-04-29" version="1">MDLPGLGQFYCVACARYFIDELSLNVHFKSKVHRRRLKELKEPAYTQEDAEAAAGMSTTLTSRSNAAGASGSGTTSTAASSSAPAPTATSMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYI6</accession>
    <name>A0A0D2VYI6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343780.1">
        <property type="nucleotide sequence ID" value="XM_004343730.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYI6"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYI6"/>
    <dbReference type="OMA" id="NEACSIN"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYI6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="283"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="737"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="889"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1248"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1462" mass="155579" checksum="8E21DB4BCF0A3A7C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYU9</accession>
    <name>A0A0D2VYU9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343901.1">
        <property type="nucleotide sequence ID" value="XM_004343851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYU9"/>
    <dbReference type="FunCoup" id="A0A0D2VYU9">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VYU9"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VYU9"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="63185at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VYU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="136" mass="15408" checksum="E30D29656A8A288A" modified="2015-04-29" version="1">MARTKQTARKSTGGKAPRKQLATKAARKTAVTSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAVHALQEAAEAYLVGLFEDSNLCAIHARRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZ29</accession>
    <name>A0A0D2VZ29_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343387.1">
        <property type="nucleotide sequence ID" value="XM_004343337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZ29"/>
    <dbReference type="InParanoid" id="A0A0D2VZ29"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZ29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="902" mass="98829" checksum="4C966C3E203B38DB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W094</accession>
    <name>A0A0D2W094_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343281.1">
        <property type="nucleotide sequence ID" value="XM_004343231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W094"/>
    <dbReference type="FunCoup" id="A0A0D2W094">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W094"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W094"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W094"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="186" mass="21179" checksum="E82E4C5303DFBFC4" modified="2015-04-29" version="1">MKQQPQHLFNSDVLVDLEKEQPADEKVAFTTGVSPSNPGANLLLRPLARDDYEKGFLQLLAQLTTVGEYPKEQFEERFEEMRALKDTYYVCVLEDTTTGKIIATGTLVVERKFIRGAAKRGHIEDIVVDSNTRGKQLGKLIIQTLRLLAKRTGCYKVTLDCSTTNVPFYEKCDFSKEDIHLMTKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0Q2</accession>
    <name>A0A0D2W0Q2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_007911</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342996.1">
        <property type="nucleotide sequence ID" value="XM_004342946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0Q2"/>
    <dbReference type="STRING" id="595528.A0A0D2W0Q2"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0Q2"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0Q2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="172"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="284"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE97817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="431" mass="46575" checksum="E3C7011E3400B8B3" modified="2015-04-29" version="1">MASLTIARRIASASLGASSARTFASAATTASLAGGPGPAKFVKFNHTDPLNMDGLLTEEERMVRDMANEYCQSKLLPRVKLAYRHETFDRAIFTEMGKLGMLGATIQGYECPGVSSVAYGLIAREVERVDSSYRSAMSVQSSLVMYPIYAYGTEAQRKKYLPGLARGELVGCFGLTEPNHGSDPGSMETRARKTPQGNYILNGAKMWITNSPIADVFVVWAKTVEDGIIRGFVLEKGMKGLSAPKIEGKFSLRASPTGEIVMQDVEVPAENLLPNVEGLKGPFGCLTNARYGISFGAMGAAEFCMEAARTYTVDRKQFGRPLASNQLIQKKLADMLTEINLGLLASLQVGRLKDAGKLAPEMVSLVKRNNCGKALDIARVARDMLGGNGISDEYGVIRHVLNLEAVNTYEGTHDIHALILGRAMTGLQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1B4</accession>
    <name>A0A0D2W1B4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342693.2">
        <property type="nucleotide sequence ID" value="XM_004342644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1B4"/>
    <dbReference type="STRING" id="595528.A0A0D2W1B4"/>
    <dbReference type="eggNOG" id="KOG3668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1B4"/>
    <dbReference type="OrthoDB" id="10053061at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1B4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF54">
        <property type="entry name" value="CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="264" mass="30571" checksum="25AA7DA6A36D8D5B" modified="2015-04-29" version="1">MLEREYRILVPMTVDEYRIGQIYMTVRHTEKETQAGTEVEVVVNEAREHPELGPGHYTEKRYYLASKFPGWLAAIVPSNMYLCEKSWNCYPKTLTETTASFCSSFYLRIETLYTSPTPTEEAHQPSPLPIDVVDIVRDDYPKSHYLEAEDPHYFTSIKTGRGPLREGWCSDPVIPKMLAIKRVSASFAFWGLQTKVESFTHQCLREIFLVGHRQAFAWIDEWIELSEADVREYEEQVLACATRSHQSTAETHQHHHTAPDSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W241</accession>
    <name>A0A0D2W241_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer kinetochore protein DAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008372</name>
        <name evidence="1" type="ORF">CAOG_010092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346426">
        <property type="protein sequence ID" value="KJE98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004340388.1">
        <property type="nucleotide sequence ID" value="XM_004340340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W241"/>
    <dbReference type="InParanoid" id="A0A0D2W241"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8470" checksum="47CF8C80D00B8ADE" modified="2015-04-29" version="1">MSTHFEQTKRHLIGEIAQSLSETADLTGAVASNVDALLASGQDVTALAAAWTTFQRTLALSTASLGAAARSLAHSEPMDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGF5</accession>
    <name>A0A0D2WGF5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Atypical/ABC1/ABC1-D protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGF5"/>
    <dbReference type="STRING" id="595528.A0A0D2WGF5"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGF5"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGF5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254351" evidence="3">
        <location>
            <begin position="26"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="258"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="724" mass="79868" checksum="0EDA6DC799DF239D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHZ0</accession>
    <name>A0A0D2WHZ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WHZ0">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHZ0"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHZ0"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="7">
        <location>
            <begin position="945"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1413"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1423"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1549"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1596" mass="173400" checksum="7FAFE0F2E90CBDA3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI49</accession>
    <name>A0A0D2WI49_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="8">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365807.1">
        <property type="nucleotide sequence ID" value="XM_004365750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI49"/>
    <dbReference type="FunCoup" id="A0A0D2WI49">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WI49"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI49"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI49"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113005" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="8">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="292"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="438" mass="48672" checksum="8A35861022D9E19E" modified="2015-04-29" version="1">MRIVPVLLALTAVLALTSLSRAAPRVPGKTLVLLENYSLRQTHSTFFRQLQEQDFTLSFALADEKKLSLSSYGDRIYDNLIIFAPSAEEFGGSLTVRSILDFVDHGGNVIVAGSSSIGEPIREFGSECGFEFDEESAAVIDHINFDSKLDNGEHTTIVTDQIIDNKLIAGTNKGRVLFRGVGLVQDLSNPLTIRVLSAESTAYTYFTDEKISVAPHVVGSKTVLVGALQARNNARVLFSGSLDLFSDEFFNAQVNVAGATASPSANRDFAISAALWTFKRSGILRVSGEPKHHLAGQTTVPELYTVFDQIEYSLRVEELVDRNWVGYQGNDMQLEFVMLNPYLRLTLNNTGDGVQHASFQAPDVYGVFQFRVDYKRTGYTYVQVHNQIPVRPLQNTQYERFIFSAFPYYASAFSMMGGLFVFSLVFLYHREAPATKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WID7</accession>
    <name>A0A0D2WID7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365214.1">
        <property type="nucleotide sequence ID" value="XM_004365157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WID7"/>
    <dbReference type="InParanoid" id="A0A0D2WID7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="17966" checksum="9BD87597B6CDD2CC" modified="2015-04-29" version="1">MQYTDGNEDSAYDASSAYSNWSDRSKRVRRHDDGDDGSGDGDLPQSIKKPRAFLLLQPSAFTFQSVEHKPNGQSMYSALDSEIFINLKRVDQISFSGLAEQFFISENNRVVRAETGQLVFLWRSNADGRLAISQSFAFTNNSEFLFYRSELDRLIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJZ7</accession>
    <name>A0A0D2WJZ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349777.2">
        <property type="nucleotide sequence ID" value="XM_004349727.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJZ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WJZ7"/>
    <dbReference type="eggNOG" id="ENOG502QTV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJZ7"/>
    <dbReference type="OrthoDB" id="79762at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="706" mass="74682" checksum="3396E572A657C8B2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKG7</accession>
    <name>A0A0D2WKG7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-nitrophenylphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKG7"/>
    <dbReference type="FunCoup" id="A0A0D2WKG7">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKG7"/>
    <dbReference type="InParanoid" id="A0A0D2WKG7"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35947" checksum="C83E5AEFAADE7868" modified="2015-04-29" version="1">MSATPVPQLGDFKAYIASIDTFILDCDGVIWQADKLIPGVKETLQALKQAGKRVVFLTNNSSKSRAMYVAKFTSLGLDVSVNDIFGSSFAAADYLRQIKFDKKAYVLGAQGLLDELTSVGVQYVGGYKEDTVNPWTSIDQGYVEDNPEIGAVVVGFDPAINYFKLARAYTYIQQPGCLFIATNHDSTFPAKGGRLLPGTGTIVSALEVAHGSNALVMGKPSHFMLDCVKTAIGYDPARTVMVGDRYKHPFCFFGIMCRFCYILLTSNNPSLLHACCSLDTDIQFGLNGNLHTLLVLTGVTSLETLQSTSNAIRPEFYTPSFADLHAGLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKM4</accession>
    <name>A0A0D2WKM4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348855.1">
        <property type="nucleotide sequence ID" value="XM_004348805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKM4"/>
    <dbReference type="FunCoup" id="A0A0D2WKM4">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKM4"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKM4"/>
    <dbReference type="OMA" id="HDAKSWE"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKM4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000005">
        <property type="entry name" value="TatD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="393" mass="41146" checksum="163A0B59E51BCB44" modified="2015-04-29" version="1">MSAIRTFSEAASAAVSPASLASTAAAAAASVVAASASASSSPAAASVVAASASSPGAGTGATGHRAPRAPKQPKAAVDAGAAPNKRSPKPAASGSSSSSSGASGASGSGAAPKKSVLLPSPLPIADIGINLAHDHFARDVEHFLRRAAEVNVTTMVITGTSMRGSVEALELARRHGMHATVGVHPHDAKSCTTGTIPKMRQLFTSADTASLAVAVGECGLDFDRNFSPQDVQMKWFEEQLKLAVELKKPVFLHERSAHEAFVRILEPYMPQLTGAVVHCFTGTDAELKKYLSMGCHIGITGWICDERRGTDLAKIVHQIPLDRLMIETDAPYLIPRNIRPRQSQNEPAFLPYVLEMVAQCMGKSVEEVARGTFETTRRFFQLPESALPAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKR9</accession>
    <name>A0A0D2WKR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364471.2">
        <property type="nucleotide sequence ID" value="XM_004364414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKR9"/>
    <dbReference type="STRING" id="595528.A0A0D2WKR9"/>
    <dbReference type="InParanoid" id="A0A0D2WKR9"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="404" mass="42195" checksum="7F65D55B3A029FB7" modified="2015-04-29" version="1">MSTRPKLVALKDLSATRSDAGASSGSSGSSNRMPSSFAAVAGGSGSSSPSVGATSSSSATGSSSADQSSTASGASSTTSGWMSAGGLKTVISTSSSSASHPASAEEGGDEWLDQTATTTDGAGSSSSPSTTGSSAASSNYSSRQRSDDGPRRNQSERSSVPPDSYTCNLCKIPGHWMENCEMYKPPASRSQHYGDRNSNSNSNSSWGNSGNNRSVPPESYRCRLCNVGGHYIQDCHLSTNSGGAGGDRQSGGGGFGRPSQSTDWRASGDGAGSSNSFSRQNNHNNNNNNRSFQQPGFGSFGNNRGNSYQQQHHNDQRNPPPASYTCRLCQTPGHWLENCHKFKRGNDSFSDDRRRNNQGGSRGPSRGTGGPVPANYVCRLCNTAGHWIQDCELSGQQRTSEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKY6</accession>
    <name>A0A0D2WKY6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_001714</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364582.2">
        <property type="nucleotide sequence ID" value="XM_004364525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKY6"/>
    <dbReference type="STRING" id="595528.A0A0D2WKY6"/>
    <dbReference type="eggNOG" id="KOG2966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKY6"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKY6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="308" mass="33372" checksum="0D70F68DA828ABA9" modified="2015-04-29" version="1">MVFAAGSLTRLSQIVLRAPVSAAAPTVRRFASFVPVAASADSANKVSVVNGIPMLRLAIGAHPVTAFTLVPGTTIGSLAKNIADELGAKDPIQVALADGTPFSSSSDVRILTKTPFKVVSGQRQADISVSEATTAAALHSDKLNPELASAIKRMQHVLDVDKEIEDKKIELATTIGNISSELAPLQKVKDELDVKAAAHTNRLAWFGLAAMSFQFGVLAQLTWFEYSWDIVEPITYFVTYSAVIGAYAYYVLTKSNYEFTGVQERKWLQFLHSQGPKRGLDIQRYNHLRDSLAAAEAKLAQLKTIHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLM9</accession>
    <name>A0A0D2WLM9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLM9"/>
    <dbReference type="eggNOG" id="KOG1025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLM9"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000027">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="408"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1353" mass="148177" checksum="746459E23386C2F4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLR6</accession>
    <name>A0A0D2WLR6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Methionine synthase</fullName>
            <ecNumber evidence="5 16">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CAOG_002686</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16 17">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5 16"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349436.1">
        <property type="nucleotide sequence ID" value="XM_004349386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLR6"/>
    <dbReference type="STRING" id="595528.A0A0D2WLR6"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLR6"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLR6"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00740">
        <property type="entry name" value="MeTr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.10:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000002">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.288.10">
        <property type="entry name" value="Cobalamin-dependent Methionine Synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="entry name" value="Vitamin B12-dependent methionine synthase, activation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007024">
        <property type="entry name" value="PRK09490.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="Methionine synthase activation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 16 17" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="15 16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 16 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 16 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="21">
        <location>
            <begin position="16"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="22">
        <location>
            <begin position="371"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="25">
        <location>
            <begin position="664"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="24">
        <location>
            <begin position="774"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="23">
        <location>
            <begin position="925"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="784"/>
            <end position="788"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="976"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJE91560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139534" checksum="3212E8FA2648791D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLX1</accession>
    <name>A0A0D2WLX1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349529.2">
        <property type="nucleotide sequence ID" value="XM_004349479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLX1"/>
    <dbReference type="FunCoup" id="A0A0D2WLX1">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLX1"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLX1"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="29832" checksum="E07624F95DC93B51" modified="2015-04-29" version="1">MPQNEYIEQARKRHGYRMDHFERLRKREAREGHNRSEYAQNVTGLKAKLYNKKRHTEKIEMKKTIKMHQERSNKQKDDSAVPQGAVPAYLLDREGQSRAKVLSNMVKQKRKEKAGKWDVPLPKVRGIGESEVFRVVKTGKRKIKGWKRMVTKATFVGEGFTRKPPKYERFIRPMGLRFKKAHVTHPELSATFCLPIVGVKKNPQSPLYTQLGVITKGTIIEVNVSELGLVTQNGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM37</accession>
    <name>A0A0D2WM37_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monofunctional lysine-ketoglutarate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363749.2">
        <property type="nucleotide sequence ID" value="XM_004363692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM37"/>
    <dbReference type="STRING" id="595528.A0A0D2WM37"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WM37"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM37"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2690">
        <property type="entry name" value="LOR/SDH bifunctional enzyme, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043009">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="3">
        <location>
            <begin position="190"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="600" mass="66631" checksum="29C558258811D2F2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMD4</accession>
    <name>A0A0D2WMD4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270206.1">
        <property type="nucleotide sequence ID" value="XM_011271904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMD4"/>
    <dbReference type="eggNOG" id="ENOG502RZ1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMD4"/>
    <dbReference type="OMA" id="WELWSIS"/>
    <dbReference type="OrthoDB" id="58903at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMD4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="187" mass="21086" checksum="415F44697A2F6416" modified="2015-04-29" version="1">MTERRRRAGDLDESTERLLQNDDDSNHGHSHSHGHGHSHANPVSLREPSHRRHDPLGALPPASPGHPTIEGVVWFGLALLIYRFTNFPEVIMFDSRIRRSYLHFGLALMGVNVLISLYLVVYLRWIRKSQAAWEVEAPYAIPIITACGVLAAVLLSIAIWPVWGILSPFFLFVLLMGLVVVLRLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMW8</accession>
    <name>A0A0D2WMW8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMW8"/>
    <dbReference type="InParanoid" id="A0A0D2WMW8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="26631" checksum="0DB3EBF7562D4130" modified="2015-04-29" version="1">MGNGKWGERERDSGRAARTRGIVRMLRWIWSSTLRSVEGDRQTSCGLSSSLPIHPFVKVCRNSPLPSPERWKQTRSTIHFRKFAASHRVNATVLHPHFWSSTFTNSPPPLLCPYLQCLFNRLLWVWLGLRCESFCVLVMPCATALHKNGRNIKKIKNKNKKNKKPTTTKLKKKKALFGLVLSRWLRLPRMSPVCLSINVLSPISLSHYLCFNCLTLSSWFPSRFRSLQVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN92</accession>
    <name>A0A0D2WN92_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363743.2">
        <property type="nucleotide sequence ID" value="XM_004363686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN92"/>
    <dbReference type="STRING" id="595528.A0A0D2WN92"/>
    <dbReference type="eggNOG" id="KOG4423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN92"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002133">
        <property type="entry name" value="Ras family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="228" mass="25397" checksum="E13727569C89826E" modified="2015-04-29" version="1">MEGAAGPTADQLFKIIVIGDYAVGKTSLIRRYSEGFFTPNYKLTIGADFATKVLEWESGAKITLQLWDIAGHERFGHMTHVYYKYAIAAVIVFDMTRPATFDSVIKWLNDVNNKVMLPDGKPVPVMLLANKADMSDKSVYKQKLDDFCKEHGLIGWFATSAKNNANIDQAMNFLVGSVIQISKRAPAELVKSPIEEFVRLSGNDIPTREQRQANNANDPMKQLGQCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNB3</accession>
    <name>A0A0D2WNB3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNB3"/>
    <dbReference type="STRING" id="595528.A0A0D2WNB3"/>
    <dbReference type="eggNOG" id="KOG3521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNB3"/>
    <dbReference type="OrthoDB" id="5585231at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNB3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="462"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="715"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116779" checksum="C8820D3DC8F0EE5F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WND3</accession>
    <name>A0A0D2WND3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348422.1">
        <property type="nucleotide sequence ID" value="XM_004348372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WND3"/>
    <dbReference type="FunCoup" id="A0A0D2WND3">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WND3"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WND3"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WND3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="448" mass="49615" checksum="E637CE676A5130D7" modified="2015-04-29" version="1">MGREIVHIQTGQCGNQIGTKFWEVISGEHGLDGTGTYVGDNPLQLERSDVYFNESGNGRYVPRAVLVDLEPGTMDAIRGGPLGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIEPILDVVRKEAEGCDSLQGFQITHSLGGGTGSGLGTLLISKIHEEFPDRILTSYSVVPSPKVSDAVVEPYNATLSIHQLVENTDMTFCIDNEALYEICFNTLKLTTPNYADLNHLVSNTMSGVTTCLRFPGQLNADLRKLAVNLVPFPRLHFFMPGFAPLTARNVQSFRNVTVAELTQQMFNAKNMMAACDPRHGRYLTVAAMFRGKISMKDVDDQMLAIQNKNSSYFVDWIPNNVKTAVCDVPPKGLNMSATFIGNNTAIQQLFKRVSEQFTAMFRRKAFLHWYTSEGMDEMEFTEAESNLNDLVSEYQQYQEATAEDDHVEGEQDASAIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNM4</accession>
    <name>A0A0D2WNM4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNM4"/>
    <dbReference type="InParanoid" id="A0A0D2WNM4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="121" mass="13699" checksum="0B4FDB29E5C12CF6" modified="2015-04-29" version="1">MCFLFSPSPRFSPLLPASPLLPFQLPSPSFTPSPLHSAAALYRDSACFFAVPFHSWNVVHFVLPLFRHFVHPPASAFESKDCDKSSILQCNVANMHPNPLENKTKKGNKRIKKHREKKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNM8</accession>
    <name>A0A0D2WNM8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363408.1">
        <property type="nucleotide sequence ID" value="XM_004363351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNM8"/>
    <dbReference type="InParanoid" id="A0A0D2WNM8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="Csp_YhjQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="Csp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="203" mass="21354" checksum="78788DD806FA7021" modified="2015-04-29" version="1">MTAHDIADCLASLAECRSLCLQTVVDCLKHGGLLASLPHIRAMNDCTELCGTTSALLLRESPLAGHLCAMTSEACQLCVIDLKAFGDNMTPMMRNVVAVCQKTQTRTLALFRFTQSAAAAARSQTQLQEYDPHHHGNAIPGAVPGATPSAPPTNLAPPAIPAKSVQSPPQAKILSPEPAVASIGSPKRDKRTSEAMATGMRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP34</accession>
    <name>A0A0D2WP34_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364163.2">
        <property type="nucleotide sequence ID" value="XM_004364106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP34"/>
    <dbReference type="FunCoup" id="A0A0D2WP34">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WP34"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP34"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP34"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="307"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="429"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="550" mass="59395" checksum="4B4F450AD2647ACE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPH5</accession>
    <name>A0A0D2WPH5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348408.1">
        <property type="nucleotide sequence ID" value="XM_004348358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPH5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPH5"/>
    <dbReference type="eggNOG" id="ENOG502QSAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPH5"/>
    <dbReference type="OMA" id="VWGFADT"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="395" mass="42918" checksum="4BF5C5D4D513A80B" modified="2015-04-29" version="1">MTTLGLSALPRPGALRFAAQAPPLDKDALVHRILSEHPLNHAVELVLPWARDRAISANAKQTNAADSVTRMSVAQPLKSAEFHVIEIPLLALLDTEFLQRHVRNGHFVAMSVSERLDGSTCVPAVADGFLTLSLSKEAYELCGLEGQLSKHEIQQRHTVRIHLAAESFVPGKSHYERVKWCFAERLTRSFKFVCTDAATYTNGDQPAPSPAHALNKHALAPARTLHLSHTEQRAVTVPQLLVAPIESVAAQDNATLGPYLSTWQTWFGAISCGISLAPRAADDFASTFQFEGVEVEISDTGDAVPLAVSISKFTGIVSSEQIKRVVARARAYLATCPELPWAALNIWGFIDAPVAYGDREHCLEQANGENDVTLILFRDGGSCVLSTASSRNELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPX9</accession>
    <name>A0A0D2WPX9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003768</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363496.1">
        <property type="nucleotide sequence ID" value="XM_004363439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPX9"/>
    <dbReference type="STRING" id="595528.A0A0D2WPX9"/>
    <dbReference type="InParanoid" id="A0A0D2WPX9"/>
    <dbReference type="OrthoDB" id="5571606at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPX9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="15017" checksum="74E0A9F04236040E" modified="2015-04-29" version="1">MFALRRVPALLAAASTSTPAPPAAAVRLSARSLSSQVPAARGGGGHGHGHGHGRPLDPAREYPNGFLFNEKPGPRAKWQDWEPAWYIGMIGGLVLFGVVTYYRPDTDPTVKARAIALERLREQNPDAVHEESEAAAPAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQI1</accession>
    <name>A0A0D2WQI1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347829.1">
        <property type="nucleotide sequence ID" value="XM_004347779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQI1"/>
    <dbReference type="STRING" id="595528.A0A0D2WQI1"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQI1"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="192" mass="21227" checksum="CE21B5945606714D" modified="2015-04-29" version="1">MALIPRVARESTAFLLCDIQERFRNSIVHFPSVIHVATTMTQAAGILNVPLIVTEHVPQVFGKTLSEISAVYPRNTNIFSKTKFSMATPEVASFLTAGKFRSVVLFGIEAHVCLQQTALDLVSAGYGVHVLADGSSSSRQFERTIAFDRLRQVGVTITSSESMLFELMQDAKYENFKSILELVKRTRPDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQK6</accession>
    <name>A0A0D2WQK6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347879.2">
        <property type="nucleotide sequence ID" value="XM_004347829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQK6"/>
    <dbReference type="STRING" id="595528.A0A0D2WQK6"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQK6"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQK6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="144"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="301" mass="32842" checksum="4F7A4407F18535D5" modified="2015-04-29" version="1">MSDGDLAPMDIAPAVVASTGPKSTGTSAAAASAQRMRPQLSSASLNKLPSDVDEASVASRAGSTASSAWTATTGYTSATRAASTVAPIKRTVATTAVTAPVRASQRTATGTSKHRPSEDDLSTMTGGPTQRRWNSSHMYFPYILMGYVQLAFNTAIIIIMLYFAYQVVSTIQHDIDIKVDDYAQAITKEIELCSKHFLENKCAPHTRIPAIERSCIEWEKCIQRDPATMGRAKITAEIFAEIVNSFIEPISYKTMAFFVAFFFGFTIVGNYAFHFARSRVPEPPQFKQPAYMALAPQHGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQS7</accession>
    <name>A0A0D2WQS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270392.1">
        <property type="nucleotide sequence ID" value="XM_011272090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQS7"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQS7"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="371"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="696" mass="74014" checksum="ECA606DD32706F13" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQT3</accession>
    <name>A0A0D2WQT3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQT3"/>
    <dbReference type="InParanoid" id="A0A0D2WQT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="128" mass="13536" checksum="BC4664650FBB44DB" modified="2015-04-29" version="1">MYLLKEVHSVSQNGTGYTARWSSSGVPSAFRAFRHCEPSSLCSQTRIATIDFWRSSGATPDSEISKFELSELCASLSDSKSLSGCSGAGCPAASTRSSHDMRTCSSNYRHSEAGEGAYDGSDATSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR79</accession>
    <name>A0A0D2WR79_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR79"/>
    <dbReference type="STRING" id="595528.A0A0D2WR79"/>
    <dbReference type="eggNOG" id="KOG1608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WR79"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR79"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="406" mass="44033" checksum="D5DE4FE976258AE8" modified="2015-04-29" version="1">MHCLSMKNQLSGAGPASAGAAAPNAAAAANATSTAGGADAADAPKAPFSLADAYLNNHADVHMSFCLLAVIGYMNNYTADFVAPFVVASYDHPVKRDLGHVTVDVTEYGTGPLDLALLLFLVCFWLSVRAIVQEFILDKFILRLKFSSIRTHELFESAFRIFFYGIVVFWSWSIIRDNSYITNSASLTAGFPHLLMDLSTKLLLLSSIAFWLHNIPWQWIVEARPEQIRTRVIYSLINAAFVAAAYYLHYSRVSVCLLGAQAVSELLYSFYQLFEQAKKEDLARKSFQAWAVVFVFVRQAIITLLFKVFWSSTAVAAVPEPASAEGATDAQTVAVDEPQGAGLAGLVFAGAILAVQGVAIYQFIALMLTHKHGLSSLLSGKPKAAKQSDAAASNSSEASKKAKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRV2</accession>
    <name>A0A0D2WRV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRV2"/>
    <dbReference type="InParanoid" id="A0A0D2WRV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255192" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7290" checksum="FCFA0B3D0FDF8A6A" modified="2015-04-29" version="1">MAIVPCAYLSLLVLAIVLHPPRALAFFEKFATLVLRLSKGAQLTRNAPVPLTGRLGLSKNHACFMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTI0</accession>
    <name>A0A0D2WTI0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346172.1">
        <property type="nucleotide sequence ID" value="XM_004346122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTI0"/>
    <dbReference type="STRING" id="595528.A0A0D2WTI0"/>
    <dbReference type="eggNOG" id="ENOG502QW1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTI0"/>
    <dbReference type="OrthoDB" id="197892at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF83">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="4">
        <location>
            <begin position="248"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="3">
        <location>
            <begin position="525"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1150" mass="125981" checksum="3CD7DEC2D549E596" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTX7</accession>
    <name>A0A0D2WTX7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 DOCK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTX7"/>
    <dbReference type="STRING" id="595528.A0A0D2WTX7"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTX7"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTX7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="467"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="865" mass="94047" checksum="03309720BB160067" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUE1</accession>
    <name>A0A0D2WUE1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270686.1">
        <property type="nucleotide sequence ID" value="XM_011272384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUE1"/>
    <dbReference type="InParanoid" id="A0A0D2WUE1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="232" mass="24252" checksum="0F3CBF3C68165EC6" modified="2015-04-29" version="1">MSAQRARLICAPLVSNSTLFSSPPSASSPSTTASSSSPSSSTASAAAAAAASSFLTQWTAIVNDIVAQSSAMLNRRIAATASSSATVNEQVTAALETRALLAKLDKRCGDLTVAIQLLRRVDSQLAVLVDSDAAAAIASGAMLENAQSEPYVFPGCTLTRLALMVREVTAMFVRQYALVVSSVDLLQGTSDREQGTVILSAMLHQPYINEKTVTLLLGWIRDAITTESRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUJ8</accession>
    <name>A0A0D2WUJ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344336.1">
        <property type="nucleotide sequence ID" value="XM_004344286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUJ8"/>
    <dbReference type="STRING" id="595528.A0A0D2WUJ8"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUJ8"/>
    <dbReference type="OMA" id="TVQMSEN"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUJ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="37189" checksum="98EB441E83F9B8DD" modified="2015-04-29" version="1">MADGGSPSAALPEIDVDNIIERLLSVRGERPGKQVQLAEHEIRGLCLAARDIFIKQPILLELEAPIKICGDVHGQYFDLLRLFEYGGFPPDANYLFLGDYVDRGRQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLHSMEQIKKVMRPTDVPDTGLLCDLLWSDPEKDIQGWGENDRGVSFTFGPDVVSKFLQKHDIDLICRAHQVVEDGYEFFAKRQLVTVFSAPNYCGEFDNAGAMMSVDDTLMCSFHILKPADKKAADKKKAGKTSPKKALKKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUN3</accession>
    <name>A0A0D2WUN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="23">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_006751</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344372.2">
        <property type="nucleotide sequence ID" value="XM_004344322.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUN3"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUN3"/>
    <dbReference type="OrthoDB" id="5983152at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000017">
        <property type="entry name" value="Adhesion G protein-coupled receptor V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1295"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="22">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1417"/>
            <end position="1690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE96420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1706" mass="178093" checksum="1F5BD5EBDCD50670" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUU7</accession>
    <name>A0A0D2WUU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUU7"/>
    <dbReference type="STRING" id="595528.A0A0D2WUU7"/>
    <dbReference type="eggNOG" id="KOG1905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUU7"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUU7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097372">
        <property type="term" value="F:histone H3K18 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="46860" checksum="38D8307862901F80" modified="2015-04-29" version="1">MPACQIEVCTNCRPQRLHPREFDVTWLTKYKQHETGRLCTVCQQPLVDTIVHFKELGGERAPQVLNWSAAMRQAADADTIICLGSSLAVLQHYNDLWKRKKAVPLVANANSGNSQETSPADAQPASATLATATSPSAGTEPSQALSEVDAPPVANNTNVKSEATPELGSLTSDDPLPVDNPSSSSDGTPSEPQPGSSEPSSSQAEWSDSSTSASQASSSSLLPSERTTRRHRLAIVNLQWTPRDRYADIKIHARCDFVMAGLMQRLGLVASVYSRDKDPLFRTCIPLTAAEEALVWRDVQERLSEKRRHESESEAVAATESSLAAWQPNTEKSSSTNSLMLEYQTLQQLLAQPLLHDPSVISEAATRFQNVQLQLTALAPNPSSLGVGFLPQETGNTVSFGAAPGSSFLASAVVPLAPAWLGSTVSRKKPRLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW06</accession>
    <name>A0A0D2WW06_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW06"/>
    <dbReference type="eggNOG" id="KOG1056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW06"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW06"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="694"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1279" mass="138996" checksum="8607E4417AA71B23" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXJ9</accession>
    <name>A0A0D2WXJ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342612.1">
        <property type="nucleotide sequence ID" value="XM_004342563.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXJ9"/>
    <dbReference type="OMA" id="MYLATQF"/>
    <dbReference type="OrthoDB" id="10257571at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXJ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3949"/>
            <end position="3976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4020"/>
            <end position="4039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4059"/>
            <end position="4077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4083"/>
            <end position="4104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4140"/>
            <end position="4162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4174"/>
            <end position="4193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4205"/>
            <end position="4227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4239"/>
            <end position="4259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4287"/>
            <end position="4326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="4326" mass="457661" checksum="43F472730ABF5E32" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY01</accession>
    <name>A0A0D2WY01_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_008226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342481.1">
        <property type="nucleotide sequence ID" value="XM_004342432.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY01"/>
    <dbReference type="eggNOG" id="KOG0165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY01"/>
    <dbReference type="OMA" id="YSQKCCE"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY01"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21224">
        <property type="entry name" value="CH_ASPM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="580"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="733"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1684" mass="186692" checksum="22E6D32D2605C393" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYF4</accession>
    <name>A0A0D2WYF4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYF4"/>
    <dbReference type="STRING" id="595528.A0A0D2WYF4"/>
    <dbReference type="InParanoid" id="A0A0D2WYF4"/>
    <dbReference type="OrthoDB" id="1919692at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="600"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="821" mass="88173" checksum="18E4B7D917393BE0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0A5</accession>
    <name>A0A0D2X0A5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365185.1">
        <property type="nucleotide sequence ID" value="XM_004365128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0A5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0A5"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0A5"/>
    <dbReference type="OMA" id="QERVMYG"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0A5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="400" mass="44274" checksum="859B78B6A249B717" modified="2015-04-29" version="1">MPPKPSKNGKPADPRLAATVRTINDLKRSKPSWEELVKLCSKYHNALEVVTETARAFTAGMRAAASHAGKNSSLDVQRELYAIADIHDRLETHRTNVRQSLSEGFMIPIKRYIDAEMSTLQAWEKNYKAHFKYLNNEMTKAEEASKSAGKKNAAALQQAILDLTSRVKEIETARQSKLRELFLVEREKYCGLLLRYVEVVKSELKLHEDGFHSLGNGVSGWCDLASSKDSLPADSESLITAKERTFVGLKTEGGSPAPVPSHGGGYGGHAAPASYGGGEEYGNEQWDEEEVWDEELYDDNSGYNNQQQHQPQQSYGGGYHNAGIPAPPAPPPMGPKPGQPAQQQTWKVRALYDNVADDAQELSFRAGDIIEVTKQVNDEWWAGLCNGQHGIFPSNYCEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0F7</accession>
    <name>A0A0D2X0F7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0F7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0F7"/>
    <dbReference type="InParanoid" id="A0A0D2X0F7"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0F7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="732" mass="81206" checksum="7741FBD48D561392" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0P5</accession>
    <name>A0A0D2X0P5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365761.1">
        <property type="nucleotide sequence ID" value="XM_004365704.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0P5"/>
    <dbReference type="InParanoid" id="A0A0D2X0P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="810" mass="86927" checksum="BFFCF16FB94B73CD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0Y0</accession>
    <name>A0A0D2X0Y0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349789.2">
        <property type="nucleotide sequence ID" value="XM_004349739.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0Y0"/>
    <dbReference type="STRING" id="595528.A0A0D2X0Y0"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0Y0"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="662"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="861" mass="92317" checksum="DF75740B7253F938" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1F9</accession>
    <name>A0A0D2X1F9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364865.1">
        <property type="nucleotide sequence ID" value="XM_004364808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1F9"/>
    <dbReference type="STRING" id="595528.A0A0D2X1F9"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1F9"/>
    <dbReference type="OMA" id="GAGKQYK"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1F9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="276"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="608" mass="66016" checksum="7E0FF84DC9BA4840" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1H7</accession>
    <name>A0A0D2X1H7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1H7"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1H7"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1H7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="12">
        <location>
            <begin position="417"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1342"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1402" mass="154079" checksum="B88210768F0F2346" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1P4</accession>
    <name>A0A0D2X1P4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1P4"/>
    <dbReference type="FunCoup" id="A0A0D2X1P4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1P4"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1P4"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1P4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1020">
        <property type="entry name" value="RecQ-mediated genome instability protein 1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044881">
        <property type="entry name" value="RMI1_N_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="77"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="413" mass="43836" checksum="07F7E31F98EBB7C1" modified="2015-04-29" version="1">MQQESASVGAKLANQGIHVLSDWLSDCIAFLQQEAGPVDAQTLHGLVMEQWLSANLRDIGRGCLPELFASPDMLREVTSMVITHPLALQIEAITDVGDSAFRQIEGAGLFGASLTLNANDEDGPSHESDQTRANNPMYANSVAAAQGNHTRGMGAARLLVLKLSDGQRAVRAMTYRPIPTLTCDTLIGTKLLISNVTCRRGMLLLEPRNTKMLGGGLLTAEESKRRFFGILFRRIGQDPPPSLAARPAPPASSQASIALSQATRLTQPVPAAAAVASSTNPAALLRSAWPSSSTSAPSNSIRPQSTVATPLEHIDDDQDDSDDHLEITQPGRQTASWPSSHGRSTTATTPSAATAHQYSAAAHGDDDDFDNGFDVDFEDEAVSMSAPRAAPKRPAPVSETAGRSSKSMRIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y9</accession>
    <name>A0A0D2X1Y9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">endopeptidase La</fullName>
            <ecNumber evidence="7">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="7"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349499.2">
        <property type="nucleotide sequence ID" value="XM_004349449.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y9"/>
    <dbReference type="FunCoup" id="A0A0D2X1Y9">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1Y9"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Y9"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Y9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="10">
        <location>
            <begin position="921"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="823"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1013"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1149" mass="123664" checksum="48EDA3B127A42248" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2K9</accession>
    <name>A0A0D2X2K9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363377.2">
        <property type="nucleotide sequence ID" value="XM_004363320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2K9"/>
    <dbReference type="STRING" id="595528.A0A0D2X2K9"/>
    <dbReference type="eggNOG" id="KOG1916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2K9"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032401">
        <property type="entry name" value="EDC4_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16529">
        <property type="entry name" value="Ge1_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 WD40 repeat region" evidence="8">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="773"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="918" mass="97157" checksum="AE24BE0B3130FDBE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2Q0</accession>
    <name>A0A0D2X2Q0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363549.2">
        <property type="nucleotide sequence ID" value="XM_004363492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2Q0"/>
    <dbReference type="STRING" id="595528.A0A0D2X2Q0"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2Q0"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2Q0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="512" mass="54942" checksum="7CC6ABE85BB44374" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3A1</accession>
    <name>A0A0D2X3A1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270443.1">
        <property type="nucleotide sequence ID" value="XM_011272141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3A1"/>
    <dbReference type="InParanoid" id="A0A0D2X3A1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="2">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="736" mass="81630" checksum="5BAC410818B95021" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C5</accession>
    <name>A0A0D2X3C5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347515.1">
        <property type="nucleotide sequence ID" value="XM_004347465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3C5"/>
    <dbReference type="eggNOG" id="ENOG502QW3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3C5"/>
    <dbReference type="OMA" id="YCFFSCL"/>
    <dbReference type="OrthoDB" id="998115at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3C5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31152">
        <property type="entry name" value="PLAC8 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31152:SF1">
        <property type="entry name" value="PLAC8 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28714" checksum="D3749A09839F393A" modified="2015-04-29" version="1">MGKSIDKKVADSYENTWEVGICAAPCASPLSFLYGCCLPWCFVFTQRVRILENDLKNRYSCCGGVICGDCCGDTARGCPYFCLCLESFFCFWCALSGNRWLIQSSFYVQNTWFDSFLILFACIFSWVFFIVGLFVPIPFEADCVVQCCYIMFQGCLLTQQEVELDKRMPVGQPSSVHPGVRAGQVVVVADPNRNAYIQGQPQPQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQGYPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3K1</accession>
    <name>A0A0D2X3K1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_005088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346773.1">
        <property type="nucleotide sequence ID" value="XM_004346723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3K1"/>
    <dbReference type="FunCoup" id="A0A0D2X3K1">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3K1"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3K1"/>
    <dbReference type="OMA" id="NLFCTPM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3K1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="255" mass="28372" checksum="0F6720897F5E1A56" modified="2015-04-29" version="1">MSAPSNPATGPYIDPRVTVLPRTVQLTALHTIMRDKETSRNDFIFYSNRLIRLLIEAGLCLLPFEDKAVTTPTGTHFAGKEFSAKLAGVSIMRAGESMEGPLRDVCKMVRIGKILIQRDESSPSKEAKLFYCKLPVDIHERHVILLDPMIATGGSAIKAIEVLRQHGVKEENIIFLNIISCPEGISNVLTACPLVKIVTTWVDDSLNNHKYILPGLGDFGDRYFGTEDDQHGTRERTYSLSSESAFAELMLKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Q4</accession>
    <name>A0A0D2X4Q4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Q4"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Q4"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Q4"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Q4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="270" mass="30290" checksum="B5BA8F05B4346163" modified="2015-04-29" version="1">MALALHASSARTMAAAIAAIRLTTHPRLFSTSFPRSSSSSSSSSSTGPKRNADGTLRTHYSVLGLRPTATQAEIKQRFYQLSKQLHPDVNKAEDSHMQFTELSEAYSVLSSYEMRQKYDRSLRLEQATWRPAASQQGGQHRKGQNSSAHDDSTSSTNPSSKGPAQGSQKYSSEDRARFKFNFEEHYRHHYGQETRGTTGDAQNQHWDPHVWENLYRETAKQNKRDAVEFAKLNKSPLLLVGAITIGCLLAAEAARSWLRYQRDKQDKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X524</accession>
    <name>A0A0D2X524_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343420.2">
        <property type="nucleotide sequence ID" value="XM_004343370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X524"/>
    <dbReference type="FunCoup" id="A0A0D2X524">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X524"/>
    <dbReference type="InParanoid" id="A0A0D2X524"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X524"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="474" mass="50328" checksum="676E637BAC881C5F" modified="2015-04-29" version="1">MSIPVPTVHSLGDVYSSDALSAQKGRYDQIRTAFASAFDGAVPDFYARAPGRVNLIGEHVDYSGYGVLPMAIAQDIVVAVAIAKTPGTQCTIANTNPKHAKFSFDGANIVIDTKKHHWGNYAMAGYKGITEALGLTSPRSLYLMVDGVIPAGAGLSSSSALVCCIALAVARGHDKVLTKLEFAEICTKCERYIGTEGGGMDQSISFMANQGAAMNIEFGPLRAFPVKLPDGAAFVVADSSVVSEKQVTAATNFNLRVVECRLSALLLAKLGGVQNWQEARTILRAQNALNASFDAMLALVSKHFHPHDYSLTELSGLFGLPESEIVSSFMSASTVEARSFRLFQRVSHVLQEASRTAQFKTVCDTAPDATTALAKLGQLMNDSHTSCRDLYECSCEELDDLTSICRQQGALGSRLTGAGWGGCCVSLVPSDKVDAFVANVKRLYFERKGIANGLIFASPPGCGAAIVASDAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5B6</accession>
    <name>A0A0D2X5B6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEPDC5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_010136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5B6"/>
    <dbReference type="STRING" id="595528.A0A0D2X5B6"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5B6"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5B6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="2">
        <location>
            <begin position="608"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1064" mass="113136" checksum="ABAA5096FDB7155B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5E9</accession>
    <name>A0A0D2X5E9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-cell activation protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342867.2">
        <property type="nucleotide sequence ID" value="XM_004342818.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5E9"/>
    <dbReference type="STRING" id="595528.A0A0D2X5E9"/>
    <dbReference type="InParanoid" id="A0A0D2X5E9"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5E9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="652"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="913" mass="95335" checksum="8D68BD0D05300ED6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3H0</accession>
    <name>A0A0D2U3H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_001185</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366056.1">
        <property type="nucleotide sequence ID" value="XM_004365999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3H0"/>
    <dbReference type="FunCoup" id="A0A0D2U3H0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U3H0"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3H0"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3H0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="588" mass="64399" checksum="8D750ECFD3CD438A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6H2</accession>
    <name>A0A0D2U6H2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_009484</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U6H2"/>
    <dbReference type="eggNOG" id="KOG1225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6H2"/>
    <dbReference type="OrthoDB" id="9930377at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6H2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22842">
        <property type="entry name" value="Gal_Rha_Lectin_BGal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF3">
        <property type="entry name" value="INTEGRIN BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0401">Integrin</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252379" description="Integrin beta" evidence="15">
        <location>
            <begin position="25"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="16">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE90746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2354" mass="248835" checksum="B0EE5C1CDEB16426" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6T8</accession>
    <name>A0A0D2U6T8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348874.1">
        <property type="nucleotide sequence ID" value="XM_004348824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6T8"/>
    <dbReference type="STRING" id="595528.A0A0D2U6T8"/>
    <dbReference type="InParanoid" id="A0A0D2U6T8"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6T8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="460" mass="49492" checksum="6AF49D70EA8111B0" modified="2015-04-29" version="1">MKLKLKSSRKSHSQTAQLVDEHSSAPVAAQPSADELAQLEADYAALCRTCTVVALGSPGGGASTLVRLFRLLWSPPSDVAGLQSAFAPVIQCNTIDSMLVVLKTMGQLGVSFVGDEASKAAAAKHLQEEFVNPYMAPPTVEQWQAWEQAGLRPLYGLPPLSPEQRADVSTATSNLLSLIQDAGVRTAGGSLVSSQVWAMNDPPEYMFRHAARICAAVDYAPTIQDVIRSRQYSRLFDAAEFEAPDSSANDSSGTTSQQQQQRRVIVLEPGQRHSLLAKHTSDKWLRCFVERPAGTMKVTFSTSVVAYTQPAAQSGRTAMHDAIDQVQALCKRLYAPLFTATRAAENDGLLEFSHVPRAPPTGPPTLHIILTRMDLLRHRLCTKSLASVFPDFHQPHPSNFPPSTSAEVDALVQAANAFLAKLFATAAVSAGAPPLLVKVHLQAAILTAEVAQQLTSIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAY7</accession>
    <name>A0A0D2UAY7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364053.1">
        <property type="nucleotide sequence ID" value="XM_004363996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAY7"/>
    <dbReference type="FunCoup" id="A0A0D2UAY7">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UAY7"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UAY7"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UAY7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12317">
        <property type="entry name" value="RRM4_RBM19_RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="607"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="818"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1179" mass="125698" checksum="E1EFBAE98BF2039B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UD16</accession>
    <name>A0A0D2UD16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bleomycin hydrolase</fullName>
            <ecNumber evidence="2">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_003828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363556.2">
        <property type="nucleotide sequence ID" value="XM_004363499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UD16"/>
    <dbReference type="STRING" id="595528.A0A0D2UD16"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UD16"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UD16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="645" mass="71067" checksum="7782DD5A81D42B28" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGN2</accession>
    <name>A0A0D2UGN2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome maturation factor UMP1 family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGN2"/>
    <dbReference type="STRING" id="595528.A0A0D2UGN2"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGN2"/>
    <dbReference type="OMA" id="HADMEKK"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="110" mass="12440" checksum="670AA3F7F912494B" modified="2015-04-29" version="1">MRHGLHQARDDLAPLHPVAFIQDTFDAHQDHLRLSMLGLTQGQQAVMRLNMERNILSRVWRGPGLPSSNIGLETITGRDDRIAWEDVLNDPNMSEVSPALHETAEARLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJN7</accession>
    <name>A0A0D2UJN7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJN7"/>
    <dbReference type="STRING" id="595528.A0A0D2UJN7"/>
    <dbReference type="eggNOG" id="KOG3231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJN7"/>
    <dbReference type="OrthoDB" id="5594417at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJN7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="163" mass="17436" checksum="F86A8D761795B056" modified="2015-04-29" version="1">MAKQGNDDAARVLAKQLVRIRAAKTKSVATSARVSSIGAQTTAMHSQMKMAGAMAGASKVMSSMNKQIDVAQMQAMMQDFEKQSMTMDMKEDMMNDTIDSVMDGDADEEESVNIMNQVLDEIGIDISTKLSSAPRHAVGEASSSSSADMSSLEARMASLRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJV1</accession>
    <name>A0A0D2UJV1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345424.1">
        <property type="nucleotide sequence ID" value="XM_004345374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJV1"/>
    <dbReference type="InParanoid" id="A0A0D2UJV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="10821" checksum="F7088B1C7867304D" modified="2015-04-29" version="1">MASSTATVTGSAADSADVVVDARLALLLERSKVSIEACIAPVELELNAIEAARADKEAFVLTSVADAVAAAEADLQTARKQSLRDLSKTADDAAWQQKPFLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKQ3</accession>
    <name>A0A0D2UKQ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270609.1">
        <property type="nucleotide sequence ID" value="XM_011272307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKQ3"/>
    <dbReference type="FunCoup" id="A0A0D2UKQ3">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UKQ3"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKQ3"/>
    <dbReference type="OMA" id="PCTALTW"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="491"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="665"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="706" mass="75298" checksum="CB2838F96A7DE348" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULN3</accession>
    <name>A0A0D2ULN3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase D3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULN3"/>
    <dbReference type="STRING" id="595528.A0A0D2ULN3"/>
    <dbReference type="eggNOG" id="KOG3603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2ULN3"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2ULN3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252744" evidence="3">
        <location>
            <begin position="31"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="488" mass="53043" checksum="D0D383591CE8E17C" modified="2015-04-29" version="1">MLSCARGRVGAVAQVLTVLCLLVVVACCSAAATHATTSPSSSSSLSSSSSSSSVQGDWRNAAADAEQRLASSWRAATQHRSKLDSATQQQHEQQQQQQQEHNADQLSCSGTARIAETIPSNLTLHTDLSTGDAWLQLINNATQTLDLAVFYMTLLNGTDIGQKVFNALVAACDRNVAINVAISAPNAQFPDDDLVTLQQQCGSQISVAYLNMSTFFDGGVLHTKFIIADGQAFYIGSANMDWRSLSEVKELGIVVDKCNLLASDLKKVFDVFVLASNLERLPAFWPSQLDTDFNASNPATIAVNHESGSAFISSSPHAFCPAGRSFDRDALEFAILSAQTNVSIEVMDYLPITVYEEPQVYWPALDTAIRTVAFNKKVQVNMLIAYWDNSIEGMIPFLKSLNDLDNVEVRLMEIPKNTPYVPFTRVNHAKFIVTDSLVAISTSNYVGDYFINTAGSSLVTDAKSLVSSVQSRFDRDWASQYSVPLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNY3</accession>
    <name>A0A0D2UNY3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Krueppel-like factor 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_006953</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343677.1">
        <property type="nucleotide sequence ID" value="XM_004343627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNY3"/>
    <dbReference type="STRING" id="595528.A0A0D2UNY3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNY3"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000367">
        <property type="entry name" value="Zinc finger protein 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="745"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="564"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE96666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="821" mass="89307" checksum="193309E9AAC93D16" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UP42</accession>
    <name>A0A0D2UP42_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343752.2">
        <property type="nucleotide sequence ID" value="XM_004343702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UP42"/>
    <dbReference type="FunCoup" id="A0A0D2UP42">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UP42"/>
    <dbReference type="eggNOG" id="ENOG502RVFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UP42"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UP42"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF13">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE PSPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="16067" checksum="85E5B3BD20E68FC3" modified="2015-04-29" version="1">MLRFTAPKLASTISLALRRGYPAGAQFIAQVNAAKSKVKEVTIDQFNADQKKAIAAGAKPSLLIDVREDAEWTASRIPGAIHLGKGIIERDIEATVPDTKANLVLYCGGGFRSALAAKALQDMGYTSVSSLIGGIGEWRSKGLPLDNSPGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPT2</accession>
    <name>A0A0D2UPT2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box/WD repeat-containing protein pof1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343368.1">
        <property type="nucleotide sequence ID" value="XM_004343318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPT2"/>
    <dbReference type="STRING" id="595528.A0A0D2UPT2"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPT2"/>
    <dbReference type="OMA" id="PTHTACY"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF681">
        <property type="entry name" value="F-BOX PROTEIN MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE97006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="601" mass="66215" checksum="32E0C5A9CBED54A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIX1</accession>
    <name>A0A0D2VIX1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U2-associated SR140 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIX1"/>
    <dbReference type="STRING" id="595528.A0A0D2VIX1"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIX1"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="401"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="682"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="906" mass="101638" checksum="0A0615CA98DDC115" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJN2</accession>
    <name>A0A0D2VJN2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364403.1">
        <property type="nucleotide sequence ID" value="XM_004364346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJN2"/>
    <dbReference type="InParanoid" id="A0A0D2VJN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="103" mass="11231" checksum="6C557D8D6BF6777D" modified="2015-04-29" version="1">MEIGWRLTPLFVDQGVNERAWDVGKRVLLYGVTSPSLQAKEVACANRAQSVLASHGAYAANICQLLNGAVNTIHLRPNEVCRSNRCDFSTPSRLVLSLAVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK03</accession>
    <name>A0A0D2VK03_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mon1a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK03"/>
    <dbReference type="FunCoup" id="A0A0D2VK03">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VK03"/>
    <dbReference type="InParanoid" id="A0A0D2VK03"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK03"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="2">
        <location>
            <begin position="197"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="3">
        <location>
            <begin position="358"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="4">
        <location>
            <begin position="498"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="609" mass="65817" checksum="1AA05B628D948B51" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKE2</accession>
    <name>A0A0D2VKE2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKE2"/>
    <dbReference type="STRING" id="595528.A0A0D2VKE2"/>
    <dbReference type="eggNOG" id="KOG4535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKE2"/>
    <dbReference type="OrthoDB" id="66533at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="2">
        <location>
            <begin position="490"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1186" mass="123348" checksum="29B57107E232388D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLN4</accession>
    <name>A0A0D2VLN4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348988.2">
        <property type="nucleotide sequence ID" value="XM_004348938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLN4"/>
    <dbReference type="FunCoup" id="A0A0D2VLN4">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLN4"/>
    <dbReference type="eggNOG" id="KOG0906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLN4"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLN4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="120"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="669"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="945" mass="105022" checksum="3521DD624AA4D795" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM09</accession>
    <name>A0A0D2VM09_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_002306</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM09"/>
    <dbReference type="STRING" id="595528.A0A0D2VM09"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM09"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM09"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="290"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="803"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE91122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1118" mass="121053" checksum="59A141D82999DD5C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMS9</accession>
    <name>A0A0D2VMS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMS9"/>
    <dbReference type="FunCoup" id="A0A0D2VMS9">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMS9"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMS9"/>
    <dbReference type="OMA" id="ELEWVEQ"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="583" mass="64095" checksum="E6893DA790C16D7B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN77</accession>
    <name>A0A0D2VN77_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGC protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348626.1">
        <property type="nucleotide sequence ID" value="XM_004348576.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VN77"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN77"/>
    <dbReference type="OMA" id="HARSTEP"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="1501"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1557" mass="168913" checksum="9065D36A8B3F82AB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNZ3</accession>
    <name>A0A0D2VNZ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363953.2">
        <property type="nucleotide sequence ID" value="XM_004363896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNZ3"/>
    <dbReference type="STRING" id="595528.A0A0D2VNZ3"/>
    <dbReference type="eggNOG" id="ENOG502QSGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNZ3"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNZ3"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01569">
        <property type="entry name" value="PBEF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006629">
        <property type="entry name" value="PRK09198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005943">
        <property type="entry name" value="NMPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinamide phosphoribosyltransferase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="178"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005943-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="469" mass="52305" checksum="94CDECB0CE5CEA27" modified="2015-04-29" version="1">MARQLMSDNIILLTDSYKIAHYRQYPPKTTTVYSYFESRGGDFPETVFFGLQYILERYLAGPVVTQAKIDEAKEVFALHFGDDKLFNAEGWEYILKEHNGHLPIRIKAVPEGTVVPVKNVLITIENTDPQTYWLTNYLETILVEVWYPLTVATYSRELKKIIAGYLSETADDLSGLPFKLHDFGYRGVSSVETAGIGGASHLVNFMGTDTIAGFMLARQYYGSTMAGYSIPATEHSTMTSWGRAGESAAYKNLLEQFPSGVVACVSDSYDIFNACENIWGKELKDLIVERGKDGKSILVIRPDSGDPATVVVRILEIFGERFGTTTNSKGFKVLPPYIRIIQGDGISYASLKQILQHMKDHKWSADNVAYGSGGALLQRHHRDTQKCALKCSFAVVNGENVNVFKDPITDPGKKSKTGRLTLERTEDGKFVTQVESKGDPAKDLLVTVFENGVMVKRWTLDEIRERAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPT8</accession>
    <name>A0A0D2VPT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348389.1">
        <property type="nucleotide sequence ID" value="XM_004348339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPT8"/>
    <dbReference type="InParanoid" id="A0A0D2VPT8"/>
    <dbReference type="OMA" id="HKANDIT"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269441" description="Reelin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="56518" checksum="84607A3996C01A5F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ42</accession>
    <name>A0A0D2VQ42_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_003591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363319.1">
        <property type="nucleotide sequence ID" value="XM_004363262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ42"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ42"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ42"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ42"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000113">
        <property type="entry name" value="Beta-adaptin-like protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="8">
        <location>
            <begin position="712"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="829" mass="92679" checksum="2B020B106259DC6B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQX5</accession>
    <name>A0A0D2VQX5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RhoGEF domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQX5"/>
    <dbReference type="eggNOG" id="KOG3524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQX5"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="820"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1352" mass="145959" checksum="E7660606599AFA99" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR19</accession>
    <name>A0A0D2VR19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Atypical/PI3K/PI4K protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347915.1">
        <property type="nucleotide sequence ID" value="XM_004347865.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VR19"/>
    <dbReference type="eggNOG" id="KOG0904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VR19"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08380">
        <property type="entry name" value="C2_PI3K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00891">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035448">
        <property type="entry name" value="PI3Kc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045580">
        <property type="entry name" value="PIK3CG_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19710">
        <property type="entry name" value="PIK3CG_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="10">
        <location>
            <begin position="701"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="12">
        <location>
            <begin position="880"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="11">
        <location>
            <begin position="1189"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1431"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1722" mass="189778" checksum="B34173087E1B7B5E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR38</accession>
    <name>A0A0D2VR38_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery associated TMA7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR38"/>
    <dbReference type="STRING" id="595528.A0A0D2VR38"/>
    <dbReference type="eggNOG" id="KOG4766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VR38"/>
    <dbReference type="OMA" id="KKGPMNT"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="6747" checksum="4CF6F2549EA8C085" modified="2015-04-29" version="1">MSGRDGGKKKPLKQAKKESRELDDDDLAFQAKQREDAKKLAELKAKAAGKGPLVSGGIKHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRU4</accession>
    <name>A0A0D2VRU4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TTK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRU4"/>
    <dbReference type="STRING" id="595528.A0A0D2VRU4"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRU4"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="831"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="670"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1097" mass="117964" checksum="C9EB72DC66A70FA5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSX0</accession>
    <name>A0A0D2VSX0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347691.1">
        <property type="nucleotide sequence ID" value="XM_004347641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSX0"/>
    <dbReference type="eggNOG" id="KOG0905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSX0"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="353"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="490"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="629" mass="65364" checksum="6C78B1BA4D238681" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTP4</accession>
    <name>A0A0D2VTP4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ataxin-3 homolog</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Machado-Joseph disease-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_005267</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTP4"/>
    <dbReference type="STRING" id="595528.A0A0D2VTP4"/>
    <dbReference type="eggNOG" id="KOG2935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTP4"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTP4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000018">
        <property type="entry name" value="Ataxin-3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="20">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="189"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE94652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="293" mass="31316" checksum="DA9454FFA752FF8A" modified="2015-04-29" version="1">MALSAAEVVFHEQQQGALCAQHCLNAMLQGSYFSAVDLADIARQLDAAELSAMAEGGYSRELAKFARQGSSNMDDSGFFSIQVITQALNVWGIKCVPFMSEDAVDARRDPTHEQGFICNRRQHWFSIRRFGPHWANLDSTLKGPNFITGTYLTLFLNQLQSDGYSIFVIRGNLPPSAADAVLSQLPASQIPNSGARTSGPAAPSAAPRGNIHTLSSLSASRSSSPAQSGQTIAKHNSSGTSGLDSVHLDPETIQSLAAGVKNANQPAAPARPVDMDEMRAKRLQRFGNSNAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUY1</accession>
    <name>A0A0D2VUY1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346356.2">
        <property type="nucleotide sequence ID" value="XM_004346306.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUY1"/>
    <dbReference type="STRING" id="595528.A0A0D2VUY1"/>
    <dbReference type="eggNOG" id="KOG2092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUY1"/>
    <dbReference type="OrthoDB" id="6779347at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUY1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="913" mass="98143" checksum="D462E7DB8B86F0DA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVE5</accession>
    <name>A0A0D2VVE5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVE5"/>
    <dbReference type="InParanoid" id="A0A0D2VVE5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110440" checksum="D27CE3B6C8685F37" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVH0</accession>
    <name>A0A0D2VVH0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345521.1">
        <property type="nucleotide sequence ID" value="XM_004345471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVH0"/>
    <dbReference type="STRING" id="595528.A0A0D2VVH0"/>
    <dbReference type="eggNOG" id="KOG4235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVH0"/>
    <dbReference type="OMA" id="EVCHERL"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVH0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF35">
        <property type="entry name" value="DEOXYADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="2">
        <location>
            <begin position="232"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="384" mass="43408" checksum="10D7F9E7D6295B57" modified="2015-04-29" version="1">MTGQRVLRIALEGNISAGKSTFLDILSQELDIVIVPEPVSRWQQVDEIRNDPRSAAAFREMAIFQGEAGSEPEHQDGDSHAHPAAFARGTTPSIFELENSNTFDSIPASQDTGGNLLSLFYNSPNRWSFTFQIYACLSRIRAQQRPPENPHPKTLFIGRKNSNSQSQSESPTSDVIEKDSTPAILDRGLKRSASEDQDPATTSSSTEVSTVESGNTRAQARPRLASVSEIPPTSIHFTERSVFSDRYCFALNCVETGLMTRPEFFIYQEWHSFMEASVPEAMKLDGIVYLRSTPEVCHERLQRRAREEESAVSVDYLHQLHQRHEDWLIRKKESLKVSPLASSCPLLIVDSDKEFQHDPVRCKEMVEQVKQFMLDCRAQFEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVW1</accession>
    <name>A0A0D2VVW1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_006043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345633.1">
        <property type="nucleotide sequence ID" value="XM_004345583.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVW1"/>
    <dbReference type="STRING" id="595528.A0A0D2VVW1"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVW1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="175"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="504" mass="56028" checksum="8341D6111EF6BFC1" modified="2015-04-29" version="1">MSSSDHHPKGKGKDKDKDKDTDKTIHGNGASETVLSSRSSSSRPSSSSSSQRGLSRVLHWGPMLALSVIVFISFSMIVACVHGNPPLEARTVLTGRSTVYPRGHPQHRDPASSGGSPSTSLDVVFKPWGALQLGVFLLMLAQILSNYFLAMVRGPGYAPPGWQSAVTGNVADFVQFCTLCDEFKAPRAHHCRLCNRCILRMDHHCPWVNNCVGHNNQRNFVLFVTWVPLTAVYTIYIMSHWCWTLLGSGRLLRLYSIDLVLCVFGVALSIGVMLAVAFLAHHQFSVIFRNMSDIEEWIADKASNRMLKEKSGEVFTYPYDLGRRANWVQVMGPGVLQLLWPWYEPSTSLDAQLHEHPGKRTALKQPITASNGVFWPVHETCHQFSFTQEQLKQKQRKLAHAQLVRVARPFSGRWWGFGIGGCRLLWNFPAFDDTQLAVSAGQDVLVLRGHKGWLYGENRGVGADSDTPNPDSTAAAASTSNNDVHVRDHPRGWFPEACVNVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX09</accession>
    <name>A0A0D2VX09_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_006481</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345230.2">
        <property type="nucleotide sequence ID" value="XM_004345180.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VX09"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VX09"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX09"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="134"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1017"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1461"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1576"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1336"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1477"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1601"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1635"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1695"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE96112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1716" mass="188905" checksum="F6776929B0C563A4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXK9</accession>
    <name>A0A0D2VXK9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXK9"/>
    <dbReference type="InParanoid" id="A0A0D2VXK9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="972" mass="103460" checksum="E472D5E8923446BE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W085</accession>
    <name>A0A0D2W085_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270821.1">
        <property type="nucleotide sequence ID" value="XM_011272519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W085"/>
    <dbReference type="STRING" id="595528.A0A0D2W085"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W085"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W085"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="303"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="489"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="65144" checksum="A9E00C4EDA39180A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0T8</accession>
    <name>A0A0D2W0T8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0T8"/>
    <dbReference type="InParanoid" id="A0A0D2W0T8"/>
    <dbReference type="OrthoDB" id="2154664at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0T8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254096" evidence="2">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="382" mass="42646" checksum="EA9C9B3D724B0DAF" modified="2015-04-29" version="1">MSNAKHVFGCLLVFAVICSVMLYSTNTESDARPQAPVETADPQRVARPEQTEPTPSRFIARSELVFGQLDAQRLMNNSAWVSPSVVRLHDGPDGWPRPWTALTFSGTMRSFKYPALLDSLRKNLLAALGGTILIFSNSRLEDWPRSGLGCANSQEDLFDALRDLLPGKAEHFVVWRSFQVPDPMWTHNCASRPSLIQSLSILDSYSLALDYENQVGVKFDWIVRARPDVGFPEPLPSLASLNESVFVPGNSEHQLSNQFAIVPRKFSDVFLRLPPVEIECAANNDNDRLRLWLDANNIPYYRHKAIHFTIVRAYYGAECFRSCGGFGVGSQCELRKVCEAMFGEITNDRKSKKLDAQLLISELKTPHAGCSVSLSKTPPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0V7</accession>
    <name>A0A0D2W0V7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343054.1">
        <property type="nucleotide sequence ID" value="XM_004343004.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W0V7"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0V7"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0V7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF30">
        <property type="entry name" value="F-BOX DNA HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="14">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1093"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1311" mass="142303" checksum="3A810D7C730B853D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0X2</accession>
    <name>A0A0D2W0X2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Growth-inhibiting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342578.2">
        <property type="nucleotide sequence ID" value="XM_004342529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0X2"/>
    <dbReference type="STRING" id="595528.A0A0D2W0X2"/>
    <dbReference type="MEROPS" id="S53.003"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W0X2"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0X2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266187" evidence="8">
        <location>
            <begin position="30"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="240"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="588" mass="62566" checksum="26CC7F1998938B28" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1D1</accession>
    <name>A0A0D2W1D1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1D1"/>
    <dbReference type="InParanoid" id="A0A0D2W1D1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="73" mass="7689" checksum="BB252151CD16030F" modified="2015-04-29" version="1">MSASASNIPRTLNRISSTVSTILARVAANSSTASSQPFKLIPKLPSAPRTATARRGAWQPSPAQQAAQTKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1V6</accession>
    <name>A0A0D2W1V6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346390">
        <property type="protein sequence ID" value="KJE98332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1V6"/>
    <dbReference type="STRING" id="595528.A0A0D2W1V6"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1V6"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1V6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254062" description="PKD domain-containing protein" evidence="7">
        <location>
            <begin position="34"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="8">
        <location>
            <begin position="699"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="8">
        <location>
            <begin position="793"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE98332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="937" mass="101399" checksum="107878568F06A08D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHI5</accession>
    <name>A0A0D2WHI5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malonyl-CoA decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365498.2">
        <property type="nucleotide sequence ID" value="XM_004365441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHI5"/>
    <dbReference type="STRING" id="595528.A0A0D2WHI5"/>
    <dbReference type="eggNOG" id="KOG3018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHI5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHI5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="2">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="264"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="57912" checksum="3A715D155F7CFF1B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHQ5</accession>
    <name>A0A0D2WHQ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365571.1">
        <property type="nucleotide sequence ID" value="XM_004365514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHQ5"/>
    <dbReference type="STRING" id="595528.A0A0D2WHQ5"/>
    <dbReference type="eggNOG" id="KOG3198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHQ5"/>
    <dbReference type="OMA" id="QMERWIC"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17740" checksum="E413FCE29F4F681B" modified="2015-04-29" version="1">MAHLTTDPTNVARWVVVYPIYINSRKTLEQGRRLGVGYCCDSPTAQEVALVVKANLKLECILEWEKAYPRDFMQRGRVRVQLFDANKKPLNSGIPNRQTLLKYIALQINKIPNRTLPPTDDAAIFAQFVPTATTSSASATPPANASAGGNTNNKKNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHQ6</accession>
    <name>A0A0D2WHQ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365576.1">
        <property type="nucleotide sequence ID" value="XM_004365519.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHQ6"/>
    <dbReference type="InParanoid" id="A0A0D2WHQ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="336" mass="36416" checksum="4AA3B122FBBE2AB3" modified="2015-04-29" version="1">MQRLLPVTGWSATRAASLLSACSTIALRRRAANPAMSFSTAAQAPANKQSSGQWTRVGTAVAVMLGIATLLQGTKAQDRLALLEQWAEDQLRSVVCTLGLYQAQLGKRPVLLPVIEHLEREREAQRKATIVGKLPSDPEHMEAIFRAHSPTLTRIHEYLAETEQSHEAPIVRRLRDVLQRQEQQQLSSSSAAGSSSSSSSSSSWWSSSSSHSKQQQAQGQHDDPAIPLSVVLAGLRQVVAELETEALDLALPLRLWPQAPSSLQNPDLWKDYMTEMERKADLLTNRSIGEARLSIDFQYDKQPAVAPHAPTSAASSSATAVDAESSKPSSSGTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIH6</accession>
    <name>A0A0D2WIH6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001055</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365926.1">
        <property type="nucleotide sequence ID" value="XM_004365869.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIH6"/>
    <dbReference type="eggNOG" id="KOG1144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIH6"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIH6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="852"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="679"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1447" mass="154271" checksum="09455DAD60D637D8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ20</accession>
    <name>A0A0D2WJ20_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365584.1">
        <property type="nucleotide sequence ID" value="XM_004365527.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ20"/>
    <dbReference type="InParanoid" id="A0A0D2WJ20"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="185" mass="19324" checksum="0AC5B4D0ED517152" modified="2015-04-29" version="1">MVKCAAFGVAIVFAVAFAVLAAGFASPVWVARKINNDYSVGLISLCINDDCGRYDTLSDMQDATNDYVVAAAFLIGIAVIAVGFCVLISLVAIFSPRAIVACYPLATLAIILTVIGLLLVPAGLKDNAAILFTCVSPGDTYELPDTCEATTGLILTAVGLGLLLIAEMVLGCLDKKHIREDGMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ45</accession>
    <name>A0A0D2WJ45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CG-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ45"/>
    <dbReference type="eggNOG" id="KOG0520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ45"/>
    <dbReference type="OrthoDB" id="407555at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005559">
        <property type="entry name" value="CG-1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03859">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01076">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51437">
        <property type="entry name" value="CG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CG-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1170" mass="126377" checksum="564895A709CEB5BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ51</accession>
    <name>A0A0D2WJ51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ51"/>
    <dbReference type="InParanoid" id="A0A0D2WJ51"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43864" checksum="E249C91DB01FB072" modified="2015-04-29" version="1">MQVALDTLTALDEFFFEPIAKHLHSLHPNLPSIADRVTSVQGSWHLSPKQHAIEFVIYNILFALAVWLAAKRLPNWRSVNVVLLLSAFLPLVQFSVSSTHIHQHTTTFSLSSTKRCQVCVCVDVDVDGCCTEKLTENTHIGCWHNSTLVSETTVPLSSRGWFPRLLDALCTVAMLVFYGSAIYYKTVRGHLLFLLQPCHIFSVLLLLLCFWPEKSLKRHVLFHIHIHCLWGALLALVFPDFRDYGMYLEIHFFIMQHLALVIVPLVWVYTGRFPLVSMYGRGFSVTIFAFFVHALYHSFVLASLALYTGNNLNYLMSPPTGILESFGSFYRPVMYAFCLVLTIIVRFVVIGTAAKLLRSKPVDVNANGHFEVYTSPAVQHQHQHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJA7</accession>
    <name>A0A0D2WJA7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365760.1">
        <property type="nucleotide sequence ID" value="XM_004365703.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJA7"/>
    <dbReference type="FunCoup" id="A0A0D2WJA7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJA7"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJA7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="630"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="775" mass="82955" checksum="344D24586F143520" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJS0</accession>
    <name>A0A0D2WJS0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_001090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJS0"/>
    <dbReference type="STRING" id="595528.A0A0D2WJS0"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJS0"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJS0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="299"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="372"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="620"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="911" mass="97068" checksum="F06C68A38DE30682" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJV9</accession>
    <name>A0A0D2WJV9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein TypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364607.1">
        <property type="nucleotide sequence ID" value="XM_004364550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJV9"/>
    <dbReference type="STRING" id="595528.A0A0D2WJV9"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJV9"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJV9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01891">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.250:FF:000001">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000002">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000055">
        <property type="entry name" value="GTP-binding protein TypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="entry name" value="bipa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048876">
        <property type="entry name" value="BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047041">
        <property type="entry name" value="BipA_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21018">
        <property type="entry name" value="BipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="726" mass="77680" checksum="25EE178BD12778A2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKQ9</accession>
    <name>A0A0D2WKQ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKQ9"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKQ9"/>
    <dbReference type="OrthoDB" id="9989163at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028422">
        <property type="entry name" value="GREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048657">
        <property type="entry name" value="GREB1-like_cpSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049100">
        <property type="entry name" value="TAGT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15720:SF14">
        <property type="entry name" value="GREB1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15720">
        <property type="entry name" value="GREB1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20692">
        <property type="entry name" value="cpSF2-GREB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20691">
        <property type="entry name" value="TAGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GREB1-like circularly permuted SF2 helicase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="GREB1-like circularly permuted SF2 helicase" evidence="3">
        <location>
            <begin position="528"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="TET-Associated Glycosyltransferase" evidence="2">
        <location>
            <begin position="818"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1459" mass="161249" checksum="55F219A59FB8E000" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMF1</accession>
    <name>A0A0D2WMF1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270269.1">
        <property type="nucleotide sequence ID" value="XM_011271967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMF1"/>
    <dbReference type="STRING" id="595528.A0A0D2WMF1"/>
    <dbReference type="eggNOG" id="KOG1409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMF1"/>
    <dbReference type="OMA" id="EIRCLRW"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMF1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="396" mass="44785" checksum="09F1875F04978412" modified="2015-04-29" version="1">MSDSGPVLAGTLHGHVDVVNAIVYLPEMECVISASDDRTLRVWLRRDNGDWWPSVCQTLAGPVSALAFDAKSRRLFAGVELGNIFEYSCSEDLNRLAIKQDHRAHTARVTAINFVPDHEWILSVGRDKFFQWLDAQTGRRLGCFQSDAWCSCLQFDPVSKFAFLGDYGGNIELLKVDDGRLSLVSTLKGHEGSIRSLAWDGKKRRLYSGSFDKRIIVWDIGSQKGVTYEFYAHLSKIKSVVFIPEDRRLVSSGDDQKLIFWDLKKRRLEAPEWAEAPDCQKCGTPFFWNFKKKLNVTRQHHCRMCGKALCDDCSARRTTLPKMGFELPIRTCQECFSTVGEKDRRPYCKTYGAKHAVADMVWSASTRELVTAGTNGLIKIWKVPTIGHDASSEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMF8</accession>
    <name>A0A0D2WMF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dehydrogenase/reductase SDR family member 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270273.1">
        <property type="nucleotide sequence ID" value="XM_011271971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMF8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMF8"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMF8"/>
    <dbReference type="OMA" id="TYIMTTA"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052992">
        <property type="entry name" value="SDR_member_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44656">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44656:SF7">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36180" checksum="946E67C1EA049B69" modified="2015-04-29" version="1">MSTTAYRTAAWLWGGARRYTNAGYERAAASFNAGDLDVTVRVEGRSFMVTGANSGIGYATCREIVLRGGVLHMVCRNPERAEAAQRKLLEETKVSPAMVEVHILDISCIKDVARFAQEFCASGKPLHVLINNAGCMVRERQTTSEGLEVNFATNTLGPYVLTTALIPVLAKAPNARVLNVSSGGMLLVKLDMTDPQLERPTKFDGQMAYAHNKRQMMVIMDHWAKVHASDGISFYSMHPGWADTPAVRESMPDFHKFWKNKLRTEEQGADTLVFLAISGSVTPEQSGEFFEDRAVTSKHLSLCRTQSTPAEEEQLVQYVSELASKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMN0</accession>
    <name>A0A0D2WMN0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363977.1">
        <property type="nucleotide sequence ID" value="XM_004363920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMN0"/>
    <dbReference type="STRING" id="595528.A0A0D2WMN0"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMN0"/>
    <dbReference type="OMA" id="NYPWIHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="455"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="66618" checksum="D12BC893436D8637" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMP1</accession>
    <name>A0A0D2WMP1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMP1"/>
    <dbReference type="STRING" id="595528.A0A0D2WMP1"/>
    <dbReference type="eggNOG" id="ENOG502S7RQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMP1"/>
    <dbReference type="OrthoDB" id="276540at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="727" mass="76032" checksum="01679BC8BA1DE426" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMP2</accession>
    <name>A0A0D2WMP2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_009636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="9"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMP2"/>
    <dbReference type="STRING" id="595528.A0A0D2WMP2"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMP2"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19176">
        <property type="entry name" value="SET_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044428">
        <property type="entry name" value="SETD3_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF203">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="819"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111760" checksum="6DC927FC703D4578" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMR0</accession>
    <name>A0A0D2WMR0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMR0"/>
    <dbReference type="eggNOG" id="ENOG502QU0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMR0"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1662"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1745"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1845"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1927"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1967"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2072"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2098"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1745"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1984"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2045"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2112"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2174"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2246"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2313"/>
            <end position="2324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2359" mass="250541" checksum="7A7DD54AC422CA26" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMV6</accession>
    <name>A0A0D2WMV6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349448.1">
        <property type="nucleotide sequence ID" value="XM_004349398.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMV6"/>
    <dbReference type="STRING" id="595528.A0A0D2WMV6"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMV6"/>
    <dbReference type="OMA" id="ELTCARY"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMV6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254491" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="314"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="405" mass="44285" checksum="78F63C2686498AEC" modified="2015-04-29" version="1">MRPALAIIACVAALSATTVSALNNGLAKTPPMGWSSWNTFECDISETLIHQIADTMVSSGLAKAGFQYINLDDCWMSGRDPTTGRLVPDATKFPSGMSALSEYIHSKGLKFGMYVSAGDITCMGFAGTKGHEQIDAETLAEWNVDYLKMDCCNQTDLVEAHGVYVAMSDALLSTRHDILFSCDTDELLMRMNNHEAPWDWAPGRCNVARIWLDIKDNWPNLMDIVDHASNVMYASGPGYWNDLDILTVGMGGQTDAQYRSHFSLWCLLGSPLLLGNDIRNMTLATLNILTATEVIAVSQDPLAIAGERIRTSIDGTMQVFARPVEGPPGTAAVVLFNRAAVAQNVTFDFYNDLYQNNFCCPPRTPAITVAVRDLWQRQDLGTAVNTTSFVIPAHDVVMVKLTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNU5</accession>
    <name>A0A0D2WNU5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363540.1">
        <property type="nucleotide sequence ID" value="XM_004363483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNU5"/>
    <dbReference type="STRING" id="595528.A0A0D2WNU5"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNU5"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNU5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="730" mass="77631" checksum="FDCED4F144C4F63D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP04</accession>
    <name>A0A0D2WP04_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364119.2">
        <property type="nucleotide sequence ID" value="XM_004364062.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP04"/>
    <dbReference type="STRING" id="595528.A0A0D2WP04"/>
    <dbReference type="eggNOG" id="ENOG502S50Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP04"/>
    <dbReference type="OrthoDB" id="5966951at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP04"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="431" mass="46874" checksum="80D072A7F9E67EBD" modified="2015-04-29" version="1">MDELFDDTCLAMSSSEASFKSGDLDDEPDADLQAYLATSHDNADDDDDDEGEQSSAAAPSGPTVVIKQGWCWKESGGAMGANLFGGKWQRRWFVLYSNHTINYFKAQSDKHPAGTIHLTPSHITNDLKDPKRPRAFGFTVGPQVVHAAVRIYYIAAESAAECTSWQTEIRAAIATCSDATTLPQLLTSGLDTPASWRLQCWEYLKQVIGAKTWCNHDVKNGVTIARMDFSKNGHVSVRLEGSIAVQPDICFDFLRQALDRGGACDYPFRSLREVQSTRDAPEASVLQGHFAIPTIGLRSITVVRSWLRPGTVGTSDSLFGGMLLVTLPDANASDPSSPPPSPSSAKGKGKAGKPFSISVQPSGLVLYAIPPIPDRKNQYGAHTRVVVSMTLDLGGRLQTLLKATYRTGILKIPIRHEFHRLKNLIEESVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPC5</accession>
    <name>A0A0D2WPC5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPC5"/>
    <dbReference type="InParanoid" id="A0A0D2WPC5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="100" mass="9627" checksum="B1C9073A28625030" modified="2015-04-29" version="1">MAKQNKQTASSSADALSTGLAGLSVNDAARAADAARSADAARALAAARVVAYARRDAAAPVPARGAARAPPAARAPPVGVEPTSTSAPAPDAAPTGKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPG2</accession>
    <name>A0A0D2WPG2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348394.1">
        <property type="nucleotide sequence ID" value="XM_004348344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPG2"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPG2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPG2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="118" mass="13228" checksum="271E4272C9BFE3FF" modified="2015-04-29" version="1">MSSGSTSIHTTGAVFNLINLRARVIICGQITQYNGKLDSVEMGPRFLHRLIYTRATIQGILARDYVDRMDEMLPVMIDWLNSGKLKYEQTVVDGFEQLPSALNALFHGKNVGKMLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ41</accession>
    <name>A0A0D2WQ41_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ41"/>
    <dbReference type="STRING" id="595528.A0A0D2WQ41"/>
    <dbReference type="eggNOG" id="ENOG502S2GY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ41"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ41"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="501" mass="55979" checksum="AC128767A09848C3" modified="2015-04-29" version="1">MDDRQRRRSRSPPGRHASSSSSSYADHKSSDGDRRDDRQREPRRDDRDDRDRDRDRARSRDHHDDRRHHERDRDRDRDRDRDRDRDRSSHSGERSSRAPERSKATRSRSASRSSSGSESESDSGSSSSSSSSSSSSGSDSGSSSDSDESDDGRGRKSSSSRSSHRSSSRADKASSSSRHRSSKHGKHGKSKKSHKHHRSSHKRDRHSSKHDQSEARPLPAGVAPLSDTDYFVKHSEFRQWLLEKRKQSFDDLTSTESRKLFTRRFLPAWNGGYLDGKFYAGLTSRDLASSAKTRHKWGFVPNLNPDEVDRVSDTVSSLTRGGASSSAHPPASTNAFGRLIGVPPAPIPEAVSATSGSKRPYSTSLDPAERVLQEEEARKRAQVEKKSERSANYQRINEQFPKTEGREAAIAERQGRAALKKAAEGDAMDYAPGVSVLGGGGSDEFKRLQQIKHQADSRRKEAKAAVLNEKVAAYQLKEQASMAALRQLADMRKQQQQQQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ45</accession>
    <name>A0A0D2WQ45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348272.2">
        <property type="nucleotide sequence ID" value="XM_004348222.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQ45"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQ45"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1572"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1327"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1956"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2094"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1852"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1483"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1971"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2120"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2144"/>
            <end position="2157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2157" mass="228751" checksum="AA9E8F3B67284FE7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WR55</accession>
    <name>A0A0D2WR55_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WR55"/>
    <dbReference type="InParanoid" id="A0A0D2WR55"/>
    <dbReference type="OrthoDB" id="10689734at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WR55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="279"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="419" mass="42748" checksum="940D3CEA5F36B0E5" modified="2015-04-29" version="1">MRLSAANGLASSLPSEQPPTHPPLLRSTHPASSDRSVHAGAATATITATAAVAAAPASSSEITGTLTSSPMHPGAGAVAGWSRAVASKSAASSAVSTPSLSTTTTTTGASSALASTPSSSSSPASVAGQSFFPPTLLRSSSSSATPSVSTSGATAVAHSASSPSTIRPEAQSSSSIINSSNTSSSSSSSTSQAEVPTPRNQPPHANDTIAPNAANAAAANAPASPAAAAAAAAAAPPRMVSPTTPVTPSHSATAAPALVNTSAPVNSNNLFQVKAYFGVSVAELLSGAGEKGPTLPRILVFLCEYMMRYVEDVAQERPAAFEAELRVLFQQNADEELFARARQRFNHGDFFDCDSPIIAFRLLRAFVREMPTPLMPPTMYDDAIHLVQSHLRRATSLLRRNKHYTALLAGFPESTAAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRA3</accession>
    <name>A0A0D2WRA3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smad nuclear interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348275.2">
        <property type="nucleotide sequence ID" value="XM_004348225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRA3"/>
    <dbReference type="STRING" id="595528.A0A0D2WRA3"/>
    <dbReference type="eggNOG" id="KOG1882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRA3"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRA3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="318" mass="34509" checksum="26E17A01A944692B" modified="2015-04-29" version="1">MGAWEPQSSAKCQAEITDKAEAAAAAAAHRHRVEATTITIATEAGAGAGAGVRRLHTRDVVETTALAPRGSRWEDDSGPRKHGSSRSSRFDDREDAGSSWGSSRGGDSRRGGRDHGDDANANPNTTAVLHTASADKFVFDASQIAPADGTGASGEAEKSVVQPNFALSGALAAETNTFNGVVLKYAEPLEARKPKKQWRLYPFKGEQSLDVIPLHTQSAYMFGRDRQVADIPLDHPSCSKQHAVIQYRQMPHERPDGTQVLRVKPYLIDLDSANGTTLNGKRIDPRRYYELLLKDSICFGLSSREYVLLHDQATEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS93</accession>
    <name>A0A0D2WS93_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347688.2">
        <property type="nucleotide sequence ID" value="XM_004347638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS93"/>
    <dbReference type="STRING" id="595528.A0A0D2WS93"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WS93"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS93"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="394"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="781" mass="85600" checksum="699D4E27AFE30DCF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSF5</accession>
    <name>A0A0D2WSF5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSF5"/>
    <dbReference type="STRING" id="595528.A0A0D2WSF5"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSF5"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSF5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="484" mass="51080" checksum="7547A95C686E9F0B" modified="2015-04-29" version="1">MASAEAKQILAAIQAQPGNNNCFDCNAFNPQWVSLSHATFVCLDCSGRHRGLGVHISFVRSVTMDKWSDQQLAKMKAGGNAAAREFLSSQPDWRNDASIEQKYNTMPAALYRDKLSAAAEGRSWNINSARQTVVVYGAPSATASRTASPAQSSLDNFYASSSNAASSTSLGSNSKHGSSGNMYSESAIQQSISGKDDFFKRKQSENAMRSSDLPPSQGGKYTGFGSSSSTSSGSSKSNNNGGEMFDDAWASFSTGWASFTAGASKLATSVSEQATKLGSAVQTNVIAPTSEKLHEGKLLDEVSSFASKVGAGMQSLWRDADRMLHNNGSDPSGSQQQQQQQQQQSQLSGDDDGWAGWGEPAPAPAPAPQAQLQAVSSNNVPRTNSASPATGSSFSGFGTSQAQDDDDDDDENPFAAPKVQRQQSGSSKPQQAGSFSSFGSTVPVKELMKQNAAAKAQQAPASTGWSDDWQDDDNAWESINSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTP5</accession>
    <name>A0A0D2WTP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-spondin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTP5"/>
    <dbReference type="InParanoid" id="A0A0D2WTP5"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTP5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254790" description="MACPF domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1326"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1682" mass="182080" checksum="563037C1CEFE59C4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU33</accession>
    <name>A0A0D2WU33_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU33"/>
    <dbReference type="STRING" id="595528.A0A0D2WU33"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU33"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU33"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051348">
        <property type="entry name" value="U-box_ubiquitin_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45647:SF139">
        <property type="entry name" value="OS02G0152300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="239"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="57"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="507" mass="56293" checksum="AA68E0CDFE2CB459" modified="2015-04-29" version="1">MDSLSWNQIGDVGAQAIAEAEHQQLRSELVIKDQELATNKQELATRDQALAARDQELQQLRFDLAAKDQKLATTEQELIAKSCWFAVKDQELTAKDQALATNKQELATKDQELQQLRSSLAAKDQALAAKDQELQQLRIDLAAKDQKLATTEQELIAKNQQLAVKAQELTAKDQALATNKQELATKDQELQQLCSNLQSALDRIGVLERNQPADGSFSNFDGPIPQVSLATLVAATNNFAADSLLGEGAFGRVYGASLPGPRVAIKKLSAESKQGTVEFKSELDSLSKFRHANIIAIMSYAEEGDERCLVYEFMPNGSVRDRLSRKNNTPPLTWSQRHRIAADVARGMHYVQTAFPDHVLFHLDLKTDNVLLDAHFNAKVSDFGLVRAAQHLDERSYLRTQNVQGTAAYMCPDFFDEGRMTIKTDVYAFGMILLELLTAVKPSNRLKGETRKALKNQKFMEMLDSALKPSDAERQSITEMVTLALECLDDIADDRPSFGSILVSLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU46</accession>
    <name>A0A0D2WU46_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345398.1">
        <property type="nucleotide sequence ID" value="XM_004345348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU46"/>
    <dbReference type="FunCoup" id="A0A0D2WU46">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU46"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU46"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU46"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="6">
        <location>
            <begin position="460"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="693" mass="78345" checksum="8CA8E444B81E5796" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV33</accession>
    <name>A0A0D2WV33_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344509.1">
        <property type="nucleotide sequence ID" value="XM_004344459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV33"/>
    <dbReference type="STRING" id="595528.A0A0D2WV33"/>
    <dbReference type="eggNOG" id="KOG4091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV33"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="3">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1092" mass="115324" checksum="908C66AB27219EE5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVB1</accession>
    <name>A0A0D2WVB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVB1"/>
    <dbReference type="FunCoup" id="A0A0D2WVB1">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVB1"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVB1"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVB1"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="337" mass="35604" checksum="DF6E7FF326A79363" modified="2015-04-29" version="1">MPVERNRVVVRVPATTANMGPGFDCIGMALGIFNELIVERSDAFAMEIIGEGQAELPRDASNLASYQALSLALRPRSGLLARSTTPTLSYVLKNAIPFARGLGSSSAAIVAGLLAGLTLAGHELSVQQDEELLNIAADLEGHPDNVAPCIYGGLQIGVHTGRRWMSTRVSVPHGLQAVLFVPDTPMETATARAVLLPTIQRSEAVFNIGRAAMLVHAFNTGRLDKLQEATRDALHQPQRSGIMPVLFPVIDAAIAAGAHGAFLSGAGSTILALTSGRRGDVYVQRSDERKEKEVSDAMLAAARAHNMPGKIYVTHPVELGAHVVSVEPADASNSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC4</accession>
    <name>A0A0D2WVC4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Z-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343783.1">
        <property type="nucleotide sequence ID" value="XM_004343733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVC4"/>
    <dbReference type="InParanoid" id="A0A0D2WVC4"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Z-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="425" mass="46246" checksum="BB52959F0EFD9790" modified="2015-04-29" version="1">MKTPPPLEQTALDFVLKNSGVDALAVAKQAKLVTQKDINPTLYALEKAGQIVRRETGSRPLWYGPEVYPPASPRVPVSAVASAAAAVSSPMPSPPPTPPSHRSPRRPQAALTSATSTLTPIQPARVDDLAPGVATTAVPAAHAALVDRDINKLRDMMTSDVRGAQAEKHWQSKYPQNLNNVELRTLADLKLLAKDLKPRVTGVGCKNDCLIKLIQQLFEREVQNGNVWFEPTKTTTLVNLGSKQFPGDYESSVALLIAKTLKEEAKANFWTSPSTTVEIDMITEWTKSNDVAFSCTIHEIKASCAPAKVLKALQQGARAALLVWTVAQAVYRVKTGAIHIKVNCCSCADVGPATDSPERERAIGQLPSKLYRRQTEGTAVGYKIDTRFTYSDEDTRKFLSSLPVVVPTELTLSFSIETDPIPMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXV4</accession>
    <name>A0A0D2WXV4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Golgi to ER traffic protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342754.1">
        <property type="nucleotide sequence ID" value="XM_004342705.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXV4"/>
    <dbReference type="FunCoup" id="A0A0D2WXV4">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXV4"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXV4"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE98140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32853" checksum="6C434B1990BBE7F2" modified="2015-04-29" version="1">MADRGGVTRVLAKLEKSIEAGDYYEAHQMYRSVYARYAAQNDFDSAILLVYTGSTLFFKHGQTGSAGDLAVLMLDAYTAQPTPLDEKSLARIAELFSGYKEDHATRDKLVRQSLKWSTAVGRNTRGDPSLHHLFGTAFWREHNYQLAESHLVLGTEASALSLAEMLLEWSQKGSPSELELFITRAVLKYLELGNLRDANVLFRTFTAQHPSIRNPPFRLPLLNFCHFLLATLERDAAPLFKMLREKYRPSLQRDASFDASLDAIGQCFFNIRSSSGVSSMPGISEMLRTMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY45</accession>
    <name>A0A0D2WY45_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342967.1">
        <property type="nucleotide sequence ID" value="XM_004342917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY45"/>
    <dbReference type="STRING" id="595528.A0A0D2WY45"/>
    <dbReference type="eggNOG" id="ENOG502SFWD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY45"/>
    <dbReference type="OrthoDB" id="10256774at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22671">
        <property type="entry name" value="FHA_APTX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="518"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="992" mass="106518" checksum="B03F2D4D47EE8A7C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY62</accession>
    <name>A0A0D2WY62_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_009212</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346389">
        <property type="protein sequence ID" value="KJE98330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY62"/>
    <dbReference type="InParanoid" id="A0A0D2WY62"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY62"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="360"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="837"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1138"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="1429"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1731"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1261"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE98330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1811" mass="201113" checksum="6486B93028CA5432" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY97</accession>
    <name>A0A0D2WY97_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SEC31B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343028.1">
        <property type="nucleotide sequence ID" value="XM_004342978.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WY97">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY97"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY97"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY97"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="852"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE97858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1308" mass="140328" checksum="4691F6FA742F66F7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYI2</accession>
    <name>A0A0D2WYI2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYI2"/>
    <dbReference type="STRING" id="595528.A0A0D2WYI2"/>
    <dbReference type="InParanoid" id="A0A0D2WYI2"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYI2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24660">
        <property type="entry name" value="PGAP1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266669" description="GPI inositol-deacylase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="740"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="12">
        <location>
            <begin position="82"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE98013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="901" mass="97642" checksum="1B715E382EE9A17E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X093</accession>
    <name>A0A0D2X093_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat containing protein 16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365138.2">
        <property type="nucleotide sequence ID" value="XM_004365081.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X093"/>
    <dbReference type="eggNOG" id="KOG4242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X093"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X093"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="2">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1708"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1813"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1867"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1896"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1975" mass="204661" checksum="82CAC6C17EC1C36F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0E3</accession>
    <name>A0A0D2X0E3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0E3"/>
    <dbReference type="InParanoid" id="A0A0D2X0E3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="68" mass="8054" checksum="FFB46C0588B357A1" modified="2015-04-29" version="1">MCCSGLRTAARFVSKLKRRRAQRCSLGKRHRHSSRSIRRPFRKRFGSSQPCLIQRQRTNTLPNAVRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0X8</accession>
    <name>A0A0D2X0X8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349778.2">
        <property type="nucleotide sequence ID" value="XM_004349728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0X8"/>
    <dbReference type="InParanoid" id="A0A0D2X0X8"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039701">
        <property type="entry name" value="HS1BP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14431">
        <property type="entry name" value="HCLS1-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14431:SF1">
        <property type="entry name" value="HCLS1-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="165"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="63997" checksum="0CAA304FA5828441" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X163</accession>
    <name>A0A0D2X163_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364464.2">
        <property type="nucleotide sequence ID" value="XM_004364407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X163"/>
    <dbReference type="FunCoup" id="A0A0D2X163">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X163"/>
    <dbReference type="InParanoid" id="A0A0D2X163"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X163"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF17">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="520"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="654"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="945"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118172" checksum="14DEE3CA207E0AE8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X167</accession>
    <name>A0A0D2X167_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_008527</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270108.1">
        <property type="nucleotide sequence ID" value="XM_011271806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X167"/>
    <dbReference type="FunCoup" id="A0A0D2X167">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X167"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X167"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X167"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE90279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="771" mass="87304" checksum="CC80DFC7881FCD46" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1C0</accession>
    <name>A0A0D2X1C0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1C0"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1C0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="870"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2127"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1413"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1553"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1806"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1877"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2405"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1423"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1570"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1626"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1814"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2411"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2437"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2507"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="2178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2575" mass="272276" checksum="BB5EF4E32CB0BA41" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1N4</accession>
    <name>A0A0D2X1N4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349050.2">
        <property type="nucleotide sequence ID" value="XM_004349000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1N4"/>
    <dbReference type="STRING" id="595528.A0A0D2X1N4"/>
    <dbReference type="InParanoid" id="A0A0D2X1N4"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="613"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125248" checksum="BCEAADC1F04E46D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Q9</accession>
    <name>A0A0D2X1Q9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349154.1">
        <property type="nucleotide sequence ID" value="XM_004349104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Q9"/>
    <dbReference type="FunCoup" id="A0A0D2X1Q9">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1Q9"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Q9"/>
    <dbReference type="OMA" id="VWKSFGD"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Q9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43509">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43509:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="282"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="445"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="667" mass="74882" checksum="2B110D1B6DAB332D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X325</accession>
    <name>A0A0D2X325_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348164.1">
        <property type="nucleotide sequence ID" value="XM_004348114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X325"/>
    <dbReference type="InParanoid" id="A0A0D2X325"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="309" mass="33751" checksum="D3B64908D3809EB9" modified="2015-04-29" version="1">MSLARQKGPAIPAQKLPNIVASTAIVRPGAEAGGSNAQPMDDREDDSRFSSEPQWKAALRRSKKEKDFESKKKAAAEAERLAAIPIWKRHIMEVKERKSSSPNGSISMTPQQVAAMQQIHDPDAPTSSAAAVSAANASWMDNLASRDTYRPTHSTNRDFSANSARFNTLERGNISALGNRHIPDAAPLVPKALQMNAQPAPAPVVSTKPKKNLSVSFFEEENEIPYVEFEGEIEFNQELATEMDTEPMNEGNADDNEDQILSTLRVAALARPDQATMALNVAGRQITTTARDEITDVTNLEDDLAAMIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3G2</accession>
    <name>A0A0D2X3G2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3G2"/>
    <dbReference type="STRING" id="595528.A0A0D2X3G2"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3G2"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3G2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="455" mass="48235" checksum="12109BD62D1B9593" modified="2015-04-29" version="1">MNTLAGGIIVGAALSHMLPTSEDSIDDYFVDSATGVTTNTYPYAGLIAGGSLMILIVIDKTALSRYDKHGNQVGHSHSAPDVPGENGHEEGSSGDSDDSDDDDEEEGAAGGSGTVRHRRRANHHHHTHHHHNIYHSNEEVLPYDPILTRATANGSIVSTVIRKVGRVRRHSISSTSQAVNLLEESTISCSVTCDPNPDCSTPNMTQRLSSSQLASSDSTSVPANGAAHAAVQVPSQPLLGAASSGDAQRTSYGSVADPRSPDQTPLLRNKQDSKLAKKHMSPLEIRAYLFTIALSVHSLFEGLGMGAETTESGLLSLIVAVVAHKAIEAFSLGVSVYFAKMNRTRSLCILIGYSLVTPVGIAVGMGAAQSAQGPVRDLIEGILTAVAAGSFLYISLIELIPSELQSNAGVPPPPPRKSIQHDSPQPWLTRKKALWIKILCLVFGWGIMALIAEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3J5</accession>
    <name>A0A0D2X3J5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_005062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the origin recognition complex (ORC) that binds origins of replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3J5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3J5"/>
    <dbReference type="eggNOG" id="KOG2228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3J5"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3J5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003506">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007858">
        <property type="entry name" value="ORC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="423" mass="46819" checksum="496055C1B8E081C9" modified="2015-04-29" version="1">MANHTSTAEIIARVRLQLSDQSPRTLYGVTPQLEQLEKLMRRTVANLESNSALLIGPRGSGKSAAVNACIAAITADFGSDAFAVVRLNGLIHTDDRLALRDIASQLKVQRALETGNLSSFAAALAFILETLRNGSRQSQPLIVILDEFDQFAHHAKQTLLYNLFDLVQSAEAPMIVLGLSCRLDVIELLEKRVKSRFSHRQIHFLHNFGFDEYLSIARNSLLIAGAEHDAAISAWNAQVAEAMNDRSLVAALQVQFDLSKDPRVISTVLVCILNSALTASATGRLQASSVVSIIQAQFVDAKALVLQGLSTLELCLMIAINHVQVKVGVLEPFNFEMVYEEYKAFANSNVHVIDFFSKPVSLKAFEHLQAIELIKPVHPNAFHVPKEYRMMRMMVEPAQIVDAVTRFQDCSTAVRRWGSQWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X440</accession>
    <name>A0A0D2X440_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell cycle checkpoint control protein RAD9A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA repair exonuclease rad9 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X440"/>
    <dbReference type="FunCoup" id="A0A0D2X440">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X440"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X440"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X440"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="475" mass="51777" checksum="D427019E0150C080" modified="2015-04-29" version="1">MQCVVPSRSLKAFGRAVHCCAKIGEEIYLEAQANQLLVRTVSLSRAAFACFSFAPQFFDKYRTMPIAGLAVNEQSLLKCKVLAKSCQHIFRSLTNIEKTVDHCDISLDLDESRLVFRLFCKHGITKTHYLRFSECDTLQAIYGTEHCVNQIACPGAVLNDSVVLFPVNLEEMTISVTDTELRLASYTEDLVDPKKVLHTEMVIQKDEFELFAIGLPADITFCLKEFKAILTFCDTLNEAMQIHFDNAGKPIILSVATDMFKAELVLATLLDPMNSSTTSSQQVPSSASQQQHFHPQSTPQHQSTPTIKSSPKHEYSSQQSASSHGPTSTGQLFGSGRSNDSQRPSHHTSSHMQVDHATTWVAPQPTPQQSPQRNHVAASGLLSSAFGSHHGADRMSPNIMPTLGSSIPPPATSSSLPRIGMQPVAVGGGGGADLAGEARAAAAAGVLPLPWTTIVRMTSMMMMTSILMLLRHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4L7</accession>
    <name>A0A0D2X4L7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Syntaxin 1.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_006622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344243.1">
        <property type="nucleotide sequence ID" value="XM_004344193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4L7"/>
    <dbReference type="FunCoup" id="A0A0D2X4L7">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4L7"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4L7"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4L7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000022">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000011">
        <property type="entry name" value="Syntaxin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="324" mass="36665" checksum="CFD2EA0E0F6362E2" modified="2015-04-29" version="1">MRNRLAELQSAAAESPEPNPFALDEPDVPSDGQEGIAMQGMNGGTSPPDGYLSNATETDDEQFMAEFFAMVSDVRRLMADIEYKIQSIETEHGQALAAISQKQSQKSSEQLEKLMQEVQVLANQVRKKLKEMDKDIASNAGSQLHDAGTRIKESQKSILSRKFVKLMNEYNEIQTQYKQKYRDRVKRQLKIVKPGATAEEVNQVLDSDRDPGAIFANEIMSHAEAQQALEDIQDRHKDIVKLEKSIRELHELFLDMAILVEQQGEMIDRIEFNVGQAADHVAESKKELKHAARYQGKARRKKIMIVILLIIAILIIILPSILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4M7</accession>
    <name>A0A0D2X4M7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GS3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344291.1">
        <property type="nucleotide sequence ID" value="XM_004344241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4M7"/>
    <dbReference type="FunCoup" id="A0A0D2X4M7">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4M7"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4M7"/>
    <dbReference type="OMA" id="FTWMEQW"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4M7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="571" mass="63670" checksum="DB95C28BF55DF83E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Q7</accession>
    <name>A0A0D2X4Q7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344422.2">
        <property type="nucleotide sequence ID" value="XM_004344372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Q7"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Q7"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Q7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37989" checksum="9723C76C819CC617" modified="2015-04-29" version="1">MLSYERMNQRQRDLYDQVKNASGELSLDRKQMHQVAAKVIAEALKVNTTLTVLGLDGNQIGNVGARAIAEALKVNMGVTLLGLQQNQIGDAGAQAIAEALKVNTTLTQFYLGRNEIGDVGAQAIAEALKVNKTLTRLDFTKNYIGSVAAQALDEARRVNGTLTSLHIDNQINPLALSLLPRLATAEDLQTVFHLLIRGPELQDQSASLPALPAELAERILDEACYWQGVLQTMYTGGPIVTLPQGADGSSIRVKAIHALCDRSEGFDVTDNRVFELIVYDEQGNVQLESAVHPTLLDSTVEFVTLCPASTPIIRQMREEWQVQVRPSGSVYDLRMAWFYVGYVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4R0</accession>
    <name>A0A0D2X4R0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344435.1">
        <property type="nucleotide sequence ID" value="XM_004344385.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4R0"/>
    <dbReference type="FunCoup" id="A0A0D2X4R0">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4R0"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4R0"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4R0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="216" mass="24120" checksum="B0C7B6E7DC94036B" modified="2015-04-29" version="1">MSKISRESLRESVQLIIKGSAEDKRKFLETIELQVGLKNIDPNKDKRFSGSIKLPVIPRPKMKVCILGDQQHLDQAQAAGLPTMSVDDLKKMNKNKKLIKKMAKSYDAFLASDSVIKQIPRLLGPGLNKAGKFPTLINHTDDLVAKVAETKATIKFQMKKVLCLGVAVGNIGMTEDELVSNINISINFLVSLLKKNWQNVRSIYIKSSMGKPQRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4V7</accession>
    <name>A0A0D2X4V7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343728.1">
        <property type="nucleotide sequence ID" value="XM_004343678.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4V7"/>
    <dbReference type="STRING" id="595528.A0A0D2X4V7"/>
    <dbReference type="InParanoid" id="A0A0D2X4V7"/>
    <dbReference type="OMA" id="HGSHTHE"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="388" mass="42895" checksum="4201EA6C68709AF9" modified="2015-04-29" version="1">MPPRRRRVELDDDDDDDNDEERAVASDQDEARERDDDDQDDVDDEEDQDDDQDDQDDDNERPARVTRGRGRGRGRGRGRGRPPKNQTQGIGSKRGQAEQRSTKAKSARGSGGSSGTTRASRGGVKRARLESDDDEDEDDEDEDEEEDDDDDDDDEMEEDDDEDEDENISGSSDDDDAEHEQEDSTKLDEDQGKRSRKAPGKASAGIDDLDAPDSEEEWLQALEAGRLNARGQLEPSNSTIRGSSTRGAALLLKDDDSVADEVEVQATQTEPSSSSSATRRSAGDTNLLPALSAPVGRPRKAPATLPTEEDALRKSEKLRKDKLRMAKKAEDEKARTVQRLLGRQVTPVAQKEEPVKKDPYAITMTEPHTRIVISAKGTLISYSEGLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5A3</accession>
    <name>A0A0D2X5A3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAMK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5A3"/>
    <dbReference type="STRING" id="595528.A0A0D2X5A3"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5A3"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5A3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="516"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="683"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="973" mass="104811" checksum="E893EB9096CB59A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5U0</accession>
    <name>A0A0D2X5U0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346413">
        <property type="protein sequence ID" value="KJE98394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5U0"/>
    <dbReference type="STRING" id="595528.A0A0D2X5U0"/>
    <dbReference type="eggNOG" id="ENOG502S7UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5U0"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5U0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="52"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="395" mass="42686" checksum="047F0648389D84B5" modified="2015-04-29" version="1">MDLAKLSVELEVVDLQNELSASHTRQESDLPTKTVALEQLELDARMASARATINMPGSGVTSYKNIGMLGFGYHIFKGNPLPSSGVDPGFTLPVLKVDYSMRRMTADGSTMLPDRVAVIPYASAQFDSRSHLVTTSSEYAESLEVDVSIETSFSFSALVEGGGAKFSASNDYKQASEMHQSSESVSITTIGTVLTYVAEFLDDTPPLADHVIEMFNALPPPACCDGLVLPSHAGVSKDRSACTAIHANCGDLYLRFLDKVGTHTLIGVHMGGKSIRVYTMAQTEFESSVEQSDAFKSSLSLSSSGIESSSIDTSLSINKQSSLKQAVKDRTESRRETFMGGDPTAGTNDPEDPTNMDGDKEWSTTVSKNPVPIKYECECQRRTQVHRMTTSTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0X8</accession>
    <name>A0A0D2U0X8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365336.2">
        <property type="nucleotide sequence ID" value="XM_004365279.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0X8"/>
    <dbReference type="STRING" id="595528.A0A0D2U0X8"/>
    <dbReference type="eggNOG" id="ENOG502QS8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0X8"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U0X8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113340" checksum="FCB5BDF66ACB56C1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1V6</accession>
    <name>A0A0D2U1V6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_009328</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1V6"/>
    <dbReference type="FunCoup" id="A0A0D2U1V6">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U1V6"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1V6"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1V6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="173"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="511" mass="58332" checksum="19F5E39175A72676" modified="2015-04-29" version="1">MDPESSPSLDLSISQAPGRRKRGGAFRQQHGHERGDERRSNSAIWLSRDRVWSSCATLVEAYKDDKVDFELIKRHFVSEGRLSEDLALRILREGTAVLRAEETLLNIDAPITVCGDIHGQFFDLMKLFEVGGHPSTTRYLFLGDYVDRGYFSIECVLYLWALKTTFKDSLFLLRGNHECRHLTEYFTFKQECKYKYSETVYEACMEAFDCLPLAAVMNGQFLCVHGGLSPEINTLDDIRKIDRIREPPAYGPMCDLLWADPLEDFGEEKDDDFYVHNHVRGCSFFYSYHAACAFLEKNNLLSIIRAHEAQDAGYRMYKKSTTTGFPSVITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVIAMLMAMLNICSDEELADDDTSEEGAAEKAARREAIKNKIMAVGKMARLFSVLREESESILTLKGLTPNQQLPQGILSKGKQGIKSAITTFAEAKEVDRENERMPPRKDSTEQDLARNMSRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3E9</accession>
    <name>A0A0D2U3E9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Klhdc4-prov protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366028.2">
        <property type="nucleotide sequence ID" value="XM_004365971.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3E9"/>
    <dbReference type="STRING" id="595528.A0A0D2U3E9"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3E9"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U3E9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="684" mass="74502" checksum="F39BB032A9C02777" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3J6</accession>
    <name>A0A0D2U3J6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349745.2">
        <property type="nucleotide sequence ID" value="XM_004349695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3J6"/>
    <dbReference type="STRING" id="595528.A0A0D2U3J6"/>
    <dbReference type="InParanoid" id="A0A0D2U3J6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="527" mass="58087" checksum="9B8B3EDE933427CA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U416</accession>
    <name>A0A0D2U416_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349846.1">
        <property type="nucleotide sequence ID" value="XM_004349796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U416"/>
    <dbReference type="FunCoup" id="A0A0D2U416">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U416"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U416"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U416"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000001">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="256" mass="29166" checksum="7D4189CC0FB68DBC" modified="2015-04-29" version="1">MFTSKLKTAQKDAVGRFMSLALVSEAIAIQFLERASWKLEPALDAFYNSPEARKQKAPRVDDKKLAAFFEKYKDDPTEDVIGPAGMEKFCEDLEIDPSNILMLIIAWKLNAATMGYFTRAEFTTGLTNIGVDTPEKLKEQFPALRAVLDNEFSFRDLYIYTFNFGRDPTQKGLALDSAIALWQLVLEGRFKFLSLWCTFLKENHSRTISKDTWNLLLDFASTINDTMSNYDSEGAWPVLIDEFVEYAQTELKQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5X6</accession>
    <name>A0A0D2U5X6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5X6"/>
    <dbReference type="InParanoid" id="A0A0D2U5X6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="162" mass="17785" checksum="EE47979BF4AF0E1F" modified="2015-04-29" version="1">MNTTLNSTPSAAPSIALRRRPASAFGPTAALAPARPLSVMRPANGLHVDSSLSDLTEQELFRRTKYNTLRNSQVKVTLYRNGETMDPRLGVRPRPAPVATSEPRKQHIKWAEELTNDEPAAPSANKQRRRSSLKPLGSGKRCPFVDQVPEPVVIRPLASSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U623</accession>
    <name>A0A0D2U623_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364737.1">
        <property type="nucleotide sequence ID" value="XM_004364680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U623"/>
    <dbReference type="FunCoup" id="A0A0D2U623">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U623"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U623"/>
    <dbReference type="OMA" id="LKGRCAF"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U623"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="576" mass="62727" checksum="B64310B969E61A70" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U626</accession>
    <name>A0A0D2U626_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364742.2">
        <property type="nucleotide sequence ID" value="XM_004364685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U626"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U626"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U626"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17399">
        <property type="entry name" value="MFS_MFSD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="463" mass="49833" checksum="CA0783B8D9CBB2BF" modified="2015-04-29" version="1">MSTHNNYNALENTPSAVSIHQQNGVGAHKVYKRRWLMLTVVCLLNIVNAAQWIQYAPIADTVKRYYDVSSTWVNMLSQIFMILYIPFGFMASWALDTRGLRYACVLGAVLNAVGAFIKYMANFVEITPSADPNIMFAVVMVGQFFAAAAQPFILGAPTMLAAVWFSDSERATANMLASVANPIGIAAANVLSPAIVDTTEPWTINTMHWMMMIPAGIVAVITIVLMRAKPPTPPSLSAATPSDPFFVGLKKVATNKSYLLLLVSFGVGLGIFNALSTLLEQIVHPQGYTDDDAGIFGAALIGAGLVGAGISGPLIDKTKAYRPVLRGCFILATASFVGFALSARPDEYVLVAVTCGLIGFFCFPLLPTCLELAVEVTYPVSEGTSASFMWMAGQALGVVFIFIMDAMRTGAEEDMTNALWFAVGVVGATLIPVFLFKGEYRRLNMERETKANASSGLNGDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U647</accession>
    <name>A0A0D2U647_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome 26S non-ATPase subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364758.1">
        <property type="nucleotide sequence ID" value="XM_004364701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U647"/>
    <dbReference type="FunCoup" id="A0A0D2U647">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U647"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U647"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U647"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000013">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="362" mass="39461" checksum="1288246F9238065F" modified="2015-04-29" version="1">MAPTRTTKDVASSAKDKPIEDVPASSASASGSGADGANDLTVPAPLVSATAHLPKSVIVHPLVLLSAVDHFYRVSKDSRKRVVGILLGQRTGDTIDVSNSFAVPFEEDERDPSVWFCDHNFIESMHHMYKRIAAKEHIVGWYHTGPKLRTNDLAINELLQRFVPHPLLVIIDVEPKELGLPTSAYMTVEEIHSDGSPTSKTFEHIASEIQAEEAEEVGVEHLLRDVKSSTAGTLSERITNQLASLRSLLSHLSDIHGYLDKVATGALPMNHQITYQLQDIFNLLPNVTVDELVSAISVETNDQMLVVYVSSLVRAIIALHNLISNKLANRDAEKKTEQSIARSLEDTISSGGKTKDGPTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6I9</accession>
    <name>A0A0D2U6I9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_002026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348776.1">
        <property type="nucleotide sequence ID" value="XM_004348726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6I9"/>
    <dbReference type="FunCoup" id="A0A0D2U6I9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U6I9"/>
    <dbReference type="InParanoid" id="A0A0D2U6I9"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6I9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="174"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="402" mass="42336" checksum="2B603567F245AE52" modified="2015-04-29" version="1">MDAILRGGAAATKAVSSAAAAAITGAGTDAQAGSGAGAAAEAGWLSYWTSDAPRDTSAAGSSSMLGFASSSSSSSSSSAVVPFLAGMIVGQTLLIATILTLLWLLVLRNNPRQPSSGSGSASASGSTSASAGSITTDANGKASKSPIRVRVSRQSEQAFFKALHQQTFAKTKATNETCLWLNVVLARIYHDVTSSDAVMDRLLRFLKTSLNSARNPPFLGPISVESLVLGDAIPVIENVVVNTDYNPSGSQPLDLRAVFTIDFQGEIALTCNTSLVLNWPVDGLASTSVTATVRLTSVRAKVQLHLPCPIRSTDMPEAPENMFSFAFVEEPQFSFTTDTAIGQRVHLSSEKLASIITTNVRKALINKCVLPAQIRFQLFSELVEQRRATAEQRARAQPPVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6N4</accession>
    <name>A0A0D2U6N4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6N4"/>
    <dbReference type="eggNOG" id="ENOG502SFFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6N4"/>
    <dbReference type="OrthoDB" id="10275276at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6N4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="462" mass="49523" checksum="08BC5857ABFAB589" modified="2015-04-29" version="1">MLRTPRSKGSPPRTAPARNRPSGFVLVLPMAFFAAILFLLANARGAFAANGTPVGIHFDIEPQSLPNWNDPTYQASCVQQQLQLADKMKAAWAYEGAPIPMTYDIPVWYDALTTTYNGETKSAFKLLSDRMPRVNMMDFRDTYDTILQNCVPQCTYLGSLGKECAVSVESKDIGLDSATFYEEGPAVMHNILGQVEATLKTQFPTAFKGMGVHEYAALLNIPPSSTPYNSGRQDAYLYLWQFDLGHSETDRQQLWTFLDQWSPYWNFHTMLFEAEDLLLYDPAALQAFIKMLDARGIKTELTFGFASWVLQPFHSYVVNLVAASAWYYRIVSTGGTIQPGQLFPGAGSGPGISTSTSTSTSTSSSTSTSTSTSTSTSTSTSTETGTGTSTSTSTSTSTSTSTSTSTGTGTGTGTGTGTGTGTGSGKGDDFVPATSDAASTMASSALVIAALMCMVTVRWIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6Q0</accession>
    <name>A0A0D2U6Q0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348838.1">
        <property type="nucleotide sequence ID" value="XM_004348788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6Q0"/>
    <dbReference type="STRING" id="595528.A0A0D2U6Q0"/>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6Q0"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyl-gamma-glutamyl-phosphate reductase dimerisation" evidence="1">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="127" mass="13962" checksum="8D3A1A626D566123" modified="2015-04-29" version="1">MSGWTPYRRSAVHSAPHVAPFFQGITLTTDIQLDVKLTREQVVQRFQDMFGKEPLIEIVAQKDAVPVVKDNAQKHFVRLGGFAVDPATNRVVVVATLDNLLKGAATQALQNINIALGLRELDGIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8L6</accession>
    <name>A0A0D2U8L6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349312.1">
        <property type="nucleotide sequence ID" value="XM_004349262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8L6"/>
    <dbReference type="InParanoid" id="A0A0D2U8L6"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="609" mass="65040" checksum="F1286B8F5992524F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCZ1</accession>
    <name>A0A0D2UCZ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCZ1"/>
    <dbReference type="FunCoup" id="A0A0D2UCZ1">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UCZ1"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCZ1"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="909" mass="100271" checksum="E4D1E2F3BBE4C210" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHQ0</accession>
    <name>A0A0D2UHQ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346908.1">
        <property type="nucleotide sequence ID" value="XM_004346858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHQ0"/>
    <dbReference type="InParanoid" id="A0A0D2UHQ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="501" mass="54131" checksum="FF3D5386BAF03FD6" modified="2015-04-29" version="1">MEQEQEGNPAHLQDDLTPNQEQDENNHTDEQDNVGPDPLQHLFSHKLPTLSNHELPNLPAALNNEPKSGEASQCAAVPRTKRKGQKARRHAKRLKAVPPPPESNPDSLASPISEAAQQPVPLDVHQCAEHVGVEPPVAEQPERASPIDESMCFNPQFCYAILLSLDYPVLDEYPKGFQPFNGAVFLFRTGTNRRWRGGLNHFEKGYKTADGGTIYRSSQPGGLFRLVYPVAKNIVLIRYSTQTPTAEAASASSRSIGTNEPSAIDGASSSKHQAGTGKSRTDQSVSKSKNRSAKSPIGQAASSSSSQLGMGIVESPAHVAAPSKPAASTSTKARRLQSTSRAFTKRPVTPETEPEDESDVEDFEDDAESTVRSYGYTGPSPASTVGSEVDAENQNDWAIGVAVSAVRCGLCPSQGYQPLPNDMLPSPAQNASTAQDWETAMAPLFDMIPSPAWNENVDVGQAGNEWTFDLLRLNEQDLENDPAIIYVAATVAWIASELRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI25</accession>
    <name>A0A0D2UI25_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI25"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UI25"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="768" mass="76953" checksum="618AFB37B1B57D29" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM29</accession>
    <name>A0A0D2UM29_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin-protein ligase PPIL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CYC4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Probable inactive peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAOG_006485</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1. Interacts with isoform 2 of BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345234.2">
        <property type="nucleotide sequence ID" value="XM_004345184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM29"/>
    <dbReference type="FunCoup" id="A0A0D2UM29">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UM29"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UM29"/>
    <dbReference type="OrthoDB" id="30774at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UM29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000018">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="22">
        <location>
            <begin position="295"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="472"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJE96116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="568" mass="62043" checksum="E7DBE535D6456508" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UML4</accession>
    <name>A0A0D2UML4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UML4"/>
    <dbReference type="STRING" id="595528.A0A0D2UML4"/>
    <dbReference type="eggNOG" id="KOG3384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UML4"/>
    <dbReference type="OrthoDB" id="1910009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UML4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF6">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253594" description="Selenoprotein F" evidence="7">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="8">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE96286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="17936" checksum="444E2C8E6C8B0F79" modified="2015-04-29" version="1">MHIRSFALSVLLLALTIAAERANAASPSSSSSSSSSCRDLGFSSSLLASSCSSCDNLDTFSLGFMKSDCLRCCQSEMSSEERIMSAKSGRIHIEVCQCNWARYPDIKDFITQDAVNFPKLEVQYKSGVLPQLVATNSAGQEVDRKPIGAWKRDVLKEYLTTVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGK4</accession>
    <name>A0A0D2VGK4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGK4"/>
    <dbReference type="InParanoid" id="A0A0D2VGK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="206" mass="22609" checksum="E9874A18E303AFF0" modified="2015-04-29" version="1">MPRTEDMQHGGEMRAPAGVRVGSGIVGRVGLQQLIRFGVAGVDVLDDDALVLPLGIGQELGVPVNLKDPAGGERFDHTEILWRVDVLFQPLGHWQNHLLANPSHRLARLGDLERAAHDGVRHFDQALVANIVVQIVDERPEDALKLGVEEGVRARVEERVVKVERDIDEPVTLAALGQLEHELVNLLAQAQSRRVLSGEQRLETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIX5</accession>
    <name>A0A0D2VIX5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349860.2">
        <property type="nucleotide sequence ID" value="XM_004349810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIX5"/>
    <dbReference type="eggNOG" id="ENOG502RY6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VIX5"/>
    <dbReference type="OrthoDB" id="2580091at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VIX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08357">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="68"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="206" mass="21995" checksum="D8F10AE3270D2B4B" modified="2015-04-29" version="1">MLGSLSNIVSSAGLNGCRLNSTRLAMAGRMGLSFATGLAANSARCASTGAAAGAGAAAAAAAAAAALQPFHLAIPVNDLAAARAFYGGVLNLKEGRSSAGWQDYDFYGHQLVIHQVTRDYRGNDYFNPVDGDQVPIAHFGVVLNVAQFHDLAQRLQKANTEFLLKPHVRFQGLKGEQWTMFFKDVSGNNLEFKALTNPDDLFTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJV4</accession>
    <name>A0A0D2VJV4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJV4"/>
    <dbReference type="STRING" id="595528.A0A0D2VJV4"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJV4"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="10">
        <location>
            <begin position="680"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="770"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="910"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122202" checksum="78290A49FD6BB372" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK15</accession>
    <name>A0A0D2VK15_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4442 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364552.2">
        <property type="nucleotide sequence ID" value="XM_004364495.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK15"/>
    <dbReference type="eggNOG" id="ENOG502S44Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VK15"/>
    <dbReference type="OrthoDB" id="10255641at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="19660" checksum="FBFE18A793AF388B" modified="2015-04-29" version="1">MAASNQMTRAIAQLGNLPAFMRQWATSTAFGRTVKFAGTAGIQFESLKPGEVTCSIANKSHVQNHIGGVHAAAMALLAETATGFVVGISLPDDKLPLLKSMHVDYTKRAAGGLRAVATLSPEQIEQLKTQPKGAVTVPVVVTDKEGKEPISAEFVWAWIPKPVKGAAAAAASKASSAPADASAAKPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKR2</accession>
    <name>A0A0D2VKR2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKR2"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKR2"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253672" evidence="3">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="483" mass="53033" checksum="2E588F373BDCBE7A" modified="2015-04-29" version="1">MLTVLTVLTALTVSSLITHPYSVWSGLGALLDPTEGSLGGFTIGMPISSVIGYLNTKLRDEIPQCELIYSASNPLALHISINLPATGLRLRIDAVSQRLVVIEVLDMFALTLRFAGKIISGPRTPLTFVNVQKHFGPTSPGRYDDARQQYIHAYSGFALYFAIPSKHQAFVKNSATFGMFPDGTTPVAAKICLYHGKWDRPTLPPLPLGSLYMQKVVVDVRHGLHFPLERTVVRFGDTCQDVFSELGAPNHVFHKADVRAIVATNSRQGSDSDYFYNYFDRGLDVLFDAQTHSVKKFILHCNFPGHFDFNRYSKCNFRLLGSSLVARHSRSAVGPASKQPASFGELDGEPPTEVLVDVSGPVSTSSKRNRDADSSRGSAEAGVHENPFNVDLASVLADDPSENDPYETVKAQECRVIHPNMTWDAVQHLIGRPRGKPAVYNKEVTLNPFGTVQFHGFNGAIFEIMNNNHIASVTVFRPAVATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM23</accession>
    <name>A0A0D2VM23_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM23"/>
    <dbReference type="STRING" id="595528.A0A0D2VM23"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM23"/>
    <dbReference type="OrthoDB" id="2105857at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM23"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="44616" checksum="499D202D63F6E54F" modified="2015-04-29" version="1">MSASAFTDLTKLTQLSLDNTPITSISANAFAGLSALTQMFLYQTQITSISASAFADLRSLQKLYLYGNRITSISANAFTGLTKLAYLDLSYNQITSISANAFADLSSLTDLRLYFNQMSSLAANTFTGLSALTQLSLLNNQITAISANAFTGLNALKLLYLHNNLITTIAANSFAGLPSLTVLQVYNNTITSISANAFTGLSALTMFLLNYNQITSIPASAFTELTTLQVLALDNNPFTTLPPGLFQGLPNNLYLSAPDFYYYKPLYPNNFTFGGNTVAPPSTYGSASVPYRKFRLDWTCYDGYGMLSGSCVPFPSIASASAASLVSAVSASVASLDAASSASMATEASASAASASSVWQTSAASAASASNAPKDSSDASSGPIIGGVIGGVFALLLLAALFVALRRRRSRKPFATTSAGYHSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMM6</accession>
    <name>A0A0D2VMM6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_002567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMM6"/>
    <dbReference type="STRING" id="595528.A0A0D2VMM6"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMM6"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="242" mass="27153" checksum="D797CEE7970D4967" modified="2015-04-29" version="1">MATQYCMIRNGKKSARLSLCFTPASDPARIKQMSLSTLASVKATLDVLLASANSTPAVADLLAIVKGFRNGLVYGAKIRAPHAFVMTFLFGRGSLKNKATAIFKATYTHSRNLSTFVLIYKSLLAVLKRLQGVRHTTHPFIAAFIGGWYVFGENNNINSQINMYLLSRIIFGLAKLAVEKGYIPKPQNDPFPLFAALVWGIVLWLFEQEKHTLQPSLQASMTYLYHDSNHWTNLKNFLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VN62</accession>
    <name>A0A0D2VN62_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VN62"/>
    <dbReference type="STRING" id="595528.A0A0D2VN62"/>
    <dbReference type="eggNOG" id="KOG4642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VN62"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VN62"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254360" description="E3 ubiquitin-protein ligase CHIP" evidence="11">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="217"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="33922" checksum="E0FDB4F6A42910BC" modified="2015-04-29" version="1">MLLLSYSALFSLALSIVQHLAMSEANKAKADAQRAEGNRHFMEERFDEAIRRYNEAMALDPDNAKLYTNRSLCYIKLKQWDEAASDARTAIRLDKSSVKAHYYLGQGLIALGNDEEAGDVLKLATDLAVQQRLDYGDEIWSLCRKVKQRVWDKKESQRILQEISLSEYLRKLVLKDKEEQLASNPRNAAKITEQFEDKLSQVTDLFKQIDERRRRRMVPDYLVGKISCDLLVDPVITPSGITYERYCIEEHLRANGGYDPVTRAKLKESQLVPNLALKDATEDFLRLNPWAYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNP0</accession>
    <name>A0A0D2VNP0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HutD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363846.1">
        <property type="nucleotide sequence ID" value="XM_004363789.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNP0"/>
    <dbReference type="eggNOG" id="ENOG502SEIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNP0"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNP0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20293">
        <property type="entry name" value="cupin_HutD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943">
        <property type="entry name" value="PROTEIN VES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943:SF1">
        <property type="entry name" value="PROTEIN VES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23845" checksum="BEBECFA848752609" modified="2015-04-29" version="1">MTLRFLAQSDYRTMPWKNGLGTTTELAVSPAGASIDSFVWRISAAQVGAAGPFSSFLGVARTLLQTSGTPMTITCTAKDEDASLPRTIWNHTMQWLQPITFHGEEQVGCTRLDGVATDFNVMTRRAQCQSTTSVLELISGGYFSRVVPGATTCFVHALSGEIAVQVVSCSVGLVPTTHPSVCVRSHESAVLEPSAGTTKDSIVLEVHCAQHARFILVELTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNV0</accession>
    <name>A0A0D2VNV0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270274.1">
        <property type="nucleotide sequence ID" value="XM_011271972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNV0"/>
    <dbReference type="STRING" id="595528.A0A0D2VNV0"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNV0"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNV0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="148"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="55278" checksum="85E94156E9D6C17F" modified="2015-04-29" version="1">MAEDSTVESAIAAAALADSHKKEGNALYHAQDYVGAVLKYQAAVDAGPPREALPMLYQNMSAAKYQLKQYAESIEDATKAIMIDPTFLKAHLRRGKALAALGNWHQARNAYAAAIAVTPNSTEAQIGRIEAEQALVAQYYKPYNETMTNAQVRYINPTRGKGVVTLKELQYGTEVFHEAPVVSHRFVGAEENSAIPACSHCLQTRLTPDMMGPFAVLHSEVYPSGTPSFLSCEKCFVPYEQYCSAKCRTQAWDDYHSVFCAKDRELAKIHPITELYALCRKHNRTNPLIIARAFAMSLTGVTSGRFSNMQDTFQRFGNFIASEEQTPHDAEEFALILNAFSPPHRKLMEIVLTIQNFRMLDGAIMRNAQRLNPVSDLHAMIDRLAQIDAHKLAAVLGKIGFKIPQLPGLRMSTPMRSLTVSGSGLFEIGNTMNHSCQPNVVSMTRATDFTLSVVAVATIPVNTEVCISYIDTDLPKAKRQAALEELYYFSCSCAKCQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPB7</accession>
    <name>A0A0D2VPB7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_003293</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364132.1">
        <property type="nucleotide sequence ID" value="XM_004364075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPB7"/>
    <dbReference type="STRING" id="595528.A0A0D2VPB7"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPB7"/>
    <dbReference type="OMA" id="PIEDAWE"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPB7"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24814">
        <property type="entry name" value="WD40_Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE92292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="500" mass="53672" checksum="FD3AFC5839E17A8C" modified="2015-04-29" version="1">MSLVCGLSGEAPEEPVVSRVSGGIFERRLILKYIAENGRDPLTEEPLGEHDLIAVKVPKTVRPRPPSATSIPALLKTLQDEWDALMLETFKLKQHYDQSQKELTHTLYQHDAACRVIARLTRERDAARQALANVQVSSHASNAGASAMDTEGDAAAAANAGSTTLPSQVVTAMQEASKPLSDARRGRKKPAGLTSQDAIAQFQQTEARSGIHSASQPGILALDVHAADPFRVVTGGADKTAKLFDRSSGQVTGTLSGHKGAVKSVLFHPSSDVVVTGSADRTVRVWTSSNESCQHVIQAHTKEVTSVTLQPTGRYVVSSGLDGKWAFSDIETGATYAKQHDPQSSGLTTAQFHPDGLILATGSVDGVVRIWDANEMTNVLNFSEHTAPITSVVFSENGYYMASAAQDRTVRLWDLRAASPQSIQQMQVEDTVHALAFDLSGTYLATAGPDIRVFLAKQWKQIAQFTTPTATSTAIKFGPNASFLTTAGMDRHLRVFSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQX8</accession>
    <name>A0A0D2VQX8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQX8"/>
    <dbReference type="InParanoid" id="A0A0D2VQX8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="84" mass="9120" checksum="E878467ED5605450" modified="2015-04-29" version="1">MSSSRSIAPPTGTGDNSNDAAVPEDLGEEQALAKALEALDPNMAIALSHLSKQLASFKKEIKSDLTDMRCDFGRQLDHTRKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQZ3</accession>
    <name>A0A0D2VQZ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQZ3"/>
    <dbReference type="STRING" id="595528.A0A0D2VQZ3"/>
    <dbReference type="InParanoid" id="A0A0D2VQZ3"/>
    <dbReference type="OrthoDB" id="1416801at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQZ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253796" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="39908" checksum="8FB98392ABF320FE" modified="2015-04-29" version="1">MLGCFLCAIALAAQLISAEPSDVCDVCHCSYSHIDNCDTSIAEFPINIPTSTTYLDLDFTAITSIPAGRLTGCALLETIEMLSCEQVTEIEPFAFDGLVALSKISLASAKITSIPPGLFRQCTSLSDINIGGPMTTLPAGLFKGLINLPASNFAIGSGNFTFGGNTLAPPSTYGSASSFLPCDPACDTCFSNGSTSCCPGNCLYCSNSIACTTCYDGFELTGAGACALPGQDSSSSSTAIIAGAAGGCAALLLLLVVLVLVARRQRRAKRLEAPYASAGSITYMNPLELAPQKERPSEQYASIDNHDDPHRTYEEISTRAPLSYDDVKSSAQPQSAQPLEGTYAETDPLTSSFFRTTVDKSHTNYANVTGILSADHVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR17</accession>
    <name>A0A0D2VR17_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cyclin M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_004088</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR17"/>
    <dbReference type="STRING" id="595528.A0A0D2VR17"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VR17"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR17"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000001">
        <property type="entry name" value="Putative metal transporter CNNM3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254422" evidence="15">
        <location>
            <begin position="51"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="17">
        <location>
            <begin position="241"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="439"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE93277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="852" mass="92152" checksum="1A5538B73CAB1326" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR71</accession>
    <name>A0A0D2VR71_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR71"/>
    <dbReference type="InParanoid" id="A0A0D2VR71"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR71"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="67067" checksum="57A3F7C37FAF44BB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRT5</accession>
    <name>A0A0D2VRT5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348197.1">
        <property type="nucleotide sequence ID" value="XM_004348147.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRT5"/>
    <dbReference type="STRING" id="595528.A0A0D2VRT5"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRT5"/>
    <dbReference type="OMA" id="AWTIVFK"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRT5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03564">
        <property type="entry name" value="ANTH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="589" mass="63892" checksum="35176453637C47EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRZ0</accession>
    <name>A0A0D2VRZ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348320.2">
        <property type="nucleotide sequence ID" value="XM_004348270.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRZ0"/>
    <dbReference type="STRING" id="595528.A0A0D2VRZ0"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRZ0"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254451" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="136" mass="14446" checksum="D589A5E157A3F8D2" modified="2015-04-29" version="1" fragment="single">VSSFVAASLVAAAAAAAAGESEKLQIGIKKRVENCERKAASRDKVSVHYTGMLTDNSVFDSSVTRGTPFEFTLGAGQVIKGWDQGIVGMCVGEKRRLTIPSHLGYGDRGSPPKIPPKATLIFDVELLEIKNAGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS27</accession>
    <name>A0A0D2VS27_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS27"/>
    <dbReference type="STRING" id="595528.A0A0D2VS27"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS27"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253837" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="824"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1113" mass="117733" checksum="BDA34EAC795B291F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSW1</accession>
    <name>A0A0D2VSW1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347676.1">
        <property type="nucleotide sequence ID" value="XM_004347626.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSW1"/>
    <dbReference type="FunCoup" id="A0A0D2VSW1">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VSW1"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSW1"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSW1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE94257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="139" mass="15581" checksum="2298E654B6835C57" modified="2015-04-29" version="1">MADYEDGGFEGDDGRDDAGEMDNDYGRDDELDNEMLEDAATFEIVDQDGLDAGDGVASGETKKRVTSPFMTKYERARVLGTRALQISMNAPIMVQRDGETDPLQIAMKELREKKIPIIIRRFLPDGSYEDWGVDQLEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTB0</accession>
    <name>A0A0D2VTB0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTB0"/>
    <dbReference type="FunCoup" id="A0A0D2VTB0">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VTB0"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTB0"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTB0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="176" mass="19911" checksum="14ECA80AD583E422" modified="2015-04-29" version="1">MEFDAPVDDVDVEIIPSAIRKRPHMNGVFYEGMRANACSIVGLVRSRFEREHNDLILRTGSSTDNAKFNYAWCLVKSRFRGDNRRGIEMFQDLLASGDRDRECLFFIALGYYRLGEYPNARVYVKRLLQIEPRNRQALQLDAAIDKLVSKDTLIGAAVVGGLSVIVGLGIMLLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTE6</accession>
    <name>A0A0D2VTE6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346835.2">
        <property type="nucleotide sequence ID" value="XM_004346785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTE6"/>
    <dbReference type="STRING" id="595528.A0A0D2VTE6"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTE6"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE94517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="244" mass="26455" checksum="AE6676ED53788C63" modified="2015-04-29" version="1">METVTQSLVTLLGEHCFDELVVKQNIANFDCLSHLLAKMLGYVIILGAVFVKIPQILKIVKAGNAEGISMISNVLELAGYITTFGYNAVLNYPFSTWGEYLFLTIQSFVLLLLLVHFSKAYVLGGLAILFEVALAYSIFSGLVSGDHLKFMLLATIPVFAVSKIPQILTNFRNGHTGQLSAVTLSMNLGGSLGRVFTTLKQVSDPIVLASSFFNSVLVLQLALYWGKKPAAAAAAKSTETKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVF1</accession>
    <name>A0A0D2VVF1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345496.2">
        <property type="nucleotide sequence ID" value="XM_004345446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VVF1"/>
    <dbReference type="STRING" id="595528.A0A0D2VVF1"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VVF1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VVF1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53310" checksum="A6DB4E7BC5C38FD1" modified="2015-04-29" version="1">MLFYESMTESQRELYDCFKNEKDSALSVHDFEFGEVEAEVLAEGLKVNKALTWLYLYENQLGDIGAQAIAEALKVNTTLIKLNLPENQIGEAGAQAIAEALKVNTTLTKLNLSWNQVGDDAAKAFAEALKVNKTLTRLKLHQVQIGDTGAQAIAEALKVNTTLTKLNLSWNQIGGAGAVAIADALKLNKTVTTIYLSGNQIGDAGARAIAEVLKVNTTLTELGLSENQIGDAGAQAIAEAIKVNKILTNLELGWNQIGDAGAQAIAEAIELGTTLTRLNIWYNCIGSAVAQLITEAKKLNYADVYADSQFNPLVLSLLPRLASAEDTQTVFCLLTSGLELENQRASLPALPAEIAELIMDEAHYWQGVQHIKRSQFDDDTPDDILQVTVPQGVNGNSIRVKSIQVLRDSRTLDGSIDDRGFDLIVRDEQGAVQHECSAKPTVVDLTLELATIWPASHPVIRQMREGWQVQVRPSKSPKDALFESLYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX56</accession>
    <name>A0A0D2VX56_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX56"/>
    <dbReference type="InParanoid" id="A0A0D2VX56"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="248" mass="28911" checksum="030FBBEA52B48C1B" modified="2015-04-29" version="1">MSDNDQDRLETATALMINLKHQSRREWRSRCSLLVREVGPASEAGWHLCEAGEDSDVGQEQDLDFAGLYFDLYKAAERGMLQQQVRKTLQDWQHVVDGVELNAFLMNVFFGFQWQAAKTAFERNVGTNGYPATWESFNTLSTITAQIQVYWLVFAYPALQYANCCFQELARFQYDFIVHVAERDQKTFWQFAPQLVFDFKLRNPKIAPLGPVDSFNSERALEKHDQYTLELEKLKEDSVLQLLTTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W214</accession>
    <name>A0A0D2W214_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346414">
        <property type="protein sequence ID" value="KJE98397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W214"/>
    <dbReference type="InParanoid" id="A0A0D2W214"/>
    <dbReference type="OrthoDB" id="2423641at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W214"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE98397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="959" mass="105436" checksum="6E0C400F399ECC05" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH69</accession>
    <name>A0A0D2WH69_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH69"/>
    <dbReference type="FunCoup" id="A0A0D2WH69">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WH69"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH69"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH69"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012316931" evidence="3">
        <location>
            <begin position="16"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="432" mass="49040" checksum="F4C3F83DD5C1E00E" modified="2015-04-29" version="1">MWLNWLSFAWNVVNSLKCRGLLRSQFVEEKMSKKILSQAHRQLAELEHEELGVNDPLTAKRRLPKQPEAAAASAKGKAAAQADDDSDAEDDTADPELYQDEASEEMFEQTVEVDEADEQAMEAFMSRDAPARRTLGDIIREKMKEKETEIASRMSDVSHLPEQSEVNPKVVQVYTAVGQLLARYRSGKVPKAFKIIPSLNNWEEILFMTNPDGWSAAAVFVATRIFASNLNAKMAQRFFNLVLLPRVRDDIAEFKRLNFHLYMALKKSLFKPAAFFKGILLPLCQAGNCTLREAIIISSVMTKVSIPPLHSAAAMLRIADMPYSGANSIFLRVLLDKKYALPYQVVDSCVFHFIRFQNDPRDLPVLWHQALLTFVQRYKSDLVVEQKEALMNLLKAKPHPLITPEIRREIMHSTSRDVEVSPMDAMMPIDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH92</accession>
    <name>A0A0D2WH92_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011269988.1">
        <property type="nucleotide sequence ID" value="XM_011271686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH92"/>
    <dbReference type="STRING" id="595528.A0A0D2WH92"/>
    <dbReference type="eggNOG" id="KOG3606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WH92"/>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WH92"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="72772" checksum="D2EB7D0A0DA2E66B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI00</accession>
    <name>A0A0D2WI00_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365729.1">
        <property type="nucleotide sequence ID" value="XM_004365672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI00"/>
    <dbReference type="FunCoup" id="A0A0D2WI00">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WI00"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI00"/>
    <dbReference type="OMA" id="REENWEN"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI00"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="171" mass="18492" checksum="2F3F8100F1B775DE" modified="2015-04-29" version="1">MSSNRSNKNNSNTTTSSSISSSSSSSITSSNGNSKAVAAVPEEIAEQVDAFTAAVDNLEAMLNPLLKAPAADLRAKLADKPLELARLELALAFTANSMFWMYLNAQGTAPEDHPVKNELARIKHYMTKVKTATEKTIAHPRLDKAVTDRIIAHNISSPALSEKIKRKSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIL4</accession>
    <name>A0A0D2WIL4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_001123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365994.2">
        <property type="nucleotide sequence ID" value="XM_004365937.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIL4"/>
    <dbReference type="FunCoup" id="A0A0D2WIL4">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIL4"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIL4"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="404" mass="45096" checksum="70990285542E3532" modified="2015-04-29" version="1">MLLSAGIALNRGNRRAWTTLARKVHSKGSISPIAPGAAAAAAAAALQQQQQQQGNRAPGILFDIDGVLIRGNTVLNEAKEAFQMLSKRHLLKNIPYMFVTNGGGTTEAHKAHQLSKWLHVPVSEKQVVLSHTPLRMYEQYFNKTVLLIGQGPLKEIAASYGFQKTLDLDDMRKAFPLMDIVNMKVRKQLKSHPPTPIPVPPVEAIFVMHDPLEWESCLQVLIDLLISKDGVPGTLDSKQHIPIIFSNADFLWMAEHPQPRFGQGAFRLCLEALYKELTGRDLLYTQLGKPFGVTYDYAEKLLNEQAQKLGYDGLSYFYMVGDNPRSDVRGANSRQNGRSVLVRTGVFSPHLDNDPSDPAHFVVPHVRDAVQLVMRHFDDGLHHHGGSDELHAHFVQKSRTRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIM2</accession>
    <name>A0A0D2WIM2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BLOC-2 complex member HPS6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366008.1">
        <property type="nucleotide sequence ID" value="XM_004365951.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIM2"/>
    <dbReference type="OrthoDB" id="8581967at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031084">
        <property type="term" value="C:BLOC-2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017218">
        <property type="entry name" value="BLOC-2_complex_Hps6_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046822">
        <property type="entry name" value="HPS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14696:SF2">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14696">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20468">
        <property type="entry name" value="HPS6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-2 complex member HPS6 C-terminal" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1322" mass="140141" checksum="469E1FC3E9F63294" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIZ2</accession>
    <name>A0A0D2WIZ2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_000662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365533.1">
        <property type="nucleotide sequence ID" value="XM_004365476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIZ2"/>
    <dbReference type="FunCoup" id="A0A0D2WIZ2">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WIZ2"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WIZ2"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WIZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="127" mass="13774" checksum="EB5A111AA56D6EF7" modified="2015-04-29" version="1">MTEGVNPKAYPLADPQLTTTILELVQQAANYKQLKKGANEATKTLNRGISEFIVMAADAEPLEILLHLPLLCEDKNVPYVFVPSKLGLGRACGVSRPVISASVTSNESSQLRGQIQQLKTSIEKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJH1</accession>
    <name>A0A0D2WJH1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364401.1">
        <property type="nucleotide sequence ID" value="XM_004364344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJH1"/>
    <dbReference type="InParanoid" id="A0A0D2WJH1"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJH1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="246" mass="27441" checksum="D50F36957F25AF61" modified="2015-04-29" version="1">MSHIMSGWVQREESGLVKSFKRRWCVVQDTAVCVYKDDKDVLLQFEHQQPPLDVLFAEDITSVQPLVSQQGQQFGFEIGTSHGATLALRCSEDEHNEWMAAIRLLTRREKPIAVAGAPVMDFVTIECFTLRGIRVDGSIEPHILAVLSDFDGRPIDPAKRAKKIEDVRGWFCNRFVALPDVLNLMTQHEWQLQSCAAAESQTPTDKAVVQCHRLVFHRPRLPSPAPAPAPATSPTGSASSFPSVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJS8</accession>
    <name>A0A0D2WJS8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGEF domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364572.2">
        <property type="nucleotide sequence ID" value="XM_004364515.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJS8"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJS8"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJS8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040655">
        <property type="entry name" value="TIAM1_CC-Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18385">
        <property type="entry name" value="Tiam_CC_Ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="252"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="730"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE90385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1436" mass="153500" checksum="17A03C4ABC75DCC7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK13</accession>
    <name>A0A0D2WK13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK13"/>
    <dbReference type="InParanoid" id="A0A0D2WK13"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269979" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="509"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="566"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="633"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1717" mass="180143" checksum="74A29620538CADA7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK22</accession>
    <name>A0A0D2WK22_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Insulin-induced 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364693.1">
        <property type="nucleotide sequence ID" value="XM_004364636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK22"/>
    <dbReference type="STRING" id="595528.A0A0D2WK22"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK22"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK22"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="381" mass="40162" checksum="62C481B7A206E24C" modified="2015-04-29" version="1">MVVHQPTSSSSSSSSSSSSSSSPTSPSLNHAIDDQQPHATAALRQRSRGGTASASVAEHQQAPRPILARETSDDNDHNHDHDNDHDHDRSAVASAATAASDKPPVAGGAGAGAQAAPQLSRPSSEAAMMALLLKAPPTAQLPMRMGTLFLCGVFFSILFNVLQRQHHVTQFPGASSSSGGGSTSAAAAAAAAAFSSPVSQAATDQLLAPSLQVLGSWSAAIMSSAWWVPVVCGLAAILVGVAFPYVDYLLRAPHVFKRDWSSVMRCVGVCIGINYASAKLPFSTNVQLSLMLALMAIALWWMFDRTLRGFLMGLVVALGSTSAIQLLVFFGAFNFTQPDFFWVRSWIPCIFFATGVTFGCIGRQLAHDAKLDYLLQAKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK35</accession>
    <name>A0A0D2WK35_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK35"/>
    <dbReference type="STRING" id="595528.A0A0D2WK35"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK35"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK35"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255020" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="810"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1100" mass="117157" checksum="33146433E232A0B4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK43</accession>
    <name>A0A0D2WK43_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349844.1">
        <property type="nucleotide sequence ID" value="XM_004349794.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK43"/>
    <dbReference type="InParanoid" id="A0A0D2WK43"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="686" mass="72426" checksum="702060A212A818A4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKA2</accession>
    <name>A0A0D2WKA2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_001913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364781.1">
        <property type="nucleotide sequence ID" value="XM_004364724.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKA2"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKA2"/>
    <dbReference type="OMA" id="WEANTIY"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKA2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="375"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="852"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="910"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="770"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE90630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146192" checksum="ADE57F093F89CB98" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLC2</accession>
    <name>A0A0D2WLC2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_002494</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349244.1">
        <property type="nucleotide sequence ID" value="XM_004349194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLC2"/>
    <dbReference type="STRING" id="595528.A0A0D2WLC2"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLC2"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLC2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270018" evidence="14">
        <location>
            <begin position="28"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="538"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE91350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="854" mass="89834" checksum="89BD7BC5DC9299AB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLI6</accession>
    <name>A0A0D2WLI6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364860.1">
        <property type="nucleotide sequence ID" value="XM_004364803.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLI6"/>
    <dbReference type="InParanoid" id="A0A0D2WLI6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19123" checksum="91C8BFC2874B634B" modified="2015-04-29" version="1">MAPPALESSCNTLVAPASPAASNTRAAKTNPAAGSTALFGQTRVTSYPAANAPSDGGFATLLSAEQRAADQLAKVFVAAPLDLVNHHSPTWTAMLTVNRRFVIQPPSSAAAALGAKQTLVVLLDLAEHHLCTEVSLVVLRNAESADANAETDALVRGLVYLGFALAAPGSANQLGNSSYHTLTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNI9</accession>
    <name>A0A0D2WNI9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363334.2">
        <property type="nucleotide sequence ID" value="XM_004363277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNI9"/>
    <dbReference type="InParanoid" id="A0A0D2WNI9"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNI9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254618" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45806" checksum="303D9049B5B68EDC" modified="2015-04-29" version="1">MRASRLALTGAFAIVALLGLFWLRQPQPPSSSSQHGDDGHSAAADSTRDGDLAAELASWRVHWPTTVHSDPLSVRAAVGRPAAWTYLDSQCSSPAICESLLENAPCPDGPTPALTPSDPRFGNHPELNLPRCSYRRIASCFPRDLQTCFARRLLSNHWLVIVGDSVTRNTLMEFFMRHLPQSEQVKLQLSSERNLHVPSSQYQNEDYLLFGRFLVTFRFIGGAGGNQTRDNLVQGVSLSAAARTALLSRLSALLQARNETIPDAELDVLYRKPDIVVINSGLWDSRSSSPSYRPNYYGSMHMWRRVLQEQLGLDAKQLYWRSSTPVSPELHVTDQQRKNMTNERIAELNWIAHDVLVRQAHWHSIDAFTAVGGFVPPVDAISYDGYHPTTLASCALNDMVFGAICDKEASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPE5</accession>
    <name>A0A0D2WPE5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPE5"/>
    <dbReference type="InParanoid" id="A0A0D2WPE5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="445" mass="47270" checksum="F7711BE8653D7DE5" modified="2015-04-29" version="1">MRSTRGLAQGQQAQAQAQGQQQPQAQGQQQAQTAGRPLPSTQPTVDLAALAAALPQIGQLWQNNLTDAGDVHGDAQARGQRAYANQQAALRLQASLQQRAQSQSQSQSQSQSQSQSQSQSQSQAQAQAHGNAQLGLPNDLGGFVSLLTEAALLPKAELMNVARANNANAARASSSPQFGQSAAPPAATARTSAASGNTGAAGGCASGVCPAPTQPGAGLAALLANPAVAQFANDLVVRKLHERAAAATSAGAGAGGGQTGDLPPLDTFLQLLATEPQRLWERIQWRASVEEAARESPLSCERVSDAINEFCIPVAINVTREGFPVNHIPALRFAESIYQTNWRFEFGFASCFIVDDTGAIPLGVASNSQVTKTPRAVYEREYLLFIVEALERFKSLQAIRRGNLGELRTFAASLMQEFSRRASQMAQQRQQFEGFAQRHPQLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPN5</accession>
    <name>A0A0D2WPN5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363296.1">
        <property type="nucleotide sequence ID" value="XM_004363239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPN5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPN5"/>
    <dbReference type="InParanoid" id="A0A0D2WPN5"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="119651" checksum="438093981C78A6BC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPP0</accession>
    <name>A0A0D2WPP0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348048.1">
        <property type="nucleotide sequence ID" value="XM_004347998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPP0"/>
    <dbReference type="STRING" id="595528.A0A0D2WPP0"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPP0"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPP0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="315" mass="34220" checksum="37AC825CA4C1DED5" modified="2015-04-29" version="1">MAAWNPAGTLLATVWQPELEGQGSEAWHCTAVLEEAHSRTVRAVAWSPDGRSIASGSFDFTVCIWDKSSGEFDCTATLEGHESEVKGVAFAPAGNVLASCSRDKSVWIWDVEEDGEFECAGVLHEHTQDVKFVRWHPTEPILASASYDNTIKLYREDDGDWVCYETLNGHESTVWALAFNADGSFMVSVSDDRSLKIWKRLNPGNKEGVAVLTSQAPKWKCVATVPALHERTILSVDWSPVTGLIATGGADNVIRILKFNESDVDQNGQAAVSVVCSVDAAHTQDVNSVAWNPVRGSLLASTSDDGSVHLWNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPU3</accession>
    <name>A0A0D2WPU3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363415.1">
        <property type="nucleotide sequence ID" value="XM_004363358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPU3"/>
    <dbReference type="FunCoup" id="A0A0D2WPU3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPU3"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPU3"/>
    <dbReference type="OMA" id="AWRPAHE"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPU3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="32721" checksum="7C81AE603BD258C3" modified="2015-04-29" version="1">MVKVFVTGATGLIGGSVARQLRRAGHVVYGLVRTEEKARVLAQDDIIPVIGQLAGLAAHSALIATCAAVIHAAFDGESFLETDALVIHTVLNAPFASGQKPLFVYTSGCLMIPNRDEHSGYVDDFTTPLPHSSQAYRLKNEQVVTSATTVHGVVLRPGFVFGKGAAHFERWFAQFHKNVPEVVIPAAERQYSYIHADDLAEAYQRVVENPKIASGSVYTIGDDSRITHIEFARVFAKAAGYQGKLVASDANLWPPMDRSCFVDWRRFGLEFNWHPRHLPITDEADIYYAGWKARQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQD8</accession>
    <name>A0A0D2WQD8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_004595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347342.1">
        <property type="nucleotide sequence ID" value="XM_004347292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQD8"/>
    <dbReference type="FunCoup" id="A0A0D2WQD8">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQD8"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQD8"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQD8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="200"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="467" mass="49478" checksum="C042E83A45EE8A4C" modified="2015-04-29" version="1">MQSLTRRSARLLASSATAIHAAPATHNTPSKSESPLVQSTRAESRVASSPRSKRTHSQATEPSAAAAAAVPSPSHSIAAEAQSTEQAASSSSSAPSSRSKRARIQEPAEQGSAPTPTTAAAKPTVARRARTNKSTSNDSSSNSTIASVKVEAADQAIPAAGSSPSGIGSLPLSTLSTTVSRLVGYHVSTAGGVQNAPVNAALVGATAFAMDTRSKRKWDSPPYTAATIQAFRKACCEHGYQPHQILPHGSYLINAGSPVPEILAKSRAALIEEVQRCEQLGLSQYNFHPGSTVGLCTTEKCIETIAESIDLAVGASKAVTVVVESMTGSGNVIGGKFEHLRDIIAHVKDKTRIGVCLDTCHMFAAGFDLRTRAEYDKVMNDFDRIVGFQYLRGLHLNDSKGELGCNRDRHENIGKGKLGLSAFELIMNDERFRNIPMILETPVSAEVESDGYKKEIELLQSMVRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQW0</accession>
    <name>A0A0D2WQW0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347571.1">
        <property type="nucleotide sequence ID" value="XM_004347521.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQW0"/>
    <dbReference type="InParanoid" id="A0A0D2WQW0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26141" checksum="E171D31BD01124CF" modified="2015-04-29" version="1">MSETGTTTTTPTTTAITTTTTTTITTTASNASEWSPQAVGIAAGVAFTVGFVGRLVVVTRKQSRQLKEQMRTAHEQVAQTRLRPAQAYQTAARTPSSRTSHVPLRDMLSLSSHPTSPSAFAAKALIFGTVLCGTVAGISVFAVAKSMGVSSMEEFAHRMRVIVPEYSASISSSIRGLGLASTRNQPSDDANAAKPAASHEATPTTTAKVALPPSSIPQEDETFEQRMRRIFGRRAAEPASSPSSPSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSF2</accession>
    <name>A0A0D2WSF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346705.1">
        <property type="nucleotide sequence ID" value="XM_004346655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSF2"/>
    <dbReference type="eggNOG" id="ENOG502TD23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSF2"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="OrthoDB" id="2128165at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050638">
        <property type="entry name" value="AA-Vitamin_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322:SF2">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="174"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="392" mass="43035" checksum="A1D4DA2DB99F4F04" modified="2015-04-29" version="1">MRVIEAVAFVALGAIWGSSFLFIKWSATYFPPLTLVGMRLLLAAIIMFAFNGILAVVRPSHRDILKSHFRRDFILKALMMGFLNNTIPFTLVAWAETKSAVNVGITSVLDSAIPLFGQLFGHFLLPNERITLKRGIGLVVGFAGVIVVCLERMIDSGDDDSNSDTCNACVYGYYAMIIGATASYAIASVWGKRTLHEFNPVVTATAQITSGMLINVILALLWEFNWPVDNFAGQTHFSFLDDADYKAWIGIVYLGVVSTCIAYSLYFYLLATIGSVRQTMVGFLLPIFGVFEGALFNSDWAGVSWVYKVLEVVGTLLIGAGIYFVNMSDKKKPQPDGESDDEKVALINETSSDYKSYANGGVTRFLNNQVINGAPTSPHDPRTSMHNVQSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTL9</accession>
    <name>A0A0D2WTL9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345022.1">
        <property type="nucleotide sequence ID" value="XM_004344972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTL9"/>
    <dbReference type="STRING" id="595528.A0A0D2WTL9"/>
    <dbReference type="eggNOG" id="ENOG502QSQA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTL9"/>
    <dbReference type="OMA" id="CEAQMES"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02087">
        <property type="entry name" value="HAUSAUGMINL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32423" checksum="DAD124292636B4D7" modified="2015-04-29" version="1">MSQQQQQQQQEHGLRADASAKLEKARVWLASVFHPAPVPQFEVTEDTVAAIWKLAAAAQERDANAVALAADLALKSQEYQAEATRVQELLALHGLDKSRLSDQTHANVRSLARLASLLHVNDTSLASLYCALSDLSASTFDEWDGELQRQRRAQTMHEQVTSSLSRLSELRRTLAELDQAETANVEIVERRQQERTFYNNKAAEYQASIAKLQQQHPLASEPSIRHAAIMAESEAVKQIIDELTAIRTTLDTFQKLPPDFTMAKLKIEEARRELSRLEQAVTQGFSAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTV1</accession>
    <name>A0A0D2WTV1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346304.1">
        <property type="nucleotide sequence ID" value="XM_004346254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTV1"/>
    <dbReference type="STRING" id="595528.A0A0D2WTV1"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTV1"/>
    <dbReference type="OMA" id="HNMNRQF"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTV1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="339" mass="38153" checksum="49DD04EDC11A030A" modified="2015-04-29" version="1">MTGGSSRANSWRNAVLVTGATGFVGFHSALALKRRGDFVVGLDGYLPDSDATLRQARKHELTNKEVPVIKGDVCDKELLRTLFKAAVITNVLHLASQAQSNEQQQQQQQQQQQQQQQPEELRHDVRCFVTLLQVVREFQSASRPISVVYVSDSTGTAEEELPSLSTVSRHDVAQVYHQFYGLFLTGMRFSNVYGPYGQPNMPYYSFTERILADQPVVVQYNANGKEPQYDFAYVSDVVDDILRCIDYEAEFEVFNLGSGKRESLRSLIAHLERGLGRHARVVREQATEDVLTPDSSEDIQRTRKTLGYSPRVDLSAGIAHFLNWHKQFRSQQGGPAPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU69</accession>
    <name>A0A0D2WU69_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU69"/>
    <dbReference type="FunCoup" id="A0A0D2WU69">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WU69"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU69"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU69"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="332"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="953" mass="106476" checksum="6303932D27DC5CE8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUQ3</accession>
    <name>A0A0D2WUQ3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">phytanoyl-CoA dioxygenase</fullName>
            <ecNumber evidence="10">1.14.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phytanic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phytanoyl-CoA alpha-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="10"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUQ3"/>
    <dbReference type="STRING" id="595528.A0A0D2WUQ3"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUQ3"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000012">
        <property type="entry name" value="Phytanoyl-CoA dioxygenase, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="394" mass="43797" checksum="892BC4860F5BB9B0" modified="2015-04-29" version="1">MPRQSEHLPLIRNIATLAGLDARRKKAEVVGDFLLYFQSFSPPSMSFSSSSSSSSAAARLAVTLGHLAPQHASFGTADCAAAALTTQQPAKGNKLKYTHDIASTILTREQRRFYEDNGFLLVKKLIDPSVLNEIKDHFVALCNGEKERFSTTTVMRDVTLAKQKGLKGERAVTKVQDFQDDPDLFRYCQLPEVLKYVQCFTGPNIRTIHTMLINKPPDVGPTGRHPLHQDLVYFPMEPANRICCSWTAMEPVTRANGCLVVLPGTHKGELLEHGYPEWEGGVNKAYHGIKSAQQEKGDLVYLEMEPGDTVFFHPILIHGSGANKTSGYRKAISGHYASAGECSYIDVTGGPREELAREIEEMAKAKLRTDEHIKIQDIWRMKSRLVQGEDVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV99</accession>
    <name>A0A0D2WV99_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV99"/>
    <dbReference type="InParanoid" id="A0A0D2WV99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="152" mass="16338" checksum="466BBAA379283406" modified="2015-04-29" version="1">MASGCYEWRQVAAPSGLANVTKRQKTISALCLFFFFAGTFWSDSCSGLARLLSRWGGLSPLVLWPSAHVVSQWSWQASRPSVKCGRPTAFQNPKKTTSPRPLSACCRVDRSGLSLLLAACDGCVPPAIRASLALAGSRLRLSSPRSFALGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC9</accession>
    <name>A0A0D2WVC9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343800.1">
        <property type="nucleotide sequence ID" value="XM_004343750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVC9"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVC9"/>
    <dbReference type="OMA" id="TENDAMF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVC9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31173" checksum="45E20637347F8751" modified="2015-04-29" version="1">MSARQRELYDKVKNAREWFSLHDNQIGEDGARAIAETLKVNTTLTKINLTENQIGDAGARAIAETLRVNTTVTDLGLWKNQIGDAGAHALSAALKVNKTLIKIDLNGNQIGDAGAQAIAETLKVNTTLANLGLHNNKLGDAGATAIAEMLKVNKMLTSLSLDNNQIGNAGALAIAEALKVNKTLTWLNLSENQIGDAGAQAIAEALKVNTTLPCLVLQQNQIGDAGAHAIAEALKVNNTGLIVLFLNENEIGNAGAQAIAEALKVNTTLIVLLLGDNQIGDAGAQAIAEAFKSGAELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVU7</accession>
    <name>A0A0D2WVU7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344389.2">
        <property type="nucleotide sequence ID" value="XM_004344339.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVU7"/>
    <dbReference type="InParanoid" id="A0A0D2WVU7"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1459"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2627" mass="288854" checksum="43DAE03455320D61" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWH9</accession>
    <name>A0A0D2WWH9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270790.1">
        <property type="nucleotide sequence ID" value="XM_011272488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWH9"/>
    <dbReference type="STRING" id="595528.A0A0D2WWH9"/>
    <dbReference type="eggNOG" id="KOG0456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWH9"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="493"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="1031"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1083" mass="112866" checksum="A6D55650AC464102" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX13</accession>
    <name>A0A0D2WX13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343561.2">
        <property type="nucleotide sequence ID" value="XM_004343511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX13"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX13"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="352" mass="38940" checksum="ECBC14F766804BC4" modified="2015-04-29" version="1">MQFTRSMRKRQRELYDQVKNARKHLAVDRNQISNTEVQIFAEALKVNTTATSLGLAHNQIDDSAAAMIAEALKVNTALAYIDLGWNQIGDAGAQAIAETLKVNKTLTRLGLYQNQISDAGALAIAEALKVNTTLAYVDLRLNCIGNAGLQALGEARQVSHTLLDLNIDQQMHPRMFSLLSRRLATAEDLQNVFHLLSSGLALEDQSAALPALPAEIAELIMDNAHYWQGVQHTKRLHFYDDSPAYILNVTLPQGVNGNSIRVKAINVFRDSRPLYGSNGSSGFDLIVRDEQGAVRYECSVKPTLVDSNLDLVTILPANHPVIRRMRAGWQVQVRASKSSRDVLFESLYVGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXA5</accession>
    <name>A0A0D2WXA5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007877</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342962.1">
        <property type="nucleotide sequence ID" value="XM_004342912.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXA5"/>
    <dbReference type="FunCoup" id="A0A0D2WXA5">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXA5"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXA5"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXA5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="70"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="254"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="717" mass="81131" checksum="6EB81456CDFC9417" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXH5</accession>
    <name>A0A0D2WXH5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXH5"/>
    <dbReference type="InParanoid" id="A0A0D2WXH5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111103" checksum="6C4D7EE51D17AEE3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXL7</accession>
    <name>A0A0D2WXL7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343221.2">
        <property type="nucleotide sequence ID" value="XM_004343171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXL7"/>
    <dbReference type="FunCoup" id="A0A0D2WXL7">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WXL7"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXL7"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXL7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="338"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="501" mass="53971" checksum="84B5DAE3B5813E39" modified="2015-04-29" version="1">MASSSTLPPAKWADDSEDGPTPDPVPAAAAAAAAAAAAPAPASTPAATAAADSLAEKLEGVAITPNKAAGASTSSGYNFAAKDGPSQIDWSGEVEVQQNDKDSPLYSAKSFEELQLRPELLQGVYAMKFNKPSKIQETALPMMLANPPKNLIAQSQAGTGKTAAFVLGMLSRIDETKPYPQAICLSPTRELTRQTAEVIQAMAKFTKITTLLAVKDGVPKGARITNHLVVGTPGTVQDLISKRAFDPSHVVVFVLDEADQMLDQQGMVDISFRVHRTLKPTTQCLFFSATFKPEIRDMALRVAGGSANTIKLQRQELALDRIKHVCIMCDSEAKKFEALSDIYGLVNVGQAIIFCQTVAKVDSLAKQMTSAGHTVSVIHGQSMESADRDKVIDDFRKGATKVLIATNLLARGIDVLQVNVVINYELPMHFGDKANEPDCETYMHRIGRTGRFGRKGVAINFVHDARSRQAMDQIEKFMVKAKVERIQASDLEAIEASLTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY60</accession>
    <name>A0A0D2WY60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_008304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346388">
        <property type="protein sequence ID" value="KJE98325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004341904.1">
        <property type="nucleotide sequence ID" value="XM_004341856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY60"/>
    <dbReference type="InParanoid" id="A0A0D2WY60"/>
    <dbReference type="OrthoDB" id="1880105at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026686">
        <property type="entry name" value="UPF0708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14937">
        <property type="entry name" value="DUF4500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE98325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="62" mass="6980" checksum="68C304E9B986AF86" modified="2015-04-29" version="1">MSDKEPPKRPPVTSTTLFRVLNPELFLRPNKYVMAFGLGALTLSLGFVWWQSEGQLGPNSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYG6</accession>
    <name>A0A0D2WYG6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_010174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYG6"/>
    <dbReference type="InParanoid" id="A0A0D2WYG6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="398" mass="43206" checksum="47726DCEAC47A5C6" modified="2015-04-29" version="1">MLEFVCDAFRSSLVPPADSARWPSEALAVALNASDTLQSIDNLLSQLRFNDYELPATILTALLPFVDWITPFVICIFKNLMHVARSRAATELVQSQDSGSSASNTTPFLSFLFQSDAAQLLRETLVYASLLKHQASISTSKVIQQHNNVQQQQQQHSQPQYEQQQQQIYDSAASLGALNHGVARESSATIKKLFNILSEISFKAARDDISNLISALEVLQKPEYEQTRLMRSLQLSSTSRGVLGQLAHVVHGPALRVLARDAPDTAITAATPVACPAFLFGKATKSLVPGIFNSTAEVVPGREVDGVNSPHGGRGVASPPAEVPGSVLLSDVMEGDAFDDDTTDARFTVRSRRSVSLAALNSVQKTTGSTVTEPPHARRDVLKQTFVSGTVDFRECMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0D4</accession>
    <name>A0A0D2X0D4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365311.1">
        <property type="nucleotide sequence ID" value="XM_004365254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0D4"/>
    <dbReference type="FunCoup" id="A0A0D2X0D4">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0D4"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0D4"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0D4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="174" mass="20423" checksum="5B8374D5B5ED7939" modified="2015-04-29" version="1">MRVTGALRQFEIIGRKLPTEKEPVTKLYRMKIFAPNDIVARSRFWYFLSKLRKFKKTSGEVVSCSEIHEKKPKTIKNFGVWARYDSRSYHHNMYKEFRDLTIAGAVTSCYRDMAARHRVRGRSLHIIKAAEIPAAKCRRVAVTQFHDNALKFPLPHRVLKSKAKFLAKRPHTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0I0</accession>
    <name>A0A0D2X0I0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ganglioside-induced differentiation-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0I0"/>
    <dbReference type="STRING" id="595528.A0A0D2X0I0"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0I0"/>
    <dbReference type="OrthoDB" id="365077at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0I0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="52"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="338"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="515" mass="58551" checksum="6F308044295161D8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0N9</accession>
    <name>A0A0D2X0N9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endopeptidase ATP-binding subunit clpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365738.2">
        <property type="nucleotide sequence ID" value="XM_004365681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0N9"/>
    <dbReference type="FunCoup" id="A0A0D2X0N9">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0N9"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0N9"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0N9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="164"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="565"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="734"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="378"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="844" mass="92988" checksum="0FD0B4968780A130" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0R4</accession>
    <name>A0A0D2X0R4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365841.2">
        <property type="nucleotide sequence ID" value="XM_004365784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0R4"/>
    <dbReference type="STRING" id="595528.A0A0D2X0R4"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0R4"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0R4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="337" mass="37834" checksum="F44F03779F55EAC5" modified="2015-04-29" version="1">MRNGTSGESEPSVRELFDHPTTVFLAFVGVDCAAWLLLLCVFGWSILRHCRAVAPANAAYKTAIYFVICTPMIMATLSLACLFFPEAMVVSSMVQSTYEAVALWKFYVALRCLLGDVPHMHKVLGALPPKNYYSVLIFKLCCWHHGKFVMDESHFRTLRLCVLQICIVRPVVLLGSVILWSFGLYTYGNYSMSNGYLYITIINATSLLVTMWALLVIFFATRTILADFRIGLKFTAIKLVFLLAIVQSFVLSLYNNVFGLKGNIFTTHDQVESWLNWLLVIEMFLLSLLFAKAFPASEYEHVPEPGSLSLSAQDSVNGFTRGSERTPLIVRAPKGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0S0</accession>
    <name>A0A0D2X0S0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365864.1">
        <property type="nucleotide sequence ID" value="XM_004365807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0S0"/>
    <dbReference type="InParanoid" id="A0A0D2X0S0"/>
    <dbReference type="OMA" id="CAYSEDF"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0S0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266719" evidence="2">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="225" mass="23525" checksum="4FE7A89D813121B7" modified="2015-04-29" version="1">MTFSRFVLVPLCMMLAIAGTSATDAVLRMYGDAACTTSTSPPVAWWVVQPGSCQNSTEFSDYYSVTVDSSTQITYSFGCDNTCTTCTQSSIMTPGTCLEIGAGSGDYLTVYPVVAATIDVQVSNSCPGPAWATYTVTSAQCASIGPILGNSRITVVGNDTIAYSFGCDDVCGYCRLNGQTSEDTCTSEPPAFHVTYHVNSAAGITSSVAFVGLTAVLMSMFALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X178</accession>
    <name>A0A0D2X178_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X178"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X178"/>
    <dbReference type="PhylomeDB" id="A0A0D2X178"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="282" mass="31020" checksum="291C1896580EF3BB" modified="2015-04-29" version="1">MRIRLEKLERGRLPRHSKSNTLTWLKLNRNCIGEDGARAIADALKVNSTLRCFLLKQNQIGDAGGQAIAEALKVNTRLTDLFLEDHLIGDAGAQAITEAFKMNPKLVNVFVYDQINPLALSLLPRLATADDLQTVFCLLTSGPALEDQSTFLPALPAEIADIIMDEAQYWQGVQHIKRCQFDDDSLEHILKVTLPQGVNGNSIRVKAIQALRDMGNGFNSNGSSGFDLIVRDEQGAVRYECAAEATIVDSTLVSARVGWQVQVQPSKSARDVVFESLVVKCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1A2</accession>
    <name>A0A0D2X1A2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_008546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270128.1">
        <property type="nucleotide sequence ID" value="XM_011271826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1A2"/>
    <dbReference type="InParanoid" id="A0A0D2X1A2"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1A2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55716" checksum="C7BE516F0A3C7E1F" modified="2015-04-29" version="1">MTVIACEWPYMTFPACNQTFAEFMGSTYTGYQVVFCLLFIPLFLVTLWQYLLAIQKQHWSFNPGQDVQVQILTLLVIGTATMVVRAADVYGWAGNISIYVNNLMYDIGSAAGVCCVFVIVWSWYSFLSKSTFKRTTSKLPRLFYRGSIIVVWITQIVCCTLQYNAGIYWQAVIVKYAITNAIMFSWLVFGFWYGLQIYRMLVIAEKKFGKLSESTAGSSHARPQAADVSGEEATEEEVAEEDDDDADVEAGTAQQPNPNNRASGGSLRLKTNPAVAGAAAAPTASKHKSSRTSRSTGGNNGEGIRSRRRARAIRKIFALLRIMIAVLVACVAVLIWSISSNASSQYDLKVDGKPLEVPTGSFSMVTPGLFDYVHFIAFCVLLHAYRVTGAQEKPVTQDTTEDTDRNSTLKSSQKRRKANRDSFDRSEYPSQYEKSVAQPEPAPATSSQSDLIVHSVAPSSPKQTPSSPKKQHAAVEAQSLESPMQGAEDLQDVVLEIPDEVRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1H9</accession>
    <name>A0A0D2X1H9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair helicase RAD25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348832.1">
        <property type="nucleotide sequence ID" value="XM_004348782.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1H9"/>
    <dbReference type="FunCoup" id="A0A0D2X1H9">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1H9"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1H9"/>
    <dbReference type="OMA" id="RICDIRT"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1H9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="598" mass="65340" checksum="A3F91C9069F4070F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X246</accession>
    <name>A0A0D2X246_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363818.1">
        <property type="nucleotide sequence ID" value="XM_004363761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X246"/>
    <dbReference type="STRING" id="595528.A0A0D2X246"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X246"/>
    <dbReference type="OMA" id="EKECANS"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X246"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="104"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="538" mass="57867" checksum="A6CF6424DC9BB037" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X248</accession>
    <name>A0A0D2X248_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X248"/>
    <dbReference type="InParanoid" id="A0A0D2X248"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="165" mass="18325" checksum="A2B2A806DFFFE1E3" modified="2015-04-29" version="1">MGEPSSVSSPCSSSSSSSSSLLQLWLLRRDSLPMLSRILVAFFLRPVGRPLTENGSLISTPLYDQAKNSVRWCPLRTLEVQVQRKPRLSTAGTKLPCLRRVPRKDFWLEGLPMKANSPVHEPSIALVQLRHRVTTKSYSSCIASVFGTDVLVRATKRTVHRTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2B5</accession>
    <name>A0A0D2X2B5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_003270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364109.1">
        <property type="nucleotide sequence ID" value="XM_004364052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2B5"/>
    <dbReference type="FunCoup" id="A0A0D2X2B5">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2B5"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2B5"/>
    <dbReference type="OMA" id="VYDYARP"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2B5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE92269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="187" mass="19468" checksum="84B4EC9E3129357C" modified="2015-04-29" version="1">MSSLFARLALPRASSLILASRPVAARALCSAASIAQARLPAAAAPAAARAASPFSSMMLRAPVTSAAHTQARTPVAFASTSAPAASHGKESSHWKFERVVAIGLLVAIPTAAVYPHIAVDMALALLLPIHGHFGLHQLITDYVHPKPAIFLANNALRILTLATAASLIYFNLSDVGITHAVKALWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2S7</accession>
    <name>A0A0D2X2S7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363650.2">
        <property type="nucleotide sequence ID" value="XM_004363593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2S7"/>
    <dbReference type="InParanoid" id="A0A0D2X2S7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2S7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="603" mass="64953" checksum="5F1709FF4D7A2BEB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X427</accession>
    <name>A0A0D2X427_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucosylceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346460.2">
        <property type="nucleotide sequence ID" value="XM_004346410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X427"/>
    <dbReference type="STRING" id="595528.A0A0D2X427"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X427"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X427"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266800" evidence="4">
        <location>
            <begin position="36"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="122"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="241"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="513"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="62219" checksum="9A6D21F483801296" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H9</accession>
    <name>A0A0D2X4H9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H9"/>
    <dbReference type="STRING" id="595528.A0A0D2X4H9"/>
    <dbReference type="InParanoid" id="A0A0D2X4H9"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4H9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="45276" checksum="BF03F9FDEEC8C567" modified="2015-04-29" version="1">MEDSQPFEHIDDAGAQAIAEGLKGNPNVEKLFLGWNQIGDAGARAIAETLKVNMTVTVLDLYDNQIGEDGARAIAETLKVNTTLTKINLTKNQIGDAGARAIAETLRVNTTVTDLGLWKNQIGDAGAQALSAALKVNKTMTDLDLNGNQVGDAGAQAIAETLRVNTTVTRLSLYNNKLGDAGATAIAEMLQVNKMLTSLGLGRNQIGDAGANAIAESLKVNTSLRTLGEQFDSLDKIGNAGAQTMAEVLQMNTTLTHLSLGLIGDAEAQAIAEALKVNTALHSGKFFYRNPTGIRTGKIRIPRNLSFAPDFDRISTCLSDMVWRHRPRLHLLMLLPGLDGLPDNTLATRLATRLATRLGTLLDSSTRTAAVVDAGAVVDAGAVVDAAVVDAAGVDAAGFDAAGFDAAGFDAAVADAAVYYAAVVDPDIIVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4J0</accession>
    <name>A0A0D2X4J0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4J0"/>
    <dbReference type="STRING" id="595528.A0A0D2X4J0"/>
    <dbReference type="eggNOG" id="KOG2853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4J0"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4J0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="515" mass="55043" checksum="7151C32F42FC2AC6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Q2</accession>
    <name>A0A0D2X4Q2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344401.1">
        <property type="nucleotide sequence ID" value="XM_004344351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Q2"/>
    <dbReference type="InParanoid" id="A0A0D2X4Q2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="109" mass="11242" checksum="38F1D19AD818B2D2" modified="2015-04-29" version="1">MEVLNSTPISASQAGRQLATFLRHANALNVPATTASQLGVLEQGIRSHQQRVSGASADDSVSSDNGTAKTPSKHSSSSSKSADVMEMDTEQSAPAASTPKSSKKSKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X527</accession>
    <name>A0A0D2X527_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X527"/>
    <dbReference type="FunCoup" id="A0A0D2X527">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X527"/>
    <dbReference type="InParanoid" id="A0A0D2X527"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X527"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="136" mass="14940" checksum="2BBDA7AE7D375CF1" modified="2015-04-29" version="1">MVHVARKIGIGLTGFGIFFLLLGILMLFDTGLLAMGNLLFLSGVGLLIGWDRTIRFFFQRHKAKGTTCFLGGIFVVLCGWPVIGMCVEIFGFINLFGDFFPIVINFLRQMPVVGQLLNLPGIAQVVDKFTGSKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X541</accession>
    <name>A0A0D2X541_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X541"/>
    <dbReference type="eggNOG" id="KOG4303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X541"/>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="945" mass="100304" checksum="55865D3EE0E5CA48" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5B8</accession>
    <name>A0A0D2X5B8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_007374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343233.1">
        <property type="nucleotide sequence ID" value="XM_004343183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5B8"/>
    <dbReference type="STRING" id="595528.A0A0D2X5B8"/>
    <dbReference type="InParanoid" id="A0A0D2X5B8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="29021" checksum="934DB6D5E87035A8" modified="2015-04-29" version="1">MLLGSNLRRSAVAAAGYSRGSHLAPLPLQISAGAAAAAAAAAAAVSVAAVRGRSSLPQATSTSGPAAAQPVSQDPQATSTSSTPGIAVMAAVAGSLSRRLAQAADRMLASLYLIPAAAEEQGRGPHRLDFALAASSESPLAAEEHERSSLTESVMDVLREGFLWALPKRKTTPARKARRSTHKGLEPVAQITTCMTCGRPKHTHMLCGACFRTTQLPVREFRREELYKHIVTKSRGLKAWIERGYLTAKAKATVAQAAAAAPAPRPTSPSSAKQEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5E6</accession>
    <name>A0A0D2X5E6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic initiation factor iso4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342854.1">
        <property type="nucleotide sequence ID" value="XM_004342805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5E6"/>
    <dbReference type="FunCoup" id="A0A0D2X5E6">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X5E6"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5E6"/>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5E6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="219" mass="24600" checksum="41D2217E3DCDC5B4" modified="2015-04-29" version="1">MAAEGRQQTQTASAAAPQQQAQQAQPQQQQQALAPLMTSLSTRHELQFSWTLYYDNPPRDADWNNFKQYLTSVITFRTVEDFWGAINNIRPPSGLPTGANYSLFKGDVLPVWEDSANNKGGKWLINVNRKTARLDEMWLNTMLGLIGENFEVQDEITGAVCSLRPKGDRVALWTRTTDESVRVMGEKFKAAVQPDEPLNFMSHSDAGGSFKVKSKYIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5T1</accession>
    <name>A0A0D2X5T1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346395">
        <property type="protein sequence ID" value="KJE98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5T1"/>
    <dbReference type="InParanoid" id="A0A0D2X5T1"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5T1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40898" checksum="14BBFA78035B459E" modified="2015-04-29" version="1">MGAWGGGNPLAKTGAALPAKSGLEMIDVNDPAYAKLNEELSLNASQMGDGSKHTVVVSWTSLRANKIDGRGNEITKLLMEHIPDGCCGINFGPHELSIVFKHPNQATEACQQGIQFGMTTIYPNACLREVVLMLYNVPMHHSNEAIADMLNTKTGLKFEKCHRSIGKAPNGCPFETGTRIYYATLTSDVNVKQVIDKVPDSIQVTSASGFPRDVQIQVKGQPTKCFHCKQHHKYATCPTRRTQCNRHEVNENETTRLNTDRAETANNDGFVQVGPKGKAAKAPTQRAWPKPATAQPANQASTSKSSATATTTQPAARTTQIATTQPAAPRATAAASAAAAKANQTASSQAAPSTPQHPGQKRPASQLTPDGASRVHKQPHIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0B0</accession>
    <name>A0A0D2U0B0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_000241</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0B0"/>
    <dbReference type="STRING" id="595528.A0A0D2U0B0"/>
    <dbReference type="eggNOG" id="KOG1645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0B0"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="447"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112128" checksum="C73D99456FB899A2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2X4</accession>
    <name>A0A0D2U2X4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2X4"/>
    <dbReference type="InParanoid" id="A0A0D2U2X4"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2X4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="610" mass="68989" checksum="B8E39F76D91EF8CC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4J7</accession>
    <name>A0A0D2U4J7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364314.1">
        <property type="nucleotide sequence ID" value="XM_004364257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4J7"/>
    <dbReference type="STRING" id="595528.A0A0D2U4J7"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4J7"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U4J7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="724" mass="81175" checksum="025C5383BDFA8D4F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5N6</accession>
    <name>A0A0D2U5N6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5N6"/>
    <dbReference type="InParanoid" id="A0A0D2U5N6"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U5N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029711">
        <property type="entry name" value="Haus7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010604">
        <property type="entry name" value="Plant_AUG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14352">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14352:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06694">
        <property type="entry name" value="Plant_NMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="651" mass="72018" checksum="7AFA94D62B0A06BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7K0</accession>
    <name>A0A0D2U7K0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7K0"/>
    <dbReference type="InParanoid" id="A0A0D2U7K0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="696" mass="75390" checksum="BE6F9801F3D73ECE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBU1</accession>
    <name>A0A0D2UBU1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003453</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBU1"/>
    <dbReference type="FunCoup" id="A0A0D2UBU1">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UBU1"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBU1"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UBU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14295">
        <property type="entry name" value="UBA1_atUBP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="158"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="310"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="676"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="804" mass="87339" checksum="14DDB859CB6B8103" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UC23</accession>
    <name>A0A0D2UC23_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270329.1">
        <property type="nucleotide sequence ID" value="XM_011272027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UC23"/>
    <dbReference type="FunCoup" id="A0A0D2UC23">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UC23"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UC23"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UC23"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="216" mass="22939" checksum="6A236F8117D9FABC" modified="2015-04-29" version="1">MQAFIEKFRGAPNASGSLDQLFQQTTSHADPAAITTAANAANNASAAPAPGFMTPASLAQSARQLHSQMPSARSWTEFLNAKRLSRPAGMGDLSARLWVNISHFQANYFAIFVALVIYCILTSPTLFLSLLVIIAVMALIALRQGRPLHVGGKEYTSRDLYMAVATVSIPLLFFASAGSAVFWVLGASIFVIVGHAVFMEIDPAAHAAASGQPTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCA3</accession>
    <name>A0A0D2UCA3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348440.1">
        <property type="nucleotide sequence ID" value="XM_004348390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCA3"/>
    <dbReference type="InParanoid" id="A0A0D2UCA3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="112" mass="12734" checksum="074D4C32B87AB7D5" modified="2015-04-29" version="1">MVEVRIIRSVGSVISKLIQVTRGSVSEDATADLNQALAHLRDFEIEVSNEIPDPTSSRLFQDYVAQELLKVLRHKTQFGCFVFPKPHQTSRDLAAFFLERFQQKRIAADMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFA4</accession>
    <name>A0A0D2UFA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_004535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFA4"/>
    <dbReference type="FunCoup" id="A0A0D2UFA4">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UFA4"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UFA4"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UFA4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252764" description="glutamate--tRNA ligase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="75"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="438"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE93791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="572" mass="62753" checksum="A4DFCFEE2E8111E6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGP5</accession>
    <name>A0A0D2UGP5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGP5"/>
    <dbReference type="STRING" id="595528.A0A0D2UGP5"/>
    <dbReference type="InParanoid" id="A0A0D2UGP5"/>
    <dbReference type="OrthoDB" id="16405at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF16">
        <property type="entry name" value="GLYCINE, ALANINE AND ASPARAGINE-RICH PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="80"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="943" mass="95402" checksum="3234C5FE6987748E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIF2</accession>
    <name>A0A0D2UIF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIF2"/>
    <dbReference type="InParanoid" id="A0A0D2UIF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="29001" checksum="4ED40040FC41B940" modified="2015-04-29" version="1">MARGDRVSRTGRGGPAPRGNRGGHASTSGPNVQAFQGGRGGLASHSDQGSVSRRDDQASPPLIGNQPPPPRDPSQPHRPNGSQPPPPDDRQQTAEARWFQWRDKHLNLVHTTDRQTHSAAFVVLVNDDPNVSLLLFEKNETSPGWEMFGGKKRLLIVPRRREDPSRTAAREFGEEAGAALRLIKHEDLYDLEKEIHQHLVPKRSMLVVEGTGVLYVVRAPTLFDKLVQASGNHAPAARVVPYNSILANDRNSQETRSRIKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIF8</accession>
    <name>A0A0D2UIF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_005468</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346141.2">
        <property type="nucleotide sequence ID" value="XM_004346091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIF8"/>
    <dbReference type="FunCoup" id="A0A0D2UIF8">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UIF8"/>
    <dbReference type="InParanoid" id="A0A0D2UIF8"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UIF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="231"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE94926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="536" mass="60342" checksum="1EA19C21E91E0052" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJD8</accession>
    <name>A0A0D2UJD8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_005674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346347.2">
        <property type="nucleotide sequence ID" value="XM_004346297.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJD8"/>
    <dbReference type="STRING" id="595528.A0A0D2UJD8"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJD8"/>
    <dbReference type="OrthoDB" id="6417231at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJD8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="45"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="423"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE95196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="735" mass="81498" checksum="4C3C28E75A4F3680" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJK4</accession>
    <name>A0A0D2UJK4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Septin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346425.2">
        <property type="nucleotide sequence ID" value="XM_004346375.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJK4"/>
    <dbReference type="FunCoup" id="A0A0D2UJK4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJK4"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJK4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJK4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="111"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="414" mass="45762" checksum="36EB389EA78889A7" modified="2015-04-29" version="1">MVVQFTSQQEKAIEQAFNSIDTDHSGSIDRDELGTAVQKLLDRKVTDAEVDEMLAKADSDRSGSISLDEFKAMMADHLSRSTNWGKLRTALGGYVGFDQLQQQQNRKAMKRGFQFNLMVVGESGLGKSTLVNTLFRSKIARSTLAGAEDAKIPKTVEIHSVSHVIEEKNVRLRLTVSDTPGFGDHINNDGSWQPILDHINKLNEKYFADESAVVRNIAPVDSRIHACIYFIAPTGHSLKPIDIEFMKKLDKSVNIIPVIAKADTLTLEERAAFKERIVEDLDQHAINVYPNVNEDDDEEDKAINSKLSELLPFAVIGSDKEVIVNGQGVLGRKTKWGFIEVENKDHCEFSNLRDMLIRTHMQDLIDVTHFTHYEKFRAAKLRGGAPAPAAAPAQAAAPKAVVKVGGNSVADSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJZ0</accession>
    <name>A0A0D2UJZ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345466.1">
        <property type="nucleotide sequence ID" value="XM_004345416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJZ0"/>
    <dbReference type="STRING" id="595528.A0A0D2UJZ0"/>
    <dbReference type="eggNOG" id="KOG1776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJZ0"/>
    <dbReference type="OMA" id="CALWDGG"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19671">
        <property type="entry name" value="UBR-box_UBR4_5_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF159">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="437" mass="48333" checksum="B73507715A08522E" modified="2015-04-29" version="1">MLNGRSKQGPAEFDWRAMALGKKHQRKSIGFGAYDKKNKSHAHEIHIRELCVATGALGCALWDGGVVLARWIYENGAAFRGQTVLELGSGCGLPGVLAAHYAAHVTLTDYIDPVLDNLRYNVRLNSEDADADRGVDAEAAATSTTTSATRTGLDGDQPSSSSPPSSDPQEKTTNADPENTSASWAPVADSVTGEMQPWRRNLTPLVTVGYLDWDAVAAASASLAGLSLEERRKCALENEKAQRAEQEQRKLEHTKGLRCTIESLGREFTPQDWYHCTDCHGSDMTLGCCASCVKVCHAQHNTKFVEHSRFKCDCYSSEACVFEQQSHAQGINLHIEPVDVIIGAELTYSLLSVDSLIQVVDTFLKPDGVFYEVLSEDRDGVSEFVDRIQKRGFIVKSVPVPARFMGNYATRQWTYQDTETYRFFSFHRPGSKHRDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK63</accession>
    <name>A0A0D2UK63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK63"/>
    <dbReference type="FunCoup" id="A0A0D2UK63">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UK63"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UK63"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UK63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="9">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="218" mass="23336" checksum="819A5A0C34C0BAE0" modified="2015-04-29" version="1">MNQPDKPRYALVTVGTTSFDALIAVVTSKSFLDVLWRVHGIGRLVVQVGRGAIAPEDIATAPSDSHAAAEATSKQEEQPSLSSSSSSQRRVTRSQATSVNGGSAASDSARGTSHDHDRVQIEAYRFKPSLSKDMEHAELIIAHGGAGTILEALRADRKLIVVINEDLLGNHQHELAGQLSANGHLLQTSVKQETRTHRCNCKSRSTKATPARKPSAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKH1</accession>
    <name>A0A0D2UKH1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Corrinoid adenosyltransferase MMAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:co(I)rrinoid adenosyltransferase MMAB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_006021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:56796"/>
            <dbReference type="Rhea" id="RHEA-COMP:14743"/>
            <dbReference type="Rhea" id="RHEA-COMP:14744"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:56797"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKH1"/>
    <dbReference type="STRING" id="595528.A0A0D2UKH1"/>
    <dbReference type="eggNOG" id="ENOG502QS64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKH1"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKH1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="12">
        <location>
            <begin position="57"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE95581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="257" mass="27850" checksum="950EAD7ACD2AB0AA" modified="2015-04-29" version="1">MGGALQTRADSTLSSSSSSSSSSSSSSSSSAVPPSPRVAKKIVEAKSAAVASKMPKIYTKTGDKGTSGLFTGERRPKDDAVFEALGATDELTSALALAREFTLSVNENLAEQFETIQCVLQDIGSNVATPRTTEDKARKGFTEFDPTQVEELEQWIDAMDEQLPPLRNFILPSGGKASSAIHIARSISRRAERRVVPLVRDGEADEAAGRYLNRLSDYLFTAARYAAMLEHKPEIVYKTRAKVLEERRAKTVSQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR18</accession>
    <name>A0A0D2UR18_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_010131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR18"/>
    <dbReference type="STRING" id="595528.A0A0D2UR18"/>
    <dbReference type="eggNOG" id="KOG4428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UR18"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UR18"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="997" mass="108600" checksum="13CB68E231EE43AB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR32</accession>
    <name>A0A0D2UR32_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343185.1">
        <property type="nucleotide sequence ID" value="XM_004343135.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR32"/>
    <dbReference type="STRING" id="595528.A0A0D2UR32"/>
    <dbReference type="eggNOG" id="KOG4408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UR32"/>
    <dbReference type="OMA" id="YVHDKDC"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UR32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47463">
        <property type="entry name" value="F-BOX PROTEIN SKIP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47463:SF2">
        <property type="entry name" value="F-BOX PROTEIN SKIP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="320"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="455" mass="50185" checksum="78A63B5D7622B194" modified="2015-04-29" version="1">MTSLPTLPLELLELILGDPAVSVRDLVAVSATCRALRDVVELGSDAIWRRHCVATFSVDESNPDQDTDAPLDPRELTSIMSAAGGDGTQVDQERVHEAARARGIPSCALNPTLWRTADESRNDRAAAAGSPWRRRYIRHHLAFGHLLPTYTRMRRAWRIFTGWLRVNSPRIHGLLRPGTLGLLYPASKYASLTQAVLCLYRMNDGQNIGMPVFGTAGAYDEVRDLFFPRLRELDVLGRQLIRFMGAPCIVMPLLEPNADARDAPLLDLISFDSKGLDGFQTNSLTEWIEGYARDLASTRLIADDNGVIDLFPTFGEGVSTATTNGIQISMSSLPWPSRTRLHENGSEYGFIYKLRMVGTNAMPAGARYKLASRRWVIEQPDTPSETVEGPGVVGLYPEIAAGSHFQYCSATSYSTRMGGSMRGHFVMLDMNAPSYSFAAQIAPCVMTVPPITRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFG1</accession>
    <name>A0A0D2VFG1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364996.1">
        <property type="nucleotide sequence ID" value="XM_004364939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFG1"/>
    <dbReference type="STRING" id="595528.A0A0D2VFG1"/>
    <dbReference type="eggNOG" id="ENOG502R4TC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFG1"/>
    <dbReference type="OMA" id="ICIFIGC"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFG1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037663">
        <property type="entry name" value="Mosmo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186:SF1">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18800">
        <property type="entry name" value="Atthog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="177" mass="19070" checksum="32E228CE13B40063" modified="2015-04-29" version="1">MPSIVASSTIVASLGLFATSFILCVVAVSTPMWLDRESFGTHTRLGIVHQCWPSLSGSEYCMVAPIDQLPVAWQAAYCLMVVGMISLFGAILCSLGAWYNTHSMRIACNLGFFAACLLALATLIFPGGFSSPLVSGKAFKLPENVSVGYSYILFILSTLFAFLAELFAARIILPVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGI8</accession>
    <name>A0A0D2VGI8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_000556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365427.1">
        <property type="nucleotide sequence ID" value="XM_004365370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGI8"/>
    <dbReference type="FunCoup" id="A0A0D2VGI8">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGI8"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGI8"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGI8"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="249" mass="27961" checksum="E4405A060CCB9C74" modified="2015-04-29" version="1">MAARDESTLVLFDVDGTLTPSRLIISPQMKQLLQRLRERVNVGIVGGSDLPKIEEQLDTKTIGEDYDYVFSENGVVAKLHGENAPAQSVVKFLGEENLQELLNFVLRYIADLKIPKKRGTFIEMRQGMINISPIGRGCTHAERLEFFELDNKQGIRAAMVKALQEKFAHLSMKYSIGGQISIDVFPIGWDKTFCLTHLEPGKFKTIHFFGDKTSPGGNDYEIFSHSSVQGHTVLNPDDTAVQLNQLFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ58</accession>
    <name>A0A0D2VJ58_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-box carrying protein isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349916.2">
        <property type="nucleotide sequence ID" value="XM_004349866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ58"/>
    <dbReference type="STRING" id="595528.A0A0D2VJ58"/>
    <dbReference type="eggNOG" id="KOG1675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJ58"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJ58"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="251"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="45994" checksum="2062CFC4BDFC3A78" modified="2015-04-29" version="1">MGSCLAKPMDGGSSSSNDPYAARSIHQQHKATEVASTAAASTSPASQRPEMLQVDVESPRDGTGTERRRAGSKLLSRMPSLSGAKLTKSRQDAPASAAGSGQDPSQSSQTDTAAPSVDDLVQHISEREPDNSNRRESLFLAAVNQSAADPSPLSYSNSKRKKKANSVVITDTKTKFNSTSTFFVDATVSQPDLDETFKCVALAIYYCMEAGHKVETPHFVDIFDEKKHPLAKGTNFDHYDKLMASEEKIYQFIKTLFVSAALTAECAIITLVYVERLIMSANLTIHATNWKRITLGAVLLACKVWDDQAVWNVDFCTIFPDVTVEDFNKLEKYYITQIMFNVSVPASVYTKYYLDLRSLAEDTNRTFTLKPLTQEQAEKMEAMSMAKEREAKNLPLRKRAKSCELYEPKSAMAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLD3</accession>
    <name>A0A0D2VLD3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLD3"/>
    <dbReference type="InParanoid" id="A0A0D2VLD3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="101" mass="10342" checksum="93F8E3E730EA900E" modified="2015-04-29" version="1">MGGSASKQPGISSFPLPADRCAVNLRNGSVVVTAQPAPYEAPPPVPAPPPVVAPAQWALISINHCGHAETSSRRSAASRRSAASRRSAASCRRRAGPAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMD1</accession>
    <name>A0A0D2VMD1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349215.2">
        <property type="nucleotide sequence ID" value="XM_004349165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMD1"/>
    <dbReference type="STRING" id="595528.A0A0D2VMD1"/>
    <dbReference type="eggNOG" id="ENOG502QR7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMD1"/>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMD1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052803">
        <property type="entry name" value="Cilium-Associated_Jouberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499:SF1">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="3">
        <location>
            <begin position="511"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="896" mass="96146" checksum="A9354E8BDCF8B42F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPB1</accession>
    <name>A0A0D2VPB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364122.1">
        <property type="nucleotide sequence ID" value="XM_004364065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPB1"/>
    <dbReference type="eggNOG" id="KOG3209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VPB1"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VPB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF68">
        <property type="entry name" value="AGAP003128-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="575" mass="63613" checksum="7FE28BF2E20EA7F3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ08</accession>
    <name>A0A0D2VQ08_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ceramide kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348433.1">
        <property type="nucleotide sequence ID" value="XM_004348383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ08"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ08"/>
    <dbReference type="eggNOG" id="KOG1115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ08"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ08"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="409"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1194" mass="123562" checksum="B595266DF58C9569" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQH9</accession>
    <name>A0A0D2VQH9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger RAD18 domain-containing protein C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQH9"/>
    <dbReference type="STRING" id="595528.A0A0D2VQH9"/>
    <dbReference type="eggNOG" id="KOG3931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQH9"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="4">
        <location>
            <begin position="68"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="526" mass="57575" checksum="07001A95D58D6DE1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR85</accession>
    <name>A0A0D2VR85_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin Seh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347983.2">
        <property type="nucleotide sequence ID" value="XM_004347933.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR85"/>
    <dbReference type="FunCoup" id="A0A0D2VR85">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VR85"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VR85"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VR85"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="321" mass="36337" checksum="0B5D71DB4AEF1AE4" modified="2015-04-29" version="1">MMRITNNVDTKHEDIIHDVAYDFYGKRMATCSSDHRVKIWDLGDDGSWNCTYTINKAHNASVWKVAWAHPEYGQVVASCSFDRTVNIYEEQVEEDSKKQSTWLRKAMLVDSRDTVRDIKFAPKHAGLKLATCSADGYVRIYEANDVMNLTFWPLMEEFEARKEGCNCISWNPSKYHSPMIAVGSDDVLIRIWEYNETVRRWQCLDTQIDHSAAVYDVAFAPNVGRSYHLLASCSKDKTVKIWKLIPPGAAGPGADVVSSGKLTVQLAATFKHDSEVWRVEWNVTGTILASSSDDGTVQLYKLGMQPDEWRRISVVNGTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS59</accession>
    <name>A0A0D2VS59_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347344.1">
        <property type="nucleotide sequence ID" value="XM_004347294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS59"/>
    <dbReference type="FunCoup" id="A0A0D2VS59">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VS59"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VS59"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VS59"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="299" mass="33403" checksum="994C943447939F2D" modified="2015-04-29" version="1">MSALVESNLPALTLLARGKVRDVYRIDDKSLLFVATDRISAFDVVMNNGIPGKGKILNQISLFWFDLLKEVVPCHLITAEIDEMPEVVRQYRDQLEGRSMLVRSLNMLPIESIVRGYVAGSGWKEYQQSNTICGIALPAGLTESARLPQALFTPSTKAELGTHDENIHPDKAAEMIGKDLADRMAATALELYTKASEYALTRGIIIADTKFEFGIHPETNALILGDEVLTPDSSRFWPKDKYATGRAQDSYDKQYVRDYLESIKFNKKDPVTLPEDVVQNTLAKYQEVFTILTGRKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSG7</accession>
    <name>A0A0D2VSG7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347479.2">
        <property type="nucleotide sequence ID" value="XM_004347429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSG7"/>
    <dbReference type="STRING" id="595528.A0A0D2VSG7"/>
    <dbReference type="eggNOG" id="ENOG502S55Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSG7"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="28280" checksum="681F58A4BD57B79F" modified="2015-04-29" version="1">MTLTETTVTYHDQGSTLIGFMAAPATIAAGTKLPAVLIIHDWKGIGDYVRERARILARKGYVAFAVDQYGDGKHAATHEEAAALMQAYTKDSTFALNRTLAGLNQLIAHPHVDASKIVCYGYCFGGTCCLELARHNAPVAGVAGFHAGLQSFSGASNKNIKTRVAMFHGYNDPWISREAVQNFTKELSEAQVDFTFVDFGNTVHAFTVPGINNPPAMIYNESSDKQSWAYFEFWLHHITLGGAKSGAPDCCNKGDAGAASCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSN8</accession>
    <name>A0A0D2VSN8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_004810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347561.1">
        <property type="nucleotide sequence ID" value="XM_004347511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSN8"/>
    <dbReference type="STRING" id="595528.A0A0D2VSN8"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VSN8"/>
    <dbReference type="OMA" id="WEISAIV"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VSN8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="68"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE94122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="662" mass="73655" checksum="1E94E83952E6F0B1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTP3</accession>
    <name>A0A0D2VTP3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346947.1">
        <property type="nucleotide sequence ID" value="XM_004346897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTP3"/>
    <dbReference type="STRING" id="595528.A0A0D2VTP3"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTP3"/>
    <dbReference type="OMA" id="RQSQNYY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTP3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="294" mass="33409" checksum="CB2F1CA44D7B6714" modified="2015-04-29" version="1">MDYYCVLEISRTATTDDVKRAYRKQALLWHPDKHPEETRGEAEARFKLVAEAYEVLSDPVKRAEFDNYGASGATSNTAQSNPRAQDQYQYQQQQYRTTHHFVDPFELFAQFAQFDPMFAQVLNHHMSMTQSAAFGGGFGMPFGAIPPRSFQQQHAQLQQQQLQQLQQQRLLQQQQQQQQQQQQQQQQQQQQPYQQQMQPFAMQQQQQMQTGFGLPMGMQSTFGMPMMMGFGGMGMGPMNMGMGGGMVSTSVSTRIMNGQQVTERRETVNGQTTVTIEQNGVVISRTVNGVAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU29</accession>
    <name>A0A0D2VU29_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346107.1">
        <property type="nucleotide sequence ID" value="XM_004346057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU29"/>
    <dbReference type="InParanoid" id="A0A0D2VU29"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="295" mass="32521" checksum="5737F9015A7649A6" modified="2015-04-29" version="1">MSYAQEKLTVVGTPCTVAVMDVANTVLLLENQTGTTIQAKTGSAESELRTFLSIYPGAGQQPSPGESRLTIQWGSGDYLSNSVGNLNSIQMNIRDNSGTVDYFASIGSGYWWKEGDDHSYSFDQARASGIVFRTRHTLPHDSEPHSDDQWHCKDVLTIFPYVNNSVVAHAMGTYKGKCDFGVDDQNDLRQFQFIQFGNVPSYPSTTEQLPWNEIEKDNSLYPVALDGVYIKDNVIVPALSGNSSEYMAFTWWMDNMSPFITTGASTVNYASGCLDCPYACVTVMSCSDEDTFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY66</accession>
    <name>A0A0D2VY66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDB1- and CUL4-associated factor 15 WD40 repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344537.2">
        <property type="nucleotide sequence ID" value="XM_004344487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY66"/>
    <dbReference type="InParanoid" id="A0A0D2VY66"/>
    <dbReference type="OrthoDB" id="5960162at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038914">
        <property type="entry name" value="DCAF15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541:SF1">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14939">
        <property type="entry name" value="DCAF15_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 15 WD40 repeat-containing" evidence="2">
        <location>
            <begin position="82"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="507" mass="55359" checksum="069BA8AC169CD7AB" modified="2015-04-29" version="1">MSALPLPHVLLYRELHGGLPLLPAPPPRLRQTAAPPAAASAVTQPLSSAGSERRRRRRQSELLRRLSGPATSLTSKRLLAARLFPRPLPSANVPLRAIHDAEGQIVQGCVLLGFSGDGRFMLSYMSEVAPARLQSSFSFFESVTLFTYSFVTWRFDPHQPLACHSKTPLFRGTAHKTLLLQVAESPCGRRYVITGFEQEHAADGLACRNCYMSIVSHTPDEQPGVGPQKPVYDRVCEIALPSPLSFITSGVSLVLDDLYVFNTGEQLLVVDFRTDPQASLVGSNGTEASRPVSDQLHAAIDTTNSPLQRLQTPAALVEQPSEILTRRISLEGILANLAAHPKFGFGRECLRVIDYNGYLIDVCRQSRQAILLLACVAKSTNQPGHTPVLPPGEEPVHVLTYQLMIPLDGEAEPSSRRGLRLAGFERISMRQAECTTAALIARTLRRAQALIHQLRVVSAEPAQQVFSTWTNRTVLAGQSLPGLRHPLWPLAVTMTSPAVGVRSMPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZF6</accession>
    <name>A0A0D2VZF6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fukutin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343543.2">
        <property type="nucleotide sequence ID" value="XM_004343493.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZF6"/>
    <dbReference type="STRING" id="595528.A0A0D2VZF6"/>
    <dbReference type="InParanoid" id="A0A0D2VZF6"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZF6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055105">
        <property type="entry name" value="FKRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF31">
        <property type="entry name" value="RIBITOL 5-PHOSPHATE TRANSFERASE FKRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22921">
        <property type="entry name" value="FKRP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FKRP stem" evidence="4">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FKRP stem" evidence="4">
        <location>
            <begin position="364"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="3">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="82565" checksum="C7BC9FED678E43A1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W118</accession>
    <name>A0A0D2W118_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_008017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342618.1">
        <property type="nucleotide sequence ID" value="XM_004342569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W118"/>
    <dbReference type="STRING" id="595528.A0A0D2W118"/>
    <dbReference type="eggNOG" id="KOG4612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W118"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="166" mass="17336" checksum="7F4DC7578A3D7850" modified="2015-04-29" version="1">MLATRSAVRLGRAAAAAALASPSQQLQRLTASNLTAPLQQSQQQRSFSSLLLNGGSRLRMGPTGALSLCSSSSSSLSPSSSSGALLGASTAITVQGGSLGCAAPRLAASALLAAPTCVRHATFGREYQPSNLKRKRKHGFLLRMSTAAGRRVLLRRRLKGRRKLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1H3</accession>
    <name>A0A0D2W1H3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_008154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342755.1">
        <property type="nucleotide sequence ID" value="XM_004342706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1H3"/>
    <dbReference type="STRING" id="595528.A0A0D2W1H3"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1H3"/>
    <dbReference type="OMA" id="SKPASHY"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1H3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="9">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="626"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="862"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE98142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="95974" checksum="A8A5C46A6F32D520" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGD5</accession>
    <name>A0A0D2WGD5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364995.2">
        <property type="nucleotide sequence ID" value="XM_004364938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGD5"/>
    <dbReference type="STRING" id="595528.A0A0D2WGD5"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGD5"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGD5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="84482" checksum="21CB57C358697A43" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI12</accession>
    <name>A0A0D2WI12_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI12"/>
    <dbReference type="InParanoid" id="A0A0D2WI12"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="175" mass="18167" checksum="27832EBE6118ECB8" modified="2015-04-29" version="1">MGDDGTNVENRGGWPISDVYNWVAVMPGNAMPSPFRRRALTASDACDPFVTRDSKPMSLADCIAARRAGLGTPVLGGRAGSELNCCLVGGGGGCCDCCRRSDVLCWWGGGGCCFRCCWRAVPTLLRCSDSPNSAESSCSFIIARLPGCVMNGTCAPFVATGSMLSSTVVASAVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI26</accession>
    <name>A0A0D2WI26_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365765.2">
        <property type="nucleotide sequence ID" value="XM_004365708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI26"/>
    <dbReference type="FunCoup" id="A0A0D2WI26">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WI26"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI26"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI26"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="844"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="992" mass="105259" checksum="D15AE207297888D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WIX3</accession>
    <name>A0A0D2WIX3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WIX3"/>
    <dbReference type="InParanoid" id="A0A0D2WIX3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="253" mass="28603" checksum="2D1167548F9F3216" modified="2015-04-29" version="1">MRKVMVRMRNLLAMVRHRARIWPVVHLVELVEGKHQEADAANQEEHAAHSTHPIHEGFGAGRALAVFHAVGERGRVVDADARRAEAGYNKECRANGKRERAPHVLVLNVGPERRLVLQGSVQGEDAGAREEKEGRDKVHVARRLGMVAADLQRRHRDVQRASHDKQKDGRVVEGARPLVRTLPKHGIQCACFQEHLCQQEEGDAYNHGNVERCERLWQVFHQNGQDGKPDRAHHEHGRANQVQIAICASYEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ15</accession>
    <name>A0A0D2WJ15_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ15"/>
    <dbReference type="InParanoid" id="A0A0D2WJ15"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="62976" checksum="6CA0052113DD6ED0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ87</accession>
    <name>A0A0D2WJ87_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aminomethyltransferase</fullName>
            <ecNumber evidence="10">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="10"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365723.1">
        <property type="nucleotide sequence ID" value="XM_004365666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ87"/>
    <dbReference type="FunCoup" id="A0A0D2WJ87">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJ87"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ87"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ87"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000014">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="11">
        <location>
            <begin position="40"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE89368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="43270" checksum="B7B4A0B700D4327B" modified="2015-04-29" version="1">MLCRSATAVAASIVARSAARSTAVRCGSTAATGPSKRTALYDFHVAKGGKMVPFAGWDMPVQYSDLGIIASHHHTRENASLFDVSHMLQFRLHGAQRVQFLESLVVADVAGLAETAATLSVFTNEKGGIIDDTVISNAGQTLYVVSNAGCADKDLAHLNAQLARFNAEKKADVRLQIVETALLALQGPKAAAALQALVPSKDLSKLPFMHGVDGVTVDGVANCRVTRCGYTGEDGFEISIPNQHAVQIAEKLLTNPAVKLAGLGPRDSLRTEAGLCLYGNDIDETTTPVEAALKWTIAKRRREQGGFLGDKVILQQLKDGVSRTRIGLVADVGPAARQHSKILTADGEVIGEVTSGCPSPSAQKNVAIGYVPPAFSKNGTALQVEVRGKKYPAVVSKMPFVPTRYYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJL6</accession>
    <name>A0A0D2WJL6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJL6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJL6"/>
    <dbReference type="eggNOG" id="KOG2087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJL6"/>
    <dbReference type="OrthoDB" id="28057at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJL6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266410" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="58922" checksum="AC12421265B9DBBB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJX6</accession>
    <name>A0A0D2WJX6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RasG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364630.1">
        <property type="nucleotide sequence ID" value="XM_004364573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJX6"/>
    <dbReference type="STRING" id="595528.A0A0D2WJX6"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJX6"/>
    <dbReference type="OMA" id="CESINCP"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="193" mass="21578" checksum="5CF7AE98015F338D" modified="2015-04-29" version="1">MTDIKICVVGSGGVGKSCVTVRFLKQKFAEYYDPTIEESYRKPVTVDEKDYELEIVDTAGQDEFASFRDSSLDYGDGFLLVFGINSPSSFAELQELRKKILLMKEADSYPMVIVGNKKDLPPDQRTVSEAEVQAFCESINCPYYETSAKTGLNVEEVFFEVVRQIRKSKPELNKPGAAVAEKKEKKGGKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK30</accession>
    <name>A0A0D2WK30_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349824.2">
        <property type="nucleotide sequence ID" value="XM_004349774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK30"/>
    <dbReference type="FunCoup" id="A0A0D2WK30">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK30"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK30"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000007">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="307" mass="34807" checksum="862EE186F09CBFF5" modified="2015-04-29" version="1">MTAFLQSKLHGIGEFLTPVLKASKFKETGVITPEEFIAAGDFLVFKCPTWSWESGEESKRRNFLPPDKQFLVTRNVPCFKRVKSMEYSENDERVVEGDDWVETHIGHESLQKTDLQEIPGDSSAITAKSHASAAKDDDDDDVPDIEDADGDDDDIPDIDEFEEDNLEACDPSALAAPSAAAGDADDNILRTRTYDLYITYDKYYQTPRLWLFGHDESRKPLSVTKMYEDFSQDHAKKTVTMEAHPNLSITMASIHPCRHSNVMKKIISNVEVAGKELGVHLYLMIFLKFVQSVIPTIEYDYTREFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WL51</accession>
    <name>A0A0D2WL51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270197.1">
        <property type="nucleotide sequence ID" value="XM_011271895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WL51"/>
    <dbReference type="STRING" id="595528.A0A0D2WL51"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WL51"/>
    <dbReference type="OMA" id="LMILVYF"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WL51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000042">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="122"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="531" mass="58905" checksum="2144F74FEE305F0E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMA6</accession>
    <name>A0A0D2WMA6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMA6"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMA6"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="806"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1399" mass="147832" checksum="72EFBCCF951646EF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMR1</accession>
    <name>A0A0D2WMR1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270224.1">
        <property type="nucleotide sequence ID" value="XM_011271922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMR1"/>
    <dbReference type="InParanoid" id="A0A0D2WMR1"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMR1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="248" mass="27656" checksum="563A7D65EEF4DB9A" modified="2015-04-29" version="1">MNPLGTPGGVVSPRNERAFDLLREARQAKDADSPRFFKAAVLKTYFTPCADISGPGGAGAKETKPSIRQLAAIFEVPRSTVGNWIAHHRHQADLFARSTLDQAVDLVQDDAVPGDHNVFLRSEELKIVNYLVRSAFAHVALTKPDTIELFMRLSQAPRPDGKPRRQFGPNGPSESFLERFFAEFSDELRWITAHSIETIRTAAMNEETLRSFFERLQELCDKSGGKLWAEPGRIFSCVRKLSASLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN46</accession>
    <name>A0A0D2WN46_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN46"/>
    <dbReference type="FunCoup" id="A0A0D2WN46">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WN46"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN46"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN46"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="10">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="356" mass="41640" checksum="7F9F56786ACFDA43" modified="2015-04-29" version="1">MTNPALTFHPEFAHQLFGDNERIFGYRNLNIKLFYTASAMHPLFSMTYSEKVVKRKGEAGADDVVKLIGDILPENHARDEATFKQRLSEDAAFVPMGELISSYQREGDDSTFEVYRADCSTQRLAEFHTRIQTFLMWFVDGASFIDLNDNKWTVFLVFKRVANVSADGSNPTRHLFVGYMTTYDFFAYPDRLRPRISQVLVLPPYQKQGHGREMLQAFYRVARSRAEVWDVSVEDPGLAFATLRDRIDARNCLSELPELYESLPDDLSEDIVSQTQQKLKLNKKQIRHIFELLKLNQIDRNDEAQYKKYRLMIKKRLHRQYNTDLVQLEMAADRIKVLDKLYTEIEQYYTDILRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN51</accession>
    <name>A0A0D2WN51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348657.1">
        <property type="nucleotide sequence ID" value="XM_004348607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN51"/>
    <dbReference type="InParanoid" id="A0A0D2WN51"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40631" checksum="0304465256B2CEC8" modified="2015-04-29" version="1">MTNTTWLKTDVTHYYNPLEVWVVSMGALLLGAQLCMALLLVVKREWKPFKAKQPAVLMVAAVAAIIAFLGEMHGEFLLPQEGTVMGACYFWKQWVYATFGLGLFATAHLYRFYTRWVVLHILNSRLLSTSRKLDRRVIQLAGAVVIFLPVVLLSIIVTTAGDMGIEPIVMANGELKNVCVTKSKVMVYSINAAMGLYLFALAGWWTYTLRNVRVSFNEYSSARSGLVSSLVCLVVYILIIFSLDNSTYYYRSLKLALNIGITTPIFAAIATGAVLDWLTNPERAESAFEAGMAMTMLTHMPSRTKSSFALNPEVETSTAARKSSGASNSDSARSAPPPADVSDYAAEMEEEEGPNFELDLGVVTVTPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNK2</accession>
    <name>A0A0D2WNK2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363363.1">
        <property type="nucleotide sequence ID" value="XM_004363306.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNK2"/>
    <dbReference type="InParanoid" id="A0A0D2WNK2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="927" mass="100584" checksum="8F7D466CF2406EEA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPI7</accession>
    <name>A0A0D2WPI7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348420.1">
        <property type="nucleotide sequence ID" value="XM_004348370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPI7"/>
    <dbReference type="eggNOG" id="ENOG502QRX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPI7"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPI7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="48373" checksum="0453164C3531B731" modified="2015-04-29" version="1">MAEFNTSAFLLDESGMDDPAFLPAANPYAVDASAAHDGSTASDPIHAAQGFHAAPIAFDLTPTGSIHADPHAKLSEVQQLHTQRAARFAIPVVQAKPSVVWNPTDYAKQRYANKAGTFSTGIDLLAPAERQKIEDRAKRFGKVSNVTSDSLKQEEAKIKRAQKFGQLSAMASNDSGMDVDAGAVKFEPSAAATVRFDAVYMYGTDQMSSGDVLKYFGEYGPAFVEWINDSSCNVVWEDTVSAGRALLGLSVSPSSIALGIDPLIQAANDGVPPSLEWRRGVASAKASDIYLRFATSEDVKRFGAANESVYYQLHGRPNAHPKKRFHSQQNQKPHATAKHPQQQNQHSQQQLQQNDAAEGTRAAGRRNRKERAAAARDNLHNTIRAMTTDEDNALAVSSKSGEKSTARGCRRWVGIGTSGIVAAALHAAAASSAAASVAPNVTAEPASAEFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPL4</accession>
    <name>A0A0D2WPL4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348008.1">
        <property type="nucleotide sequence ID" value="XM_004347958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPL4"/>
    <dbReference type="InParanoid" id="A0A0D2WPL4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="439" mass="43890" checksum="692CCBF9B89E953E" modified="2015-04-29" version="1">MASSSSWSSVAGAAVAADPLSAAAVMARLDHLWNAAHSVCATSPAVARTMMYEFLALARAASVRLPGAVTRRVCTCCGNMLLPGLAGTQVRLVATSIKKKSKKSKSMAQLKQAESSRVNGRTTSGSTNSDTTTNAAAGLGKPAAATASKRTLRRRAMRSHHGMAADRSEPGKATPANASGKPNRQPPTSTPSTNARPAKARRRQRDYIIVKHPGENANEGNAGPSAPFKFSLTDPFGINSAATAQPVPVNHLHVTCGACSTRHIHPGGFGPTRRGAQSAAAAAAVVAAGATPPPQRATAAVPLTVARSAPASAVQSPAASPKPTPGGTMSPVPSSSSSAVPAVAAVASALHAKSLPASALTSRQASPFATPTSSVPPSPAFGKPAGSPSTLPAKPAPAKPAAGKSKSLKALLVQSKAPAGGQPPSDSGGASLLDFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPV2</accession>
    <name>A0A0D2WPV2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363436.1">
        <property type="nucleotide sequence ID" value="XM_004363379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPV2"/>
    <dbReference type="InParanoid" id="A0A0D2WPV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="179" mass="19704" checksum="202A29E6D2F5D1D8" modified="2015-04-29" version="1">MSQNQARKSPAISAPAPQIADPAVWQLRVAILRGSKPSDADRMIDIRVPVADPSQPLLFSALREALENDRPVEAKYRESPIFKFYNTATNTWYEDEEPVVAKVVHTFAGFRGAGVTKQKTKPKISSWRKLHLAAERRAQQALKAKQTLPEAQPPPPPAEAEAEASPAVVEAPLRPEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPX5</accession>
    <name>A0A0D2WPX5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363488.1">
        <property type="nucleotide sequence ID" value="XM_004363431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPX5"/>
    <dbReference type="STRING" id="595528.A0A0D2WPX5"/>
    <dbReference type="InParanoid" id="A0A0D2WPX5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="655" mass="73259" checksum="A370EE2F4497FBF5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPX6</accession>
    <name>A0A0D2WPX6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348156.1">
        <property type="nucleotide sequence ID" value="XM_004348106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPX6"/>
    <dbReference type="FunCoup" id="A0A0D2WPX6">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WPX6"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPX6"/>
    <dbReference type="OMA" id="EHMGSKD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPX6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="116" mass="12877" checksum="C6044972A8125B14" modified="2015-04-29" version="1">MSNQSQGIQALLAAEKSAAEIVAKARKRKATRLKQAKDEAEAEIAAFKSEREAQFQAHVKAHEGDTTQIAQRLKEETNTKLVAIDNDAAQHKQAVINKLLEYVCDVKAELHINVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQH8</accession>
    <name>A0A0D2WQH8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347396.1">
        <property type="nucleotide sequence ID" value="XM_004347346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQH8"/>
    <dbReference type="FunCoup" id="A0A0D2WQH8">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQH8"/>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQH8"/>
    <dbReference type="OMA" id="ARCADHH"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20433">
        <property type="entry name" value="Tudor_TDRD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000018">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000002">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047386">
        <property type="entry name" value="Tudor_TDRD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="334"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="526"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="731"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE93940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="913" mass="99198" checksum="ADEE7A5210E25FC5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQW4</accession>
    <name>A0A0D2WQW4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347581.2">
        <property type="nucleotide sequence ID" value="XM_004347531.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQW4"/>
    <dbReference type="STRING" id="595528.A0A0D2WQW4"/>
    <dbReference type="InParanoid" id="A0A0D2WQW4"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQW4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23471" checksum="0406EE118C89C1AC" modified="2015-04-29" version="1">MSFRYEVLRDESDMPATPHEEIQLTPVSSSSTAAAAAAVVEEEPLPVYQPNPTFSDAGTPHMPLPTYEQVQSDKAREFAASSAAAVAATNAELMHEAEALVGTDSTFLMSFFVCLIFDILGVIFCMCFGSSAATKFGVVAGLGSALLARCAFVMYQAFSPAVVPEDDKYHQSYVKNTFPIIALLGFLLMIYGFGSYRRAKLALRRRIEQLSSAVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRK7</accession>
    <name>A0A0D2WRK7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sphingosine kinase SphK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347368.2">
        <property type="nucleotide sequence ID" value="XM_004347318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRK7"/>
    <dbReference type="STRING" id="595528.A0A0D2WRK7"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRK7"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRK7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF54">
        <property type="entry name" value="SPHINGOSINE KINASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="6">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="815" mass="85593" checksum="5644DF830B0813B9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS27</accession>
    <name>A0A0D2WS27_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347588.2">
        <property type="nucleotide sequence ID" value="XM_004347538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS27"/>
    <dbReference type="STRING" id="595528.A0A0D2WS27"/>
    <dbReference type="InParanoid" id="A0A0D2WS27"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS27"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="112"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="36255" checksum="D07E15D76EB338FE" modified="2015-04-29" version="1">MVVRADRLPVTFMGLAIVYGAVTTLWCLLPTLSETLTQPSSSSVIRRLVLGTTLGQAFNVIALLYLGVSMTFNWIMSIVATSFNHPHDAADSNHASSHEHAHGEAAIHQATHSRTFCAACGQQRPLRTHHCSACNRCIARRDHHCFFVGTCIGQENHRYFLSFLAFSWMACTWVAVLTFCLPIPTADSWWLAVAIGFAPWVRIALVQLGVLNLAAAGPVVPMSLLILRTLTCTSSIAALLMLVYQLRAIVQGQTVLERRRQTASAAFEDLGVKANLQAVLGVHPSWWYSWIVPHYTNAAHAQQLRAVFQKAQGPPSTNELPNSQLVKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSE2</accession>
    <name>A0A0D2WSE2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270561.1">
        <property type="nucleotide sequence ID" value="XM_011272259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSE2"/>
    <dbReference type="eggNOG" id="ENOG502SG4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSE2"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="84" mass="9462" checksum="213FC1B5EBFE8E25" modified="2015-04-29" version="1">MVVGATKQLLKENPPLIPLFGIIGLGLVGAGYYVGRLSMGSHVVWDRKNPHPWIHTRQDDHDKFIDLRDERKKIMDAKAGNNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSS9</accession>
    <name>A0A0D2WSS9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345395.2">
        <property type="nucleotide sequence ID" value="XM_004345345.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSS9"/>
    <dbReference type="STRING" id="595528.A0A0D2WSS9"/>
    <dbReference type="eggNOG" id="ENOG502RZ8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSS9"/>
    <dbReference type="OrthoDB" id="10262596at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSS9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="entry name" value="Glycerate kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="entry name" value="Glycerate kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00045">
        <property type="entry name" value="glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="Glycerate kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="42118" checksum="0E62BF65A025A3C6" modified="2015-04-29" version="1">MAAVARSQPMRILVACDKFKESLAGPAVNAAIAQALQHALPNCIVSKMCMSDGGDGWIDSLRSPLQLEIQQVQVKGPYGKPVTGQIGVCHSQRLAVIEMAAASGLELTTAAERNPLHASTFGLGQLIKAACATDCSELLLGIGGSATNDGGIGALHALGLQVELRDRATPEQITGRDLQHIQRLSLPGCDWAEMQSMSVAARAARARQVLLGRSDRVVRVACDVTNPFTGPQGATAVFSAQKGATAAQQVELEAGMVNLTKHLELLTGVSVEVMPGAGAAGGVGGGFAAVLGAELQRGVVLLSRTLGLERAIADADLIVTGEGSYDAQTFSGKVVSHVKDLGRQYNKPVVVVCGVSKVPEVSNEAVLQLTSQFPLDACMHDTAQCLEGLIKRNSGLFERLLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTI5</accession>
    <name>A0A0D2WTI5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTI5"/>
    <dbReference type="InParanoid" id="A0A0D2WTI5"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTI5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="911" mass="100234" checksum="C2012C2DA69AD144" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTQ1</accession>
    <name>A0A0D2WTQ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRP2 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345073.2">
        <property type="nucleotide sequence ID" value="XM_004345023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTQ1"/>
    <dbReference type="STRING" id="595528.A0A0D2WTQ1"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTQ1"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTQ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000013">
        <property type="entry name" value="cysteine-rich protein 2-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="370"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="514" mass="56615" checksum="BBE6D4F247AEA0EA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTY5</accession>
    <name>A0A0D2WTY5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTY5"/>
    <dbReference type="STRING" id="595528.A0A0D2WTY5"/>
    <dbReference type="eggNOG" id="KOG3973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTY5"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTY5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="437" mass="47046" checksum="C6F7E5C215BE1EF6" modified="2015-04-29" version="1">MWTFYFVKAKLVDYKGNTPKLMVPVRIVPKAPNVVMPIVATQTSALIGLAKRQPFYQTATVGRNTLKVNTTVTRVELWQKQIGDADARAIAETLKVNKTVTCIGLGENQIGDAGASAIAKALKVNTTVTTVDLGQNLIGDAGAQAIAEALRVNTTLTRLNLSCNYIGDVGIQAIADAHEFNSTQINLTIGNQSNPLTTTDGDVGTPLSALAFALQVPVVASASDGGRATLTQDSLLKLLNSCQQSIVRLLGSLPSTHLGEPLLHKKLTSEHHARLTRINQDLEQEYTLRRRMLLKRLDVTVQSFEWSTRAQSKLDALQSAFQTQRTKLSPVAHIDVYAVLAARSNLLRITKASDESTRRKVRSSLYQVVMGKVPDRGGRAKEARGARMPAFAKRDAAVSEASGSGSRGGHRGQGQGHGQGGHSKHGHNNNKGKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WU66</accession>
    <name>A0A0D2WU66_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11 gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WU66"/>
    <dbReference type="STRING" id="595528.A0A0D2WU66"/>
    <dbReference type="eggNOG" id="KOG4186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WU66"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WU66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026510">
        <property type="entry name" value="PEX11C_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="242" mass="27395" checksum="757E2511A7093161" modified="2015-04-29" version="1">MAQLHIWSTLLETKAGRDKVFRTVGYSAKLISGLLVRFKIKKLQTLSEAISNLRVMTRLLDGVSMVTESIDYGTGSSEPDVLVRVCNVMQNVLYLLYYPCEHIAWAGSVKLMTVDVNKWYDRSDVFWVFALIFSLVSYIHLLRKLYVQERKLAREAARKTGPAVGSPEYVKMHKAIKDRRKNLVLGFVQEGCDFMNAIHWLPSGYLWAEKFPPYVVGFFGSISSFIGLYKNYRSAAAASASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUB1</accession>
    <name>A0A0D2WUB1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase 8 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345518.1">
        <property type="nucleotide sequence ID" value="XM_004345468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUB1"/>
    <dbReference type="eggNOG" id="ENOG502QTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUB1"/>
    <dbReference type="OMA" id="WAATNIT"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF47">
        <property type="entry name" value="LIPOPOLYSACCHARIDE 1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE95478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="492" mass="53188" checksum="F443CFB2FADC5955" modified="2015-04-29" version="1">MFNVKTARLALLVAVGVLIVIATTTGPIPPQKQPGAAPAAAALAGGAASGNSEPNLNPLSGDVPVGRREAPQPASGAANAAAAAAAAKKPHPPAASPAAVAAAAAAAASDKKDAAAEGVMGDAPPAPVDPNDPFLPQNRKLAPLESYKPLVDDGVMRINVMIASDANTLIGVIAVVKSILANTKTPDRIDFYLIVDTDQEAVRCQRWLNLAFEKKRQAQFWVKVFPLEWVANKIKIRGRRQDLASPANYARYYVLDLFPNLTGRIAYIDSDVVVQDDVAGLYFHPIEPGHIGAFVKDCHNELRFFINFEHPRVLAQQMDPSTCSFNAGVYVADLTEWKRQRMSKELEFWMELNTRENVYGGEGSGGGSQPPMLLALYGRATELNPLWHVRHLGWSGSYAYTAEFVKSAHLLHWNGAGKPWLLVPGVNFPSVWRQFCTPEPELSATACSEPSDGPSYKYVSDEAMLAEHCTQVREQRAADAEIGIALDCTFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUF8</accession>
    <name>A0A0D2WUF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345596.1">
        <property type="nucleotide sequence ID" value="XM_004345546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUF8"/>
    <dbReference type="STRING" id="595528.A0A0D2WUF8"/>
    <dbReference type="InParanoid" id="A0A0D2WUF8"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="31404" checksum="09C13D1EE1F366C1" modified="2015-04-29" version="1">MTSTLCQVCYEETFTSMSSCCGRACETCMWKMFTTTIKNTHAGYILLTCPACGDAVTDEVAGELLAYDVFERLQANRQTQLVKMEYVSCAWCNAEFDVTKAQTWADDMFVGVSRERPTDRRDCVMCPECKQDVCRGCGSRYEFHAGVSCTNYLTWAVENQGEWETSRAKNFDFYFSLRESNPYQAEMQGSIVSKQRDMRDSLHMIHGSTKPCPDCSIRIEKNGGCNHHTHHCHGATTASHFCWECLDRHADGTVIANGVRCAHGITRYWAQFAVARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUQ0</accession>
    <name>A0A0D2WUQ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUQ0"/>
    <dbReference type="FunCoup" id="A0A0D2WUQ0">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUQ0"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUQ0"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUQ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="110" mass="12475" checksum="0E7518805B58DF75" modified="2015-04-29" version="1">MTNLRFDRAAGGGPSTSAGSNDRLRQTQDQVDEVVGIMKNNVEKVLERDAKLTDIQDKSEALRDGAERFQTTSRKLKRKMWYKNIKFMIILVVVVLILIGAIVLWAAPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUQ8</accession>
    <name>A0A0D2WUQ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345753.2">
        <property type="nucleotide sequence ID" value="XM_004345703.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUQ8"/>
    <dbReference type="eggNOG" id="KOG1717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUQ8"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="912"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1400"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1446" mass="153091" checksum="955C58D23893D262" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVY1</accession>
    <name>A0A0D2WVY1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343408.1">
        <property type="nucleotide sequence ID" value="XM_004343358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVY1"/>
    <dbReference type="STRING" id="595528.A0A0D2WVY1"/>
    <dbReference type="eggNOG" id="KOG2138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVY1"/>
    <dbReference type="OMA" id="DQQKPDT"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1231" mass="131121" checksum="D5E81041AB32989A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW11</accession>
    <name>A0A0D2WW11_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344497.1">
        <property type="nucleotide sequence ID" value="XM_004344447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW11"/>
    <dbReference type="InParanoid" id="A0A0D2WW11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="112" mass="12415" checksum="E9352FBDF78C2EDA" modified="2015-04-29" version="1">MFRFTLSKLSQSHEIQMADIEKRIAQRLAVRIAKRRAKAQGVAIVIDFFGGCGVASALNEAQQLINDAQDVRAAARLTALLLTRDKAALKKQLQGLGEDQLDKWIDQQIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW30</accession>
    <name>A0A0D2WW30_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344524.1">
        <property type="nucleotide sequence ID" value="XM_004344474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW30"/>
    <dbReference type="FunCoup" id="A0A0D2WW30">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW30"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW30"/>
    <dbReference type="OMA" id="VKTGICD"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW30"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="347"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE96603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="678" mass="72443" checksum="504064C832B861AB" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW51</accession>
    <name>A0A0D2WW51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_007608</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW51"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW51"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="504"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="770"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="580"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE97150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2074" mass="230928" checksum="9EC51380158D063D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW96</accession>
    <name>A0A0D2WW96_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343550.2">
        <property type="nucleotide sequence ID" value="XM_004343500.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW96"/>
    <dbReference type="InParanoid" id="A0A0D2WW96"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW96"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="177" mass="19648" checksum="F09C6D62BCC07BAB" modified="2015-04-29" version="1">MERVNNGGALAIAEALRVNKTVTTLSLRNNFIGHAGVQSLRKAQTVNCRRSLTFDFQRDPLALSLLPRFETAENTQTVFNLLISGPEMKDQFATLPALPVEIAELIMDEASYWQGEQCAQHLSFYPRAFTVPRNVNGASIRVKTIQALRDRKIPPDVFDDQSGESSHHPTNARGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWB4</accession>
    <name>A0A0D2WWB4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Patatin-like phospholipase domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343759.2">
        <property type="nucleotide sequence ID" value="XM_004343709.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WWB4"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWB4"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWB4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="249"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="483"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="564"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE96763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1349" mass="147544" checksum="F62138C834095797" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX75</accession>
    <name>A0A0D2WX75_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342898.1">
        <property type="nucleotide sequence ID" value="XM_004342849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX75"/>
    <dbReference type="FunCoup" id="A0A0D2WX75">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WX75"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WX75"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX75"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000001">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="279"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="538" mass="61227" checksum="9D93C36E5E13E26D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY78</accession>
    <name>A0A0D2WY78_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_008323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346397">
        <property type="protein sequence ID" value="KJE98355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY78"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY78"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266665" description="LRRNT domain-containing protein" evidence="11">
        <location>
            <begin position="33"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE98355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="119727" checksum="0E0C4E793EC458E1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYA2</accession>
    <name>A0A0D2WYA2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346413">
        <property type="protein sequence ID" value="KJE98395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYA2"/>
    <dbReference type="InParanoid" id="A0A0D2WYA2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="62602" checksum="E6A06BA7D57E03E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0I4</accession>
    <name>A0A0D2X0I4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAF53b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365527.2">
        <property type="nucleotide sequence ID" value="XM_004365470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0I4"/>
    <dbReference type="FunCoup" id="A0A0D2X0I4">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0I4"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0I4"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0I4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="471" mass="50079" checksum="8260DFAC0D4DE346" modified="2015-04-29" version="1">MSGAMFGGDEVGALVLDIGSATTRFGFAGEDTPKSVFPSVVGLAPSHHAASQDSVPMDTSDRDLPSGTAGGAARRSRKSYVGTTTLAVVRSNVDLAGVMQNGLVEDWERFELLADYGFATGLRVDAAQHPLLMIEPSWNPRESREHMTELFFEKYNVPAFYLARSAVASAFANGRPTGLVLDIGASLSSAVPVVDGFVMPKSIMTSSVGGDFLLSQCAQYLEKNQIVIRPSYMVASKQAVALNAAPKWTPRTFAEPISDSFHRYSKQLVLQDFVHSVLFCSGRTFDRDSVANLPAASFEFPDGLNISLGADRYRLAETLFDPETHADATAPAVSVSSRASSASAMDATSDGTKDPAGGLAAPKPIGLHRLATAAINSCDVDVRPSIGSSVIVVGGGSLVRGLPERLDAELRMALPAISKLKTVASGLSVERMFSSWIGGSILASLGSFQQMWMSKQEYEESGKAYIEKKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0M7</accession>
    <name>A0A0D2X0M7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365695.1">
        <property type="nucleotide sequence ID" value="XM_004365638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0M7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0M7"/>
    <dbReference type="eggNOG" id="ENOG502QR1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0M7"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0M7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="426" mass="43958" checksum="56C2B2458FC9B127" modified="2015-04-29" version="1">MQPAAATLGKREAAVHARQRVLSHSQQLRGRGMEVDSLSAMTAVDHGRQVLDSVRRRRELRTQTYTQLVNDGTVAPVAPKRRRGAGLMHASASPGMGMGIGMGGGSGGGAAHMSMLDGGDLMLGALPRCPICDQVLRGDMDRINAHIDKCLGQPREAGNAAAAAAADTNANSGGAAMARLDALDAAAETSNGNAFDTYEWCGQTRVRATALLAQNQGALHILSSSAPPPPSSAASGAHPLHSGSGLYASTTGTGTEMDVNDQDEDEDLDVDQDDSAVYGTAQFTEHDLEMVNTAGTTATSMTDASGTTASAALSLPAPAGAPADSSSGTAAAVAVAAAGSEQASSASIVMQSLKEMIRDLQTQLASSTVAAHKCLICMEPYTNPAVSINCWHVHCQQCWLATLGAKKVCPQCNIITTPAHLRRIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U7</accession>
    <name>A0A0D2X0U7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365984.1">
        <property type="nucleotide sequence ID" value="XM_004365927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0U7"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0U7"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="363" mass="39931" checksum="E1ED65CB02BD9CD3" modified="2015-04-29" version="1">MSKPSILVLGGVGFIGRNLIVHLVENSLASKIRVVDKVLPQTAWLTERQTKAFAGVEFVQGNLTNAASTANAFDNAGASFDFVINLAAETKYGQTEKIYEEKVLSLSVCVAKEAAKRGVKRFIEVSTAQVYSSDKDASTETDKLNPWTTIAQYKLKAEEAIKGIAGLNYVIVRPAIVYGTGDLLGLTPRLIIGAVYKSLNEQMKLLWTEKLRLNTVHVDDVARALFYLTDHGNSGEIYNLADKGDTSQDTVSTILDQIFGIKHSYAGSIQSNLAKLNMKNITEDVNESHMDPWSKLLKADGIENTPLSPYLDQELLYNNNTTVDGSKIEKLGFSYTQPQLTKDALKNVVDEYVKLGLFPKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1E9</accession>
    <name>A0A0D2X1E9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1E9"/>
    <dbReference type="STRING" id="595528.A0A0D2X1E9"/>
    <dbReference type="InParanoid" id="A0A0D2X1E9"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1E9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="147" mass="16424" checksum="3DDA1683D2ACCCD1" modified="2015-04-29" version="1">MLRHDVQVAKQPRRGTRTEHERDVSAWATARLKAVLAALKHEDERVKIRVASVTTVEGEANIVFPRGKKRAGYEFAAKVKVEVTPAGASSAATGTLEFPYICDDVSNHAYEIKLVFADKAAQALLDDYRSVFLDAVRTQFYDELMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Y4</accession>
    <name>A0A0D2X1Y4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fanconi anemia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_002730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349480.1">
        <property type="nucleotide sequence ID" value="XM_004349430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Y4"/>
    <dbReference type="STRING" id="595528.A0A0D2X1Y4"/>
    <dbReference type="eggNOG" id="KOG3268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Y4"/>
    <dbReference type="OMA" id="NRPFHAK"/>
    <dbReference type="OrthoDB" id="10263265at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Y4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23831">
        <property type="entry name" value="DRWD-N_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23786">
        <property type="entry name" value="ELF_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16490">
        <property type="entry name" value="RING-CH-C4HC3_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026850">
        <property type="entry name" value="FANCL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019162">
        <property type="entry name" value="FancL_WD-rpt_cont_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11793">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09765">
        <property type="entry name" value="FANCL_d1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anemia complex subunit FancL WD-repeat containing" evidence="1">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="3">
        <location>
            <begin position="145"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="4">
        <location>
            <begin position="236"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL C-terminal" evidence="2">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE91614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="411" mass="45594" checksum="E186FCEC9B53EA9F" modified="2015-04-29" version="1">MATDNRSQLHCAPALALAAFPTLLPEYSAPTHEAFAIALAGGSTTDLGQALSAYSGIVSIKGREFRLRLELSASTRLADAVVEGCPALVQLLSGCEDVVAQRIKQSVDLNAFSFELRDLLERLVDAADRPAATGYVLQQGLRSSEFYTRVIEELDAVGWHNVSLEDDTLSNIRFTARDDRQREHSLIVQPHPQHPAVPPTCVAALPEPFRILRWNSASSLSNVFQQFQQALQRFQQLWDDLDEIDANTWVLEPERPTRDCCHRRMALEHNSSVQILVNPKAVRAVPECRFLGADSIVNPLRDAMNDNISQWDETKPLLANLGIVLNVQFPSPATVSREEVTVACGICYSYDLGDSVPDKVCDGPKCRQPFHQACLIEWLRGLPSFQQSFNTIFGECPNCSKPMAIKLMPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X279</accession>
    <name>A0A0D2X279_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363955.2">
        <property type="nucleotide sequence ID" value="XM_004363898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X279"/>
    <dbReference type="InParanoid" id="A0A0D2X279"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X279"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="70"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="296" mass="32631" checksum="D8EEB03C785799FC" modified="2015-04-29" version="1">MMSKTAPHPFARAVAIWNTAPTGGPGAAKAAAASPAERTAVFQRVISFYSHTRREEDGAREDAELGINRLCFSNLFPCTIHVSAHVERTAAAAAGVSQLLIHKELVDIDYSSTENLFQAAKCANLCDALFVAHALDSREAAMFGQGRMTLSDAHRERLIKYGANPDDFQRAKSNSWKRTASGYPLMREDWDSIKPYVMMTALRLKFDVPSVGAAIVQTGAQEAVNSLTALAARDENILLVEHVDRDRQWGDGLLGEGTNMLGKMLTQLLWEKRHGCTYPLDLAWLRRPNNTVAEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X295</accession>
    <name>A0A0D2X295_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364026.1">
        <property type="nucleotide sequence ID" value="XM_004363969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X295"/>
    <dbReference type="STRING" id="595528.A0A0D2X295"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X295"/>
    <dbReference type="OMA" id="YNGADVW"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X295"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="131" mass="14240" checksum="60167F0AB0E4FABA" modified="2015-04-29" version="1">MTEVFKALRDGKEADALKLITKLASKKKTLTFADDHGWTPLHFAANSGFGEIVTLLSKNGASVQAKNNQGQTPLMLAAAKGHIDVCRKLVEAGSELLVTDNNGWSPKVTASKFDHKAIVTFLEGEERFAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2G1</accession>
    <name>A0A0D2X2G1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364294.1">
        <property type="nucleotide sequence ID" value="XM_004364237.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2G1"/>
    <dbReference type="eggNOG" id="KOG0818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2G1"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01783">
        <property type="entry name" value="RA2_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057346">
        <property type="entry name" value="Talin1/2_VBS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25177">
        <property type="entry name" value="Talin_VBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="389"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="490"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="591"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="707"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1466"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1309"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1413"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1640" mass="177768" checksum="99FDAD1D32826B1D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3K0</accession>
    <name>A0A0D2X3K0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3K0"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3K0"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3K0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="46959" checksum="CA40DDF3D4CDBC33" modified="2015-04-29" version="1">MEERLPEEEIGDAGAKAIAEALKVNATVTTLDLGKNQIGDAGARTIAETLKVNTTLTQLFLYRNQIREGGMNAIAEALKVNTSVTALGLGINQIGDAGAQAIAETLKVNTTVTRLYLDQNQIGEAGAQAIAETLKVNKTLSELYLGDNRISDAGATPIAEALKVNTTLTALDLGKNQIGNLGMMAIAEALKVNTSLTEHNLNVNQIGDEGAKAIAEALKVNTSVKKLNLAFNCIGKVAAQAIQDARPLTELKLNYQINPLAFALRPRLATAEDLQIVFRMLTSGLELENQSASLPALPAEIADLIMDEAYYWQGVERVNWIEGTADGVLKVTVPQSINGNSIRVKVIQVLWDKSTEGKSKQNCVFYLTIRDEQGVVRYECAATPSFVDSTIRLATIWPASHPVIRQMREGWEVQVQPSEPPGDDVLEYLYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3Y1</accession>
    <name>A0A0D2X3Y1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346262.2">
        <property type="nucleotide sequence ID" value="XM_004346212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3Y1"/>
    <dbReference type="InParanoid" id="A0A0D2X3Y1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="954"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1269" mass="134993" checksum="4B5DBA717F026D52" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X473</accession>
    <name>A0A0D2X473_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_006002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345592.1">
        <property type="nucleotide sequence ID" value="XM_004345542.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X473"/>
    <dbReference type="InParanoid" id="A0A0D2X473"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254871" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132335" checksum="549B9621B80228A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A1</accession>
    <name>A0A0D2X4A1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345713.1">
        <property type="nucleotide sequence ID" value="XM_004345663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4A1"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4A1"/>
    <dbReference type="OMA" id="HFNLPWH"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="31818" checksum="8750A395C315F51C" modified="2015-04-29" version="1">MSSSHFVVGGVPEHFNAPFHLGMKDGTFARHGVTLDFVDCLGGTGEMTTKLNNGELDVAVALTEGLIAAIAKGEARFKLAAEYCRSPLIWAVSTGANSEVKSVADLDGKTFGISRFGSGSHIMAIVLAKNNGFVQDNHWRVLRNFQGLRDGVNTSEADAFLWEKFTTKPFHDTREVVKVGEIVTPWPAFMVAVSDAALQREGATEKLAALFRGIQESCANFARNDDGASVQYVADKYGNTLDDAAKWFSAVEFSQDGALSSAVLTNVVSILKEADVLTADIHAPPQALVAPALARII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4L2</accession>
    <name>A0A0D2X4L2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4L2"/>
    <dbReference type="STRING" id="595528.A0A0D2X4L2"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4L2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4L2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266816" evidence="10">
        <location>
            <begin position="42"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="652"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="941" mass="98387" checksum="E9AC0557FED18363" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X505</accession>
    <name>A0A0D2X505_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X505"/>
    <dbReference type="STRING" id="595528.A0A0D2X505"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X505"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X505"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="6">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE96969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="137" mass="14378" checksum="5AE85122167779E8" modified="2015-04-29" version="1" fragment="single">HCNPTFYRPCLTPIVSGVCGGVDLTYGCQACNCNHHAAIVVGGGETCNEVGGICDCAPSSHTTGNRCERCEENYQNPFGTGVYGSCFPCNCWTHSETCSAIGTCTNCRDNTTGSHRCASCQNGFFGNPSEGIPCTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X512</accession>
    <name>A0A0D2X512_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Differentially expressed in FDCP 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_007492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343366.1">
        <property type="nucleotide sequence ID" value="XM_004343316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X512"/>
    <dbReference type="STRING" id="595528.A0A0D2X512"/>
    <dbReference type="eggNOG" id="KOG1829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X512"/>
    <dbReference type="OMA" id="IWRDYYC"/>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X512"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17671">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF12">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RUN DOMAIN CONTAINING M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="12">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="663"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="969" mass="106565" checksum="01DAF8B84FA4B17A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X587</accession>
    <name>A0A0D2X587_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NEDD8 carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343109.1">
        <property type="nucleotide sequence ID" value="XM_004343059.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X587"/>
    <dbReference type="FunCoup" id="A0A0D2X587">
        <property type="interactions" value="763"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X587"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X587"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X587"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="183" mass="20580" checksum="BF5655626C36CE89" modified="2015-04-29" version="1">MINLFSLKQQKKDAAAAGGKKTSAAQLRTQKDINDLNLPSTCKVDFPNPDDLLTFNLAIAPDEGFYKGGLFRFTFKIGPNYPHEPPKVHCEQKIYHPNIDLQGNVCLNILREDWKPVLSINSVIYGLQFLFLEPNPDDPLNKEAAANLRENRRGFEANVTRSLRGGSVENNVFDNCMRSGNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5N7</accession>
    <name>A0A0D2X5N7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342744.1">
        <property type="nucleotide sequence ID" value="XM_004342695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5N7"/>
    <dbReference type="eggNOG" id="ENOG502SZTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5N7"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5N7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="634" mass="71078" checksum="1A63F07A494EF471" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5R1</accession>
    <name>A0A0D2X5R1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">TKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_009189</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270906.1">
        <property type="nucleotide sequence ID" value="XM_011272604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5R1"/>
    <dbReference type="STRING" id="595528.A0A0D2X5R1"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5R1"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5R1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="276"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE98249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="565" mass="60014" checksum="0C774E23E2CEDBF3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9CDF3</accession>
    <name>E9CDF3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345733.2">
        <property type="nucleotide sequence ID" value="XM_004345683.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270588.1">
        <property type="nucleotide sequence ID" value="XM_011272286.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.E9CDF3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CDF3"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="922"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1526" mass="163599" checksum="9E6B050812EE1FAC" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9CH47</accession>
    <accession>E9CH68</accession>
    <name>E9CH47_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007501</name>
        <name evidence="11" type="ORF">CAOG_007522</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343375.2">
        <property type="nucleotide sequence ID" value="XM_004343325.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343396.1">
        <property type="nucleotide sequence ID" value="XM_004343346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9CH47"/>
    <dbReference type="FunCoup" id="E9CH47">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="595528.E9CH47"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9CH47"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="338" mass="36185" checksum="AE572501A888056C" modified="2013-09-18" version="2">MSNDTNECSFESVDDYDQRYNIAAIFIILVTSMMGTLLPILAKRNPTWICFRSPFVFTIGKHVGTGVIIALALIHLLTPAYEALGNPCLPAAFAEDYTFAPLFAMLGALVMHLFETLASMRDLKTALKSETSQPGMVQVSASDSDPERGQNSSCTATATPDSLLFAHGHSHGGLLGNSSAERTIGAYVLEFGLTAHSVIIGLTVGVSSVTDLETLIPALVFHQFFEGIALGARLVECNFSKLNEFLLAFIYSVSAPVGIAIGIGIVNSYNENGVTTNLVQGTFDAVSAGILLYVGFTQMLAIEFPRDFAAASSRARRVALFVAMWVGAGIMAFIGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0J5</accession>
    <name>A0A0D2U0J5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365222.2">
        <property type="nucleotide sequence ID" value="XM_004365165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0J5"/>
    <dbReference type="STRING" id="595528.A0A0D2U0J5"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U0J5"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF57">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="657"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="96824" checksum="E6242DE325AFCCEF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2U9</accession>
    <name>A0A0D2U2U9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vigilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365834.1">
        <property type="nucleotide sequence ID" value="XM_004365777.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2U2U9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U2U9"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U2U9"/>
    <dbReference type="OMA" id="DHAGQQV"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U2U9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22413">
        <property type="entry name" value="KH-I_Vigilin_rpt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22409">
        <property type="entry name" value="KH-I_Vigilin_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22411">
        <property type="entry name" value="KH-I_Vigilin_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="229"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="303"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="443"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="515"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="589"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="661"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="738"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="811"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="897"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1306" mass="141525" checksum="849C73C7BBF4B8D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6S3</accession>
    <name>A0A0D2U6S3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348859.1">
        <property type="nucleotide sequence ID" value="XM_004348809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6S3"/>
    <dbReference type="STRING" id="595528.A0A0D2U6S3"/>
    <dbReference type="eggNOG" id="ENOG502RYGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U6S3"/>
    <dbReference type="OMA" id="YQVIQMN"/>
    <dbReference type="OrthoDB" id="343907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U6S3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="130" mass="13936" checksum="7661FA2EE78F7CC5" modified="2015-04-29" version="1">MAEALQGFFDRLLTRVPGLLAAIVTDRDGVIVVKATTSANPQATLQAGYLASFTAAIEQASKIGLQKNTVVACSYESYQTVHFNHLPIILTFIASSEANIGVLLSLEDELAKVIEPIASNFRSRAAELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7I3</accession>
    <name>A0A0D2U7I3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7I3"/>
    <dbReference type="STRING" id="595528.A0A0D2U7I3"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7I3"/>
    <dbReference type="OMA" id="ESMWVAT"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7I3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268356" description="Coiled-coil domain-containing protein 47" evidence="6">
        <location>
            <begin position="21"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52098" checksum="640BC2CC1D6FB052" modified="2015-04-29" version="1">MRAATLVAVLVVIALASISAVPASLSNNHHGSITTTTTTTLFGSQSNTLSVQQLHPALAAAAGPVLFASAQEEDSFGDEEDEVVATDDDGDDEEVEVVVPAKSAKSKTTTATTTTTTTTGDDDEEAVEQEVETAPAGESDAEAKPRKAKKAPKVAPVPRVQKVRGLPEFTFSNWYPELFSLLGMVVYVLNYFTGRSKNTTLATAWARENGAILQKNFAQTTDPESRAMLYPENASMFYNWSTGRVNCAGMLTTLDFLRRPDLLSMVFATTLQPATDKITYAVEMNNDAMDTFVVAFGPKAKLTKLRSEMHDLSFFTTGYSGESYGLPASFAVHTDCPEVARELITPELAERIRANPKTFDVFHFSDKFQGTIDNEVPADQRPTPRPMLFMTFNLSKQRADKKRAQMQDELNKIAHQKLQEAAQLKREEKLRLERQQAMNSSDPDARAKWEEKQRKDEMKKRMAKGKIAVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9H6</accession>
    <name>A0A0D2U9H6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9H6"/>
    <dbReference type="STRING" id="595528.A0A0D2U9H6"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U9H6"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U9H6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="3">
        <location>
            <begin position="303"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="664" mass="72101" checksum="830FAE80BFED6C3E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UG25</accession>
    <name>A0A0D2UG25_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_004743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UG25"/>
    <dbReference type="STRING" id="595528.A0A0D2UG25"/>
    <dbReference type="eggNOG" id="KOG3800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UG25"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UG25"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAT1 centre" evidence="2">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MAT1 C-terminal CAK anchor" evidence="3">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="213" mass="24311" checksum="DE6140F1C5DCC783" modified="2015-04-29" version="1">MDERDVNDFCPFCKTDVYFLQNAEMLVTPCGHKLQHFTQLTMPCLVCKRLVKRTELARQTFQDLGVDREVKIRRNVMKVFTKSESAFASLDEYNNYLEEIEDIVFNLASNDDNDVREATERLNKYKQAHTAEIEAAANAAASAQAQRYRQARFVYQAPPRNNNGPRIPTLSEVTSLQYTQLVQEKDVSKAAGFSTAYPARRALCEAFSSLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGF9</accession>
    <name>A0A0D2UGF9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Inositol 1,4,5-triphosphate receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAOG_004826</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347577.1">
        <property type="nucleotide sequence ID" value="XM_004347527.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UGF9"/>
    <dbReference type="eggNOG" id="KOG3533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UGF9"/>
    <dbReference type="OMA" id="WFGFMQS"/>
    <dbReference type="OrthoDB" id="76898at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UGF9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23277">
        <property type="entry name" value="beta-trefoil_MIR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000002">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000005">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000024">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000001">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor, type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816">
        <property type="entry name" value="MIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816:SF4">
        <property type="entry name" value="RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2639"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2742"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2791"/>
            <end position="2820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2841"/>
            <end position="2863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2925"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="965"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1052"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1237"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1500"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1587"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1634"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3074"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3202"/>
            <end position="3232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="2115"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1052"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1260"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1308"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1531"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1587"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1634"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1680"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="3074"/>
            <end position="3095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="3111"/>
            <end position="3124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJE94141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="3232" mass="351928" checksum="58F9C77955EBD0AD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHJ2</accession>
    <name>A0A0D2UHJ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystic fibrosis transmembrane conductance regulator</fullName>
            <ecNumber evidence="7">5.6.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">ATP-binding cassette sub-family C member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Channel conductance-controlling ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">cAMP-dependent chloride channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">CAOG_005195</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="37">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.</text>
            <dbReference type="EC" id="5.6.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>hydrogencarbonate(in) = hydrogencarbonate(out)</text>
            <dbReference type="Rhea" id="RHEA:28695"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.6" evidence="7"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346880.2">
        <property type="nucleotide sequence ID" value="XM_004346830.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHJ2"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHJ2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHJ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005260">
        <property type="term" value="F:intracellularly ATP-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18594">
        <property type="entry name" value="ABC_6TM_CFTR_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009147">
        <property type="entry name" value="CFTR/ABCC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01851">
        <property type="entry name" value="CYSFIBREGLTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 36" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0868">Chloride</keyword>
    <keyword evidence="20" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="24" id="KW-0407">Ion channel</keyword>
    <keyword evidence="18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="19 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1169"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1238"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1265"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1356"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="35">
        <location>
            <begin position="371"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="34">
        <location>
            <begin position="834"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="35">
        <location>
            <begin position="1132"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="34">
        <location>
            <begin position="1444"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="790"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00029720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00031358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00033163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00034073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KJE94566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1707" mass="186640" checksum="9944F3BFB963E4E6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UK11</accession>
    <name>A0A0D2UK11_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UK11"/>
    <dbReference type="InParanoid" id="A0A0D2UK11"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47263" checksum="3F3FD9753E4A172A" modified="2015-04-29" version="1">MLLSLLHDGHAAAAKDLELVPAPSRTRRTNSSSLGSSSPSCQFSEQQKEAIKQRWRARALHVVEKLTGAQAAQAFAPNLTDDAFEQWFANKMTKRAGHHHRRRNCFGGRFGGRFWHHHHQQQQQQQQQQQQDQTQAQAQAQSCFTPSAFDSHCAATPSSSSAPAECADANCAQSSEVYACASAPSCTDASACIVDEGPAAAAAAAVKPARARPVRIQFLVEGALVHDNANAAQQLFRNVTAIIREQGAGDTPNKKDSVGISVFGDDQLVDVLPMTRINKVNWEQTMAVGTKAAIPCATSNLGDAIKLQLELTAQEIYENPKWARATQFLVVVASGEDHTSDAPINDVSLLLSAHVAQYNTNLAVVGVGLTPSTQGYIDALTKDAMTVKPVQMLPCASANIAPVIPPLVASIAQQRAASAQARATHRSTKREERRAGHMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKX0</accession>
    <name>A0A0D2UKX0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 23">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6 23">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20 23">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAOG_006153</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6 23"/>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345743.2">
        <property type="nucleotide sequence ID" value="XM_004345693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKX0"/>
    <dbReference type="FunCoup" id="A0A0D2UKX0">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UKX0"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UKX0"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKX0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000029">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="18 25" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="24">
        <location>
            <begin position="197"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJE95731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="549" mass="61241" checksum="2A723AD80DA9DAE4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMT1</accession>
    <name>A0A0D2UMT1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344307.1">
        <property type="nucleotide sequence ID" value="XM_004344257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMT1"/>
    <dbReference type="STRING" id="595528.A0A0D2UMT1"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UMT1"/>
    <dbReference type="OMA" id="ECETIWG"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UMT1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="5">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="274" mass="30352" checksum="96E1932B5740B15F" modified="2015-04-29" version="1">MSIAQLLDAAENGDIDRVVRLIDEEGIDVNGQDEYMEWTPLILACNYGHLDVVELLLAKGADLYKSNYKRATPFHRACRGQHAHVVEYLLSIGVDFNRPDYQESPPIIYASSPHNDNTEVVALLVAAGADVMARNQFGRFPLLYVSSRGHPDSITVLLDANADINGTDNWGWTPLHEACRWNRVGCVQVLLDRGADVTMLTWDNGDTALELARRHGHESVIEEFRQRGSLLQTAEAAQVSDAAQERRAQIQRARDEASASATTGVNTSERAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UN86</accession>
    <name>A0A0D2UN86_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344424.2">
        <property type="nucleotide sequence ID" value="XM_004344374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UN86"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UN86"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UN86"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41709" checksum="FA8F27FF01025E7B" modified="2015-04-29" version="1">MLSAVQQTRSTTSLMLRQAVRTMTTHKPYLDAVRRPQPIAITPDPVDPLNNVPPLDQLPPGSTYMGLYVVLPGLARTRLRKCPIVQTPAFFDRLKREREQVRELRSDPERELRARTGQEIVPFDQPLTQTTWANSISRQLTLTFGIHNRIWTDLAEKVPKLTRYLKVTYPETAIVHGNLVPAGLTSSAPTVTFEPESGKYYTLMMVGLDSNISSANHQYMHWLVADISEAGISSGNTIYPYVQALPLKDTGYHRVAFLLLEHAAPLGMQAESIYNRIDLYARSFSTALFVNEFGVRIVGASFCQTFHDDSVEKAFARENVQLPVVKVTYTPDTSHGKHTRLPHVGPLVPIKDASMRKFDQRTERRLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPJ7</accession>
    <name>A0A0D2UPJ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golvesin/Xly CBD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270739.1">
        <property type="nucleotide sequence ID" value="XM_011272437.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPJ7"/>
    <dbReference type="InParanoid" id="A0A0D2UPJ7"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPJ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.40">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033803">
        <property type="entry name" value="CBD-like_Golvesin-Xly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25275">
        <property type="entry name" value="Golvesin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252983" description="Golvesin/Xly CBD-like domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="Golvesin/Xly CBD-like" evidence="4">
        <location>
            <begin position="123"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1548" mass="159193" checksum="8568B40E99ECEA12" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT91</accession>
    <name>A0A0D2UT91_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270887.1">
        <property type="nucleotide sequence ID" value="XM_011272585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT91"/>
    <dbReference type="InParanoid" id="A0A0D2UT91"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="289" mass="31279" checksum="1F089038E53D74EC" modified="2015-04-29" version="1">MGKPPALSVIATPAVEPAAAAPPPTAPQRRPPSEEDAPPPSPRQLPHSNSFSFDAHQQDDDDDDDNDSDDNHQTARSNNNNNNNKNSNNNSRSPPPLSLGGGNSAIHNSSNLSKSSSSSSSSSSSSSSGEGDSANKEDPGTPPDSPGGVRARRALPRLQLNKSNERQDTGVPAEFREKVLNLRDAVAAQFASLNGRLTASEFSQVARDFNKHMMALAEQRRDVRNLKSCNGINCEHDCAGEAQDLTHNSVLLYKFYQEKESRSEDFTQVDFHLKAFVDDVLYALLIESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFR9</accession>
    <name>A0A0D2VFR9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000218</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365089.1">
        <property type="nucleotide sequence ID" value="XM_004365032.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VFR9"/>
    <dbReference type="eggNOG" id="KOG0606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFR9"/>
    <dbReference type="OMA" id="CICTRTS"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000604">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="1735"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1604"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1767"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1612"/>
            <end position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1828" mass="191380" checksum="D1A899AED638871A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGG3</accession>
    <name>A0A0D2VGG3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_000529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365400.1">
        <property type="nucleotide sequence ID" value="XM_004365343.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGG3"/>
    <dbReference type="eggNOG" id="KOG4833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGG3"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGG3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="165"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2118"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2538"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2132"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2538"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2574"/>
            <end position="2583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2831" mass="301637" checksum="45D71BCA30C69EFE" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGU2</accession>
    <name>A0A0D2VGU2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_008431</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270002.1">
        <property type="nucleotide sequence ID" value="XM_011271700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGU2"/>
    <dbReference type="STRING" id="595528.A0A0D2VGU2"/>
    <dbReference type="InParanoid" id="A0A0D2VGU2"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="115"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="492"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="748"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112332" checksum="FED8FDC626D5CBC7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI94</accession>
    <name>A0A0D2VI94_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI94"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI94"/>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20389">
        <property type="entry name" value="Tudor_ARID4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20390">
        <property type="entry name" value="Tudor_ARID4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="439"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="455"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1358" mass="144218" checksum="DEEAD9DDC1AB0B8D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJE0</accession>
    <name>A0A0D2VJE0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Inositol 5-phosphatase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJE0"/>
    <dbReference type="STRING" id="595528.A0A0D2VJE0"/>
    <dbReference type="InParanoid" id="A0A0D2VJE0"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJE0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="694"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="914" mass="103929" checksum="C67A890B6136D91F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK08</accession>
    <name>A0A0D2VK08_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK08"/>
    <dbReference type="InParanoid" id="A0A0D2VK08"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="193" mass="21919" checksum="96D7622C8E118DF0" modified="2015-04-29" version="1">MQRQASPHTQPTSPTKHKRGDSVRRIRNRGISGSHYLCNEALSADLLSFCVWTHFRNLARPSLHAPRSREASVALQDCIADWLGCTVRAQRETERQRARERESEGVLWRERVIAGSSSFHRFAVSPGPTRSIEEASHGSREQRKRTYSHTQRARERESARSRESMDLKRVSHCQPLPACLASPPLCSPPEEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK83</accession>
    <name>A0A0D2VK83_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK83"/>
    <dbReference type="InParanoid" id="A0A0D2VK83"/>
    <dbReference type="OrthoDB" id="2429079at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK83"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="461" mass="51751" checksum="EF477BAC2D5A88DA" modified="2015-04-29" version="1">MASMPRIGKTRASLEYLKHAVQMTRASGHDTRVVPIYVTYNRCTHFGVWDRALGADLSIAYRVLLEYASGNMSWPRDVVGNIAAAIGKVSLEDALDIIAMHAMQHKPNLDQLQCPGDPSSSTSPSLPALNSSNPPKVMFVLILDEFQRALINKGTTPEPRDPANKISSPFLQSVVTAMGSCAVRDASSRIWHSTTLFTGLSYGPLQELFRLLSHPLKRFAVPCLTFAQSVTWVKAFLSVKRPKSWPPGDDITKDSVFQRMLIYASGHARCIEFICDALDSEKFVASLRPHSLELPFMEKIEWVLQYRCNTLTDEQIEAILVAALRPVGFDKQENADSVRNLIEVNGLGTMIDSQLILPMHIARVLIWRLHYLNRHQAVPSTLKRLWRMLDTLLDNSRPHAPFFLSLETACATALSLRLYSFALEYPHHTVWTLETLHRGARFNANSSIAGLKIKEAQRQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VK99</accession>
    <name>A0A0D2VK99_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364621.1">
        <property type="nucleotide sequence ID" value="XM_004364564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VK99"/>
    <dbReference type="STRING" id="595528.A0A0D2VK99"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VK99"/>
    <dbReference type="OMA" id="CDIRGVF"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VK99"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="103"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="422" mass="43035" checksum="C35E180B1B5C0848" modified="2015-04-29" version="1">MSSAVGHHEALLRPLLRSVATLTATTNAAMVAAKGSSLAPSSALSASFSTCAASSGVVSSAPAASSSSSSSASSSSSSSSSKPNKPSSIVRAAVCSELKAPLTLSADYSPAGHPLVAKISPEKRVRIGIRACGVNFADTLMVEGLYQVKPPLPFVPGAEIAGIVLETGSAVKSVKIGDHVIALLDGGGFATECIAHEAQVYALPKTIAFGQAAALPVSYGTAITALSYRAQTKPGETVLITAAAGGVGLASIELAKRVLGAKVIACAGGAEKLAVCQAKGADHVIDYNKESIKDRVKEITNGKGVNVVIEVVGGDTFDQCLRSLAPEGRLVVIGFASGSIPSIPANLTLVKNIAVLGLYWGGYQAFNPSVLRNSIKDVIKHCEAGHISPVVSATYPLDQVNDAFALLRTRKSTGKVVVTMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMF6</accession>
    <name>A0A0D2VMF6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_002491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMF6"/>
    <dbReference type="STRING" id="595528.A0A0D2VMF6"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMF6"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMF6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="327"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE91342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="526" mass="56148" checksum="BA480155AF08114F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMN2</accession>
    <name>A0A0D2VMN2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_002575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMN2"/>
    <dbReference type="FunCoup" id="A0A0D2VMN2">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMN2"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMN2"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="230"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="463"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="616" mass="68208" checksum="8048FCEDF9A79784" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNN0</accession>
    <name>A0A0D2VNN0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363833.1">
        <property type="nucleotide sequence ID" value="XM_004363776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNN0"/>
    <dbReference type="STRING" id="595528.A0A0D2VNN0"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNN0"/>
    <dbReference type="OMA" id="CANFMTK"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNN0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CHY-type" evidence="8">
        <location>
            <begin position="857"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="941"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="103975" checksum="1B83E65D51F276BD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ13</accession>
    <name>A0A0D2VQ13_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348441.2">
        <property type="nucleotide sequence ID" value="XM_004348391.2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ13"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1714" mass="180447" checksum="85F5987DC50911B4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ63</accession>
    <name>A0A0D2VQ63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_003637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363365.1">
        <property type="nucleotide sequence ID" value="XM_004363308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ63"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ63"/>
    <dbReference type="InParanoid" id="A0A0D2VQ63"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="11">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="794"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE92722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="113929" checksum="0B62649582962D02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTH9</accession>
    <name>A0A0D2VTH9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346875.1">
        <property type="nucleotide sequence ID" value="XM_004346825.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTH9"/>
    <dbReference type="InParanoid" id="A0A0D2VTH9"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="156" mass="17107" checksum="FD26CA4BD147FF0D" modified="2015-04-29" version="1">MANKGILILSALATAGWITFCIGFGFRNDWDADEIKESFNPTLFCWWTFALAGLVGTAALIFYGVNRSAGLGAAALFVNLLMMVCAGAVTNTNGQIIYSCLSNNDDQSSCITSQSSVADYNKVEFSGSFIYLLFQGITICYWFYSAHEYHSYNMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUV2</accession>
    <name>A0A0D2VUV2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346311.2">
        <property type="nucleotide sequence ID" value="XM_004346261.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUV2"/>
    <dbReference type="FunCoup" id="A0A0D2VUV2">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VUV2"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VUV2"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VUV2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="3">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="740" mass="81829" checksum="241DA088C6C29943" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY74</accession>
    <name>A0A0D2VY74_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Stearoyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAOG_006931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344552.1">
        <property type="nucleotide sequence ID" value="XM_004344502.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY74"/>
    <dbReference type="FunCoup" id="A0A0D2VY74">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VY74"/>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VY74"/>
    <dbReference type="OMA" id="WNDWRGG"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VY74"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="353"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJE96632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="49341" checksum="D9D1E1ADD156CFD5" modified="2015-04-29" version="1">MPPFVREAAVVAGGASAEPFALEADRMLSSVPSNDQRYLPGKGMRPRTEPLPAAQFDWIVGSVLLITPFIAIWGIINVPLQTPTLIYTVLLYFASGLGITAGYHRLWSHKAYDAAWPLELFLALSGAAAMEGSGRWWCRNHRAHHKFTDTPKDPYNVRRSLLWAHIGWMLVKQNKNEVGYADITDLDENKILQWQHRNYPLLVLLCGVAVPWLTAGLLWGDWWGGYFYCVILRLVFIHHSTFFVNSLAHYLGNQPYSDMHTAFDSFITAVLSLGEGYHNYHHEFPQDYRNGIKWYHYDPTKWFIVACSYVGLAYNLKFIPKNEIDKAKLQMSQNALDEHKALLEFGKTLSKDLPVFTRQQVRTEAASGRSLVIVSNRVYDASKFVDVHPGGRQTLLKHVGEDVTPLFRGDTGEHIHSKFAIATLKRMLVGQVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZC0</accession>
    <name>A0A0D2VZC0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twin-arginine translocation pathway signal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343486.2">
        <property type="nucleotide sequence ID" value="XM_004343436.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZC0"/>
    <dbReference type="STRING" id="595528.A0A0D2VZC0"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZC0"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269631" evidence="2">
        <location>
            <begin position="29"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="522" mass="56503" checksum="F26CCE06F515ACC4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZW6</accession>
    <name>A0A0D2VZW6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_009069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270802.1">
        <property type="nucleotide sequence ID" value="XM_011272500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZW6"/>
    <dbReference type="STRING" id="595528.A0A0D2VZW6"/>
    <dbReference type="eggNOG" id="KOG3774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZW6"/>
    <dbReference type="OMA" id="LQIYYHY"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZW6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF1">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011330338" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="547" mass="60574" checksum="F75E761105CE8FC8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZZ9</accession>
    <name>A0A0D2VZZ9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAOG_007322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343181.1">
        <property type="nucleotide sequence ID" value="XM_004343131.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZZ9"/>
    <dbReference type="FunCoup" id="A0A0D2VZZ9">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VZZ9"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VZZ9"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VZZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 15 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJE97467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="18336" checksum="220FC867152733F7" modified="2015-04-29" version="1">MEQTEKAFQKQPTIFGAKKRVLVQKISQREGRFWRNVGLGIKTPREAIEGNYVDKKCPFTGDVSIRGRILTGVIANNKMKRTITVRRDYLHYIKKYNRFEKRHRNLSAHISPAFKDVDVGDSVVVGQCRPLSKTVRFNVLKVIKDLKAEKAKKQFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1S1</accession>
    <name>A0A0D2W1S1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_009193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346378">
        <property type="protein sequence ID" value="KJE98287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270910.1">
        <property type="nucleotide sequence ID" value="XM_011272608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1S1"/>
    <dbReference type="InParanoid" id="A0A0D2W1S1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE98287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="149" mass="15725" checksum="50B41F8E67D21504" modified="2015-04-29" version="1">MQFAHASRGASVADRVVDLVMNDLLYIKNWRDVQRYHHSGLDLPYALGRPAADAPLSPVVALHAAAPVSIDYVVQLFRGLGSGGCAAAAGAQSGSTNAPAIVATESAASSSKIYIAFVDADASIAYYVFSAGLETSVTDEHRWMRLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGT1</accession>
    <name>A0A0D2WGT1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGT1"/>
    <dbReference type="eggNOG" id="ENOG502QSW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGT1"/>
    <dbReference type="OrthoDB" id="62987at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGT1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17481">
        <property type="entry name" value="MFS_MFSD13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="615" mass="65699" checksum="EB9BC36F5E7DFFB1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI63</accession>
    <name>A0A0D2WI63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365828.1">
        <property type="nucleotide sequence ID" value="XM_004365771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI63"/>
    <dbReference type="FunCoup" id="A0A0D2WI63">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WI63"/>
    <dbReference type="eggNOG" id="KOG3174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI63"/>
    <dbReference type="OMA" id="WSNKYYP"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="272" mass="30122" checksum="8C7C41D8CBC5DFCC" modified="2015-04-29" version="1">MSEQQLDCALDLMRRLPPQNIEENLAGLIDLAPSLCEDLLSSIDQPLKIAKDKESGRDYLLCDYNRDGDSYRSPWSNKYDPPISDGTTPSAKLRKLEVEANTAFDTYREMYFEGGVSSVYLWDLPEGFAGVILIKKVGDGSRKIKGSWDAIHVVEVTEKSGGQSTYKLTSTVMLWLQTSKAGSGIMNLGGSMTRQAENTVTVTDAAPHIANIGHMVEDMELSMRSTLNEIYFGKTKDIVNDLRAVSGLADKKKMVDMQKEIANTLKKRAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI70</accession>
    <name>A0A0D2WI70_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365842.2">
        <property type="nucleotide sequence ID" value="XM_004365785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI70"/>
    <dbReference type="STRING" id="595528.A0A0D2WI70"/>
    <dbReference type="InParanoid" id="A0A0D2WI70"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI70"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="127965" checksum="6CB042F38996469C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJC7</accession>
    <name>A0A0D2WJC7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 41B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_000931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365802.2">
        <property type="nucleotide sequence ID" value="XM_004365745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJC7"/>
    <dbReference type="STRING" id="595528.A0A0D2WJC7"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJC7"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJC7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="118"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="30353" checksum="01AAC49CE6B27DD2" modified="2015-04-29" version="1">MVVVTRSSSAAAAAGPIRATHTASQEPAKRRHIAMVLALVFGIAAAGLYAAYATFPELPSEQSTALRAALSWQGLVSGDKLTTVKLLSSTLQEIKKNHFAHVLALFMLTYIFLQTFAVPGSVFLSILAGTLFPFPLALALVCVCSATGASFCYLLSRQLGRQLVERAFPERLATWRAQVDRHRDNLFYYLFFLRVTPFVPNWFINAASPLIDMPLITFASSTFFGVIPLSLFHIQGGKLLNELTTTTPPLSAFLLSGGLGLIALLPTLFKNKLKERMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJN9</accession>
    <name>A0A0D2WJN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364525.1">
        <property type="nucleotide sequence ID" value="XM_004364468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJN9"/>
    <dbReference type="STRING" id="595528.A0A0D2WJN9"/>
    <dbReference type="InParanoid" id="A0A0D2WJN9"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="561" mass="61073" checksum="5D8827A6724676D2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJS7</accession>
    <name>A0A0D2WJS7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein mio-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJS7"/>
    <dbReference type="FunCoup" id="A0A0D2WJS7">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJS7"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJS7"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="1">
        <location>
            <begin position="467"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="887" mass="95453" checksum="FBD45AFAE48FBFC3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKQ3</accession>
    <name>A0A0D2WKQ3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKQ3"/>
    <dbReference type="InParanoid" id="A0A0D2WKQ3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="115" mass="13241" checksum="D56CE8754FF97CAC" modified="2015-04-29" version="1">MVRVSIEEMEECERRCHETVVVVVVVVVVVVTHDAVKARLPRVGMVVWLCRLFIRWGCFPFVSFVHFVLTSLRVAAWEKKVPHSDPVQPGVSCSCCCRRSVLYDAAHLLRWTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLF4</accession>
    <name>A0A0D2WLF4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TKL/IRAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLF4"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLF4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLF4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="628"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="916"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="972" mass="104679" checksum="899ED081E2E666A7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLK9</accession>
    <name>A0A0D2WLK9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0D2WLK9">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLK9"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLK9"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLK9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1381"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1406" mass="159519" checksum="5E43731AE633B465" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLW5</accession>
    <name>A0A0D2WLW5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349516.2">
        <property type="nucleotide sequence ID" value="XM_004349466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLW5"/>
    <dbReference type="STRING" id="595528.A0A0D2WLW5"/>
    <dbReference type="InParanoid" id="A0A0D2WLW5"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLW5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF18">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="193" mass="21655" checksum="A8E49E5729596B81" modified="2015-04-29" version="1">MASVADKIAAANALRLAGNELFQQNDLHRAARKYHEAILTVKGLDAKGGFASLLGVPGVPALSADYTSAINEMLINCYSNLTVCASKSMRWEKCIQYCDKIIALDKSHTKAHFRRGQAHLRLGFLDRAERDLKVAAANEPNDSAIQRELQLLHERQKEADREQKAFYSDMFQRMKLSNDSQQQPMQTDNSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM60</accession>
    <name>A0A0D2WM60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM60"/>
    <dbReference type="InParanoid" id="A0A0D2WM60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254578" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13778" checksum="3CDD0442BE2C19C8" modified="2015-04-29" version="1">MSAMRLTRLVLASFFVPASSTSRPLVPHSVGCLCRATRRRPGLCCNRRSRSHLQWQGQRDGRGLGATGSGCGRRLLTWILQTRQLPQLVDPLGVVAVAALERLDGSGRGHFLMQELALWWWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN10</accession>
    <name>A0A0D2WN10_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN10"/>
    <dbReference type="STRING" id="595528.A0A0D2WN10"/>
    <dbReference type="eggNOG" id="ENOG502QSP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN10"/>
    <dbReference type="OMA" id="RDCPDWL"/>
    <dbReference type="OrthoDB" id="284322at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="238" mass="26000" checksum="EF51D1D866946797" modified="2015-04-29" version="1">MVCPKRASLDPPLGSKFRFCGDLDCPDWVLAEISLLSKMTSVKMKLLVVQVIDSIIGGNIDYNKVFKLTSDAKYELSDVKASIAAISFIISSSSKYAVDGESLSNELQQLGLPKEHAGALCRAYADSLDKLQTLFKAQSLRLPTLKDSQWRVDYLLSSSELETIAEPSVTLNLTLETAVPKQTKKKPAELNADGEAVASQEAEQAQTVTSNVAFEISSDKFRLLFSELKHAHDVLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN55</accession>
    <name>A0A0D2WN55_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN55"/>
    <dbReference type="STRING" id="595528.A0A0D2WN55"/>
    <dbReference type="eggNOG" id="KOG2244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN55"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN55"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="835" mass="91681" checksum="68147028281D608F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNG2</accession>
    <name>A0A0D2WNG2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348451.1">
        <property type="nucleotide sequence ID" value="XM_004348401.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNG2"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNG2"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1138"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1277"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1391"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1474"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="867"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="943"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1394"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2223" mass="238973" checksum="8EAB091E993EF47D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNN9</accession>
    <name>A0A0D2WNN9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase ACSBG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363914.1">
        <property type="nucleotide sequence ID" value="XM_004363857.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNN9"/>
    <dbReference type="STRING" id="595528.A0A0D2WNN9"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNN9"/>
    <dbReference type="OMA" id="PNAMQGY"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNN9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="645" mass="70468" checksum="74986F9E32A91358" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNQ8</accession>
    <name>A0A0D2WNQ8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNQ8"/>
    <dbReference type="InParanoid" id="A0A0D2WNQ8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="95" mass="10290" checksum="A8CA2D2A2890AE0F" modified="2015-04-29" version="1" fragment="single">MGLEAANIESAKVRNMVVGMQIQPKSGASHSSPSVPREEQPTVSQLPPVGTATLGAFLHCASSHCNNHKITPEQKKDPEPQPRSLARRVNWLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPA6</accession>
    <name>A0A0D2WPA6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347792.1">
        <property type="nucleotide sequence ID" value="XM_004347742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPA6"/>
    <dbReference type="STRING" id="595528.A0A0D2WPA6"/>
    <dbReference type="InParanoid" id="A0A0D2WPA6"/>
    <dbReference type="OrthoDB" id="6147888at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026571">
        <property type="entry name" value="Tmem186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE93135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="300" mass="31264" checksum="5DE677471CABCE80" modified="2015-04-29" version="1">MTASGECAPASLSSKCLPGLAQRNSPVRHGAHAWIAAAPLLRRRWLSTRQLPQASVAAAAATTAATTSAMAQAQPPPPPTQPHFTVIYKGAGMQIWQLLARVKILHVAVVSGLVLPMAAVWAIDAQTQEASSETLENAATSSDPQLAAKVPPPPPPPRVTTATLAIAVASAAATGGVLVGLSLALRRYVGELALNLSTNEMRVATLSFWGRRVNQVYPAGAVIPQPFASSLGALTTKALHPMQLFSETRPFLLSVRYGRVVHPGLFLQLLRGELPAASEAPEAAATTFPSATPSDQPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRR2</accession>
    <name>A0A0D2WRR2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_005265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270491.1">
        <property type="nucleotide sequence ID" value="XM_011272189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRR2"/>
    <dbReference type="STRING" id="595528.A0A0D2WRR2"/>
    <dbReference type="InParanoid" id="A0A0D2WRR2"/>
    <dbReference type="OMA" id="IPGFFMK"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRR2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE94650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47469" checksum="A88A9108D494C301" modified="2015-04-29" version="1">MHHQCEVEGAAARRLNLRRPPPPLSQEAISFYESMPKLPTAGTKPAWARVEVHGFEVRVPAPPAVNISSARRPLGAFVPREELLQTTGLQCLPLQEHQSLAELFHGFWDGPMNLTLPPLYLSAISTVFSHHPDSTYLVHSNTLPLDQFDELRAMGFDIAVVRFDALRAVTFGNLPGRNWLRHDRVQHAGHRNVRSHMSDLIRTILMYQCGGIYMDLDSVLLRPLHFLNRAFTMEPMRPDHLRVQYTRMDGVSSLLSCSEVIVTRPQAVDEGGAMILTPYVVRGDFGLVPGLLAFGPRDPFIFMMMQVFEEPYNPDCFSCVGPVAVNKAYMASTAAERLRLQVYPADAMFGPFWRGVMDKFDEFWQTTTDERGQALVNDAIQFGFTQHLYGGGHGAPSFQKDSFIHRLVVETQLIPLPDLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSF0</accession>
    <name>A0A0D2WSF0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346703.1">
        <property type="nucleotide sequence ID" value="XM_004346653.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSF0"/>
    <dbReference type="FunCoup" id="A0A0D2WSF0">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSF0"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSF0"/>
    <dbReference type="OMA" id="LQKSGHY"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSF0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034783">
        <property type="entry name" value="SNX4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596:SF1">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="416" mass="47162" checksum="516A0AB02494FC64" modified="2015-04-29" version="1">MADEDYSPATTPSGSPLAGLEISIADAEKRKKSGEILSDPFIAYNIISKSKQNVPGFGSSEYYVWRRYSEFELLRNYLYMQYPTVVLPPMPPKRGNAGWTKIVDHFDPEFIEVRRVALQSFLRRAAQHPQLAADETFHAFLQQEAWSTSSAQLADRVEEKMKQLSASLKLKTQDNRFLDVKNYADNLNANLSALVKVQERLSKNMADMYESYGQTGPVFSDWAVIEKDIGDVLQSTGHFMDSLAPSVNEKLHAEEDQFTAVLREYTLFGDSLRTLVKRQEQKQYDLEKAEDSLASKVSSLEQLQGVTATGEPAPAGGKFSFKKISSKMFGPDTPEVREEKIRALEQQIEEGKGQVQIAQQELSTFCEDALRDVERFHKTKVADFKRVLVQYAKTQISFYKKGLQSWENMRTVVNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSL9</accession>
    <name>A0A0D2WSL9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346359.1">
        <property type="nucleotide sequence ID" value="XM_004346309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSL9"/>
    <dbReference type="InParanoid" id="A0A0D2WSL9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="365"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="843" mass="88887" checksum="C3DFE199DCFF6BB5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTV4</accession>
    <name>A0A0D2WTV4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345120.1">
        <property type="nucleotide sequence ID" value="XM_004345070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTV4"/>
    <dbReference type="STRING" id="595528.A0A0D2WTV4"/>
    <dbReference type="eggNOG" id="KOG4359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTV4"/>
    <dbReference type="OMA" id="PSFWFKK"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTV4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="136" mass="15370" checksum="B50B7521B829192A" modified="2015-04-29" version="1">MSADCVFCRISSGQDPSTTLLFENERLVAFRDIRPAAPTHLLVVPKQHIRDATLLDSTHSALVHEMNEVALKLLADHSLDGQDARIGFHWPPLVMIKHLHLHVIAPASQMSFLGRWLFWDKSPLFSPIAWMLDKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUI4</accession>
    <name>A0A0D2WUI4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Psf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_006035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345625.1">
        <property type="nucleotide sequence ID" value="XM_004345575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUI4"/>
    <dbReference type="FunCoup" id="A0A0D2WUI4">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WUI4"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WUI4"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WUI4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="199" mass="22951" checksum="7E77DC8672F2A26F" modified="2015-04-29" version="1">MSRYGARAVELLKEFRRSEANFLIGPYNEDAVRRIVQEVDELYAECLRISEAMKRTPEEIPALTSALTVHHSAMQRNKRCLLAYLQARVLQIEQVRWDFGQAPPASVRDSYSPFEQQYMSQYNQILQTYMGSVQCTLTEDLNPPKDLLAEVRCLTNEGEIVTENGTIVLRKNSTLFLRRSDVDMLIRQGLVEHVHSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WUR1</accession>
    <name>A0A0D2WUR1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WUR1"/>
    <dbReference type="InParanoid" id="A0A0D2WUR1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="125" mass="14170" checksum="6C6D96C0A10E59A3" modified="2015-04-29" version="1">MSPVMAARLRLMIHTHWSRRSPHERRGCLAKGLPSSTGRSQYGFVGLPVEVKCRILRFLDKKSLRVLRLVNREMRSICDDELALRIQSPELEPPSAEPAQPVQSRPIPRRTASLVATILIQADHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVC0</accession>
    <name>A0A0D2WVC0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVC0"/>
    <dbReference type="STRING" id="595528.A0A0D2WVC0"/>
    <dbReference type="InParanoid" id="A0A0D2WVC0"/>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVC0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="392" mass="42309" checksum="4D4B370B4E6A3039" modified="2015-04-29" version="1">MPLCCENDAQNFGIVHGSWAKQDQETLQLLLEDVLLRNMEASPELSSAFGHDLLGSTAGQLFLYNCLSSSMCCTRRSDDTSSPDPPHHARSELVGPATDANPFFPDSQNLSSSASSSSSATSSSSSRPRHQCKLFNLTKVGSEESSSDAAASGHDNKKLRQYLGVVGQAQLLQRLSAVVNQRDFCDNTRLHWSCFRGHTKCVDLLLKFGANKYMRDKSDRLPLHDAASHGFAACVRLLLCSGSVHHHRDHINHPHHWRAAHEPSISRRLSSGWILDKAEASTSKSSPYRSSSTKQGSKSPSVGALSAAEQKSSGTDMSDSPQTKCTGAPLQSDGHTCNLDPSCTEHEYVNARDCDGLTPLHGAAASGSWETVLLLLLHGADPDAQTVPGNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WVU9</accession>
    <name>A0A0D2WVU9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343372.2">
        <property type="nucleotide sequence ID" value="XM_004343322.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WVU9"/>
    <dbReference type="FunCoup" id="A0A0D2WVU9">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WVU9"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WVU9"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WVU9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270217" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="34"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="336"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="451" mass="49203" checksum="E4C4BFC317F91DA8" modified="2015-04-29" version="1">MHRRSSSSSAVTLSLAAAVMMLAVMMIVLCADAASTQAKVIRGAAPASRPLYRAAAKSGSFTCVDGSKTIPFAAINDDYCDCPDGSDEPGTSACPRGSFYCPNKRFVPTVLPSSRVNDGVCDCCDGTDELGRKESDCDNTCEEAGESLRLENEQKLLSHQQGMRVRFEHIKRGLTARKERTAKLRELKATLATEKAEDERLKAIKDEADALEKPAKEAHINAWNAVKEARRLEREAKKAEEDAAAAAAAAPEAASGEPTATEPAVDEKPEVKAEPEEPMPPFPEDVQALIDAANRAQTEWAALHDRATATEREVNALDAKLNTDLGPEQEFFVLQDECFSFKTNEYQYEVCPFVSAKQKQNDRATSLGSWTGWSGSGNKYSQMKFENGEKCWNGPNRSATVNLKCGDKNALISVAEPSKCEYVLEFTSPAACDPNFKLEQVEDDIEGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW39</accession>
    <name>A0A0D2WW39_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_006923</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344544.1">
        <property type="nucleotide sequence ID" value="XM_004344494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW39"/>
    <dbReference type="FunCoup" id="A0A0D2WW39">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WW39"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW39"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW39"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1036"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1147"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1163"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE96623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1191" mass="129831" checksum="5265079BA9644F95" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WW63</accession>
    <name>A0A0D2WW63_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_007625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343499.1">
        <property type="nucleotide sequence ID" value="XM_004343449.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WW63"/>
    <dbReference type="STRING" id="595528.A0A0D2WW63"/>
    <dbReference type="eggNOG" id="KOG4341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WW63"/>
    <dbReference type="OMA" id="CTITNRT"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WW63"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE97175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="786" mass="82815" checksum="6232C0A91C1F9141" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXB8</accession>
    <name>A0A0D2WXB8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIMD2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_007267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343126.1">
        <property type="nucleotide sequence ID" value="XM_004343076.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXB8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXB8"/>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXB8"/>
    <dbReference type="OMA" id="EAPRHRH"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXB8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="157" mass="17760" checksum="618F125E4362F360" modified="2015-04-29" version="1">MSTDSEPKKIGGFKPQPRVACEICDKTVYPMEQISADGHIYHKTCFRCQECKKILSLGAYSAVAGQVFCKPHFTQIFKTKGNYDTAFGKESLKAKWAPAPAAEPVRSSRYSEPKEEPRRQAPASAAAAEEDEPQQQEEEEEAPRHRHRDEEEEEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXQ1</accession>
    <name>A0A0D2WXQ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXQ1"/>
    <dbReference type="STRING" id="595528.A0A0D2WXQ1"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXQ1"/>
    <dbReference type="OrthoDB" id="2011727at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="11">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="288"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="12">
        <location>
            <begin position="926"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE98040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1228" mass="132973" checksum="73995B357B995A5E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXQ7</accession>
    <name>A0A0D2WXQ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_008087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXQ7"/>
    <dbReference type="STRING" id="595528.A0A0D2WXQ7"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXQ7"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXQ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="778"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="940"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE98050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1012" mass="104532" checksum="92BFCDB4E7B9887E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXU5</accession>
    <name>A0A0D2WXU5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343313.1">
        <property type="nucleotide sequence ID" value="XM_004343263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXU5"/>
    <dbReference type="STRING" id="595528.A0A0D2WXU5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXU5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXU5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="429" mass="44453" checksum="5496095337AEBB82" modified="2015-04-29" version="1">MSLIQAVQAGDTARIEALLLQAGLTGGAAAGAGAVEVMTVAAAAAPTTTTTTTTTTTTTTSPSTASAADMLGATDATGRTPLMLAAVGRAVAGSPLAAAQGQHDARVLTLILRAHQAITDQQQQQPQESSANSSKKCPDYLRRRSRNGWSALLWACKTGTLPSVQALLDAGANPCDKSTEPPQISAVALACEAGARETVQLLLARGARTALLGSPDVGAWAVMHAIKHGWIDDALEWVAAGANPRGVFAKRQTLLHLAVQHNQMRLVAALIAKGANVNLLDQYNMSPLLVAVHSSASNEILAELIRAGSRLHDIHYTLDNQSPLGYFAGQRGEAALAALKSLLQHVRKEQIQAMDHKPLFRALSIGSSDAVELLLKAGANPNLGAPSGESPLMFAVSLSTAALPPSPDALRCVQLLLAHGACSDDTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY02</accession>
    <name>A0A0D2WY02_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342901.1">
        <property type="nucleotide sequence ID" value="XM_004342852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY02"/>
    <dbReference type="InParanoid" id="A0A0D2WY02"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="157" mass="17848" checksum="B6DDBCB13C863274" modified="2015-04-29" version="1">MDSERLAAIQHELDGKEAVVASLEETNAALQGRYNACLQQHNMLQGDCEQRRKAITDLEHQRAADKTALYAARSRYKEQMKRLIDQQRQQKARQFDPSLLVAASAAVQADILSVEAPYKEIVEQRARFDHSLQPISLEAMEPKSQTLAIILRHLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY51</accession>
    <name>A0A0D2WY51_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydropteridine reductase</fullName>
            <ecNumber evidence="6">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="6"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY51"/>
    <dbReference type="STRING" id="595528.A0A0D2WY51"/>
    <dbReference type="eggNOG" id="KOG4022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY51"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY51"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266663" description="Dihydropteridine reductase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="266" mass="27748" checksum="4F5A738B37010793" modified="2015-04-29" version="1">MLLVSLFILVALSSLLLSLSIFPCSCTCITMSQHILVYGGRGALGTAIISYFKLRGFVITSIDLFANDEANHNVLLQAQDSWEDQSNKISAALAEKLGESKVAAVLCVAGGWAGGNAASADLIKNADLMIKQSVWSSVIAARVASQFLAPNGLLALTGARAALNGTAGMIGYGIAKAAVHQLTRSLAQPGSGLPEGATAVAILPVTLDTPMNRKFMPDADFSSWTPLDEISSHFLDWTTGKQRPSNGALVEVVTAGGVTTFTEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY73</accession>
    <name>A0A0D2WY73_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_007917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY73"/>
    <dbReference type="FunCoup" id="A0A0D2WY73">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WY73"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY73"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY73"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270267" description="Coatomer subunit zeta" evidence="13">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE97823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="185" mass="20544" checksum="C8B464574FB1EA3C" modified="2015-04-29" version="1">MSLRSAVVVVVAFASLASIKAVLTLDNDGERVLCRYFDPAWMASVKEQRAFEKSLFTKTYRAASDIIMLEGVTCVYKSSVDLFFYVIGAPDENELLLSFALNTYFDALAQMLRNQVEKRVVMENFDVVALALDELVDGGIILEADPAVIVQHVAVRNNDEVPIAEQSISQALQTAKEQLSRSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYE3</accession>
    <name>A0A0D2WYE3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_010170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYE3"/>
    <dbReference type="STRING" id="595528.A0A0D2WYE3"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYE3"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="287" mass="32050" checksum="F35EEA6D34F064B8" modified="2015-04-29" version="1">MSVFNPFDSLSAAAQLEQQNQQNQLHHQQQQQQQQQHQAHFLPPHQPQPQPQQQQQPHPHPQQQQQQQQQYFAPFYLPGQQAAASSSSSSPFVLPPQQPQQQPSHQQQQQQQQQQHAALQQQQQQQPQLTPSQPQQSQSLQHQHQHQQQQHQAVAAALLGGQADMATAAAVAAAAAAAMSSAAVPQPFAAEAVEEEPLYVNAKQYHRILKRRQARAKLEAENKISKERQPYLHESRHKHALKRVRGEGGRFQTKKGGDASSSNTPSLPDSLSASPTPENGQFLFGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYP8</accession>
    <name>A0A0D2WYP8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYP8"/>
    <dbReference type="eggNOG" id="KOG3864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYP8"/>
    <dbReference type="OrthoDB" id="10056090at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYP8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="130" mass="14267" checksum="74D8771C8BEBBD99" modified="2015-04-29" version="1">MSGKLRVNDSDSWVDSDSQLHGGQEMRLTDVDLSDSTVTPVGMQHFSNLKHLKRLDLSGNSYLTDDSIARLVDSPLQVLNVSNTPLTDKCVSSLTSMSALQELDVRETKLSVNARSRLQAALPKCQVHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYX9</accession>
    <name>A0A0D2WYX9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346393">
        <property type="protein sequence ID" value="KJE98338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYX9"/>
    <dbReference type="InParanoid" id="A0A0D2WYX9"/>
    <dbReference type="OrthoDB" id="2423641at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYX9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="702" mass="76989" checksum="06987690D2B7B6A3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X035</accession>
    <name>A0A0D2X035_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminoacyl-histidine dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364901.1">
        <property type="nucleotide sequence ID" value="XM_004364844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X035"/>
    <dbReference type="STRING" id="595528.A0A0D2X035"/>
    <dbReference type="eggNOG" id="ENOG502QRV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X035"/>
    <dbReference type="OMA" id="KGGYPGW"/>
    <dbReference type="OrthoDB" id="191370at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X035"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000015">
        <property type="entry name" value="Aminoacyl-histidine dipeptidase PepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000018">
        <property type="entry name" value="Aminoacyl-histidine dipeptidase PepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="CYTOSOL NON-SPECIFIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501:SF1">
        <property type="entry name" value="CYTOSOL NON-SPECIFIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="591" mass="63762" checksum="3132822048918643" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X050</accession>
    <name>A0A0D2X050_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X050"/>
    <dbReference type="InParanoid" id="A0A0D2X050"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="407" mass="44798" checksum="5E49BB208CA53055" modified="2015-04-29" version="1">MGKDAKSPAKGDDAKSAKSAKDAGKGTKKSKAAESSDDDDDASVSDSPQSYWQIFKLEDENKALKASIATLKQEAEAKDKAHDEAKKAVEKELEEVKKTLEKVKKENEVLLANVAASTAAKNTQSKGTLSLFKKKSETEAPAPASPTPAFTNPFEEVERLRGELAKFTDMTGEITLLKEREVEKDSEIAKYKEEREKLRYELQHLRQQVGSFKAANESEEDVLKRKAEAESKRQAEEAAKKKAAEDAQKAAEAQKAAEEAAKKQEESDEEDDPDFISTEAFEISIGDDQKVKLQLWSDKLHKFLTKDLPDAGEDAGALASVLKNSAKVTKDITALSRKIAPREFRTRNALLQKAVQCADEFKTATLDFSDHINQFVAGKIKSKKVAEAGAVVAKKARALNDYYKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0J2</accession>
    <name>A0A0D2X0J2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0J2"/>
    <dbReference type="InParanoid" id="A0A0D2X0J2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="227" mass="24521" checksum="D651C6562C8F6B7D" modified="2015-04-29" version="1">MSRKEASDGTKVESVQKSRGRGRRLQSRIQRCGVTTSGIESGQRLPRFEVGNHGNWRRLCIDFVGVAAAAIADIAATGILLHTGRIAATVTQIKDGARQEQSTNRVCRLSPLDEYLPGARNVLRQTVAVGQHVSEVQRRKRIFEWHHASEGEVGVEGGVGVSPSADENLQLERSKTLGWVGGGSGDIGVCSSKFAQINVRGRSLHKQLVQAVLQLRGGRSYGRATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0P3</accession>
    <name>A0A0D2X0P3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365754.1">
        <property type="nucleotide sequence ID" value="XM_004365697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0P3"/>
    <dbReference type="FunCoup" id="A0A0D2X0P3">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0P3"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0P3"/>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0P3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000074">
        <property type="entry name" value="Angio-associated migratory cell protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="47363" checksum="3CC58E36687FFBAF" modified="2015-04-29" version="1">MSRRTAPSSGPSRQSRGGVGRNARAEDDVVVNPEDIVEEIDDLDLNDAPNEEEMSDDDDAPEDDGDEPYTDEQQQWEDASAIGEGDTVEEWIDDSAGGFTEHSEPIYSVAINPANPTMIGTGGGDDVAYLWSRSDGSVIHKFVGHTDSVASVGFNFDGTYFATGGLDGSVKVWNTVTGALVVELDGPDEVEWLSWHPKGNVLLCGSGSGTSFMWQIPSGNVMHIFSGHNSRVTAGGFTSDGKSIVTASEDMSLIAWDPKTAEQVSKISAASDGRFHQEAITSLALSHDNVLVITGGADNKAIITHSKTGKIIASFEGHTDSVESVAFCSTMPWAASGSLDGTACIWDMSANRVRHTLKHDAGVIRVQFHPTLPLLITASLDHLVRVWDARTGSLLQDLHGHLAEPLDICVSNDGSFLISGGEDHHALIFHIQSQAQSQQPQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0R0</accession>
    <name>A0A0D2X0R0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_000955</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0R0"/>
    <dbReference type="STRING" id="595528.A0A0D2X0R0"/>
    <dbReference type="InParanoid" id="A0A0D2X0R0"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0R0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20793">
        <property type="entry name" value="C1_cPKC_nPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="17">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="243"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="383"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="644"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="718" mass="80638" checksum="C4AAF8D73BE12425" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X143</accession>
    <name>A0A0D2X143_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364374.1">
        <property type="nucleotide sequence ID" value="XM_004364317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X143"/>
    <dbReference type="STRING" id="595528.A0A0D2X143"/>
    <dbReference type="eggNOG" id="KOG0932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X143"/>
    <dbReference type="OMA" id="LEWTINE"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="233"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="576" mass="64056" checksum="4A2BC86E46B43601" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X146</accession>
    <name>A0A0D2X146_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_001519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364387.1">
        <property type="nucleotide sequence ID" value="XM_004364330.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X146"/>
    <dbReference type="FunCoup" id="A0A0D2X146">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X146"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X146"/>
    <dbReference type="OMA" id="LSICVGM"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X146"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7212" checksum="C609FB81FC160D43" modified="2015-04-29" version="1">MDTAQVREAKETMDVLFEMSKLLDTGLDRETLAICVSLCESGVNPEALAAVVKELRRESRAVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X158</accession>
    <name>A0A0D2X158_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364443.2">
        <property type="nucleotide sequence ID" value="XM_004364386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X158"/>
    <dbReference type="eggNOG" id="ENOG502R2N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X158"/>
    <dbReference type="OrthoDB" id="194566at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X158"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187:SF1">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="503" mass="54614" checksum="C0B0A8573253831A" modified="2015-04-29" version="1">MPTTSSTATRSAGTTSTTSTTSTSTTNGKHATSSNAGSNTNTNNNRAITPKQSQLAWALAIAQFLSLGGYWLMRPLKMGIFVQVVGLEHEPRAKLGTVLLLVPLLVLYNRLAARTDDIRLVVKIVIGTYATMFALIGALLFVPSVGFLHDPNAKAGTHVVKESTLGWCVGWITYWTIETFGSIVMPMFWSVVASVTTDHAPFVFSRVNTVMQLGAVLGATLATYAKELGIPQLCFFQVVVLGAVLLASRQAFLLSDEIQDEAELAKRKKEDASAPTNATNAPHAHHVPKETSTDLTTGLRLVFTHPYVASLLVISTAAEVVSTVMDYQLKVLAQNEYQTPEEMTLLMGRFGQAVNGVSLLFALFGSRAVMERFGIRFCLIAFPVCTLLLVGSVFIRPTLGVVFFGMVAIKALGYSLNAPSKEMLYRTTSKDIKMQAKSWIDMFGSRNAKALGSLVTELLKHNATELFRVGSLFSGGLSLIWLLAAEYLGVTYNRHIQNKTIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1A5</accession>
    <name>A0A0D2X1A5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_001779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364647.1">
        <property type="nucleotide sequence ID" value="XM_004364590.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1A5"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1A5"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1A5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001076">
        <property type="entry name" value="ATP-dependent DNA helicase MER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="336"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="561"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1316"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1619" mass="174653" checksum="E22B111982D7962B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1G2</accession>
    <name>A0A0D2X1G2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1G2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1G2"/>
    <dbReference type="InParanoid" id="A0A0D2X1G2"/>
    <dbReference type="OrthoDB" id="21443at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="2">
        <location>
            <begin position="379"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="749" mass="79728" checksum="EE8AFA4B5440027D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1I3</accession>
    <name>A0A0D2X1I3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Levanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348849.1">
        <property type="nucleotide sequence ID" value="XM_004348799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1I3"/>
    <dbReference type="FunCoup" id="A0A0D2X1I3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1I3"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1I3"/>
    <dbReference type="OMA" id="TFYDPIK"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1I3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255421" description="Levanase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="360"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63353" checksum="1A93084E2DCF1AD6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1J4</accession>
    <name>A0A0D2X1J4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_009502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1J4"/>
    <dbReference type="InParanoid" id="A0A0D2X1J4"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1J4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266740" evidence="2">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE90914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="175" mass="19344" checksum="A77CD4CFE2CCD124" modified="2015-04-29" version="1">MTDRARRRLHASTLLGDLTTLVHLAAGGAREACYLEHGSDQAARDRVDLHFLRPPQLQRPSARVHLTITDHIQPTQPSVVGLRPALVQLLKRTAAELAANLPFTYKTLLPVMGPAFFDMVKGIPFEELEASLRETRAMFESAAKKKSSSSSPNSKHSPEQRRSPLCQSFGVKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1N2</accession>
    <name>A0A0D2X1N2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349042.1">
        <property type="nucleotide sequence ID" value="XM_004348992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1N2"/>
    <dbReference type="STRING" id="595528.A0A0D2X1N2"/>
    <dbReference type="eggNOG" id="ENOG502R5I5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1N2"/>
    <dbReference type="OMA" id="YSHRILE"/>
    <dbReference type="OrthoDB" id="2340858at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1N2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="633" mass="71331" checksum="DE8413AF2497C3A7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1S6</accession>
    <name>A0A0D2X1S6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1S6"/>
    <dbReference type="FunCoup" id="A0A0D2X1S6">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1S6"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1S6"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1S6"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="391" mass="43190" checksum="DF394ACA77A717F7" modified="2015-04-29" version="1">MIVTLRFCVSSRRLGFGFFVRIRTLPLLNLAHKPKVFDSFCSSHFSHYSGTQKKIDSTHHTLPSTMNELRDSPATLVQHVPSLRIALNDPERPLHERFRVLFTLKNIGGAAAIDAIAECFKDDSALLKHELAYCLGQLQDTHAIPCLTQVLQDTNQEPMVRHEAAEALGAIGTPEVLATLVAHLEDPVVEVSETCQIAVARVKWENGGKQAAQQTGDFSENPYDSVDPAPPSAPATAAELRGRLLDTELTLFERYRALFALRNKGDPESVLAIVDGFDDKSALFRHEIAYVLGQMQHPVSVPGLIKVLERGESESSMVRHECAEALGSIATDECLPVLERYKQDNQRVVKESCVVALDMHAFENSGEFLTLEQGVEKIVREVKAKQESASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1Z8</accession>
    <name>A0A0D2X1Z8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_002785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349538.1">
        <property type="nucleotide sequence ID" value="XM_004349488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1Z8"/>
    <dbReference type="FunCoup" id="A0A0D2X1Z8">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X1Z8"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1Z8"/>
    <dbReference type="OMA" id="MMNQRLW"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X1Z8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="340"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE91684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="726" mass="82538" checksum="03A8D8E2C00B6B02" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X229</accession>
    <name>A0A0D2X229_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_002914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363753.1">
        <property type="nucleotide sequence ID" value="XM_004363696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X229"/>
    <dbReference type="FunCoup" id="A0A0D2X229">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X229"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X229"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X229"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE91839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="503" mass="55986" checksum="FC48CE4D96B08333" modified="2015-04-29" version="1">MSHSPVFRPSFEEVQELSSRGNMIPVYAEAFLDLITPVAAYLKLCLDQEYAFLLESVAGGEKLARYSFLGVNPYRVAKVGAGHEFTGDPLKPVEQELAKYKFVPIPGLPMFTGGAIGYISFDCVHSFEPHTAQPLQDNLPFLPEAIFMYCDTIVVFDHLRHQLRVVGHVRVPTSNHPEDLRSAYNSATQTVRQTLAQLCRVDTPVPVQGPIVLGNVAQSNQGQQGYERIVRDLKTHINKGDIIQAVPSQRLSRPTSLHPFNLYRHLRSINPSPYMFFIQLGEVSLVGASPEMLVKVDENNLVETHPIAGTRRRGKTPAEDDLLAAELLADEKERAEHIMLVDLGRNDMNRVCQPRSVKVPSLMHIERYSHVMHIVSTVTGTLRSEITPLDAFRSIFPAGTVSGAPKVRAVQLIQAQEQERRGVYAGSVGYFTYGGQLDTCIAIRTIVMHKGVAYLQAGAGIVFDSDPTSEYEETISKLNSSIAAIAQAERFYFDQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2G0</accession>
    <name>A0A0D2X2G0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">GPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_009664</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2G0"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2G0"/>
    <dbReference type="OrthoDB" id="10052455at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254985" description="GPS domain-containing protein" evidence="15">
        <location>
            <begin position="27"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2002"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2035"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2067"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2101"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2143"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2188"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2213"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="17">
        <location>
            <begin position="1669"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="16">
        <location>
            <begin position="1836"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="1999"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2267"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2276"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2331"/>
            <end position="2344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2380" mass="230169" checksum="09DF781A728FF3C0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2H1</accession>
    <name>A0A0D2X2H1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WASH complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_009679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2H1"/>
    <dbReference type="STRING" id="595528.A0A0D2X2H1"/>
    <dbReference type="eggNOG" id="KOG3578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2H1"/>
    <dbReference type="OMA" id="TFLHDEH"/>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="607"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="4">
        <location>
            <begin position="968"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE92549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1196" mass="136513" checksum="B32E3B77E77210B0" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2R4</accession>
    <name>A0A0D2X2R4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2R4"/>
    <dbReference type="InParanoid" id="A0A0D2X2R4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="350" mass="37032" checksum="E6A16467FF01187B" modified="2015-04-29" version="1">MHVHVLENVVEVVCCAVGALLHVALLLGFNAVCAVTVVDGTELFVAENAVGFVDELEQVLGLRVLVGMVLDGKLAEGLLDVGRAGIAWDTQRLVVIGTSRLAAGSLAGSRLAGEGGLGGVVLGNVDGLLAGSVFEVLVGLEGNERPHGISAAADCRQVERRVLFLVQTVEIGTLLGEQLDNVDKAALGSVMQGGLLHRAALLRVCALVQQELDHRVQVGEDGKVDAAFAVRCLVGHARAIVEQASEHGRLARLGGNVHRQLAAVVALGGRGEHFRVGHRALERALPKSRLGFQHLLDFNHVAGANSSKQLLHLLVAHGDKGERSNGSVFSEFCFRRWSTLKRVVFVSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2T0</accession>
    <name>A0A0D2X2T0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_003935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2T0"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2T0"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2T0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE93094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44853" checksum="69DFB94EA142EA9D" modified="2015-04-29" version="1">MLYESMTERQRELSDKAMDAEGLLYGNAEFNIAKYMYASILGDRQIGDDGAEAIAEALKVNTTMSELDLGKNQIGVAGAQSIAEALKVNTTLTTLYLDRNQIGDAGAEAIAEALKVNTTVNVLDLRLCHIGYAGVLALAEALKVNTTVTMLYLGKNAIGDAGAQAIAETLKVNTTLTWLNLPQNCIGNSGTRAIVEALKDSCRREVYISDQIRPLVFSLTPRLASAEDVQTVFHLLTSGLALEDQSASLPVLPVELAEHIMDEAQYWQGVQCTKRERFQADTPDVALKVTVPRSLDGNWVCVKSIHVLRDKATHDGDSDDSAFELIVRDEQGSVRCEFAAQPTFLDATLESLTIWPALAPIIRQMRGGWEVQVRPSKSVQDVGFESLYLGYVGPIFAMFECPAFSNARKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X370</accession>
    <name>A0A0D2X370_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat shock 70 kDa protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347284.1">
        <property type="nucleotide sequence ID" value="XM_004347234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X370"/>
    <dbReference type="STRING" id="595528.A0A0D2X370"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X370"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X370"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="573" mass="59796" checksum="EABC80DA0B37C096" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3N8</accession>
    <name>A0A0D2X3N8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346937.1">
        <property type="nucleotide sequence ID" value="XM_004346887.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3N8"/>
    <dbReference type="FunCoup" id="A0A0D2X3N8">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3N8"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3N8"/>
    <dbReference type="OMA" id="AFNKAMH"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3N8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE94634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="352" mass="39152" checksum="2A359F289F0929B6" modified="2015-04-29" version="1">MSDSQKPVASTATSLVPTAFLKGSIARDNVSTVASEYEAFYDDSKKDRVEERKSMYTTLVNHYYDLATDFYEYGWGQSFHFAPRCATESFVQSIVRHEHYLALKMRLQPGQKIADFGCGVGGPMREIARFSGAHVVGINNNAYQIQRGGIHNAKAKLEAQCSFIKADFLHVPVPDESFDGAYAIEATCHAPDRVAVFSEVFRSLKPGAYFSGYEWVMTSKYNPNDPKQVQIKKDIEEGDGLPDLIYDHEVVDALKKAGFEIVEISDLAETGDIPWYQPLAGSWSLSGFRMTWLGRLCTHAFVNVIETLRVAPSGTAKISSVLLKAAQGLVAGGQTKIFTPMMFFLVRKPERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X452</accession>
    <name>A0A0D2X452_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345493.1">
        <property type="nucleotide sequence ID" value="XM_004345443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X452"/>
    <dbReference type="STRING" id="595528.A0A0D2X452"/>
    <dbReference type="eggNOG" id="KOG1847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X452"/>
    <dbReference type="OrthoDB" id="5836667at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X452"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="413"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE95454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="466" mass="50526" checksum="C842069A46FF70F2" modified="2015-04-29" version="1">MLEAPRKRARDEDDDNDSAEQQRQRRNPHDIALDNNDNDNDNVNTDSSDDEDTMESDAMRNACFAPTYEQSNDPAPTKHAPLETPHQDDAAGQADEGAMASRQQHARPIILGAQTRLALNQLNPPPPPPPPPPPPPPPPLETSNKSDDQDESSEGSGENSTDDESDSDEELAIARAQLAEQRAAEAQQEQHQEAVDENPDAPEAEVKSDLGPEPSESVPETQTLVERASPPLNIPSWMLPPNDVVALPTQLKELEIIEKTARAVAVQGTQLEIVIKTKQRSNPLFGFLLFDHPLNPFYKHLLQLIKGPSSEANALQKGPQQVPGPVATPVLPAASVSASSTGASGVPHFMQAARLPVVALAPQVKPLSAPALIPTTLQSAAVPAPVQPVPLSVSAPPLPPSMDDTPPPHILEIVRKTVPFVARNGIEFEATLSSRNANDARFDFLNPWNPYHGYYRRALEQEMRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4A6</accession>
    <name>A0A0D2X4A6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345736.1">
        <property type="nucleotide sequence ID" value="XM_004345686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4A6"/>
    <dbReference type="InParanoid" id="A0A0D2X4A6"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4A6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35640" checksum="F470B50109069110" modified="2015-04-29" version="1">MGDRVDNVCRITRQDVDATSGVELPAEISDRANVITVEHPLELVPRSLALHLLDNITTAVNAPANAYLTGSGGVGKSTVLFILLVRALDYTARQLRQPPESPQRPLFVLYVASTASIARLRPDPAAASLCRILEMLNRPLLNLPQYADLLALLRPAIAPIRAHGVALAAWNAVCDYCAATTTFCSLFILDQWNAMFDPAVVVAGLPQDHPLQSLGFMGARFGVSMFVAAVSSSFDPLDAARGVFRDAEAHACKQMVRPLSHAETQVLQQTWLSRNPPVRISDNIMADLHRITGGIPRLCELFGSRPFASVEDAEFRNVASLLQVPMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4E2</accession>
    <name>A0A0D2X4E2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_009975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4E2"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4E2"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4E2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF20">
        <property type="entry name" value="P-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1439"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1514"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1545"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="497"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1603" mass="168871" checksum="FAD6456F6E3E6D10" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4H1</accession>
    <name>A0A0D2X4H1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_006423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4H1"/>
    <dbReference type="FunCoup" id="A0A0D2X4H1">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4H1"/>
    <dbReference type="InParanoid" id="A0A0D2X4H1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4H1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="111"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE96049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="231" mass="24730" checksum="450F4DF6C22A49C7" modified="2015-04-29" version="1">MGRVQQINQDSEFAPAITGAGSKLVVVDFFATWCGPCVRIAPFVDSLSTKYPNAVFLKVDVDKCKSVAQACGIRAMPTFQFFKNGAKIDDMTGADPAGLERKVQAHIGSGGSSFEGAGHYSLAPVIPTNGVQILNALGSEYHAILDDNETAIESDADQQLIISLRFNQGVNVHSLQFKAPADGRAPKTIRLYANRLAALSFDDTDSAPPRRAKSSSSPFRSTSSRTLKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Q1</accession>
    <name>A0A0D2X4Q1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_006775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344396.2">
        <property type="nucleotide sequence ID" value="XM_004344346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4Q1"/>
    <dbReference type="STRING" id="595528.A0A0D2X4Q1"/>
    <dbReference type="InParanoid" id="A0A0D2X4Q1"/>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Q1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255507" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="75898" checksum="D32B648E549DDDC1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4X0</accession>
    <name>A0A0D2X4X0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X4X0"/>
    <dbReference type="InParanoid" id="A0A0D2X4X0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266820" evidence="3">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="296" mass="31032" checksum="23057456F2AA8DC6" modified="2015-04-29" version="1">MQPAAVFVALLACSGFVTAVTAVDPSATVSGQNSQDSDSSTTIIIAAANGGGGFLLILLVVVAICRCRRKSKPQKLEQAPKDPASDIQVELNTVVTLPAPADSTAVGMTERQTAPAEQDIEPAAEREIVPAVRSNTGTSRRMPCKLPAEALDEPIVRDSGCELSNSSSFSSLNQSVPVSDRSTVYSKPSTIIPRSMTTSGASPYASSGPRALSNNNNSSNNSNNNTGTLTRSSTNPEPRISVSGYADPFSFKPKKKTPGLTSVTESGYAVPGEEPTVYGYANDHPRIVPDIFSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5P5</accession>
    <name>A0A0D2X5P5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5P5"/>
    <dbReference type="InParanoid" id="A0A0D2X5P5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="562" mass="61215" checksum="E4EF6BC435A06CA8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U280</accession>
    <name>A0A0D2U280_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_000826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U280"/>
    <dbReference type="STRING" id="595528.A0A0D2U280"/>
    <dbReference type="InParanoid" id="A0A0D2U280"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="52828" checksum="520B5742D79B4711" modified="2015-04-29" version="1">MSKPVAGDAPDRGGSRHRGNASGAHKSPASGGPRGGGGPGGRSGGAKHDGSEPLTTPIVLAKPTSSSSVHAAQPAAAAATSATTTAPTRVLVTKSSHSSSSASSTSEGQASSTSAASSSSAPGPSSSGSSHHNHIASICTWHMIGRAAVGGPLELLPPPATVQSSSFQPVHSILLNSDVSNYHVVGVLGRSGVGKSSLMNAVAVVLGRPATLLQSPITPATAEVAAAISATAPFATWKYKSSRRTVGAAPSDALKPPAPRQPATHLATSGIHTHMVGPVRTILMDTQPMLHFSNCSTNNSGATVTHDLAETLNVGLFLLSTCHTIVLVCDDVVADASLLRLLKTLVMLRPACTPTESVWRPASAGREDAPSEQGPPLPPGKEYRTLSAVIVLNAERWSNNAVHLAAQLSLFHELIAHVAPVVAHSLDLSADRIVVKTSTNHWRDVAEGVVAHFRQSSPIRPPIIAPLDPPATSQLLRVTEREWLRHVGHSWKSICTSPALADYLEVLRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U389</accession>
    <name>A0A0D2U389_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365933.1">
        <property type="nucleotide sequence ID" value="XM_004365876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U389"/>
    <dbReference type="InParanoid" id="A0A0D2U389"/>
    <dbReference type="OMA" id="TYSNLAY"/>
    <dbReference type="OrthoDB" id="10035179at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35286" checksum="1468A78BE21F2F1B" modified="2015-04-29" version="1">MHSVIAHADALLAFVYLAIVGLVVYAATGPLSDANFWASYTQDPGPWCERDRSRAFVREPSNAFTDFSFLAAGICMIACAARDLKHLRSHGLESQQANPLGGTTQASSVNKARPLNLIRANPILSVVFGVINIVHAVGTFTNHSCRCLEGHILDVAGMYSVIYLFLCLSALKYIHGAVVLAAKEKPLTLSDATLPDRAIAAFLLCLAAGVFGLYQISQLPYSDARTAPRETLTVASMVIVALILHAAYAHAVRSRIASQPRLIVIAVLLLIAAFGLHQMDIARILCNPDSLFQGHAAWHVMTCGSLSLVYSYHRNERWRTSETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3K2</accession>
    <name>A0A0D2U3K2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3K2"/>
    <dbReference type="InParanoid" id="A0A0D2U3K2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="164" mass="17907" checksum="7C6DE7EC75C21A47" modified="2015-04-29" version="1">MAASVCSKCSAHDATTDGMGGGGVRMRRSKRMESDLQTTSAFIRDLGEARIKHMEEGILTVVSRGMLVCTSVSYCSEQIFKNKTLCRTHKTARNEAQSLCSIVARSTLHVVMWSSCARPGKRIRTWPKSRVAVFSQTDPVSTVVHSCSSHELDSVPSGIHIHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4E0</accession>
    <name>A0A0D2U4E0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_001411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349931.2">
        <property type="nucleotide sequence ID" value="XM_004349881.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4E0"/>
    <dbReference type="STRING" id="595528.A0A0D2U4E0"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U4E0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000367">
        <property type="entry name" value="ABC transporter G family member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="144"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="938" mass="102948" checksum="691E42E4F545D072" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U889</accession>
    <name>A0A0D2U889_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U889"/>
    <dbReference type="InParanoid" id="A0A0D2U889"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="213" mass="19407" checksum="736E6506D6ADD614" modified="2015-04-29" version="1">MRVSNMSSSTTVPILPRSKSIDTVRTNESDVLAEALLDCEASALSTRAILAGAVGSIGSSAGRFCGAAATGAGVIVGGGVDVAVGVAEAGDLAAIGLRAAAAAGVEGLGLAVAGDVAEAAATVAGAGAGLATEVGVPTVDAGFACFVTVAAAGFGAGAAAGFGAGAATALAAGTAIGAASTCMGTAVEVSAAPAGTGSSAGATTGGWMALTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBM4</accession>
    <name>A0A0D2UBM4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UBM4"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UBM4"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265507" description="Membrane-associated protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="4516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4122"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4155"/>
            <end position="4175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4195"/>
            <end position="4219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4231"/>
            <end position="4254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4274"/>
            <end position="4300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4320"/>
            <end position="4338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="4344"/>
            <end position="4366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="3759"/>
            <end position="3816"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="3955"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="4119"/>
            <end position="4368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4389"/>
            <end position="4458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="4389"/>
            <end position="4409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="4410"/>
            <end position="4430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="4441"/>
            <end position="4456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4516" mass="469313" checksum="1688F0525843455E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDS7</accession>
    <name>A0A0D2UDS7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF6</name>
        <name evidence="6" type="ORF">CAOG_004040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347865.1">
        <property type="nucleotide sequence ID" value="XM_004347815.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDS7"/>
    <dbReference type="FunCoup" id="A0A0D2UDS7">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UDS7"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDS7"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDS7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="247" mass="26696" checksum="1E0C9D7C56ACA7C1" modified="2015-04-29" version="1">MAVRAQFESSNDIGVFAKLTNSYCLIGAGASENFYSVFEGELADRIPVVHTSIGTVRIIGRLTCGNRNGLLVPASTTDQELQHIRNALPDSVVIQRVEERLSALGNVIACNDYVALVHPDLDRETEEIIADTLQVEVFRQTVAGHVLVGSYCAFSNRGGIVHPYTSVQEQDELSSLLQVPLVAGTVNRGSEVIGAGLCVNDWSAFCGLDTTSTELSVIESIFKLQDAQPSAIVNQMRSSLIDGMMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDV3</accession>
    <name>A0A0D2UDV3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDV3"/>
    <dbReference type="STRING" id="595528.A0A0D2UDV3"/>
    <dbReference type="eggNOG" id="KOG2105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UDV3"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UDV3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="290" mass="30516" checksum="0F3F969E3E57C47D" modified="2015-04-29" version="1">MFVLIITDVVDIDRFVANARVVSLSRRAPAASTTQAAASAASSSSPGLDLVLDETIMHPQGGGQPSDVGFIQWDAQPERRFTVVDVRADKGAAAVVHHYGSFGSQDLDDAALATASAGAPVTIHVDESKRRLHARLHSAGHLLDSAVRNLGHTGLVPSKGYHFPDGPNVEYLGELEQTVRDGLPAALNIELQRLIATGGDVQVKYVPTSTLEGGGSGHSLAAPSAVPAQETSEPLRYDSPDAVRMVNIGGVECPCGGTHVKSIGDLQNVKVTKVKRAKGTLKVYYEVSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEJ1</accession>
    <name>A0A0D2UEJ1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEJ1"/>
    <dbReference type="InParanoid" id="A0A0D2UEJ1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEJ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE93536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="895" mass="97348" checksum="8C4EB147148D11DA" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEJ6</accession>
    <name>A0A0D2UEJ6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sac domain-containing inositol phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_004313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEJ6"/>
    <dbReference type="FunCoup" id="A0A0D2UEJ6">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UEJ6"/>
    <dbReference type="eggNOG" id="KOG1888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UEJ6"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UEJ6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="6">
        <location>
            <begin position="254"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE93541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129964" checksum="8CF422BF974316E8" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHQ9</accession>
    <name>A0A0D2UHQ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346916.2">
        <property type="nucleotide sequence ID" value="XM_004346866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHQ9"/>
    <dbReference type="FunCoup" id="A0A0D2UHQ9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UHQ9"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UHQ9"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UHQ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="372" mass="41505" checksum="8A47FECF9A31CF5A" modified="2015-04-29" version="1">MGDPYAVDASSLRTNLPAAVEDERLAVPVIDIAALAPGAPAADRQRVIEQLRFACRDVGFFYCAGHGVPQQLLDALFSTTLDFLAKPTEYKQRIAMSNSRVFRGWFALGGELTSYRADWKEGIYFGEDLADNHPDVLAKKPMHGANQWPDVQDFPEYKQTVTTYMSVMTELGHTIMEGIAESLGLAPDFFRKAFTANPFTPFRLFHYPADPVAKHENGEERWGVGVHRDYGCLTVLSSPNIIGLEIELKTGEWVKARQIPGTFVVNIGDMLEVWTKGVVRAAPHRVKNVSNVNRITAPFFFDPNFDCMINPLDITFSDDGKTATAVTAKDTDLSSLTTNPSIRSLTFPLRYGDYILKKVQNNFPELEQMSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIT4</accession>
    <name>A0A0D2UIT4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIT4"/>
    <dbReference type="InParanoid" id="A0A0D2UIT4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="325" mass="37246" checksum="0037F49B22E799F5" modified="2015-04-29" version="1">MRAWWMPIVAAGQPRAETAFVGARLCPNTHSTRRIHRRCHHCGRCDQCQRHQSRRRRRRRVVVLVAAGDCDREEIIHLPLVLAMTRRLVRRSSAESQVLGVWMTGWHQRHEEAFAGEWWRVHVEKWLLLRPPSVPCSCCWQRLGIHPTERCLARARPSRGLAIGRHQKAEWRRDRHSPGCQTCKLGFRSLDKPMGLVSHRLESNPSSIQPRQCSRETGGVRGRQAAEETACSCVLQRLRLRCRRFSVAATSQSREVPLRTARARLRRPESWAAKQQRVGSSPAASAPTFPRQTWHAARDSRGRQADPPCAHRRQSSETRPAQTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJH9</accession>
    <name>A0A0D2UJH9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346393.1">
        <property type="nucleotide sequence ID" value="XM_004346343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJH9"/>
    <dbReference type="FunCoup" id="A0A0D2UJH9">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UJH9"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UJH9"/>
    <dbReference type="OMA" id="DYGTDYS"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UJH9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE95246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="265" mass="28658" checksum="F5E92D71069D703A" modified="2015-04-29" version="1">MSSEIPNAARFASKVDNYVKYRPSYPVEVVRHLESIGALPAGAVVVDLGAGTGISAKLLLSNSANIAKLFAVEPSANMRAAAEASLADETAAGRVAFVDGSAHATTLPDASADLIVAFQAMHWFDPAQTRAELLRIAKPGAYLAAVWNHRFTENNPLNADLDQLLVKHAVDYAKVSHGALEEHKLPAFFGPGEIKCFKSSNSQTFDEEGFLRRQESSSYFPAPTHPNYDGAVAAVRALYAKYKDAEGKITLVYETRAYYAKVHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKT0</accession>
    <name>A0A0D2UKT0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345678.1">
        <property type="nucleotide sequence ID" value="XM_004345628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKT0"/>
    <dbReference type="InParanoid" id="A0A0D2UKT0"/>
    <dbReference type="OrthoDB" id="19798at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UKT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="366" mass="40934" checksum="FF50D521876AA3B3" modified="2015-04-29" version="1">MSDDEMWNGRDWACLILYTTLFAITGTLFALNVRKAETWRWNPQRLFFVLLLFQSAGRIVYFILAIGERNKYFPVNDVAISVTASIPASIFFTTFTVLLYTWSRVVTRFSRSLRGIGAFSSFTPFCILINVLVYFNVIIHFALRYSVEDGSNEDQVEHSYAYIIGAFSVLLALVFFICGLQLFFFLRSDPHYSSQARTNEMLTSISMLTMLCLFCFSFRASIIFVYLTDISSHFTVSLLYYTFSELLPSSVMLFIFRKLPDGAVEFAVANANRGGYGTMSTPRKRSSVRGAVTVGLHKAHDQGQVFPVTGGTEQSTFGVLATSASSSAVSSRFTTLYGPVGTDHSAMSTERLLDQVDEAGVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM61</accession>
    <name>A0A0D2UM61_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_009997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM61"/>
    <dbReference type="STRING" id="595528.A0A0D2UM61"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UM61"/>
    <dbReference type="OrthoDB" id="77037at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UM61"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE96156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="800" mass="86225" checksum="A84DB14BF60DB4A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPD5</accession>
    <name>A0A0D2UPD5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_007129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPD5"/>
    <dbReference type="FunCoup" id="A0A0D2UPD5">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UPD5"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UPD5"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UPD5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="435" mass="48492" checksum="D928832A26943B88" modified="2015-04-29" version="1">MAADAAKVASLATASRIVILAAQAALNAAIEDYDTSGPIGVVNQSRPEVQAALGGLARWDGVYMLRIAQMQEYEFEQISAFFPLYPAIVHAVGWMLGGSASSLLIAAAFVSNVCFVIATIGLFLLSKRVLNTDRHAGIVAALFMLNPANIFFSAAYTESLFAALTFWAFYFAERAFNPVQSRRAWLWHGTCAITLALSSLNRGNGMVSVALPLFLLVSQLRHNLLYQPQRRRVRLVLGNLLLACFYVTFAVGPFLWWQYRSYHEFCTSPEATRPWCSQSLPFIYSFVQEHYWNNGFLRYYELKQVPNFVLALPILVLAFATVGNFALTTLAEGRLRDFVLQGRTFQFAHCIWNSATFPYIVLTRFLCASCPAIFFGAANIVQPIKLRTNNTKNTTHSVMAHPTGIPGLQAIALVAYFVLYSMLGCLLFPNFYPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URT3</accession>
    <name>A0A0D2URT3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342847.1">
        <property type="nucleotide sequence ID" value="XM_004342798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URT3"/>
    <dbReference type="InParanoid" id="A0A0D2URT3"/>
    <dbReference type="OrthoDB" id="10581601at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URT3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="640" mass="68337" checksum="D2AE521507BA40A6" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USW7</accession>
    <name>A0A0D2USW7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE98051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342689.1">
        <property type="nucleotide sequence ID" value="XM_004342640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USW7"/>
    <dbReference type="InParanoid" id="A0A0D2USW7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="110" mass="12395" checksum="715D4055F97C5FC6" modified="2015-04-29" version="1">MSDEFDEQNSTAQPFKAKTFFHRLIPPPGDGMNVQIGDYVGQTIPTSSTRIDRPVLGALYTHPTCPRHGKVPRQLVSFVYTVQCIASVKDGSRQCRNRTSHTSKRCHVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTS2</accession>
    <name>A0A0D2UTS2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346414">
        <property type="protein sequence ID" value="KJE98396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTS2"/>
    <dbReference type="STRING" id="595528.A0A0D2UTS2"/>
    <dbReference type="InParanoid" id="A0A0D2UTS2"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTS2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="253" mass="27875" checksum="20166939B5C3DBDC" modified="2015-04-29" version="1" fragment="single">MSATPSVTSILAPDWGEDLSATELIAQEKSNLHKELEWLLRMEVPAVFMQLGLMLKDCAQTLAGPSGVSSAVAQASVFTAPITNTSDSVKGFAMLEGSRIIKADVTVRFSKWNKSLPISTSITSKEPWILSQIQNATNYVQLALSELDDSSLQHGLFHTREQVQSVMDRVMAFLRKAQDQLLFQSNLFPYNIDDLQLNAFNPRLPADLFVDFSINYAALNVSVYACTLLGTNQPARKPSSVARKKADMLIGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTZ1</accession>
    <name>A0A0D2UTZ1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Propionyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346443">
        <property type="protein sequence ID" value="KJE98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004339898.1">
        <property type="nucleotide sequence ID" value="XM_004339850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTZ1"/>
    <dbReference type="STRING" id="595528.A0A0D2UTZ1"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UTZ1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UTZ1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="279" mass="30664" checksum="41F5447878CB6773" modified="2015-04-29" version="1">MICKLITYGPDRQSALQTMREALDSYVIRGVTHNIPILRDMIDHPRFISGDISTKFIQEEYPTGFAKRELKDLQLHHLLSTAAALKATELVDNVSFQSKVARQDVVSEVASGVEAQEYVVLLDGAPHRIILSSVEGMSQVEFEDGSKLAVSEDSEAPTNHIRVRHFIVEEPCEHEDEELVDETAAASEDVEFEDSHDHISDVVTIQNLGSIPGGFKIGYLGGVYDVVFLTPREYELSKLMPKKAKADTSMMVVSPMPGTVVTIAVSAGDSVRTACSLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFM8</accession>
    <name>A0A0D2VFM8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365059.1">
        <property type="nucleotide sequence ID" value="XM_004365002.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFM8"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VFM8"/>
    <dbReference type="OMA" id="WADICAS"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VFM8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="598"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE88547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1057" mass="111198" checksum="843D5B564FEE0BCF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VG76</accession>
    <name>A0A0D2VG76_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365309.1">
        <property type="nucleotide sequence ID" value="XM_004365252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VG76"/>
    <dbReference type="eggNOG" id="ENOG502S8YY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VG76"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51101" checksum="7F652F959B4029CE" modified="2015-04-29" version="1">MDEPYVQSLGLCSLALAYCDMTVLFFFPLLPRLPLITTRAAFTQAALWSLLRLVIALPPIGMVIKAAVVLSVNNPESHVTPLIAWLVSCAYMLLAATILFYLVGDGHRTSSPPLGPLQWLLTTLTAPTPAQPTSSTKVSNAATTQAKQASVIAASKSNHPPMSQVALALAHGAFKLVLLAFVMRHWLKLRQQQSRPTVVMGPDGTLIREEVDFHVLGWVLRSSLYAVILYLLLSALLDFVAMVLALTMRVKLVDLWNSPFASASPRDFWGRRWNTIVRVIYNQALMRGLLLAGKAWNRVRQVDRMTAAGGAQVNADGELVFKGSDTKATARASSKSTTDTPPAAAKGGHAAASNAATPVSAPSEGLVYSLIAVNIVFGLLGLSHELIMWCTLGAATGENFLFFFLHGNACVLQSYIERTYPRFTAALTKESDLPATTLNMVFFACTSDLFFRPYLAADFFEKSFEMLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI77</accession>
    <name>A0A0D2VI77_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAOG_001063</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.86" evidence="7"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365934.1">
        <property type="nucleotide sequence ID" value="XM_004365877.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VI77"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VI77"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VI77"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000005">
        <property type="entry name" value="phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057509">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-RELATED PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24147">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="23" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="23" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="248"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="21">
        <location>
            <begin position="1340"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="22">
        <location>
            <begin position="1732"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="492"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1210"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1316"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1462"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1573"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1316"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1462"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1528"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1600"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1626"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJE89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1798" mass="191715" checksum="003B45BE32DFB8D3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIP7</accession>
    <name>A0A0D2VIP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIP7"/>
    <dbReference type="STRING" id="595528.A0A0D2VIP7"/>
    <dbReference type="InParanoid" id="A0A0D2VIP7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="215" mass="23389" checksum="533EF2E1F039AF0D" modified="2015-04-29" version="1">MSGAAALGTRKWNTSDQALNHFVNLLEHFCGSRFVEVYFFTSAPDTVGPAPLHARLRLAQIKPCISPLKSKNVTCTHCNAHFSTVVQAGVDVALATKVLTLVGEKALTGLFLLTGDGDFKEMLHYVTDVRHIPMWLAGFQKCTSTLLQAYANRGAILWLDEIWDAITYQPNYAANSRPVSHTAAANAAGPHAGHHHAGAHAEHAHPNMVYRKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ32</accession>
    <name>A0A0D2VJ32_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_001381</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349901.1">
        <property type="nucleotide sequence ID" value="XM_004349851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ32"/>
    <dbReference type="STRING" id="595528.A0A0D2VJ32"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJ32"/>
    <dbReference type="OMA" id="WCAEQKV"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJ32"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000360">
        <property type="entry name" value="RAB9B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF1">
        <property type="entry name" value="RE17845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="211" mass="23007" checksum="1934E90FC1AB5ACD" modified="2015-04-29" version="1">MAAAALGAAGSGAAKSVLLKVVILGDGGVGKSSLMNRFVNNEFDAQSFHTIGVEFLNKVVALNNESYTLQIWDTAGQERFKSLRTPFYRGADCCLLVFGIDDEQSFRNLTMWKKEFLYYADVADPEHFPFVVVGNKIDVRARQVRSEDAEAWCKANGGLAYFETSAKEAIKVEQAFLAAAQQVPKSDGPVATDYSNSVNLAETPGKRTCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJI1</accession>
    <name>A0A0D2VJI1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364321.1">
        <property type="nucleotide sequence ID" value="XM_004364264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJI1"/>
    <dbReference type="STRING" id="595528.A0A0D2VJI1"/>
    <dbReference type="eggNOG" id="ENOG502SF2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJI1"/>
    <dbReference type="OMA" id="DNRYMHL"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="99" mass="10472" checksum="BA7B8E685AF6722F" modified="2015-04-29" version="1">MSGMPGGTSNARDADAETQSILDQVKSQAEEKAGKSFSQFVAKQVATQVVAGTNFFVKADIGNGEQVHVRIFRSLPPAQALSVHSIQTGKTASDPLVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJT3</accession>
    <name>A0A0D2VJT3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="9">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="9"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364465.1">
        <property type="nucleotide sequence ID" value="XM_004364408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJT3"/>
    <dbReference type="FunCoup" id="A0A0D2VJT3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJT3"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJT3"/>
    <dbReference type="OMA" id="ERGLHPW"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJT3"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000002">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="297" mass="31977" checksum="C17D7DF05004DA1A" modified="2015-04-29" version="1">MSTHPRDESDAAAAAPAAKRSRLESVDEFYETAVAVAREAGATIRAAFDKNKSVMLKSASTDLVTETDQKVEAFIINSFKDKFPSHKFIGEESVAAGIQCELTDDPTWIIDPLDGTTNFVHRFPFVAVSIALVIDKAPVIGIVYNCILDEMYTAVRGRGAFKNGVQITTSQQTAVNTALIGTEFGSNRKDEVLATILENMRSLAGEPNAAHSIRCLGSAALNLCAVASGAMDAYFEFGIHVWDIAAGILILQEANGVVRNPDGTELDIMARRILGACTPQLADEITSRIKNIVTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKL6</accession>
    <name>A0A0D2VKL6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="5">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_001866</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="5"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364734.2">
        <property type="nucleotide sequence ID" value="XM_004364677.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKL6"/>
    <dbReference type="STRING" id="595528.A0A0D2VKL6"/>
    <dbReference type="eggNOG" id="KOG3749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VKL6"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKL6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="14">
        <location>
            <begin position="48"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="13">
        <location>
            <begin position="273"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="641" mass="70066" checksum="5E31D27DA9393319" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKT0</accession>
    <name>A0A0D2VKT0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_001932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKT0"/>
    <dbReference type="STRING" id="595528.A0A0D2VKT0"/>
    <dbReference type="InParanoid" id="A0A0D2VKT0"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VKT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06612">
        <property type="entry name" value="STKc_MST1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000605">
        <property type="entry name" value="serine/threonine-protein kinase 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF2">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE90657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="466" mass="51436" checksum="3A6F0D7057F81A4A" modified="2015-04-29" version="1">MAANLVLDEAALKKAPEEVFDVLEKLGEGSYGSVFKARHKDTQSILAVKQVPLENDLQDIIKEISMIKECDSPFIVKYYGSYFKDTDLWIIMEFCGAGSVADVMRLRRKVLEEPEIACILQHALKGLSYLHSKLKIHRDIKAGNILLNHEGVAKLADFGVAGQLSDAMAKRNTVIGTPFWMAPEVIQEIGYDVKADIWSLGITAIEMAEGRPPYAEIHPMRAIFMIPTKPPPTLSEKDKFSESFNDFLAKCLKKNPAERPTAAELLEHPFIKNAPPISVLSKVMTEALALIAEKGLNPDDDEDASGEAGTVIPGTTKSYVDAATLVDSGTMVTGDSGTMVMGEDGTMKLSSDGTYKPQFLSRFGKKGLSENVPSLEQVMPIVSIFFSLYFFTFLLFSSRSLLLLRSKTAWGGFGRSRMWRLSAFWELCMLFPSLYPFSTLQFLFSHGHSEGLGGRGCGGVSRNHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLH8</accession>
    <name>A0A0D2VLH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol-4-phosphate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348939.1">
        <property type="nucleotide sequence ID" value="XM_004348889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLH8"/>
    <dbReference type="FunCoup" id="A0A0D2VLH8">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VLH8"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VLH8"/>
    <dbReference type="OMA" id="QMGVARR"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VLH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17301">
        <property type="entry name" value="PIPKc_PIP5KI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="733" mass="79471" checksum="BF9F3E6361188F3F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMM9</accession>
    <name>A0A0D2VMM9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Jumonji domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349321.2">
        <property type="nucleotide sequence ID" value="XM_004349271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMM9"/>
    <dbReference type="FunCoup" id="A0A0D2VMM9">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMM9"/>
    <dbReference type="eggNOG" id="KOG2131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMM9"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMM9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="176"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="496" mass="55768" checksum="E90BDBD40251C06D" modified="2015-04-29" version="1">MSEPIQLLASSTDLSYDDFVAQFMAPNRPVVLPESAIRHWRARHEWTTDAGATTGSDAVVVRNIDIDRIEALFGQAVAPISDCDVTQTYGMAGLVGTGRSDDGQPLLKEVTIAKYCDYLRRRRQHVQRQSRSTGTSVESRDGSIGKPGKPGDHDGTIVSDPLPADRCIYLKDWHMTRDFPGYNAYELPVYFSDDWLNGYWDECGSLDQNRRDDFRFCYIGPAGSWTPVHFDVMSSFSWSANICGRKKWIFFPPEAREMLTDAAGELLSDVRSVDETRFPNFRNAPRIELFQEEGQLVFVPSQWYHQVINLTDVISINHNWANGCNILGMWQLAKEDAQLVATDLSLESASLDEISTSKQHGAVAAVRSPAAPAAMFGLMAATAEQAMTVQDLLRANGSLDFRAMHDLCMVQVRKIQQRSHQLALLAPSAVTAEVCAARNRHVSDLKTIRQILTDISRSTFYRECRDAWPASIDIEQELSEQETLQRRLTELFESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNB9</accession>
    <name>A0A0D2VNB9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_008642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270253.1">
        <property type="nucleotide sequence ID" value="XM_011271951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNB9"/>
    <dbReference type="FunCoup" id="A0A0D2VNB9">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNB9"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNB9"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNB9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="489"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="729" mass="80860" checksum="000E9555ABD72C3C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNE7</accession>
    <name>A0A0D2VNE7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_009596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNE7"/>
    <dbReference type="FunCoup" id="A0A0D2VNE7">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNE7"/>
    <dbReference type="InParanoid" id="A0A0D2VNE7"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNE7"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000024">
        <property type="entry name" value="Indole-3-glycerol phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="13">
        <location>
            <begin position="358"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="13">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE91837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="593" mass="62957" checksum="AE622D37D9D7C9AF" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNT9</accession>
    <name>A0A0D2VNT9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNT9"/>
    <dbReference type="STRING" id="595528.A0A0D2VNT9"/>
    <dbReference type="eggNOG" id="KOG4272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNT9"/>
    <dbReference type="OrthoDB" id="5804096at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNT9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253756" description="TM2 domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="236" mass="25079" checksum="6F5B89E13914E1C0" modified="2015-04-29" version="1">MTLSRLLLQLLAVLGALLVATCSATTLKRSNDHHHLANEPHHYLQYASKPHNHQGHSDASGVRRRDAAAAAAAASTLSTATLETRPCSSLNIGQYMCDQPAIDPDTQAEVGCPASAPFVVAVPCRPVAGVVCDGVTFDGNTTGFSRNVSCRYTAGTRYDTALLLSVFLGVLGVDRFYLGYPAIGVIKLCTFGFFLVGYLVDVLLILLQVVVPADGSSYVGSYYGMLRIDEPTPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ16</accession>
    <name>A0A0D2VQ16_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270340.1">
        <property type="nucleotide sequence ID" value="XM_011272038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ16"/>
    <dbReference type="InParanoid" id="A0A0D2VQ16"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41587" checksum="57E09C37656980FD" modified="2015-04-29" version="1">MKRLWASMWTDPPEAIKKELAVHPKPRILAYRWLMSACQALQFTPLRVSRTIPAATQPPDNVSAESTQAPTELSAEPMASIPATAQLVSAAQPAAKLSPKALQTVQEFLQLYDRRIPIKLNSPGIDASEHLPASQVLKPFVDKGSEWMSAEALDFCFGRLQQANITSQNGVKVTFWQTFNANGTADMDRSLRGHSNREIRFSECKDSLSDTVAASEDGLVIFPANREQHWFLVVLHRKTFTIRIFEGLKKLALDLVEIVKSFLPDSTEWSFVPEPGSIYGHQGPGQTEEPPWTCGWLALWMAERIARLGVSAEDLQASTSNPWPWVPTDPPPPNVGQPSRSQAVPPLSLLIAEHVRFKWLADAARCWTPHVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ28</accession>
    <name>A0A0D2VQ28_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO acetyl-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363295.1">
        <property type="nucleotide sequence ID" value="XM_004363238.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQ28"/>
    <dbReference type="STRING" id="595528.A0A0D2VQ28"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ28"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ28"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="438" mass="47814" checksum="7A7B82ABF1A8DF04" modified="2015-04-29" version="1">MHVYSRARRLAADGTDDHSSRDNNHHHNKTTTDEASKDSSAQHSRAADLWNMIAQEDEQRPSSPRVCPPSPSSDATAFGACSDVRSDPLSSDGSDWALADEFQPLDSEPSSSLSDDLDPARAADRTTLVASDLVKDSGMAIESASQDTALPDQSRRIGVPSSHGYRLGDLFASPRIMLSNDILSGRGRMLPLSSASARVVKAKSRQLVARKQPVQQMLDAGQKLECKTCGMIMAAHDEQAHLKHHEELQMRKEGLVPRSHRWESTDLATDARTSGMLVEVRKSDLFFDTVVLPLMSADLGLLSVEEASQLRKFLFITRDTPQRAVGCVMLEEFNPTTMTIISPSNSSGPAASASSTSASTKPAAKVVLGVNRIWVSKAFRKFHIATRLLDFARAHYYTVGTVEKANIAFTPLTDNGRAFALAYLQETNAPPVEYHHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQ81</accession>
    <name>A0A0D2VQ81_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF5898 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_009697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VQ81"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQ81"/>
    <dbReference type="OrthoDB" id="20660at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQ81"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045417">
        <property type="entry name" value="DUF5898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19250">
        <property type="entry name" value="DUF5898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5898" evidence="6">
        <location>
            <begin position="480"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1479"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE92757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1505" mass="158545" checksum="3E25DDB61320A780" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR90</accession>
    <name>A0A0D2VR90_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_004162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347987.1">
        <property type="nucleotide sequence ID" value="XM_004347937.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR90"/>
    <dbReference type="InParanoid" id="A0A0D2VR90"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="205" mass="21330" checksum="F4D383CEB4B0A451" modified="2015-04-29" version="1">MALLASQASGLRALVRAATSTSSSTATATLATSMIAARATPAAVSVRSLSSLQSSVAHSPAMLLHAIRSGSALAPAGFATGATAASPSTSLASAAAANAHAVGLLSGAAGSALAVSPAASPLLAQAVRCAHKRVLKKPRLYKLKSRSAVKRRFRLMANGRYKRRQAGKQHLNIHKSRKRKNRLAKTVLTTNTHTKTIRRILVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRN6</accession>
    <name>A0A0D2VRN6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348150.2">
        <property type="nucleotide sequence ID" value="XM_004348100.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VRN6"/>
    <dbReference type="eggNOG" id="KOG2405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRN6"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="728"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1550" mass="163191" checksum="00C4C67666181F18" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV60</accession>
    <name>A0A0D2VV60_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="13">PARP</shortName>
            <ecNumber evidence="13">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_005786</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="13"/>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346459.1">
        <property type="nucleotide sequence ID" value="XM_004346409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VV60"/>
    <dbReference type="STRING" id="595528.A0A0D2VV60"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VV60"/>
    <dbReference type="OMA" id="HHITTDN"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VV60"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08002">
        <property type="entry name" value="WGR_PARP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="15">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="18">
        <location>
            <begin position="188"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="16">
        <location>
            <begin position="455"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE95327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="668" mass="71930" checksum="8D4BCB6F17E1F310" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWL5</accession>
    <name>A0A0D2VWL5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-Mg/Pi carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_006350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345099.2">
        <property type="nucleotide sequence ID" value="XM_004345049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWL5"/>
    <dbReference type="FunCoup" id="A0A0D2VWL5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VWL5"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VWL5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="81"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="474"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE95972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="567" mass="60143" checksum="773D1C73E29EB916" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VX82</accession>
    <name>A0A0D2VX82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_008992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VX82"/>
    <dbReference type="InParanoid" id="A0A0D2VX82"/>
    <dbReference type="PhylomeDB" id="A0A0D2VX82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="866" mass="94461" checksum="83D2C60D6C01EEBC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYE2</accession>
    <name>A0A0D2VYE2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_010045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYE2"/>
    <dbReference type="InParanoid" id="A0A0D2VYE2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE96737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="122" mass="13462" checksum="A043FB29367510E2" modified="2015-04-29" version="1">MTLCWGFCELNKHGQIATDAEIVGCTNAGPKKDSKRGSLIQPTQTNQSTTTKEGQRVTLCFCASTSSSPKMTPKRACFWSAAAAAVWRDVSRPAGSSSRCVWHWRRVLLRGIHCQLPKQKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W0L7</accession>
    <name>A0A0D2W0L7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342950.1">
        <property type="nucleotide sequence ID" value="XM_004342900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W0L7"/>
    <dbReference type="InParanoid" id="A0A0D2W0L7"/>
    <dbReference type="PhylomeDB" id="A0A0D2W0L7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="302" mass="33701" checksum="B5ADC1061D8537DE" modified="2015-04-29" version="1">MLQSAFNSFACKRLSAFSRAFGVLSFSPPPPLLLSRVPRGLFHSQQQSSEVETTKPVLLVGGPDDELFYQKYTTLGQHAQFKTAGAFDRKAVSHIMRQTKLKHAFLSDSNMYAASPNLAAAQAQISKNVGVPVVYTLLPRIESYLILSEMLTRSEEAYALRHHAIRVIYKHMDYFFTSFKSMREESGLGLSTKSSETAPNDQQNKVFTAVDRLFPRMDPNGPEMLWSELVHQQRVNASSSSFDPVGFWTTYVKMVDGKKAMVRGPDGEPRSTDAMICKTTCLHPKVQALLDQTVQAALQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W100</accession>
    <name>A0A0D2W100_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_007999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342600.1">
        <property type="nucleotide sequence ID" value="XM_004342551.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W100"/>
    <dbReference type="FunCoup" id="A0A0D2W100">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2W100"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W100"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W100"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE97932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23289" checksum="4361A5F565815ED8" modified="2015-04-29" version="1">MFVVSTFRNTIRIHPADFAKDPQTAIADEINRLYANKVVLNIGLCICLYDLTEVGDAYIVSSDGSTRTEVVFRLIVFRPFEGEVVSGTIRRSIPSGIIVNIGTFFDDVFIPAENLQPGTIFNPDLQEFVWTFAEQELRMEADSRIRFRVVADRFSDLTPVHTEAPRFVDNDIAVTRTVASAEDPYKRPYMVIGSASDSGLGLEAWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1M6</accession>
    <name>A0A0D2W1M6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_009185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270902.1">
        <property type="nucleotide sequence ID" value="XM_011272600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1M6"/>
    <dbReference type="STRING" id="595528.A0A0D2W1M6"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2W1M6"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1M6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE98227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="872" mass="96236" checksum="654AB2B5B440FD36" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGW9</accession>
    <name>A0A0D2WGW9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGW9"/>
    <dbReference type="FunCoup" id="A0A0D2WGW9">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGW9"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGW9"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGW9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="140" mass="15083" checksum="BC2B98B36A7F7B04" modified="2015-04-29" version="1">MSSDVQWMVIRNNSSFLLKKAGVTFSTEAGNLTGKNSFKANGLVNKRSVGVKAAADGKGVVVTLRNDKKSFKPTKATRSVTLKKGSRAALATVKALTEGQNYRADLTHDALRLTSALFQSQKTRKTAGVKKARSRKVAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WHE6</accession>
    <name>A0A0D2WHE6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_000594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365465.1">
        <property type="nucleotide sequence ID" value="XM_004365408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WHE6"/>
    <dbReference type="FunCoup" id="A0A0D2WHE6">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WHE6"/>
    <dbReference type="eggNOG" id="KOG2200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WHE6"/>
    <dbReference type="OrthoDB" id="10003330at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WHE6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF7">
        <property type="entry name" value="CROSSVEINLESS C, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="423"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="739"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="875" mass="97249" checksum="EEE2163B2B50864C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI84</accession>
    <name>A0A0D2WI84_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MRPL25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365855.1">
        <property type="nucleotide sequence ID" value="XM_004365798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI84"/>
    <dbReference type="InParanoid" id="A0A0D2WI84"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16379" checksum="5B4D4D64E9714838" modified="2015-04-29" version="1">MVAPTLSRTLLMMGFQAATMPVFRNGAWRPPMLSKREVAQSLKLFGPGIVPAPKVSNWQPTHAKGHLYDIQKGTRQAKVDKIMETMQAQKDALRQERRNYRITVRADSKPVASDTYTEADQLASKLKRERLMAKKEAKKEKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ64</accession>
    <name>A0A0D2WJ64_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_000802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365673.1">
        <property type="nucleotide sequence ID" value="XM_004365616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJ64"/>
    <dbReference type="InParanoid" id="A0A0D2WJ64"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="454" mass="50540" checksum="CFC7756C3EA9021B" modified="2015-04-29" version="1">MAAVIVCPEPYISPNCTETFGEHLGAAPIVTHSIYGALVAVLCTLAVYNLYMVVRYKNGWSLDIQNIVLYFVVYGAFGMLLRAFDPMSWYGIVPYWVNSYAYATSTACCFAMFFSMVWSWMGFVSKTTFRPWYRKFLNRVYIGSLIVIFFVSYLALILKFTHVLLTWEGDVVVFIMLITLNVVWSSAGAYHGTLIWRTLRASYKRFGYSSTSGQDDSSHPPVTGSSVPGELTTRASTTAANADKVKQKMMRKRAHALRRIAILNFLSIGVGLIAIGVIAYGIGSRISAKRDIDTNPMDPPTIGTLIQNYQFDIIHFVVMFPAIFFFRYARPQRTTEDVDIDMSSTSHGRNTKHEVTTHIDDEIELEEQVDSAGVSPALPRAQIPAVARIKEEEATPSTSSTDRMSVHSTTVEIMNSSASRLPDAEADVEHFQQLSLADGANVVVTVDSQSSQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJU7</accession>
    <name>A0A0D2WJU7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004366020.1">
        <property type="nucleotide sequence ID" value="XM_004365963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJU7"/>
    <dbReference type="FunCoup" id="A0A0D2WJU7">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJU7"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJU7"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJU7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="191" mass="21178" checksum="3B864B4F5255B980" modified="2015-04-29" version="1">MPKEPSARSDPDTNHPYKESKAPAKPVALPDGWEIRHSATKKRAYYFHVPTQKSQWEPPALNSNAEDESESNDASNSSTMSQVRASHILAKHKDSRRPSSWKTQNITRSRDEALAMIQQWRAQIVNKEKTFADIAKVESDCSSAKSGGDLGFFGPGQMQAPFEHATFALQVGELSEPVFTDSGVHIILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WK44</accession>
    <name>A0A0D2WK44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_008552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WK44"/>
    <dbReference type="FunCoup" id="A0A0D2WK44">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WK44"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WK44"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WK44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE90555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="137" mass="15490" checksum="B843986257AFDC35" modified="2015-04-29" version="1">MDASAIPLTSRLGRDMQVYHDGVRQVAGCVITRRDTGGQREILLVTSRAKQEWILPKGGWESDESIEESARREAIEEAGIVGRITRSLGSVQVASKNGNSTSCIHWFELAVDQVLDQWPEQRERSRKWVGLHHQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLA1</accession>
    <name>A0A0D2WLA1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349214.1">
        <property type="nucleotide sequence ID" value="XM_004349164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLA1"/>
    <dbReference type="FunCoup" id="A0A0D2WLA1">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLA1"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLA1"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLA1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="262" mass="29197" checksum="B10E3CAE44CB0E12" modified="2015-04-29" version="1">MAVGKNKRLTKGGKKGSKKKIADPYAKKDWYDIKAPSMFTTRQVGKTLVTRTTGTKIAADGLKGRVFEVSLADLQGGNEEEAHRKIKLCADEVQGKNLLTNFHGLDFTTDKLRSLVKKWHTLIEAIVDVKTSDNYVVRVFVIAFTKRRPNQVKKTSYAQHAQIRQIRKKMTDIITKEVSSADLKEFVAKLLPESIGKEIEKACQGVYPLQNVFVRKVKVLRKPKLDMGKLLELHGDSGASSEDTGAKVERGDFVEPAILASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLA3</accession>
    <name>A0A0D2WLA3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting 13B isoform 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349218.1">
        <property type="nucleotide sequence ID" value="XM_004349168.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLA3"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLA3"/>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2737"/>
            <end position="2757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3902"/>
            <end position="3938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3916"/>
            <end position="3938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="4668" mass="493158" checksum="79E2205496E441AD" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLP0</accession>
    <name>A0A0D2WLP0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">microtubule-severing ATPase</fullName>
            <ecNumber evidence="7">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLP0"/>
    <dbReference type="STRING" id="595528.A0A0D2WLP0"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLP0"/>
    <dbReference type="OMA" id="KMATERI"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLP0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="344"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="586" mass="62234" checksum="1FD8CAF14FB2C4D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLR4</accession>
    <name>A0A0D2WLR4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348896.1">
        <property type="nucleotide sequence ID" value="XM_004348846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLR4"/>
    <dbReference type="InParanoid" id="A0A0D2WLR4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="107" mass="10877" checksum="120859C8F7928256" modified="2015-04-29" version="1">MAPVRNKSAGASKPLKTTTLQVTSSSRIAAEAQAPLSQPPTADAMPVIARVSTAQLQGKVKACASMHRDGATAPAAQPQRYAGPFCAPPKASALPMPPVQWLSASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WM97</accession>
    <name>A0A0D2WM97_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349149.1">
        <property type="nucleotide sequence ID" value="XM_004349099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WM97"/>
    <dbReference type="InParanoid" id="A0A0D2WM97"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WM97"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10305" checksum="125B8A9AC80B5A67" modified="2015-04-29" version="1">MADEFPWCLTIDVPFPTARLATIAYNTLVVDEEPKKSDVRKTLQLLQNDTVLSIHFAAREGRLLRSATQSMMNFLRLTIDTMLAFPDYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WME9</accession>
    <name>A0A0D2WME9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOD3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WME9"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WME9"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WME9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47339" checksum="18DC797ABEDE7081" modified="2015-04-29" version="1">MLSYQNMNENQRRLYDEAKEANRSGWLDLRHNEIGDAEAQAIAEALKVNTETNTILQGTLRSLMMCDNRIGDAGAQAIAEALKVNKSVITLYVEGNQIGDAGAQAIAETLKVNTTLTVLDVSDNQIGDAGAQAIFEAIKVNPTVTFIDLHTNEIGDAAAQVIAEALKLNKTVAKLRMDLNQIGDAGAQAIADALKANTSLTALSLGRNQIGTAGALAIAEALQVNKTLTSLYLQYNCIGNVGVEAIDEARKVHGTSEVSISDQINPLAFSLLPRLATAEDLQAVFCLLISGSELQDQSASLPVLPPELAERIMDEAHYFQGVQHTKRSQFSAAFFGLALNVTLPRNSVRVKSIQVLRDCRASLDEIAFDVNIRDDQGAVRYECAAKPAFVESTIQLVTICPASHPFLRQIRESWQVQVQPSKVSANLRFESLYVGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMJ0</accession>
    <name>A0A0D2WMJ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Ero1l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_003084</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363923.2">
        <property type="nucleotide sequence ID" value="XM_004363866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMJ0"/>
    <dbReference type="FunCoup" id="A0A0D2WMJ0">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMJ0"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMJ0"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMJ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254484" evidence="20">
        <location>
            <begin position="36"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="469"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE92055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="569" mass="63258" checksum="A7E17B7F42CDA08B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMQ5</accession>
    <name>A0A0D2WMQ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_003199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364038.1">
        <property type="nucleotide sequence ID" value="XM_004363981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMQ5"/>
    <dbReference type="FunCoup" id="A0A0D2WMQ5">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMQ5"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMQ5"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE92185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="352" mass="37745" checksum="71FB07E23705668A" modified="2015-04-29" version="1">MLAADVASSSADAGATAGPGAGAGAAGGPPPPPPPMMLPVKSAVTALSSSLSLSSSSSASSSKKPGLSLRDLIGEKQPEMEAEADLSEEQLKHSQLDLPRVQCPRCEKLVLAVNIAEHANSHSSEVVPGLFLGGMRNAHNKIELTKRTNVRHIVNVAEEVENVFEDCAVGCECSNGVEHNPPKVPHGAPAEARLFIYHSLKIKDALGEDALGLFDSTFQLIHDAIERKEPVLVHCVAGISRSASVCIAYLMRSRKWSLKLAFQHVRSARSIISPINWFILQLQTYEQRLAQTMELEGFHGQPSLTVADVYPEGTRFISTHIVPPAPIPFSIPAAAKQPEIVFDSEAKRTDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMZ2</accession>
    <name>A0A0D2WMZ2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349491.1">
        <property type="nucleotide sequence ID" value="XM_004349441.1"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMZ2"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMZ2"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMZ2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002270046" description="TNFR-Cys domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="1236"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2316" mass="243084" checksum="61D68B83CCD4F907" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNF8</accession>
    <name>A0A0D2WNF8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_003534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348439.1">
        <property type="nucleotide sequence ID" value="XM_004348389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNF8"/>
    <dbReference type="STRING" id="595528.A0A0D2WNF8"/>
    <dbReference type="eggNOG" id="KOG2133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNF8"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNF8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="271"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="8">
        <location>
            <begin position="434"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="622"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="752"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE92610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="97180" checksum="E2169131D58FC67E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNL2</accession>
    <name>A0A0D2WNL2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_003654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNL2"/>
    <dbReference type="STRING" id="595528.A0A0D2WNL2"/>
    <dbReference type="eggNOG" id="KOG0505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNL2"/>
    <dbReference type="OMA" id="TIDARMH"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNL2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="115"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="415"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="775"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="808"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE92745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="864" mass="91424" checksum="2B49A40EF3310CF1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNY0</accession>
    <name>A0A0D2WNY0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Double-strand break repair protein MRE11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAOG_003231</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNY0"/>
    <dbReference type="FunCoup" id="A0A0D2WNY0">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNY0"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNY0"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNY0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="18">
        <location>
            <begin position="490"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="750"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="876"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJE92218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="929" mass="100791" checksum="499082832F11E64D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPA5</accession>
    <name>A0A0D2WPA5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPA5"/>
    <dbReference type="InParanoid" id="A0A0D2WPA5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="398" mass="44540" checksum="50F49C05542014AB" modified="2015-04-29" version="1">MYKLFCDAEHDPFNPTTGTEVSFLDWKTLHRIVYLPLHRNPVASGDAEKDVRIEASFDAKFVAQNNFAGNALNYNLMAILDCERRTKIVIKYQRTPVHLADAGLKELERYFLSKSTGKLRLQVSLDDPNMELHLTARQVAKLHGDKSYRLLTLSHIQLRATKRMIKEGGFSIPVGAIVNAVTSTVGKALASTAIRNATKGAIEGATRSLVSKMETYCLRCKSKTEDVDPAEVTTPKGRLQRKSKCGVCGAQKSRFLKQEKSGGMFVKGYTGDTRLDMATPSGMTREDQRFNSKTVWTVIETGLRNALNILQYIPLPGVQLFSTVGSVALGAKDLAEIKDTIAKLKAQTATQRDEFINQQVNLVYDNWYENEVTKNSPRPYYFVMYDRVRSAILAVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPD1</accession>
    <name>A0A0D2WPD1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPD1"/>
    <dbReference type="InParanoid" id="A0A0D2WPD1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE92498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="286" mass="33329" checksum="D8728F2F621B3E38" modified="2015-04-29" version="1">MFKHHHISPEEIERLKAEGISPGQHTAEQVHEDELDELQFGDRHFGGQAHTHVDRHGKLYAAKFDELGREIDEDGNLMTVMDIIERRLHHSQFEGREPPEGLFKRWDIENKEPPILYYQEKHWEGLEPPWAEEERELAIFMNAECEVTELREAYHAACYRHGHLIPCTTVCMMAFHRYYDRLIEPKCLKGTIHHTPTSEHLRWLLLAHDAEIAHHCPDKYRVMDVREMHALHMMIDKSQPDNPELGLDDTAHAGHLHMQKKPTSAERKGIDADLPGHGFNVKLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPM6</accession>
    <name>A0A0D2WPM6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348029.1">
        <property type="nucleotide sequence ID" value="XM_004347979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPM6"/>
    <dbReference type="InParanoid" id="A0A0D2WPM6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="568" mass="61804" checksum="CEF3C537FE0BC76F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQ82</accession>
    <name>A0A0D2WQ82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQ82"/>
    <dbReference type="InParanoid" id="A0A0D2WQ82"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQ82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE93760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="239" mass="26058" checksum="C70E5AB8C8F9D921" modified="2015-04-29" version="1">MIGIVVAPPTLPEPAFDAFLSPAGAVLVPSFGAIQFPTFGGVRSRIERNCERPNLLIWPRRSRSTSASGPPSGTEAKAPAATVNPSAEDDRALIDRLPEALRKSFEAKWEAPALRKHLLEKLSTAQLFLSQKNAISVVQTELSAFASVVPEAISDTEQRRRTGGPELYPKLPNRLIAETVLDWIRLWSKNQAFMTVEELEGKLAQFSAREPSPAQEMANKAVSLDCDDEAWAAVGNQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQA4</accession>
    <name>A0A0D2WQA4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_004548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE93805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347295.1">
        <property type="nucleotide sequence ID" value="XM_004347245.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQA4"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQA4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF122">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="1298"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="358"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="920"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1400"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE93805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1414" mass="150115" checksum="3F0618944453291C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQP1</accession>
    <name>A0A0D2WQP1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_004726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQP1"/>
    <dbReference type="InParanoid" id="A0A0D2WQP1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="95" mass="9952" checksum="8E466630A4C44120" modified="2015-04-29" version="1">MQDPITCPRPNSPHSLLASSSMPTISLRTTPTPGTIMGYSATCLCSSSRATCRGSIPTPQPGAILPSIASEPTLALPLTLRLACTWSTLSRIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WS23</accession>
    <name>A0A0D2WS23_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WS23"/>
    <dbReference type="STRING" id="595528.A0A0D2WS23"/>
    <dbReference type="InParanoid" id="A0A0D2WS23"/>
    <dbReference type="PhylomeDB" id="A0A0D2WS23"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="443" mass="50959" checksum="022E7AF83D0E32B4" modified="2015-04-29" version="1">MSSLQQPAVDIEQHALLRVKRSRDEAPAETLFIETSHKRAREDFARRFGSHRLGQPAQDDESDPRSAIPQVLSHREAQELKRQQELQAMADQSKPVLFQYVTTVSARALRSQAGVQKVQSVIEQERLRRRQAVAFKANPFVKTAKERQTAARERNAEARYQWITARRHFDDGEDLDEQSGNEDPIANLGFRVYDLQRLAERQTPKLKAKSDQIVMNMIPLVRERLRMRGRDDTDPDEIANELPFVEAEQARHLAELERSFQAQRLDAQKAAAEMNHFGASDEDDGPRPPEVLRAADLPAASESAADESEPVVDIYMETTDATNPLSTPDAFPVIPFPEEALVDDGELSDDSNYYEDDDDENDENNYRNDYPDEDEYEEDNHRSDSDNDERVFDVINRLDSDVEEDDSDEEFDETSEIAASARAQYGADWMTRFRQWRERQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSU1</accession>
    <name>A0A0D2WSU1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSU1"/>
    <dbReference type="InParanoid" id="A0A0D2WSU1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="138" mass="15111" checksum="F14E6E568C29AFAD" modified="2015-04-29" version="1">MRRAAVKTGRAGVRTRRAAVMGRRRPSTAASKLKRAAGFIALRQAVATAWRRPAVATATRRTAAATAMRRLAATALRHGGDKKMSDLPIPKVPNRFCSIDSTDQTAGALLEFRSELKFIGELARWRAWHEAGCCGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTT8</accession>
    <name>A0A0D2WTT8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMGC/DYRK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_005609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTT8"/>
    <dbReference type="STRING" id="595528.A0A0D2WTT8"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTT8"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF130">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="295"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE95123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111767" checksum="BE90BF9E46D1ED36" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTZ0</accession>
    <name>A0A0D2WTZ0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTZ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WTZ0"/>
    <dbReference type="eggNOG" id="KOG3833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTZ0"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTZ0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017510">
        <property type="entry name" value="RtcB2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007153">
        <property type="entry name" value="PRK09588.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03073">
        <property type="entry name" value="release_rtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="370"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="430"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="518" mass="55314" checksum="7798CA7EB88AED37" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WV53</accession>
    <name>A0A0D2WV53_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_006378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE96003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345127.1">
        <property type="nucleotide sequence ID" value="XM_004345077.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WV53"/>
    <dbReference type="STRING" id="595528.A0A0D2WV53"/>
    <dbReference type="eggNOG" id="KOG1830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WV53"/>
    <dbReference type="OMA" id="FFFDLWK"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WV53"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22057">
        <property type="entry name" value="WH2_WAVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE96003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="577" mass="61354" checksum="B259A7DE8D274329" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWH8</accession>
    <name>A0A0D2WWH8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclease Le3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_007127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343851.2">
        <property type="nucleotide sequence ID" value="XM_004343801.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWH8"/>
    <dbReference type="SMR" id="A0A0D2WWH8"/>
    <dbReference type="STRING" id="595528.A0A0D2WWH8"/>
    <dbReference type="eggNOG" id="ENOG502QRXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WWH8"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WWH8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254839" evidence="9">
        <location>
            <begin position="31"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE96873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="343" mass="36958" checksum="32ACA9EDE83868F8" modified="2015-04-29" version="1">MHFRSSSSSLLSAACVVIAVAAFAVRSADAWGAQGHQITAAIAQALLTPEANNYVIRMLPTSDNKSLAVASTWADDIKNQAQWKWTQPLHFIDTPDFACNYNYNRDCIDVGTGTKDACVAGAINNYTGILVNAGPKDVSELLQDSLKFVDHFIGDIHQPLHVGFTSDLGGNTIEVNYNGVNVNLHAFWDYSAISNRIDVDFNGDQNAYVNYLLQKIHSGWGGYVAMWNNSCNAVACPDIWATESVIFACNSSYADINRNITTVITTAYYNRAIDVIEQRLAAGGIRLGASLNRVAMSVNDTANNAMVGAVIGSVLGAVVLVIVAALVVAALRKRRGRTGYTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WWZ9</accession>
    <name>A0A0D2WWZ9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343525.1">
        <property type="nucleotide sequence ID" value="XM_004343475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WWZ9"/>
    <dbReference type="InParanoid" id="A0A0D2WWZ9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="158" mass="17368" checksum="D7BF6390C170E463" modified="2015-04-29" version="1">MASAYNRPMPPTPPYKRTGCLDSTVKTMTSTRVAANARELWTTGELVPHSRVMDESVLCGKIVTGFLQGYAAQAAYDQWRVEHKVELLRPLPFELRTEPPPKEMLWPVGFEASVAAFHEAMKHAEAAWEDQRSYEEAHHHASASSKPSAAAGVGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WX38</accession>
    <name>A0A0D2WX38_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_007760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WX38"/>
    <dbReference type="InParanoid" id="A0A0D2WX38"/>
    <dbReference type="PhylomeDB" id="A0A0D2WX38"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="422"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE97650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1045" mass="108237" checksum="8528180E6DC983D4" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXF2</accession>
    <name>A0A0D2WXF2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_007942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343030.1">
        <property type="nucleotide sequence ID" value="XM_004342980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXF2"/>
    <dbReference type="InParanoid" id="A0A0D2WXF2"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="295" mass="32998" checksum="AC0BABF4751C7FB7" modified="2015-04-29" version="1">MDRTLGDVIDQHLILSSILNLPADHEIRKWPVADVALVDWPVMQQLLNEELPVDDKPATKAKRLVAFNLLQHLLDQATIGAPPVVPHLRESDTPTRFKGVVNGVLSLTNGAVLSAAAVVDSSTQPFASMDLLQQYLEDRLGNLARLEIVTLDLSGNDLRNSDMPYIVTLVQALKCPVVKLRSNRLGMGVPTTDNNSPVHYLVSLAAEKYVRFLDIVNNYVSAVDWDPAYRQFTSNNETTWRKLVYLPLSWVSTHKWQSSICGEHTDAAMDCHNKFYWAGLTDPVFTRSDQLPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WXR8</accession>
    <name>A0A0D2WXR8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAOG_007416</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343275.2">
        <property type="nucleotide sequence ID" value="XM_004343225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WXR8"/>
    <dbReference type="STRING" id="595528.A0A0D2WXR8"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WXR8"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WXR8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255340" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="44"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="210"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJE97583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="436" mass="47211" checksum="C5FD7096AC0CCC38" modified="2015-04-29" version="1">MTMTRMLLALVALAAVAIVAAPSSVNALPQQLSAAAAAATPSVNVCKFADWETGLQVDLSALRAAVAFNNAKNWKYSTKDASGTTSYYLNVCDQLVTADPELPVECANSYACQSASNHKNFSAGTQIYNSGIYVENIDSGIIMMKTIGGTACSSGARSTIISFICDPRAHSLDGPEDVDEDDHCVYEVDWPTKHACTQLPSPATSTGYHLSIDSTNGETFDFSKLRKLVGNWVVNMPNGTFVLNVGQPINGLDFQPSISQCSPTSGACHLWSDTDPNLGVLDVNSRSLGISSTGRIYFDANGKLNYNMTGGSVYSSDPKCKGIARSINIRFECSSQINRPQFLDESNCGYHFLWASIVACPVVEGEGSDSSLSGFAIFVIIFLVLVFTYCFGGCCYKRHKLDAKGWEQIPNYDLWSKCCSICDTRRNVMERTRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WY07</accession>
    <name>A0A0D2WY07_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342488.1">
        <property type="nucleotide sequence ID" value="XM_004342439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WY07"/>
    <dbReference type="eggNOG" id="KOG4189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WY07"/>
    <dbReference type="OMA" id="FSHACTL"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WY07"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="213" mass="24012" checksum="AD039066691E51DB" modified="2015-04-29" version="1">MAAEPFSFPKVVDMFERVDTHAGKAANEIETIPFLDAYFELSKVFDHLGRAFKFVTADVVEKIDILRKHHELRENAHSTLDGMLRHELENNLTDTTSSGGLRSGSRTLLRLNRALEFILAFFDRMIEAKEDAACSTLAGEAYANTLSKHHGWAVRSAVNLALYTLPSLSELIRRLDVSRDDGIAYLKRIVASVRPMYDHINGLYTTHDLHSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WYF0</accession>
    <name>A0A0D2WYF0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_008010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="6"/>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342611.2">
        <property type="nucleotide sequence ID" value="XM_004342562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WYF0"/>
    <dbReference type="STRING" id="595528.A0A0D2WYF0"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WYF0"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WYF0"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF395">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="599"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7 8">
        <location>
            <position position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE97943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="933" mass="102933" checksum="A04F6F2480C29727" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0C7</accession>
    <name>A0A0D2X0C7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Countin2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0C7"/>
    <dbReference type="eggNOG" id="ENOG502S5J5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0C7"/>
    <dbReference type="OrthoDB" id="17754at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0C7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254932" evidence="1">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="264" mass="28569" checksum="88BA0C497483AF3D" modified="2015-04-29" version="1">MIMFVISSNSHSWFFFFRMKAFLAIAVLALVLGVASAAPNHKLTRKVQSPDANLCPVCVEFAGDALNELINIVLNVGVIGSCGEVCGLLTNRTHSRAEGLVCDLLCDYVGITEFIKAIEKADLDPIYYCELLNTCAINDNGDATIRSFTTSPVSGPQGTTFTFDLDWSTINGTGTGEIILVVQTVDGLQLGDSSLLEATAPGEYVKRWQVDAKPDPDCDPTQDECEEWLPGQYIVQMAICNGECGSKHPHSMVFAQAQSSFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0E4</accession>
    <name>A0A0D2X0E4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365358.1">
        <property type="nucleotide sequence ID" value="XM_004365301.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0E4"/>
    <dbReference type="FunCoup" id="A0A0D2X0E4">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X0E4"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0E4"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0E4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="199" mass="22204" checksum="C52746CF3C171CFA" modified="2015-04-29" version="1">MDCIIAISGKDFVVAAADAMAARSIVVMKSDHEKMVQMSPHLLQVCNGPSGDVVQFSEFIQKNIKLYQMRNGFALSPHAAAHYTRDQLARALRSSGAYQVNLLLAGYDTINKQAELYFMDYLAALVKVPFGAHGYASHFVLSLLDRYYTPEVTLDEALRLMKMCIAEVQKRLVINLPKFTVRVVDAQGTRDVTLDDVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0H9</accession>
    <name>A0A0D2X0H9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365509.2">
        <property type="nucleotide sequence ID" value="XM_004365452.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0H9"/>
    <dbReference type="STRING" id="595528.A0A0D2X0H9"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0H9"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0H9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="379" mass="41434" checksum="2F203A90577BA9E5" modified="2015-04-29" version="1">MQSITGLSRLSSRVASAVRMGAARQQSRSFHASRAAHAAGFNFYPDVAPAELGETKKMNLYQAVNDAMNITLATDPTSVVFGEDVAFGGVFRCTLDLAKRHGADRVFNSPLCEQGIVGFGIGMAAAGATAIAEIQFADYIFPAFDQLVNEAAKYRYRSGDLFNVGKLTVRAPCGAVGHGGHYHSQSPEAYFAHTPGLKVVVPRSPIQAKGLLLAAIRDQNPVVFFEPKIMYRTAVEQVPIGDYTLPLSQAEIVQEGSDVTLVGWGTQLHVLRETAKLAEEKLGVKCEVIDLRTIMPWDVDTIEKSVNKTGRLLIAHEAPLSGGFAGEIASTIQDRCFLRLEAPIQRVCGWDTPFPLIFEKFYMPDTLRCFEAIKKMINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0I7</accession>
    <name>A0A0D2X0I7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0I7"/>
    <dbReference type="STRING" id="595528.A0A0D2X0I7"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0I7"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0I7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="365"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="733" mass="80798" checksum="5F799C03E1E6B3A7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0T1</accession>
    <name>A0A0D2X0T1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_001037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365908.1">
        <property type="nucleotide sequence ID" value="XM_004365851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0T1"/>
    <dbReference type="STRING" id="595528.A0A0D2X0T1"/>
    <dbReference type="InParanoid" id="A0A0D2X0T1"/>
    <dbReference type="OMA" id="HRHIANL"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0T1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="440"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="6">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE89599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="73551" checksum="60E6D5DCD44EDFE9" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X0U5</accession>
    <name>A0A0D2X0U5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_001104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365975.2">
        <property type="nucleotide sequence ID" value="XM_004365918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X0U5"/>
    <dbReference type="STRING" id="595528.A0A0D2X0U5"/>
    <dbReference type="eggNOG" id="ENOG502QVA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X0U5"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X0U5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="324"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="656" mass="69551" checksum="77536BA7663481A5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X100</accession>
    <name>A0A0D2X100_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349862.2">
        <property type="nucleotide sequence ID" value="XM_004349812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X100"/>
    <dbReference type="InParanoid" id="A0A0D2X100"/>
    <dbReference type="OrthoDB" id="69088at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="915"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1224" mass="132207" checksum="51225273D2EBC9D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1N8</accession>
    <name>A0A0D2X1N8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349065.2">
        <property type="nucleotide sequence ID" value="XM_004349015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1N8"/>
    <dbReference type="STRING" id="595528.A0A0D2X1N8"/>
    <dbReference type="eggNOG" id="ENOG502SGYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1N8"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395637" description="Autophagy-related protein 27" evidence="7">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24600" checksum="E7218542FE0246DE" modified="2015-04-29" version="1">MMMMARLAPTLLVVLAAIVTLAAADSFDLQQCKYTTSTNEIIDIAGLRQSTPLRVGPFQDGSITYYVYYNFCPNLGSSPIPACKKDAIMCLSTGAAIATTLTNVAGLNVDFSGDTATSSRLHLNCDKSITGAPSMTLTKSSLTWVVTLSHQCACPGVCPVASEGGGISGGSILLAIFFPSVFVYLVVGVLIKRRGGATGTDAIPNIAFWREVPGLIKDGFKFVFSCGNSGYTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X1W4</accession>
    <name>A0A0D2X1W4_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X1W4"/>
    <dbReference type="eggNOG" id="ENOG502QVIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X1W4"/>
    <dbReference type="OrthoDB" id="205699at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042023">
        <property type="term" value="P:DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038859">
        <property type="entry name" value="RHL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35698">
        <property type="entry name" value="DNA-BINDING PROTEIN RHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35698:SF2">
        <property type="entry name" value="DNA-BINDING PROTEIN RHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="692" mass="74065" checksum="2349AE0721F26D27" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X2S2</accession>
    <name>A0A0D2X2S2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_003902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE93054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363630.1">
        <property type="nucleotide sequence ID" value="XM_004363573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X2S2"/>
    <dbReference type="FunCoup" id="A0A0D2X2S2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X2S2"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X2S2"/>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X2S2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE93054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="534" mass="55717" checksum="E2C8F0F4ABF42985" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3C6</accession>
    <name>A0A0D2X3C6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_004769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KE346366">
        <property type="protein sequence ID" value="KJE94074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347520.2">
        <property type="nucleotide sequence ID" value="XM_004347470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3C6"/>
    <dbReference type="FunCoup" id="A0A0D2X3C6">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3C6"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3C6"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3C6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="121"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE94074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118361" checksum="A677C520C5C647B3" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3I2</accession>
    <name>A0A0D2X3I2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage erythroblast attacher protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_005009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3I2"/>
    <dbReference type="FunCoup" id="A0A0D2X3I2">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X3I2"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3I2"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3I2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="177"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CRA" evidence="3">
        <location>
            <begin position="230"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE94354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="414" mass="46554" checksum="4DCAAEB65E0F883E" modified="2015-04-29" version="1">MDEQTGSSSSSSSSSAGSALGVLEHPFLKVPYESLNRSFRNSQKLLEKEMAHVVATYADLQKRADAANPASRLSGSAAVQGIENVVARLHKLKRKAMQVEEVLGKEDQDIQRCKIRLDHLQQQQSAKTIGAPDQQLIWNMTRLDRVIVDHLLREGYVETANKFATDNGILDLVDVDVFLESRSIEEALQRHDCTAALAWCNVNKSRLKKSESDFEFHLRRQEFVELLRSGKRAEAIAHARKHMSPFSDTNMRDIQTAMGCLAFQPSTDCDSYKRLFDSSCWNDLVEEFRHDSFMIHSLTSQSLLSISLQAGLSALKTPMCYQHEDKNPNCPVCSTTINDLARDLPFSHRTQSCIVCRISGEVMNEHNLPMALPNGNVYSFTALQEMARANNGIITDPRTKQTYSVSELRKVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3V5</accession>
    <name>A0A0D2X3V5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MEIOB family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3V5"/>
    <dbReference type="STRING" id="595528.A0A0D2X3V5"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X3V5"/>
    <dbReference type="OrthoDB" id="9937820at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3V5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056880">
        <property type="entry name" value="OB_MEIOB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24903">
        <property type="entry name" value="OB_MEIOB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIOB-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="4">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="465" mass="52046" checksum="CB66D93ED8CAD05B" modified="2015-04-29" version="1">MSRATIDQLSAGMQSLTVVGLVVAKLSIGTFEDRKNPGTSRSRFTFTLRDSESDSINCTMWGDPNLIGSAHSRFNTGDVVEVIHPQVVPKNPTQEQRWMPRTSSAYALQLNSSSDVQLYMGDLPDRQRFVRIPMLYESGFVKIQDILASPQELSQQYINVLGIVSRIGAVTSTTTSNGRATDKLEVYLTDDSGGEIRMTLWGSCIAMASNWTVRDTILFLSDVRVRTSSFVPSAARNDPTQEHERMVYTTELSFDNCSLVTEYPDLREAQELYDYAQQLPADAFTTASRMGGGMSRAAFKPIRNDEIVESQVVNVDVAGVYALRPPVFVFDVFITDLPLDDFYTQVVIARCPGCNQQLPVEHACNRPECANLGENAADNPANWQIQLPIAVTDATGTLLKIVLQGDPAMSLIGVDASELYFMSYEERSALRRRHIFQRHRVVCKMSQYRSFAQYPLYEVVRMDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X3V7</accession>
    <name>A0A0D2X3V7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_005515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE94979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346188.1">
        <property type="nucleotide sequence ID" value="XM_004346138.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X3V7"/>
    <dbReference type="STRING" id="595528.A0A0D2X3V7"/>
    <dbReference type="InParanoid" id="A0A0D2X3V7"/>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X3V7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254864" description="Laminin G domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE94979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="400" mass="42746" checksum="ED9A55313B7992DD" modified="2015-04-29" version="1">MKTITVLFVGAFIFALASATPVCPPERTSPYFFGASGFIAKQGALAVEPNGDTSLRSIEFKLRLRDTPAVLTEQILAYGHHTYYFDEFAIFLQWDGANLALGGWFNAGYVGIVTFAGTGNPLLDHALHTFKATFDVAGVVTLFLDDVIIQSGSILSPPSTLSTININGPLLIGGTATYNAFDGCISDVRVNGVDQVLNTGYITPVALEGCVFPEVRGFDGAGYVKYYPQTGAEHDAGVTDIRIEFHPNPAYADGLILYESGLQYAFALELVGGHLRLFIKGGGASNLVLVSANIFQTDRWFTVEITRDGQQVRMRISNPSLGFLEDLVGTVQTGPLTYTVDSRLYVGGHSDPLGGLVGVTAANSFRGCLRNLIANGGPLDFSDSIEEVGVNTSPTCSFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X470</accession>
    <name>A0A0D2X470_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X470"/>
    <dbReference type="InParanoid" id="A0A0D2X470"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="578" mass="63887" checksum="C2B659E2C7E7F111" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X4Z6</accession>
    <name>A0A0D2X4Z6_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NY-REN-60 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_007171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346372">
        <property type="protein sequence ID" value="KJE96924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343895.1">
        <property type="nucleotide sequence ID" value="XM_004343845.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2X4Z6"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X4Z6"/>
    <dbReference type="OMA" id="HASEINH"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X4Z6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="680"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1587"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1967"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1995"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE96924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="2127" mass="226331" checksum="C48510ED00220B31" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5K9</accession>
    <name>A0A0D2X5K9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_008048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346376">
        <property type="protein sequence ID" value="KJE97989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342649.2">
        <property type="nucleotide sequence ID" value="XM_004342600.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5K9"/>
    <dbReference type="STRING" id="595528.A0A0D2X5K9"/>
    <dbReference type="eggNOG" id="ENOG502QS64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2X5K9"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2X5K9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="6">
        <location>
            <begin position="63"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE97989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="278" mass="29006" checksum="09323BBADD286CEA" modified="2015-04-29" version="1">MAKEIKKSNIYTKTGDQGTSSLYTGERRTKAHAIFNALGDVDELNSALGLARAYCVVPSTGSTGTTDSAAATCTTAVTGSGAESRKGQLVPLIEDIQCALLEIGSSIGTPRTWKAPQDESDTTPADQGVAAAGDDEEDPEEAAKRARMLASTAFDAEGVRLAALEHAIDLYDSLLPRLTNFILPSGGLASSHLHLARSICRRAERAVVPLLQSGAGEKSVGKYLNRLSDFLFVAARFAAQQDGQTEVVFRAAAAAATAAATTATAAAGKREPHERSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2X5T5</accession>
    <name>A0A0D2X5T5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346402">
        <property type="protein sequence ID" value="KJE98369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2X5T5"/>
    <dbReference type="InParanoid" id="A0A0D2X5T5"/>
    <dbReference type="OrthoDB" id="2429079at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE98369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="186" mass="20452" checksum="946CF2AA4A2399AA" modified="2015-04-29" version="1">MHAMQYPPNLVQLQVAAAGSSSSSSSSSPALTTANPPRVMFVLILDEFQRALIHEGVAPEPWDPVANKIASPFLQSIVEAMATCSIRSISQQTWHCTALFAGLTFVPLEELIRGSSHSLTRFPVPCLTFGQSVAYVKYYMETQRPTSWPQDFDITQDAVFQRVLMYASGHARSLEAICATLSQMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U010</accession>
    <name>A0A0D2U010_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome 26S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_000159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365030.1">
        <property type="nucleotide sequence ID" value="XM_004364973.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U010"/>
    <dbReference type="FunCoup" id="A0A0D2U010">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2U010"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U010"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U010"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="6">
        <location>
            <begin position="820"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE88511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="890" mass="96343" checksum="F3625AEA2DDA716F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1R8</accession>
    <name>A0A0D2U1R8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_000652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1R8"/>
    <dbReference type="STRING" id="595528.A0A0D2U1R8"/>
    <dbReference type="eggNOG" id="KOG2211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U1R8"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U1R8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265349" description="Conserved oligomeric Golgi complex subunit 5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="927" mass="99753" checksum="6C3F8F6D17A23BE5" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3I7</accession>
    <name>A0A0D2U3I7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_001211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE89786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3I7"/>
    <dbReference type="STRING" id="595528.A0A0D2U3I7"/>
    <dbReference type="eggNOG" id="KOG0532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U3I7"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21205">
        <property type="entry name" value="CH_LRCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="816"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE89786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="978" mass="105198" checksum="09B57C7B354943FC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5H0</accession>
    <name>A0A0D2U5H0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_001710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364578.1">
        <property type="nucleotide sequence ID" value="XM_004364521.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5H0"/>
    <dbReference type="eggNOG" id="ENOG502SE2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U5H0"/>
    <dbReference type="OrthoDB" id="360585at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="436"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="556" mass="57995" checksum="E9CB7E2AE907F968" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U690</accession>
    <name>A0A0D2U690_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_001923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364791.1">
        <property type="nucleotide sequence ID" value="XM_004364734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U690"/>
    <dbReference type="InParanoid" id="A0A0D2U690"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="141" mass="15565" checksum="A34A62FC412D3EF6" modified="2015-04-29" version="1">MPPTPPHAANVAATSSAVQLRIRCCPVIPEPLEEAAACLVTAQLLHDPRLAGLSITTTAQTFDMATLEEIKALFEEQKTNLTQQIESLRTDVSKKLDDVDAKTSFMVEARMRASLAKRFGEDYACQQFVEPRCGTITARWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7S9</accession>
    <name>A0A0D2U7S9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_002316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349066.1">
        <property type="nucleotide sequence ID" value="XM_004349016.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7S9"/>
    <dbReference type="STRING" id="595528.A0A0D2U7S9"/>
    <dbReference type="eggNOG" id="ENOG502QSEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U7S9"/>
    <dbReference type="OMA" id="CATRSSI"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U7S9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="53635" checksum="A4C1CC23F20D4B52" modified="2015-04-29" version="1">MTNPAQQHPGATANALSPVHIVSKAVVTCSNPAVSLPALGESPVFKLGPLDQLALPFIPVAVVLVYRPTSPAAAPGLLEVDRLQFALSRLLDYYPHLTGRLQMNKADNTVEVVQLGAGMEFRVATCDARLPDTCGGVTQPLVVTELPDGGNALLGAFNPWDDDGCGDHIFTLQHTRFACGSVALGVRVRHCVTDADGCFQLLRDLAELAFGRRAASGARLPTAYHLLAPAATAATAATSGGTEAETSTPAVPPPPVVGRILRFSGRELERLKAHATLTAAEFGQQWLSTFDVLAAHLYQRTHVARVQYAKSRGADPSQLSTDFLSPFNLRGRLGLPARYFPNAVSCAVFTYPADSFATAPLSAVAATIHDAMRQMTKQEAVDTLRWMSVQSDKRRIAQHFRPLNGGFMVSQWNKFDMYPQLDFDVGADSAPIPPTLVSTPFSPISLIDGLAYFLATEDQLSVSASTTTTQSVDVAIALIEPLWELLDCDPAFRQFRDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8H8</accession>
    <name>A0A0D2U8H8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypoxia-inducible factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349282.2">
        <property type="nucleotide sequence ID" value="XM_004349232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8H8"/>
    <dbReference type="STRING" id="595528.A0A0D2U8H8"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8H8"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8H8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036140">
        <property type="term" value="F:[protein]-asparagine 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071532">
        <property type="term" value="F:ankyrin repeat binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036139">
        <property type="term" value="F:peptidyl-histidine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1010">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027452">
        <property type="entry name" value="FIH-1_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="222"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="408" mass="45486" checksum="E8F43940623C8A0C" modified="2015-04-29" version="1">MDQVASHISQQIERGRLRLPGVSSPVVNCRQLGVATQPIPRYRATDDAARLALRSKTPFVLLDSSIAAPAVERWDLEFLKEHLGMSNTVFVSSTGKVKYFDETRLTPGQEASHHDVRKLTMRFAEFLECMAVAARQTERFAPRPQSSCNEPTTSTQRDSCCQPTAAAAVAPADAAAFDSNSQQPPAASDDSAARIASQFGIHSGDVVYLQQGLSNSVGLKIVESFLQFNWKLLAELQRDANWSDLTTNLLLVSMAGAVTPAHYDEQENLFAQVRGAKRCVLFAPDRFPCLYPYPVHHPCDRQSQVDFDNPDLARFPRFSELHGWECILEPGEVLYIPAYWWHHVESLTDSVSVNFWYLVGPPEIAHPLTYQQKISVMRNIEKMLGEALGDPTQLSSLLSDLVLGRYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8W6</accession>
    <name>A0A0D2U8W6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAOG_002639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8W6"/>
    <dbReference type="STRING" id="595528.A0A0D2U8W6"/>
    <dbReference type="eggNOG" id="KOG2736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2U8W6"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2U8W6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJE91511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="620" mass="65972" checksum="A479F3AF46072C32" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA48</accession>
    <name>A0A0D2UA48_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA48"/>
    <dbReference type="InParanoid" id="A0A0D2UA48"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="54" mass="5648" checksum="29A693477FC90338" modified="2015-04-29" version="1">MAYLRSEGLMTAETVAADFDKLKSFRLRPDSAPAATPVTTAPVVVATPPAAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB82</accession>
    <name>A0A0D2UB82_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB82"/>
    <dbReference type="InParanoid" id="A0A0D2UB82"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="221" mass="23955" checksum="57AB8FBE0C3497E4" modified="2015-04-29" version="1">MADHEQADDTTASTASTSSATSVPAEPMSTQEMMRMMAQVFREQMVSMAQEVVKDAMRKETLRAEGTMAAAGASSSTSAPGELVTEQSVMLLFAQFQEAVFKRMDEHGKRGAHDETPELAETSHAVSTTAVATTSSPDVTITSTTPASAAICTNLRRHGSKVERFSGSREDAKDIRRKTISDHNRDSLASTDSSAMLSYESMTEKQRELYDKAKNASETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCA9</accession>
    <name>A0A0D2UCA9_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348453.1">
        <property type="nucleotide sequence ID" value="XM_004348403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCA9"/>
    <dbReference type="InParanoid" id="A0A0D2UCA9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="324" mass="35735" checksum="E11D5CD4DE716C1A" modified="2015-04-29" version="1">MSSSQAALVPASTEQAKLEQAIAELTQALAADRAERQGLRQLADAARATGLLQDAQQYETRADTILAIINTTSERLNRLEARLNPAPAAALQVSSEAPFVCGKLAGTHESYKIIHSLDVKTIFTELCSMNAGRCEGARIQKVLHQRIVSVPGSQNISEEVVLDLNPGDPVKNEAEIVLVPHFHQYVFVFRTLAQDQSLRVLAKSLAKNMHDTSEQSIPISGHVRRISSIDLEVTIRAPFKRLIDDVLHRFRNAPEHVPQGRNVSIQVDEPRYTKGIGVLHSHFEVLKYGGDLRRADGMPSDDEPTSDVWSLASDDVAAMYPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCT8</accession>
    <name>A0A0D2UCT8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCT8"/>
    <dbReference type="STRING" id="595528.A0A0D2UCT8"/>
    <dbReference type="eggNOG" id="KOG2528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UCT8"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UCT8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="273"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="72406" checksum="715E028F6B55029B" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHW3</accession>
    <name>A0A0D2UHW3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHW3"/>
    <dbReference type="InParanoid" id="A0A0D2UHW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252823" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7951" checksum="EB3FE0421272D7AF" modified="2015-04-29" version="1">MPAPRHCLLPACPANALALLTIRLPLTTYHGVLNCDRLLWVARSRFCVVFTVGFDDATCNDAVLGAVTVARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UIX1</accession>
    <name>A0A0D2UIX1_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM and SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_005568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346241.2">
        <property type="nucleotide sequence ID" value="XM_004346191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UIX1"/>
    <dbReference type="STRING" id="595528.A0A0D2UIX1"/>
    <dbReference type="eggNOG" id="KOG1702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UIX1"/>
    <dbReference type="OrthoDB" id="191061at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UIX1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE95076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="220" mass="24019" checksum="3A64420BABD42660" modified="2015-04-29" version="1">MNPPCARCTKPVYPVEKLNALDQAWHKMCFNCEVCKITLNMKTYRGLNKKPYCQTHYPKGTFTAVADTPEAKRIAENTKQSSMAAYHAEAEKLRGTVTSVADDPTTQRAVAATKARMNYDQRARDDETGSAPAPAQSYSAPAQSYSAPAQASYGGDEEEEAPPAPRAPAARAAPAPAPVAEAPAWKAIYSYEASDADEVSFEEGDEARGGRRSYRRHCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNH5</accession>
    <name>A0A0D2UNH5_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_006848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346371">
        <property type="protein sequence ID" value="KJE96541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004344469.1">
        <property type="nucleotide sequence ID" value="XM_004344419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNH5"/>
    <dbReference type="STRING" id="595528.A0A0D2UNH5"/>
    <dbReference type="MEROPS" id="T03.025"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UNH5"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UNH5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE96541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="563" mass="59150" checksum="7849CB41BC43B32F" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQK3</accession>
    <name>A0A0D2UQK3_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Substrate carrier family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346373">
        <property type="protein sequence ID" value="KJE97291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343599.2">
        <property type="nucleotide sequence ID" value="XM_004343549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQK3"/>
    <dbReference type="FunCoup" id="A0A0D2UQK3">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2UQK3"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UQK3"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UQK3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="259"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="356"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="452" mass="47789" checksum="EAA35854F7836C6A" modified="2015-04-29" version="1">MQQQPQPHTLHSRLGGHAADRHNPVARWWAGRRSSPRFSVACGHQQQQHETRPSASISPSSPSSPSLSSLSSLASPSVVVGLKTRPMIAAFAVAESVDPHRWLGNGNGSDGGNGSDSTEVPIAGPGNAVVAPPRARASATATSSVTGATAGAAGRSDAGASSASPARTAAHILSGAGSGAVAALVTTPLDVIKTRMQVSSQTRGLRATFLQIVRTEGALKLYSGLSPTLMGLLPNWAIYFTTYETLKHPVANMLGTSVLSPMVHASSAMLAGASCALATNPLWVVKTRMMTQNSASHHQYNGLLHAFQTIARTEGVRGFYKGLVPSLLGVVHVGIQFPLYERLKGYFLAQNPDHPLGPVQLMTSAALSKIVASVIWYPHEVVRARLQNQSQSPPKYHGVIHTVRLTVQESGVRALYAGLFTNLLRVVPAGAITFTTYEMFNRMLLQVLEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR98</accession>
    <name>A0A0D2UR98_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abca3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_007365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343224.1">
        <property type="nucleotide sequence ID" value="XM_004343174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR98"/>
    <dbReference type="STRING" id="595528.A0A0D2UR98"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2UR98"/>
    <dbReference type="OMA" id="HSMKECE"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2UR98"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABCA1-4-like C-terminal R2 regulatory" evidence="1">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE97521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="209" mass="23534" checksum="795D95680CA84651" modified="2015-04-29" version="1">MRNGRSIILTSHSMEECEALCTRLAIMVNGEFKCIDSPQHLKNRFGSGYTMTVKLQRDLSAGAREPDTFPVKQFVHETFPGAVLKEEHQGALHYEIATPEQSGSSAVKSLSWAFIFSKMEEAKRMDPIEDYGVSQTSLEQVFIEFAKRQQGVYLTQVKQLSVASSIGPTYYSRWYRCWLVADGILTPQLADAIFMAFVRAFAVLSESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URN2</accession>
    <name>A0A0D2URN2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_007430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346374">
        <property type="protein sequence ID" value="KJE97601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004343289.1">
        <property type="nucleotide sequence ID" value="XM_004343239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URN2"/>
    <dbReference type="STRING" id="595528.A0A0D2URN2"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URN2"/>
    <dbReference type="OMA" id="MSDAKMN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URN2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE97601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="316" mass="33099" checksum="D255B11ADD9C122B" modified="2015-04-29" version="1">MPPPVKSSTAAAASTSSSSSTNTRPSSKRTHAESAASDALEADPETTAAATKTQPRVVTSQSGFRKTVREGDAAAAAADQADRASSKSSSKDKKSSSKDKDKAKDKDKAKDKGKDGSTRRRPKPAGASAAAGSSTTAAAGGGASKDKDNNGDAEESRKKPRLDKDDDQEEGETDAKAKSPAAAKARYIVFIGNLPYTATADDVRSFLSPCGETDAVRMLTNKATGESRGCAFVEYSNQKSLQKALRYHGMAFGDREVRVELTAGGGGKGKARLDKIAAKKDSMAETRRKQRVASLKKMEKRQNAAQKNAASGEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URV8</accession>
    <name>A0A0D2URV8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Folate carrier protein Flx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_007801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URV8"/>
    <dbReference type="FunCoup" id="A0A0D2URV8">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2URV8"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2URV8"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2URV8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="312" mass="33790" checksum="F10B493FD6712185" modified="2015-04-29" version="1">MGASSSHGEGSGSDRSDAATRNPANDTAMTTTSSSHSSTDPATAGAAAGAGAKAARKPPTCIHLLGGAAAGLVTTTLLHPLDLIKIRMQVHDGTKERGERYRSSWHAFKSIKYREGPMALYRGLTPNLVGSTTAWGLYFFIYNIAKSQWQSFLNMKELGPAENMAAAVTAGVGTQILTNPIWVVKTRMCSSPISAGGPLQYRSLSHALGLIWRQEGLAGFYRGILPGLLSVSHGSLQFMAYEEMKKWVTRREAYASHRHEMGTLEYTVMAAASKMFATIAAYPFQLARTRLQVRSVGCGFDFCLFCFCLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US50</accession>
    <name>A0A0D2US50_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAOG_007889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 30864</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE346375">
        <property type="protein sequence ID" value="KJE97791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342974.1">
        <property type="nucleotide sequence ID" value="XM_004342924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US50"/>
    <dbReference type="STRING" id="595528.A0A0D2US50"/>
    <dbReference type="eggNOG" id="KOG0792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2US50"/>
    <dbReference type="OrthoDB" id="165498at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="453"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="633"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJE97791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="730" mass="82071" checksum="38C1BBE921E18836" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGJ8</accession>
    <name>A0A0D2VGJ8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_000564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365435.2">
        <property type="nucleotide sequence ID" value="XM_004365378.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGJ8"/>
    <dbReference type="eggNOG" id="KOG3569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGJ8"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="69"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1614" mass="176823" checksum="7F5013EE53BBD84E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGL0</accession>
    <name>A0A0D2VGL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAOG_000572</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365443.2">
        <property type="nucleotide sequence ID" value="XM_004365386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGL0"/>
    <dbReference type="FunCoup" id="A0A0D2VGL0">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VGL0"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VGL0"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VGL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000035">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1014"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="840"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJE89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130959" checksum="61670F68341A15BC" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJI3</accession>
    <name>A0A0D2VJI3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_001458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364326.2">
        <property type="nucleotide sequence ID" value="XM_004364269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJI3"/>
    <dbReference type="FunCoup" id="A0A0D2VJI3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VJI3"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VJI3"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VJI3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE90107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="268" mass="29919" checksum="11E29B09FCA94F6C" modified="2015-04-29" version="1">MAPAAIPLLLDTSIRDWVLIPIVIVMFLLGIVRHHITELLKSDRIDDKAAKAALDGQGLLRARVLRANGRFLSPLAFQMRKNFFTQADGGDDSKKGWLMQERPKPANPMGDPSQMMGMLKNNMSFVIPQMLIMGWINYFFSGFIATRVPFPLTVRFKMMLQRGIELPTLDASWVSSLSWYFLAVFGVRGLHTLVLGEGNAADQSMNMQQMAGMGMTPNPTVDMNQVFKAERENLDLCVHEYALANIERALLDTASVSATSTTSKLKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL89</accession>
    <name>A0A0D2VL89_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348860.1">
        <property type="nucleotide sequence ID" value="XM_004348810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL89"/>
    <dbReference type="STRING" id="595528.A0A0D2VL89"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VL89"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VL89"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE90872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="149" mass="15295" checksum="79583DD982F232E2" modified="2015-04-29" version="1">MLSRLSTSIARAVASAGQVRTCITAGAAAAAAGAAPLHSSAASLHGHTHGGQPCDGDHGGMTEGEERISNILLDKLKPTALGVNDISGGCGSMYQIGVESPMFAGLSLVQQHRLVNEILKDEIKGMHGMRLQTRTTPPKPAADDKSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM19</accession>
    <name>A0A0D2VM19_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testis mitotic checkpoint BUB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_002326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349076.1">
        <property type="nucleotide sequence ID" value="XM_004349026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VM19"/>
    <dbReference type="FunCoup" id="A0A0D2VM19">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VM19"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VM19"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VM19"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE91147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="329" mass="35569" checksum="AFCE51502C59F271" modified="2015-04-29" version="1">MSSPAEFQLASPPSDGISSVTFAPAGSLNTDMLLASCWDSTLRLYNAATNTLLANFAHASAVLDSTFGPEGRVCYSGAVDGSLSSCDITTGAQSTLGGHAQGIRCVKFDPATGLVVTGSWDESVKLWDARTARCVSTHQQSAKVFAMACTSDSKLIVGTADRHILIWDLRKMESVLQRRESSLKFQTRCIQPFSNGHGYVLGSIEGRIAVEYIDPSPAVQQKKYAFKCHRVPINGVNTIYPVNSISFHPLYNTFASGGGDGIVSIWDGLNKRRICQLRPYPTSIASLAFNHDGSLLAIASSYTFEEGEKDMPNDAIFIRRITDADVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMS3</accession>
    <name>A0A0D2VMS3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_002626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 6"/>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349376.2">
        <property type="nucleotide sequence ID" value="XM_004349326.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VMS3"/>
    <dbReference type="FunCoup" id="A0A0D2VMS3">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VMS3"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VMS3"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VMS3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE91497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="788" mass="85123" checksum="3B63DDC05A0C5FB7" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNG7</accession>
    <name>A0A0D2VNG7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_002931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363770.1">
        <property type="nucleotide sequence ID" value="XM_004363713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VNG7"/>
    <dbReference type="FunCoup" id="A0A0D2VNG7">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2VNG7"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VNG7"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VNG7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="232"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="456"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE91862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="546" mass="59270" checksum="031ABC402D55006A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQM9</accession>
    <name>A0A0D2VQM9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDAN1-interacting nuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_003863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQM9"/>
    <dbReference type="STRING" id="595528.A0A0D2VQM9"/>
    <dbReference type="eggNOG" id="ENOG502R9SY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VQM9"/>
    <dbReference type="OrthoDB" id="1272at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VQM9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE92997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="303" mass="34450" checksum="525F2B5D39015082" modified="2015-04-29" version="1">MRESVYHEIVAMLEADFPPMEIVQRHSTITLNAIHSIRAQKSQEWLKKTAYQHSSPEAMLLYWRAFTAMAFPADQVNASNPSPAPSAPSPTELTPENSIAWQLCMRYNIPPCTLARVLLSLFLAQGDVRDGISKKNPRVKELMQRPELIPDLVLRREVQCCIQYDDMTSPLVERVKHCVGAEYEALLQEKLRNLGIPFLNEEDMRKADAHKTPDIKLQAPIVVNGSVVLWIESKAYFGDRPNHTRNQAQLFGYLSRYGPGMVIYWFGFIDELNVDHDKGIQMLDHFPTKVSMELPPGMASDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRG9</accession>
    <name>A0A0D2VRG9_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_004250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348075.1">
        <property type="nucleotide sequence ID" value="XM_004348025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRG9"/>
    <dbReference type="eggNOG" id="ENOG502SU48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VRG9"/>
    <dbReference type="OMA" id="WILRTMN"/>
    <dbReference type="OrthoDB" id="5583977at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VRG9"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE93462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41191" checksum="470A895A1198707B" modified="2015-04-29" version="1">MPDKTVDFNLDESPFAAEWGLYGVALVNFLVNFTVACYLVYWRNWAPIRAKQLDFLLLSSASGWIWLIGAMSATRTIPQVGAMLSCNFWAFWVQFCFGALMWCACIILRMYRLYVIMIATKMRMNVSNPRAWMYGRLVMVCSPVILFCIIATATNAVPIVPQPTSAGVYVDLCSMEWWALYSLMVFCIVYLLLVVWLMVQLRRIRKFLNEFRETKIAFWCVVISGVFYAVIHVMAWQKKVWGRVLCVAMILVMVNVSYWLILGPTVIGRWFNPEAFLAKFHADKDYQPNSTTKKENSSTKHNMSINPLAKASSRKSEGQSDRTEESEHNQSEFEVRMTENEFSVVPAGEIAGNEDGPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTM8</accession>
    <name>A0A0D2VTM8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346922.1">
        <property type="nucleotide sequence ID" value="XM_004346872.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTM8"/>
    <dbReference type="InParanoid" id="A0A0D2VTM8"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTM8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="354" mass="38927" checksum="B4368BADD0E08D8D" modified="2015-04-29" version="1">MATTSATLMVLDHRQGAVNGIAQSNHQLVDVQVTQSPVDLPATRQSKWVKSARFNAAQCAQGIKKVYECNLTPKERVLIQDEAVFLFFNGGKNTATGKNKRAVHCNNKKKCARWRDGYKYRKAHNTSTDGGMVYPPIDPNGLFKTLYQIDDDKVLVRYTKETPTVLAAKPATRTSPKACPSDRNSRASPVRPPTPVTESESEIEDSEDDDSIGGSDVPMCDSPASIVGSEVADMAVLAADDRRVRSPCHEMQSLPTATLTVPGLSGEPKEWDVATLRLAADAELHVRDFSHSDPSQFQNDVELDRPFLNHASTVGSEVSDETLNDPHFDLVRLVAPDLTDDNNIASCLYEFYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTX4</accession>
    <name>A0A0D2VTX4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_005364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347049.1">
        <property type="nucleotide sequence ID" value="XM_004346999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTX4"/>
    <dbReference type="STRING" id="595528.A0A0D2VTX4"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2VTX4"/>
    <dbReference type="OMA" id="HINMVAN"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2VTX4"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE94782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="268" mass="30613" checksum="F1EEA83BB7A01BE1" modified="2015-04-29" version="1">MPEWQKTAEWPLASFSTMVALMGGYVVVIKGLQAFMKNREALRCTMAGHVHNVIMTALSAYVFFGMGYDVIQNWKENNFDPSLAVCDPELKLSKNADYWFWIFYVSKFYEYIDTILLVLRKKPVIFLHAYHHFITASIVWAAWIFPGASNWVGPITNAFVHIWMYAYYMAADFGLSRKWGAYITKIQLTQFMGCIALWACVGLAMIPDNSCKTPAESFSWLCLQYVIFLYLFRRFDSKRNGKKPAAATATKSVAASAAGNEVEDKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VW87</accession>
    <name>A0A0D2VW87_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VW87"/>
    <dbReference type="InParanoid" id="A0A0D2VW87"/>
    <dbReference type="PhylomeDB" id="A0A0D2VW87"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="555" mass="62003" checksum="37C348AEEA8B263E" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1N6</accession>
    <name>A0A0D2W1N6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_008235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346377">
        <property type="protein sequence ID" value="KJE98242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004342490.1">
        <property type="nucleotide sequence ID" value="XM_004342441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1N6"/>
    <dbReference type="STRING" id="595528.A0A0D2W1N6"/>
    <dbReference type="InParanoid" id="A0A0D2W1N6"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2W1N6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE98242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29884" checksum="DA064969F9085A51" modified="2015-04-29" version="1">MQQQQPMQSAAVPLRPFPPAPPTAADAPSILDGALLARAEEMRATLNEFRLFDPRIQWQDVVSKFSVLLGQTHNFVNQLSRLPAPYELALVPGQFSSKRDPEVEVATQGRISAVKPDVIPDVLLRSRPPPELEVYAAPFKSAAAALREDVRQHLVTDDAQAMDMDAIDQPSMQQQEDEMITGAVDSHNSFVDECLAAVERARALNDQEAAESEPLGNRRAQASAANTDAGIIRAAIEAHAPFTKALVSAVVYGTRLRGQPVQPAGQPVVQQPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGV4</accession>
    <name>A0A0D2WGV4_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CCR4-NOT transcription complex subunit 4</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">CCR4-associated factor 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">E3 ubiquitin-protein ligase CNOT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Potential transcriptional repressor NOT4Hp</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase CNOT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">CAOG_000302</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Interacts (via RING domain) with UBE2D2. Interacts with ABCE1, PINK1 and PELO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365173.2">
        <property type="nucleotide sequence ID" value="XM_004365116.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WGV4"/>
    <dbReference type="eggNOG" id="KOG2068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGV4"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000044">
        <property type="entry name" value="Putative ccr4-not transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 25" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 26" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 26" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="29">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="30">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="26">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="246"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="666"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="983"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1185"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1237"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1309"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="431"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="759"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1244"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1309"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1323"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KJE88705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1373" mass="141175" checksum="6BB58FC678B0CDE2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WGW3</accession>
    <name>A0A0D2WGW3_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_000320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WGW3"/>
    <dbReference type="STRING" id="595528.A0A0D2WGW3"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WGW3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WGW3"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000069">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF272">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="393" mass="41198" checksum="A19CD51C8A92AC82" modified="2015-04-29" version="1">MAVKHYFCHNCNLQFSVVDPPVASDDGIVCDHCHTGFVEEIEDGGAAAAGHDGTAQSVDDNDNDDDDEYEDDDDEQDDNPLASFLRGASSHALRGIHDQYGDGDDDDDDDDDDDDEGEGDDAAAEDEVEFRGTRSVGRRLSRNRNTVTSTTRVSHAPSTNTRAAGSRGGSTGAAASSTETASTRPQQPSSHRAASSEQQRHRGVNVQNRDEILFQVVNPMVGNPGDYVHDDAGLDNVITRLMEQSGGKQGAPPASSAALSSLPTVLMTAELLASSGDCAVCKDSFSLDEGVLQLPCHHLFHNNCILPWLKQNGTCPVCRKAVDGANTVASNSSTQPSSAAPARSSTPLASNSASSVSAPSATGRAAPAASYAFASVDADPDDGDALYQFHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WH34</accession>
    <name>A0A0D2WH34_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WH34"/>
    <dbReference type="InParanoid" id="A0A0D2WH34"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="386" mass="41899" checksum="37012B81F3E630BE" modified="2015-04-29" version="1">MSEIDDSNWIASSQNEQVQKTFNALHPWIKQLASNALSGLNTQSLFLLFFFFPKSSKQKMPAPAFARVVPRIPTQNSFEALEGLEGLDDSETAAFVQPKPASASRQESRRQQLRQQSAVAELATEAEQATASSHVAIAMNDADNSDSADDDEDTSSSCQPVDLEQGHAQHPSRASSSSQLDAAAPAAESRSRAKPRRNNRQPTTADSSSAAAPSSSSSSSSSSSSSSSSSPFVTAMREQTRDMRQIVGSLYALLFTRVPILNRLSPRIVKILLACLILDVIVPDDYDFESEDWGCFAGVTEDNPFCPTVELLDDMDDFVGSVAAAMDGAMESFVSHLTDEMDWLELISAFKQHFLPNVHPMTMHGLRGSLSFALSYVRLIVAHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WI10</accession>
    <name>A0A0D2WI10_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ependymin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_000873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365744.1">
        <property type="nucleotide sequence ID" value="XM_004365687.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WI10"/>
    <dbReference type="eggNOG" id="ENOG502S2YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WI10"/>
    <dbReference type="OMA" id="TMKDCYP"/>
    <dbReference type="OrthoDB" id="6084362at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WI10"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00317">
        <property type="entry name" value="EPENDYMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00026">
        <property type="entry name" value="EPEND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254466" evidence="1">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="195" mass="21581" checksum="995AE8C5D138EC9D" modified="2015-04-29" version="1">MFKVTLAVLALACLALAQEHQRCIAPSQFESRIVEVDPSKQFELRGKLVYDAHNQRTATIEEVVVGSQKPAFYHTITLHQLGAQYNINLQTKECKIQTIPRQWRPFEIPHNSTFYGGVIVGTEAFADSGVEVDLWGGHTESGDSWTGAFTSRICIPVSDSVRGDKIGFVHTSFFDTVLGISDPNVFIPPSNCVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJ80</accession>
    <name>A0A0D2WJ80_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myosin IIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAOG_000840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365711.1">
        <property type="nucleotide sequence ID" value="XM_004365654.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJ80"/>
    <dbReference type="eggNOG" id="KOG3601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJ80"/>
    <dbReference type="OMA" id="AMIFRES"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJ80"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF5">
        <property type="entry name" value="MYOSIN-IIIB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="26"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="631"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1375"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1462"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="840"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1378"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1462"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJE89348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1503" mass="166697" checksum="20D57E7B8E81DAA2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJQ0</accession>
    <name>A0A0D2WJQ0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_001036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004365907.1">
        <property type="nucleotide sequence ID" value="XM_004365850.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJQ0"/>
    <dbReference type="STRING" id="595528.A0A0D2WJQ0"/>
    <dbReference type="InParanoid" id="A0A0D2WJQ0"/>
    <dbReference type="OMA" id="HSERMVE"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE89598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1083" mass="113429" checksum="63FCD54651A6A5F2" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WJT2</accession>
    <name>A0A0D2WJT2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_008477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346360">
        <property type="protein sequence ID" value="KJE89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_011270049.1">
        <property type="nucleotide sequence ID" value="XM_011271747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WJT2"/>
    <dbReference type="FunCoup" id="A0A0D2WJT2">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WJT2"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WJT2"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WJT2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="126"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34489" checksum="4B4282986CB4DF9E" modified="2015-04-29" version="1">MDRSTLNLLAPRQFYVVPAPVDSGRKKTPGKAILAGGISGGIEILITFPTEFVKTQLQLDERAAQPKYKGPIHVVTSTIKERGFFGLYRGLSSLLYGSIPKSAIRFASFEFFKNQIADKDGKLTTLQTLGCGLGAGVTEAIFAVCPMETIKVKFIHDQNQPQPKYRGFAHGVSTIVKTEGFAGIYQGLGPTILKQGSNQAIRFVVYGKITNWMKGGDDSKKLGVLQTLSSGALAGAASVFGNTPIDVVKTRMQGLDRHKYKNAWDCTKQIWKNEGFFAFYKGTTPRLGRVCLDVAIVFTLYERIYDALIAVEGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKL0</accession>
    <name>A0A0D2WKL0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAOG_001487</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364355.2">
        <property type="nucleotide sequence ID" value="XM_004364298.2"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WKL0"/>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WKL0"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WKL0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254438" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="16">
        <location>
            <begin position="31"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1296"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1330"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1370"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1423"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1455"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1486"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="17">
        <location>
            <begin position="1261"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJE90138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="1613" mass="167749" checksum="A68A2DCD3C57174C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WKQ7</accession>
    <name>A0A0D2WKQ7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_001582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346361">
        <property type="protein sequence ID" value="KJE90243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364450.1">
        <property type="nucleotide sequence ID" value="XM_004364393.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WKQ7"/>
    <dbReference type="InParanoid" id="A0A0D2WKQ7"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE90243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="258" mass="26154" checksum="3DD8AB07BF642CBE" modified="2015-04-29" version="1">MNSTGWPPAGELSQPNAAPATSIMGVAASAPTYAHQQQQQQQQQQHHHTQQQLVQLGLGLGLDFSSLSEVAALASRLSGQHPAASHGDLGTAGLRTLYNPVLSVESTGGSAGGVGVGLFGGSDDHLGANPAETGSGDDDESNKNKLRERNKTAAAKSRLKKKQREHQLQQRARHMVERNGDLKTAMAKMETEVQALREKMAAATAAAATGTATAATATAATGTGTGTGAPSSSSSALSSSAASPSSQAGLAAVNQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WLJ7</accession>
    <name>A0A0D2WLJ7_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_002013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE90758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004348763.2">
        <property type="nucleotide sequence ID" value="XM_004348713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WLJ7"/>
    <dbReference type="FunCoup" id="A0A0D2WLJ7">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WLJ7"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WLJ7"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WLJ7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE90758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="161" mass="17644" checksum="236E0747C868A082" modified="2015-04-29" version="1">MSMTVQKRLMRELAEVERNAAAEFDLGSSEDNLLVWTAVLRPPAPSLYQGGVFHVSIRVPNTYPMTPPAVKFSTRICHPNIHWKSGDVCLDILKTAWSPAWTLRTLCLALLVLLDNPEVDSPLNCDAGNLLRCGDKRGYKSLVTMLTALHATPASASSSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMA8</accession>
    <name>A0A0D2WMA8_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMA8"/>
    <dbReference type="STRING" id="595528.A0A0D2WMA8"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMA8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMA8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197:SF44">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="371" mass="39612" checksum="696800C55810E22D" modified="2015-04-29" version="1">MSSDASIHQALMRALDRDTDSFTELLTELTERVGRDRVTAILNSVSPRGQHSGLSNCQKRTSLSVFEMLVKEFKVPTSTADGTKSTPLIAAICSSAEDIVQFLLSAPGKLNLDAADNQGCTALHWALRLSQSDVAKSLIERGARVDLATTTGMQPLHDAAAENLVELLPVLVQRGANVSAIDKKGNTPLHFAMSKGHLDAVEVLTEKLASPVDGHNIAAANGNLKQVQMFVARSKNVNQLDQNGASAVANAKENGHSAVVEYLLANGGLEIDAAPAQPSAGEEQNDSDDHDDDQSDKPRKQLSSSERANMRRRARQHKAPAAAAAHASRDESHTSAPVHGTQSHEAGTPTWIIAVAVLVVILFVLAFVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMP6</accession>
    <name>A0A0D2WMP6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio domain-containing protein NOP9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAOG_003179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364018.1">
        <property type="nucleotide sequence ID" value="XM_004363961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMP6"/>
    <dbReference type="FunCoup" id="A0A0D2WMP6">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMP6"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMP6"/>
    <dbReference type="OMA" id="HHLVRNF"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMP6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJE92160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="99779" checksum="EDFE30FB0794E19A" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMT0</accession>
    <name>A0A0D2WMT0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-like protein Rab-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_002661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346362">
        <property type="protein sequence ID" value="KJE91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004349411.1">
        <property type="nucleotide sequence ID" value="XM_004349361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMT0"/>
    <dbReference type="FunCoup" id="A0A0D2WMT0">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WMT0"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WMT0"/>
    <dbReference type="OMA" id="IQQKNNC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WMT0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJE91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="205" mass="22757" checksum="A149128461B76E31" modified="2015-04-29" version="1">MTPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQDSFNNVKQWLQEIDRYASETVNKLLVGNKSDLTTKKVVDFTTAKEFADQLSIPFLETSAKNATNVEQAFMTMAAEIKNRMGPVFPAKEKGQSINIGGSTTIAKPQGGSDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WMU2</accession>
    <name>A0A0D2WMU2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_009648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WMU2"/>
    <dbReference type="InParanoid" id="A0A0D2WMU2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="190" mass="19996" checksum="395EBE8374A8FAE8" modified="2015-04-29" version="1">MMMMRMMPRVAQRRTKSESTRQSPATTPRPTALAAGADSVHPSEPQLPDSDGRLQHGWPPPRPGSMSSGPRDDSAGARDGAPALRLPAHAARPAGRHSVGRGRRIDLPSASHCVVIGPPVVVVGTVQQQQQQQQQRPAATAWAKGDSPQQSSCPSSLLLLFVLQMLLLPRGHSAAGAAAAGLRGRASVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WN66</accession>
    <name>A0A0D2WN66_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAOG_002867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE91778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WN66"/>
    <dbReference type="STRING" id="595528.A0A0D2WN66"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WN66"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WN66"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255101" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJE91778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="66113" checksum="4D78F856CF69E08D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WNP7</accession>
    <name>A0A0D2WNP7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAOG_003719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363447.2">
        <property type="nucleotide sequence ID" value="XM_004363390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WNP7"/>
    <dbReference type="FunCoup" id="A0A0D2WNP7">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WNP7"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WNP7"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WNP7"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJE92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="242" mass="25901" checksum="CDF6C19512E70842" modified="2015-04-29" version="1">MSAEVSGSHPSPLVIIVMGVSACGKSTVAQALADGWSASSASGREIRQTGAARLLDADDLHPPSNKAKMGAGIPLSDRDRAPWLAALRAKILEHVTEQRFRSQANPSSVHSSDQTSADNNANIIHDDSHNESNDSDAAKAPETLILACSALRQLYRKVLAEGPDAHTGASTAPSIAFVHLQAPFEVFDARIRDRTGHFMPASLLQSQFALLEDPTLDSPREYQVLAVDARQSLDTIQIFVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WP44</accession>
    <name>A0A0D2WP44_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAOG_003338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346363">
        <property type="protein sequence ID" value="KJE92353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004364177.1">
        <property type="nucleotide sequence ID" value="XM_004364120.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WP44"/>
    <dbReference type="STRING" id="595528.A0A0D2WP44"/>
    <dbReference type="eggNOG" id="KOG3536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WP44"/>
    <dbReference type="OrthoDB" id="9999955at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WP44"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF45">
        <property type="entry name" value="GENE 7694-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="55"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJE92353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="260" mass="28233" checksum="C25AEC94B818B8E2" modified="2015-04-29" version="1">MSLSVDEDPEKRKRTSSVGRFFENFKHRHENYGKLERTSSVEDIMKVRSPEGRVFNVVYYGTMEADESTGKAVTARALQFVEQNPSKRKMTMKVSTQGITLVDVETKITVEAHMLHHISQCAYDTSPDHYKLISYIAFNKEKSKYFCHVFKHEPTAAAIHEAISVAFEEAFKNYSANKKAATPAAPAAATAPLTTAASAASAAGSSPAASAPRSTPSLTVSNGEDGFDGLARQRTASGSGRPPVRQPSPTPVSTGNLIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPC6</accession>
    <name>A0A0D2WPC6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_004006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPC6"/>
    <dbReference type="STRING" id="595528.A0A0D2WPC6"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPC6"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPC6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="69"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE93180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="409" mass="44571" checksum="81A9696715D1BBC2" modified="2015-04-29" version="1">MQKCVRLTFAHQRLPFSDCVWPNRAKTTQHGSRMEAQFTFQKFALSNATQFKTMAETIPATMKALVKTKPTASYELVEIPVPVPGDGELLIKVERVSICGSDINLYTWNEVGQAIATLPFTPGHECVGKVVKVGPNCGEIGVGTRIGVENHYYCGNCYQCTHDLPHICKSMGQFGHGKQTVHGGCSQYTIVPARYAYVLKTNLTSQQACLLEPFGVAQHAIEEVECKDDTLLVIGCGPIGLLTVAVGRAMGAKTIIAADVIPAKLELAKTMGADHVINSKDEDMLAAVMKITNSDGAGCIVEASGSPYMVNTCFTFLRKGGRILLVGLPKQPLHVENVLHNVIFKSLTLKTIHGRKIFHTWEESERLISQGLVDISPIVSHDIPMSKFEDAFSTLLKAEGCKILMDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WPX2</accession>
    <name>A0A0D2WPX2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_003754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346364">
        <property type="protein sequence ID" value="KJE92863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004363482.1">
        <property type="nucleotide sequence ID" value="XM_004363425.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WPX2"/>
    <dbReference type="STRING" id="595528.A0A0D2WPX2"/>
    <dbReference type="eggNOG" id="KOG2796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WPX2"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WPX2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE92863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="878" mass="91988" checksum="E71FCAD728885815" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WQN6</accession>
    <name>A0A0D2WQN6_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-ATPase gamma subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_004114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346365">
        <property type="protein sequence ID" value="KJE93308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004347939.2">
        <property type="nucleotide sequence ID" value="XM_004347889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WQN6"/>
    <dbReference type="FunCoup" id="A0A0D2WQN6">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WQN6"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WQN6"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WQN6"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE93308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="306" mass="33241" checksum="5EF4EAB01B841EB5" modified="2015-04-29" version="1">MMLSRLGGVSRLAGILPSAVATAAPATAAVTPARGMATLKEIRNRLKSVRNIEKITKSMKMVSAAKFARAEKNLRTARVLGSAVQSLFEKTDLAKRPAGNNQLFVVISSDRGLCGAIHSSISKKVKQEVGQSTPDNLKFVIAGDKARTILARTHGKHILMQFAELGKRPPTFDEATLIAQQILASGYKFDSGKILYNHFRTVISYEQRALPLLSFDALAEAPEIVSYELDDDVLQNYQEFTLANTIYYAMLESSASELSARMSAMENASKNAGEMIGKLTLTFNRTRQAVITGELIEIISGASALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRF2</accession>
    <name>A0A0D2WRF2_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRF2"/>
    <dbReference type="STRING" id="595528.A0A0D2WRF2"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRF2"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRF2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE94470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="105207" checksum="0BAF3E4426A0B6D1" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WRQ5</accession>
    <name>A0A0D2WRQ5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAOG_005246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346931.1">
        <property type="nucleotide sequence ID" value="XM_004346881.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WRQ5"/>
    <dbReference type="STRING" id="595528.A0A0D2WRQ5"/>
    <dbReference type="eggNOG" id="ENOG502S7GH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WRQ5"/>
    <dbReference type="OMA" id="YKPIDSK"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WRQ5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJE94625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10313" checksum="7762495CAFE5CE4C" modified="2015-04-29" version="1">MATQTSDARKEEFRKYLETNGVIDTLTQVLVGLYEEPNKPDNAMAFLKQSLSNVRSDGGAAAEPVDVDVLLKENQALKARVAELEKELASKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSG0</accession>
    <name>A0A0D2WSG0_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_005572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346245.1">
        <property type="nucleotide sequence ID" value="XM_004346195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSG0"/>
    <dbReference type="STRING" id="595528.A0A0D2WSG0"/>
    <dbReference type="eggNOG" id="ENOG502QPWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSG0"/>
    <dbReference type="OMA" id="SYAANMW"/>
    <dbReference type="OrthoDB" id="1847654at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSG0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31354">
        <property type="entry name" value="OS01G0793500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31354:SF2">
        <property type="entry name" value="OS01G0793500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255208" evidence="1">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="582" mass="65233" checksum="195EA0AF58E9C70D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSG8</accession>
    <name>A0A0D2WSG8_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SWI/SNF and RSC complex subunit Ssr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAOG_005582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346255.2">
        <property type="nucleotide sequence ID" value="XM_004346205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSG8"/>
    <dbReference type="FunCoup" id="A0A0D2WSG8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WSG8"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSG8"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSG8"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="154"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="396"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJE95090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="627" mass="65248" checksum="250E26689868D97D" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WSR5</accession>
    <name>A0A0D2WSR5_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAOG_005170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346367">
        <property type="protein sequence ID" value="KJE94538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004346855.2">
        <property type="nucleotide sequence ID" value="XM_004346805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WSR5"/>
    <dbReference type="STRING" id="595528.A0A0D2WSR5"/>
    <dbReference type="eggNOG" id="ENOG502S4PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WSR5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WSR5"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJE94538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="428" mass="46762" checksum="23057D2512F62F42" modified="2015-04-29" version="1">MSTLSLQAPDLISSTMLLEHFTCPICCSLLSNTTITIPCGHRYCKSCIDECLNRKSVCPCCNTRLNGGVVLQRDHQYDALLEMIQKERKAADAAHLVRLVETSALCSVPTRAAPIPALLMASDEPLIVIDDPTTLASNSPVHDDADLDSSGAVTELQRVFAKHLARAVSGYVAQIQESQANKQAELSRISTDLRLRAGMDDAERLKQVAARFDKEVANTIASCDKHLERALYVPVLTKTENVAFNCYLVRGGVRICIRDLVMSPLDKVSRLIQQIQLRFEELVGDKIMSASADAGLLVCAVDSSRIVSPSTLVVKAEAGETAIPWSGAQDTLLRDYSLRPVNALLFTGALTWESECPRLCAKDSFVEGASNITNYYSCGTCKLNWICEPCREACHTGHSTVMTLRAHKPKFACCYCERGGKCCKTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTB1</accession>
    <name>A0A0D2WTB1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAOG_006059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345649.1">
        <property type="nucleotide sequence ID" value="XM_004345599.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTB1"/>
    <dbReference type="FunCoup" id="A0A0D2WTB1">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTB1"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTB1"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTB1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJE95625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="283" mass="31269" checksum="85CEA9A5426C9F73" modified="2015-04-29" version="1">MANKADNRNQDATCYVGNLDDRVNDRLLWELFLQAGPVAHVFIPKDRVSGLQQGYGFVEYPTEEDAEYATKILNMIKLFGKPIRVSRSTDRKDIDIGANLFIGNLDTEVDEKMLFDTFSAFGVILHTPKIMRDQQNGNPRGFGFVNFASFEASDAAIEAMNGQYLCNRQISVTYAFKKDMKGERHGTAAERLLAASNPFSNVSKPHQRFAEPQAQLPPPGMGGAPGMPMMIPPPFQPMGAPPAFGGYPMPPPFAMPPPFAMPPGQPPHMMMPPPFVPPPYPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTI1</accession>
    <name>A0A0D2WTI1_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAOG_006210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346369">
        <property type="protein sequence ID" value="KJE95795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004345800.1">
        <property type="nucleotide sequence ID" value="XM_004345750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTI1"/>
    <dbReference type="STRING" id="595528.A0A0D2WTI1"/>
    <dbReference type="eggNOG" id="KOG2761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTI1"/>
    <dbReference type="OMA" id="KEQCENQ"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTI1"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJE95795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="224" mass="24966" checksum="38A5D66C8A0EE607" modified="2015-04-29" version="1">MPQQRVQTIFSDIPASVLYDALHDPDYRKVWDDNMIQGFDLFHLDANNDVGYYAARLPAPLKNRDFLNQRSWFAAADGSEYIIMNHTVAHDECPPKKEFIRAVSILTGYLVRPSGESSSSSSSGCQLTYITQTDPRGSIPKALVNKGAAAFAPKIMTKLYETSKKYPAWKEKNNPDHKPWIKFDASKTRVVSVEELKKHQTDVAASLGAKDDTVVTDDTPVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTN7</accession>
    <name>A0A0D2WTN7_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAOG_006299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTN7"/>
    <dbReference type="FunCoup" id="A0A0D2WTN7">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTN7"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTN7"/>
    <dbReference type="OMA" id="LFALMMY"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTN7"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJE95905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72632" checksum="47371EE65C3B647C" modified="2015-04-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTP2</accession>
    <name>A0A0D2WTP2_CAPO3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAOG_009869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 30864</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE346368">
        <property type="protein sequence ID" value="KJE95063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTP2"/>
    <dbReference type="InParanoid" id="A0A0D2WTP2"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJE95063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008743"/>
        </source>
    </evidence>
    <sequence length="134" mass="15804" checksum="B264404A10CC1913" modified="2015-04-29" version="1">MQIWRQVLDKLTPVLIRQWKLGACQEVRVSVVAILGDKMIFFLLQTDKDINLCGVVVIILTQLASFERIHKQRRTGDVAALVFEDCVMEFLGEFRQNRLNATKWRKIKCIAHYQRRMYERKSRLPEELIPITLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WTU0</accession>
    <name>A0A0D2WTU0_CAPO3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAOG_006358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Capsaspora owczarzaki (strain ATCC 30864)</name>
        <dbReference type="NCBI Taxonomy" id="595528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Filasterea</taxon>
            <taxon>Capsaspora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Capsaspora owczarzaki ATCC 30864.</title>
            <authorList>
                <person name="Russ C."/>
                <person name="Cuomo C."/>
                <person name="Burger G."/>
                <person name="Gray M.W."/>
                <person name="Holland P.W.H."/>
                <person name="King N."/>
                <person name="Lang F.B.F."/>
                <person name="Roger A.J."/>
                <person name="Ruiz-Trillo I."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heilman E."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Mehta T."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Haas B."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 30864</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE346370">
        <property type="protein sequence ID" value="KJE95980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WTU0"/>
    <dbReference type="FunCoup" id="A0A0D2WTU0">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="595528.A0A0D2WTU0"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0D2WTU0"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="PhylomeDB" id="A0A0D2WTU0"/>
    <dbReference type="Proteomes" id="UP000008743">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="en